@article {pmid39791266,
year = {2025},
author = {Kadariya, Y and Sementino, E and Hua, X and Kappes, DJ and Testa, JR},
title = {Modeling Malignant Mesothelioma in Genetically Engineered Mice.},
journal = {Current protocols},
volume = {5},
number = {1},
pages = {e70086},
doi = {10.1002/cpz1.70086},
pmid = {39791266},
issn = {2691-1299},
mesh = {Animals ; *Mesothelioma/genetics/chemically induced/pathology ; Mice ; *Disease Models, Animal ; *Mesothelioma, Malignant/genetics/pathology ; *Lung Neoplasms/genetics/chemically induced/pathology ; Humans ; Asbestos/toxicity ; Mice, Transgenic ; Genetic Engineering ; },
abstract = {Mesothelioma is a lethal cancer of the serosal lining of the body cavities. Risk factors include environmental and genetic factors. Asbestos exposure is considered the principal environmental risk factor, but other carcinogenic mineral fibers, such as erionite, also have a causal role. Pathogenic germline (heritable) mutations of specific genes, especially BAP1, are thought to predispose the individual to mesothelioma in about 10% of cases. Somatic mutations and deletions of specific tumor suppressor genes, particularly BAP1, CDKN2A/B, and NF2, occur frequently in human mesothelioma, and asbestos-exposed mice with heterozygous deletions of any one of these genes have been shown to develop mesothelioma more often and at an accelerated rate than in control animals. Autochthonous mesothelioma mouse models, which are genetically engineered to carry multiple genetic lesions matching those observed in the human disease counterpart, closely resemble the disease phenotype and the extensive inflammatory responses that characterize human mesothelioma. Because autochthonous mice do not require asbestos exposure and form tumors rapidly, these models are invaluable for assessing novel therapeutic strategies in an immunocompetent setting. The overlapping genetic, epigenetic, and immune environments of the tumors observed in these genetically engineered mouse models (GEMMs) and human primary mesothelioma specimens support the clinical relevance of these preclinical models. This article presents protocols for studies of asbestos-induced mesothelioma in GEMMs and non-carcinogenic conditional knockout models of mesothelioma, including an example of a preclinical application. These models are invaluable for understanding the biological underpinnings of mesothelioma and for testing new therapeutics and chemoprevention or interception agents. © 2025 Wiley Periodicals LLC. Basic Protocol 1: Generation of a genetically engineered mouse model (GEMM) with a germline Bap1 knockout allele Basic Protocol 2: Generation of GEMMs with germline Bap1 knock-in alleles Basic Protocol 3: Asbestos carcinogenicity investigations with GEMMs Basic Protocol 4: Preclinical chemoprevention and chemotherapy studies using a GEMM with asbestos-induced mesothelioma Basic Protocol 5: Generation of a GEMM with conditional knockout of Bap1 Basic Protocol 6: Generation of a conditional knockout model of mesothelioma.},
}
@article {pmid39776006,
year = {2025},
author = {Franzoi, IG and Sauta, MD and Bonafede, M and Francioso, G and De Luca, A and Barbagli, F and Granieri, A},
title = {Psychological Distress in Patients With Asbestos-Related Diseases and Their Families: A Systematic Literature Review.},
journal = {Psycho-oncology},
volume = {34},
number = {1},
pages = {e70051},
doi = {10.1002/pon.70051},
pmid = {39776006},
issn = {1099-1611},
mesh = {Humans ; *Caregivers/psychology ; *Asbestos ; *Psychological Distress ; Quality of Life/psychology ; Mesothelioma, Malignant/psychology ; Anxiety/psychology ; Depression/psychology ; Stress, Psychological/psychology ; Occupational Exposure/adverse effects ; },
abstract = {BACKGROUND: Exposure to asbestos in the workplace is currently recognized as one of the leading causes of work-related deaths, with more than half of deaths attributable to cancer.<br><br>AIMS: The aim of this systematic literature review was to investigate the mental health and psychological distress of patients affected by asbestos-related diseases and their caregivers.<br><br>METHODS: The review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The studies were identified in October 2023 by searching four electronic databases: Scopus, Web of Science, PubMed and PsycInfo/PsycArtcicles. Risk of bias was assessed using the JBI checklist.<br><br>RESULTS: Fourteen articles were identified. The studies focused exclusively on the psychological distress of patients with malignant mesothelioma (MM) and their caregivers. MM appears to have traumatic effects on both patients and caregivers, who may experience anxiety and depression, an impoverished emotional life, somatization, social withdrawal, and a deterioration in their quality of life. In addition, a need for information about MM, its progression and associated care tasks was identified, and patients and caregivers reported frequently seeking information from online sources.<br><br>CONCLUSIONS: Our review has shown that there are still few studies addressing psychological distress in MM patients and their caregivers, and none addressing distress in the context of other asbestos-related diseases. The somatopsychic consequences of MM in patients and caregivers should encourage institutions and health professionals to develop assessment and intervention models that are tailored to the specific suffering and needs of MM patients and their caregivers and promote their residual vitality.},
}
@article {pmid39773018,
year = {2025},
author = {Pyana Kitenge, J and Dubbeldam, A and Said-Hartley, Q and Ronsmans, S and Jeebhay, M and Nemery, B},
title = {Asbestos-related diseases in Africa: sentinel cases of mesothelioma and asbestosis from DR Congo.},
journal = {Pulmonology},
volume = {31},
number = {1},
pages = {2449268},
doi = {10.1080/25310429.2024.2449268},
pmid = {39773018},
issn = {2531-0437},
}
@article {pmid39765992,
year = {2024},
author = {Ferrante, P},
title = {Respiratory Diseases with High Occupational Fraction in Italy: Results from the Italian Hospital Discharge Registry (2010-2021).},
journal = {Healthcare (Basel, Switzerland)},
volume = {12},
number = {24},
pages = {},
doi = {10.3390/healthcare12242565},
pmid = {39765992},
issn = {2227-9032},
abstract = {OBJECTIVES: Occupational respiratory diseases represent a major public health concern worldwide. This study analyses the hospitalization costs and characteristics of four major occupational respiratory diseases: malignant mesothelioma (MM), sinonasal cancer (SNC), pneumoconiosis (PN), and hypersensitivity pneumonitis (HP). The findings are situated within the context of Italy's population trends and healthcare system, offering insights into the economic and clinical burden of these diseases.<br><br>STUDY DESIGN: This retrospective, population-based study examines Italian hospitalizations for MM, SNC, PN, and HP during the period 2010-2021. The primary outcomes were the number of hospitalizations, length of stay, and associated cost. Costs were derived from charges linked to diagnosis-related groups (version 24) and major diagnostic category coding systems.<br><br>RESULTS: Though the Italian population is rapidly aging, the annual number and rate of hospitalizations declined by 35% over the study period. SNC hospitalizations aligned with the overall trend, PN and MM experienced faster declines, whereas HP admissions remained steady. MM emerged as the most resource-intensive (EUR 25 million yearly, with 86% attributable to occupation), followed by PN (EUR 10 million, entirely occupational), SNC (EUR 5 million, with EUR 650,000 occupational), and HP (EUR 2 million, with EUR 370,000 occupational). All studied diseases had an average length of stay exceeding the national one. The SNC admissions were the shortest (6.5 days) and least expensive (EUR 3647). In contrast, MM, PN, and HP had a mean length of stay exceeding 10 days, with admission costs averaging EUR 4700 for MM and EUR 4000 for PN and HP. The median age was the highest for PN (78 years) and MM (71 years), while SNC and HP patients had a median age of approximately 65 years.<br><br>CONCLUSIONS: Consistent with their anticipated benefits, Italian workplace health regulations over the last three decades, including the 1992 asbestos ban and D.lgs. 81/2008, are associated with significant reductions in the hospitalization burden and an increased median age at discharge for MM and PN. In contrast, fewer conclusions can be drawn for SNC and HP due to their lower occupational fractions (10-20%). This finding suggests adding an occupational exposure flag in hospital records for acknowledged occupational diseases to enhance surveillance. Finally, this study provides the first estimate of the occupational fraction of hospitalization costs for the studied diseases in Italy.},
}
@article {pmid39758284,
year = {2025},
author = {Bertolotti, M and Tamburro, M and Salzo, A and Cassinari, A and Crivellari, S and Bertolina, C and Farotto, M and Adesso, C and Di Palma, MA and Natale, A and Torregiani, F and Pacileo, G and Maconi, A and Ripabelli, G},
title = {Knowledge and awareness of asbestos risk among General Practitioners: Validation of a questionnaire in an area with a high incidence of asbestos-related diseases.},
journal = {Preventive medicine reports},
volume = {49},
number = {},
pages = {102940},
pmid = {39758284},
issn = {2211-3355},
abstract = {OBJECTIVE: Given the critical role of general practitioners (GPs) in the early diagnosis and management of asbestos-related diseases (ARDs), and the significant history of asbestos fibres pollution in Alessandria Local Health Authority (ASL AL), this project aimed to assess the knowledge and awareness of asbestos risks, as well as the experience in diagnosing ARDs among GPs working in Alessandria province, Northern Italy.<br><br>METHODS: A questionnaire was administered to 216 GPs from all ASL AL territorial districts during 26 Territorial Assistance Equipes (EATs) meetings, held from September 2022 to January 2023. It contained 29 questions covering three main areas: 'knowledge and awareness', 'competence and experience', 'sociodemographic characteristics and workload'.<br><br>RESULTS: Although GPs were aware of the health hazards of asbestos (94&#xa0;%) and the increased risk of mesothelioma from asbestos exposure (92.6&#xa0;%), significant disparities and heterogeneity of knowledge were observed among territorial districts and by comparing Casale Monferrato district with all the others, particularly regarding asbestos exposure routes, reporting of occupational diseases, and mesothelioma latency.<br><br>CONCLUSIONS: This project provides a comprehensive overview of GPs' knowledge, awareness and experience in managing ARDs, providing indications of customised training requirements. This evaluation could be extended to all areas with a history of previous asbestos exposure and provide a useful tool for policy makers to define and plan strategic actions on asbestos. This work could also be adapted to different realities with a history of environmental pollutant exposure other than asbestos, which pose a risk for the development of several diseases.},
}
@article {pmid39751851,
year = {2025},
author = {D'Alonzo, RA and Keam, S and Gill, S and Rowshanfarzad, P and Nowak, AK and Ebert, MA and Cook, AM},
title = {Fractionated low-dose radiotherapy primes the tumor microenvironment for immunotherapy in a murine mesothelioma model.},
journal = {Cancer immunology, immunotherapy : CII},
volume = {74},
number = {2},
pages = {44},
pmid = {39751851},
issn = {1432-0851},
support = {APP1197652//National Health &amp; Medical Research Council with a Centre of Research Excellence/ ; APP1197652//National Health &amp; Medical Research Council with a Centre of Research Excellence/ ; APP1197652//National Health &amp; Medical Research Council with a Centre of Research Excellence/ ; 1163065//Cancer Australia Priority-driven Collaborative Cancer Research Scheme/ ; 1163065//Cancer Australia Priority-driven Collaborative Cancer Research Scheme/ ; },
mesh = {Animals ; Mice ; *Tumor Microenvironment/immunology/radiation effects ; *Immunotherapy/methods ; *Mesothelioma/radiotherapy/immunology/therapy/pathology ; *Disease Models, Animal ; Dose Fractionation, Radiation ; Immune Checkpoint Inhibitors/therapeutic use/pharmacology ; Female ; Mice, Inbred C57BL ; Humans ; Cell Line, Tumor ; Combined Modality Therapy/methods ; },
abstract = {Combination immune checkpoint inhibitors (nivolumab and ipilimumab) are currently a first-line treatment for mesothelioma; however, not all patients respond. The efficacy of treatment is influenced by the tumor microenvironment. Murine mesothelioma tumors were irritated with various radiotherapy doses. Radiotherapy induced vasculature changes were monitored by power Doppler and photoacoustic ultrasound and analyzed via mixed-effects models. Tissue staining was used to investigate the immune cell infiltrate of tumors. The optimal radiotherapy schedule was combined with immune checkpoint inhibitors, and the survival of mice was analyzed. Using low-dose, low-fraction radiotherapy allowed favorable modification of the murine mesothelioma tumor microenvironment. Irradiating tumors with 2 Gy × 5 fractions significantly improved blood flow and reduced hypoxia, consequently increasing the presence of CD8[+] and regulatory T cells in the tumor. Understanding the transient nature of these changes is crucial for optimizing the timing of therapeutic delivery. The combination of radiotherapy with dual immunotherapy (anti-PD-1 plus anti-CTLA-4) proved highly curative when administered concurrently. A diminishing rate of cures was noted with an increasing delay between radiotherapy and subsequent immunotherapy. Concurrent low-dose, low-fraction radiotherapy emerges as a translatable approach for improving the efficacy of immune checkpoint inhibitors in patients.},
}
@article {pmid39747518,
year = {2025},
author = {Nielsen, DM and Hsu, M and Zapata, M and Ciavarra, G and van Zyl, L},
title = {Bayesian analysis of the rate of spontaneous malignant mesothelioma among BAP1 mutant mice in the absence of asbestos exposure.},
journal = {Scientific reports},
volume = {15},
number = {1},
pages = {169},
pmid = {39747518},
issn = {2045-2322},
abstract = {Cancers of the mesothelium, such as malignant mesothelioma (MM), historically have been attributed solely to exposure to asbestos. Recent large scale genetic and genomic functional studies now show that approximately 20% of all human mesotheliomas are causally linked to highly penetrant inherited (germline) pathogenic mutations in numerous cancer related genes. The rarity of these mutations in humans makes it difficult to perform statistically conclusive genetic studies to understand their biological effects. This has created a disconnect between functional and epidemiological studies. However, since the molecular pathogenesis of MM in mice accurately recapitulates that of human disease, this disconnect between functional and epidemiological studies can be overcome by using inbred mouse strains that harbor mutation(s) in genes involved in the disease. Most mouse studies have focused on the effect of asbestos exposure, leaving the effects of genetic mutations in the absence of exposure understudied. Here, using existing peer-reviewed studies, we investigate the rate of spontaneous MM among mice with and without germline genetic mutations, in the absence of asbestos exposure. We leveraged these published data to generate a historical control dataset (HCD) to allow us to improve statistical power and account for genetic heterogeneity between studies. Our Bayesian analyses indicate that the odds of spontaneous MM among germline BAP1 mutant mice is substantially larger than that of wildtype mice. These results support the existing biological study findings that mesotheliomas can arise in the presence of pathogenic germline mutations, independently of asbestos exposure.},
}
@article {pmid39737233,
year = {2024},
author = {Franzoi, IG},
title = {Rediscovering one's own voice in a brief psychoanalytic group intervention aimed at malignant mesothelioma patients and their families.},
journal = {Frontiers in psychology},
volume = {15},
number = {},
pages = {1471057},
pmid = {39737233},
issn = {1664-1078},
abstract = {Occupational and/or environmental exposure to asbestos can lead to clinical manifestation of a variety of diseases, including malignant mesothelioma (MM), a rare cancer with a particularly high incidence rate in areas with a long history of asbestos processing. This paper aims to describe brief psychoanalytic groups (BPGs), which is an intervention model aimed at MM patients and their families in the early stages of the disease, shortly after diagnosis. The BPG model comprises 12 weekly sessions of 1 h each, co-led by two psychoanalytically oriented psychotherapists who are trained in working with cancer patients and their families and in the specifics of the BPG setting. Reflections in this paper on the BPGs will attempt to trace the voice of the group in clinical material, paying attention to its horizontal unfolding as a melodic development over time and its vertical unfolding as a harmonic interweaving between the different individual voices, which, even when opposed to each other, can find a generative interlocking of meaning. In the BPG, then, it is possible to set in motion transformations that allow one to embrace the different and diverse affective colorations of experience, evolve toward a thinking that is capable of incorporating intense emotions related to death and grief, follow healthier paths of interaction on an intrapsychic and interpersonal level, and find traces of one's own vitality.},
}
@article {pmid39731918,
year = {2024},
author = {Chin, WL and Cook, AM and Chee, J and Principe, N and Hoang, TS and Kidman, J and Hmon, KPW and Yeow, Y and Jones, ME and Hou, R and Denisenko, E and McDonnell, AM and Hon, CC and Moody, J and Anderson, D and Yip, S and Cummins, MM and Stockler, MR and Kok, PS and Brown, C and John, T and Kao, SC and Karikios, DJ and O'Byrne, KJ and Hughes, BGM and Lake, RA and Forrest, ARR and Nowak, AK and Lassmann, T and Lesterhuis, WJ},
title = {Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy.},
journal = {Cell reports. Medicine},
volume = {},
number = {},
pages = {101882},
doi = {10.1016/j.xcrm.2024.101882},
pmid = {39731918},
issn = {2666-3791},
abstract = {Platinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers to guide treatment decisions. Here, we combine time course RNA sequencing (RNA-seq) of peripheral blood mononuclear cells with pre-treatment tumor transcriptome data from the single-arm, phase 2 DREAM trial (N = 54). Single-cell RNA-seq and T cell receptor sequencing (TCR-seq) reveal that CD8[+] T effector memory (TEM) cells with stem-like properties are more abundant in peripheral blood of responders and that this population expands upon treatment. These peripheral blood changes are linked to the transcriptional state of the tumor microenvironment. Combining information from both compartments, rather than individually, is most predictive of response. Our study highlights complex interactions between the tumor and immune cells in peripheral blood during objective tumor responses to chemoimmunotherapy. This trial is registered with the Australian New Zealand Clinical Trials Registry, number ACTRN12616001170415.},
}
@article {pmid39697085,
year = {2024},
author = {Kurzhunbaeva, Z and Dzhusupov, K and Spinazzè, A and Visonà, SD and Sulaimanova, C and Kasymov, O and Belluso, E and Colosio, C},
title = {Human Exposure to Asbestos in Central Asian Countries and Health Effects: A Narrative Review.},
journal = {La Medicina del lavoro},
volume = {115},
number = {6},
pages = {e2024042},
doi = {10.23749/mdl.v115i6.15453},
pmid = {39697085},
issn = {0025-7818},
mesh = {Humans ; *Asbestos/adverse effects ; Environmental Exposure/adverse effects ; Occupational Exposure/adverse effects ; Asia, Central/epidemiology ; Asbestosis/epidemiology/etiology ; Kazakhstan/epidemiology ; Mesothelioma/etiology/epidemiology ; },
abstract = {The discovery of the detrimental effects of asbestos on human health came long after its widespread use, with the first scientific evidence of asbestos-related diseases emerging in the late 19th and early 20th centuries. Despite efforts to ban its use, asbestos continues to be mined and used in Central Asia (as well as in Russia, China, and other countries). To gain a deeper understanding of the situation in Central Asia, we have conducted a systematic review of scientific literature on the use of asbestos, exposure assessment, and health consequences of asbestos exposure in this geographic area. This review encompasses studies about exposure assessments, epidemiological data, and biochemical or clinical surveys conducted in Kazakhstan, Uzbekistan, Tajikistan, Turkmenistan, and Kyrgyzstan. A total of 18 articles met the inclusion criteria, and their content is summarised in this review, which represents the first attempt to systematically examine research on asbestos and its impact on the health of workers and the general population in Central Asia countries, including literature published in Russian and English. The findings here highlighted the substantial limitations of the currently available knowledge about the impact of asbestos on health in this geographical area.},
}
@article {pmid39686704,
year = {2024},
author = {Meisenkothen, C},
title = {Underestimation of Chrysotile Health Risk due to Under-ascertainment of Mesothelioma: Evidence from a Century of Connecticut's Experience with the "Magic Mineral".},
journal = {New solutions : a journal of environmental and occupational health policy : NS},
volume = {},
number = {},
pages = {10482911241303469},
doi = {10.1177/10482911241303469},
pmid = {39686704},
issn = {1541-3772},
abstract = {Over a century ago, Connecticut industry began using chrysotile asbestos. Chrysotile found a home in several factories that used it exclusively or predominantly. The occurrence of mesothelioma in 4 of those factories is the subject of this paper-2 have been reported previously and are updated here with new information; one was the subject of a prior internal corporate study that was never published; one is reported here for the first time. Twenty-four cases of mesothelioma have been identified among these workers, including several who had no known amphibole exposure. It is likely that additional cases of mesothelioma have been missed. The full scale of the hazard may never be completely known, but reports such as the present one add to the weight of evidence that chrysotile causes mesothelioma in humans and that the full extent of the epidemic is probably wider than retrospective studies have revealed. Continued vigilance is required.},
}
@article {pmid39682143,
year = {2024},
author = {Stella, S and Ceresoli, GL and Dallari, B and Barile, R and Maisenti, F and Rugarli, S and Marinaccio, A and Consonni, D and Mensi, C},
title = {Mesothelioma of the Tunica Vaginalis Testis: Diagnostic and Therapeutic Management. A Comprehensive Review, 1982-2024.},
journal = {Cancers},
volume = {16},
number = {23},
pages = {},
doi = {10.3390/cancers16233956},
pmid = {39682143},
issn = {2072-6694},
support = {BRIC INAIL ID 66/2022 [Grant PB-0184]//INAIL: Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro/ ; },
abstract = {BACKGROUND: Mesothelioma of the tunica vaginalis testis (MTVT) is an extremely rare and aggressive cancer. The diagnosis and management of MTVT is complex, and no standard treatment protocol is available.<br><br>METHODS: We conducted a systematic literature review from 1 January 1982 to 14 March 2024 using PubMed to collect all the available case reports and case series. A descriptive analysis of patient characteristics with clinical presentation, diagnostic work-up, therapeutic management, and past asbestos exposure was performed. Survival times of patients treated with different therapeutic approaches were evaluated.<br><br>RESULTS: Overall, 289 patients with MTVT were included in our analysis. The most common clinical presentations were scrotal/testicular swelling or mass (187 patients, 65%) and the presence of hydrocele (159, 55%). Imaging evaluation, mostly with ultrasonography or CT scan, was reported in two-thirds of cases. Radical surgery (216 patients, 75%) with orchiectomy and, in select cases, hemiscrotectomy and inguinal lymphadenectomy was the most frequent therapeutic approach. A minority of patients (49, 17%) received adjuvant therapy after surgery (radiotherapy, chemotherapy, or a combination of the two), with no evidence of survival improvement.<br><br>CONCLUSIONS: No standard guidelines for MTVT are available so far. Radical surgery following accurate radiological staging should be the mainstay of treatment. The role of adjuvant treatments remains undefined. Due to its rarity, MTVT should be treated in referral centers, and patients' data should be collected in a dedicated register in order to improve the knowledge of this exceedingly rare disease and establish optimal diagnostic and therapeutic management.},
}
@article {pmid39679483,
year = {2024},
author = {Taiano, L and Porzio, A and Massari, S and Iavicoli, I and Palladino, R and Menegozzo, S and Mensi, C and Binazzi, A and Menegozzo, M and Marinaccio, A},
title = {[Mortality due to mesothelioma and asbestosis in Campania Region (Southern Italy): perspectives for reducing asbestos exposure].},
journal = {Epidemiologia e prevenzione},
volume = {48},
number = {6},
pages = {429-437},
doi = {10.19191/EP24.6.A754.134},
pmid = {39679483},
issn = {1120-9763},
mesh = {Humans ; Italy/epidemiology ; *Asbestosis/mortality ; Female ; Male ; *Mesothelioma/mortality ; *Asbestos/adverse effects ; Aged ; Middle Aged ; Environmental Exposure/adverse effects ; Lung Neoplasms/mortality ; Aged, 80 and over ; Adult ; },
abstract = {OBJECTIVES: to provide an overview of the geographical distribution of mesothelioma and asbestosis deaths in the Campania Region (Southern Italy) occurred from 2005 to 2018 and to identify areas at higher risk.<br><br>DESIGN: for each municipality, Standardized Mortality Ratios (SMRs) for mesothelioma and asbestosis have been estimated from the mortality data provided by the Italian National Institute of Statistics (Istat). Deaths for which mesothelioma and asbestosis were identified as the underlying causes, according to the classification system ICD-10 codes (C45 and J61, respectively), were included. Expected cases were estimated applying age- and gender-specific mortality rates in Campania on resident populations of each municipality. Furthermore, the association between the municipal SMR and the local socioeconomic deprivation index based on the 2011 General Census of Population and Housing was also analysed.<br><br>SETTING AND PARTICIPANTS: Campania Region.<br><br>MAIN OUTCOMES MEASURES: the study outcomes were standardized mortality ratios for mesothelioma and asbestosis and the identification of territorial subareas.<br><br>RESULTS: a total of 998 deaths attributed to mesothelioma and 62 to asbestosis were identified. No cases of death due to mesothelioma or asbestosis were reported in the province of Benevento. A significant increase in mortality due to mesothelioma was observed across 34 municipalities. These findings show that several municipalities within the province of Naples display a high increase in mortality due to mesothelioma and asbestosis, with 506 deaths in total and 246 cases recorded in the municipality of Naples against 178,37 expected (SMR 1,38; 90%CI 1.24-1.53). In 15 municipalities, a notable increase in mortality for asbestosis was recorded; in Naples, 28 cases occurred (SMR 2,51; 90%CI 1.84-3.42). The overlap between mortality maps for mesothelioma and asbestosis confirms the existence of areas subjected to definite and prolonged asbestos exposure. Additionally, a correlation with the deprivation index was noted: the pooled SMR by quintiles increases with higher quintiles of the deprivation index, for both mesothelioma and asbestosis.<br><br>CONCLUSIONS: results highlight the crucial need for epidemiological surveillance of asbestos-related diseases in Campania. Actively searching out for new cases of mesothelioma in the entire region is a crucial task in primary prevention of occupational, environmental, and domestic exposures to asbestos.},
}
@article {pmid39668371,
year = {2024},
author = {Tibaldi, E and Gnudi, F and Mandrioli, D and Bruno, C and Zona, A and Fazzo, L and Comba, P},
title = {Pathological characterization of lung fibrosis in Sprague-Dawley rats treated with fluoro-edenite fibres by intrapleural injection.},
journal = {Journal of occupational medicine and toxicology (London, England)},
volume = {19},
number = {1},
pages = {45},
pmid = {39668371},
issn = {1745-6673},
abstract = {BACKGROUND: An increased incidence of pleural mesotheliomas in Biancavilla (Italy) was attributed to the environmental exposure to fluoro-edenite (FE). Results from the Ramazzini Institute (RI) in vivo long-term study confirmed the evidence that exposure to FE fibres is correlated with an increase of malignant pleural mesotheliomas in Sprague-Dawley rats. Recently asbestosis-like features were substantiated in Biancavilla residents without known occupational exposures. Aim of this work was to establish whether FE induce lung fibrosis with a pathogenetic mechanism similar to other asbestiform fibres.<br><br>METHODS: Original slides from the RI study were systematically re-examined to characterize the FE-induced lesions. Quantitative analysis of lung fibrosis was assessed following the Ashcroft method. Immunohistochemical analysis of protein involved in fibrotic responses and histochemical staining for FE-fibres identification were performed.<br><br>RESULTS: Like asbestos, FE caused fibrotic lesions, pleural plaques or nodules and mesotheliomas. A significant increase of lung fibrosis (p&#x2009;<&#x2009;0.001) was observed in the FE-treated groups compared to untreated controls. In the fibrotic responses to FE, vimentin was the most expressed protein, followed by collagen-I and alpha-SMA. Finally, ferruginous bodies, characterized by iron deposits and ferritin expression, were observed in FE-induced lesions.<br><br>CONCLUSIONS: This study confirmed that FE exposure promotes the onset of fibrotic lesions at pleural level, as fibrous plaques or nodules and fibrosis, through a mechanism similar to other form of asbestos. These results combined with epidemiological study reported in Biancavilla residents, corroborate the need to promote health and epidemiological surveillance plans of respiratory diseases in population living in FE contaminated sites.},
}
@article {pmid39611075,
year = {2024},
author = {Fadl, L and Fadl, M and Fadl, O and Thaplar G Gouda, SG and Mirza, H},
title = {A Case Report of Peritoneal Mesothelioma as an Acute Abdomen Mimic: A Rare Presentation and Diagnostic Challenges.},
journal = {Cureus},
volume = {16},
number = {11},
pages = {e74598},
pmid = {39611075},
issn = {2168-8184},
abstract = {Malignant peritoneal mesothelioma (MPM) is a rare and aggressive cancer often linked to asbestos exposure. This case report presents a 60-year-old man with a history of asbestos exposure who developed MPM, initially presenting with acute abdominal pain, an uncommon mimic of the acute abdomen. Diagnosing MPM is challenging due to its vague symptoms, often leading to delayed diagnosis. Additionally, the patient developed internal jugular vein thrombosis, a rare complication associated with malignancies. This case highlights the rare presentation of peritoneal mesothelioma as an acute abdomen mimic, the diagnostic complexities associated with MPM, and the rare type of thromboembolic event in this case.},
}
@article {pmid39609252,
year = {2024},
author = {Visonà, SD and Untalan, M and Bertoglio, B and Capella, S and Belluso, E and Billò, M and Ivic-Pavlicic, T and Taioli, E},
title = {Asbestos Burden in Lungs of Subjects Deceased From Mesothelioma Who Lived in Proximity to an Asbestos Factory: A Topographic Post-Mortem SEM-EDS Study.},
journal = {American journal of industrial medicine},
volume = {},
number = {},
pages = {},
doi = {10.1002/ajim.23680},
pmid = {39609252},
issn = {1097-0274},
support = {//The authors received no specific funding for this work./ ; },
abstract = {BACKGROUND: Asbestos exposure and its pathological consequences, especially malignant mesothelioma (MM) still represent a major public health problem on a global scale. After the ban of asbestos in most western countries, nonoccupational exposure plays an essential role in MM pathogenesis. However, few studies have quantified asbestos lung burden after environmental exposure. The main objective of this work is to understand if asbestos lung content is different between occupationally and environmentally exposed individuals, and if the distance between the subjects' residences and the source of exposure is significantly associated with the asbestos lung burden.<br><br>METHODS: In this retrospective, observational study we quantified, with analytical scanning electron microscopy, asbestos content in lungs of individuals deceased from MM between 2005 and 2019, who were exposed to asbestos (occupationally and/or environmentally) in Broni, a small town in northern Italy where an important asbestos-cement plant operated until 1993.<br><br>RESULTS: We analyzed asbestos lung content of 77 subjects. We found that the asbestos lung content in MM patients who lived around the asbestos factory was as high as that seen in occupationally exposed individuals; this holds true in residents up to 10&#x2009;km radius from the factory. We found no significant associations between the residence duration/distance ratio and asbestos lung burden.<br><br>CONCLUSIONS: This study suggests that heavy asbestos pollution involves not only the area adjacent to the factory, but the entire town of Broni and the surroundings. This is alarming if we consider that most asbestos factories still active in some countries are located close to towns and dwellings.},
}
@article {pmid39607779,
year = {2024},
author = {Faccioli, E and Dell'Amore, A and Lorenzoni, G and Schiavon, M and Canu, G and Pasello, G and Zambello, G and Sepulcri, M and Sambataro, V and Labella, F and Giraudo, C and Gregori, D and Calabrese, F and Rea, F},
title = {Surgery for pleural mesothelioma in multimodality setting: comparison between surgical techniques in a high-volume center.},
journal = {European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery},
volume = {},
number = {},
pages = {},
doi = {10.1093/ejcts/ezae431},
pmid = {39607779},
issn = {1873-734X},
abstract = {OBJECTIVES: Pleural mesothelioma (PM) is an aggressive disease linked to asbestos exposure, presenting significant treatment challenges. The recommended approach is multimodal treatment, even if the concept of resectable PM and the superiority of one surgical technique over the other [(extended) pleurectomy decortication [(E)PD] vs extra-pleural pneumonectomy (EPP)] are matter of debates. The aim of this study is to compare the two techniques in terms of short- and long-term outcomes at a high-volume center.<br><br>METHODS: Clinical data from PM patients who underwent radical surgery [(E)PD and EPP] between 1994 and 2022 were collected. A propensity score weighting approach was used for non-random intervention allocation. Survival distribution was estimated using Kaplan-Meier method and the association with outcomes was evaluated using a weighted Cox Proportional Hazard Models.<br><br>RESULTS: Among 254 patients, 125 (49%) underwent EPP and 129 (51%) (E)PD. The 90-day mortality was higher in the EPP group (7.2% vs 0%; p&#x2009;=&#x2009;0.01). No difference in 1-,3- and 5-year survival was found: 65.8%, 26%, 17% for EPP and 75.5%, 39.7% and 21.3% for (E)PD; p&#x2009;=&#x2009;0.39). The multivariable weighted Cox model identified no increased risk of death (HR 1.25; p&#x2009;=&#x2009;0.49) or recurrence (HR 1.05; p&#x2009;=&#x2009;0.858) in the EPP group. Pre-operative total lung capacity (TLC) was significantly associated with a reduced risk of death (HR 0.96; p&#x2009;=&#x2009;0.023) and recurrence (HR 0.97; p&#x2009;=&#x2009;0.019) at follow-up while preoperative disease burden to a higher risk of recurrence (HR 1.01; p&#x2009;=&#x2009;0.02).<br><br>CONCLUSIONS: Our experience showed acceptable short- and long-term outcomes in both procedures, making EPP still an option only for carefully selected patients at high volume center. Surgery, although recently debated, should be performed exclusively in expert centers to minimize post-operative risks. The identification of new prognostic factors is crucial for better selecting patients who may benefit from surgery within the context of multimodal treatment.},
}
@article {pmid39604235,
year = {2024},
author = {Chen, YQ and Gao, ZB and Shen, W and Ying, SB and He, XL and Zhang, X and Jiang, ZQ and Lou, JL},
title = {[The prognostic value of BAP1 protein loss in patients with malignant mesothelioma].},
journal = {Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases},
volume = {42},
number = {11},
pages = {815-820},
doi = {10.3760/cma.j.cn121094-20240112-00016},
pmid = {39604235},
issn = {1001-9391},
support = {KYYB202113//The Basic Scientific Research Business Fee and Basic Scientific Research Plan of Hangzhou Medical College/ ; 81973011//The National Natural Science Foundation of China/ ; //The Key Discipline of Zhejiang Province in Public Health and Preventive Medicine (First Class, Category A) of Hangzhou Medical College/ ; },
mesh = {Humans ; *Ubiquitin Thiolesterase/metabolism ; Female ; *Tumor Suppressor Proteins/metabolism ; Male ; Middle Aged ; *Mesothelioma, Malignant/metabolism ; Prognosis ; *Lung Neoplasms/metabolism ; Aged ; *Mesothelioma/metabolism ; Survival Rate ; Kaplan-Meier Estimate ; Proportional Hazards Models ; Adult ; },
abstract = {Objective: To explore the prognostic value of BRCA1-associated protein 1 (BAP1) expression loss in patients with malignant mesothelioma (MM) . Methods: A total of 82 MM patients from January 1998 to December 2017 in Zhejiang Province were selected to detect the expression of BAP1 protein by immunohistochemical analysis. Kaplan-Meier method was used to draw the survival curve, and multivariate Cox proportional risk model was used to analyze the factors affecting the survival rate. Results: Among 82 MM patients, 61 (74.4%) were female, aged (57±11) years. BAP1 protein expression was deficient in 39 patients (47.6%). The survival rate was correlated with the loss of BAP1 protein expression and age (χ(2)=5.27, 5.66, P=0.022, 0.017). Subgroup analysis showed that loss of BAP1 protein expression was associated with better prognosis in MM patients <57 years of age, female, pleural MM, epithelial MM, and treated with drugs or surgery (P<0.05). Multivariate model results showed that positive expression of BAP1 protein (HR=3.75, 95%CI: 2.23-6.30, P<0.001) and age ≥57 years (HR=1.66, 95% CI: 1.01-2.72, P=0.049) were risk factors for survival in patients with MM. Conclusion: Loss of BAP1 protein expression may be an independent prognostic factor in patients with MM, which is associated with longer survival.},
}
@article {pmid39569577,
year = {2024},
author = {Angelini, A and Martini, A and Masala, G},
title = {[Update. Inventory of occupational exposure to asbestos with particular reference to Tuscan worker].},
journal = {Epidemiologia e prevenzione},
volume = {48},
number = {6},
pages = {1-128},
doi = {10.19191/EP24.6.S1.128},
pmid = {39569577},
issn = {1120-9763},
mesh = {Italy/epidemiology ; *Asbestos/adverse effects ; Humans ; *Occupational Exposure/adverse effects ; Occupational Diseases/epidemiology ; Lung Neoplasms/epidemiology/etiology/chemically induced ; Asbestosis/epidemiology/etiology ; Mesothelioma/epidemiology/etiology ; Carcinogens ; Population Surveillance ; },
abstract = {This Catalogue is a collection of information on the use of raw asbestos and asbestos-containing materials used in several industries and occupational activities, with particular attention to the situation of Tuscany, a region of Central Italy. The work was developed at the Institute for Cancer Research, Prevention and Clinical Network (ISPRO) of Florence, where epidemiologic research and surveillance activities have been developing since 1988 and where the coordination and evaluation of the regional health surveillance programme provided to past asbestos workers started in 2016 and is still ongoing. The Catalogue aims at being a working tool for all health professionals engaged in examining and classifying the occupational asbestos exposures of subjects both affected by diseases that could be associated to this carcinogen and examined within the regional health surveillance programme. It is necessary for the health personnel engaged in the above-mentioned activities to know or to have the possibility to find exact and detailed data on asbestos exposure by occupational sector. These data are briefly described in the 29 factsheets this Catalogue consists of. In each factsheet, the presence and every use of asbestos are described, with reference to a precise occupational sector. Several occupational sectors can be considered together because of analogies on asbestos exposure. Occupations are considered on the basis of existing evidence on the use of raw asbestos or asbestos-containing materials (as semi-finished or finished products or as auxiliary materials in production processes). Besides the presence and use of asbestos, a description of the possible exposures of workers is reported. Sources of information were scientific and grey literature as well as the 8,097 occupational histories of mesothelioma registered by the specific Tuscan registry. Some factsheets have been revised and enhanced by Italian experts on the asbestos exposure with a specific competence in the examined sectors. Each factsheet includes also questions to be addressed to workers in order to examine in depth their possible asbestos exposure. For those who would like to expand their knowledge on this topic, references are reported both at the end of each factsheet and at the end of the volume. In all industrialized countries, also in those which have not already banned asbestos use, a decrease in the use of this material and in the relative exposure have been observing since the end of the Seventies, few years after the general consensus within the scientific community on asbestos carcinogenicity. This decreasing trend has been becoming greater and greater since the end of the Eighties, when more restrictive regulations have been approved and applied, especially in occupational settings. Nevertheless, nowadays asbestos-related diseases are still diagnosed due to past exposures, although during next decade a decreasing incidence of malignant mesothelioma - the cancer most specifically related to this carcinogen and characterized by a very bad prognosis and the longest latency - could be observed. Particular attention will be paid to jobs regarding renovation of old buildings containing asbestos and to decontamination activities. In conclusion, this Catalogue is a working tool - although it is not exhaustive and could be upgraded with new information - for all professionals engaged in asbestos risk prevention activities as health personnel, personnel of insurance companies, employers, and employee representatives.},
}
@article {pmid39568634,
year = {2024},
author = {Yilmaz, ME and Rashidfarokhi, M and Pollard, K and Durmus, N and Keserci, S and Sterman, DH and Arslan, AA and Shao, Y and Reibman, J},
title = {Mesothelioma Cases in the World Trade Center Survivors.},
journal = {Annals of case reports},
volume = {9},
number = {2},
pages = {},
pmid = {39568634},
issn = {2574-7754},
abstract = {OBJECTIVES: The destruction of the World Trade Center (WTC) towers in New York City on September 11, 2001 (9/11), released approximately 1 million tons of pulverized particulate matter throughout southern Manhattan and areas in Brooklyn, exposing community members and responders to high levels of potentially toxic environmental particles. Asbestos exposure was a health concern because of its use in certain sections of the WTC towers. Malignant mesothelioma, originating from the lining cells (mesothelium) of the peritoneal and pleural cavities, is one complication associated with asbestos exposure.<br><br>METHODS: The WTC Environmental Health Center (WTC EHC) is a treatment and surveillance program for community members (Survivors) exposed to WTC dust and fumes.<br><br>RESULTS: In this report, we describe four cases of mesothelioma in the WTC EHC as of July 1st, 2023. Two of our patients have been diagnosed with peritoneal mesothelioma and two patients have been diagnosed with pleural mesothelioma.<br><br>CONCLUSION: Given the known delay in the development of mesotheliomas after asbestos exposure, we provide information on these early mesothelioma cases to enhance the understanding of the adverse health effects of WTC exposures on the local community.},
}
@article {pmid39558529,
year = {2024},
author = {Willis, VJ and Levin, JL and Nessim, DE},
title = {A Review of Job Assignments and Asbestos Workplace Exposure Measurements for TAWP Mesothelioma Deaths Through 2011.},
journal = {American journal of industrial medicine},
volume = {},
number = {},
pages = {},
doi = {10.1002/ajim.23675},
pmid = {39558529},
issn = {1097-0274},
support = {//This study was supported by the Jesse Jones Distinguished Professorship of Occupational Health Sciences Endowment, University of Texas at Tyler Health Science Center Occupational and Environmental Medicine Residency Program./ ; },
abstract = {INTRODUCTION: Asbestos workers have a higher risk of developing mesothelioma; however, few studies have looked at specific jobs and job locations within asbestos factories. The purpose of this study was to investigate asbestos exposure in different job locations of the Tyler, Texas asbestos plant to determine if there was a relationship between the duration of exposure and air fiber concentration burden in workers who developed pleural versus peritoneal mesothelioma.<br><br>METHODS: This study used a patient information database to compile secondary data on 23 workers who died from mesothelioma through 2011. The airborne fiber exposure burdens for each of the 23 workers were estimated and then stratified by job location category and by type of mesothelioma for analysis.<br><br>RESULTS: Most of the worker cases were assigned to the forming area which had the overall highest fiber concentration of all the plant's job locations. Workers who developed pleural mesothelioma spent the most time in the packing and miscellaneous locations, whereas workers who developed peritoneal mesothelioma worked mostly in the forming and miscellaneous locations. There were significant differences in days worked and estimated airborne exposure fiber burden between the pleural and peritoneal mesothelioma cases in the forming and curing locations.<br><br>CONCLUSION: Results from this study reiterate the association between occupational asbestos exposure and mesothelioma, emphasizing the importance of concentration of respirable asbestos dust levels and duration of exposure.},
}
@article {pmid39539262,
year = {2024},
author = {Ebrahimi, A and Ak, G and Özel, C and İzgördü, H and Ghorbanpoor, H and Hassan, S and Avci, H and Metintaş, M},
title = {Clinical Perspectives and Novel Preclinical Models of Malignant Pleural Mesothelioma: A Critical Review.},
journal = {ACS pharmacology &amp; translational science},
volume = {7},
number = {11},
pages = {3299-3333},
doi = {10.1021/acsptsci.4c00324},
pmid = {39539262},
issn = {2575-9108},
abstract = {Pleural mesothelioma (PM), a rare malignant tumor explicitly associated with asbestos and erionite exposures, has become a global health problem due to limited treatment options and a poor prognosis, in which the median life expectancy varies depending on the method of treatment. However, the importance of early diagnosis is emphasized, and the practical methods have not matured yet. This study provides a critical overview of PM, addressing various aspects like epidemiology, etiology, diagnosis, treatment options, and the potential use of advanced technologies like microfluidic chip-based models for research and diagnosis. It initially begins with fundamentals of clinical aspects and then discusses the identification of disease-specific biomarkers in patients' serum or plasma samples, which could potentially be used for early diagnosis. A detailed investigation of the sophisticated preclinical models is highlighted. Recent three-dimensional (3D) model accomplishments, including microarchitecture modeling by transwell coculture, spheroids, organoids, 3D bioprinting constructs, and ex vivo tumor slices, are discussed comprehensively. On-chip models that imitate physiological processes, such as detection chips and therapeutic screening chips, are assessed as potential techniques. The review concludes with a critical and constructive discussion of the growing interest in the topic and its limitations and suggestions.},
}
@article {pmid39534944,
year = {2024},
author = {Wu, Y and Zhao, Y and Yu, L and Wang, R and Feng, W and Wu, Y and Wang, L and Chen, H and He, Z and Wang, Q},
title = {Case report: targeted therapy of malignant pleural mesothelioma with anaplastic lymphoma kinase receptor tyrosine kinase gene fusion mutation by crizotinib.},
journal = {The Journal of international medical research},
volume = {52},
number = {11},
pages = {3000605241287320},
doi = {10.1177/03000605241287320},
pmid = {39534944},
issn = {1473-2300},
mesh = {Humans ; *Crizotinib/therapeutic use ; Female ; *Anaplastic Lymphoma Kinase/genetics ; *Mesothelioma, Malignant/drug therapy/genetics/pathology ; *Mutation ; *Lung Neoplasms/genetics/drug therapy/pathology ; *Pleural Neoplasms/genetics/drug therapy/pathology ; *Protein Kinase Inhibitors/therapeutic use ; *Mesothelioma/genetics/drug therapy/pathology ; Pyridines/therapeutic use ; Receptor Protein-Tyrosine Kinases/genetics ; Pyrazoles/therapeutic use ; Molecular Targeted Therapy ; Middle Aged ; Gene Fusion ; },
abstract = {Malignant mesothelioma is a rare highly invasive tumour originating from the mesothelial cells of the pleura, peritoneum and pericardium. Malignant pleural mesothelioma (MPM) is the most common type in all malignant mesothelioma. The onset of MPM is associated with exposure to asbestos and it can have an incubation period of up to 40 years. The incidence of MPM has been increasing worldwide in recent years, so more attention has been focused on its diagnosis, treatment and prognosis. Activating mutations, amplifications and fusions/rearrangements of the anaplastic lymphoma kinase receptor tyrosine kinase (ALK) gene are commonly seen in patients with non-small cell lung cancer. However, it is rare in MPM. This current case report describes a female patient with advanced MPM with an ALK gene fusion mutation. In this particular case, treatment with crizotinib demonstrated some initial efficacy, which suggests that this might be a promising strategy for patients with advanced MPM with an ALK gene mutation. This required further research and evaluation in the future.},
}
@article {pmid39516654,
year = {2023},
author = {Gold, LT and Bray, SE and Kernohan, NM and Henderson, N and Nowicki, M and Masson, GR},
title = {The amino-acid stress sensing eIF2α kinase GCN2 is a survival biomarker for malignant mesothelioma.},
journal = {BJC reports},
volume = {1},
number = {1},
pages = {4},
pmid = {39516654},
issn = {2731-9377},
support = {119615//Tenovus/ ; },
abstract = {BACKGROUND: Malignant mesothelioma is a tumour that is strongly associated with a history of asbestos exposure, and which derives from mesothelial cells that line the serous cavities of the body. The tumour most commonly arises in the pleural cavity, but can also arise in the pericardium, peritoneum, and tunica vaginalis. At present the lesion has a very poor prognosis and is an incurable form of cancer with median survival times of up to 19 months being quoted for some histological subtypes. A large proportion of mesotheliomas have been shown to be arginine auxotrophic, leading to new research for therapeutics which might exploit this potential vulnerability.<br><br>METHODS: We measured the levels of General Control Non-derepressible 2 (GCN2) protein in malignant mesothelioma tumour samples and determined whether these levels correlate with clinical outcomes.<br><br>RESULTS: We observed that the expression levels of GCN2 correlated with patient survival and was an independent prognostic variable in pairwise comparisons with all available clinical data.<br><br>CONCLUSION: These findings suggest that GCN2 levels provides prognostic information and may allow for stratification of care pathways. It may suggest that targeting GCN2 is a viable strategy for mesothelioma therapy development.},
}
@article {pmid39514167,
year = {2024},
author = {Guglielmo, P and Crivellaro, C and Castello, A and Della Corte, CM and Pagano, M and Marchesi, S and Occhipinti, M and Zucali, PA and Evangelista, L},
title = {Emerging Radiopharmaceuticals in Pet Imaging for Mesothelioma: A Review of [[18]F]FDG Alternatives.},
journal = {Molecular diagnosis &amp; therapy},
volume = {},
number = {},
pages = {},
pmid = {39514167},
issn = {1179-2000},
abstract = {Mesothelioma is a malignant tumor associated primarily with asbestos exposure, characterized by an aggressive nature and poor prognosis. Accurate diagnosis, staging, and monitoring of therapeutic response are crucial for effective patient management. Along with a computed tomography (CT) scan, fluorodeoxyglucose labeled with fluorine-18 ([[18]F]FDG) positron emission tomography (PET) is commonly used in mesothelioma evaluation. However, it has some limitations, including lower sensitivity after pleurodesis and poor accuracy for involved lymph node evaluation. Thus, there is the need to explore other agents. The aim of the present review is to analyze the current literature on the use of alternative radiopharmaceuticals for PET imaging in patients with mesothelioma. A comprehensive search of scientific databases (PubMed, Scopus, and Web of Science) for studies published in the last decade was performed by using the following keywords: "mesothelioma" AND "PET" AND "PET/CT" "radiopharmaceuticals", "[[18]F]FDG alternatives". Articles focused solely on [[18]F]FDG, non-English publications or preclinical studies, reviews, meeting abstracts, letters to the editors, and editorials were excluded. A qualitative assessment was made by using the Critical Appraisal Skills Programme (CASP) checklist for diagnostic test studies, when applicable. In total, 14 papers were selected; in seven articles more than five patients were enrolled, while the other seven were only clinical cases (enrolling up to two subjects). [[18]F]/gallium-68 ([[68]Ga])-labeled fibroblast activation protein inhibitor (FAPI) compounds, [[18]F]Fluorothymidine ([[18]F]FLT), methionine labeled with carbon-11 ([[11]C]MET), and fluoromisonidazole labeled with fluorine-18 ([[18]F]FMISO) PET/CT were the alternative agents used most often. In 12 articles, [[18]F]FDG PET/CT was used as a comparator imaging modality. Detection rate of [[18]F]FDG was similar to the other radiopharmaceuticals ([[68]Ga]/[18F]-labeled FAPI compounds, [[18]F]FLT, [[18]F]FMISO, [[11]C]MET, and [[68]Ga]-Pentaxifor), although radiolabeled FAPI seems to exhibit a higher diagnostic performance. [[18]F]FDG is still a valuable agent in patients with mesothelioma. However, radiolabeled FAPI appears to be promising and its theranostic properties should therefore be further assessed.},
}
@article {pmid39507169,
year = {2024},
author = {Lief, S and Patibandla, S and Ansari, AZ and Bhatt, N and Gulraiz, A and Beauti, SM and Ali, R},
title = {Ascites as a Rare Manifestation of Malignant Peritoneal Mesothelioma: A Case Report.},
journal = {Cureus},
volume = {16},
number = {10},
pages = {e70982},
doi = {10.7759/cureus.70982},
pmid = {39507169},
issn = {2168-8184},
abstract = {Malignant peritoneal mesothelioma (MPM) is an aggressive neoplasm that originates from the mesothelial cells lining the parietal peritoneum or visceral peritoneum and extensively spreads within the abdominal cavity. It is a rare malignancy characterized by an insidious onset and poor prognosis. We present the case of a 79-year-old Caucasian male who experienced escalating abdominal pain for six weeks and acute abdominal distension. His medical history was significant for hypertension, gastroesophageal reflux disease (GERD), hypercholesterolemia, and prior coronary artery bypass grafting (CABG). The patient had a 30-pack-year smoking history and worked as a plumber and roofer until retirement. We also confirmed with the patient that he has never been diagnosed with asbestosis. He reported no family history of mesothelioma or related conditions. A computed tomography (CT) scan revealed a prior sternotomy, mild pleural calcifications, mild hepatic steatosis, diffuse peritoneal ascites, diffuse omental edema, and pelvic phleboliths. MPM was confirmed through histopathological examination, which revealed atypical mesothelial cells with high nucleus-to-cytoplasm ratios, prominent nucleoli, and irregular nuclear membranes. It also revealed tumor cells positive for p53, calretinin, WT1, and podoplanin (D2-40). This case highlights the importance of considering MPM in the differential diagnosis for patients with ascites and possible asbestos exposure, particularly with respect to occupational hazards, as it is a rare manifestation of the disease.},
}
@article {pmid39481034,
year = {2024},
author = {Gilbert, A and Wieland, R and Zacher, N and Rieger, K and Berry, GJ and Novoa, R},
title = {Metastatic Mesothelioma of the Tunica Vaginalis Presenting as Scrotal and Abdominal Nodules: A Case Report and Review of the Literature.},
journal = {The American Journal of dermatopathology},
volume = {},
number = {},
pages = {},
doi = {10.1097/DAD.0000000000002848},
pmid = {39481034},
issn = {1533-0311},
abstract = {Mesothelioma of the tunica vaginalis testis (MMTVT) is a rare neoplasm comprising <3% of all cases of malignant mesothelioma (MM). MMTVT derives from the tunica vaginalis testis, an outpouching of the mesothelial-lined abdominal peritoneum that detaches from the abdominal cavity after the descent of the testis. Similar to pleural mesothelioma, asbestos exposure is a known risk factor. However, MMTVT has a better prognosis than pleural mesothelioma. Cutaneous metastases from MMTVT are exceedingly rare. Herein, we describe a case of a 67-year-old man with a history of asbestos exposure presenting with scrotal pain and indurated plaques on his lower abdomen and scrotum. Histologic sections showed a sheet-like dermal proliferation comprising epithelioid cells with necrosis and increased mitotic activity. The clinical and histologic differential diagnosis was broad, including metastatic carcinoma, melanoma, sarcoma, germ cell tumor, hematologic malignancy, neuroendocrine carcinoma, and malignant mesothelioma. By immunohistochemistry, the neoplastic cells were positive for WT1, D2-40, and AE1/AE3, with rare positivity for calretinin, consistent with a diagnosis of mesothelioma. Additional immunohistochemical studies provided no support for the other diagnostic considerations listed above. BAP1 showed retained nuclear expression (normal) by immunohistochemistry. A DNA sequencing panel identified copy number losses in CDKN2A, MTAP, CDKN2B, and NF2, which are frequently identified genetic alterations in malignant mesothelioma. Subsequent testicular imaging demonstrated a diffusely thickened scrotal wall with an enlarged left testicle. Overall, this represents a case of malignant mesothelioma presenting with cutaneous metastases to the scrotum and lower abdomen, with clinical and imaging features suggestive of primary MMTVT. The International Mesothelioma Interest Group recommends using at least 2 mesothelial markers, such as calretinin, WT1, CK5/6 or D2-40, and 2 epithelial markers, such as claudin-4, CEA, MOC-31, as well as a broad-spectrum cytokeratin stain (AE1/AE3) as part of an initial immunohistochemical panel. Metastatic mesothelioma should be included in the differential diagnosis of malignant epithelioid dermal tumors with unusual staining patterns.},
}
@article {pmid39474071,
year = {2024},
author = {Behrouzfar, K and Mutsaers, SE and Chin, WL and Patrick, K and Ng, IT and Pixley, FJ and Morahan, G and Lake, RA and Fisher, SA},
title = {Mesothelioma survival prediction based on a six-gene transcriptomic signature.},
journal = {iScience},
volume = {27},
number = {10},
pages = {111011},
pmid = {39474071},
issn = {2589-0042},
abstract = {Mesothelioma is a lethal cancer. Despite promising outcomes associated with immunotherapy, durable responses remain restricted to a minority of patients, highlighting the need for improved strategies that better predict outcome. Here, we described the development of a mesothelioma-specific gene signature that accurately predicts survival. Comprehensive gene expression analysis of asbestos exposed MexTAg Collaborative Cross mouse tumors revealed distinct tumor clusters characterized by epithelial mesenchymal transition/extracellular matrix, or immune infiltrate related gene expression profiles. Weighted gene co-expression network analysis (WGCNA) identified 20 hub genes that drove differential gene expression. Human homologues of these 20 hub genes were refined through univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression analyses to identify a six-gene mesothelioma-specific prognostic signature that accurately predicted patient survival across four independent human mesothelioma datasets. Furthermore, this six-gene signature demonstrated the potential to predict treatment response, thus advancing the management of this challenging malignancy.},
}
@article {pmid39472148,
year = {2024},
author = {Mei, W and Yang, SJ and Zhang, YP},
title = {[Establishment and research progress of early diagnosis system for pleural mesothelioma].},
journal = {Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases},
volume = {42},
number = {10},
pages = {793-800},
doi = {10.3760/cma.j.cn121094-20230915-00060},
pmid = {39472148},
issn = {1001-9391},
support = {202301BA070001-26, 202301BA070001-027//Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities/ ; 81560458, 31601155//National Natural Science Foundation of China/ ; },
mesh = {Humans ; *Mesothelioma/diagnosis ; *Pleural Neoplasms/diagnosis ; *Early Detection of Cancer/methods ; MicroRNAs/blood ; Lung Neoplasms/diagnosis ; Biomarkers, Tumor/blood ; Breath Tests ; Early Diagnosis ; Mesothelioma, Malignant/diagnosis ; },
abstract = {Pleural mesothelioma (PMe) was associated with asbestos exposure.The Diagnosis of PMe is difficult due to the lack of specificity of clinical signs and symptoms, although there are many tools available for early diagnosis of mesothelioma. Most PMe patients are diagnosed at an advanced stage. This article reviews advances in strategies for early diagnosis of mesothelioma, focusing on breath analysis, early diagnosis of pleural effusion cytology in patients with mesothelioma, serum biomarkers and miRNA.},
}
@article {pmid39469233,
year = {2024},
author = {Santos, C and Sacadura-Leite, E and Feijó, S and Dixe, MDA and Astoul, P and Sousa-Uva, A},
title = {Translation, Cultural Adaptation, and Content Validation of a Pleural Mesothelioma Questionnaire to Portuguese Context - A Key Tool for Epidemiological Surveillance.},
journal = {Portuguese journal of public health},
volume = {42},
number = {2},
pages = {101-110},
pmid = {39469233},
issn = {2504-3145},
abstract = {OBJECTIVE: The main objective of this study was to describe the translation, cultural adaptation, and content validation process of the French National Surveillance Programme for Pleural Mesothelioma (FNSPPM) questionnaire for the Portuguese context.<br><br>METHODS: A search was conducted in the PubMed database and Web of Science, in the period from January 1, 1960, to December 31, 2022, to select the questionnaire. Forward and reverse translations, calculation of the content validity index (CVI) by a panel of experts (n = 9), and cognitive interviewing with individuals with at least one exposure to asbestos (n = 10) were performed. Experts rated items on a Likert scale (1-4) based on their relevance. The item-level content validity index (I-CVI), scale-level content validity index based on the average method (S-CVI/Ave), and scale-level content validity index based on the universal agreement method (S-CVI/UA) were calculated.<br><br>RESULTS: The final version of the FNSPPM questionnaire for the Portuguese context resulted from a translation and content validation process. The panel of experts considered the questionnaire relevant, with an I-CVI of up to 0.78 in 68 of 69 of the questions, an S-CVI/Ave of 0.98, and an S-CVI/UA of 0.90. The participants in the cognitive interviews reported an understanding of the questionnaire.<br><br>CONCLUSION: A validated FNSPPM questionnaire for the Portuguese context is now available to study individuals with pleural mesothelioma (PM) and asbestos exposure.},
}
@article {pmid39469260,
year = {2023},
author = {Santos, C and Dixe, MDA and Sacadura-Leite, E and Astoul, P and Sousa-Uva, A},
title = {Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature.},
journal = {Portuguese journal of public health},
volume = {40},
number = {3},
pages = {188-202},
pmid = {39469260},
issn = {2504-3145},
abstract = {BACKGROUND: The relationship between exposure to asbestos and malignant pleural mesothelioma (MPM) is already well established. Nevertheless, much remains to be known about exposure thereto and the incidence and mortality from MPM.<br><br>OBJECTIVE: This systematic review aims to map the relationship between asbestos and MPM by studying the exposure to asbestos and the incidence and mortality of MPM.<br><br>METHODS: A systematic review was conducted relating asbestos and MPM. Exposure to asbestos, incidence, and mortality by MPM was reviewed. PubMed, Web of Science, Cochrane Library, RCAAP, DART-Europe, and the reference lists of included studies were searched, from January 1, 1960, to December 31, 2020. Methodological quality was checked, the risk of bias analysis was performed, a level of evidence grade was assigned, and descriptive data analysis was performed.<br><br>RESULTS: 3,484 unique citations were identified, which included seventeen observational studies that met inclusion criteria with a total of 1,104 patients. Heterogeneity is present between the included studies which range from a case series of 16 retrospective studies and 1 prospective study. Studies were mostly conducted in Europe, particularly in Italy (6), and were published between 1969 and 2020. The mean age of patients is approximately 66 years with a latency period between the first exposure and diagnosis of approximately 42 years. 14 studies present data regarding the occupational context and chrysotile and crocidolite are the most studied types of fibre. The incidence of cases occurred between the interval 1966 and 2014 and in 9 studies the mortality rate was 100% of patients.<br><br>CONCLUSION: There is high evidence to support the relationships between asbestos and MPM. However, the relatively scant information provided by the studies reinforces the need for well-conducted research and implementation of National Mesothelioma Surveillance Centres at a global level.},
}
@article {pmid39447016,
year = {2024},
author = {Stevens, ME and Tuttle, BP and Brew, DW and Paustenbach, DJ},
title = {An evaluation of trends for mesothelioma mortality in American women: Addressing the content of a recent Morbidity and Mortality Weekly Report (MMWR).},
journal = {Toxicology and industrial health},
volume = {},
number = {},
pages = {7482337241293201},
doi = {10.1177/07482337241293201},
pmid = {39447016},
issn = {1477-0393},
abstract = {Mesothelioma is a fatal disease that has historically been associated with exposure to airborne asbestos. Because occupational asbestos exposures dropped dramatically in the late 1960s and early 1970s, far fewer cases of mesothelioma today are due to these fibers but, instead, are usually a result of the aging process or genetic predisposition. In May of 2022, a Morbidity and Mortality Weekly Report (MMWR) was issued by the Centers for Disease Control and Prevention (CDC) regarding malignant mesothelioma incidence in women from 1999 to 2020. While this MMWR alerted citizens to the continued presence of the disease, after reading this article one might have thought that the CDC was suggesting that the disease was increasing in women due to asbestos exposures (which it is not). In the present analysis, we investigate several factors related to the interpretation of epidemiological data for mesothelioma, including the role of asbestos as a risk factor over time. The authors conducted a review of the scientific community's understanding of mesothelioma incidence and asbestos exposures amongst women, as well as an investigation of the methods and references in the MMWR article. Although various articles have recently discussed the incidence of both peritoneal and pleural mesothelioma in women, it is fortunate that the age-adjusted rates for mesothelioma have remained flat (neither increased nor decreased significantly) in women for the past 50 years. Incredibly few women in the U. S. have had appreciable cumulative exposures to any type of asbestos (chrysotile, amosite, or crocidolite) in the workplace or from the ambient environment, especially since about 1965-1970. In this paper, we highlight six factors that should be considered when evaluating the incidence of mesothelioma amongst American women in the current era. Without sufficient consideration of these factors, improper conclusions have been drawn over the past several years.},
}
@article {pmid39445262,
year = {2024},
author = {Paremuzyan, A and Onwubuya, E and Mathews, J},
title = {A Case of Malignant Pleural Mesothelioma With Unknown Asbestos Exposure.},
journal = {Cureus},
volume = {16},
number = {9},
pages = {e69966},
pmid = {39445262},
issn = {2168-8184},
abstract = {Malignant pleural mesothelioma (MPM) is a rare, locally invasive tumor that develops from mesothelial cells lining the lung's pleura. It is mostly associated with prolonged asbestos exposure. The long latency period between asbestos exposure and clinical symptoms makes diagnosing MPM challenging. This report describes a 57-year-old Hispanic female who presented with a persistent nonproductive cough and was ultimately diagnosed with advanced-stage pleural mesothelioma after extensive work-up. It highlights the difficulties in diagnosing MPM in patients without apparent asbestos exposure independent of age or gender.},
}
@article {pmid39441675,
year = {2024},
author = {Suehiro, T and Ahmad, KM and Hoang, NTD and Xu, B and Komatsu, H and Kurachi, K and Nikawa, H and Mine, Y and Matsuki, T and Asano, K and Fujii, M},
title = {Activation of platelet-derived growth factor receptors regulate connective tissue growth factor protein levels via the AKT pathway in malignant mesothelioma cells.},
journal = {Journal of biochemistry},
volume = {},
number = {},
pages = {},
doi = {10.1093/jb/mvae068},
pmid = {39441675},
issn = {1756-2651},
abstract = {The incidence of malignant mesothelioma (MM), a disease linked to refractory asbestos exposure, continues to increase globally, and remains largely resistant to various treatments. Our previous studies have identified a strong correlation between connective tissue growth factor (CTGF) protein expression and MM malignancy, underscoring the importance of understanding CTGF regulation in MM cells. In this study, we demonstrate for the first time that stimulation with platelet-derived growth factor receptor (PDGFR) ligand, PDGF-BB, increases CTGF protein expression levels without affecting CTGF mRNA levels. Inhibition of PDGFR resulted in a reduction of CTGF protein expression, indicating that PDGFR activation is essential in regulating CTGF protein expression in MM cells. PDGF-BB also activated the protein kinase B (AKT) pathway, and inhibition of AKT phosphorylation abolished the PDGFR-induced CTGF protein expression, suggesting that PDGFR acts upstream of CTGF via the AKT pathway. This reinforces the role of CTGF protein as a key regulator of MM malignancy. Additionally, PDGFR activation led to the phosphorylation of mTOR and 4E-BP1, critical regulators of protein synthesis downstream of AKT, suggesting that PDGFR controls CTGF protein expression through the regulation of CTGF mRNA translation.},
}
@article {pmid39439640,
year = {2024},
author = {Guerra, J and Pina, JM and Andrade, V and Cassis, J and Campos Pinheiro, L},
title = {Malignant Mesothelioma of the Tunica Vaginalis: About a Rare Clinical Case.},
journal = {Cureus},
volume = {16},
number = {9},
pages = {e69897},
pmid = {39439640},
issn = {2168-8184},
abstract = {Malignant mesothelioma (MM) of the tunica vaginalis is an exceedingly rare neoplasm, with fewer than 300 cases reported in the medical literature. Due to its rarity, epidemiology, and risk factors are still unclear, and it is unknown whether asbestos or chronic inflammatory conditions play a role in etiology. This case study presents a 70-year-old male patient with MM of the tunica vaginalis, detailing the diagnostic challenges, treatment procedures, and eventual progression to palliative care. The study underscores the importance of accurate diagnosis and the aggressive nature of the disease despite treatment efforts.},
}
@article {pmid39434641,
year = {2024},
author = {Visonà, SD and Pace, MC and Consonni, D and Mensi, C},
title = {Accuracy of the Lombardy Mesothelioma Registry: comparison with the autopsy database of Pavia University (Lombardy Region, Northern Italy).},
journal = {Epidemiologia e prevenzione},
volume = {48},
number = {4-5},
pages = {320-325},
doi = {10.19191/EP24.4-5.A736.096},
pmid = {39434641},
issn = {1120-9763},
mesh = {Humans ; Italy/epidemiology ; *Registries ; *Autopsy ; *Mesothelioma/mortality/pathology/epidemiology ; Male ; *Sensitivity and Specificity ; *Databases, Factual ; Female ; Aged ; Middle Aged ; Incidence ; Asbestos/adverse effects ; Universities ; },
abstract = {OBJECTIVES: to evaluate the accuracy (completeness of case recording and diagnostic quality) of the Lombardy Mesothelioma Registry (Registro Mesoteliomi Lombardia, RML) through a comparison with the autopsy database of Pavia University (years 2000-2016).<br><br>DESIGN: validation study.<br><br>SETTING AND PARTICIPANTS: all mesothelioma records with incidence date between 01.01.2000 and 16.09.2016 were extracted from the RML. They were cross-referenced with deaths from any asbestos-related disease subjected to a forensic autopsy extracted from the archive of the Department of Public Health, Experimental and Forensic Medicine of Pavia University.<br><br>MAIN OUTCOMES MEASURES: using the postmortem diagnosis by Pavia University as the gold standard, RML sensitivity and specificity and their 95% confidence intervals (95%CI) were calculated using the Agresti-Coull formula.<br><br>RESULTS: based on 141 deaths, the RML showed very good accuracy: specificity was 100% (95%CI 87%-100%; 32/32 deaths) and sensitivity 94% (95%CI 87%-97%; 102/109 deaths). The 7 false negative cases either were missed by the RML (N. 4) or had been wrongly classified as non-mesotheliomas (N. 3) because the diagnosis was made or confirmed only postmortem after a forensic autopsy.<br><br>CONCLUSIONS: RML accuracy (completeness and diagnostic quality) was very high. No false positive was found and the few false negatives were due to lack of notification of mesotheliomas diagnosed postmortem to the registry. Forensic pathologists should be made aware that mesothelioma notification to the regional mesothelioma registry is important and compulsory.},
}
@article {pmid39430319,
year = {2024},
author = {Ye, L and Ryu, H and Granadier, D and Nguyen, LT and Simoni, Y and Dick, I and Firth, T and Rouse, E and Chiang, P and Lee, YCG and Robinson, BW and Creaney, J and Newell, EW and Redwood, AJ},
title = {Stem-like exhausted CD8 T cells in pleural effusions predict improved survival in non-small cell lung cancer (NSCLC) and mesothelioma.},
journal = {Translational lung cancer research},
volume = {13},
number = {9},
pages = {2352-2372},
pmid = {39430319},
issn = {2218-6751},
abstract = {BACKGROUND: Anti-tumor CD8 T cells are important for immunity but can become 'exhausted' and hence ineffective. Tumor-infiltrating exhausted CD8[+] T cells include less differentiated stem-like exhausted T (Tex[stem]) cells and terminally exhausted T (Tex[term]) cells. Both subsets have been proposed as prognostic biomarkers in cancer patients. In this study, we retrospectively investigated their prognostic significance in patients with metastatic non-small cell lung cancer (NSCLC) and validated our findings in a mesothelioma cohort.<br><br>METHODS: Pre-treatment malignant pleural effusions (PEs) from 43 NSCLC (41 non-squamous, 2 squamous) patients were analyzed by flow cytometry. The percentages of Tex[stem] and Tex[term] CD8 T cells were correlated with overall survival (OS) after adjusting for clinicopathological variables. Findings were validated using a mesothelioma cohort (n=49). Mass cytometry was performed on 16 pre-treatment PE samples from 5 mesothelioma and 3 NSCLC patients for T-cell phenotyping. Single-cell multi-omics analysis was performed on 4 pre-treatment PE samples from 2 NSCLC patients and 2 mesothelioma patients for analysis of the transcriptomic profiles, surface markers and T cell receptor (TCR) repertoire.<br><br>RESULTS: Higher frequency of Tex[stem] was associated with significantly increased OS [median 9.9 vs. 3.4 months, hazard ratio (HR) 0.36, 95% CI: 0.16-0.79, P=0.01]. The frequency of Tex[term] was not associated with OS. These findings were validated in the mesothelioma cohort (high vs. low Tex[stem], median OS 32.1 vs. 19.8 months, HR 0.31, 95% CI: 0.10-0.96, P=0.04). Detailed single-cell sequencing and mass cytometry profiling revealed that exhausted T cells from NSCLC expressed greater stem-likeness and less inhibitory markers than those from mesothelioma and that Tex[stem] cells also contained 'bystander' virus-specific T cells.<br><br>CONCLUSIONS: This study demonstrates that PE CD8 Tex[stem] cell abundance is associated with better survival outcomes, and thus may be a useful prognostic biomarker.},
}
@article {pmid39410011,
year = {2024},
author = {Stella, GM and Lisini, D and Pedrazzoli, P and Galli, G and Bortolotto, C and Melloni, G and D'Ambrosio, G and Klersy, C and Grosso, A and Paino, F and Tomaselli, S and Saracino, L and Alessandri, G and Pessina, A and Grignani, E and Rosti, V and Corsico, AG and Comoli, P and Agustoni, F},
title = {Phase I Clinical Trial on Pleural Mesothelioma Using Neoadjuvant Local Administration of Paclitaxel-Loaded Mesenchymal Stromal Cells (PACLIMES Trial): Study Rationale and Design.},
journal = {Cancers},
volume = {16},
number = {19},
pages = {},
doi = {10.3390/cancers16193391},
pmid = {39410011},
issn = {2072-6694},
support = {PLAGENCELL//Fondazione Regionale per la Ricerca Biomedica , PLAGENCELL project - A network for cell and gene therapies for devastating diseases (grant to A.G.C. and P.C.)/ ; },
abstract = {Background and rationale. Pleural mesothelioma (PM) is a rare and aggressive neoplasm that originates from the pleural mesothelium and whose onset is mainly linked to exposure to asbestos, which cannot be attacked with truly effective therapies with consequent poor prognosis. The rationale of this study is based on the use of mesenchymal stromal cells (MSCs) as a vehicle for chemotherapy drugs to be injected directly into the pathological site, such as the pleural cavity. Study design. The study involves the use of a conventional chemotherapeutic drug, Paclitaxel (PTX), which is widely used in the treatment of different types of solid tumors, including PM, although some limitations are related to pharmacokinetic aspects. The use of PTX-loaded MSCs to treat PM should provide several potential advantages over the systemically administered drug as reduced toxicity and increased concentration of active drug in the tumor-surrounding context. The PACLIMES trial explores the safety and toxicity of the local administration of Paclimes in chemonaive patients, candidates for pleurectomy. The secondary objective is to find the effective Paclimes dose for subsequent phase II studies and to observe and record the antitumor activity. Future direction. The experimental pre-clinical background and rationale are discussed as well.},
}
@article {pmid39409190,
year = {2024},
author = {Chiec, L and Bruno, DS},
title = {Immunotherapy for Treatment of Pleural Mesothelioma: Current and Emerging Therapeutic Strategies.},
journal = {International journal of molecular sciences},
volume = {25},
number = {19},
pages = {},
doi = {10.3390/ijms251910861},
pmid = {39409190},
issn = {1422-0067},
mesh = {Humans ; *Immunotherapy/methods ; *Pleural Neoplasms/therapy/immunology/pathology ; *Mesothelioma/therapy/immunology/pathology ; Immune Checkpoint Inhibitors/therapeutic use ; Mesothelioma, Malignant/therapy/pathology ; Clinical Trials as Topic ; },
abstract = {Pleural mesothelioma is a rare malignancy associated with asbestos exposure and very poor prognosis, with a 5-year overall survival of 12%. Outcomes may vary according to stage at time of diagnosis and histologic subtype. Most recently, clinical trials utilizing dual checkpoint inhibitor regimens and chemotherapy in combination with immune oncologic agents have demonstrated impactful changes in outcomes. In this article, we review studies that have led to the successful implementation of immunotherapy in clinical practice for the treatment of this disease and highlight ongoing clinical trials exploring the use of different immunotherapy strategies for the treatment of pleural mesothelioma. We also discuss the challenges of immunotherapy-based approaches in the context of mesothelioma and future strategies currently being investigated to overcome them.},
}
@article {pmid39407894,
year = {2024},
author = {Jain, M and Crites, MK and Rich, P and Bajantri, B},
title = {Malignant Pleural Mesothelioma: A Comprehensive Review.},
journal = {Journal of clinical medicine},
volume = {13},
number = {19},
pages = {},
doi = {10.3390/jcm13195837},
pmid = {39407894},
issn = {2077-0383},
abstract = {Mesotheliomas are hyperplastic tumors that envelop the serosal membranes that safeguard the body's external surfaces. Although certain instances may exhibit indolent characteristics, a significant number of tumors demonstrate rapid progression and a poor prognosis. Mesotheliomas are typically categorized as benign or malignant, with malignant mesothelioma being more frequently linked to asbestos exposure. Malignant pleural mesothelioma (MPM) predominantly impacts males and often emerges in the late 50 s or beyond, characterized by a median age of early 70 s among patients exposed to asbestos lasting from 2 to 4 decades. Respiratory exposure to asbestos particles leads to the development of malignant mesothelioma, characterized by recurrent inflammation, disruption of cell division, activation of proto-oncogenes, and generation of free radicals. In pleural mesothelioma, BAP1, CDKN2A, and NF are the most often mutated genes. Accurate diagnosis and assessment usually require the use of chest computed tomography (CT) scans, magnetic resonance imaging (MRI), and positron emission tomography (PET). Radiation therapy, immunotherapy, chemotherapy, and surgery are some of the treatment options that are currently available. This systematic review provides a comprehensive analysis of the latest research, biomarkers, evaluation, and management strategies for malignant pleural mesothelioma.},
}
@article {pmid39400365,
year = {2024},
author = {Arrandale, VH and Berriault, C and Song, C and DeBono, N and Demers, PA},
title = {Surveillance of asbestos related disease among workers enrolled in an exposure registry.},
journal = {American journal of industrial medicine},
volume = {},
number = {},
pages = {},
doi = {10.1002/ajim.23668},
pmid = {39400365},
issn = {1097-0274},
support = {//Ontario Ministry of Labour, Immigration, Training and Skills Development/ ; },
abstract = {INTRODUCTION: Contemporary asbestos exposure occurs during construction, remediation, and maintenance involving asbestos-containing materials (ACM), as compared to the historical exposure scenarios of asbestos mining and milling. The Ontario Asbestos Workers Register (AWR) was established in 1986 to track asbestos exposure among construction workers. This study reports on the risk of asbestos-related diseases (ARD) among workers in the AWR.<br><br>METHODS: AWR registrants were linked probabilistically with administrative health databases (1986-2019) to identify cases of ARD including both cancer and chronic respiratory disease. Follow-up began at AWR enrollment and continued prospectively. Incidence rates were compared to the general population using standardized incidence ratios (SIRs). Associations between ACM exposure and ARD were estimated among AWR registrants using Poisson regression.<br><br>RESULTS: In total, 26,204 (81%) registrants were linked successfully. Common industries of employment were construction (62%), manufacturing (19%) and education (8%). Among men and women mesothelioma (M:SIR 6.83 [95% CI&#x2009;=&#x2009;5.56-8.31]; W:SIR 19.2 [3.86-56.1]) and pulmonary fibrosis (M:SIR 14.1 [12.2-16.2]; W:SIR 9.25 [2.49-23.7]) rates were higher than the general population. Asbestosis risk was elevated among men (M:SIR 11.2 [9.59-13.1]). Workers with longer reported exposures (&#x2265;140&#x2009;h) had increased rates of lung cancer (RR 1.34 [1.10-1.63]), mesothelioma (RR 2.83 [1.75-4.58]), asbestosis (RR 3.07 [2.12-4.43]), chronic obstructive pulmonary disease (RR 1.42 [1.29-1.57]), and pulmonary fibrosis (RR 1.88 [1.35-2.62]).<br><br>CONCLUSION: Exposure to asbestos in construction and building maintenance continues to contribute to ARD incidence. Despite a Canadian ban on asbestos in new products, exposures to existing ACM will persist from construction activities. The AWR offers an opportunity for ongoing surveillance of resulting ARD in Ontario.},
}
@article {pmid39394704,
year = {2024},
author = {Li, R and Yu, WK and Wang, Q and Zhu, LJ and Zhang, FF},
title = {[Expression changes of miRNAs and EMT-related genes in human mesothelial cells induced by long-term exposure to asbestos].},
journal = {Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases},
volume = {42},
number = {9},
pages = {668-672},
doi = {10.3760/cma.j.cn121094-20240112-00014},
pmid = {39394704},
issn = {1001-9391},
support = {LQY18H260001, LGD21C040008//Natural Science Foundation of Zhejiang Province/ ; YS2022012//Special Plan Project of Hangzhou Medical College Institute/ ; },
mesh = {Humans ; *MicroRNAs/genetics/metabolism ; *Epithelial-Mesenchymal Transition/drug effects ; *Asbestos, Serpentine/toxicity ; Epithelial Cells/metabolism/drug effects ; Asbestos/toxicity ; Mesothelioma/genetics/chemically induced ; Cell Line, Tumor ; Cadherins/genetics/metabolism ; Vimentin/metabolism/genetics ; Cell Line ; Pleural Neoplasms/genetics/chemically induced/metabolism ; },
abstract = {Objective: To investigate the effects of long-term exposure to chrysotile and crocidolite on miRNAs and epithelial mesenchymal transformation (EMT) -related gene expression in human pleural mesothelial cells. Methods: In November 2020, fluorescence quantitative polymerase chain reaction (RT-qPCR) was used to detect the expressions of EMT-related genes in human pleural mesothelioma cells (NCl-H2052 cells, NCl-H2452 cells) and human normal mesothelial cells (Met-5A cells). MiRNAs with abnormal expression in human pleural mesothelioma cells were screened out from the previous miRNA chip data of research group, and target genes of differentially expressed miRNAs were predicted using miRWalk database (http: //mirwalk.umm.uni-heidelberg.de). RT-qPCR was used to verify the abnormal expression of EMT-related miRNAs in cell lines. Met-5A cells were treated with 5μg/cm(2) chrysotile and crocidolite respectively for 48 h a time, once a week and a total of 10 times. Chrysotile group, crocidolite group and control group were set up. And the control group was added with the same volume of PBS. The expression changes of EMT-related genes and abnormal expression miRNAs in each group were detected by RT-qPCR. The differences among the groups were compared by one-way ANOVA, and the differences between the control group and the experimental group were compared by dunnet-t test. Results: Compared with Met-5A cells, the expression levels of Vimentin and Twist genes were increased, and the expression level of E-cadherin genes was decreased in NCl-H2052 cells and NCl-H2452 cells (P<0.001). Target genes of miRNAs with abnormal expression in miRNA chip were predicted, and the results showed four abnormally expressed miRNAs associated with EMT and verified the expression of these four miRNAs in the cell lines. Compared with Met-5A cells, the expression level of hsa-miR-155-5p was increased in NCl-H2052 cells and NCl-H2452 cells, the expression levels of hsa-miR-34b-5p, hsa-miR-34c-5p and hsa-miR-28-5p were decreased in NCl-H2052 cells and NCl-H2452 cells (P<0.001), which was consistent with the results of chip analysis. After exposure of Met-5A cells, it was found that compared with the control group, the expression levels of Vimentin and Twist genes, hsa-miR-155-5p, hsa-miR-34b-5p and hsa-miR-34c-5p in the crocidolite group were increased, while the expression level of E-cadherin gene was decreased (P<0.05). Compared with the control group, the expression levels of Vimentin, Twist and E-cadherin genes in chrysotile group were increased, while the expression levels of hsa-miR-34b-5p, hsa-miR-34c-5p and hsa-miR-28-5p were decreased (P<0.05) . Conclusion: Long-term exposure to chrysotile and crocidolite could cause Met-5A cells to produce miRNAs and EMT-related gene expression changes similar to mesothelioma cells.},
}
@article {pmid39377019,
year = {2024},
author = {Rezvani, A and Shahriarirad, R and Jahanshahi, S and Fouladi, D and Tavallali, M and Ziaian, B and Fallahi, MJ},
title = {The aftermath of asbestos prohibition in industry and its association with malignant mesothelioma in the south of Iran: An enduring predicament yet to be resolved.},
journal = {Health science reports},
volume = {7},
number = {10},
pages = {e70117},
pmid = {39377019},
issn = {2398-8835},
abstract = {PURPOSE: Malignant Mesothelioma (MM) is a rare malignancy of the serosa membranes with a high mortality rate and long latent period. The relationship between a group of mineral fibers known as asbestos and mesothelioma is now well accepted in which people can be exposed to these fibers by various means during their lifetime and has been its usage has banned in many countries, such as Iran, which announced its gradual elimination from 1999 over a period of 7 years by using safe substitutes. However, the mineral particles are able to sustain itself in the environment, air, water, and soil and on the other hand, symptoms may take up to half a century to develop in exposed individuals. Also, there remains a shortage of comprehensive investigation on the effects of asbestos exposure within the familial context (household or domestic exposure) or on individuals residing in proximity to asbestos mines or factories (environmental exposure). Based on the high number of MM cases in Iran, and also our hypothesis that residuals of asbestos in the environment and petroleum products may be the etiological factor for MM, we conducted this study to evaluate the clinic epidemiological features of MM in the south of Iran its relation to possible asbestos exposure.<br><br>METHODS: In this study, we analyzed the demographic features and occupations of confirmed cases of MM in Shiraz, southern Iran along with the follow-up of the patients' disease from 2008 to 2018, while also comparing the features of our patients with a control group compromising of 105 non-MM patients.<br><br>RESULTS: Among the 35 confirmed cases of MM, with an average age of 61 years, 9 (25.7%) were female, and 26 (74.3%) were male. During our assessment, 12 patients had already died, with a mean time of 11.26 months post-diagnosis. Our findings revealed a higher prevalence of MM among housekeepers and employees of oil companies. In comparison to the control group, individuals with occupational exposure and those residing near refinery locations were at a heightened risk of developing MM. However, based on regression analysis, only occupations associated with refineries exhibited a significant correlation with MM (p&#x2009;=&#x2009;0.028; OR: 14.602; 95% CI: 1.328-160.499).<br><br>CONCLUSION: Both occupational and para-occupational exposure demonstrated a significant correlation with MM, whereas our regression analysis did not affirm geographical and environmental factors as contributors to MM. Despite the industry's prohibition of direct asbestos usage, the persistent existence of asbestos particles in the environment for decades, coupled with the long latency period of MM, warrants further investigation. Health authorities and policymakers should recognize this potential hazard, prompting an enhancement of early detection within at-risk groups.},
}
@article {pmid39371847,
year = {2024},
author = {R, PD and Grace Priyadarshini, S and P, J},
title = {Malignant Mesothelioma: Overcoming Diagnostic Hurdles.},
journal = {Cureus},
volume = {16},
number = {9},
pages = {e68718},
pmid = {39371847},
issn = {2168-8184},
abstract = {Malignant pleural mesothelioma, an aggressive neoplasm frequently linked to asbestos exposure, is often detected at an advanced stage. This report details the case of a 58-year-old mason who presented with left-sided chest pain, and shortness of breath, accompanied by weight loss for a month. A positron emission tomography (PET) scan revealed increased uptake along the pleural surface, as well as in several mediastinal lymph nodes and the left supraclavicular lymph node. Thoracoscopy revealed the presence of multiple nodules on the costal pleura. Despite repeated negative results from pleural effusion cytology, cell block analysis, and pleural biopsies, the diagnosis of malignant mesothelioma (MM) was ultimately established through an ultrasound-guided (USG) biopsy of the left supraclavicular lymph node, with immunohistochemical confirmation using calretinin.},
}
@article {pmid39337157,
year = {2024},
author = {Porzio, A and Feola, A and Salzillo, C and Corbi, G and Campobasso, CP},
title = {Colorectal Cancer and Asbestos Exposure: A Women's Health Perspective.},
journal = {Healthcare (Basel, Switzerland)},
volume = {12},
number = {18},
pages = {},
pmid = {39337157},
issn = {2227-9032},
abstract = {BACKGROUND: Colorectal cancer (CRC) is considered a "man's disease". However, emerging data show that females may have a higher prevalence of certain risk factors. A potential causal role of asbestos in CRC carcinogenesis has been suggested. This relationship is controversial, and only a few studies have focused on exposed female populations. The aim of this study was to review the scientific literature related to asbestos-related CRC incidence and mortality rates in female populations to address gender bias in the existing research.<br><br>METHODS: A systematic review was performed following PRISMA statement.<br><br>RESULTS: Fourteen studies reporting 92 cases in total were included. Most women were aged 50 years or older and were employed in occupational activities with high asbestos exposure (steel, textile, and asbestos-cement industry) for at least 10 years. In one single case, household asbestos exposure was reported. The colon was the primary location of the tumor in 47 out of 92 cases. Three women were also affected by synchronous or metachronous peritoneal mesotheliomas.<br><br>CONCLUSIONS: This study revealed a general methodological "gender bias" in scientific research. A significantly higher representation of women in clinical studies is needed to clarify the link between asbestos exposure and the development of colorectal cancer.},
}
@article {pmid39329996,
year = {2024},
author = {Roca, E and Aujayeb, A and Astoul, P},
title = {Diagnosis of Pleural Mesothelioma: Is Everything Solved at the Present Time?.},
journal = {Current oncology (Toronto, Ont.)},
volume = {31},
number = {9},
pages = {4968-4983},
pmid = {39329996},
issn = {1718-7729},
mesh = {Humans ; *Pleural Neoplasms/diagnosis/therapy ; *Mesothelioma, Malignant/diagnosis/therapy/pathology ; Mesothelioma/diagnosis/therapy ; Lung Neoplasms/diagnosis/therapy ; Biopsy/methods ; Thoracic Surgery, Video-Assisted/methods ; },
abstract = {Ranked high in worldwide growing health issues, pleural diseases affect approximately one million people globally per year and are often correlated with a poor prognosis. Among these pleural diseases, malignant pleural mesothelioma (PM), a neoplastic disease mainly due to asbestos exposure, still remains a diagnostic challenge. Timely diagnosis is imperative to define the most suitable therapeutic approach for the patient, but the choice of diagnostic modalities depends on operator experience and local facilities while bearing in mind the yield of each diagnostic procedure. Since the analysis of pleural fluid cytology is not sufficient in differentiating historical features in PM, histopathological and morphological features obtained via tissue biopsies are fundamental. The quality of biopsy samples is crucial and often requires highly qualified expertise. Since adequate tissue biopsy is essential, medical or video-assisted thoracoscopy (MT or VATS) is proposed as the most suitable approach, with the former being a physician-led procedure. Indeed, MT is the diagnostic gold standard for malignant pleural pathologies. Moreover, this medical or surgical approach can allow diagnostic and therapeutic procedures: it provides the possibility of video-assisted biopsies, the drainage of high volumes of pleural fluid and the administration of sterile calibrated talcum powder under visual control in order to achieve pleurodesis, placement of indwelling pleural catheters if required and in a near future potential intrapleural therapy. In this context, dedicated diagnostic pathways remain a crucial need, especially to quickly and properly diagnose PM. Lastly, the interdisciplinary approach and multidisciplinary collaboration should always be implemented in order to direct the patient to the best customised diagnostic and therapeutic pathway. At the present time, the diagnosis of PM remains an unsolved problem despite MDT (multidisciplinary team) meetings, mainly because of the lack of standardised diagnostic work-up. This review aims to provide an overview of diagnostic procedures in order to propose a clear strategy.},
}
@article {pmid39316223,
year = {2024},
author = {Pacella, A and Ballirano, P and Di Carlo, MC and Altieri, A and Paccapelo, M and Skogby, H and Campopiano, A and Bruno, MR and Croce, A and Piersante, C and Apollaro, C and Malvasi, G and Bruni, BM and Bloise, A},
title = {Geological and mineralogical characterization of fibrous tremolite from Iacolinei quarry (Basilicata, Italy).},
journal = {Environmental geochemistry and health},
volume = {46},
number = {11},
pages = {429},
pmid = {39316223},
issn = {1573-2983},
support = {B87G23000090005//National Institute for Insurance against Accidents at Work (INAIL) - BRIC 2022 project/ ; },
mesh = {Italy ; *Asbestos, Amphibole/analysis ; X-Ray Diffraction ; Geologic Sediments/chemistry ; Environmental Monitoring ; },
abstract = {Naturally Occurring Asbestos (NOA) has drawn the attention worldwide when investigation revealed an increased incidence of malignant mesothelioma in population living near NOA sites. In Basilicata region (South Italy), population living in the villages of Castelluccio Superiore and Inferiore, Lauria, Latronico, Episcopia, San Severino Lucano, and Francavilla in Sinni may be considered at high risk of asbestos exposure because these villages are either surrounded by or built on NOA-rich ophiolitic outcrops. In this work we investigated an asbestos tremolite sample coming from the ophiolitic rocks outcropping in the quarry of Iacolinei, widely used in the past to extract aggregates for various applications. A detailed mineralogical characterization has been attained by using a multi-analytical approach (EMPA, SEM-EDS, TEM-EDS, Mössbauer, µ-Raman, X-ray powder diffraction, and thermal analysis). Morphological investigation highlighted that the sample is composed of long fibers (> 5 µm) with a significant fraction (ca. 55%) having width below 0.25 µm, considered the most biologically active fibers. Moreover, the crystal chemical characterization showed that Fe occurs at the octahedral sites of the tremolite structure. It should be noted that Fe plays a primary role in the toxicity of asbestos. Based on these results, the investigated asbestos tremolite may be considered a potent mesothelial carcinogen, requiring therefore special attention for public health protection purposes. Investigations using sentinel animals to assess the diffusion of the tremolite fibers into the environment from the serpentinite rocks and soils of Iacolinei quarry are in progress.},
}
@article {pmid39312698,
year = {2024},
author = {Khosla, D and Singh, PK and Chhabria, BA and Kataria, V and Singh, N and Kapoor, R},
title = {Malignant pleural mesothelioma: The disdained member of thoracic oncology!.},
journal = {World journal of experimental medicine},
volume = {14},
number = {3},
pages = {91739},
pmid = {39312698},
issn = {2220-315X},
abstract = {Pleural mesothelioma is a very aggressive malignancy that arises from the pleural mesothelial cell lining and is linked strongly to prior asbestos exposure. The ban on asbestos has helped to lower the incidence, but in developing countries like India, it is expected to rise. It has an extended latency period usually progressing over decades and presents with nonspecific symptoms. It has a median survival ranging between 10-22 months. The diagnosis of malignant pleural mesothelioma is challenging and is done using computed tomography (CT), magnetic resonance imaging, or positron emission tomography-CT, with the last two predicting the resectability of the tumor better than CT alone. A pleural biopsy along with an array of immunohistochemical markers, such as p16, BRCA1 associated protein 1, and claudin-4, are required for a definitive diagnosis. Several genetic alterations have prognostic significance as well. The current histological subtype identification is indispensable for decision making because of the new therapeutic avenues being explored. The combination of nivolumab and ipilimumab-based immunotherapy outperformed platinum and pemetrexed-based chemotherapy in terms of survival benefit and improved quality of life especially for non-epithelioid subtypes. However, the latter continues to be a robust treatment option for patients with the epithelioid subtype. Surgery is recommended for resectable cases with radiotherapy being indicated in neoadjuvant, adjuvant, and palliative settings along with systemic treatment. This review article provides an overview of epidemiology, etiology, clinical manifestations, diagnostic approaches (including immunohistochemical and genetic markers), staging, and multidisciplinary approaches to current treatment for malignant pleural mesothelioma using surgery, chemotherapy, immunotherapy, and radiotherapy. It also sheds light on some recent studies (EMPHACIS, CALGB30901, Checkmate-743, etc.) that have led to significant developments in recent years with clinically meaningful results.},
}
@article {pmid39290927,
year = {2024},
author = {Reddy, S and M G, K and Gattu, R and P, A and Kuthadi, M},
title = {Challenging the Norm: Occurrence of Synchronous Pleural and Peritoneal Mesothelioma in a Female Patient.},
journal = {Cureus},
volume = {16},
number = {8},
pages = {e67118},
pmid = {39290927},
issn = {2168-8184},
abstract = {Here, we present a unique case involving a female patient in her 40s with synchronous malignant pleural and peritoneal mesothelioma, despite lacking a history of asbestos exposure. The patient's initial symptoms included dyspnoea, chest pain, cough, fever, appetite loss, and weight loss over a month. Clinical evaluation led to the identification of right-sided pleural effusion, prompting consideration of differential diagnoses, such as tubercular or malignant pleural effusion. A thoracoscopy-guided biopsy, followed by histopathological examination and immunohistochemical staining, confirmed the diagnosis of mesothelioma. Chemotherapy was initiated as part of the treatment plan. The prognosis for this condition is generally bad; however, unusual cases of extended survival have been documented. The complexities of our case underscore the critical necessity for a thorough and aggressive evaluation of pleural effusion cases to unveil rare underlying causes, such as mesothelioma.},
}
@article {pmid39281715,
year = {2024},
author = {Huang, Q and Chen, Y and Lian, L and Lei, Q and Chen, J and Wu, L and Hemminki, K and Ji, J and Chen, T},
title = {Burden of malignant mesothelioma in China during 1990-2019 and the projections through 2029.},
journal = {Journal of the National Cancer Center},
volume = {4},
number = {3},
pages = {214-222},
pmid = {39281715},
issn = {2667-0054},
abstract = {OBJECTIVE: To provide the most up-to-date data on the burden of malignant mesothelioma (MM) and the projections through 2029 in China.<br><br>METHODS: Data on patients diagnosed with MM from China during 1990-2019 were obtained from the Global Burden of Disease (GBD) 2019 database, including annual cases and deaths data and age-standardized rates of incidence, mortality, and disability-adjusted life-years (DALYs) associated with MM among different age groups. Temporal trends during 1990-2019 were analyzed by the Joinpoint regression models using 95% confidence interval (CI), while the projections through 2029 were calculated by the Bayesian age-period-cohort model. Data on the production and consumption of asbestos in China were obtained from the United States Geological Survey on Mineral Commodity Summaries during 1996-2023.<br><br>RESULTS: We observed a significant elevation in incident new cases and deaths over the last 3 decades, increasing from 1193 in 1990 to 2815 in 2019 for incident cases and from 1134 in 1990 to 2773 in 2019 for death cases. We found a roughly 6% increase in the proportion of incident cases for those aged >70 years (30% in 2019 versus 24% in 1990), while for the proportion of deaths similar elevation for those aged >70 years was found. Additionally, men had significantly higher DALYs due to MM across age groups compared with women. Asbestos consumption in China dramatically dropped since 2012 and reached the bottom in 2017 with 230 kilotons. By 2029, the projected age-standardized rate for incidence and mortality is expected to reach 1.2 per million for both.<br><br>CONCLUSION: We found, for the first time using GBD data on the Chinese population, that the burden of MM has been significantly increasing in China over the last three decades and will continue to increase in the upcoming decade, suggesting an urgent need for a complete ban on chrysotile asbestos in China.},
}
@article {pmid39269499,
year = {2024},
author = {Sheema, AN and Naiki-Ito, A and Kakehashi, A and Ahmed, OHM and Alexander, DB and Alexander, WT and Numano, T and Kato, H and Goto, Y and Takase, H and Hirose, A and Wakahara, T and Miyazawa, K and Takahashi, S and Tsuda, H},
title = {Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long-term study after 2-week intra-tracheal intrapulmonary administration.},
journal = {Archives of toxicology},
volume = {},
number = {},
pages = {},
pmid = {39269499},
issn = {1432-0738},
support = {JPMH20316858//Ministry of Health, Labour and Welfare/ ; JPMH16769893//Ministry of Health, Labour and Welfare/ ; },
abstract = {Fullerene whiskers (FLW)s are thin rod-like structures composed of C60 and C70 fullerene (FL). The shape of FLWs suggests potential toxic effects including carcinogenicity to the lung and pleura, similar to effects elicited by asbestos and multi-walled carbon nanotubes (MWCNT)s. However, no long-term carcinogenic studies of FL or FLW have been conducted. In the present study we investigated the pulmonary and pleural carcinogenicity of FL and FLW. Twelve-week-old male F344 rats were administered 0.25 or 0.5 mg FL, FLW, MWCNT-7, and MWCNT-N by intra-tracheal intra-pulmonary spraying (TIPS). Acute lung lesions and carcinogenicity were analyzed at 1 and 104 weeks after 8 doses/15 days TIPS administration. At week 1, FLW, MWCNT-7, and MWCNT-N significantly increased alveolar macrophage infiltration. Expression of Ccl2 and Ccl3, reactive oxygen species production, and cell proliferation were significantly increased by administration of MWCNT-7 and MWCNT-N but not FL or FLW. At week 104, the incidence of bronchiolo-alveolar adenoma plus adenocarcinoma was significantly increased in the MWCNT-7 and MWCNT-N groups, and the incidence of mesothelioma was significantly increased in the MWCNT-7 group. No significant induction of pulmonary or pleural tumorigenesis was observed in the FL or FLW groups. The number of 8-OHdG-positive cells in the alveolar epithelium was significantly increased in the MWCNT-7 and MWCNT-N groups but not in the FL or FLW groups. FL and FLW did not exert pulmonary or pleural carcinogenicity in our study. In addition, oxidative DNA damage was implicated in MWCNT-induced lung carcinogenesis, suggesting that it may be a useful initial marker of carcinogenicity.},
}
@article {pmid39265763,
year = {2024},
author = {Feng, L and Li, T and Xu, B and Huang, J and Xia, H and Jiang, Z and Chen, J and Pan, S and Zhang, X and Jiang, H and Lou, J},
title = {Integrated DNA methylation analysis of peripheral blood from asbestos exposed populations and patients with malignant mesothelioma reveals novel methylation driver genes of diagnostic and prognostic relevance.},
journal = {Environmental pollution (Barking, Essex : 1987)},
volume = {362},
number = {},
pages = {124928},
doi = {10.1016/j.envpol.2024.124928},
pmid = {39265763},
issn = {1873-6424},
abstract = {Effective biomarkers are paramount importance for the early detection and prognosis prediction of malignant mesothelioma (MM) which mainly caused by asbestos exposure, and DNA methylation has been demonstrated to be a potentially powerful diagnostic tool. To elucidate the relationship between asbestos exposure and alterations in DNA methylation patterns, as well as the potential diagnostic and prognostic value of differentially methylated regions and CpG sites (DMRs/DMCs) in the progression of MM. The current study employed reduced representation bisulfite sequencing (RRBS) to examine the genome-wide DNA methylation profiles in the peripheral blood of individuals exposed to asbestos and those diagnosed with MM, in comparison to the controls, and DMRs/DMCs were subsequently validated by targeted bisulfite sequencing (TBS). Our results suggested that there were 12 DMRs/DMCs exhibiting a consistent change trend of DNA methylation in both RRBS and TBS results. Significant correlations were observed between DNA methylation levels of DMRs/DMCs and the duration of occupational asbestos exposure. The evaluation of the receiver operating characteristic (ROC) curve suggested that the DNA methylation status of FHIT, CCR12P and CDH15 may serve as diagnosis indicator in distinguishing MM patients from healthy controls and those exposed to asbestos. Our findings offer a foundation for the role of DNA methylation in the development of MM induced by asbestos exposure. The potential significance of FHIT, CCR12P and CDH15 DNA methylation alterations in the pathogenesis and advancement of MM disease suggests their potential as diagnostic and prognostic biomarkers.},
}
@article {pmid39258522,
year = {2024},
author = {Kinsman, N and Del Monaco, A and Dimitriadis, C and Xie, S and Benke, G and Sim, MR and Walker-Bone, K},
title = {Bauxite mine and alumina refinery workers: mortality and cancer risk.},
journal = {Occupational medicine (Oxford, England)},
volume = {74},
number = {7},
pages = {508-513},
pmid = {39258522},
issn = {1471-8405},
support = {//Alcoa of Australia Ltd/ ; },
mesh = {Humans ; Male ; Female ; *Occupational Exposure/adverse effects ; *Aluminum Oxide/adverse effects ; *Occupational Diseases/mortality/epidemiology ; Australia/epidemiology ; *Mining/statistics &amp; numerical data ; Middle Aged ; *Neoplasms/mortality/epidemiology ; Adult ; Incidence ; Risk Factors ; Mesothelioma/mortality/epidemiology ; Aged ; Melanoma/mortality/epidemiology ; Metallurgy ; Prostatic Neoplasms/mortality/epidemiology ; },
abstract = {BACKGROUND: Aluminium industry workers are at risk of long-term health consequences.<br><br>AIMS: To investigate mortality and cancer incidence in bauxite mine and alumina refinery workers.<br><br>METHODS: A pre-existing cohort of workers was re-linked with the Australian National Death Index, and the Australian Cancer Database to provide additional death (7 years) and cancer (9 years) data. Standardized mortality ratios (SMRs) and standardized incidence rates (SIRs) were estimated by job category, duration of employment and time since first employment.<br><br>RESULTS: Linkage was performed for 6935 (6207 male) workers. Compared with the general population, there was a reduced or similar risk of death for mine/refinery workers for all causes except mesothelioma which was increased amongst male production workers [SMR 2.42, 95% CI 1.11-4.60]. Mesothelioma incidence was also increased amongst males [SIR 2.50, 95% CI 1.60-3.71]. Male office workers had a greater incidence of prostate cancer [SIR 1.30, 95% CI 1.06-1.57] and thyroid cancer [SIR 3.47, 95% CI 1.66-6.38]. Melanoma incidence was increased in female office workers [SIR 2.27, 95% CI 1.36-3.54]. Lip cancer incidence was increased in male maintenance/production workers [SIR 2.04, 95% CI 1.02-3.65]. Overall cancer incidence was otherwise similar to the general Australian population.<br><br>CONCLUSIONS: Overall risk of death and incidence of cancer for bauxite mine and alumina refinery workers was similar to the general population. Incidence and risk of death from mesothelioma were higher, likely due to historic asbestos exposure in this and other industries. The increased risk of melanoma, lip, prostate and thyroid cancers requires further investigation.},
}
@article {pmid39237806,
year = {2024},
author = {Duraffour, F and Ramos-Bonilla, JP and Lysaniuk, B},
title = {Use of agent-based modeling to analyze potential non-occupational exposures to asbestos of the general population of Sibaté (Colombia).},
journal = {Environmental monitoring and assessment},
volume = {196},
number = {10},
pages = {900},
pmid = {39237806},
issn = {1573-2959},
support = {ANR-18-CE03-0001-01//Agence Nationale de la Recherche/ ; ANR-18-CE03-0001-01//Agence Nationale de la Recherche/ ; ANR-18-CE03-0001-01//Agence Nationale de la Recherche/ ; },
mesh = {*Asbestos/analysis ; Humans ; *Environmental Exposure/statistics &amp; numerical data ; Environmental Monitoring/methods ; Mesothelioma/epidemiology/chemically induced ; },
abstract = {Previous studies conducted in the municipality of Sibaté (Colombia) have revealed alarming findings regarding asbestos exposure in the region, as it is the site of the country's first mesothelioma cluster. Non-occupational asbestos exposure events were identified in this population, and the young age of the mesothelioma cases at the time of diagnosis suggests that asbestos exposure occurred during their childhood. The creation of landfilled zones in the 1980s and 1990s, utilizing friable asbestos among other disposed materials, may have been a significant asbestos exposure event contributing to the elevated number of mesothelioma cases. The objective of this study was to model various historical exposure scenarios related to the creation and interaction of the population with asbestos-contaminated landfilled zones, in light of the absence of asbestos monitoring in the region. The models utilized a multi-agent simulation process, focusing on a 10-year period (1986-1995). Various relevant variables were incorporated into the modeling process, including, for example, the number of children playing in the landfilled zones and the percentage of children carrying asbestos fibers on their clothes to their homes. A range of values for input data for the models were utilized, spanning from very conservative numbers to exposure-promoting values. The average number of exposed individuals estimated over 750 simulation runs, considering all scenarios, was 571, with a range between 31 and 3800 exposed individuals. The use of multi-agent simulation models can assist the understanding of past asbestos exposure events, especially when there is a lack of environmental surveillance data.},
}
@article {pmid39204360,
year = {2024},
author = {Favaron, C and Gaiaschi, L and Casali, C and De Luca, F and Gola, F and Cavallo, M and Ramundo, V and Aldieri, E and Milanesi, G and Visonà, SD and Ravera, M and Bottone, MG},
title = {Unraveling Novel Strategies in Mesothelioma Treatments Using a Newly Synthetized Platinum(IV) Compound.},
journal = {Pharmaceutics},
volume = {16},
number = {8},
pages = {},
pmid = {39204360},
issn = {1999-4923},
support = {FRG Fondo ricerca e Giovani Maria Grazia Bottone//University of Pavia: Fondi Ricerca Giovani (FRG 2021)./ ; },
abstract = {Malignant mesothelioma is a rare tumor associated with asbestos exposure. Mesothelioma carcinogenesis is related to enhanced reactive oxygen species (ROS) production and iron overload. Despite the recent advances in biomedical sciences, to date the only available treatments include surgery in a small fraction of patients and platinum-based chemotherapy in combination with pemetrexed. In this view, the purpose of this study was to evaluate the therapeutic potential of the newly synthetized platinum prodrug Pt(IV)Ac-POA compared to cisplatin (CDDP) on human biphasic mesothelioma cell line MSTO-211H using different complementary techniques, such as flow-cytometry, transmission electron microscopy (TEM), and immunocytochemistry. Healthy mesothelial cell lines Met-5A were also employed to assess the cytotoxicity of the above-mentioned compounds. Our in vitro results showed that Pt(IV)Ac-POA significantly interfere with iron metabolisms and more importantly is able to trigger cell death, through different pathways, including ferroptosis, necroptosis, and apoptosis, in neoplastic cells. On the other hand, CDDP triggers mainly apoptotic and necrotic cell death. In conclusion, Pt(IV)Ac-POA may represent a new promising pharmacological agent in the treatment of malignant mesothelioma.},
}
@article {pmid39189372,
year = {2024},
author = {Giacomino, F and Marinelli, F and Bisceglia, I and Cacchi, M and Storchi, C and Pinto, C and Mangone, L and Romanelli, A and Morabito, F},
title = {Trends in Asbestos Exposure and Malignant Mesothelioma Incidence in Emilia-Romagna Italy: A Retrospective Study 1996-2023.},
journal = {La Medicina del lavoro},
volume = {115},
number = {4},
pages = {e2024028},
pmid = {39189372},
issn = {0025-7818},
mesh = {Humans ; Italy/epidemiology ; Male ; Retrospective Studies ; Female ; *Asbestos/adverse effects ; Aged ; *Mesothelioma, Malignant/epidemiology ; Incidence ; *Occupational Exposure/statistics &amp; numerical data/adverse effects ; Middle Aged ; *Lung Neoplasms/epidemiology/etiology ; *Mesothelioma/epidemiology/etiology ; Environmental Exposure/adverse effects/statistics &amp; numerical data ; Adult ; Aged, 80 and over ; Occupational Diseases/epidemiology ; },
abstract = {Malignant mesothelioma (MM) is a rare but lethal cancer strongly associated with asbestos exposure. This retrospective study examines trends in asbestos exposure in Emilia-Romagna, Northern Italy. Between 1996 and 2023, 3,513 cases of MM were recorded, predominantly in males (72%) and in older than 65 years (79%). Occupational exposure accounted for 82% of cases, with a significant increase observed over time from 71% to 88% in the most recent period. A greater definition of professional exposure indicates that certain exposure has gone from 49% in the first period to 62% and 58% in the last two periods; probable exposure showed a decrease from 21% to 16% while possible exposure decreased from 16% to 13%. Familiar exposure remained relatively constant at around 8%, environmental exposure showed a slight decrease from 4% to 2%, while non-occupational exposure remained stable at 2%. Among patients with exclusively occupational exposure (1,826 cases), 87% were male and aged between 65 and 75 years (36%) and 75+ (41%). The exposure rates for the province of residence see the province of Reggio Emilia with the highest occupational exposure rate (2.5 x 100,000 residents), followed by Ravenna (2.3 x 100,000 residents) and Parma and Piacenza which have similar exposure rates with 2.2 x 100,000 residents. Professional sectors such as construction, railway maintenance and metalworking are identified as high-risk industries. Despite efforts to mitigate exposure, non-occupational and environmental exposures persist. The study highlights the importance of continuous surveillance and exposure monitoring to guide effective interventions and legal recognition of MM.},
}
@article {pmid39181447,
year = {2024},
author = {Kindler, HL and Rosenthal, A and Giroux, DJ and Nowak, AK and Billè, A and Gill, RR and Pass, H and Rice, D and Ripley, RT and Wolf, A and Blyth, KG and Cedres, S and Rusch, V and , },
title = {The International Association for the Study of Lung Cancer Mesothelioma Staging Project: Proposals for the M Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Pleural Mesothelioma.},
journal = {Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
volume = {},
number = {},
pages = {},
doi = {10.1016/j.jtho.2024.08.022},
pmid = {39181447},
issn = {1556-1380},
abstract = {INTRODUCTION: The International Association for the Study of Lung Cancer developed a global multicenter database to propose evidence-based revisions for the ninth edition of the TNM classification of pleural mesothelioma (PM). This study analyzes the M category to validate eighth edition M category recommendations.<br><br>METHODS: Cases were submitted electronically or by transfer of existing institutional databases for patients with histologically or cytologically confirmed PM. The presence and number of metastases (single versus multiple) in each of eight organ systems were reported for patients with M1 disease at diagnosis. Overall survival (OS) was calculated by the Kaplan-Meier method. Differences in OS were assessed by log-rank test.<br><br>RESULTS: Of 7338 submitted cases, 3598 were eligible and 3221 had sufficient data for clinical staging; 228 cases (7%) were M1. Median overall estimated survival was inferior for M1 compared with M0 patients: 10.5 months versus 21.5 months, respectively (p < 0.0001); estimated 1-year survival was 46% versus 71%, respectively. OS differences between M categories were preserved within histologic subgroups. Among 158 patients with organ-specific documentation of M1 disease, there was no statistically significant difference in OS between those with intrathoracic versus more distant metastatic disease (14.4 mo versus 10.9 mo, p&#xa0;= 0.64). No significant survival difference was detected between patients with metastatic disease in a single-organ system versus multiple-organ systems (12.6 mo versus 8.8 mo, p&#xa0;= 0.45).<br><br>CONCLUSIONS: This evidence-based analysis of the M category for PM conforms with the eighth edition M descriptors. No changes are proposed in the ninth edition of the mesothelioma M category.},
}
@article {pmid39168966,
year = {2024},
author = {Zhang, M and Bzura, A and Baitei, EY and Zhou, Z and Spicer, JB and Poile, C and Rogel, J and Branson, A and King, A and Barber, S and Kamata, T and Dzialo, J and Harber, J and Greystoke, A and Nusrat, N and Faulkner, D and Sun, Q and Nolan, L and Hahne, JC and Scotland, M and Walter, H and Darlison, L and Morgan, B and Bajaj, A and Brookes, C and Hollox, EJ and Lubawska, D and Jama, M and Griffiths, G and Nakas, A and Kutywayo, K and Luo, JL and Klampatsa, A and Cooper, A and Halder, K and Wells-Jordan, P and Zhou, H and Dudbridge, F and Thomas, A and Richards, CJ and Pritchard, C and Yang, H and Barer, M and Fennell, DA},
title = {A gut microbiota rheostat forecasts responsiveness to PD-L1 and VEGF blockade in mesothelioma.},
journal = {Nature communications},
volume = {15},
number = {1},
pages = {7187},
pmid = {39168966},
issn = {2041-1723},
support = {C10604/A25151//Cancer Research UK (CRUK)/ ; },
mesh = {Humans ; *Gastrointestinal Microbiome/drug effects ; *Bevacizumab/therapeutic use/pharmacology ; Male ; *B7-H1 Antigen/metabolism/antagonists &amp; inhibitors ; *Antibodies, Monoclonal, Humanized/therapeutic use ; Female ; *Immune Checkpoint Inhibitors/therapeutic use/pharmacology ; Middle Aged ; Aged ; Mesothelioma, Malignant/drug therapy ; Vascular Endothelial Growth Factor A/metabolism ; Mesothelioma/immunology/drug therapy/microbiology/pathology ; Tumor Microenvironment/immunology ; Lung Neoplasms/drug therapy/immunology/pathology/genetics/microbiology ; Treatment Outcome ; },
abstract = {Malignant mesothelioma is a rare tumour caused by asbestos exposure that originates mainly from the pleural lining or the peritoneum. Treatment options are limited, and the prognosis is dismal. Although immune checkpoint blockade (ICB) can improve survival outcomes, the determinants of responsiveness remain elusive. Here, we report the outcomes of a multi-centre phase II clinical trial (MiST4, NCT03654833) evaluating atezolizumab and bevacizumab (AtzBev) in patients with relapsed mesothelioma. We also use tumour tissue and gut microbiome sequencing, as well as tumour spatial immunophenotyping to identify factors associated with treatment response. MIST4 met its primary endpoint with 50% 12-week disease control, and the treatment was tolerable. Aneuploidy, notably uniparental disomy (UPD), homologous recombination deficiency (HRD), epithelial-mesenchymal transition and inflammation with CD68[+] monocytes were identified as tumour-intrinsic resistance factors. The log-ratio of gut-resident microbial genera positively correlated with radiological response to AtzBev and CD8[+] T cell infiltration, but was inversely correlated with UPD, HRD and tumour infiltration by CD68[+] monocytes. In summary, a model is proposed in which both intrinsic and extrinsic determinants in mesothelioma cooperate to modify the tumour microenvironment and confer clinical sensitivity to AtzBev. Gut microbiota represent a potentially modifiable factor with potential to improve immunotherapy outcomes for individuals with this cancer of unmet need.},
}
@article {pmid39163890,
year = {2024},
author = {Little, LD and Barnett, SE and Issitt, T and Bonsall, S and Carolan, VA and Allen, E and Cole, LM and Cross, NA and Coulson, JM and Haywood-Small, SL},
title = {Volatile organic compound analysis of malignant pleural mesothelioma chorioallantoic membrane xenografts.},
journal = {Journal of breath research},
volume = {18},
number = {4},
pages = {},
pmid = {39163890},
issn = {1752-7163},
mesh = {*Volatile Organic Compounds/analysis ; *Chorioallantoic Membrane ; Animals ; Humans ; *Mesothelioma, Malignant/pathology ; *Gas Chromatography-Mass Spectrometry ; *Pleural Neoplasms/pathology ; *Lung Neoplasms/pathology/metabolism ; Biomarkers, Tumor/analysis ; Mesothelioma/pathology ; Cell Line, Tumor ; Heterografts ; Breath Tests/methods ; Solid Phase Microextraction/methods ; },
abstract = {Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with asbestos exposure. MPM is often diagnosed late, at a point where limited treatment options are available, but early intervention could improve the chances of successful treatment for MPM patients. Biomarkers to detect MPM in at-risk individuals are needed to implement early diagnosis technologies. Volatile organic compounds (VOCs) have previously shown diagnostic potential as biomarkers when analysed in MPM patient breath. In this study, chorioallantoic membrane (CAM) xenografts of MPM cell lines were used as models of MPM tumour development for VOC biomarker discovery with the aim of generating targets for investigation in breath, biopsies or other complex matrices. VOC headspace analysis of biphasic or epithelioid MPM CAM xenografts was performed using solid-phase microextraction and gas chromatography-mass spectrometry. We successfully demonstrated the capture, analysis and separation of VOC signatures from CAM xenografts and controls. A panel of VOCs was identified that showed discrimination between MPM xenografts generated from biphasic and epithelioid cells and CAM controls. This is the first application of the CAM xenograft model for the discovery of VOC biomarkers associated with MPM histological subtypes. These findings support the potential utility of non-invasive VOC profiling from breath or headspace analysis of tissues for detection and monitoring of MPM.},
}
@article {pmid39143249,
year = {2024},
author = {Mayoral, M and Araujo-Filho, JAB and Tan, KS and Ortiz, E and Adusumilli, PS and Rusch, V and Zauderer, M and Ginsberg, MS},
title = {Are there features that can predict the unresectability of pleural mesothelioma?.},
journal = {European radiology},
volume = {},
number = {},
pages = {},
pmid = {39143249},
issn = {1432-1084},
abstract = {INTRODUCTION: The current clinical staging of pleural mesothelioma (PM) is often discordant with the pathologic staging. This study aimed to identify clinical and radiological features that could help predict unresectability in PM.<br><br>METHODS: Twenty-two descriptive radiologic features were retrospectively evaluated on preoperative computed tomography (CT) and/or positron emission tomography/CT (PET/CT) performed in patients with presumably resectable PM who underwent surgery. Measurements of maximum and sum pleural thickness at three levels of the thorax (upper, middle, and lower) were taken and stratified based on the cutpoints provided by the International Association for the Study of Lung Cancer (IASLC). Clinical and radiological features, including clinical-stage, were compared between resectable and unresectable tumors by univariate analysis and logistic regression modeling.<br><br>RESULTS: Of 133 patients, 69/133 (52%) had resectable and 64/133 (48%) had unresectable PM. Asbestos exposure (p&#x2009;=&#x2009;0.005), neoadjuvant treatment (p&#x2009;=&#x2009;0.001), clinical T-stage (p&#x2009;<&#x2009;0.0001), all pleural thickness measurements (p&#x2009;<&#x2009;0.05), pleural thickness pattern (p&#x2009;<&#x2009;0.0001) and degree (p&#x2009;=&#x2009;0.033), lung invasion (p&#x2009;=&#x2009;0.004), extrapleural space obliteration (p&#x2009;<&#x2009;0.0001), extension to subphrenic space (p&#x2009;=&#x2009;0.0004), and two combination variables representing extensive diaphragmatic contact and/or chest wall involvement (p&#x2009;=&#x2009;0.002) and mediastinal invasion (p&#x2009;<&#x2009;0.0001) were significant predictors at univariate analysis. At multivariable analysis, all models achieved a strong diagnostic performance (area under the curve (AUC)&#x2009;>&#x2009;0.8). The two best-performing models were one that included the upper-level maximum pleural thickness, extrapleural space obliteration, and mediastinal infiltration (AUC&#x2009;=&#x2009;0.876), and another that integrated clinical variables and radiological assessment through the clinical T-stage (AUC&#x2009;=&#x2009;0.879).<br><br>CONCLUSION: Selected clinical and radiologic features, including pleural thickness measurements, appear to be strong predictors of unresectability in PM.<br><br>CLINICAL RELEVANCE STATEMENT: A more accurate prediction of unresectability in the preoperative assessment of patients with pleural mesothelioma may avoid unnecessary surgery and prompt initiation of nonsurgical treatments.<br><br>KEY POINTS: About half of pleural mesothelioma patients are reported to receive an incorrect disease stage&#xa0;preoperatively. Eleven features identified as predictors of unresectability were included in strongly performing predictive models. More accurate preoperative staging will help clinicians and patients choose the most appropriate treatments.},
}
@article {pmid39138009,
year = {2024},
author = {Nash, J and Stone, E and Vinod, S and Leong, T and Dawkins, P and Stirling, RG and Harden, S and Bolton, A and McWilliams, A and O'Byrne, K and Wright, GM and Brunelli, VN and Guan, T and Philpot, S and Navani, N and Brims, F and , },
title = {Lung cancer (internet-based) Delphi (LUCiD): A modified eDelphi consensus process to establish Australasian clinical quality indicators for thoracic cancer.},
journal = {Respirology (Carlton, Vic.)},
volume = {},
number = {},
pages = {},
doi = {10.1111/resp.14812},
pmid = {39138009},
issn = {1440-1843},
abstract = {BACKGROUND AND OBJECTIVE: Approximately 16,000 new cases of lung cancer are diagnosed each year in Australia and Aotearoa New Zealand, and it is the leading cause of cancer death in the region. Unwarranted variation in lung cancer care and outcomes has been described for many years, although clinical quality indicators to facilitate benchmarking across Australasia have not been established. The purpose of this study was to establish clinical quality indicators applicable to lung and other thoracic cancers across Australia and Aotearoa New Zealand.<br><br>METHODS: Following a literature review, a modified three round eDelphi consensus process was completed between October 2022 and June 2023. Participants included clinicians from all relevant disciplines, patient advocates, researchers and other stakeholders, with representatives from all Australian states and territories and Aotearoa New Zealand. Consensus was set at a threshold of 70%, with the first two rounds conducted as online surveys, and the final round held as a hybrid in person and virtual consensus meeting.<br><br>RESULTS: The literature review identified 422 international thoracic oncology indicators, and a total of 71 indicators were evaluated over the course of the Delphi consensus. Ultimately, 27 clinical quality indicators reached consensus, covering the continuum of thoracic oncologic care from diagnosis to first line treatment. Indicators benchmarking supportive care were poorly represented. Attendant numeric quality standards were developed to facilitate benchmarking.<br><br>CONCLUSION: Twenty-seven clinical quality indicators relevant to thoracic oncology care in Australasia were developed. Real world implementation will now be explored utilizing a prospective dataset collected across Australia.},
}
@article {pmid39133306,
year = {2024},
author = {Thunold, S and Hernes, E and Farooqi, S and Öjlert, &#xc5;K and Francis, RJ and Nowak, AK and Szejniuk, WM and Nielsen, SS and Cedres, S and Perdigo, MS and Sørensen, JB and Meltzer, C and Mikalsen, LTG and Helland, &#xc5; and Malinen, E and Haakensen, VD},
title = {Outcome prediction based on [18F]FDG PET/CT in patients with pleural mesothelioma treated with ipilimumab and nivolumab +/- UV1 telomerase vaccine.},
journal = {European journal of nuclear medicine and molecular imaging},
volume = {},
number = {},
pages = {},
pmid = {39133306},
issn = {1619-7089},
support = {2020077//Helse S&#xf8;r-&#xd8;st RHF/ ; 2021083//Helse S&#xf8;r-&#xd8;st RHF/ ; },
abstract = {PURPOSE: The introduction of immunotherapy in pleural mesothelioma (PM) has highlighted the need for effective outcome predictors. This study explores the role of [18F]FDG PET/CT in predicting outcomes in PM treated with immunotherapy.<br><br>METHODS: Patients from the NIPU trial, receiving ipilimumab and nivolumab +/- telomerase vaccine in second-line, were included. [18F]FDG PET/CT was obtained at baseline (n = 100) and at week-5 (n = 76). Metabolic tumour volume (MTV) and peak standardised uptake value (SUVpeak) were evaluated in relation to survival outcomes. Wilcoxon rank-sum test was used to assess differences in MTV, total lesion glycolysis (TLG), maximum standardised uptake value (SUVmax) and SUVpeak between patients exhibiting an objective response, defined as either partial response or complete response according to the modified Response Criteria in Solid Tumours (mRECIST) and immune RECIST (iRECIST), and non-responders, defined as either stable disease or progressive disease as their best overall response.<br><br>RESULTS: Univariate Cox regression revealed significant associations of MTV with OS (HR 1.36, CI: 1.14, 1.62, p < 0.001) and PFS (HR 1.18, CI: 1.03, 1.34, p = 0.02), while multivariate analysis showed a significant association with OS only (HR 1.35, CI: 1.09, 1.68, p = 0.007). While SUVpeak was not significantly associated with OS or PFS in univariate analyses, it was significantly associated with OS in multivariate analysis (HR 0.43, CI: 0.23, 0.80, p = 0.008). Objective responders had significant reductions in TLG, SUVmax and SUVpeak at week-5.<br><br>CONCLUSION: MTV provides prognostic value in PM treated with immunotherapy. High SUVpeak was not associated with inferior outcomes, which could be attributed to the distinct mechanisms of immunotherapy. Early reductions in PET metrics correlated with treatment response.<br><br>STUDY REGISTRATION: The NIPU trial (NCT04300244) is registered at clinicaltrials.gov. https://classic.<br><br>CLINICALTRIALS: gov/ct2/show/NCT04300244?cond=Pleural+Mesothelioma&amp;cntry=NO&amp;draw=2&amp;rank=4.},
}
@article {pmid39129543,
year = {2024},
author = {Delhaise, J and Gustin, M},
title = {[Erionite, an exposure factor linked to pleural mesothelioma].},
journal = {Revue medicale de Liege},
volume = {79},
number = {7-8},
pages = {478-484},
pmid = {39129543},
issn = {0370-629X},
mesh = {Humans ; *Pleural Neoplasms/etiology/diagnosis ; *Mesothelioma/etiology/chemically induced ; Male ; Zeolites/adverse effects ; Environmental Exposure/adverse effects ; Mesothelioma, Malignant/pathology ; },
abstract = {Mesotheliomas are neoplasia developed from the mesothelium, a layer covering the viscera (visceral layer) and the cavity where the organs are (parietal layer). The best known, and the most frequently encountered is the pleural mesothelioma. This disease has a close link with exposure to asbestos, a mineral fibre now banned in several countries. However, other exposure factors have also been incriminated, including another one recognised as a certain carcinogenic agent for several years now : erionite. We present the case of a patient with pleural mesothelioma whose exposure to erionite could be demonstrated. The presentation of this clinical case will be complemented by a literature review on this less known and mostly environmental exposure, contrary to asbestos which is mostly professional.},
}
@article {pmid39114201,
year = {2024},
author = {Al-Moussally, F and Alamin, F and Khan, S and Gopalan, PK},
title = {Sarcomatoid Mesothelioma With New Pancreatic Lesions Presenting As Acute Pancreatitis: A Case Report.},
journal = {Cureus},
volume = {16},
number = {7},
pages = {e64088},
pmid = {39114201},
issn = {2168-8184},
abstract = {Sarcomatoid mesothelioma is a rare, aggressive malignancy that usually follows asbestos exposure. It is the least common subtype of mesotheliomas, following epithelial and biphasic subtypes. Pleural mesothelioma can metastasize, with the liver, kidneys, adrenal glands, and opposite lungs being the most commonly reported sites for metastasis. Metastasis of the pancreas is extremely rare, which is why the authors of this case report intend to present the case of a 78-year-old male who was found to have acute pancreatitis, most likely secondary to metastatic lesions.},
}
@article {pmid39111017,
year = {2024},
author = {Otte, N and Fraune, E and Cetiner, Y and Felten, MK and Dirrichs, T and Krabbe, J and Kraus, T},
title = {Asbestos Surveillance Program Aachen (ASPA): Cancer mortality among asbestos exposed power industry workers.},
journal = {Lung cancer (Amsterdam, Netherlands)},
volume = {195},
number = {},
pages = {107899},
doi = {10.1016/j.lungcan.2024.107899},
pmid = {39111017},
issn = {1872-8332},
mesh = {Humans ; *Occupational Exposure/adverse effects ; *Asbestos/adverse effects ; Male ; *Lung Neoplasms/mortality/etiology/epidemiology ; Middle Aged ; Female ; Aged ; Adult ; Mesothelioma/mortality/etiology ; Occupational Diseases/mortality/epidemiology ; Follow-Up Studies ; },
abstract = {BACKGROUND: The time between initial asbestos exposure and asbestos-related disease can span several decades. The Asbestos Surveillance Program aims to detect early asbestos-related diseases in a cohort of 8,565 power industry workers formerly exposed to asbestos.<br><br>RESEARCH QUESTION: How does asbestos exposure patterns affect cancer mortality and the duration of latency until death?<br><br>METHODS: A mortality follow-up was conducted with available vital status for 8,476 participants (99 %) and available death certificates for 89.9 % of deceased participants. Standardised mortality ratios (SMR) were calculated for asbestos-related cancers. The SMR of mesothelioma and lung cancer were stratified by exposure duration, cumulative asbestos exposure and smoking. The effect of age at first exposure, cumulative asbestos exposure and smoking on the duration of latency until death was examined using multiple linear regression analysis.<br><br>RESULTS: The mortality risk of mesothelioma (n&#xa0;=&#xa0;104) increased with cumulative asbestos exposure but not with exposure duration; the highest mortality (SMR: 23.20; 95&#xa0;% CI: 17.62-29.99) was observed in participants who performed activities with short extremely high exposures (steam turbine revisions). Lung cancer mortality (n&#xa0;=&#xa0;215) was not increased (SMR: 1.03; 95&#xa0;% CI: 0.89-1.17). Median latency until death was 46 (15-63) years for mesothelioma and 44 (15-70) years for lung cancer and deaths occurred between age 64 and 82&#xa0;years. Latency until death was not influenced by age at first exposure, cumulative exposure, or smoking.<br><br>CONCLUSION: Cumulative dose seems to be more appropriate than exposure duration for estimating the risk of mesothelioma death. Additionally, exposure with high cumulative doses in short time should be considered. Since only lung cancer mortality, not incidence, was recorded in this study, lung cancer risk associated with asbestos exposure could not be assessed and the lung cancer mortality was lower than expected probably due to screening effects and improved treatments. The critical time window of death from asbestos-related cancer is between the seventh and ninth decade of life. Future studies should further explore the concept of latency, especially since large ranges are reported throughout the literature.},
}
@article {pmid39083122,
year = {2024},
author = {Kraus, T and Jonigk, D},
title = {[Mesothelioma-30 years after the asbestos ban in Germany].},
journal = {Pathologie (Heidelberg, Germany)},
volume = {45},
number = {5},
pages = {305-308},
pmid = {39083122},
issn = {2731-7196},
mesh = {Humans ; Germany/epidemiology ; *Asbestos/adverse effects ; *Mesothelioma/epidemiology/history/etiology ; Occupational Diseases/epidemiology/history/prevention &amp; control ; Occupational Exposure/legislation &amp; jurisprudence/history/adverse effects/prevention &amp; control ; Incidence ; Pleural Neoplasms/epidemiology/history/etiology ; Asbestosis/epidemiology/history/prevention &amp; control/etiology ; },
abstract = {In 1993, a total asbestos ban was introduced in Germany. Thirty years later, mesothelioma is still one of the most frequent occupational diseases. Recent data on incidence, mortality, recognized occupational diseases, early detection, and assessment are presented in this article.},
}
@article {pmid39060158,
year = {2024},
author = {Gislard, A and Gramond, C and Clin, B and Paris, C and Delva, F and Brochard, P and Laurent, F and Benoist, J and Andujar, P and Chouaïd, C and Thaon, I and Boudet, L and Pairon, JC},
title = {[Compensation of occupational diseases during monitoring of the ARDCO cohort].},
journal = {Revue des maladies respiratoires},
volume = {41},
number = {7},
pages = {472-487},
doi = {10.1016/j.rmr.2024.06.010},
pmid = {39060158},
issn = {1776-2588},
mesh = {Humans ; France/epidemiology ; *Occupational Diseases/epidemiology/diagnosis/etiology ; Male ; Middle Aged ; Female ; *Occupational Exposure/adverse effects/statistics &amp; numerical data ; Aged ; *Asbestosis/epidemiology/diagnosis ; Cohort Studies ; *Lung Neoplasms/epidemiology/diagnosis/etiology ; *Workers' Compensation/statistics &amp; numerical data ; *Asbestos/adverse effects ; Adult ; Aged, 80 and over ; Tomography, X-Ray Computed/statistics &amp; numerical data ; Mesothelioma/epidemiology/diagnosis/etiology ; },
abstract = {INTRODUCTION: Questions concerning under-reporting of occupational diseases (OD) linked to asbestos exposure are regularly voiced in France. Monitoring of the French multicenter Asbestos-Related Disease Cohort (ARDCO), which ensures post-occupational medical surveillance of subjects having been exposed to asbestos, provides information on (1) the medico-legal steps taken following screening by computed tomography (CT) for benign thoracic diseases, and (2) recognition of OD as a causal factor in malignant diseases.<br><br>METHODS: OD recognition -&#xa0;and possible compensation&#xa0;- was analyzed in July 2021 among 13,289 volunteers in the cohort recruited between 2003 and 2005.<br><br>RESULTS: Fifteen percent of the subjects in the cohort were found to have at least one recognized asbestos-related OD (78.2% benign pleural disease, 10.3% asbestosis, 14.2% lung cancer, and 6.0% mesothelioma). Only 58% of pleural plaques reported by the radiologist who performed the CT resulted in their recognition as ODs. On a parallel track, 88.7% of the mesotheliomas identified based on French National health insurance data and 46.9% of lung cancers were recognized as ODs.<br><br>CONCLUSIONS: This study confirms the feasibility of a system designed to facilitate recognition, leading to possible compensation, of asbestos-related occupational diseases. The system could be improved by better training of the medical actors involved.},
}
@article {pmid39015660,
year = {2024},
author = {Neilly, MDJ and Pearson, J and Thu, AW and MacRae, C and Blyth, KG},
title = {Contemporary management of mesothelioma.},
journal = {Breathe (Sheffield, England)},
volume = {20},
number = {2},
pages = {230175},
pmid = {39015660},
issn = {1810-6838},
abstract = {Pleural mesothelioma (PM) is an aggressive asbestos-associated thoracic malignancy with a median survival of 12-18 months. Due to continued asbestos use in many nations, global incidence is rising. Causes due to non-occupational, environmental exposure are also rising in many countries despite utilisation bans. For many years, platinum--pemetrexed chemotherapy was the solitary licensed therapy, but first-line combination immune checkpoint blockade has recently demonstrated improved outcomes, with both regimes tested in predominantly late-stage cohorts. In the second-line setting, single-agent nivolumab has been shown to extend survival and is now available for routine use in some regions, while second-line chemotherapy has no proven role and opportunities for clinical trials should be maximised in relapsed disease. Surgery for "technically resectable" disease has been offered for decades in many expert centres, but the recent results from the phase III MARS2 trial have challenged this approach. There remains no robustly proven standard of care for early-stage PM. The clinical trial landscape for PM is complex and increasingly diverse, making further development of specialist PM multidisciplinary teams an important priority in all countries. The observation of improving outcomes in centres that have adopted this service model emphasises the importance of high-quality diagnostics and equitable access to therapies and trials. Novel therapies targeting a range of aberrations are being evaluated; however, a better understanding of the molecular drivers and their associated vulnerabilities is required to identify and prioritise treatment targets.},
}
@article {pmid39015649,
year = {2024},
author = {Cravero, JC and Yakubik, T and Wahab, L and Giang, T and Lopez, LM and Newman, MG},
title = {Primary Peritoneal Mesothelioma Affecting the Greater Omentum That Mimicked an Omental Infarction: A Case Report.},
journal = {Case reports in oncology},
volume = {17},
number = {1},
pages = {596-601},
pmid = {39015649},
issn = {1662-6575},
abstract = {INTRODUCTION: Malignant peritoneal mesothelioma (MPM) is a rare cancer that is associated with asbestos exposure. The diagnosis can be difficult given the nonspecific nature of presenting symptoms and the presence of concomitant confounding findings.<br><br>CASE PRESENTATION: We report a 71-year-old male who presented with right lower quadrant pain and new-onset ascites. CT imaging of the abdomen/pelvis demonstrated omental stranding concerning for a possible omental infarction. Subsequent imaging showed persistent omental edema but no identifiable soft tissue mass. A biopsy of the omentum showed atypical mesothelial proliferation, but pathology was unable to determine if proliferation was a neoplastic versus reactive process. Surgical oncology performed a diagnostic laparoscopy that showed peritoneal studding of the omentum. Subsequent immunohistochemical staining of the omentum demonstrated preservation of BAP1 expression and loss of MTAP expression, consistent with peritoneal mesothelioma.<br><br>CONCLUSION: MPM is a rare and aggressive cancer with an overall poor prognosis. The diagnosis of MPM can be difficult based on the nonspecific clinical presentation, insufficient imaging and laboratory testing, and the presence of concomitant confounding findings, such as with this patient and his admitting diagnosis of omental infarction. This case demonstrates the importance of developing a broad differential while maintaining an awareness of heuristics that can influence clinical decision-making.},
}
@article {pmid39014872,
year = {2024},
author = {Khan, S and Malik, A and Qureshi, S and Cohen, B and Nadir, A},
title = {Incidental Diagnosis of Malignant Peritoneal Mesothelioma During Liver Transplantation Surgery: A Case Report.},
journal = {The American journal of case reports},
volume = {25},
number = {},
pages = {e943787},
pmid = {39014872},
issn = {1941-5923},
mesh = {Humans ; *Liver Transplantation ; Female ; *Peritoneal Neoplasms/diagnosis ; Middle Aged ; *Incidental Findings ; *Mesothelioma, Malignant/diagnosis ; Mesothelioma/diagnosis ; Lung Neoplasms/diagnosis ; },
abstract = {BACKGROUND Malignant peritoneal mesothelioma (MPM) is a rare, lethal tumor of serous membranes. The most common factor reported in association with MPM is asbestos exposure, while viral infections, genetic predisposition, paraneoplastic syndrome, and altered immunity have been described as well. The diagnosis can be challenging among those with lower tumor burden as well as nonspecific symptoms, and it is not unusual to discover the diagnosis incidentally. CASE REPORT A middle-aged woman with decompensated cirrhosis underwent extensive pre-transplant workup, showing no evidence of malignancy. She had a personal history of asbestos exposure and family history of MPM in the extended family. During transplant surgery, a few peritoneal nodules were noted, leading to termination of the procedure. Pathological analysis confirmed malignant MPM. A multidisciplinary discussion led to following a conservative treatment approach without any intervention, due to higher risk of worsening hepatic decompensation associated with peritonectomy and intraperitoneal chemotherapy. The patient's hepatic decompensation resolved 6 months after the aborted liver transplant operation. Since the diagnosis of MPM, positron emission tomography scans have shown no recurrence of MPM for 3 consecutive years. CONCLUSIONS This is the first case of MPM diagnosed incidentally during a liver transplantation surgery. This case highlights the challenges in the diagnosis and management of MPM in a patient with decompensated liver disease. A multidisciplinary approach and following a consensus decision led to prolonged survival in the described patient.},
}
@article {pmid39011477,
year = {2024},
author = {Costa, A and Forte, IM and Pentimalli, F and Iannuzzi, CA and Alfano, L and Capone, F and Camerlingo, R and Calabrese, A and von Arx, C and Benot Dominguez, R and Quintiliani, M and De Laurentiis, M and Morrione, A and Giordano, A},
title = {Pharmacological inhibition of CDK4/6 impairs diffuse pleural mesothelioma 3D spheroid growth and reduces viability of cisplatin-resistant cells.},
journal = {Frontiers in oncology},
volume = {14},
number = {},
pages = {1418951},
pmid = {39011477},
issn = {2234-943X},
abstract = {INTRODUCTION: Diffuse pleural mesothelioma (DPM) of the pleura is a highly aggressive and treatment-resistant cancer linked to asbestos exposure. Despite multimodal treatment, the prognosis for DPM patients remains very poor, with an average survival of 2 years from diagnosis. Cisplatin, a platinum-based chemotherapy drug, is commonly used in the treatment of DPM. However, the development of resistance to cisplatin significantly limits its effectiveness, highlighting the urgent need for alternative therapeutic strategies. New selective inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) have shown promise in various malignancies by inhibiting cell cycle progression and suppressing tumor growth. Recent studies have indicated the potential of abemaciclib for DPM therapy, and a phase II clinical trial has shown preliminary encouraging results.<br><br>METHODS: Here, we tested abemaciclib, palbociclib, and ribociclib on a panel of DPM cell lines and non-tumor mesothelial(MET-5A) cells.<br><br>RESULTS: Specifically, we focused on abemaciclib, which was the mosteffective cytotoxic agent on all the DPM cell lines tested. Abemaciclib reduced DPM cell viability, clonogenic potential, and ability to grow as three-dimensional (3D) spheroids. In addition, abemaciclib induced prolonged effects, thereby impairing second-generation sphere formation and inducing G0/G1 arrest and apoptosis/ necrosis. Interestingly, single silencing of RB family members did not impair cell response to abemaciclib, suggesting that they likely complement each other in triggering abemaciclib's cytostatic effect. Interestingly, abemaciclib reduced the phosphorylation of AKT, which is hyperactive in DPM and synergized with the pharmacological AKT inhibitor (AKTi VIII). Abemaciclib also synergized with cisplatin and reduced the viability of DPM cells with acquired resistance to cisplatin.<br><br>DISCUSSION: Overall, our results suggest that CDK4/6 inhibitors alone or in combination with standard of care should be further explored for DPM therapy.},
}
@article {pmid39006698,
year = {2024},
author = {Sonobe, H and Omote, R and Habara, T and Washio, K and Yamazoe, N and Matsumoto, S and Nabeshima, K and Toda, H},
title = {A Rare Case of Pleural Epithelioid Mesothelioma With a Prominent Myxoid Stroma Reported With Morphology, Fluorescent In Situ Hybridization, and Ultrastructural Findings.},
journal = {Cureus},
volume = {16},
number = {6},
pages = {e62212},
pmid = {39006698},
issn = {2168-8184},
abstract = {Herein, we report a rare case of pleural epithelioid malignant mesothelioma with a prominent myxoid stroma. To date, detailed morphological or molecular pathological findings have not been reported for this type of tumor. Hence, we aimed to describe the cytological, histological, immuno-cytohistological, electron-microscopic, and molecular pathological findings using fluorescence in situ hybridization (FISH) in such a case. The patient was a male in his mid-sixties with a history of asbestos exposure and had originally visited the hospital with a persistent cough and fever. Chest radiography revealed left pleural effusion, and laboratory examination revealed a high titer for hyaluronic acid in the effusion. Additionally, computed tomography revealed diffuse multinodular or cystic lesions in the left parietal pleura, and pleural effusion cytology revealed large epithelioid cells with mild nuclear atypia, which were considered reactive mesothelial cells. Cytologically, Giemsa staining revealed that these cells harbored variously sized intracytoplasmic vacuoles that were Alcian-blue-positive, suggesting hyaluronan production. Biopsy revealed large epithelioid cells that loosely proliferated against a prominent myxoid background. These cells were immuno-positive for calretinin, Wilms' tumor 1, D2-40, vimentin, and cytokeratin AE1/AE3 but not for carcinoembryonic antigen, Ber-EP4, or desmin. BRCA 1 associated protein 1 immunostaining showed nuclear loss, and FISH showed homozygous deletion of cyclin-dependent kinase inhibitor 2A (p16) on chromosome 9p21. Based on these findings, the lesion was diagnosed as an epithelioid mesothelioma with a prominent myxoid stroma. Electron-microscopy demonstrated a dense microvillus pattern on the surface of the tumor cells, indicating a mesothelial cell origin, and variously sized vacuoles in the cytoplasm, confirming the presence of intracytoplasmic vacuoles demonstrated on cytology. The tumor tissues obtained during surgery harbored prominent myxoid stroma, which proved that the present tumor was consistent with this type of mesothelioma. After informed consent was obtained, the patient and family wished for total resection of the tumor and postoperative chemotherapy, and the patient eventually died eight months after surgery.},
}
@article {pmid39003938,
year = {2024},
author = {van Zandwijk, N and Frank, AL and Reid, G and Dimitri Røe, O and Amos, CI},
title = {Asbestos-Related lung Cancer: An underappreciated oncological issue.},
journal = {Lung cancer (Amsterdam, Netherlands)},
volume = {194},
number = {},
pages = {107861},
doi = {10.1016/j.lungcan.2024.107861},
pmid = {39003938},
issn = {1872-8332},
mesh = {Humans ; *Lung Neoplasms/etiology/epidemiology ; *Asbestos/adverse effects ; Environmental Exposure/adverse effects ; Incidence ; Air Pollution/adverse effects ; Occupational Exposure/adverse effects ; Particulate Matter/adverse effects ; },
abstract = {Asbestos, a group of class I (WHO) carcinogenic fibers, is the main cause of mesothelioma. Asbestos inhalation also increases the risk to develop other solid tumours with lung cancer as the most prominent example [91]. The incidence of asbestos-related lung cancer (ARLC) is estimated to be to six times larger than the mesothelioma incidence thereby becoming an important health issue [86]. Although the pivotal role of asbestos in inducing lung cancer is well established, the precise causal relationships between exposures to asbestos, tobacco smoke, radon and 'particulate' (PM2.5) air pollution remain obscure and new knowledge is needed to establish appropriate preventive measures and to tailor existing screening practices[22,61,65]. We hypothesize that a part of the increasing numbers of lung cancer diagnoses in never-smokers can be explained by (historic and current) exposures to asbestos as well as combinations of different forms of air pollution (PM2.5, asbestos and silica).},
}
@article {pmid38995135,
year = {2024},
author = {Mirabelli, D and Terracini, B},
title = {Carcinogenicity of asbestos-free talc and talcum powder: A systematic review of the epidemiological evidence after the 2006 monograph of the International Agency for Research on Cancer.},
journal = {Epidemiologia e prevenzione},
volume = {48},
number = {3},
pages = {220-232},
doi = {10.19191/EP24.3.A688.057},
pmid = {38995135},
issn = {1120-9763},
mesh = {Female ; Humans ; Male ; Carcinogens/toxicity ; Case-Control Studies ; Cosmetics ; Endometrial Neoplasms/epidemiology/chemically induced ; Lung Neoplasms/epidemiology/chemically induced/etiology ; Neoplasms/epidemiology/chemically induced/etiology ; *Occupational Diseases/epidemiology/chemically induced ; *Occupational Exposure/adverse effects ; Ovarian Neoplasms/epidemiology/chemically induced ; *Talc/adverse effects ; },
abstract = {BACKGROUND: in 2006, the International Agency for Research on Cancer (IARC) concluded that the evidence of carcinogenicity for asbestos-free talc was inadequate (group 3), whereas perineal use of talcum powder was classified as possibly carcinogenic (group 2B).<br><br>OBJECTIVES: to assess whether later studies provide more solid information on the carcinogenic risk from asbestos-free talc and talcum powder and a better characterization of exposure.<br><br>DESIGN: systematic review.<br><br>METHODS: cohort studies of talc miners and millers exposed to asbestos-free talc, as well as cohort and case-control studies reporting cancer risk in talc powder consumers published from 2006 onwards were identified through PubMed and reference lists. Pooled analyses were included, but not reviews and meta-analyses. In the case of repeatedly reported studies, the article with the longest follow-up or the largest number of observed cases was selected for data abstraction. Notice was taken of studies which were both reported individually and included in pooled analyses.<br><br>RESULTS: publications meeting inclusion criteria were: 2 cohort studies on talc miners and millers, 10 cohort studies on talcum powder users (4 of which estimated ovarian cancer risk), and 14 case-control studies (13 on ovarian and 1 on endometrial cancer) on the risk from talcum powder use. No excess cancer mortality has been reported among asbestos-free talc miners and millers. Case-control studies consistently led to estimates of ovarian cancer excesses associated with the use of perineal talcum powder (odds ratios up to 1.5). Most studies quantifying exposure also provided evidence of a dose-response relationship. Individual cohort studies estimated hazard ratios (HR) just above 1. In an analysis of pooled cohorts for a total of 3,112 cases, the HR for women with patent reproductive tract was 1.13 (95%CI 1.01-1.26) with a correlation between HR and frequency of use (p for trend 0.03). In all cohort studies, the perineal use of talcum powder was measured only once in the early phases of follow-up, thus producing an inaccurate measure of cumulative exposure. Results of epidemiological studies regarding cancer risk in other organs are limited and inconsistent.<br><br>CONCLUSIONS: epidemiological studies updated or published after IARC 2006 evaluation indicate that: no increase in cancer risk is apparent among miners and millers of asbestos-free talc; risk for ovarian cancer increases following the perineal use of commercial talcum powder. A correlation between indicators of quantity of use and cancer risk is suggested by a number of studies. The composition of talcum powders considered in such studies is not known.},
}
@article {pmid38990952,
year = {2024},
author = {Novelli, F and Yoshikawa, Y and Vitto, VAM and Modesti, L and Minaai, M and Pastorino, S and Emi, M and Kim, JH and Kricek, F and Bai, F and Onuchic, JN and Bononi, A and Suarez, JS and Tanji, M and Favaron, C and Zolondick, AA and Xu, R and Takanishi, Y and Wang, Z and Sakamoto, G and Gaudino, G and Grzymski, J and Grosso, F and Schrump, DS and Pass, HI and Atanesyan, L and Smout, J and Savola, S and Sarin, KY and Abolhassani, H and Hammarström, L and Pan-Hammarström, Q and Giorgi, C and Pinton, P and Yang, H and Carbone, M},
title = {Germline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling.},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
volume = {121},
number = {29},
pages = {e2405231121},
pmid = {38990952},
issn = {1091-6490},
support = {R01 CA198138/CA/NCI NIH HHS/United States ; S10 OD028515/OD/NIH HHS/United States ; 853057/ERC_/European Research Council/International ; IG-19803//Italian Association for Cancer Research/ ; PRIN2017E5L5P3 t//AROSE, Progetti di Rilevante Interesse Nazionale/ ; C-1792//Welch Foundation (The Welch Foundation)/ ; GR-2013-02356747//Italian Ministry of Health/ ; R01 ES030948/ES/NIEHS NIH HHS/United States ; 5U01CA214195-04//the Early Detection Research Network NCI/ ; 1R01ES030948-01//HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)/ ; IG-23670//Italian Association for Cancer Research/ ; 1R01CA237235-01A1//HHS | NIH | National Cancer Institute (NCI)/ ; 1R01CA198138//US Department of Defence/ ; R01 CA237235/CA/NCI NIH HHS/United States ; PHY-2019745//NSF/ ; U01 CA214195/CA/NCI NIH HHS/United States ; PRIN20177E9EPY//AROSE, Progetti di Rilevante Interesse Nazionale/ ; },
mesh = {Humans ; *DNA Repair/genetics ; *Tumor Suppressor Proteins/genetics/metabolism ; *Germ-Line Mutation ; *Ubiquitin-Protein Ligases/genetics/metabolism ; *Mesothelioma/genetics ; *Genetic Predisposition to Disease ; *Calcium Signaling/genetics ; Female ; Male ; Middle Aged ; Tumor Suppressor Protein p53/genetics/metabolism ; Apoptosis/genetics ; Fibroblasts/metabolism ; Asbestos/toxicity ; Genomic Instability ; },
abstract = {We report that ~1.8% of all mesothelioma patients and 4.9% of those younger than 55, carry rare germline variants of the BRCA1 associated RING domain 1 (BARD1) gene that were predicted to be damaging by computational analyses. We conducted functional assays, essential for accurate interpretation of missense variants, in primary fibroblasts that we established in tissue culture from a patient carrying the heterozygous BARD1[V523A] mutation. We found that these cells had genomic instability, reduced DNA repair, and impaired apoptosis. Investigating the underlying signaling pathways, we found that BARD1 forms a trimeric protein complex with p53 and SERCA2 that regulates calcium signaling and apoptosis. We validated these findings in BARD1-silenced primary human mesothelial cells exposed to asbestos. Our study elucidated mechanisms of BARD1 activity and revealed that heterozygous germline BARD1 mutations favor the development of mesothelioma and increase the susceptibility to asbestos carcinogenesis. These mesotheliomas are significantly less aggressive compared to mesotheliomas in asbestos workers.},
}
@article {pmid38970770,
year = {2024},
author = {Cedres, S and Calvete, J and Taylor-Stokes, G and Ayerza, N&#xc1; and Larena, DV and Daumont, M},
title = {Treatment patterns and humanistic burden of malignant pleural mesothelioma in Spain.},
journal = {Clinical &amp; translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico},
volume = {},
number = {},
pages = {},
pmid = {38970770},
issn = {1699-3055},
abstract = {PURPOSE: Malignant pleural mesothelioma (MPM) is an aggressive cancer with long latency and poor prognosis. The real-world treatment patterns and humanistic burden of MPM in an international cohort of patients were recently published. Spanish data are currently lacking and are reported here.<br><br>METHODS/PATIENTS: Data were collected from three sources: physician-abstracted demographic, clinical and treatment characteristics of patients with MPM; patient-completed questionnaires on treatment satisfaction, symptoms, caregiver use, and impact of the disease; and caregiver-completed questionnaire reporting their activity and its impact on their daily life.<br><br>RESULTS: The 241 patients in Spain were primarily elderly (median age: 67 years), male, retired/unemployed/on long-term sick leave, and diagnosed at stage IV with unresectable disease. Exposure to asbestos was detected (54%, 101/188). First-line treatment (1L) consisted primarily of doublet chemotherapy (86%, 207/241). Of 102 patients who completed 1L at data abstraction, 67 were receiving maintenance therapy, most commonly singlet chemotherapy with pemetrexed. Best supportive care was given to 29 patients, primarily after 1L (86.2%, 25/29). Symptom burden was high and health-related quality of life was poor and declined with progression: mean (SD) EQ-5D score and EQ-5D visual analogue scale score were 0.615 (0.285) and 60.8 (17.1) in 1L and 0.497 (0.370) and 56.1 (19.5) in second line. Overall, 67% of patients (162/241) required daily assistance from their caregiver, who reported an impact on their psychological well-being.<br><br>CONCLUSIONS: Patients with MPM in Spain were overall treated according to treatment guidelines at the time. Nevertheless, a considerable burden of disease was reported by patients and caregivers.},
}
@article {pmid38968839,
year = {2024},
author = {Andersson, EM and Barregard, L and Akerstrom, M and Sallsten, G and Järvholm, B and Nilsson, RI},
title = {Cancer incidence in Swedish oil refinery workers exposed to benzene.},
journal = {International journal of hygiene and environmental health},
volume = {261},
number = {},
pages = {114420},
doi = {10.1016/j.ijheh.2024.114420},
pmid = {38968839},
issn = {1618-131X},
mesh = {Humans ; *Benzene/toxicity ; Sweden/epidemiology ; *Occupational Exposure/adverse effects ; Male ; Incidence ; *Oil and Gas Industry ; Middle Aged ; Adult ; *Leukemia/epidemiology/chemically induced ; Occupational Diseases/epidemiology/chemically induced ; Retrospective Studies ; Neoplasms/epidemiology/chemically induced ; Air Pollutants, Occupational ; },
abstract = {BACKGROUND: Oil refinery workers are exposed to benzene, which is a well-known cause of leukaemia, but results on leukaemia in oil refinery workers have been mixed, and the data on workers' exposure is limited. Oil refinery workers are also exposed to asbestos and several studies have shown increased risk of mesothelioma.<br><br>AIM: The objective was to investigate cancer incidence, especially leukaemia, at low to moderate exposure to benzene in an update of a previous study of employees at three Swedish oil refineries.<br><br>METHODS: Cancer incidence was followed up in 2264 men (1548 refinery operators) employed at three oil refineries in Sweden for at least one year. Job types and employment times were collected from complete company files. A retrospective assessment of the benzene exposure was performed by occupational hygienists in collaboration with the refineries using historic measurements as well as detailed information on changes in the industrial hygiene and technological developments. Cases of cancer were retrieved by a linkage with the Swedish Cancer Register through 35-47 years of follow-up and standardized incidence ratios (SIR) with 95% confidence intervals (CI) were calculated.<br><br>RESULTS: In total, 258 tumors had occurred versus 240 expected (SIR 1.07; 95% CI 0.95-1.21). There were 10 cases of leukaemia, all in refinery operators (SIR 2.4; 95% CI 1.18-4.51). There were three cases of pleural mesothelioma, two of which in refinery operators. The mean estimated cumulative benzene exposure for the cases of leukaemia was 7.9&#xa0;ppm-years (median 4.9, range 0.1-31.1).<br><br>DISCUSSION: The study suggests that low to moderate average cumulative benzene exposure increases the risk of leukaemia. Limitations include the modest number of cases and potential misclassification of exposure.<br><br>CONCLUSION: The present study indicated an increased risk of leukaemia in male oil refinery workers with low to moderate exposure to benzene.},
}
@article {pmid38955483,
year = {2024},
author = {Berge, LAM and Shala, NK and Barone-Adesi, F and Hosgood, HD and Samuelsen, SO and Bråtveit, M and Kirkeleit, J and Silverman, D and Friesen, MC and Babigumira, R and Grimsrud, TK and Veierød, MB and Stenehjem, JS},
title = {Exposure to fibres and risk of pleural mesothelioma in the Norwegian Offshore Petroleum Workers cohort.},
journal = {Occupational and environmental medicine},
volume = {81},
number = {7},
pages = {331-338},
doi = {10.1136/oemed-2024-109424},
pmid = {38955483},
issn = {1470-7926},
mesh = {Humans ; Norway/epidemiology ; *Occupational Exposure/adverse effects ; Male ; *Asbestos/adverse effects ; Middle Aged ; *Mesothelioma/epidemiology/etiology/chemically induced ; *Pleural Neoplasms/epidemiology/etiology/chemically induced ; *Occupational Diseases/epidemiology/chemically induced/etiology ; Adult ; Aged ; *Ceramics/adverse effects ; *Petroleum/adverse effects ; Cohort Studies ; Mesothelioma, Malignant/epidemiology/etiology ; Risk Factors ; Oil and Gas Industry ; Lung Neoplasms/epidemiology/etiology/chemically induced ; Mineral Fibers/adverse effects ; Case-Control Studies ; Proportional Hazards Models ; },
abstract = {OBJECTIVES: Pleural mesothelioma is a rare respiratory cancer, mainly caused by inhalation of asbestos fibres. Other inorganic fibres are also suggested risk factors. We aimed to investigate the association between exposure to asbestos or refractory ceramic fibres (RCFs) and pleural mesothelioma among male Norwegian offshore petroleum workers.<br><br>METHODS: Among 25 347 men in the Norwegian Offshore Petroleum Workers (NOPW) cohort (1965-1998), 43 pleural mesothelioma cases were identified through the Cancer Registry of Norway (1999-2022). A case-cohort study was conducted with 2095 randomly drawn non-cases from the cohort. Asbestos and RCF exposures were assessed with expert-made job-exposure matrices (JEMs). Weighted Cox regression was used to estimate HRs and 95% CIs, adjusted for age at baseline and pre-offshore employment with likely asbestos exposure.<br><br>RESULTS: An increased risk of pleural mesothelioma was indicated for the highest versus lowest tertile of average intensity of asbestos (HR=1.21, 95%&#x2009;CI: 0.57 to 2.54). Pre-offshore asbestos exposure (vs no such exposure) was associated with increased risk of pleural mesothelioma (HR=2.06, 95%&#x2009;CI: 1.11 to 3.81). For offshore workers with no pre-offshore asbestos exposure, an increased risk of pleural mesothelioma was found for the highest tertile of average intensity of asbestos (HR=4.13, 95%&#x2009;CI: 0.93 to 18), versus the lowest tertile. No associations were found between RCF and pleural mesothelioma.<br><br>CONCLUSIONS: Associations between JEM-based offshore asbestos exposure and pleural mesothelioma were confirmed in the NOPW cohort. Pleural mesothelioma risk was also associated with asbestos exposure before work in the offshore petroleum industry.},
}
@article {pmid38954660,
year = {2024},
author = {Zhao, Z and Li, J and Tan, F and Xue, Q and Gao, S and He, J},
title = {Assessing the global burden of mesothelioma: trends, socioeconomic influences, and asbestos exposure: a retrospective cohort study.},
journal = {International journal of surgery (London, England)},
volume = {},
number = {},
pages = {},
doi = {10.1097/JS9.0000000000001900},
pmid = {38954660},
issn = {1743-9159},
abstract = {INTRODUCTION: Mesothelioma is an uncommon type of cancer which has received little attention. This study aims to evaluate the global disease burden; trends of mesothelioma by age, sex, and geographic locations; and its risk factors on the population level.<br><br>METHODS: The Global Cancer Observatory in 2022 and 2019 Global Burden of Disease were accessed for mesothelioma incidence and its risk factors worldwide. Multivariable linear regression analyses was conducted to explore the associations between mesothelioma incidence and key predictors including Human Development Index (HDI), Gross Domestic Product (GDP) per capita, and occupational asbestos exposure, adjusting for age and sex across global regions.<br><br>RESULTS: This study identified 30,870 global cases of mesothelioma in 2022, with a higher age-standardized incidence rate (ASR) in males (0.25 per 100,000) compared to females (0.39 per 100,000). Geographical analysis indicated the highest disease burden in Northern Europe, with particular prevalence in more developed regions. The incidence was also significantly associated with higher Human Development Index (HDI), with a beta coefficient of 0.133 overall, and Gross Domestic Product (GDP) per capita, with a beta coefficient of 0.101. These socioeconomic factors exhibited stronger associations in the elderly population, especially with HDI (&#x3b2;=0.512) and GDP (&#x3b2;=0.389), than in adults. Additionally, occupational exposure to asbestos remained a significant risk factor across all groups, except for the younger adult population, with an overall beta of 0.122 for incidence. The temporal trend analysis revealed a general decrease in mesothelioma incidence, particularly in the 15-49 years age group.<br><br>CONCLUSIONS: The analysis indicates a higher mesothelioma incidence in males and in developed regions, with marked disparities noted particularly in Northern Europe. Significant correlations with socioeconomic indicators-HDI and GDP-and occupational asbestos exposure were identified, particularly affecting the elderly. Despite a decline in global incidence, especially among younger individuals, persistent cases in females highlight the need for continued public health measures addressing both occupational and environmental exposures.},
}
@article {pmid38952736,
year = {2024},
author = {De Maria, L and Pentimone, F and Cavone, D and Caputi, A and Sponselli, S and Fragassi, F and Dicataldo, F and Luisi, V and Delvecchio, G and Giannelli, G and Cafaro, F and Sole, S and Ronghi, C and Zagaria, S and Loiacono, G and Sifanno, G and Ferri, GM and Vimercati, L},
title = {Clinical investigation of former workers exposed to asbestos: the health surveillance experience of an Italian University Hospital.},
journal = {Frontiers in public health},
volume = {12},
number = {},
pages = {1411910},
pmid = {38952736},
issn = {2296-2565},
mesh = {Humans ; Italy/epidemiology ; *Occupational Exposure/adverse effects ; Male ; *Asbestos ; *Hospitals, University ; Female ; Middle Aged ; *Asbestosis/epidemiology ; Aged ; Mesothelioma, Malignant ; Adult ; Lung Neoplasms/epidemiology/etiology ; Population Surveillance ; Pleural Neoplasms/epidemiology/etiology ; Mesothelioma/epidemiology/etiology ; },
abstract = {BACKGROUND: The need for health surveillance of former workers exposed to asbestos was provided by law in Italy after the asbestos ban in 1992.<br><br>OBJECTIVES: We describe the results of the health surveillance of former workers exposed to asbestos, conducted over 27 years, from 1994 to 2020, at the Operative Unit of Occupational Medicine of the University Hospital of Bari.<br><br>MATERIALS AND METHODS: We adopted the health surveillance protocol, which was validated at the national level in 2018.<br><br>RESULTS: A total of 1,405 former workers exposed to asbestos were examined. We proceeded with diagnosing pathologies in 339 cases (24% of the cohort subjected to surveillance), with diagnoses of some cases involving multiple pathologies. Specifically, pleural plaques were diagnosed in 49.2% of the 339 cases, asbestosis in 35.9%, malignant pleural mesothelioma (MPM) in 20.3%, mesothelioma of the vaginal tunic of the testis (MTVT) in 9.1%, lung cancer in 5.8%, and laryngeal cancer in 0.8%.<br><br>CONCLUSION: Despite the 1992 asbestos ban, asbestos-related diseases remain a serious public health issue. It is important to establish criteria that ensure the health surveillance of formerly exposed workers minimizes costs, reduces the number of invasive examinations, and optimizes achievable results.},
}
@article {pmid38951010,
year = {2024},
author = {Sherborne, V and Ejegi-Memeh, S and Tod, AM and Taylor, B and Hargreaves, S and Gardiner, C},
title = {Living with mesothelioma: a systematic review of mental health and well-being impacts and interventions for patients and their informal carers.},
journal = {BMJ open},
volume = {14},
number = {6},
pages = {e075071},
pmid = {38951010},
issn = {2044-6055},
mesh = {Humans ; *Mesothelioma/psychology/therapy ; *Caregivers/psychology ; *Mental Health ; Quality of Life ; Anxiety/etiology ; Depression/etiology ; },
abstract = {OBJECTIVES: Mesothelioma is an aggressive cancer predominantly affecting the lung and abdominal linings. It can have a unique impact on mental health and well-being (MHWB) due to its incurability, poor prognosis and asbestos-exposure causation. This review's aims were to identify/synthesise international evidence on mesothelioma's MHWB impacts; explore MHWB interventions used by patients and carers; and identify evidence of their effectiveness.<br><br>DESIGN: Systematic review.<br><br>DATA SOURCES: Databases, searched March 2022 and March 2024, were MEDLINE; CINAHL; PsycINFO; Cochrane Library; ASSIA.<br><br>ELIGIBILITY CRITERIA: We included study designs focusing on psychological impacts of living with mesothelioma and MHWB interventions used by patients and informal carers, published in English since January 2002.<br><br>DATA EXTRACTION AND SYNTHESIS: A team of reviewers screened included studies using standardised methods. Quality was assessed using validated tools: Mixed-Methods Appraisal tool for primary research and Joanna Briggs Institute Critical Appraisal Checklist for Systematic Reviews.<br><br>RESULTS: Forty-eight studies met the inclusion criteria: 20 qualitative, 16 quantitative, nine reviews, two mixed-methods, one combined systematic review/qualitative study. UK studies predominated. Many MHWB impacts were reported, including traumatic stress, depression, anxiety and guilt. These were influenced by mesothelioma's causation, communication issues and carer-patient relational interactions. Participants used wide-ranging MHWB interventions, including religious/spiritual practice; talking to mental-health professionals; meaning-making. Some strategies were presented as unhelpful, for example, denial. Participants reported lack of access to support.<br><br>CONCLUSIONS: Most qualitative studies were rated high quality. The quality of the quantitative studies and reviews varied. The sparse literature regarding MHWB in mesothelioma means more research is needed into impacts on patients and carers, including trauma. To enable access to evidence-based support, research is recommended concerning MHWB interventions' effectiveness in mesothelioma.<br><br>PROSPERO REGISTRATION NUMBER: CRD42022302187.},
}
@article {pmid38943482,
year = {2024},
author = {Girardi, P and Rigoni, S and Ferrante, D and Silvestri, S and Angelini, A and Cuccaro, F and Oddone, E and Vicentini, M and Barone-Adesi, F and Tunesi, S and Migliore, E and Roncaglia, F and Sala, O and Pirastu, R and Chellini, E and Miligi, L and Perticaroli, P and Bressan, V and Merler, E and Azzolina, D and Marinaccio, A and Massari, S and Magnani, C},
title = {Asbestos exposure and asbestosis mortality in Italian cement-asbestos cohorts: Dose-response relationship and the role of competing death causes.},
journal = {American journal of industrial medicine},
volume = {67},
number = {9},
pages = {813-822},
doi = {10.1002/ajim.23629},
pmid = {38943482},
issn = {1097-0274},
support = {//Istituto Superiore di Sanit&#xe0;/ ; //Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro/ ; //The Italian National Institute of Health (ISS)/ ; //The INAIL/ ; },
mesh = {Humans ; *Asbestosis/mortality ; Italy/epidemiology ; *Occupational Exposure/adverse effects/analysis ; Male ; *Asbestos ; Middle Aged ; *Construction Materials/adverse effects ; Female ; *Cause of Death ; Aged ; Cohort Studies ; *Lung Neoplasms/mortality ; Pleural Neoplasms/mortality ; Proportional Hazards Models ; Peritoneal Neoplasms/mortality ; Occupational Diseases/mortality ; Adult ; Dose-Response Relationship, Drug ; },
abstract = {OBJECTIVES: In Italy, asbestos was used intensively until its ban in 1992, which was extended for asbestos cement factories until 1994. The aim of this study was to evaluate the dose-response between asbestos exposure and asbestosis mortality across a pool of Italian occupational cohorts, taking into account the presence of competing risks.<br><br>METHODS: Cohorts were followed for vital status and the cause of death was ascertained by a linkage with mortality registers. Cause-specific (CS) Cox-regression models were used to evaluate the dose-exposure relationship between asbestosis mortality and the time-dependent cumulative exposure index (CEI) to asbestos. Fine and Gray regression models were computed to assess the effect of competing risks of death.<br><br>RESULTS: The cohort included 12,963 asbestos cement workers. During the follow-up period (1960-2012), of a total of 6961 deaths, we observed 416 deaths attributed to asbestosis, 879 to lung cancer, 400 to primary pleural cancer, 135 to peritoneal cancer, and 1825 to diseases of the circulatory system. The CS model showed a strong association between CEI and asbestosis mortality. Dose-response models estimated an increasing trend in mortality even below a CEI of 25 ff/mL-years. Lung cancer and circulatory diseases were the main competing causes of death.<br><br>CONCLUSIONS: Asbestos exposure among Italian asbestos-cement workers has led to a very high number of deaths from asbestosis and asbestos-related diseases. The increasing risk trend associated with excess deaths, even at low exposure levels, suggests that the proposed limit values would not have been adequate to prevent disability and mortality from asbestosis.},
}
@article {pmid38920665,
year = {2024},
author = {Zhand, S and Liao, J and Castorina, A and Yuen, ML and Ebrahimi Warkiani, M and Cheng, YY},
title = {Small Extracellular Vesicle-Derived Circular RNA hsa_circ_0007386 as a Biomarker for the Diagnosis of Pleural Mesothelioma.},
journal = {Cells},
volume = {13},
number = {12},
pages = {},
pmid = {38920665},
issn = {2073-4409},
support = {2023/24 ideas to action//NSW Dust Diseases board (iCare)/ ; },
mesh = {Humans ; *RNA, Circular/genetics/metabolism ; *Extracellular Vesicles/metabolism/genetics ; *Biomarkers, Tumor/genetics/metabolism ; *Mesothelioma/genetics/diagnosis ; Cell Line, Tumor ; Pleural Neoplasms/genetics/diagnosis ; Gene Expression Regulation, Neoplastic ; Mesothelioma, Malignant/genetics/diagnosis ; },
abstract = {Pleural mesothelioma (PM) is a highly aggressive tumor that is caused by asbestos exposure and lacks effective therapeutic regimens. Current procedures for PM diagnosis are invasive and can take a long time to reach a definitive result. Small extracellular vesicles (sEVs) have been identified as important communicators between tumor cells and their microenvironment via their cargo including circular RNAs (circRNAs). CircRNAs are thermodynamically stable, highly conserved, and have been found to be dysregulated in cancer. This study aimed to identify potential biomarkers for PM diagnosis by investigating the expression of specific circRNA gene pattern (hsa_circ_0007386) in cells and sEVs using digital polymerase chain reaction (dPCR). For this reason, 5 PM, 14 non-PM, and one normal mesothelial cell line were cultured. The sEV was isolated from the cells using the gold standard ultracentrifuge method. The RNA was extracted from both cells and sEVs, cDNA was synthesized, and dPCR was run. Results showed that hsa_circ_0007386 was significantly overexpressed in PM cell lines and sEVs compared to non-PM and normal mesothelial cell lines (p < 0.0001). The upregulation of hsa_circ_0007386 in PM highlights its potential as a diagnostic biomarker. This study underscores the importance and potential of circRNAs and sEVs as cancer diagnostic tools.},
}
@article {pmid38902063,
year = {2024},
author = {Couchman, E and Ejegi-Memeh, S and Mitchell, S and Gardiner, C},
title = {Rethinking continuity in primary care for people with mesothelioma.},
journal = {The British journal of general practice : the journal of the Royal College of General Practitioners},
volume = {74},
number = {suppl 1},
pages = {},
doi = {10.3399/bjgp24X737373},
pmid = {38902063},
issn = {1478-5242},
mesh = {Humans ; *Continuity of Patient Care ; *Primary Health Care ; *Mesothelioma/therapy ; Male ; Female ; State Medicine ; United Kingdom ; Middle Aged ; Qualitative Research ; Aged ; Lung Neoplasms/therapy ; Attitude of Health Personnel ; },
abstract = {BACKGROUND: Mesothelioma is a terminal disease that is linked to asbestos exposure. Continuity is difficult for GPs, and other healthcare professionals (HCPs), to provide within the current NHS primary care system, but is highly valued by people with mesothelioma.<br><br>AIM: To understand the experiences of continuity in primary care among people with mesothelioma, their close persons, and their HCPs; how they achieve this (or not); and how it affects their healthcare service use.<br><br>METHOD: Realist case studies of patient journeys through the healthcare system (involving longitudinal interviews with people with mesothelioma, their close persons, and HCPs; and exploration of the organisational context). Data analysis allowed understanding of hidden mechanisms (resources and reasoning), triggered in certain contexts, leading to specific outcomes.<br><br>RESULTS: Forty-eight interviews (involving 9 patients, 8 close persons, and 12 HCPs) were undertaken (totalling 30.8 hours/1848 minutes). Context-Mechanism-Outcome configurations related to: challenges unique to mesothelioma; capacity of patients/close persons/HCPs to facilitate continuity; multidisciplinary (MDT) approach differs from the family doctor model; and 'the NHS primary care system is broken'.<br><br>CONCLUSION: Patients perceive their continuity needs to be unmet by the inflexible primary care system, which needs to adapt to a society in which people receive increasingly novel treatments and live longer with complex healthcare needs. A societal perspective shift is required to understand that an MDT now shares responsibility for care, rather than an individual family doctor. Policy documents continue to focus on access, and still do not advocate strongly enough for continuity, despite unequivocal evidence demonstrating its worth.},
}
@article {pmid38891178,
year = {2024},
author = {Santos, C and Sacadura-Leite, E and Ferreira, J and Dixe, MDA and Astoul, P and Sousa-Uva, A},
title = {The Pleural Mesothelioma Cases and Mortality in Portugal in 2014-2020: A Descriptive Study.},
journal = {Healthcare (Basel, Switzerland)},
volume = {12},
number = {11},
pages = {},
pmid = {38891178},
issn = {2227-9032},
abstract = {BACKGROUND: The incidence and mortality of pleural mesothelioma (PM) reflect the production and consumption of asbestos over time. However, despite the current global concern, these data remain to be known.<br><br>OBJECTIVE: Our aim was to carry out a descriptive analysis of PM cases and mortality from some Portuguese databases between 2014 and 2020.<br><br>METHODS: A retrospective observational study was carried out between 2014 and 2020. Data on the number of PM cases were provided by the Portuguese Cancer Registry, and data on mortality were from the Portuguese Death Certificate Information System.<br><br>RESULTS: Between 2014 and 2020, 315 cases of PM were reported, with 222 (70.5%) men. The average age of patients was 72.1, with the highest number of cases in patients aged >70 years (n = 198; 62.9%). The highest number of cases was reported in 2018 (n = 62; 19.7%). Regarding mortality, 169 deaths were reported, with 126 (74.6%) men and mostly in individuals aged >70 years (n = 109; 64.5%). It is estimated that around 520 years of potential life were lost. The highest number of deaths occurred in 2015 (n = 33; 19.5%).<br><br>CONCLUSION: It is mandatory to reinforce the need for surveillance programs that allow us to gather real and reliable data and eliminate asbestos-related diseases.},
}
@article {pmid38886298,
year = {2024},
author = {Lin, RT and Boonhat, H and Lin, YY and Klebe, S and Takahashi, K},
title = {Health Effects of Occupational and Environmental Exposures to Nuclear Power Plants: A Meta-Analysis and Meta-Regression.},
journal = {Current environmental health reports},
volume = {11},
number = {3},
pages = {329-339},
pmid = {38886298},
issn = {2196-5412},
support = {CMU112-MF-76 and CMU111-MF-82//China Medical University, Taiwan/ ; 111-2314-B-039-020-MY2 and 110-2314-B-039-058//National Science and Technology Council, Taiwan/ ; },
mesh = {*Nuclear Power Plants ; Humans ; *Occupational Exposure/adverse effects/analysis ; *Radiation Exposure/adverse effects ; *Environmental Exposure/adverse effects ; Neoplasms, Radiation-Induced/epidemiology/etiology ; },
abstract = {PURPOSE OF REVIEW: Numerous epidemiological studies have shown increased health risks among workers and residents living near nuclear power plants exposed to radiation levels meeting regulatory dose limits. This study aimed to evaluate the association between radiation exposure and disease risks among these populations exposed to radiation levels meeting the current regulatory dose limits.<br><br>RECENT FINDINGS: We searched four databases (Cochrane Library, PubMed, ScienceDirect, and Web of Science) for studies published before August 2023, screened eligible studies (inclusion and exclusion criteria based on population, exposure, comparator, and outcome framework), and collected data on exposure indicators and disease risks. We applied random-effects models of meta-analysis to estimate the pooled effects and meta-regression to assess the dose-response relationship (radiation dose rate for workers and distance for residents). We identified 47 studies, 13 with worker and 34 with resident samples, covering 175 nuclear power plants from 17 countries, encompassing samples of 480,623 workers and 7,530,886 residents. Workers had a significantly lower risk for all-cancer and a significantly higher risk for mesothelioma. Residents had significantly higher risks for all-cancer, thyroid cancer, and leukemia. Notably, children under 5 years old showed the highest risk for all-cancer. Our meta-regression showed a significantly positive dose-response relationship between cumulative dose of radiation exposure and risk for circulatory disease among workers. Our findings demonstrated higher risks for mesothelioma for workers and all-cancer, thyroid cancer, and leukemia for residents exposed to low-dose radiation from nuclear power plants. Some included studies did not adjust for cancer risk confounders, which could overestimate the association between radiation exposure and cancer risk and increase the risk of bias.},
}
@article {pmid38880927,
year = {2024},
author = {Fu, F and Zhang, Y and Shen, H},
title = {[Advances in Targeted Therapy for Malignant Pleural Mesothelioma].},
journal = {Zhongguo fei ai za zhi = Chinese journal of lung cancer},
volume = {27},
number = {5},
pages = {391-398},
pmid = {38880927},
issn = {1999-6187},
mesh = {Humans ; *Mesothelioma, Malignant/drug therapy/therapy ; *Mesothelioma/drug therapy/therapy ; *Lung Neoplasms/drug therapy/therapy/genetics ; *Molecular Targeted Therapy ; Pleural Neoplasms/drug therapy/therapy ; Animals ; Endoplasmic Reticulum Chaperone BiP ; },
abstract = {Malignant pleural mesothelioma (MPM) is a rare cancer with high malignancy and aggressiveness on the pleural, caused by the following risk factors including asbestos inhalation, genetic factors, and genetic mutation. The present chemotherapy, antiangiogenic therapy, and immunotherapy methods are ineffective and the survival time of patients is very short. There is an urgent need to find potential therapeutic targets for MPM. At present, it has been found the following types of targets: gene mutation targets such as BRCA associated protein 1 (BAP1) and cyclin-dependent kinase 2A (CDKN2A); epigenetic targets such as lysine (K)-specific demethylase 4A (KDM4A) and lysine-specific demethylase 1 (LSD1), and signal protein targets such as glucose-regulated protein 78 (GRP78) and signal transducer and activator of transcription 3 (STAT3). So far, available clinical trials include phase II clinical trials of histone methyltransferase inhibitor Tazemetostat, poly (ADP-ribose) polymerase (PARP) inhibitor Rucaparib and cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor Abemaciclib, as well as phase I clinical trials of mesothelin-targeting chimeric antigen receptor T-cell immunotherapy (CAR-T) cell injection in the thoracic cavity and TEA domain family member (TEAD) inhibitor VT3989 and IK-930, and the results of these trials have showed certain clinical efficacy. .},
}
@article {pmid38858710,
year = {2024},
author = {Huh, DA and Choi, YH and Kim, L and Park, K and Lee, J and Hwang, SH and Moon, KW and Kang, MS and Lee, YJ},
title = {Air pollution and survival in patients with malignant mesothelioma and asbestos-related lung cancer: a follow-up study of 1591 patients in South Korea.},
journal = {Environmental health : a global access science source},
volume = {23},
number = {1},
pages = {56},
pmid = {38858710},
issn = {1476-069X},
mesh = {Humans ; Male ; Republic of Korea/epidemiology ; *Lung Neoplasms/mortality ; Female ; Aged ; Middle Aged ; *Mesothelioma, Malignant/mortality ; *Air Pollutants/adverse effects/analysis ; Follow-Up Studies ; *Air Pollution/adverse effects ; Asbestos/adverse effects ; Environmental Exposure/adverse effects ; Particulate Matter/adverse effects/analysis ; Aged, 80 and over ; Adult ; Mesothelioma/mortality/epidemiology ; },
abstract = {BACKGROUND: Despite significant advancements in treatments such as surgery, radiotherapy, and chemotherapy, the survival rate for patients with asbestos-related cancers remains low. Numerous studies have provided evidence suggesting that air pollution induces oxidative stress and inflammation, affecting acute respiratory diseases, lung cancer, and overall mortality. However, because of the high case fatality rate, there is limited knowledge regarding the effects of air pollution exposures on survival following a diagnosis of asbestos-related cancers. This study aimed to determine the effect of air pollution on the survival of patients with malignant mesothelioma and asbestos-related lung cancer.<br><br>METHODS: We followed up with 593 patients with malignant mesothelioma and 998 patients with lung cancer identified as asbestos victims between 2009 and 2022. Data on five air pollutants-sulfur dioxide, carbon monoxide, nitrogen dioxide, fine particulate matter with a diameter&#x2009;<&#x2009;10&#xa0;&#x3bc;m, and fine particulate matter with a diameter&#x2009;<&#x2009;2.5&#xa0;&#x3bc;m-were obtained from nationwide atmospheric monitoring stations. Cox proportional hazard models were used to estimate the association of cumulative air pollutant exposure with patient mortality, while adjusting for potential confounders. Quantile-based g-computation was used to assess the combined effect of the air pollutant mixture on mortality.<br><br>RESULTS: The 1-, 3-, and 5-year survival rates for both cancer types decreased with increasing exposure to all air pollutants. The estimated hazard ratios rose significantly with a 1-standard deviation increase in each pollutant exposure level. A quartile increase in the pollutant mixture was associated with a 1.99-fold increase in the risk of malignant mesothelioma-related mortality (95% confidence interval: 1.62, 2.44). For lung cancer, a quartile increase in the pollutant mixture triggered a 1.87-fold increase in the mortality risk (95% confidence interval: 1.53, 2.30).<br><br>CONCLUSION: These findings support the hypothesis that air pollution exposure after an asbestos-related cancer diagnosis can negatively affect patient survival.},
}
@article {pmid38857841,
year = {2024},
author = {Chornkrathok, S and Carbone, M and Yang, H and Rouf, M and Dodson, RF and Dera, P},
title = {Mineralogical investigation of asbestos contamination of soil near old vermiculite processing plant in Honolulu, Hawai'i.},
journal = {Environmental pollution (Barking, Essex : 1987)},
volume = {356},
number = {},
pages = {124350},
doi = {10.1016/j.envpol.2024.124350},
pmid = {38857841},
issn = {1873-6424},
mesh = {*Aluminum Silicates ; Hawaii ; *Soil Pollutants/analysis ; *Asbestos/analysis ; *Environmental Monitoring ; *Mining ; *Soil/chemistry ; Asbestos, Amphibole ; },
abstract = {From 1954 to 1983, a vermiculite processing facility operated near the Honolulu airport and processed raw material from the Libby, Montana mine, which is now well known for the high asbestos content of its clay deposits. The factory was closed in 1983 due to health hazard concerns, and remediation was performed in 2001 as part of the Libby mine superfund project. However, because of close proximity of the closed-down facility to residential areas of metropolitan Honolulu, some concerns remain regarding the possible environmental persistence of the harmful contaminant. To assess the dispersion of asbestos-contaminated vermiculite and explore the impact of trade winds on its distribution, air samples, and soil samples were collected from multiple locations near the former vermiculite plant. Polarized light microscopy was employed to identify elongated minerals, including potential asbestos. Quantitative mineralogical analysis utilizing X-ray powder diffraction and Rietveld refinement revealed an average content of approximately 7% vermiculite and 4% tremolite at the site. The asbestiform nature of tremolite was confirmed through X-ray micro-diffraction. Detailed analysis of airborne samples using transmission electron microscopy revealed no detectable levels of asbestos fibers in the vicinity of the former processing facilities, but the possibility of asbestos fibers becoming airborne due to mechanical disturbance during dry weather cannot be ruled out.},
}
@article {pmid38854177,
year = {2024},
author = {Potesta, MA and Guld, E and Laman, J},
title = {Dual Malignancies Discovered: A Rare Case of Malignant Peritoneal Epithelioid Mesothelioma and Lung Adenocarcinoma.},
journal = {Cureus},
volume = {16},
number = {5},
pages = {e59962},
pmid = {38854177},
issn = {2168-8184},
abstract = {Clinicians diagnosing malignant peritoneal epithelioid mesothelioma (MPM or MPeM) have historically had challenges due to the low incidence of the disease, as well as the often vague symptomatology that patients present with. Newer advances in technology, specifically in immunocytochemistry, have provided a clearer path to diagnosis. Additionally, malignant mesotheliomas must be differentiated from carcinomas. This is done via histology, immunocytochemistry, as well as a careful incorporation of the patient's clinical history. In this case, we present an asymptomatic 73-year-old non-smoker female with no past medical history of asbestos exposure. She was diagnosed with MPM following a routine abdominal hernia repair. Subsequent workup revealed a lung infiltrate that was successfully biopsied and resected, evidently found to be adenocarcinoma. A careful review of the resulting pathology, as well as the interpretation of immunocytochemistry, supported the notion that the patient had two independent malignant processes occurring at once. This case underscores the rarity of two similar, yet distinct cancers, as well as epidemiology, symptomatology, histology, immunocytochemistry, and prognosis.},
}
@article {pmid38806867,
year = {2024},
author = {Chen, Z and Cai, Y and Ou, T and Zhou, H and Li, H and Wang, Z and Cai, K},
title = {Global burden of mesothelioma attributable to occupational asbestos exposure in 204 countries and territories: 1990-2019.},
journal = {Journal of cancer research and clinical oncology},
volume = {150},
number = {5},
pages = {282},
pmid = {38806867},
issn = {1432-1335},
support = {2022A028//the Dean Research Funding of Nanfang Hospital, Southern Medical University, China/ ; },
mesh = {Humans ; *Occupational Exposure/adverse effects ; *Asbestos/adverse effects ; Male ; Female ; *Global Burden of Disease ; Middle Aged ; Aged ; Adult ; Mesothelioma/epidemiology/mortality/etiology ; Mesothelioma, Malignant/epidemiology/mortality/etiology ; Disability-Adjusted Life Years ; Lung Neoplasms/epidemiology/etiology/mortality ; Aged, 80 and over ; Global Health/statistics &amp; numerical data ; Occupational Diseases/epidemiology/mortality/etiology ; },
abstract = {Malignant mesothelioma, a rare and aggressive cancer primarily caused by occupational asbestos exposure, has a poor prognosis. This study leverages the Global Burden of Disease (GBD) 2019 dataset to analyze the burden of mesothelioma linked to occupational asbestos exposure from 1990 to 2019. The analysis includes the number of mesothelioma deaths and disability-adjusted life years (DALYs) attributable to occupational asbestos exposure, focusing on trends in age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life-year rate (ASDR) by year, age, sex, country, region, and Socio-demographic Index (SDI). In 2019, 91.7% of mesothelioma deaths and 85.2% of DALYs were attributable to occupational asbestos exposure, resulting in 26,820 (95% UI 24,312-28,622) deaths and 569,429 (95% UI 509,956-617,484) DALYs. Despite a decline in ASMR and ASDR from 1990 to 2019, the absolute number of deaths and DALYs almost doubled. The United States reported the highest number of mesothelioma deaths, while China had the highest number of DALYs. Age-specific mortality rates and DALYs decreased in the 25-74 age group but increased in the 75+ age group. In conclusion, occupational asbestos exposure remains the primary cause of mesothelioma worldwide, with an increasing number of deaths and DALYs. The highest incidence rates are observed in high-income areas, and rates are rising in low-income areas. It is crucial to raise awareness about the hazards of asbestos to reduce the global burden of mesothelioma linked to occupational exposure.},
}
@article {pmid38806807,
year = {2024},
author = {Albano, GD and Rodolico, V and Di Franco, S and Re, GL and Midiri, M and Malta, G and Cannizzaro, E and Argo, A and Zerbo, S},
title = {Asbestos exposure determined 357 days after death through autopsy: a report of a multidisciplinary approach.},
journal = {Forensic science, medicine, and pathology},
volume = {},
number = {},
pages = {},
pmid = {38806807},
issn = {1556-2891},
abstract = {Asbestosis is an interstitial lung disease caused by the inhalation of asbestos fibers and poses a significant risk to individuals working in construction, shipping, mining, and related industries. In a forensic context, postmortem investigations are crucial for accurate diagnosis, for which the gold standard is the histopathological examination. This case report describes the autopsy and related investigations conducted on an 84-year-old man, nearly one year (357 days) after his death. After a post-mortem CT scan, an autoptic investigation was performed, followed by histopathological, immunohistochemical, and scanning electron microscopy examinations. The integration of the evidence from these examinations with previously available personal and clinical information conclusively confirmed the diagnosis of asbestosis. We demonstrated the efficacy and reliability of our diagnostic protocol in detecting asbestosis and asbestos fibers and excluding mesothelioma even in decomposed tissues. According to our findings autopsy remains the diagnostic gold standard in cases of suspected asbestosis within a forensic context, even 1 year after death, therefore it is always highly recommended, even in cases where the body has decomposed.},
}
@article {pmid38806763,
year = {2024},
author = {Yaşar, S and Yılmaz, F and Utkan, G and Algın, E and Bayram, D and Tamam, S and Öksüzoğlu, &#xd6;B&#xc7; and İlhan, A and Erdat, EC and Ünal, AE and Yalçın, &#x15e;},
title = {Analysis of Treatment Strategies and Outcomes in Malignant Peritoneal Mesothelioma: Insights From a Multi-Center Study.},
journal = {Annals of surgical oncology},
volume = {31},
number = {9},
pages = {6228-6236},
pmid = {38806763},
issn = {1534-4681},
mesh = {Humans ; *Peritoneal Neoplasms/therapy/secondary/mortality ; Female ; Male ; Middle Aged ; Retrospective Studies ; *Cytoreduction Surgical Procedures ; *Mesothelioma, Malignant/therapy/pathology ; Survival Rate ; Prognosis ; Aged ; Follow-Up Studies ; *Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; *Hyperthermic Intraperitoneal Chemotherapy ; Adult ; Combined Modality Therapy ; Lung Neoplasms/therapy/pathology/mortality ; },
abstract = {BACKGROUND: This study aimed to evaluate the demographic," clinicopathologic, and prognostic characteristics of malignant peritoneal mesothelioma (MPeM), as well as the treatment options for the rare and heterogeneous MPeM population.<br><br>METHODS: A retrospective multi-center observational cohort study was conducted to evaluate patients with MPeM. Due to the heterogeneity of the study population, the study divided them into two main groups in terms of treatments, follow-up periods, and prognostic features. The first group comprised the patients who underwent cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), and the second group included the patients with metastatic disease for whom curative intent surgery was not possible. The patients' diagnostic procedures and treatments were identified from medical records. Patients older than 18 years old were included in the study regardless of asbestos exposure. Well-differentiated papillary and multicystic mesothelioma histologic types were not included in the study.<br><br>RESULTS: The study evaluated 118 patients from five centers. Survival times, prognosis, and treatment responses were analyzed in both groups. The study showed that CRS-HIPEC was associated with longer overall survival (OS) and progression-free survival (PFS). Perioperative therapy was evaluated in subgroup analyses of this population and shown to provide survival benefits. The patients treated with chemotherapy (metastatic and medically inoperable patients and those for whom complete cytoreduction was not achievable) had a poorer prognosis than the surgery group. The study showed that life expectancy decreased significantly for the patients not suitable to undergo surgery for any reason.<br><br>CONCLUSIONS: According to data from experienced centers, CRS-HIPEC is a treatment option recognized as effective, cost-effective, and safe, with better OS and PFS , as well as low morbidity and mortality rates similar to those in the literature. In addition, the platinum-pemetrexed combination continues to be an effective and acceptable treatment option for metastatic patients, those who are medically inoperable, and those for whom complete or near-complete cytoreduction is not achievable.},
}
@article {pmid38803090,
year = {2024},
author = {Altshuler, PC and Newman, AL and Garibay, JA},
title = {Rapid Progression of Malignant Peritoneal Mesothelioma Mimicking a Postoperative Complication in a Young Woman: A Case Report.},
journal = {The American journal of case reports},
volume = {25},
number = {},
pages = {e942948},
pmid = {38803090},
issn = {1941-5923},
mesh = {Humans ; Female ; Adult ; *Peritoneal Neoplasms/diagnosis ; *Postoperative Complications/diagnosis ; *Ovarian Neoplasms/diagnosis/pathology ; *Mesothelioma, Malignant/diagnosis ; Fatal Outcome ; Diagnosis, Differential ; Disease Progression ; Teratoma/diagnosis/surgery ; Salpingo-oophorectomy ; Mesothelioma/diagnosis ; },
abstract = {BACKGROUND Malignant peritoneal mesothelioma is a rare disease with a poor prognosis that often presents with vague symptoms and inconclusive laboratory test results. Causes include industrial pollutants, primarily asbestos, and certain genetic mutations, such as BAP1. Due to the nonspecific symptoms, it is often incidentally diagnosed during or after other surgical procedures. CASE REPORT A 35-year-old healthy woman underwent an uncomplicated laparoscopic left salpingo-oophorectomy for a symptomatic large ovarian mature cystic teratoma. She subsequently presented with late-onset postoperative fever, leukocytosis, and multiple intra-abdominal masses. Following an exploratory laparotomy, extensive infectious disease evaluation, and multiple biopsies requiring interdisciplinary collaboration, malignant peritoneal mesothelioma was diagnosed by positive histologic staining of an omental biopsy for D2-40 and CK5/6. This first specimen was positive for BAP1, with the second, a liver biopsy, testing negative for BAP1. The tumor cell testing was also notable for mutations in NF2, MLL2, and ARID1A, and the hereditary cancer genetic testing was overall unremarkable. Her disease progressed rapidly, and she died 6 months after her initial procedure. CONCLUSIONS This case of rapidly developing malignant peritoneal mesothelioma following surgical management of an ovarian mature teratoma highlights the complexity in diagnosing a rare disease that presents with nonspecific symptoms in an otherwise young and healthy woman. The rapid disease course was likely accelerated by expansive intraperitoneal spread and multiple somatic oncogenic mutations in BAP1, NF2, MLL2, and ARID1A. Gynecologists should keep a broad differential for postoperative complications, as occult malignancies can present with symptoms that mimic postoperative complications.},
}
@article {pmid38798778,
year = {2024},
author = {Singh, R and Frank, AL},
title = {Analysis of mesothelioma cases and National Cancer Registry data to assess asbestos exposure in India.},
journal = {Public health action},
volume = {14},
number = {1},
pages = {30-33},
pmid = {38798778},
issn = {2220-8372},
abstract = {SETTING: Asbestos exposure can cause mesothelioma, a form of cancer which should be recorded by cancer registries. However, such registries currently cover only a small fraction (16%) of the population in India. Because India still uses asbestos, it is important to understand its health impact, especially the number of mesothelioma cases.<br><br>OBJECTIVE: To assess the number of mesothelioma cases in India and compare these to the number reported to the National Cancer Registry.<br><br>DESIGN: We used the Right to Information Act 2005 to gather data for 83 hospitals across India from 2012 to 2022-2023.<br><br>RESULTS: From a total of 83 hospitals, there were 2,213 cases of mesothelioma from 2012 onwards. During the 2012-2016 period, the number of reported cases in the Cancer Registry was 54, whereas 1,126 cases were reported by these hospitals for this period. Only 21 (25%) of the hospitals assessed in this study were part of the population-based national cancer registry programme. Overall, cases of mesothelioma occur far more frequently than are reported in cancer registries.<br><br>CONCLUSION: National record-keeping is inadequate and the system needs to be expanded and improved across all of India. This will provide more effective reporting and help to highlight the risk of exposure to asbestos.},
}
@article {pmid38791896,
year = {2024},
author = {Hintermair, S and Iser, S and Varga, A and Biesinger, M and Bohanes, T and Celik, A and Sayan, M and Kankoç, A and Akyurek, N and Öğüt, B and Stubenberger, E and Ghanim, B},
title = {Ki67 Tumor Expression Predicts Treatment Benefit Achieved by Macroscopic Radical Lung-Preserving Surgery in Pleural Mesothelioma-A Retrospective Multicenter Analysis.},
journal = {Cancers},
volume = {16},
number = {10},
pages = {},
pmid = {38791896},
issn = {2072-6694},
abstract = {Pleural mesothelioma (PM), linked to asbestos-induced inflammation, carries a poor prognosis. Therapy ranges from therapy limitation to aggressive multimodality treatment. Given the uncertainty about treatment benefits for patients, this study aimed to assess the role of Ki67 as a prognostic and predictive parameter in PM. Ki67 was measured in the specimens of 70 PM patients (17 female, 53 male) from two centers and correlated to overall survival (OS) and therapy outcome. The median OS was 16.1 months. The level of Ki67 expression was divided into low (≤15%) and high (>15%). A low value of Ki67 expression was associated with a longer OS (Ki67 ≤ 15%: 31.2 (95% CI 6.5-55.8) months vs. Ki67 > 15%: 11.1 (95% CI 7.7-14.6) months, p = 0.012). The 5-year survival represents 22% in the low Ki67 expression group, in contrast to 5% in the high Ki67 expression group. We found a significant interaction term of Ki67 with multimodality treatment (p = 0.031) translating to an OS of 48.1 months in the low expression Ki67 group compared to 24.3 months in the high Ki67 expression group when receiving surgery within multimodality therapy. Therefore, Ki67 stands out as a validated prognostic and, most importantly, novel predictive biomarker for treatment benefits, particularly regarding surgery within multimodality therapy.},
}
@article {pmid38789301,
year = {2024},
author = {Hassan, A and Prabhakaran, S and Pulford, E and Hocking, AJ and Godbolt, D and Ziad, F and Pandita, A and Wessels, A and Hussey, M and Russell, PA and Klebe, S},
title = {The significance of BAP1 and MTAP/CDKN2A expression in well-differentiated papillary mesothelial tumour: a series of 21 cases and a review of the literature.},
journal = {Pathology},
volume = {56},
number = {5},
pages = {662-670},
doi = {10.1016/j.pathol.2024.02.016},
pmid = {38789301},
issn = {1465-3931},
mesh = {Humans ; *Ubiquitin Thiolesterase/metabolism ; *Tumor Suppressor Proteins/metabolism ; Male ; Female ; Middle Aged ; Aged ; Adult ; *Cyclin-Dependent Kinase Inhibitor p16/metabolism ; *Mesothelioma/pathology/metabolism/diagnosis ; *Biomarkers, Tumor/metabolism/analysis ; Purine-Nucleoside Phosphorylase/metabolism ; Young Adult ; Mesothelioma, Malignant/pathology/diagnosis/metabolism ; Neoplasms, Mesothelial/pathology/metabolism/diagnosis ; Lung Neoplasms/pathology/metabolism/diagnosis ; Pleural Neoplasms/pathology/metabolism/diagnosis ; Immunohistochemistry ; },
abstract = {The nomenclature and diagnostic criteria of well-differentiated papillary mesothelial tumour (WDPMT) have been changed in the 2021 World Health Organization (WHO) classification of thoracic tumours, and a new entity, mesothelioma in situ (MIS), introduced. Histologically these two entities may be similar. However, MIS is regarded as a precursor to invasive mesothelioma and requires demonstration of loss of BAP1 and/or MTAP/CDKN2A for diagnosis, whereas performance of these ancillary tests is desirable but not essential for a diagnosis of WDPMT, in which the significance of BAP1 and/or MTAP/CDKN2A loss is not well understood or well defined. Against this backdrop, we undertook an investigation of 21 cases of WDPMT, identified from our case files and diagnosed according to 2021 WHO criteria, to explore the relationship between histology and BAP1 and MTAP/CDKN2A expression with clinical features including asbestos exposure, focality of tumours and clinical outcome. There were 18 women and three men, with ages ranging from 23-77 years (median 62 years), in which six had a history of asbestos exposure, two had no exposure, and in 13 exposure history was unavailable. Of 20 peritoneal tumours and one pleural tumour, 13 were detected incidentally at the time of surgery for unrelated conditions and eight peritoneal tumours were multifocal at the time of diagnosis. BAP1 immunohistochemistry (IHC) was performed in all 21 tumours, with nine tumours showing BAP1 expression loss. MTAP/CDKN2A testing was performed in 14 tumours, comprising MTAP IHC in 12 and CDKN2A fluorescence in situ hybridisation (FISH) in two, with three tumours showing MTAP/CDKN2A expression loss. Two tumours with MTAP/CDKN2A loss also showed BAP1 expression loss. Four patients progressed to invasive mesothelioma, including one male with a pleural tumour and asbestos exposure, and three females with multifocal peritoneal tumours, two with asbestos exposure and one without exposure. BAP1 expression loss was seen in all tumours from the four patients who progressed to invasive mesothelioma, whilst two of these tumours showed retained MTAP IHC and two were not tested. There was one patient with a tumour with MTAP loss and retained BAP1 who died from unrelated causes 5 months after diagnosis. Eight patients received WDPMT-specific treatment in addition to the initial excision. Survival for all patients ranged from 4-218 months, with one patient dying of mesothelioma at 49 months. Based on our results in this series of 21 patients with WDPMT diagnosed according to 2021 WHO criteria, we propose that WDPMT with BAP1 expression loss may best be regarded as papillary MIS and that a history of asbestos exposure and the presence of multifocal tumours in patients diagnosed with WDPMT should prompt ancillary testing with BAP1 IHC. Further we propose that BAP1 IHC should be essential in the diagnosis of WDPMT, with the diagnosis restricted to those tumours which show retained BAP1 expression. However more studies in larger cohorts of patients are needed to explore the relationship between BAP1 expression and MTAP loss in WDPMT, which will help to define this entity and separate it more clearly from MIS and invasive mesothelioma.},
}
@article {pmid38784478,
year = {2024},
author = {Testa, JR and Kadariya, Y and Friedberg, JS},
title = {Targeting inflammatory factors for chemoprevention and cancer interception to tackle malignant mesothelioma.},
journal = {Oncoscience},
volume = {11},
number = {},
pages = {53-57},
pmid = {38784478},
issn = {2331-4737},
abstract = {Mesothelioma is an incurable cancer of the mesothelial lining often caused by exposure to asbestos. Asbestos-induced inflammation is a significant contributing factor in the development of mesothelioma, and genetic factors also play a role in the susceptibility to this rapidly progressive and treatment-resistant malignancy. Consequently, novel approaches are urgently needed to treat mesothelioma and prevent or reduce the overall incidence of this fatal disease. In this research perspective, we review the current state of chemoprevention and cancer interception progress in asbestos-induced mesothelioma. We discuss the different preclinical mouse models used for these investigations and the inflammatory factors that may be potential targets for mesothelioma prevention. Preliminary studies with naturally occurring phytochemicals and synthetic agents are reviewed. Results of previous clinical chemoprevention trials in populations exposed to asbestos and considerations regarding future trials are also presented.},
}
@article {pmid38781764,
year = {2024},
author = {Broggi, G and Massimino, M and Failla, M and Filetti, V and Rapisarda, V and Ledda, C and Lombardo, C and Loreto, C and Vigneri, P and Caltabiano, R},
title = {Concordance between CDKN2A homozygous deletion and MTAP immunohistochemical loss in fluoroedenite-induced pleural mesothelioma: An immunohistochemical and molecular study on a single-institution series.},
journal = {Pathology, research and practice},
volume = {259},
number = {},
pages = {155350},
doi = {10.1016/j.prp.2024.155350},
pmid = {38781764},
issn = {1618-0631},
mesh = {Aged ; Female ; Humans ; Male ; Middle Aged ; Asbestos, Amphibole ; Biomarkers, Tumor/genetics/analysis/metabolism ; *Cyclin-Dependent Kinase Inhibitor p16/genetics/metabolism ; Gene Deletion ; Homozygote ; *Immunohistochemistry ; *Mesothelioma/genetics/pathology/chemically induced/metabolism ; Mesothelioma, Malignant/pathology/genetics ; *Pleural Neoplasms/genetics/pathology/chemically induced/metabolism ; Purine-Nucleoside Phosphorylase/genetics ; },
abstract = {Fluoroedenite-induced pleural mesothelioma (FE-induced-PM) is a rare and small subset of PM that shares with its asbestos-induced counterpart the same aggressive biological behavior and poor prognosis, but that differs from it from a pathogenetic point of view as it is associated with exposure to fluoroedenite, a carcinogenic agent that shows similarities with tremolite amphibolic asbestos fibers. Although it has been demonstrated that asbestos-induced PMs frequently harbor CDKN2A homozygous deletion and that the immunohistochemical loss of MTAP may represent a cheap and reliable surrogate marker for this molecular alteration, little is known about the molecular landscape and the reliability of MTAP immunohistochemistry in this peculiar subset of PM. The study herein presented investigated the prevalence of CDKN2A homozygous deletion and its concordance with MTAP immunohistochemical status on a cohort of 10 cases of FE-induced-PM from patients with environmental exposure to FE fibers, who were residents in the small town of Biancavilla (Sicily, Italy) or nearby areas. CDKN2A homozygous deletions were found in 3 out of 10 cases (30%) and all these cases showed concomitant cytoplasmic loss of MTAP with a concordance rate of 100%. Despite the relatively low number of cases included in our series, MTAP immunohistochemistry seemed to represent a reliable immunohistochemical surrogate marker of CDKNA homozygous deletion even in this subset of PMs.},
}
@article {pmid38763755,
year = {2024},
author = {Takata, A and Yamauchi, H and Yamashita, K and Aminaka, M and Hitomi, T and Toya, T and Kohyama, N},
title = {Mesothelioma carcinogenesis of chrysotile and forsterite compared and validated by intraperitoneal injection in rat.},
journal = {Industrial health},
volume = {},
number = {},
pages = {},
doi = {10.2486/indhealth.2024-0025},
pmid = {38763755},
issn = {1880-8026},
abstract = {Asbestos, especially chrysotile, continues to be exposed to humans globally. Hence, it should be disposed properly to prevent asbestos-related diseases, including mesothelioma and lung cancer. This study aimed to verify whether forsterite, a heating product of chrysotile, can cause carcinogenicity, particularly mesothelioma. Forsterite (FO-1000) and enstatite (EN-1500) produced by heating chrysotile at 1000°C and 1500°C, respectively, were subjected. We injected 10 mg of chrysotile, FO-1000, or EN-1500 in rats intraperitoneally and observed the development of peritoneal mesothelioma until 24 months. The incidence of peritoneal mesothelioma in the chrysotile group was 91.2%, whereas in the FO-1000 and EN-1500 groups, peritoneal mesothelioma did not develop. Urinary 8-hydroxy-2'-deoxyguanosine and serum N-ERC/mesothelin concentrations significantly increased in the chrysotile group that developed peritoneal mesothelioma, while they only temporarily changed in the FO-1000 or EN-1500 groups during early treatment. Furthermore, there was a significant homozygous deletion of the CDKN2A/p16 gene in the chrysotile group compared to the control group, in contrast to no significant difference in the FO-1000 and EN-1500 groups. Therefore, this study provides clear evidence that forsterite is a nonmesothelioma carcinogen and suggests that forsterite and enstatite are sufficient substances for chrysotile detoxification.},
}
@article {pmid38737188,
year = {2024},
author = {Hong Lee, AH and Macalister, SJ and Yap, KK},
title = {Pleural small cell lung cancer masquerading as malignant mesothelioma: A case report.},
journal = {Radiology case reports},
volume = {19},
number = {8},
pages = {2969-2972},
pmid = {38737188},
issn = {1930-0433},
abstract = {Nodular soft tissue pleural thickening on imaging is highly suggestive of malignancy, of which pleural malignant mesothelioma and metastatic disease are differentials. We present the case of a 71-year-old male who presented with acute worsening of shortness of breath associated with a recurrent left pleural effusion post-pleurocentesis. He was an ex-smoker with previous asbestos exposure. Computed tomography performed demonstrated left-sided pleural thickening in the hemithorax and hemidiaphragm with complex pleural effusion. [18]F-2-deoxy-d-glucose whole body PET scan revealed extensive uptake throughout the left hemithorax in multiple pleural masses. The imaging findings and clinical case were typical of malignant mesothelioma. However, histopathology results revealed small cell lung cancer. We need to be cognisant of this atypical presentation of a common disease entity. Even when all clinical and imaging findings point towards a certain diagnosis, histopathological assessment cannot be ignored.},
}
@article {pmid38736489,
year = {2024},
author = {Lapidot, M and Mazzola, E and Bueno, R},
title = {Prolonged survival and novel prognostic factors in women with pleural mesothelioma treated with extended pleurectomy decortication.},
journal = {Translational lung cancer research},
volume = {13},
number = {4},
pages = {811-820},
pmid = {38736489},
issn = {2218-6751},
abstract = {BACKGROUND: Pleural mesothelioma (PM) is an uncommon and extremely aggressive malignancy associated with past exposure to asbestos. The low representation of women among PM patients is likely due to differences in occupational asbestos exposure. Due to the controversial role of female sex as a prognostic factor in PM, the study aims to evaluate the survival of females treated with lung-sparing surgery. We present a cohort of 114 consecutive female patients with PM who underwent intended extended pleurectomy decortication (ePD) over 11 years in a high-volume single institution.<br><br>METHODS: All women from 2007-2017 who underwent intended ePD were enrolled in the study. Data on clinical, operative, and outcome were collected. Kaplan-Meier estimators and log-rank tests were employed to assess the overall survival, and Cox regression models were utilized to analyze prognostic factors.<br><br>RESULTS: During the study period, 454 patients underwent thoracotomy with intended ePD in a single institution. There were 114 females (25%), and macroscopic complete resection (MCR) was achieved in 97 (85.1%). The median age was 65 years, histology was epithelioid in 81 (71.0%), biphasic in 31 (27.2%), and sarcomatoid in 2 (1.8%). The 30- and 90-day mortality were 3.5% and 6.1%, respectively. Median survival in females was 38 months, and 5-year survival was 28.2%. The median survival and 5-year survival rate for patients with epithelioid histology and MCR were 44.4 months and 36.4%, respectively. In a univariate analysis, several factors were found to be associated with patient overall survival including MCR [hazard ratio (HR): 0.3, P<0.001], early T status (HR: 1.6, P=0.03), adjuvant therapy (HR: 0.5, P=0.006), intraoperative heated chemotherapy (IOHC) (HR: 0.8, P=0.03), age (HR: 1.02, P=0.03) and epithelioid histology (HR: 0.5, P=0.009).<br><br>CONCLUSIONS: For women with epithelioid PM undergoing intended ePD within a multimodal setting, prolonged survival is anticipated.},
}
@article {pmid38734073,
year = {2024},
author = {Bille, A and Ripley, RT and Giroux, DJ and Gill, RR and Kindler, HL and Nowak, AK and Opitz, I and Pass, HI and Wolf, A and Rice, D and Rusch, VW and , },
title = {The International Association for the Study of Lung Cancer Mesothelioma Staging Project: Proposals for the "N" Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Pleural Mesothelioma.},
journal = {Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
volume = {19},
number = {9},
pages = {1326-1338},
pmid = {38734073},
issn = {1556-1380},
support = {P30 CA008748/CA/NCI NIH HHS/United States ; },
mesh = {Humans ; *Neoplasm Staging/standards ; *Pleural Neoplasms/pathology/classification ; *Lung Neoplasms/pathology/classification/surgery/mortality ; *Mesothelioma/pathology/classification/mortality/surgery ; Male ; Female ; Mesothelioma, Malignant/pathology/classification/mortality ; Aged ; Middle Aged ; },
abstract = {INTRODUCTION: The International Association for the Study of Lung Cancer developed an international database to inform potential revisions in the ninth edition of the TNM classification of diffuse pleural mesothelioma (PM). This study analyzed the clinical and pathologic N categories to determine whether revisions were indicated relative to the eighth edition staging system.<br><br>METHODS: Of 7338 PM cases diagnosed from 2013 to 2022 and 3598 met&#xa0;all inclusion criteria for planned analyses. Data on 2836 patients without metastases were included in this study. Overall survival (OS) was measured from date of diagnosis. Patients were included regardless of whether they received neoadjuvant treatment. For the pathologic N analysis, patients who underwent resection (extrapleural pneumonectomy or pleurectomy/decortication) were included. N subgroups were analyzed and OS assessed by the Kaplan-Meier method.<br><br>RESULTS: The existing eighth edition N categories were performed adequately in the ninth edition data set. A median OS advantage was noted for clinical and pathologic N0 versus N1 patients: 23.2 versus 18.5 and 33.8 versus 25.0 months, respectively. Patients with resected pN0 had a 3-year OS of 48%. No difference in OS was noted for single- versus multiple-station nodal metastases. The number of nodal stations sampled at the time of resection was not associated with a difference in OS.<br><br>CONCLUSIONS: Data regarding clinical and pathologic N categories corroborate those used in the eighth edition. No changes in the N categories are recommended in the ninth edition of PM staging system.},
}
@article {pmid38729555,
year = {2024},
author = {Gugnoni, M and Lorenzini, E and Torricelli, F and Donati, B and Manicardi, V and Vitale, E and Muccioli, S and Piana, S and Lococo, F and Zamponi, R and Gandellini, P and Ciarrocchi, A},
title = {Linc00941 fuels ribogenesis and protein synthesis by supporting robust cMYC translation in malignant pleural mesothelioma.},
journal = {Cancer letters},
volume = {592},
number = {},
pages = {216950},
doi = {10.1016/j.canlet.2024.216950},
pmid = {38729555},
issn = {1872-7980},
mesh = {Humans ; *Mesothelioma, Malignant/genetics/pathology/metabolism ; *RNA, Long Noncoding/genetics/metabolism ; *Protein Biosynthesis ; *Eukaryotic Initiation Factor-4G/genetics/metabolism ; *Mesothelioma/genetics/pathology/metabolism ; Cell Line, Tumor ; *Proto-Oncogene Proteins c-myc/genetics/metabolism ; *Lung Neoplasms/genetics/pathology/metabolism ; *Gene Expression Regulation, Neoplastic ; Pleural Neoplasms/genetics/pathology/metabolism ; Ribosomes/metabolism/genetics ; Retrospective Studies ; Prognosis ; Cell Proliferation ; },
abstract = {Malignant pleural mesothelioma is a rare and lethal cancer caused by exposure to asbestos. The highly inflammatory environment caused by fibers accumulation forces cells to undergo profound adaptation to gain survival advantages. Prioritizing the synthesis of essential transcripts is an efficient mechanism coordinated by multiple molecules, including long non-coding RNAs. Enhancing the knowledge about these mechanisms is an essential weapon in combating mesothelioma. Linc00941 correlates to bad prognosis in various cancers, but it is reported to partake in distinct and apparently irreconcilable processes. In this work, we report that linc00941 supports the survival and aggressiveness of mesothelioma cells by influencing protein synthesis and ribosome biogenesis. Linc00941 binds to the translation initiation factor eIF4G, promoting the selective protein synthesis of cMYC, which, in turn, enhances the expression of key genes involved in translation. We analyzed a retrospective cohort of 97 mesothelioma patients' samples from our institution, revealing that linc00941 expression strongly correlates with reduced survival probability. This discovery clarifies linc00941's role in mesothelioma and proposes a unified mechanism of action for this lncRNA involving the selective translation of essential oncogenes, reconciling the discrepancies about its function.},
}
@article {pmid38724155,
year = {2024},
author = {Bluhm, M and Atmeh, B and Boehm, S and Rüschoff, JH and Bode, P and Dommann-Scherrer, C},
title = {Pleural Effusion Caused by an Unusual Mass in the Right Hemithorax.},
journal = {Chest},
volume = {165},
number = {5},
pages = {e151-e155},
doi = {10.1016/j.chest.2024.01.025},
pmid = {38724155},
issn = {1931-3543},
mesh = {Humans ; Female ; Aged, 80 and over ; *Tomography, X-Ray Computed ; Pleural Effusion/etiology/diagnosis ; Diagnosis, Differential ; Pleural Neoplasms/complications/diagnosis ; },
abstract = {An 80-year-old woman presented with complaints of weakness and dizziness. She had a medical history of subacute cerebral ischemia, vertigo, hypertension, and thalassemia minor. The patient was born and raised in Turkey and has lived in Switzerland for 50 years. Her sister died of a mesothelioma caused by asbestos exposure at the age of 60 years but had lived in Turkey until her death. The patient had neither a history of TB nor B symptoms. She has never smoked.},
}
@article {pmid38722058,
year = {2024},
author = {Stirpe, E and Bardaro, F and Köhl, J},
title = {Gluteal muscle metastases from malignant pleural mesothelioma: a case report.},
journal = {Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace},
volume = {},
number = {},
pages = {},
doi = {10.4081/monaldi.2024.2629},
pmid = {38722058},
issn = {2532-5264},
abstract = {Malignant pleural mesothelioma (MPM) is a rare malignancy arising from the mesothelial or subthelial layer of the pleura, and it has increased in recent decades, mainly associated with asbestos exposure. Sarcomatoid mesothelioma is the second-most common subtype of MPM. It is usually difficult to differentiate MPM from benign mesothelial pleural proliferations or other cancers. Because of its nonspecific symptoms, MPM is often diagnosed at a late stage with distal metastases. However, it is extremely rare to see a metastatic lesion within subcutaneous tissue and muscles, which is most likely caused by hematogenous spread. We present a case of sarcomatoid mesothelioma with a metastatic lesion of the right gluteal muscles.},
}
@article {pmid38711818,
year = {2024},
author = {Syed Ahmad, SD and Kirk, F and Wijesinghe, W and He, C and Stroebel, A},
title = {A peculiar presentation of tamponade: pericardial mesothelioma.},
journal = {Journal of surgical case reports},
volume = {2024},
number = {5},
pages = {rjae279},
pmid = {38711818},
issn = {2042-8812},
abstract = {Pericardial mesothelioma (PM) is rare with only 200 cases recorded, and a post-mortem prevalence of <0.0022%. It is the third most common cardiac/pericardial tumour, behind angiosarcoma and rhabdomyosarcoma. PM incidence increases with age, typically incidentally diagnosed between 50 and 70 years, with a 3:1 male predominance. Occasional PM can cause chest pain, dyspnoea, cough and even dysphagia. PMs are often misdiagnosed with only 25% of cases being antemortem diagnoses. Unlike pleural mesothelioma, the link between asbestos exposure and malignancy is less convincing, with only 20% of cases having known exposure. 6 There are three histological types: epithelioid, fibrous (spindle cell), and biphasic (mixed). The average life-expectancy post diagnosis is 3-10 months. Due to the heterogeneity of the presentation and rarity there is no standardized management algorithm, and the diagnostic imaging or laboratory investigations are scarcely described. We are presenting one of the cases diagnosed in our unit here in the Gold Coast.},
}
@article {pmid38702329,
year = {2024},
author = {Chin, WL and Zemek, RM and Tilsed, CM and Forrest, ARR and Fear, VS and Forbes, C and Boon, L and Bosco, A and Guo, BB and Millward, MJ and Nowak, AK and Lake, RA and Lesterhuis, WJ and Lassmann, T},
title = {Time-course RNAseq data of murine AB1 mesothelioma and Renca renal cancer following immune checkpoint therapy.},
journal = {Scientific data},
volume = {11},
number = {1},
pages = {448},
pmid = {38702329},
issn = {2052-4463},
support = {APP1154524//Department of Health | National Health and Medical Research Council (NHMRC)/ ; },
mesh = {Animals ; Mice ; *Carcinoma, Renal Cell/drug therapy/genetics ; *Immune Checkpoint Inhibitors/therapeutic use ; *Kidney Neoplasms/drug therapy/genetics ; *Mesothelioma/drug therapy/genetics ; RNA-Seq ; Sequence Analysis, RNA ; Single-Cell Analysis ; *Tumor Microenvironment ; },
abstract = {Time-critical transcriptional events in the immune microenvironment are important for response to immune checkpoint blockade (ICB), yet these events are difficult to characterise and remain incompletely understood. Here, we present whole tumor RNA sequencing data in the context of treatment with ICB in murine models of AB1 mesothelioma and Renca renal cell cancer. We sequenced 144 bulk RNAseq samples from these two cancer types across 4 time points prior and after treatment with ICB. We also performed single-cell sequencing on 12 samples of AB1 and Renca tumors an hour before ICB administration. Our samples were equally distributed between responders and non-responders to treatment. Additionally, we sequenced AB1-HA mesothelioma tumors treated with two sample dissociation protocols to assess the impact of these protocols on the quality transcriptional information in our samples. These datasets provide time-course information to transcriptionally characterize the ICB response and provide detailed information at the single-cell level of the early tumor microenvironment prior to ICB therapy.},
}
@article {pmid38699968,
year = {2024},
author = {Lombardo, C and Maugeri, G and D'Amico, AG and Broggi, G and Caltabiano, R and Filetti, V and Matera, S and D'Agata, V and Loreto, C},
title = {Pleural mesothelioma from fluoro-edenite exposure: PACAP and PAC1 receptor. A preliminary report.},
journal = {European journal of histochemistry : EJH},
volume = {68},
number = {2},
pages = {},
pmid = {38699968},
issn = {2038-8306},
mesh = {Humans ; *Pituitary Adenylate Cyclase-Activating Polypeptide/metabolism ; Male ; *Mesothelioma/metabolism/pathology/chemically induced ; Middle Aged ; *Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I/metabolism ; Female ; *Pleural Neoplasms/metabolism/pathology/chemically induced ; Aged ; Asbestos, Amphibole/toxicity ; Mesothelioma, Malignant/metabolism/pathology ; Lung Neoplasms/metabolism/pathology/chemically induced ; Immunohistochemistry ; Biomarkers, Tumor/metabolism ; },
abstract = {Pleural mesothelioma is a devastating malignancy primarily associated with asbestos exposure. However, emerging evidence suggests that exposure to fluoro-edenite fibers, a naturally occurring mineral fiber, can also lead to the development of pleural mesothelioma. In this study, based on the hypothesis that pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-preferring receptor (PAC1R) expressions could be dysregulated in pleural mesothelioma samples and that they could potentially act as diagnostic or prognostic biomarkers, we aimed to investigate the immunohistochemical expression of PACAP and PAC1R in pleural biopsies from patients with pleural mesothelioma exposed to fluoro-edenite fibers. A total of 12 patients were included in this study, and their biopsies were processed for immunohistochemical analysis to evaluate the expression of PACAP and its receptor. The study revealed a correlation between the overexpression of PACAP and PAC1R and shorter overall survival in patients with malignant mesothelioma. These findings suggest that PACAP and PAC1R expression levels could serve as potential prognostic biomarkers for malignant mesothelioma. Furthermore, the immunohistochemical analysis of PACAP and PAC1R may provide valuable information for clinicians to guide therapeutic decisions and identify patients with poorer prognosis.},
}
@article {pmid38694815,
year = {2024},
author = {Fisher, SA and Patrick, K and Hoang, T and Marcq, E and Behrouzfar, K and Young, S and Miller, TJ and Robinson, BWS and Bueno, R and Nowak, AK and Lesterhuis, WJ and Morahan, G and Lake, RA},
title = {The MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop.},
journal = {Frontiers in toxicology},
volume = {6},
number = {},
pages = {1373003},
pmid = {38694815},
issn = {2673-3080},
abstract = {Objectives: This study combines two innovative mouse models in a major gene discovery project to assess the influence of host genetics on asbestos related disease (ARD). Conventional genetics studies provided evidence that some susceptibility to mesothelioma is genetic. However, the identification of host modifier genes, the roles they may play, and whether they contribute to disease susceptibility remain unknown. Here we report a study designed to rapidly identify genes associated with mesothelioma susceptibility by combining the Collaborative Cross (CC) resource with the well-characterised MexTAg mesothelioma mouse model. Methods: The CC is a powerful mouse resource that harnesses over 90% of common genetic variation in the mouse species, allowing rapid identification of genes mediating complex traits. MexTAg mice rapidly, uniformly, and predictably develop mesothelioma, but only after asbestos exposure. To assess the influence of host genetics on ARD, we crossed 72 genetically distinct CC mouse strains with MexTAg mice and exposed the resulting CC-MexTAg (CCMT) progeny to asbestos and monitored them for traits including overall survival, the time to ARD onset (latency), the time between ARD onset and euthanasia (disease progression) and ascites volume. We identified phenotype-specific modifier genes associated with these traits and we validated the role of human orthologues in asbestos-induced carcinogenesis using human mesothelioma datasets. Results: We generated 72 genetically distinct CCMT strains and exposed their progeny (2,562 in total) to asbestos. Reflecting the genetic diversity of the CC, there was considerable variation in overall survival and disease latency. Surprisingly, however, there was no variation in disease progression, demonstrating that host genetic factors do have a significant influence during disease latency but have a limited role once disease is established. Quantitative trait loci (QTL) affecting ARD survival/latency were identified on chromosomes 6, 12 and X. Of the 97-protein coding candidate modifier genes that spanned these QTL, eight genes (CPED1, ORS1, NDUFA1, HS1BP3, IL13RA1, LSM8, TES and TSPAN12) were found to significantly affect outcome in both CCMT and human mesothelioma datasets. Conclusion: Host genetic factors affect susceptibility to development of asbestos associated disease. However, following mesothelioma establishment, genetic variation in molecular or immunological mechanisms did not affect disease progression. Identification of multiple candidate modifier genes and their human homologues with known associations in other advanced stage or metastatic cancers highlights the complexity of ARD and may provide a pathway to identify novel therapeutic targets.},
}
@article {pmid38692809,
year = {2024},
author = {Li, H and Husain, AN and Moffat, D and Klebe, S},
title = {Nonmesothelial Spindle Cell Tumors of Pleura and Pericardium.},
journal = {Surgical pathology clinics},
volume = {17},
number = {2},
pages = {257-270},
doi = {10.1016/j.path.2024.01.001},
pmid = {38692809},
issn = {1875-9157},
mesh = {Humans ; *Pericardium/pathology ; *Pleural Neoplasms/pathology/diagnosis ; Diagnosis, Differential ; Heart Neoplasms/pathology/diagnosis ; Mesothelioma/pathology/diagnosis ; Sarcoma/pathology/diagnosis ; Biomarkers, Tumor/analysis ; Pleura/pathology ; },
abstract = {Spindle cell lesions of the pleura and pericardium are rare. Distinction from sarcomatoid mesothelioma, which has a range of morphologic patterns, can be difficult, but accurate diagnosis matters. This article provides practical guidance for the diagnosis of pleural spindle cell neoplasms, focusing on primary lesions.},
}
@article {pmid38692064,
year = {2024},
author = {Nuvoli, B and Sacconi, A and Bottillo, G and Sciarra, F and Libener, R and Maconi, A and Carosi, M and Piperno, G and Mastropasqua, E and Papale, M and Camera, E and Galati, R},
title = {DHEA-S, Androstenedione, 17-β-estradiol signature as novel biomarkers for early prediction of risk of malignant pleural mesothelioma linked to asbestos-exposure: A preliminary investigation.},
journal = {Biomedicine &amp; pharmacotherapy = Biomedecine &amp; pharmacotherapie},
volume = {175},
number = {},
pages = {116662},
doi = {10.1016/j.biopha.2024.116662},
pmid = {38692064},
issn = {1950-6007},
mesh = {Humans ; *Estradiol/blood ; Male ; *Biomarkers, Tumor/blood ; *Androstenedione/blood ; *Asbestos/toxicity/adverse effects ; Female ; Middle Aged ; *Occupational Exposure/adverse effects ; Aged ; *Mesothelioma, Malignant/blood/diagnosis ; *Lung Neoplasms/blood/diagnosis ; Mesothelioma/blood/diagnosis/chemically induced ; Pleural Neoplasms/blood/diagnosis/chemically induced ; Dehydroepiandrosterone/blood ; Case-Control Studies ; Early Detection of Cancer/methods ; },
abstract = {17-β-estradiol, involved in mesothelioma pathogenesis, and its precursors were explored as potential biomarkers for the early diagnosis of mesothelioma. Using enzyme-linked immunosorbent assay(ELISA) for 17-β-estradiol and ultra-high performance liquid chromatography/tandem mass spectrometry(UHPLC-MS/MS) for 19 17-β-estradiol precursors, a comprehensive analysis of 20steroid hormones was conducted in the serum of mesothelioma patients(n=67), asbestos-exposed healthy subjects(n=39), and non-asbestos-exposed healthy subjects(n=35). Bioinformatics analysis explored three potential serum biomarkers: 17-β-estradiol, DHEA-S, and androstenedione. The results revealed significant differences in 17-β-estradiol levels between mesothelioma patients and both non-asbestos-exposed and asbestos-exposed healthy subjects. No significant variations in serum 17-β-estradiol levels were observed among mesothelioma patients at different stages, suggesting its potential as an early diagnostic marker. 17-β-estradiol levels were similar in mesothelioma patients with environmental and occupational asbestos exposure, while males with occupational asbestos exposure exhibited significantly higher levels of 17-β-estradiol compared to females. Significant reduction in androstenedione and an increase in DHEA-S were observed in asbestos-exposed individuals compared to non-asbestos-exposed individuals. The analysis of DHEA-S-androstenedione-17-β-estradiol signature score showed an increase in asbestos-exposed individuals and mesothelioma patients compared to non-asbestos-exposed individuals, and this score effectively distinguished between the groups. The Cancer Genome Atlas data was utilized to analyze the expression of 5-α-reductase1 and hydroxysteroid-17β-dehydrogenase2 genes. The findings indicated that mesothelioma patients with elevated gene values for 5-α-reductase1 and hydroxysteroid-17β-dehydrogenase2 have a worse or better prognosis on overall survival, respectively. In conclusion, this study suggests 17-β-estradiol, DHEA-S, and androstenedione as biomarkers for mesothelioma risk and early diagnosis of mesothelioma in asbestos-exposed individuals, aiding timely intervention and improved care.},
}
@article {pmid38671450,
year = {2024},
author = {Gogou, E and Hatzoglou, C and Siachpazidou, D and Zarogiannis, SG and Gourgoulianis, KI},
title = {Asbestos ban policies and mesothelioma mortality in Greece.},
journal = {BMC public health},
volume = {24},
number = {1},
pages = {1177},
pmid = {38671450},
issn = {1471-2458},
mesh = {Humans ; Greece/epidemiology ; Male ; Female ; *Asbestos ; *Mesothelioma/mortality ; Middle Aged ; Aged ; Adult ; Mesothelioma, Malignant/mortality ; Aged, 80 and over ; Environmental Exposure/adverse effects ; Lung Neoplasms/mortality ; },
abstract = {BACKGROUND: Malignant mesothelioma is a rare form of cancer that mostly affects the pleura and has a strong link to asbestos exposure. Greece banned the use of asbestos in 2005, however, the public was already aware of this substance in the 1980s. This research aims to present an overview of Greece's mesothelioma age-standardized mortality rates (ASMR) from 1983 to 2019 by age, gender, and geographic region and to determine whether the actions to ban asbestos impacted these rates.<br><br>METHODS: Data were retrieved by the Hellenic Statistical Authority (HSA) from death certificates that mentioned mesothelioma as the cause of death from 1983 to 2019 with details on the residence, gender, and age. Statistical analysis was performed using PRISM 6.0 software, a two-way ANOVA test, Trend analysis was conducted using Joinpoint Regression Program 5.0 software. The linear and non-linear model was used to calculate the age-standardized rates of annual percentage change (APC) and its 95% confidential interval (95% CI).<br><br>RESULTS: From 1983 to 2019, 850 total mesothelioma deaths were recorded, the majority of whom were males (634). A rate of 74.6% accounts for males and 25.4% for females, and the ratio of Males: Females was 3:1. Males' ASMR and the whole population's ASMR reached their highest levels in 2011 (0.93/100000person-years and 0.53/100000person-years, respectively). To look for potential changes between the first two decades of the 21st century, we compared the mean ASMR of each geographic region in Greece between two different 10-year subperiods (2000-2009 and 2010-2019). Except for Epirus, all regions of Greece had elevated regional ASMRs, particularly in those with the highest asbestos deposits. Notably, the ASMR in Epirus decreased from 0.54/100000person-years (2000-2009) to 0.31/100000person-years (2010-2019). After 2011, the ASMR for men and the general population stabilized. This stability is important since mesothelioma in men is associated with occupational asbestos exposure. The intriguing discovery of a lower ASMR in Epirus emphasizes the need to raise awareness of the condition and implement effective public health measures.<br><br>CONCLUSIONS: In Greece, the annual ASMR for males and the whole population reached its highest level in 2011, which is positive and encouraging and may be a sign that the rate will stabilize during the following years. Moreover, this study showed that the actions made in the 1980s regarding public awareness and surveillance directly impacted the decrease in Epirus rates. Future research, continual awareness, information, and recording are needed to monitor the mesothelioma epidemic. The possible benefit of a mesothelioma registry and the epidemiological surveillance of asbestos-related diseases, particularly mesothelioma mortality, need to be addressed.<br><br>TRIAL REGISTRATION: Not applicable.},
}
@article {pmid38662022,
year = {2024},
author = {Feder, IS and Fruth, E and Tannapfel, A},
title = {[Asbestos: detection and characterization in tissue].},
journal = {Pathologie (Heidelberg, Germany)},
volume = {45},
number = {5},
pages = {333-338},
pmid = {38662022},
issn = {2731-7196},
mesh = {Humans ; *Asbestos/adverse effects/analysis ; *Asbestosis/pathology/diagnosis ; *Lung/pathology/drug effects ; Mesothelioma/diagnosis/chemically induced/pathology/etiology ; Occupational Exposure/adverse effects/analysis ; Lung Neoplasms/diagnosis/pathology ; Microscopy/methods ; },
abstract = {BACKGROUND: When asbestos fibers are inhaled, asbestos bodies can form in the lungs with the involvement of macrophages. It can take decades from the last exposure to the onset of an asbestos-related disease.<br><br>OBJECTIVES: The aim of this review is to present methods to detect asbestos bodies in lung tissue, the development of diagnostic criteria and to discuss pros and cons of different methods.<br><br>MATERIALS AND METHODS: Observations and evaluations from the German Mesothelioma Register, along with relevant literature review and expert recommendations in guidelines are presented.<br><br>RESULTS: Assessing asbestos-related diseases requires recognition of the person's occupational history, the asbestos fiber burden in the lungs, and determining fiber types. Various methods have been developed and validated, including light microscopy techniques such as bright-field microscopy, phase-contrast microscopy, polarization microscopy, and differential interference microscopy, as well as electron microscopy techniques like field-emission-scanning electron microscopy (e.g., FE-SEM) and transmission electron microscopy (TEM).<br><br>CONCLUSION: The use of asbestos has been heavily restricted worldwide, even completely banned in Europe. Thus, patients' exposure to asbestos is decreasing. However, asbestos exposure during renovations, demolitions, or through unconscious handling of asbestos-containing materials remains a&#xa0;concern.},
}
@article {pmid38642958,
year = {2024},
author = {Gómez Herrero, H and Álvarez Galván, B},
title = {Analysis of invasive diagnostic techniques for pathological confirmation of pleural mesothelioma.},
journal = {Radiologia},
volume = {66 Suppl 1},
number = {},
pages = {S3-S9},
doi = {10.1016/j.rxeng.2023.03.005},
pmid = {38642958},
issn = {2173-5107},
mesh = {Male ; Humans ; Female ; Aged ; *Mesothelioma/diagnostic imaging/etiology ; *Pleural Neoplasms/diagnostic imaging/etiology ; *Asbestos/adverse effects ; *Pleural Effusion/chemically induced/complications/pathology ; Diagnostic Imaging ; },
abstract = {BACKGROUND AND OBJECTIVES: Mesothelioma is an infrequent neoplasm with a poor prognosis that is related to exposure to asbestos and whose peak incidence in Europe is estimated from 2020. Its diagnosis is complex; imaging techniques and the performance of invasive pleural techniques being essential for pathological confirmation. The different diagnostic yields of these invasive techniques are collected in the medical literature. The present work consisted of reviewing how the definitive diagnosis of mesothelioma cases in our centre was reached to check if there was concordance with the data in the bibliography.<br><br>MATERIALS AND METHODS: Retrospective review of patients with a diagnosis of pleural mesothelioma in the period 2019-2021, analysing demographic data and exposure to asbestos, the semiology of the radiological findings and the invasive techniques performed to reach the diagnosis.<br><br>RESULTS: Twenty-six mesothelioma cases were reviewed. 22 men and 4 women. Median age 74 years. 9 patients had a history of asbestos exposure. Moderate-severe pleural effusion was the most frequent radiological finding (23/26). The sensitivity of the invasive techniques was as follows: Cytology 13%, biopsy without image guidance 11%, image-guided biopsy 93%, surgical biopsy 67%.<br><br>CONCLUSIONS: In our review, pleural biopsy performed with image guidance was the test that had the highest diagnostic yield, so it should be considered as the initial invasive test for the study of mesothelioma.},
}
@article {pmid38640636,
year = {2024},
author = {Ejegi-Memeh, S and Sherborne, V and Mayland, C and Tod, A and Taylor, BH},
title = {Mental health and wellbeing in mesothelioma: A qualitative study exploring what helps the wellbeing of those living with this illness and their informal carers.},
journal = {European journal of oncology nursing : the official journal of European Oncology Nursing Society},
volume = {70},
number = {},
pages = {102572},
doi = {10.1016/j.ejon.2024.102572},
pmid = {38640636},
issn = {1532-2122},
mesh = {Humans ; Male ; Female ; Middle Aged ; *Qualitative Research ; *Caregivers/psychology ; Aged ; *Mesothelioma/psychology ; *Mental Health ; United Kingdom ; Quality of Life ; Adult ; Social Support ; Adaptation, Psychological ; Aged, 80 and over ; Interviews as Topic ; },
abstract = {PURPOSE: Mesothelioma is an incurable, asbestos related cancer with a poor prognosis. Little is known about how patients and carers living with the condition manage their mental health and wellbeing needs. This paper reports findings on interventions being used by patients and informal carers living with mesothelioma and those which they find most helpful.<br><br>METHODS: In-depth interviews with patients (n&#xa0;=&#xa0;10) and (informal) carers (n&#xa0;=&#xa0;11) living with mesothelioma in the UK. We analysed our data inductively using a reflexive thematic analysis approach.<br><br>RESULTS: Participants described the importance of both smaller and larger actions and strategies which helped with their mental health. This included spending more time with family and friends and going on holidays. Professionals who participants said supported their mental health journey included not only specialist nurses and mental health professionals but also legal and Asbestos Support Group professionals. The latter demonstrates the unique needs and support required for this population. Exposure to asbestos as the cause of mesothelioma, has led to a social justice aspect of the experience of living with this cancer. Participants reported the importance of collective action to their mental health and wellbeing. The data indicate that patients and carers may have distinct mental health and wellbeing requirements and need to manage these in different ways at different times.<br><br>CONCLUSIONS: Findings have implications for nurses and other key professionals working in healthcare, community and legal settings supporting this client group, and for those living with mesothelioma who want to understand ways to enhance their own wellbeing.},
}
@article {pmid38634609,
year = {2024},
author = {Liu, RA and Wang, BY and Chen, X and Pu, YQ and Zi, JJ and Mei, W and Zhang, YP and Qiu, L and Xiong, W},
title = {Association Study of Pleural Mesothelioma and Oncogenic Simian Virus 40 in the Crocidolite-Contaminated Area of Dayao County, Yunnan Province, Southwest China.},
journal = {Genetic testing and molecular biomarkers},
volume = {28},
number = {5},
pages = {189-198},
doi = {10.1089/gtmb.2023.0532},
pmid = {38634609},
issn = {1945-0257},
mesh = {Humans ; *Simian virus 40/genetics ; China/epidemiology ; Male ; Female ; Middle Aged ; Aged ; *Pleural Neoplasms/epidemiology/virology/genetics ; *Asbestos, Crocidolite ; Mesothelioma/virology/epidemiology/genetics ; Polyomavirus Infections/epidemiology ; Tumor Virus Infections/epidemiology ; Cell Line, Tumor ; Mesothelioma, Malignant/genetics ; Lung Neoplasms/virology/genetics/epidemiology ; Adult ; },
abstract = {Background: In Dayao County, Chuxiong Yi Autonomous Prefecture, Yunnan Province, Southwest China, 5% of the surface is scattered with blue asbestos, which has a high incidence of pleural mesothelioma (PMe). Simian virus 40 (SV40) is a small circular double-stranded DNA polyomavirus that can cause malignant transformation of normal cells of various human and animal tissue types and promote tumor growth. In this study, we investigate whether oncogenic SV40 is associated with the occurrence of PMe in the crocidolite-contaminated area of Dayao County, Yunnan Province, Southwest China. Methods: Tumor tissues from 51 patients with PMe (40 of whom had a history of asbestos exposure) and pleural tissues from 12 non-PMe patients (including diseases such as pulmonary maculopathy and pulmonary tuberculosis) were collected. Three pairs of low-contamination risk primers (SVINT, SVfor2, and SVTA1) were used to detect the gene fragment of SV40 large T antigen (T-Ag) by polymerase chain reaction (PCR). The presence of SV40 T-Ag in PMe tumor tissues and PMe cell lines was detected by Western blotting and immunohistochemical staining with SV40-related antibodies (PAb 101 and PAb 416). Results: PCR, Western blotting, and immunohistochemical staining results showed that the Met5A cell line was positive for SV40 and contained the SV40 T-Ag gene and protein. In contrast, the various PMe cell lines NCI-H28, NCI-H2052, and NCI-H2452 were negative for SV40. PCR was negative for all three sets of low-contamination risk primers in 12 non-PMe tissues and 51 PMe tissues. SV40 T-Ag was not detected in 12 non-PMe tissues or 51 PMe tissues by immunohistochemical staining. Conclusion: Our data suggest that the occurrence of PMe in the crocidolite-contaminated area of Yunnan Province may not be related to SV40 infection and that crocidolite exposure may be the main cause of PMe. The Clinical Trial Registration number: 2020-YXLL20.},
}
@article {pmid38630790,
year = {2024},
author = {Yang, SR and Jayakumaran, G and Benhamida, J and Febres-Aldana, CA and Fanaroff, R and Chang, J and Gedvilaite, E and Villafania, LB and Sauter, JL and Offin, M and Zauderer, MG and Ladanyi, M},
title = {Diffuse Pleural Mesotheliomas with Genomic Near-Haploidization: A Newly Recognized Subset with Distinct Clinical, Histologic, and Molecular Features.},
journal = {Clinical cancer research : an official journal of the American Association for Cancer Research},
volume = {30},
number = {13},
pages = {2780-2789},
pmid = {38630790},
issn = {1557-3265},
support = {P30 CA008748/CA/NCI NIH HHS/United States ; P30-CA008748//National Cancer Institute (NCI)/ ; },
mesh = {Humans ; Male ; Female ; Middle Aged ; Aged ; *Pleural Neoplasms/genetics/pathology/mortality ; Mutation ; Loss of Heterozygosity ; Mesothelioma/genetics/pathology ; Adult ; DNA Copy Number Variations ; Genomics/methods ; Biomarkers, Tumor/genetics ; Prognosis ; Aged, 80 and over ; Mesothelioma, Malignant/genetics/pathology ; Lung Neoplasms/genetics/pathology/mortality ; },
abstract = {PURPOSE: Diffuse pleural mesotheliomas (DPM) with genomic near-haploidization (GNH) represent a novel subtype first recognized by The Cancer Genome Atlas project; however, its clinicopathologic and molecular features remain poorly defined.<br><br>EXPERIMENTAL DESIGN: We analyzed clinical genomic profiling data from 290 patients with DPM using the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) assay. Allele-specific copy number analysis was performed using the Fraction and Allele-Specific Copy Number Estimates from Tumor Sequencing (FACETS) algorithm.<br><br>RESULTS: A total of 210 patients were evaluable for loss of heterozygosity (LOH) analysis using FACETS from MSK-IMPACT tumor:normal sequencing data. In this cohort, GNH, defined as LOH across >80% of the genome, was detected in 10 cases (4.8%). Compared with non-GNH tumors, GNH DPMs were associated with younger age and less frequent self-reported history of occupational asbestos exposure. Histologically, GNH DPMs were enriched in biphasic subtype (80% vs. 14.5%) and showed abundant tumor-infiltrating lymphocytes (TILs). Genomic analysis revealed a higher frequency of TP53 alterations, whereas SETDB1 mutations were present in nearly all and only in this subset. The clinicopathologic and molecular findings were further validated in a separate cohort. Despite the younger age, patients with GNH DPMs had a shorter overall survival (10.9 vs. 25.4 months, P = 0.004); the poor prognostic impact of GNH remained significant after controlling for biphasic histology. Of three patients with GNH DPMs who received immune checkpoint blockade, two achieved a clinician-assessed partial response.<br><br>CONCLUSIONS: GNH defines an aggressive subtype of mainly biphasic DPMs in younger patients with recurrent alterations in SETDB1 and TP53. The enrichment in biphasic histology and TILs, together with our preliminary immune checkpoint blockade response data and anecdotal clinical trial data, suggests that further evaluation of immunotherapy may be warranted in this subset.},
}
@article {pmid38629360,
year = {2024},
author = {Mirra, L and Beretta, GL and Lisini, D and Marcianti, A and Spampinato, E and Corno, C and Costantino, M and Corsico, A and Stella, GM and Perego, P},
title = {Therapeutic Strategies to Improve the Treatment of Pleural Mesothelioma.},
journal = {Current medicinal chemistry},
volume = {},
number = {},
pages = {},
doi = {10.2174/0109298673268206240405084558},
pmid = {38629360},
issn = {1875-533X},
abstract = {Pleural mesothelioma is a rare neoplastic disease with aggressive features. Patient survival is poor due to the lack of early symptoms and the absence of effective therapeutic strategies. The development of pleural mesothelioma is mainly associated with asbestos exposure and related chronic inflammation. From a molecular-based perspective, this disease is a heterogeneous tumor lacking actionable alterations. The median overall survival of patients affected by this tumor does not exceed 16 months from diagnosis. Molecular and biochemical approaches have shown that this disease is characterized by resistance to drug-induced apoptosis associated with the activation of cell survival pathways and expression of anti-apoptotic proteins. Thus, there is an urgent need to develop efficient and safe therapeutic strategies. Here, we review the pharmacological options available for the treatment of this disease with specific reference to the antitumor agents used in systemic therapies. In addition, novel pharmacological approaches, such as drug delivery tools, to improve pleural mesothelioma treatment are discussed.},
}
@article {pmid38619810,
year = {2024},
author = {Gibson, AEJ and Ahmed, W and Longworth, L and Bennett, B and Daumont, M and Darlison, L},
title = {Development of Patient and Caregiver Conceptual Models Investigating the Health-Related Quality of Life Impacts of Malignant Pleural Mesothelioma.},
journal = {The patient},
volume = {17},
number = {5},
pages = {551-563},
pmid = {38619810},
issn = {1178-1661},
mesh = {Humans ; *Quality of Life ; Male ; Female ; *Caregivers/psychology ; Middle Aged ; *Mesothelioma, Malignant/psychology ; Aged ; United Kingdom ; Qualitative Research ; Australia ; Pleural Neoplasms/psychology ; Interviews as Topic ; Adult ; Aged, 80 and over ; Lung Neoplasms/psychology ; },
abstract = {BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare and usually fatal malignancy frequently linked to occupational asbestos exposures and associated with poor prognosis and considerable humanistic burden. The study aimed to develop conceptual models of the health-related quality of life (HRQoL) impact on patients with and receiving treatment for MPM, and the burden on their caregivers.<br><br>METHODS: This multi-country study (Australia and United Kingdom) adopted a qualitative methodology to conduct semi-structured, independent interviews with people with MPM (n = 26), current caregivers (n = 20), and caregivers of people who had recently died because of MPM (n = 4). Participants were recruited using a purposive sampling approach and interviews conducted via telephone between January 2021 and January 2022. Transcripts were analysed using thematic analysis and used to construct conceptual models.<br><br>RESULTS: Patient analysis yielded four overarching themes: (1) debilitating burden of breathlessness and fatigue; (2) physical mesothelioma symptoms experienced by patients; (3) distress of MPM on the self and family; and (4) treatment is worth 'having a go' despite the potential impact on symptoms. Caregiver analysis yielded five core themes: (1) daily life limited by caregiving duties; (2) emotional well-being and the need for support; (3) the relational role shift to caregiver; (4) time spent providing care negatively impacts work and productivity; and (5) positive aspects and outcomes of caregiving.<br><br>CONCLUSIONS: This study highlights the substantial daily and emotional HRQoL impact that MPM symptoms have on patients and caregivers. Both groups reduced work, productivity, and social and leisure activities. There was evidence of positive HRQoL impacts as a result of immunotherapy and radiotherapy, but less for chemotherapy. Caregiver impacts were intensified during the end-of-life period and persisted following patient death. Evident is a need for increased psychological support, information, and advice for caregivers, increased during the end-of-life period.},
}
@article {pmid38619498,
year = {2024},
author = {Miller, E and Beckett, EM and Cheatham, D and Comerford, CE and Lewis, RC and Krevanko, C and Mandava, N and Pierce, JS},
title = {A review of the mesotheliogenic potency of cleavage fragments found in talc.},
journal = {Toxicology and industrial health},
volume = {40},
number = {7},
pages = {398-424},
doi = {10.1177/07482337241246924},
pmid = {38619498},
issn = {1477-0393},
mesh = {*Talc/chemistry ; Humans ; Animals ; *Asbestos, Amphibole ; Mesothelioma/chemically induced ; Occupational Exposure/adverse effects ; },
abstract = {It has long been recognized that amphibole minerals, such as cleavage fragments of tremolite and anthophyllite, may exist in some talc deposits. We reviewed the current state of the science regarding the factors influencing mesotheliogenic potency of cleavage fragments, with emphasis on those that may co-occur in talc deposits, including dimensional and structural characteristics, animal toxicology, and the most well-studied cohort exposed to talc-associated cleavage fragments. Based on our review, multiple lines of scientific evidence demonstrate that inhaled cleavage fragments associated with talc do not pose a mesothelioma hazard.},
}
@article {pmid38592450,
year = {2024},
author = {Kadariya, Y and Sementino, E and Ruan, M and Cheung, M and Hadikhani, P and Osmanbeyoglu, HU and Klein-Szanto, AJ and Cai, K and Testa, JR},
title = {Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment.},
journal = {Cancer research communications},
volume = {4},
number = {4},
pages = {1004-1015},
pmid = {38592450},
issn = {2767-9764},
support = {R00 CA207871/CA/NCI NIH HHS/United States ; },
mesh = {Humans ; Animals ; Mice ; *Mesothelioma, Malignant ; Asbestos, Serpentine ; Asbestos, Amphibole ; Asbestos, Crocidolite/toxicity ; Tumor Microenvironment/genetics ; *Mesothelioma/chemically induced ; *Neoplasms, Mesothelial ; Adenosine ; Immunosuppressive Agents ; Germ Cells ; },
abstract = {UNLABELLED: Asbestos and BAP1 germline mutations are risk factors for malignant mesothelioma (MM). While it is well accepted that amphibole asbestos is carcinogenic, the role of serpentine (chrysotile) asbestos in MM has been debated. To address this controversy, we assessed whether minimal exposure to chrysotile could significantly increase the incidence and rate of MM onset in germline Bap1-mutant mice. With either crocidolite or chrysotile, and at each dose tested, MMs occurred at a significantly higher rate and earlier onset time in Bap1-mutant mice than in wild-type littermates. To explore the role of gene-environment interactions in MMs from Bap1-mutant mice, we investigated proinflammatory and protumorigenic factors and the tumor immune microenvironment (TIME). IHC and immunofluorescence staining showed an increased number of macrophages in granulomatous lesions and MMs. The relative number of CD163-positive (CD163+) M2 macrophages in chrysotile-induced MMs was consistently greater than in crocidolite-induced MMs, suggesting that chrysotile induces a more profound immunosuppressive response that creates favorable conditions for evading immune surveillance. MMs from Bap1-mutant mice showed upregulation of CD39/CD73-adenosine and C-C motif chemokine ligand 2 (Ccl2)/C-C motif chemokine receptor 2 (Ccr2) pathways, which together with upregulation of IL6 and IL10, promoted an immunosuppressive TIME, partly by attracting M2 macrophages. Interrogation of published human MM RNA sequencing (RNA-seq) data implicated these same immunosuppressive pathways and connections with CD163+ M2 macrophages. These findings indicate that increased M2 macrophages, along with upregulated CD39/CD73-adenosine and Ccl2/Ccr2 pathways, contribute to an immunosuppressive TIME in chrysotile-induced MMs of Bap1-mutant mice, suggesting that immunotherapeutic strategies targeting protumorigenic immune pathways could be beneficial in human BAP1 mutation carriers who develop MM.<br><br>SIGNIFICANCE: We show that germline Bap1-mutant mice have enhanced susceptibility to MM upon minimal exposure to chrysotile asbestos, not only amphibole fibers. Chrysotile induced a more profound immune tumor response than crocidolite in Bap1-mutant mice by upregulating CD39/CD73-adenosine and Ccl2/Ccr2 pathways and recruiting more M2 macrophages, which together contributed to an immunosuppressive tumor microenvironment. Interrogation of human MM RNA-seq data revealed interconnected immunosuppressive pathways consistent with our mouse findings.},
}
@article {pmid38583132,
year = {2024},
author = {Stevens, ME and Paustenbach, DJ and Lockhart, NJ and Busboom, DE and Deckard, BM and Brew, DW},
title = {The presence of erionite in North American geologies and the estimated mesothelioma potency by region.},
journal = {Inhalation toxicology},
volume = {36},
number = {3},
pages = {158-173},
doi = {10.1080/08958378.2024.2322496},
pmid = {38583132},
issn = {1091-7691},
mesh = {Humans ; Asbestos, Crocidolite/toxicity ; Asbestos, Serpentine/toxicity ; Asbestos, Amosite/toxicity ; *Mesothelioma/chemically induced/epidemiology ; *Mesothelioma, Malignant/complications ; *Asbestos/toxicity ; *Zeolites ; Montana ; *Lung Neoplasms/epidemiology ; },
abstract = {OBJECTIVE: Erionite is a naturally occurring fibrous mineral found in soils in some geographical regions. Known for its potency for causing mesothelioma in the Cappadocia region of Turkey, the erionite fiber has attracted interest in the United States due to its presence in a band of rock that extends from Mexico to Montana. There are few toxicology studies of erionite, but all show it to have unusually high chronic toxicity. Despite its high potency compared to asbestos fibers, erionite has no occupational or environmental exposure limits. This paper takes what has been learned about the chemical and physical characteristics of the various forms of asbestos (chrysotile, amosite, anthophyllite, and crocidolite) and predicts the potency of North American erionite fibers.<br><br>MATERIALS AND METHODS: Based on the fiber potency model in Korchevskiy et al. (2019) and the available published information on erionite, the estimated mesothelioma potency factors (the proportion of mesothelioma mortality per unit cumulative exposure (f/cc-year)) for erionites in the western United States were determined.<br><br>RESULTS AND DISCUSSION: The model predicted potency factors ranged from 0.19 to 11.25 (average &#x223c;3.5), depending on the region. For reference, crocidolite (the most potent commercial form of asbestos) is assigned a potency factor &#x223c;0.5.<br><br>CONCLUSION: The model predicted mesothelioma potency of Turkish erionite (4.53) falls in this same range of potencies as erionite found in North America. Although it can vary by region, a reasonable ratio of average mesothelioma potency based on this model is 3,000:500:100:1 comparing North American erionite, crocidolite, amosite, and chrysotile (from most potent to least potent).},
}
@article {pmid38552427,
year = {2024},
author = {Lanfranco, A and Rakhshan, S and Alberti, D and Renzi, P and Zarechian, A and Protti, N and Altieri, S and Crich, SG and Deagostino, A},
title = {Combining BNCT with carbonic anhydrase inhibition for mesothelioma treatment: Synthesis, in vitro, in vivo studies of ureidosulfamido carboranes.},
journal = {European journal of medicinal chemistry},
volume = {270},
number = {},
pages = {116334},
doi = {10.1016/j.ejmech.2024.116334},
pmid = {38552427},
issn = {1768-3254},
mesh = {Mice ; Animals ; *Carbonic Anhydrases ; *Boron Neutron Capture Therapy ; *Mesothelioma/drug therapy ; *Glioma/drug therapy ; *Melanoma/drug therapy ; Boron Compounds/therapeutic use ; },
abstract = {Mesothelioma is a malignant neoplasm of mesothelial cells caused by exposure to asbestos. The average survival time after diagnosis is usually nine/twelve months. A multi-therapeutic approach is therefore required to treat and prevent recurrence. Boronated derivatives containing a carborane cage, a sulfamido group and an ureido functionality (CA-USF) have been designed, synthesised and tested, in order to couple Boron Neutron Capture Therapy (BNCT) and the inhibition of Carbonic Anhydrases (CAs), which are overexpressed in many tumours. In vitro studies showed greater inhibition than the reference drug acetazolamide (AZ). To increase solubility in aqueous media, CA-USFs were used as inclusion complexes of hydroxypropyl β-cyclodextrin (HP-β-CD) in all the inhibition and cell experiments. BNCT experiments carried out on AB22 (murine mesothelioma) cell lines showed a marked inhibition of cell proliferation by CA-USFs, and in one case a complete inhibition of proliferation twenty days after neutron irradiation. Finally, in vivo neutron irradiation experiments on a mouse model of mesothelioma demonstrated the efficiency of combining CA IX inhibition and BNCT treatment. Indeed, a greater reduction in tumour mass was observed in treated mice compared to untreated mice, with a significant higher effect when combined with BNCT. For in vivo experiments CA-USFs were administered as inclusion complexes of higher molecular weight β-CD polymers thus increasing the selective extravasation into tumour tissue and reducing clearance. In this way, boron uptake was maximised and CA-USFs demonstrated to be in vivo well tolerated at a therapeutic dose. The therapeutic strategy herein described could be expanded to other cancers with increased CA IX activity, such as melanoma, glioma, and breast cancer.},
}
@article {pmid38538248,
year = {2024},
author = {Mei, W and Zhang, YP and Yang, SJ},
title = {[Research progress on pathogenesis of malignant mesothelioma].},
journal = {Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases},
volume = {42},
number = {3},
pages = {232-240},
doi = {10.3760/cma.j.cn121094-20221226-00604},
pmid = {38538248},
issn = {1001-9391},
support = {82160516//National Natural Science Foundation of China/ ; 2022J0716//Science Research Foundation of Education Department of Yunnan Province/ ; 202301BA070001-26, 202301BA070001-027//The Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities/ ; },
mesh = {Humans ; *Mesothelioma, Malignant/complications ; *Lung Neoplasms/genetics/pathology ; *Pleural Neoplasms/genetics ; *Mesothelioma/genetics/diagnosis ; *Asbestos ; },
abstract = {The occurrence of malignant mesothelioma is related to exposure of asbestos. And many researchers have conducted in-depth analysis of the molecular changes of mesothelioma, showed that its molecular characteristics were chromosome changes, including chromosome rearrangement, gene mutation and gene deletion. Recent studies have strengthened our understanding of molecular characterization of mesothelioma, such as targeted mutations of tumor suppressor genes, differential gene expression, changes of miRNA and signal pathways. It is of great significance for the early diagnosis, clinical treatment and prognosis of malignant mesothelioma to explore the pathogenesis and development of malignant mesothelioma. This article reviews the research progress on the pathogenesis and carcinogenesis-related molecules of malignant mesothelioma.},
}
@article {pmid38538239,
year = {2024},
author = {Wang, ZZ and Zhang, JJ and Song, PP and Zhang, H and Luo, LM and Luan, T},
title = {[Survival analysis of 37 cases of malignant mesothelioma].},
journal = {Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases},
volume = {42},
number = {3},
pages = {191-195},
doi = {10.3760/cma.j.cn121094-20230109-00012},
pmid = {38538239},
issn = {1001-9391},
mesh = {Humans ; Aged ; Middle Aged ; *Mesothelioma, Malignant ; *Mesothelioma/drug therapy ; Retrospective Studies ; *Pleural Neoplasms ; Prognosis ; Survival Analysis ; *Lung Neoplasms ; Survival Rate ; },
abstract = {Objective: To explore the relationship between clinicopathological features, treatment and prognosis of patients with malignant mesothelioma, and provide theoretical basis for the prevention and treatment of malignant mesothelioma. Methods: In November 2022, the clinical data of 37 patients with malignant mesothelioma diagnosed in Qingdao Central Hospital from July 2014 to November 2022 were retrospectively analyzed, and the prognostic factors were analyzed by Kaplan-Meier and log-rank tests. Results: The median age of the 37 patients was 66 years old, all patients were confirmed by pathology. The median survival time of all patients was 30.00 months. The 1-year, 2-year, 3-year and 5-year cumulative survival rates were 70.27% (26/37), 48.65% (18/37), 16.22% (6/37) and 13.51% (5/37), respectively. Compared with different treatments, the median survival time of palliative care patients was 5.00 months, which was significantly lower than that of operation group (30.33 months), chemotherapy group (30.00 months), surgery combined with chemotherapy group (30.00 months) and chemotherapy combined with bevacizumab targeted therapy group (47.42 months) (P<0.05). Gender, age (≥60 years old or <60 years old), smoking history, occupational exposure history, disease site, and surgical history were not factors affecting the survival of malignant mesothelioma patients (P>0.05) . Conclusion: The clinical symptoms of malignant mesothelioma are not specific, but early initiation of treatment can still prolong survival, and chemotherapy combined with anti-vascular targeted therapy shows better therapeutic effect.},
}
@article {pmid38532179,
year = {2024},
author = {Mirabelli, D and Somigliana, AB and Azzolina, D and Consonni, D and Barbieri, PG},
title = {Lung fibre burden and risk of malignant mesothelioma in shipyard workers: a necropsy-based case-control study.},
journal = {Annals of work exposures and health},
volume = {68},
number = {5},
pages = {476-485},
doi = {10.1093/annweh/wxae018},
pmid = {38532179},
issn = {2398-7316},
mesh = {Humans ; Male ; Case-Control Studies ; *Occupational Exposure/adverse effects ; *Mesothelioma/pathology/etiology/epidemiology ; Italy/epidemiology ; Middle Aged ; *Lung Neoplasms/pathology/etiology/epidemiology ; *Ships ; Aged ; *Mesothelioma, Malignant ; Mineral Fibers/analysis/adverse effects ; Occupational Diseases/epidemiology/etiology ; Lung/pathology ; Pleural Neoplasms/etiology/pathology/epidemiology ; Adult ; Odds Ratio ; Autopsy ; Asbestos/analysis/adverse effects ; Asbestos, Amphibole/analysis/adverse effects ; Asbestos, Serpentine/analysis/adverse effects ; Risk Factors ; },
abstract = {OBJECTIVES: In Italy, the highest pleural cancer mortality and incidence have been observed among Italian regions where the 2 largest Italian shipyards were (and are) located. The objective of this study was to assess the exposure-response relationship for mesothelioma among male workers employed in the Monfalcone, Italy, shipyard.<br><br>METHODS: We conducted a necropsy-based case-control study. Cases (N = 102) were mesothelioma decedents and controls were those with lung cancer (N = 84). Complete job histories were available; the lung fibre content was measured using a scanning electron microscope with X-ray fluorescence, after sample preparation according to the European Respiratory Society guidelines. Odds ratios and 95% confidence intervals of mesothelioma by fibre type and lung fibre burden, as a categorical or continuous variable, were assessed by unconditional logistic regression, adjusted for age and time since exposure cessation. Analyses for the amphibole and chrysotile lung fibre burden were mutually adjusted. We calculated a cumulative exposure index by applying a job-exposure matrix to the job histories of study cases and assessed its correlation with the lung fibre burden.<br><br>RESULTS: We found an odds ratio of 22.0 (confidence intervals 5.66-85.7) for the highest lung fibre burden category (mean 43.8 million total asbestos fibres per gram of dry tissue) compared with the reference (mean 0.48). Using log10-transformed lung fibre burden, we found that the odds ratio was 3.71 (confidence intervals 2.03-6.79) for a 10-fold lung fibre burden increase. Results for the amphibole lung fibre burden were similar. Odds ratios increased over chrysotile lung fibre burden categories (P-trend = 0.025), and the odds ratio for a 10-fold increase was 4.73 (confidence intervals 0.32-70.4).<br><br>CONCLUSIONS: The cumulative exposure index was correlated with total and amphibole lung fibre burden, but not with chrysotile lung fibre burden. Mesothelioma risk was proportional to total, amphibole, and chrysotile lung fibre burden in shipyard workers.},
}
@article {pmid38522452,
year = {2024},
author = {Burki, T},
title = {EPA ruling to ban chrysotile asbestos.},
journal = {The Lancet. Oncology},
volume = {25},
number = {5},
pages = {537},
doi = {10.1016/S1470-2045(24)00155-4},
pmid = {38522452},
issn = {1474-5488},
mesh = {*Asbestos, Serpentine/adverse effects ; Humans ; *United States Environmental Protection Agency/legislation &amp; jurisprudence ; United States ; Mesothelioma/chemically induced ; Occupational Exposure/legislation &amp; jurisprudence/adverse effects/prevention &amp; control ; Lung Neoplasms ; },
}
@article {pmid38522172,
year = {2024},
author = {Sherborne, V and Wood, E and Mayland, CR and Gardiner, C and Lusted, C and Bibby, A and Tod, A and Taylor, B and Ejegi-Memeh, S},
title = {The mental health and well-being implications of a mesothelioma diagnosis: A mixed methods study.},
journal = {European journal of oncology nursing : the official journal of European Oncology Nursing Society},
volume = {70},
number = {},
pages = {102545},
doi = {10.1016/j.ejon.2024.102545},
pmid = {38522172},
issn = {1532-2122},
mesh = {Humans ; Male ; Female ; *Mesothelioma/diagnosis/psychology ; Cross-Sectional Studies ; Middle Aged ; Aged ; *Quality of Life ; *Caregivers/psychology ; Adult ; Mental Health ; Depression/epidemiology/diagnosis ; Anxiety/epidemiology/diagnosis ; Aged, 80 and over ; Stress Disorders, Post-Traumatic/diagnosis/epidemiology ; Surveys and Questionnaires ; Mesothelioma, Malignant/diagnosis ; },
abstract = {PURPOSE: Mesothelioma is an incurable, asbestos-related cancer with a poor prognosis. There is scant evidence about the mental health and well-being impacts on patients and carers living with the illness. This study aimed to investigate mesothelioma's impact on mental health and well-being and the scale of mental health conditions in patients and informal carers.<br><br>METHODS: A mixed-methods design was used: a cross-sectional survey of mesothelioma patients and informal carers plus semi-structured interviews with patients and carers. The survey used validated scales collecting data on mental health aspects of mesothelioma: the EQ5D to assess health-related quality-of-life; the Hospital Anxiety and Depression scale; the PCL-5 to assess Posttraumatic Stress; and the Posttraumatic Growth Inventory. The datasets were integrated during analysis.<br><br>RESULTS: 96 useable survey responses were received. A clinical level of depression was reported by 29 participants (30.21%), of anxiety by 48 (50%), of posttraumatic distress disorder by 32 (33.33%), and of posttraumatic growth by 34 (35.42%). Carers had worse scores than patients. Three main themes were developed from interviews with 10 patients and 11 carers: 'Prognosis', 'Support from services', and 'Social connections and communication'.<br><br>CONCLUSIONS: Healthcare professionals delivering a mesothelioma diagnosis require regular training in communication skills plus updating in current treatment options, so they provide an appropriate mix of realism and hope. Better signposting to mental health support is needed for patients and carers. Our introduction of posttraumatic growth into the mesothelioma literature is novel. We recommend specialist nurses are trained to recognise, understand, and foster posttraumatic growth.},
}
@article {pmid38521202,
year = {2024},
author = {Gill, RR and Nowak, AK and Giroux, DJ and Eisele, M and Rosenthal, A and Kindler, H and Wolf, A and Ripley, RT and Billé, A and Rice, D and Opitz, I and Rimner, A and de Perrot, M and Pass, HI and Rusch, VW and , },
title = {The International Association for the Study of Lung Cancer Mesothelioma Staging Project: Proposals for Revisions of the "T" Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Pleural Mesothelioma.},
journal = {Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
volume = {19},
number = {9},
pages = {1310-1325},
pmid = {38521202},
issn = {1556-1380},
support = {P30 CA008748/CA/NCI NIH HHS/United States ; },
mesh = {Humans ; *Neoplasm Staging/standards/methods ; *Pleural Neoplasms/pathology/classification ; *Lung Neoplasms/pathology/classification ; Male ; Female ; *Mesothelioma/pathology/classification ; Aged ; Middle Aged ; Mesothelioma, Malignant/pathology/classification ; Prognosis ; Prospective Studies ; },
abstract = {INTRODUCTION: The primary tumor (T) component in the eighth edition of pleural mesothelioma (PM) staging system is based on pleural involvement and extent of invasion. Quantitative assessment of pleural tumor has been found to be prognostic. We explored quantitative and qualitative metrics to develop recommendations for T descriptors in the upcoming ninth edition of the PM staging system.<br><br>METHODS: The International Association for the Study of Lung Cancer prospectively collected data on patients with PM. Sum of maximum pleural thickness (Psum) was recorded. Optimal combinations of Psum and eighth edition cT descriptors were assessed using recursive binary splitting algorithm, with bootstrap resampling to correct for the adaptive nature of the splitting algorithm, and validated in the eighth edition data. Overall survival (OS) was calculated by the Kaplan-Meier method and differences in OS assessed by the log-rank test.<br><br>RESULTS: Of 7338 patients submitted, 3598 were eligible for cT analysis and 1790 had Psum measurements. Recursive partitioning identified optimal cutpoints of Psum at 12 and 30 mm, which, in combination with extent of invasion, yielded four prognostic groups for OS. Fmax greater than 5 mm indicated poor prognosis. cT4 category (based on invasion) revealed similar performance to eighth edition. Three eighth edition descriptors were eliminated based on low predictive accuracy. Eighth edition pT descriptors remained valid in ninth edition analyses.<br><br>CONCLUSION: Given reproducible prognostication by Psum, size criteria will be incorporated into cT1 to T3 categories in the ninth edition. Current cT4 category and all pT descriptors will be maintained, with reclassification of fissural invasion as pT2.},
}
@article {pmid38515807,
year = {2023},
author = {Singh, S and Roy Pradhan, S and Yadav, A and Singh, PK},
title = {Banning asbestos in talcum powder: Time for action in India.},
journal = {Dialogues in health},
volume = {3},
number = {},
pages = {100158},
pmid = {38515807},
issn = {2772-6533},
abstract = {Long-term use of asbestos-contaminated talcum power has been reported to be the main causative agent for carcinogenesis in many research studies. In recent developments Johnson &amp; Johnson has lost multimillion-dollar lawsuits for being associated with the development of mesothelioma and ovarian cancer by its talc-based baby powder. In May 2020, the company announced, the end of the sale of its baby powder in the USA and Canada and in August 2022, announced the global discontinuation by 2023. However, in India vast proportions of people are using talc-based baby powder and the products are readily available in the market. The purpose of this communication is to create awareness and draw attention of authorities for effective regulation, including prohibition of sale and retraction of the contaminated talc-based products from the Indian market at the earliest.},
}
@article {pmid38511037,
year = {2024},
author = {Singh, A and Bansal, C and Singla, D and More, S and Chabhra, S and Bashir, S},
title = {Peritoneal Malignant Mesothelioma Metastasizing to Lymph Node in Young Male-a Case Report.},
journal = {Indian journal of surgical oncology},
volume = {15},
number = {1},
pages = {145-148},
pmid = {38511037},
issn = {0975-7651},
abstract = {Peritoneal malignant mesothelioma is an uncommon neoplasm with a poor prognosis. We hereby report a case of a 20-year-old male, first diagnosed on biopsy with axillary lymph node metastasis. He presented with abdominal pain and axillary lymphadenopathy, with no history of asbestos exposure. CECT showed peritoneal thickening and ascites. Ascitic fluid cytology showed reactive morphology. The diagnosis of metastatic deposits of malignant mesothelioma was made on histopathology and confirmed by immunohistochemistry. Tumor cells were immune-reactive for CK 5/6, calretinin, D2-40, and WT1 and negative for TTF1, CK 20, and CD 3. This case report has two important highlights-(i) unusual presentation with axillary lymph node metastasis leading to diagnostic dilemma in a young male with no asbestos exposure history and (ii) confirmatory diagnostic role of IHC in Peritoneal malignant mesothelioma.},
}
@article {pmid38505910,
year = {2024},
author = {Tuncel, T and Ak, G and Güneş, HV and Metintaş, M},
title = {Complex Genomic Rearrangement Patterns in Malignant Pleural Mesothelioma due to Environmental Asbestos Exposure.},
journal = {Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer},
volume = {43},
number = {2},
pages = {13-27},
doi = {10.1615/JEnvironPatholToxicolOncol.2023046200},
pmid = {38505910},
issn = {2162-6537},
mesh = {Humans ; *Mesothelioma, Malignant/genetics/complications ; *Mesothelioma/chemically induced/genetics ; *Lung Neoplasms/chemically induced/genetics ; *Asbestos/toxicity ; Genomics ; Nucleotides ; Xeroderma Pigmentosum Group D Protein ; X-ray Repair Cross Complementing Protein 1 ; DEAD-box RNA Helicases ; },
abstract = {Malignant pleural mesothelioma (MPM) is a rare type of cancer, and its main risk factor is exposure to asbestos. Accordingly, our knowledge of the genomic structure of an MPM tumor is limited when compared to other cancers. In this study, we aimed to characterize complex genomic rearrangement patterns and variations to better understand the genomics of MPM tumors. We comparatively scanned 3 MPM tumor genomes by Whole-Genome Sequencing and High-Resolution SNP array. We also used various computational algorithms to detect both CNAs and complex chromosomal rearrangements. Genomic data obtained from each bioinformatics tool are interpreted comparatively to better understand CNAs and cancer-related Nucleotide variations in MPM tumors. In patients 1 and 2, we found pathogenic nucleotide variants of BAP1, RB1, and TP53. These two MPM genomes exhibited a highly rearranged chromosomal rearrangement pattern resembling Chromomanagesis particularly in the form of Chromoanasynthesis. In patient 3, we found nucleotide variants of important cancer-related genes, including TGFBR1, KMT2C, and PALLD, to have lower chromosomal rearrangement complexity compared with patients 1 and 2. We also detected several actionable nucleotide variants including XRCC1, ERCC2. We also discovered the SKA3-DDX10 fusion in two MPM genomes, which is a novel finding for MPM. We found that MPM genomes are very complex, suggesting that this highly rearranged pattern is strongly related to driver mutational status like BAP1, TP53 and RB1.},
}
@article {pmid38502527,
year = {2024},
author = {Rota, M and Viscardi, A and Maghin, F and Placidi, D and Conti, A},
title = {Mesothelioma among seamen: a systematic review and meta-analysis.},
journal = {European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)},
volume = {33},
number = {5},
pages = {438-447},
doi = {10.1097/CEJ.0000000000000875},
pmid = {38502527},
issn = {1473-5709},
mesh = {Humans ; *Mesothelioma/epidemiology/mortality/etiology ; *Occupational Exposure/adverse effects ; *Asbestos/adverse effects/toxicity ; *Ships ; Occupational Diseases/epidemiology/etiology/mortality ; Military Personnel/statistics &amp; numerical data ; },
abstract = {OBJECTIVES: Navy personnel and seafarers live and work 24 h per day in the shipboard environment and they are exposed to asbestos fibers released into the confined spaces aboard ships. We conducted a systematic review and meta-analysis to quantify the mesothelioma risk of seamen working aboard ships, either commercial or naval vessels, as compared to that of the general population.<br><br>METHODS: We carried out a literature search in MEDLINE through PubMed and EMBASE, from inception to 31 December 2021, of all studies on seamen working aboard ships, either commercial or naval vessels, characterized by exposure to asbestos and providing mesothelioma risk estimates. The Newcastle-Ottawa Scale was used to assess the quality of the studies included. The pooled standardized mortality ratio (SMR) was computed across eligible studies. The study protocol was registered on PROSPERO and reporting followed the preferred reporting items for systematic reviews and meta-analyses guidelines.<br><br>RESULTS: A total of 10 studies published from 1990 to 2020 were considered eligible and included in the systematic review and meta-analysis. All the included studies were of good quality, with a median score of seven out of nine. Overall, there were 235 mesothelioma cases/deaths in the included studies versus 115.6 expected, with a pooled SMR of 2.11 (95% confidence intervals, 1.70-2.62), in the absence of a significant between-study heterogeneity (I2 &#x2005;=&#x2005;39%, P &#x2005;=&#x2005;0.11).<br><br>CONCLUSION: A more than double excess risk for mesothelioma among seamen working aboard ships emerged from our meta-analysis.},
}
@article {pmid38502172,
year = {2024},
author = {Dodson, RF and Moline, J and Salinas, CD and Poye, LW},
title = {Elongated particulate burden in an individual who died of mesothelioma and had an occupational history as a talc "mucker".},
journal = {Inhalation toxicology},
volume = {36},
number = {3},
pages = {205-216},
doi = {10.1080/08958378.2024.2329935},
pmid = {38502172},
issn = {1091-7691},
mesh = {Male ; Humans ; Aged ; Talc ; *Mesothelioma/chemically induced ; Asbestos, Amphibole ; *Mesothelioma, Malignant/complications ; *Asbestos/toxicity ; *Lung Neoplasms/chemically induced ; Dust ; },
abstract = {INTRODUCTION: Tissue from a 77-year-old man diagnosed with mesothelioma was referred with a request for identification of the presence of fibrous structures in tissue samples. The individual's work history including working as a "mucker" at a specific "industrial" talc mine.<br><br>METHODS: Ferruginous bodies in the tissue digests as well as asbestos fibers were found. A bulk sample of a talc containing product from that mine was also analyzed.<br><br>DISCUSSIONS/CONCLUSIONS: The correlation between the unique asbestos mineral/fibrous content of the talc to which he was exposed and findings of the same type of asbestos found in his lung is discussed. The type of asbestos found (tremolite) is a "non-commercial" type of asbestos that has been identified in some talc deposits. Tremolite, like all forms of asbestos is a causative agent for mesothelioma-the disease from which this individual suffered.},
}
@article {pmid38500093,
year = {2024},
author = {Miao, X and Yao, T and Dong, C and Chen, Z and Wei, W and Shi, Z and Xu, T and Shao, J and Niu, Q and Rui, D and Hu, Y and Yan, Y},
title = {Global, regional, and national burden of non-communicable diseases attributable to occupational asbestos exposure 1990-2019 and prediction to 2035: worsening or improving?.},
journal = {BMC public health},
volume = {24},
number = {1},
pages = {832},
pmid = {38500093},
issn = {1471-2458},
support = {RCZK2021B28//The Shihezi University High-level Talents Program/ ; ZZZC202125//The Shihezi University self-funded project/ ; SRP2023085//The Shihezi University 2023 College Student Research and Training Program SRP Project/ ; },
mesh = {Male ; Humans ; Aged ; Quality-Adjusted Life Years ; *Noncommunicable Diseases/epidemiology ; Global Burden of Disease ; *Occupational Exposure/adverse effects ; *Asbestos/toxicity ; Global Health ; },
abstract = {Understanding the burden associated with occupational asbestos exposure on a global and regional scale is necessary to implement coordinated prevention and control strategies. By the GBD Study 2019, we conducted a comprehensive assessment of the non-communicable diseases burden attributable to occupational asbestos exposure. In 2019, 239,330 deaths and 4,189,000 disability-adjusted life years (DALYs) worldwide due to occupational asbestos exposure occurred. 1990-2019, deaths and DALYs attributed to occupational asbestos exposure increased by 65.65% and 43.66%, respectively. Age-standardized mortality rate (ASMR) and age-standardized DALYs rate (ASDR) decreased, with the most rapid declines in high Socio-Demographic Index (SDI) regions, with average annual percent change (AAPC) of - 1.05(95%CI: -1.2, -0.89) and -1.53(95%CI: -1.71, -1.36), respectively. Lung cancer, mesothelioma and ovarian cancer were the top three contributors to the increase in deaths and DALYs, accounting for more than 96%. AAPCs of ASMR and ASDR were positively associated with SDI. Global deaths from occupational asbestos exposure were predicted to increase and ASMR to decrease by 2035, mostly in males. Due consideration should be given to the susceptibility of the elderly, the lag of asbestos onset, and the regional differences, and constantly improve the prevention and control measures of occupational asbestos exposure and related diseases.},
}
@article {pmid38490630,
year = {2024},
author = {Frank, AL},
title = {To the Editor-environmental research this letter is a critique of the paper by regarding chronological trends of the fiber burden in mesothelioma cases.},
journal = {Environmental research},
volume = {251},
number = {Pt 1},
pages = {117352},
doi = {10.1016/j.envres.2023.117352},
pmid = {38490630},
issn = {1096-0953},
mesh = {Humans ; *Mesothelioma/epidemiology ; Asbestos ; },
}
@article {pmid38482789,
year = {2024},
author = {Chellini, E},
title = {[Is the epidemiological surveillance of malignant mesothelioma implemented in Italy still valid and necessary?].},
journal = {Epidemiologia e prevenzione},
volume = {48},
number = {1},
pages = {78-84},
doi = {10.19191/EP24.1.A561.024},
pmid = {38482789},
issn = {1120-9763},
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/epidemiology/etiology ; *Occupational Exposure ; *Pleural Neoplasms/epidemiology/etiology ; Italy/epidemiology ; *Asbestos/toxicity ; },
abstract = {The register of malignant mesotheliomas can still play an informative role in the context of both remediation activities and the health surveillance of former asbestos-exposed persons, and become an epidemiological surveillance system on the harmful effects of exposure to asbestos. It must, however, maintain and improve the level of quality achieved, resolve the problems that have emerged in the interaction between the local level (where cases and their exposure histories are identified, registered, assessed, and medical insurance procedures activated) and the central insurance body that also manages the national register, and become an active participant in research, including clinical research. All this is important to meet the social and welfare justice needs of individual cases.},
}
@article {pmid38465395,
year = {2024},
author = {Costantino, C and Ledda, C and Riccò, M and Costagliola, E and Balsamo, F and Belluzzo, M and Bonaccorso, N and Carubia, A and D'Azzo, L and Sciortino, M and Vitello, T and Zagra, L and Fruscione, S and Ilardo, S and Trapani, E and Calamusa, G and Rapisarda, V and Mazzucco, W},
title = {Decade-long insights: tracking asbestos-related health impacts among formerly exposed workers in Palermo, Italy.},
journal = {Annali di igiene : medicina preventiva e di comunita},
volume = {36},
number = {5},
pages = {525-536},
doi = {10.7416/ai.2024.2619},
pmid = {38465395},
issn = {1120-9135},
mesh = {Humans ; Italy/epidemiology ; *Occupational Exposure/adverse effects ; *Asbestosis/epidemiology/etiology ; *Asbestos/adverse effects ; Male ; *Lung Neoplasms/epidemiology/etiology ; Middle Aged ; Female ; Aged ; *Occupational Diseases/epidemiology/etiology ; Mesothelioma/epidemiology/etiology ; Adult ; Time Factors ; Pleural Neoplasms/epidemiology/etiology ; Smoking/epidemiology/adverse effects ; },
abstract = {BACKGROUND: Asbestos is a foremost occupational carcinogen globally. Despite the prohibition under Law 257/1992, Italy persists as one of the European nations most burdened by asbestos-related diseases (ARDs). This research assessed ARD cases in asbestos-exposed workers from the Province of Palermo, Italy, spanning 2010-2021.<br><br>METHODS: Data acquisition utilized the epidemiological dataset from the 'Service of Prevention and Safety on Work Environment' under the Prevention Department of Palermo's Local Health Authority (LHA).<br><br>RESULTS: Between 2010 and 2021, we identified 245 ARD instances, comprising 163 Asbestosis/Pleural plaques, 41 Lung Cancers, 38 Mesotheliomas, and 3 unspecified cases. Multivariate analysis indicated a notable decline in temporal exposure for mesothelioma (HR=0.933; 95% CI=0.902-0.965) and lung cancer (HR=0.93; 95% CI=0.90-0.978) relative to pleural plaques/asbestosis. Tobacco use displayed a pronounced correlation with lung cancer (smoker HR=64.520 95% CI=13,075-318.390; former smoker HR=20.917 95% CI=4,913-89.048). A significant link was observed between mesothelioma and pleural plaques/asbestosis in those employed in shipbuilding and repair (HR=0.371 95% CI=0.155-0.892).<br><br>CONCLUSIONS: ARDs persist in clinical observations, even following the 1992 cessation of asbestos-related activities, emphasizing an enduring public health challenge. Enhancing prevention strategies is paramount, focusing on amplifying anamnestic and occupational data collection, thereby facilitating superior early diagnosis strategies for these maladies in the occupationally exposed cohort.},
}
@article {pmid38462627,
year = {2024},
author = {Liu, J and Lu, Y and Liu, Y and Zhang, W and Xian, S and Wang, S and Zheng, Z and Lin, R and Jin, M and Zhang, M and Qian, W and Tang, J and Lu, B and Yang, Y and Liu, Z and Qu, M and Ma, H and Wu, X and Chang, Z and Zhang, J and Zhang, Y},
title = {A gene signature linked to fibroblast differentiation for prognostic prediction of mesothelioma.},
journal = {Cell &amp; bioscience},
volume = {14},
number = {1},
pages = {33},
pmid = {38462627},
issn = {2045-3701},
support = {82002923//National Natural Science Foundation of China/ ; 201940306//Shanghai Municipal Health Commission/ ; },
abstract = {BACKGROUND: Malignant mesothelioma is a type of infrequent tumor that is substantially related to asbestos exposure and has a terrible prognosis. We tried to produce a fibroblast differentiation-related gene set for creating a novel classification and prognostic prediction model of MESO.<br><br>METHOD: Three databases, including NCBI-GEO, TCGA, and MET-500, separately provide single-cell RNA sequencing data, bulk RNA sequencing profiles of MESO, and RNA sequencing information on bone metastatic tumors. Dimensionality reduction and clustering analysis were leveraged to acquire fibroblast subtypes in the MESO microenvironment. The fibroblast differentiation-related genes (FDGs), which were associated with survival and subsequently utilized to generate the&#xa0;MESO categorization and prognostic prediction model, were selected in combination with pseudotime analysis and survival information from the TCGA database. Then, regulatory network was constructed for each MESO subtype, and candidate inhibitors were predicted. Clinical specimens were collected for further validation.<br><br>RESULT: A total of six fibroblast subtypes, three differentiation states, and 39 FDGs were identified. Based on the expression level of FDGs, three MESO subtypes were distinguished in the fibroblast differentiation-based classification&#xa0;(FDBC). In the multivariate prognostic prediction model, the risk score that was dependent on the expression level of several&#xa0;important FDGs,&#xa0;was verified to be an independently effective prognostic factor and worked well in internal cohorts. Finally, we predicted 24 potential drugs for the treatment of MESO. Moreover, immunohistochemical staining and statistical analysis provided further validation.<br><br>CONCLUSION: Fibroblast differentiation-related genes&#xa0;(FDGs), especially those in low-differentiation states, might&#xa0;participate in the proliferation and invasion of MESO. Hopefully, the raised clinical subtyping of MESO would provide references for clinical practitioners.},
}
@article {pmid38459714,
year = {2024},
author = {Rigon, M and Mutti, L and Campanella, M},
title = {Pleural mesothelioma (PMe): The evolving molecular knowledge of a rare and aggressive cancer.},
journal = {Molecular oncology},
volume = {18},
number = {4},
pages = {797-814},
pmid = {38459714},
issn = {1878-0261},
support = {2019//Gruppo Italiano Mesotelioma G.I.Me Charity/ ; COG2018-819600_FIRM//H2020 European Research Council/ ; ARCLEADER2022020004901//Fondation ARC pour la Recherche sur le Cancer/ ; MFAG21903//Associazione Italiana per la Ricerca sul Cancro/ ; },
mesh = {Humans ; *Mesothelioma/genetics/diagnosis ; *Mesothelioma, Malignant ; *Pleural Neoplasms/genetics ; *Asbestos ; *Lung Neoplasms/pathology ; },
abstract = {Mesothelioma is a type of late-onset cancer that develops in cells covering the outer surface of organs. Although it can affect the peritoneum, heart, or testicles, it mainly targets the lining of the lungs, making pleural mesothelioma (PMe) the most common and widely studied mesothelioma type. PMe is caused by exposure to fibres of asbestos, which when inhaled leads to inflammation and scarring of the pleura. Despite the ban on asbestos by most Western countries, the incidence of PMe is on the rise, also facilitated by a lack of specific symptomatology and diagnostic methods. Therapeutic options are also limited to mainly palliative care, making this disease untreatable. Here we present an overview of biological aspects underlying PMe by listing genetic and molecular mechanisms behind its onset, aggressive nature, and fast-paced progression. To this end, we report on the role of deubiquitinase BRCA1-associated protein-1 (BAP1), a tumour suppressor gene with a widely acknowledged role in the corrupted signalling and metabolism of PMe. This review aims to enhance our understanding of this devastating malignancy and propel efforts for its investigation.},
}
@article {pmid38447601,
year = {2024},
author = {Roggli, VL and Pavlisko, EN and Glass, CH and Green, CL and Liu, B and Carney, JM},
title = {Response to the editor-Environmental Research this letter is a critique of the paper by Roggli et al. (1) regarding chronological trends of the fiber burden in mesothelioma cases.},
journal = {Environmental research},
volume = {251},
number = {Pt 1},
pages = {118620},
doi = {10.1016/j.envres.2024.118620},
pmid = {38447601},
issn = {1096-0953},
mesh = {Humans ; *Mesothelioma/epidemiology/chemically induced ; Asbestos ; },
}
@article {pmid38447379,
year = {2024},
author = {Haakensen, VD and Öjlert, &#xc5;K and Thunold, S and Farooqi, S and Nowak, AK and Chin, WL and Grundberg, O and Szejniuk, WM and Cedres, S and Sørensen, JB and Dalen, TS and Lund-Iversen, M and Bjaanæs, M and Helland, &#xc5;},
title = {UV1 telomerase vaccine with ipilimumab and nivolumab as second line treatment for pleural mesothelioma - A phase II randomised trial.},
journal = {European journal of cancer (Oxford, England : 1990)},
volume = {202},
number = {},
pages = {113973},
doi = {10.1016/j.ejca.2024.113973},
pmid = {38447379},
issn = {1879-0852},
mesh = {Humans ; Nivolumab/adverse effects ; Ipilimumab/adverse effects ; *Telomerase ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; *Mesothelioma, Malignant/drug therapy ; *Mesothelioma/drug therapy ; *Pleural Neoplasms/drug therapy/etiology ; },
abstract = {PURPOSE: The NIPU-trial investigates the effect of adding the telomerase vaccine UV1 to treatment with ipilimumab and nivolumab for patients with pleural mesothelioma (PM).<br><br>METHODS: In this phase 2 open-label trial, patients with PM progressing after first-line chemotherapy were randomised to receive ipilimumab and nivolumab alone (arm B) or combined with UV1 (arm A). The primary endpoint was progression-free survival (PFS) as determined by BICR. It was estimated that 69 PFS events were needed to detect a hazard ratio (HR) of 0.60 with 80% power and a one-sided alpha level of 0.10.<br><br>RESULTS: 118 patients were randomised. The median PFS determined by blinded independent central review (BICR) was 4.2 months (95%CI 2.9-9.8) in arm A and 4.7 months (95%CI 3.9-7.0) in arm B (HR 1.01, 80%CI 0.75-1.36&#xa0;P&#xa0;=&#xa0;0.979), after a median follow-up of 12.5 months (95%CI 9.7-15.6). The investigator-determined median PFS was 4.3 months (95%CI 3.0-6.8) in arm A and 2.9 months (95%CI 2.4-5.5) in arm B (HR 0.60, 80%CI 0.45-0.81&#xa0;P&#xa0;=&#xa0;0.025). Confirmed objective response rate (ORR) by BICR was 31% in arm A and 16% in arm B (odds ratio 2.44 80%CI 1.35-4.49&#xa0;P&#xa0;=&#xa0;0.056). After a median follow-up time of 17.3 months (95%CI 15.8-22.9), the OS was 15.4 months (95%CI 11.1-22.6) in arm A and 11.1 months (95%CI 8.8-18.1) in arm B, (HR 0.73, 80%CI 0.53-1.0, P&#xa0;=&#xa0;0.197).<br><br>CONCLUSION: The primary endpoint was not met. Predefined analyses of response rates are in favour of adding the vaccine.},
}
@article {pmid38426158,
year = {2024},
author = {Amakusa, Y and Suzuki, T and Hikosaka, Y and Takemura, M and Oguri, T},
title = {Successful treatment of simultaneous malignant pleural mesothelioma and pulmonary adenocarcinoma: A case report.},
journal = {Oncology letters},
volume = {27},
number = {4},
pages = {155},
pmid = {38426158},
issn = {1792-1082},
abstract = {The present report described the case of a 74-year-old male patient with asbestos exposure whose chest computed tomography revealed a right lower lobe nodule and right pleural effusion. Pleural biopsy led to the diagnosis of epithelial malignant pleural mesothelioma (cT2N0M0, stage IB). Combination therapy with cisplatin + pemetrexed led to the complete remission of malignant pleural mesothelioma; however, the right lower lobe nodule grew in size over time. The patient was subsequently diagnosed with lung adenocarcinoma (cT1aN0M0, stage IA1) by computed tomography-guided biopsy performed 18 months after chemotherapy initiation and achieved remission of lung adenocarcinoma with stereotactic radiotherapy. The patient was alive without recurrence at the 12-month follow-up. The present case illustrated that multiple active regimens are currently available for malignant pleural mesothelioma and lung cancer that can aid in the treatment of complex cases.},
}
@article {pmid38423601,
year = {2024},
author = {Shimizu, D and Ishibashi, M and Yamada, T and Toda, Y and Hosogi, S and Ashihara, E},
title = {POLD1 Is Required for Cell Cycle Progression by Overcoming DNA Damage in Malignant Pleural Mesothelioma.},
journal = {Cancer genomics &amp; proteomics},
volume = {21},
number = {2},
pages = {158-165},
pmid = {38423601},
issn = {1790-6245},
mesh = {Humans ; *Mesothelioma, Malignant ; DNA Polymerase III/genetics ; *Lung Neoplasms/pathology ; *Pleural Neoplasms/genetics/pathology ; *Mesothelioma/genetics ; RNA, Small Interfering/genetics ; Cell Line, Tumor ; Cell Cycle/genetics ; DNA Damage ; RNA, Messenger ; },
abstract = {BACKGROUND/AIM: The prognosis of patients with malignant pleural mesothelioma (MPM) remains poor due to lack of effective therapeutic targets. DNA damage caused by long-time exposure to asbestos fibers has been associated with the development of MPM, with mutations at genes encoding DNA damage repair (DDR)-related molecules frequently expressed in patients with MPM. The present study was designed to identify novel therapeutic targets in MPM using large public databases, such as The Cancer Genome Atlas (TCGA) and Genotype Tissue Expression project (GTEx) focused on DDR pathways.<br><br>MATERIALS AND METHODS: The correlations between mRNA expression levels of DDR-related genes and overall survival (OS) were analyzed in mesothelioma patients in TCGA mesothelioma (TCGA-MESO) datasets. The anti-tumor effects of small interfering RNAs (siRNA) against DDR-related genes associated with OS were subsequently tested in MPM cell lines.<br><br>RESULTS: High levels of mRNA encoding DNA polymerase delta 1, catalytic subunit (POLD1) were significantly associated with reduced OS in patients with MPM (p<0.001, Log-rank test). In addition, siRNA targeting POLD1 (siPOLD1) caused cell cycle arrest at the G1/S checkpoint and induced apoptosis involving accumulation of DNA damage in MPM cell lines.<br><br>CONCLUSION: POLD1 plays essential roles in overcoming DNA damage and cell cycle progression at the G1/S checkpoint in MPM cells. These findings suggest that POLD1 may be a novel therapeutic target in MPM.},
}
@article {pmid38413635,
year = {2024},
author = {Elkahwagy, DM and Kiriacos, CJ and Sobeih, ME and Khorshid, OMR and Mansour, M},
title = {The lncRNAs Gas5, MALAT1 and SNHG8 as diagnostic biomarkers for epithelial malignant pleural mesothelioma in Egyptian patients.},
journal = {Scientific reports},
volume = {14},
number = {1},
pages = {4823},
pmid = {38413635},
issn = {2045-2322},
mesh = {Humans ; Biomarkers ; Biomarkers, Tumor/genetics ; Egypt ; *Mesothelioma/diagnosis/genetics ; *Mesothelioma, Malignant ; *RNA, Long Noncoding/genetics ; },
abstract = {Long noncoding RNAs have been shown to be involved in a myriad of physiological and pathological pathways. To date, malignant pleural mesothelioma (MPM) is considered an extremely aggressive cancer. One reason for this is the late diagnosis of the disease, which can occur within 30-40 years of asbestos exposure. There is an immense need for the development of new, sensitive, inexpensive and easy methods for the early detection of this disease other than invasive methods such as biopsy. The aim of this study was to determine the expression of circulating lncRNAs in mesothelioma patient plasma to identify potential biomarkers. Ten previously identified lncRNAs that were shown to be aberrantly expressed in mesothelioma tissues were selected as candidates for subsequent validation. The expression of the ten selected candidate lncRNAs was verified via quantitative PCR (qPCR) in human plasma samples from mesothelioma patients versus healthy controls. The expression levels of circulating GAS5, SNHG8 and MALAT1 were significantly greater in plasma samples from patients than in those from controls. The ROC analysis of both MALAT1 and SNHG8 revealed 88.89% sensitivity and 66.67% specificity. The sensitivity of these markers was greater than that of GAS5 (sensitivity 72.22% and specificity 66.67%). The regression model for GAS5 was statistically significant, while that for SNHG8 and MALAT1 was not significant due to the small sample size. The area under the curve (AUC) of the three ROC curves was acceptable and significant: 0.7519 for GAS5, 0.7352 for SNHG8 and 0.7185 for MALAT1. This finding confirmed their ability to be used as markers. The three lncRNAs were not affected by age, sex or smoking status. The three lncRNAs showed great potential as independent predictive diagnostic biomarkers. Although the prediction model for MALAT1 did not significantly differ, MALAT1 was significantly expressed in patients more than in controls (p = 0.0266), and the recorded sensitivity and specificity were greater than those of GAS5.},
}
@article {pmid38412661,
year = {2024},
author = {Kalla, C and Ott, G and Finotello, F and Niewola-Staszkowska, K and Conza, GD and Lahn, M and van der Veen, L and Schüler, J and Falkenstern-Ge, R and Kopecka, J and Riganti, C},
title = {The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition.},
journal = {Translational oncology},
volume = {43},
number = {},
pages = {101857},
pmid = {38412661},
issn = {1936-5233},
abstract = {Targeting aberrantly expressed kinases in malignant pleural mesothelioma (MPM) is a promising therapeutic strategy. We here investigated the effect of the novel and highly selective Phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib (IOA-244) on MPM cells and on the immune cells in MPM microenvironment. To this aim, we analyzed the expression of PI3K-δ by immunohistochemistry in specimens from primary MPM, cell viability and death in three different MPM cell lines treated with roginolisib alone and in combination with ipatasertib (AKT inhibitor) and sapanisertib (mTOR inhibitor). In a co-culture model of patient-derived MPM cells, autologous peripheral blood mononuclear cells and fibroblasts, the tumor cell viability and changes in immune cell composition were investigated after treatment of roginolisib with nivolumab and cisplatin. PI3K-δ was detected in 66/89 (74%) MPM tumors and was associated with reduced overall survival (12 vs. 25 months, P=0.0452). Roginolisib induced apoptosis in MPM cells and enhanced the anti-tumor efficacy of AKT and mTOR kinase inhibitors by suppressing PI3K-δ/AKT/mTOR and ERK1/2 signaling. Furthermore, the combination of roginolisib with chemotherapy and immunotherapy re-balanced the immune cell composition, increasing effector T-cells and reducing immune suppressive cells. Overall, roginolisib induces apoptosis in MPM cells and increases the antitumor immune cell effector function when combined with nivolumab and cisplatin. These results provide first insights on the potential of roginolisib as a therapeutic agent in patients with MPM and its potential in combination with established immunotherapy regimen.},
}
@article {pmid38410609,
year = {2024},
author = {Congedo, MT and West, EC and Evangelista, J and Mattingly, AA and Calabrese, G and Sassorossi, C and Nocera, A and Chiappetta, M and Flamini, S and Abenavoli, L and Margaritora, S and Boccuto, L and Lococo, F},
title = {The genetic susceptibility in the development of malignant pleural mesothelioma: somatic and germline variants, clinicopathological features and implication in practical medical/surgical care: a narrative review.},
journal = {Journal of thoracic disease},
volume = {16},
number = {1},
pages = {671-687},
pmid = {38410609},
issn = {2072-1439},
abstract = {BACKGROUND AND OBJECTIVE: Malignant pleural mesothelioma (MPM) is a very aggressive primary tumor of the pleura whose main risk factor is exposure to asbestos. However, only a minority of exposed people develops MPM and the incidence of MPM cases without an apparent association with asbestos exposure has been increasing in recent years, suggesting that genetic predisposing factors may play a crucial role. In addition, several studies reported familial cases of MPM, suggesting that heredity may be an important and underestimated feature in MPM development. Several candidate genes have been associated with a predisposition to MPM and most of them play a role in DNA repair mechanisms: overall, approximately 20% of MPM cases may be related to genetic predisposition. A particular category of patients with high susceptibility to MPM is represented by carriers of pathogenic variants in the BAP1 gene. Germline variants in BAP1 predispose to the development of MPM following an autosomal dominant pattern of inheritance in the familial cases. MPMs in these patients are significantly less aggressive, and patients require a multidisciplinary approach that involves genetic counseling, medical genetics, pathology, surgical, medical, and radiation oncology expertise. In the present narrative review, we presented a comprehensive overview of genetic susceptibility in the development of MPM.<br><br>METHODS: The narrative review is based on a selective literature carried out in PubMed in 2023. Inclusion criteria were original articles in English language, and clinical trials (randomized, prospective, or retrospective).<br><br>KEY CONTENT AND FINDINGS: We summarized the somatic and germline variants and the differences in terms of clinicopathological features and prognosis between gene-related MPM (GR-MPM) and asbestos-related MPM (AR-MPM). We also discussed the indications for screening, genetic testing, and surveillance of patients with BAP1 germline variants.<br><br>CONCLUSIONS: In this narrative review, we have emphasized that the BAP1 gene's harmful germline variations are inherited in an autosomal dominant manner in familial cases. MPMs in individuals with these variations are less severe, and their medical care necessitates a collaborative effort. Additionally, we have outlined the current therapeutic prospects for MPM, including the possibility of gene-specific therapy, which is currently promising but still requires clinical validation.},
}
@article {pmid38409016,
year = {2024},
author = {Nazar, T and Gopalakrishnabhaktan, A and Tashrifwala, FAA and Sathish, A and Dave, T},
title = {Testicular mesothelioma disguised as hydrocele: a case report.},
journal = {Journal of medical case reports},
volume = {18},
number = {1},
pages = {114},
pmid = {38409016},
issn = {1752-1947},
mesh = {Male ; Humans ; Middle Aged ; *Mesothelioma, Malignant/complications ; *Mesothelioma/diagnostic imaging/surgery ; *Testicular Hydrocele/diagnosis/surgery/etiology ; *Testicular Neoplasms/diagnosis/surgery/complications ; },
abstract = {BACKGROUND: Testicular tumors have many different manifestations. The majority of these cases are presented as an incidental finding during hydrocelectomy. Malignant mesotheliomas are uncommon tumours that can arise from the coelomic epithelium of the pleura, peritoneum, pericardium, and tunica vaginalis.<br><br>CASE PRESENTATION: We present a 51-year-old South Asian (Indian) male patient with a rare case of mesothelioma, presenting with right hydrocele, to whom a right hydrocelectomy was performed. Any history of trauma or asbestos exposure was not present. Histopathological and immunohistochemistry reports revealed a malignant mesothelioma of tunica vaginalis. There was no invasion of the tumour to the epididymis and spermatic cord. Imaging studies showed no signs of metastasis. 1&#xa0;month later, a high inguinal orchidectomy was performed. The patient underwent adjuvant chemotherapy thereafter and is still on follow-up.<br><br>CONCLUSION: Although hydrocele is common, detailed evaluation is mandatory to rule out certain rare tumours-testicular and paratesticular variants.},
}
@article {pmid38406142,
year = {2024},
author = {Qasim, A and Allu, SVV and Schmidt, P and Parikh, HR and Moore, S and Yapor, L and Soliman, M},
title = {Comprehensive Review of Mesothelioma Cases: From Diagnosis to Therapeutic Strategies.},
journal = {Cureus},
volume = {16},
number = {1},
pages = {e52859},
pmid = {38406142},
issn = {2168-8184},
abstract = {Mesothelioma is a rare and aggressive malignancy typically associated with asbestos exposure. We present the clinical and diagnostic journey of a 63-year-old male carpenter, who presented with concerning symptoms of shortness of breath and total right lung "white-out" on imaging. Comprehensive medical evaluation revealed the presence of malignant pleural mesothelioma. This study underscores the importance of considering mesothelioma as a potential diagnosis in individuals with occupational asbestos exposure and highlights patterns in diagnosing and managing this devastating disease. Early recognition and intervention are essential in improving outcomes for patients diagnosed with mesothelioma.},
}
@article {pmid38404135,
year = {2024},
author = {Barnes, H and Hoy, RF},
title = {Changing trends in mesothelioma: Important lessons for an occupational disease registry.},
journal = {Respirology (Carlton, Vic.)},
volume = {29},
number = {4},
pages = {269-270},
doi = {10.1111/resp.14692},
pmid = {38404135},
issn = {1440-1843},
mesh = {Humans ; *Mesothelioma/epidemiology/etiology ; *Mesothelioma, Malignant ; *Occupational Diseases/epidemiology ; Registries ; *Occupational Exposure/adverse effects ; *Asbestos/adverse effects ; *Pleural Neoplasms ; },
}
@article {pmid38402124,
year = {2024},
author = {Mukhopadhyay, D and Cocco, P and Orrù, S and Cherchi, R and De Matteis, S},
title = {The role of MicroRNAs as early biomarkers of asbestos-related lung cancer: A systematic review and meta-analysis.},
journal = {Pulmonology},
volume = {},
number = {},
pages = {},
doi = {10.1016/j.pulmoe.2024.02.002},
pmid = {38402124},
issn = {2531-0437},
abstract = {BACKGROUND: Asbestos is still the leading cause of occupational cancer mortality worldwide. Asbestos-related lung cancer (LC) and malignant pleural mesothelioma (MPM) prognosis is still poor especially at advanced stage, so early diagnosis biomarkers are needed. MicroRNAs (miRNAs) have been proposed as potential early diagnostic biomarkers of asbestos-related LC and MPM.<br><br>AIM: To evaluate the role of miRNAs as diagnostic and prognostic biomarkers of asbestos-related LC and MPM by performing a literature systematic review and meta-analysis.<br><br>METHODS: MEDLINE, EMBASE via Ovid, PUBMED and Cochrane library databases were systematically searched up to April 2023 to identify relevant articles. A grey literature search was also conducted using the Google Scholar platform. MeSH and free text terms for 'asbestos', 'occupational exposure', 'lung cancer', 'mesothelioma' and 'miRNAs' were used to search the literature. Our systematic review protocol was registered in the PROSPERO database. Study quality was assessed via the Newcastle-Ottawa Scale.<br><br>RESULTS: From the search, 331 articles were retrieved, and, after applying our selection criteria, and exclusion of one study for poor quality, 27 studies were included in the review. Most of the studies were hospital-based case-control, conducted in Europe, and evaluated MPM among men only. MiRNAs expression was measured mainly in plasma or serum. MiR-126, miR-132-3p, and miR-103a-3p were the most promising diagnostic biomarkers for MPM, and we estimated a pooled area under the curve (AUC) of 85 %, 73 %, and 50 %, respectively. In relation to MPM prognosis, miR-197&#x2011;3p resulted associated with increased survival time. MiR-126, alone and combined with miR-222, was confirmed associated also to LC diagnosis, together with miR-1254 and miR-574-5p; no miRNA was found associated to LC prognosis.<br><br>CONCLUSION: Based on our systematic literature review there is suggestive evidence that the expression of specific miRNAs in the blood serum or plasma are associated with asbestos-related LC and MPM diagnosis and prognosis. Further large longitudinal studies are urgently needed to validate these findings and elucidate the underlying mechanisms given the potential important implications for patients' survival.},
}
@article {pmid38397189,
year = {2024},
author = {Oliveto, S and Ritter, P and Deroma, G and Miluzio, A and Cordiglieri, C and Benvenuti, MR and Mutti, L and Raimondi, MT and Biffo, S},
title = {The Impact of 3D Nichoids and Matrix Stiffness on Primary Malignant Mesothelioma Cells.},
journal = {Genes},
volume = {15},
number = {2},
pages = {},
pmid = {38397189},
issn = {2073-4425},
support = {PRIN2020//PRIN/ ; WCR2022//WCR/ ; },
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/genetics/metabolism/pathology ; Collagen ; Cell Movement/genetics ; },
abstract = {Malignant mesothelioma is a type of cancer that affects the mesothelium. It is an aggressive and deadly form of cancer that is often caused by exposure to asbestos. At the molecular level, it is characterized by a low number of genetic mutations and high heterogeneity among patients. In this work, we analyzed the plasticity of gene expression of primary mesothelial cancer cells by comparing their properties on 2D versus 3D surfaces. First, we derived from primary human samples four independent primary cancer cells. Then, we used Nichoids, which are micro-engineered 3D substrates, as three-dimensional structures. Nichoids limit the dimension of adhering cells during expansion by counteracting cell migration between adjacent units of a substrate with their microarchitecture. Tumor cells grow effectively on Nichoids, where they show enhanced proliferation. We performed RNAseq analyses on all the samples and compared the gene expression pattern of Nichoid-grown tumor cells to that of cells grown in a 2D culture. The PCA analysis showed that 3D samples were more transcriptionally similar compared to the 2D ones. The 3D Nichoids induced a transcriptional remodeling that affected mainly genes involved in extracellular matrix assembly. Among these genes responsible for collagen formation, COL1A1 and COL5A1 exhibited elevated expression, suggesting changes in matrix stiffness. Overall, our data show that primary mesothelioma cells can be effectively expanded in Nichoids and that 3D growth affects the cells' tensegrity or the mechanical stability of their structure.},
}
@article {pmid38396947,
year = {2024},
author = {Okado, S and Kato, T and Hanamatsu, Y and Emoto, R and Imamura, Y and Watanabe, H and Kawasumi, Y and Kadomatsu, Y and Ueno, H and Nakamura, S and Mizuno, T and Takeuchi, T and Matsui, S and Chen-Yoshikawa, TF},
title = {CHST4 Gene as a Potential Predictor of Clinical Outcome in Malignant Pleural Mesothelioma.},
journal = {International journal of molecular sciences},
volume = {25},
number = {4},
pages = {},
pmid = {38396947},
issn = {1422-0067},
mesh = {Humans ; *Asbestos/toxicity ; Biomarkers, Tumor/genetics/metabolism ; *Mesothelioma, Malignant/diagnosis/genetics ; Survival Analysis ; },
abstract = {Malignant pleural mesothelioma (MPM) develops primarily from asbestos exposures and has a poor prognosis. In this study, The Cancer Genome Atlas was used to perform a comprehensive survival analysis, which identified the CHST4 gene as a potential predictor of favorable overall survival for patients with MPM. An enrichment analysis of favorable prognostic genes, including CHST4, showed immune-related ontological terms, whereas an analysis of unfavorable prognostic genes indicated cell-cycle-related terms. CHST4 mRNA expression in MPM was significantly correlated with Bindea immune-gene signatures. To validate the relationship between CHST4 expression and prognosis, we performed an immunohistochemical analysis of CHST4 protein expression in 23 surgical specimens from surgically treated patients with MPM who achieved macroscopic complete resection. The score calculated from the proportion and intensity staining was used to compare the intensity of CHST4 gene expression, which showed that CHST4 expression was stronger in patients with a better postoperative prognosis. The median overall postoperative survival was 107.8 months in the high-expression-score group and 38.0 months in the low-score group (p = 0.044, log-rank test). Survival after recurrence was also significantly improved by CHST4 expression. These results suggest that CHST4 is useful as a prognostic biomarker in MPM.},
}
@article {pmid38384604,
year = {2024},
author = {Bairos Menezes, M and Pedroso de Lima, R and Dunões, I and Inácio, M and Dinis, R},
title = {A Complete Response to Pembrolizumab in Malignant Peritoneal Mesothelioma: A Case Report.},
journal = {Cureus},
volume = {16},
number = {1},
pages = {e52716},
pmid = {38384604},
issn = {2168-8184},
abstract = {Malignant peritoneal mesothelioma (MPeM) is a rare cancer of the peritoneum with a poor prognosis and nonspecific clinical course. We discuss a case of MPeM in a 59-year-old male who presented with abdominal pain and distension, without any known previous asbestos exposure. The diagnosis was made after a second biopsy finally confirmed epithelioid MPeM in an advanced stage with pleural effusion. The patient underwent six cycles of chemotherapy with cisplatin and pemetrexed, experienced disease progression, and was then started on pembrolizumab as a second-line treatment. The patient achieved a complete response after two years of treatment with pembrolizumab and has been disease-free for almost four years with an Eastern Cooperative Oncology Group (ECOG) performance status of 0. Despite the lack of evidence to support the treatment with immunotherapy for MPeM, our case report encourages its use, highlighting its ability to enable a complete response with pembrolizumab with an excellent quality of life.},
}
@article {pmid38378028,
year = {2024},
author = {Mervic, A and Goricar, K and Blagus, T and Franko, A and Trebusak-Podkrajsek, K and Fikfak, MD and Dolzan, V and Kovac, V},
title = {Telomere length and TERT polymorphisms as biomarkers in asbestos-related diseases.},
journal = {Radiology and oncology},
volume = {58},
number = {1},
pages = {87-98},
pmid = {38378028},
issn = {1581-3207},
mesh = {Humans ; *Telomerase/genetics ; Case-Control Studies ; Retrospective Studies ; Polymorphism, Single Nucleotide ; Biomarkers ; Telomere/genetics ; Disease Progression ; },
abstract = {BACKGROUND: Asbestos exposure has been proposed as a risk factor for shorter telomere length. The aim of our study was to investigate whether telomere length in leukocytes and hTERT genetic polymorphisms may serve as potential biomarkers for the risk of developing asbestos-related diseases and as biomarkers of progression and chemotherapy response rate in malignant mesothelioma (MM).<br><br>SUBJECTS AND METHODS: We conducted two retrospective studies. In the first study, a case-control study, telomere length and hTERT polymorphisms were determined in patients with MM, subjects with pleural plaques and controls without the asbestos related disease, who were occupationally exposed to asbestos. In the second study, a longitudinal observational study, telomere length was also determined in samples from MM patients before and after chemotherapy. Telomere length was determined by monochromatic multiplex quantitative polymerase chain reaction (PCR), while competitive allele-specific PCR was used to genotype hTERT rs10069690, rs2736100 and rs2736098. Logistic regression and survival analysis were used in statistical analysis.<br><br>RESULTS: Patients with MM had shorter telomere length than subjects with pleural plaques (p < 0.001). After adjustment for age, rs2736098 CT, and rs10069690 TT and CT+TT genotypes were significantly associated with a higher risk of MM (padj = 0.023; padj = 0.026 and padj = 0.017), while rs2736100 AA and CA+AA genotypes conferred to a lower risk for MM compared to all other subjects (padj = 0.017, and padj = 0.026). Telomere length was not associated with a response to chemotherapy (p > 0.05) or time to disease progression (p > 0.05). Carriers of one or two polymorphic rs10069690 T alleles had a good response to chemotherapy (p = 0.039, and p = 0.048), these associations remained statistically significant after adjustment for age (padj = 0.019; padj = 0.017). Carriers of two polymorphic rs2736100 A alleles had a longer time to disease progression (p = 0.038).<br><br>CONCLUSIONS: Shorter telomere length and hTERT polymorphisms may serve as a biomarker for the risk of developing MM. Additionally, rs10069690 and rs2736100 polymorphisms, but not telomere length, were associated with a chemotherapy response or MM progression.},
}
@article {pmid38377382,
year = {2024},
author = {Tian, T and Xie, H and Huang, M},
title = {Epithelial Malignant Pleural Mesothelioma Mimics Lymphoma on 18 F-FDG PET/MRI : A Case Report.},
journal = {Clinical nuclear medicine},
volume = {49},
number = {4},
pages = {359-360},
doi = {10.1097/RLU.0000000000005095},
pmid = {38377382},
issn = {1536-0229},
mesh = {Male ; Humans ; Middle Aged ; *Mesothelioma, Malignant ; Fluorodeoxyglucose F18 ; *Lymphoma ; *Mesothelioma/diagnostic imaging ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; },
abstract = {Malignant pleural mesothelioma is a rare tumor with a poor prognosis. We describe a case of 55-year-old man without asbestos exposure history presenting with extensive lymph nodes with high 18 F-FDG uptake in PET/MRI but atypical pleural manifestations thereby being misdiagnosed for lymphoma. Pathological examination concludes for an epithelioid mesothelioma-associated lymph node metastasis. This case emphasizes that with the extensive lymph node abnormalities shown in PET imaging, in addition to the general consideration of lymphoma, it is still necessary to be vigilant about the possibility of mesothelioma and emphasizes the necessity of pathological examination.},
}
@article {pmid38350880,
year = {2024},
author = {Tilsed, CM and Morales, MLO and Zemek, RM and Gordon, BA and Piggott, MJ and Nowak, AK and Fisher, SA and Lake, RA and Lesterhuis, WJ},
title = {Tretinoin improves the anti-cancer response to cyclophosphamide, in a model-selective manner.},
journal = {BMC cancer},
volume = {24},
number = {1},
pages = {203},
pmid = {38350880},
issn = {1471-2407},
mesh = {Humans ; Animals ; Mice ; *Tretinoin/pharmacology/therapeutic use ; Cyclophosphamide ; CD8-Positive T-Lymphocytes ; Combined Modality Therapy ; *Mesothelioma/drug therapy ; Tumor Microenvironment ; },
abstract = {BACKGROUND: Chemotherapy is included in treatment regimens for many solid cancers, but when administered as a single agent it is rarely curative. The addition of immune checkpoint therapy to standard chemotherapy regimens has improved response rates and increased survival in some cancers. However, most patients do not respond to treatment and immune checkpoint therapy can cause severe side effects. Therefore, there is a need for alternative immunomodulatory drugs that enhance chemotherapy.<br><br>METHODS: We used gene expression data from cyclophosphamide (CY) responders and non-responders to identify existing clinically approved drugs that could phenocopy a chemosensitive tumor microenvironment (TME), and tested combination treatments in multiple murine cancer models.<br><br>RESULTS: The vitamin A derivative tretinoin was the top predicted upstream regulator of response to CY. Tretinoin pre-treatment induced an inflammatory, interferon-associated TME, with increased infiltration of CD8&#x2009;+&#x2009;T cells, sensitizing the tumor to subsequent chemotherapy. However, while combination treatment significantly improved survival and cure rate in a CD4[+] and CD8[+] T cell dependent manner in AB1-HA murine mesothelioma, this effect was model-selective, and could not be replicated using other cell lines.<br><br>CONCLUSIONS: Despite the promising data in one model, the inability to validate the efficacy of combination treatment in multiple cancer models deprioritizes tretinoin/cyclophosphamide combination therapy for clinical translation.},
}
@article {pmid38341199,
year = {2024},
author = {Mizuhashi, K and Okamoto, K and Nabeshima, K and Kishimoto, T},
title = {Detailed clinical course of a patient with rapidly progressing sarcomatoid pleural mesothelioma without p16 deletion with systemic haematogenous metastasis to soft tissues.},
journal = {BMJ case reports},
volume = {17},
number = {2},
pages = {},
pmid = {38341199},
issn = {1757-790X},
mesh = {Humans ; Male ; *Asbestos ; Disease Progression ; *Lung Neoplasms/pathology ; *Mesothelioma/diagnosis/genetics/pathology ; *Mesothelioma, Malignant ; *Pleural Effusion ; *Pleural Neoplasms/pathology ; Aged, 80 and over ; },
abstract = {Sarcomatoid mesothelioma is difficult to differentiate from other mesotheliomas. Here, we describe the case of a man in his early 80s with sarcomatoid mesothelioma and a history of asbestos exposure. He initially presented with right-sided chest pain and was examined. Right-sided pleural effusion was detected; therefore, he was hospitalised. Based on the observed pleural effusion and biopsy result, the presence of a malignant tumour was excluded; hence, he was diagnosed with benign asbestos pleurisy. He subsequently developed left-sided pleural effusion, masses and lung nodules, and died 9.5 months after the initial examination. A definitive diagnosis of sarcomatoid mesothelioma with rapid systemic progression was established after detailed investigations using autopsy specimens. This rare case of mesothelioma-without p16 deletion (detected using fluorescence in situ hybridisation)-presented differently from the usual sarcomatoid mesothelioma.},
}
@article {pmid38341059,
year = {2024},
author = {Xiong, X and Zhang, S and Liao, X and Du, J and Zheng, W and Hu, S and Wei, Q and Yang, L},
title = {An umbrella review of the evidence associating occupational carcinogens and cancer risk at 19 anatomical sites.},
journal = {Environmental pollution (Barking, Essex : 1987)},
volume = {345},
number = {},
pages = {123531},
doi = {10.1016/j.envpol.2024.123531},
pmid = {38341059},
issn = {1873-6424},
mesh = {Humans ; *Mesothelioma ; *Lung Neoplasms/chemically induced/epidemiology ; *Asbestos ; Carcinogens/toxicity ; *Occupational Exposure/adverse effects ; Formaldehyde/*adverse effects ; *Respiratory Hypersensitivity ; },
abstract = {Occupational exposure to carcinogens of increasing cancer risk have been extensively suggested. A robust assessment of these evidence is needed to guide public policy and health care. We aimed to classify the strength of evidence for associations of 13 occupational carcinogens (OCs) and risk of cancers. We searched PubMed and Web of Science up to November 2022 to identify potentially relevant studies. We graded the evidence into convincing, highly suggestive, suggestive, weak, or not significant according to a standardized classification based on: random-effects p value, number of cancer cases, 95% confidence interval of largest study, heterogeneity between studies, 95% prediction interval, small study effect, excess significance bias and sensitivity analyses with credibility ceilings. The quality of meta-analysis was evaluated by AMSTAR 2. Forty-eight articles yielded 79 meta-analyses were included in current umbrella review. Evidence of associations were convincing (class I) or highly suggeastive (class II) for asbestos exposure and increasing risk of lung cancer among smokers (RR = 8.79, 95%CI: 5.81-13.25 for cohort studies and OR = 8.68, 95%CI: 5.68-13.24 for case-control studies), asbestos exposure and increasing risk of mesothelioma (RR = 4.61, 95%CI: 2.57-8.26), and formaldehyde exposure and increasing risk of sinonasal cancer (RR = 1.68, 95%CI: 1.38-2.05). Fifteen associations were supported by suggestive evidence (class III). In summary, the current umbrella review found strong associations between: asbestos exposure and increasing risk of lung cancer among smokers; asbestos exposure and increasing risk of mesothelioma; and formaldehyde exposure and higher risk of sinonasal cancer. Other associations might be genuine, but substantial uncertainty remains.},
}
@article {pmid38323897,
year = {2024},
author = {Järvholm, B and Burdorf, A},
title = {Asbestos and disease - a public health success story?.},
journal = {Scandinavian journal of work, environment &amp; health},
volume = {50},
number = {2},
pages = {53-60},
pmid = {38323897},
issn = {1795-990X},
mesh = {Humans ; Public Health ; *Asbestos/adverse effects ; *Occupational Exposure/adverse effects/analysis ; *Neoplasms ; *Occupational Health ; *Mesothelioma/epidemiology ; *Lung Neoplasms/epidemiology ; *Asbestosis/epidemiology ; },
abstract = {OBJECTIVE: This paper discusses the failure and success of society to decrease the adverse health effects of asbestos exposure on workers' health in relation to scientific knowledge.<br><br>METHODS: The findings are based on a narrative literature review.<br><br>RESULTS: Early warnings of the adverse health effects of workplace exposure to asbestos were published already in the 1930s. Serious health effects, such as malignancies and fibrosis due to occupational asbestos exposure, were highlighted in major medical journals and textbooks in late 1960s. New technologies could detect also asbestos fibers in the lung of non-occupational exposed persons in the 1970s. The first bans for using asbestos came in the early 1970s, and more general bans by authorities came in the 1980s and continue until today.<br><br>CONCLUSIONS: The rather late recognition of adverse effects of asbestos exposure in the general population and measures to decrease the exposure through more general bans came rather late. However, the very strong measures such as general bans in many countries have been a success. A Swedish study showed that the general ban and other measures have decreased the risk of malignancies due to occupational exposure. The effect of the bans on adverse effects in the general population has yet to be studied. Analysis of fibers in the lungs of persons born after the bans could be an efficient method.},
}
@article {pmid38318560,
year = {2024},
author = {Subahi, EA and Fadul, A and Mohamed, A and Alsayed, A and Ali, EA and Sayed, S and Mustafa, S and Wazwaz, B and Fadul, MH},
title = {Biphasic Peritoneal Mesothelioma Is a Rare Tumor and a Diagnostic Challenge: A Case Report.},
journal = {Cureus},
volume = {16},
number = {1},
pages = {e51725},
pmid = {38318560},
issn = {2168-8184},
abstract = {Malignant peritoneal mesothelioma (MPM) is a rare subtype of mesothelioma. There are three main histological subtypes of mesothelioma: epithelioid, sarcomatoid, and biphasic (mixed). Risk factors include asbestos exposure, previous radiation, and some germline mutations. Treatment includes surgical resection of amenable tumors or cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. We present a 34-year-old male who presented with weight loss, night sweats, and pleuritic chest pain and was found to have ascites with peritoneal nodularity on abdominal imaging. He had a history of tuberculosis contact, but no history of asbestos exposure. After a long challenging and interesting diagnostic process, he was subsequently diagnosed with biphasic MPM. The diagnostic challenge stems from not only the rarity of the tumor but also from the absence of risk factors, the unavailability of some special laboratory investigations, in addition to the potentially misleading effect of tuberculosis exposure history, a top differential diagnosis in the case. This is a case report of a really challenging and totally unexpected diagnosis of biphasic peritoneal mesothelioma in a patient with tuberculosis exposure, constitutional symptoms, but no history of asbestos exposure. It highlights the diagnostic process as well as the importance of early diagnosis to improve the overall survival of such malignancies.},
}
@article {pmid38301599,
year = {2024},
author = {Fitzgerald, SM},
title = {Resolving asbestos and ultrafine particulate definitions with carcinogenicity.},
journal = {Lung cancer (Amsterdam, Netherlands)},
volume = {189},
number = {},
pages = {107478},
doi = {10.1016/j.lungcan.2024.107478},
pmid = {38301599},
issn = {1872-8332},
mesh = {Humans ; *Lung Neoplasms ; *Asbestos ; Minerals ; *Calcinosis ; },
abstract = {As asbestos fibers and other fine particles have been studied extensively to correlate physical and chemical properties with their potential for negative human health impact on inhalation, there remains no concise definitions for the individual particle types nor collective considerations of combined variabilities. Extensive studies relating negative health to asbestos morphology, chemistry, surface effects, and biodurability form general qualitative bins of what is more likely causative or less, but do not provide enough information to quantitatively dismiss particles with parameters outside any given range. Further, natural mineral species and accessory mineralization makes standardization of universally applicable reference materials nearly unobtainable. With modern advent of engineered nanoparticles, we are adding even more unknowns to the universe of the microscopic size fraction and its potential for human disease, and our paradigm is challenged.},
}
@article {pmid38297314,
year = {2024},
author = {Reamon-Buettner, SM and Rittinghausen, S and Klauke, A and Hiemisch, A and Ziemann, C},
title = {Malignant peritoneal mesotheliomas of rats induced by multiwalled carbon nanotubes and amosite asbestos: transcriptome and epigenetic profiles.},
journal = {Particle and fibre toxicology},
volume = {21},
number = {1},
pages = {3},
pmid = {38297314},
issn = {1743-8977},
support = {BMBF-No. 03X0109A//BMBF-funded CarboTox "Development of screening methods to analyze the carcinogenic potentials of carbon nanotubes/ ; BMBF-No. 03X0109A//BMBF-funded CarboTox "Development of screening methods to analyze the carcinogenic potentials of carbon nanotubes/ ; BMBF-No. 03X0109A//BMBF-funded CarboTox "Development of screening methods to analyze the carcinogenic potentials of carbon nanotubes/ ; BMBF-No. 03X0109A//BMBF-funded CarboTox "Development of screening methods to analyze the carcinogenic potentials of carbon nanotubes/ ; BMBF-No. 03X0109A//BMBF-funded CarboTox "Development of screening methods to analyze the carcinogenic potentials of carbon nanotubes/ ; Nos. 507334 and 50781//Fraunhofer-ITEM-funded pilot research "MWCNT-Mesothelioma"/ ; Nos. 507334 and 50781//Fraunhofer-ITEM-funded pilot research "MWCNT-Mesothelioma"/ ; Nos. 507334 and 50781//Fraunhofer-ITEM-funded pilot research "MWCNT-Mesothelioma"/ ; Nos. 507334 and 50781//Fraunhofer-ITEM-funded pilot research "MWCNT-Mesothelioma"/ ; Nos. 507334 and 50781//Fraunhofer-ITEM-funded pilot research "MWCNT-Mesothelioma"/ ; },
mesh = {Humans ; Rats ; Animals ; *Mesothelioma, Malignant/complications/genetics ; Asbestos, Amosite/toxicity ; *Nanotubes, Carbon/toxicity ; *Mesothelioma/chemically induced/genetics ; Transcriptome ; Rats, Wistar ; *Asbestos/toxicity ; Carcinogenesis/chemically induced/genetics ; DNA Methylation ; Epigenesis, Genetic ; *Lung Neoplasms/chemically induced/genetics/pathology ; GADD45 Proteins ; Antigens, Differentiation/toxicity ; },
abstract = {BACKGROUND: Malignant mesothelioma is an aggressive cancer that often originates in the pleural and peritoneal mesothelium. Exposure to asbestos is a frequent cause. However, studies in rodents have shown that certain multiwalled carbon nanotubes (MWCNTs) can also induce malignant mesothelioma. The exact mechanisms are still unclear. To gain further insights into molecular pathways leading to carcinogenesis, we analyzed tumors in Wistar rats induced by intraperitoneal application of MWCNTs and amosite asbestos. Using transcriptomic and epigenetic approaches, we compared the tumors by inducer (MWCNTs or amosite asbestos) or by tumor type (sarcomatoid, epithelioid, or biphasic).<br><br>RESULTS: Genome-wide transcriptome datasets, whether grouped by inducer or tumor type, showed a high number of significant differentially expressed genes (DEGs) relative to control peritoneal tissues. Bioinformatic evaluations using Ingenuity Pathway Analysis (IPA) revealed that while the transcriptome datasets shared commonalities, they also showed differences in DEGs, regulated canonical pathways, and affected molecular functions. In all datasets, among highly- scoring predicted canonical pathways were Phagosome Formation, IL8 Signaling, Integrin Signaling, RAC Signaling, and TREM1 Signaling. Top-scoring activated molecular functions included cell movement, invasion of cells, migration of cells, cell transformation, and metastasis. Notably, we found many genes associated with malignant mesothelioma in humans, which showed similar expression changes in the rat tumor transcriptome datasets. Furthermore, RT-qPCR revealed downregulation of Hrasls, Nr4a1, Fgfr4, and Ret or upregulation of Rnd3 and Gadd45b in all or most of the 36 tumors analyzed. Bisulfite sequencing of Hrasls, Nr4a1, Fgfr4, and Ret revealed heterogeneity in DNA methylation of promoter regions. However, higher methylation percentages were observed in some tumors compared to control tissues. Lastly, global 5mC DNA, m6A RNA and 5mC RNA methylation levels were also higher in tumors than in control tissues.<br><br>CONCLUSIONS: Our findings may help better understand how exposure to MWCNTs can lead to carcinogenesis. This information is valuable for risk assessment and in the development of safe-by-design strategies.},
}
@article {pmid38292909,
year = {2024},
author = {Tagarakis, G and Tsolaki, F and Tagarakis, I},
title = {Commentary: The role of single nucleotide polymorphisms related to iron homeostasis in mesothelioma susceptibility after asbestos exposure: a genetic study on autoptic samples.},
journal = {Frontiers in public health},
volume = {12},
number = {},
pages = {1336545},
pmid = {38292909},
issn = {2296-2565},
mesh = {Humans ; Polymorphism, Single Nucleotide ; *Mesothelioma/genetics ; *Mesothelioma, Malignant ; *Asbestos/adverse effects ; Iron ; Homeostasis ; },
}
@article {pmid38292377,
year = {2023},
author = {Fazzo, L and Grande, E and Zona, A and Minelli, G and Crialesi, R and Iavarone, I and Grippo, F},
title = {Mortality rates from asbestos-related diseases in Italy during the first year of the COVID-19 pandemic.},
journal = {Frontiers in public health},
volume = {11},
number = {},
pages = {1243261},
pmid = {38292377},
issn = {2296-2565},
mesh = {Adult ; Humans ; Female ; Male ; Aged, 80 and over ; *Mesothelioma, Malignant ; *Asbestosis/epidemiology/etiology ; *Mesothelioma/epidemiology/etiology ; Pandemics ; *Lung Neoplasms ; *COVID-19/epidemiology/complications ; SARS-CoV-2 ; *Asbestos/adverse effects ; Italy/epidemiology ; },
abstract = {BACKGROUND AND AIM: Patients with interstitial lung diseases, including asbestosis, showed high susceptibility to the SARS-CoV-2 virus and a high risk of severe COVID-19 symptoms. Italy, highly impacted by asbestos-related diseases, in 2020 was among the European countries with the highest number of COVID-19 cases. The mortality related to malignant mesotheliomas and asbestosis in 2020 and its relationship with COVID-19 in Italy are investigated.<br><br>METHODS: All death certificates involving malignant mesotheliomas or asbestosis in 2010-2020 and those involving COVID-19 in 2020 were retrieved from the National Registry of Causes of Death. Annual mortality rates and rate ratios (RRs) of 2020 and 2010-2014 compared to 2015-2019 were calculated. The association between malignant pleural mesothelioma (MPM) and asbestosis with COVID-19 in deceased adults &#x2265;80 years old was evaluated through a logistic regression analysis (odds ratios: ORs), using MPM and asbestosis deaths COVID-19-free as the reference group. The hospitalization for asbestosis in 2010-2020, based on National Hospital Discharge Database, was analyzed.<br><br>RESULTS: In 2020, 746,343 people died; out of them, 1,348 involved MPM and 286 involved asbestosis. Compared to the period 2015-2019, the mortality involving the two diseases decreased in age groups below 80 years; meanwhile, an increasing trend was observed in subjects aged 80 years and older, with a relative mortality risks of 1.10 for MPM and 1.17 for asbestosis. In subjects aged &#x2265;80 years, deaths with COVID-19 were less likely to have MPM in both genders (men: OR = 0.22; women: OR = 0.44), while no departure was observed for asbestosis. A decrease in hospitalization in 2020 with respect to those in 2010-2019 in all age groups, both considering asbestosis as the primary or secondary diagnosis, was observed.<br><br>CONCLUSIONS: The increasing mortality involving asbestosis and, even if of slight entity, MPM, observed in people aged over 80 years during the 1[st] year of the COVID-19 pandemic, aligned in part with the previous temporal trend, could be due to several factors. Although no positive association with COVID-19 mortality was observed, the decrease in hospitalizations for asbestosis among individuals aged over 80 years, coupled with the increase in deaths, highlights the importance of enhancing home-based assistance during the pandemic periods for vulnerable patients with asbestos-related conditions.},
}
@article {pmid38250976,
year = {2023},
author = {Kang, MS and Chae, WR and Lee, YJ and Moon, KW},
title = {Occupational and Environmental Asbestos Exposure and Survival of Patients with Asbestos-Related Cancer: A Follow-Up Study on Patients with Malignant Mesothelioma and Asbestos-Related Lung Cancer in Korea.},
journal = {Toxics},
volume = {12},
number = {1},
pages = {},
pmid = {38250976},
issn = {2305-6304},
abstract = {Malignant mesothelioma and asbestos-related lung cancer are typically associated with a poor prognosis. However, it has been observed that some patients with these cancers survive significantly longer than the average survival period. While many preliminary studies have investigated factors influencing patient survival, the specific impact of asbestos exposure has not been thoroughly explored. We followed up with 546 patients with malignant mesothelioma and 902 patients with asbestos-related lung cancer, all identified as asbestos victims between 2009 and 2021. In both malignant mesothelioma and asbestos-related lung cancer, patients with occupational asbestos exposure exhibited not only shorter median survival times but also lower 3- and 5-year survival rates compared to those with environmental exposure. Additionally, a longer duration of occupational exposure and closer proximity to the source of asbestos were linked to shorter survival times and lower survival rates. Among the patients with occupational asbestos exposure, the highest hazard ratios (HRs) were observed in those who worked in the production of asbestos-containing products across both cancer types. In contrast, significant HRs were only noted in mesothelioma patients who lived near asbestos industries, slate houses, and redevelopment areas, within the environmentally exposed group.},
}
@article {pmid38249898,
year = {2023},
author = {Visonà, SD and Capella, S and Borrelli, P and Villani, S and Favaron, C and Kurzhunbaeva, Z and Colosio, C and Belluso, E},
title = {Asbestos burden in lungs of non-occupationally exposed women from Broni (Pavia, Italy): a postmortem SEM-EDS study.},
journal = {Journal of thoracic disease},
volume = {15},
number = {12},
pages = {6555-6569},
pmid = {38249898},
issn = {2072-1439},
abstract = {BACKGROUND: In Italy the incidence of malignant mesothelioma (MM) among women is remarkably high, due to the several contexts in which women had been exposed to asbestos. However, very few studies in literature focus on the inorganic lung content in women. The aim of this retrospective, observational study is to investigate the asbestos lung burden, in terms of concentration, dimensions and type of asbestos, in 42 women who died from MM and had been non-occupationally exposed to asbestos during the activity of the asbestos-cement plant located in Broni (Pavia, Northern Italy) where mainly chrysotile, crocidolite and amosite were used.<br><br>METHODS: Lung samples taken during forensic autopsies have been digested using sodium hypochlorite and filtered through a cellulose-ester membrane. The filter was examined using a scanning electron microscope and the chemical composition of the fibers was analyzed using an electron dispersive spectroscopy. The number of detected inorganic fibers, asbestos fibers and asbestos bodies (ABs) were normalized to 1 gram of dry tissue.<br><br>RESULTS: In six samples no asbestos has been detected. Overall, the most represented kind of asbestos was amosite, followed by crocidolite, tremolite/actinolite asbestos and chrysotile. The concentration of all inorganic fibers was significantly higher in women with environmental and household exposures compared with those with only environmental exposure (P=0.025), as well as the concentration of asbestos fibers (P=0.019) and ABs (P=0.049). We found a significant correlation between the concentration of asbestos fibers and the duration of exposure (rho =0.413, P=0.008), as well as with the latency of MM (rho =0.427, P=0.005). The distance of the residential address from the factory and the time spent daily in contact with asbestos did not influence the lung asbestos burden.<br><br>CONCLUSIONS: These results suggest the relevance of the lung clearance of asbestos, regarding mainly chrysotile. As a consequence, although scanning electron microscopy -energy dispersive X-ray spectroscopy (SEM-EDS) is considered the most reliable tool for assessing previous exposure to asbestos, its results should be interpreted with caution, especially in a legal context. In addition, our data confirm the relevance of environmental and household exposure in determining asbestos concentration in lungs and highlight the importance of household exposure.},
}
@article {pmid38247448,
year = {2024},
author = {Schüz, J and Kovalevskiy, E and Olsson, A and Moissonnier, M and Ostroumova, E and Ferro, G and Feletto, E and Schonfeld, SJ and Byrnes, G and Tskhomariia, I and Straif, K and Morozova, T and Kromhout, H and Bukhtiyarov, I},
title = {Cancer mortality in chrysotile miners and millers, Russian Federation: main results (Asbest Chrysotile Cohort-Study).},
journal = {Journal of the National Cancer Institute},
volume = {116},
number = {6},
pages = {866-875},
pmid = {38247448},
issn = {1460-2105},
support = {001/WHO_/World Health Organization/International ; /NH/NIH HHS/United States ; //Ministry of Health of the Russian Federation/ ; 2009-2014//National System of Chemical and Biological Safety of the Russian Federation/ ; //Federal State Budgetary Scientific Institution/ ; //Izmerov Research Institute of Occupational Health/ ; //International Agency for Research on Cancer/ ; 2015-2023/WHO_/World Health Organization/International ; /CA/NCI NIH HHS/United States ; /NH/NIH HHS/United States ; },
mesh = {Humans ; Male ; *Asbestos, Serpentine/adverse effects ; Female ; *Occupational Exposure/adverse effects ; *Lung Neoplasms/mortality/epidemiology ; Middle Aged ; Russia/epidemiology ; Cohort Studies ; *Occupational Diseases/mortality/epidemiology ; Adult ; Dust ; Aged ; Miners/statistics &amp; numerical data ; Mining/statistics &amp; numerical data ; },
abstract = {BACKGROUND: We investigated mortality in workers of the world's largest chrysotile mine and enrichment factories located in the town of Asbest, Russian Federation.<br><br>METHODS: This historical cohort study included all workers employed for at least 1&#x2009;year between 1975 and 2010 and follow-up until the end of 2015. Cumulative exposure to dust was estimated based on workers' complete occupational history linked to dust measurements systematically collected from the 1950s. Exposure to chrysotile fibers was estimated using dust-to-fiber conversion factors. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated as mortality rate ratios in Poisson regression models.<br><br>RESULTS: A total of 30&#x200a;445 (32% women) workers accumulated 721&#x200a;312 person-years at risk and 11&#x200a;110 (36%) died. Of the workers, 54% had more than 30&#x2009;years since their first exposure. We found an exposure-response between cumulative dust and lung cancer mortality in men. No clear association with dust exposure but a modest increase in the highest category of fiber exposure was seen for lung cancer in women. Mesothelioma mortality was increased (RR&#x2009;=&#x2009;7.64, 95% CI = 1.18 to 49.5, to at least 80 fibers per cm3 years and RR&#x2009;=&#x2009;4.56, 95% CI = 0.94 to 22.1, to at least 150&#x2009;mg/m3 years [dust]), based on 13 deaths. For colorectal and stomach cancer, there were inconsistent associations. No associations were seen for laryngeal or ovarian cancer.<br><br>CONCLUSION: In this large-scale epidemiological study in the world's largest active asbestos mine, we confirmed an increased risk of mesothelioma with high fiber exposure and an increasing mortality for lung cancer in men with increasing dust exposure. Less clear-cut increased lung cancer mortality was seen in the women. Continued mortality follow-up is warranted.},
}
@article {pmid38239857,
year = {2024},
author = {Behers, BM and Guske, CW and Behers, BJ and Kortum, SB and Bermingham, IG and Warner, CL and Carey, RI},
title = {Malignant Epithelioid Mesothelioma of the Tunica Vaginalis Testis Presenting as Hydrocele in a Kidney Transplant Recipient.},
journal = {Case reports in urology},
volume = {2024},
number = {},
pages = {9227764},
pmid = {38239857},
issn = {2090-696X},
abstract = {Mesotheliomas of the tunica vaginalis testis are rare malignant tumors that can present as a scrotal mass or hydrocele. These tumors are typically aggressive with high rates of recurrence and metastasis. Suspected risk factors for malignant mesothelioma include asbestos exposure, chronic inflammation, trauma, and persistent hydrocele. We report the case of a malignant epithelioid mesothelioma of the tunica vaginalis testis that presented as a finding at hydrocelectomy and was ultimately treated with radical inguinal orchiectomy. This patient was on chronic immunosuppression therapy with tacrolimus and mycophenolate mofetil secondary to a kidney transplant but had none of the common risk factors for mesothelioma formation. To our knowledge, this is the first case describing a possible connection between chronic immunosuppression and mesothelioma of the tunica vaginalis. However, future studies are needed to investigate this association and discern whether this could have played a role in our patient or if his mesothelioma formation was coincidental.},
}
@article {pmid38201520,
year = {2023},
author = {Iser, S and Hintermair, S and Varga, A and Çelik, A and Sayan, M and Kankoç, A and Akyürek, N and Öğüt, B and Bertoglio, P and Capozzi, E and Solli, P and Ventura, L and Waller, D and Weber, M and Stubenberger, E and Ghanim, B},
title = {Validation of Inflammatory Prognostic Biomarkers in Pleural Mesothelioma.},
journal = {Cancers},
volume = {16},
number = {1},
pages = {},
pmid = {38201520},
issn = {2072-6694},
support = {ATU 67837709//Karl Landsteiner University of Health Sciences/ ; },
abstract = {Evoked from asbestos-induced inflammation, pleural mesothelioma represents a fatal diagnosis. Therapy ranges from nihilism to aggressive multimodality regimens. However, it is still unclear who ultimately benefits from which treatment. We aimed to re-challenge inflammatory-related biomarkers' prognostic value in times of modern immune-oncology and lung-sparing surgery. The biomarkers (leukocytes, hemoglobin, platelets, neutrophils, lymphocytes, monocytes, neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (PLR), C-reactive protein (CRP)) and clinical characteristics (age, sex, histology, therapy) of 98 PM patients were correlated to overall survival (OS). The median OS was 19.4 months. Significant OS advantages (Log-Rank) were observed in multimodal treatment vs. others (26.1 vs. 7.2 months, p < 0.001), surgery (pleurectomy/decortication) vs. no surgery (25.5 vs. 3.8 months, p < 0.001), a high hemoglobin level (cut-off 12 g/dL, 15 vs. 24.2 months, p = 0.021), a low platelet count (cut-off 280 G/L, 26.1 vs. 11.7 months, p < 0.001), and a low PLR (cut-off 194.5, 25.5 vs. 12.3 months, p = 0.023). Histology (epithelioid vs. non-epithelioid, p = 0.002), surgery (p = 0.004), CRP (cut-off 1 mg/dL, p = 0.039), and platelets (p = 0.025) were identified as independent prognostic variables for this cohort in multivariate analysis (Cox regression, covariates: age, sex, histology, stage, CRP, platelets). Our data verified the previously shown prognostic role of systemic inflammatory parameters in patients treated with lung-sparing surgery within multimodality therapy.},
}
@article {pmid38192052,
year = {2024},
author = {Carney, JM and Sporn, TA and Roggli, VL and Pavlisko, EN},
title = {The diagnosis of asbestosis in the 21[st] century: a clinicopathological correlation of 102 cases.},
journal = {Ultrastructural pathology},
volume = {48},
number = {2},
pages = {137-148},
doi = {10.1080/01913123.2023.2299874},
pmid = {38192052},
issn = {1521-0758},
mesh = {Male ; Humans ; Female ; Middle Aged ; Aged ; Aged, 80 and over ; *Asbestosis/pathology ; *Asbestos ; Lung/pathology ; *Mesothelioma/complications/pathology ; Asbestos, Amosite ; *Lung Neoplasms/pathology ; *Mesothelioma, Malignant ; *Occupational Exposure ; },
abstract = {Asbestosis, defined as diffuse pulmonary fibrosis caused by inhalation of asbestos fibers, occurs after heavy exposures to asbestos dust over several decades. Because workplace exposures have been significantly curtailed since the banning of asbestos in insulation products, we were interested in examining the clinicopathological characteristics of cases diagnosed in the 21[st] century. The consultation files of one of the authors (VLR) were reviewed for cases of asbestosis diagnosed since 1/1/2001. 102 cases were identified, with a median age of 75 years (range: 45-89). There were 100 men and 2 women. The women were from Turkey and Brazil (none from the United States). Malignancies were present in 78 cases, including 38 lung cancers, 29 pleural mesotheliomas, and 8 peritoneal mesotheliomas. The grade of asbestosis was available in 88 cases (median severity of 2; scale: 1-4). Pleural plaque was present in 94% of cases. The most common exposure categories were insulators (39), shipyard workers (16), asbestos manufacturing (9), boiler workers (8) and pipefitter/welders (6). The median duration of exposure was 33 years (range: 2-49 years). Lung fiber burden analysis was performed in 34 cases, with amosite being the predominant fiber type. Results were compared with similar information for 475 cases diagnosed prior to 1/1/2001.},
}
@article {pmid38190277,
year = {2024},
author = {Hung, YP and Chirieac, LR},
title = {Molecular and Immunohistochemical Testing in Mesothelioma and Other Mesothelial Lesions.},
journal = {Archives of pathology &amp; laboratory medicine},
volume = {148},
number = {5},
pages = {e77-e89},
doi = {10.5858/arpa.2023-0213-RA},
pmid = {38190277},
issn = {1543-2165},
mesh = {Humans ; *Mesothelioma/diagnosis/genetics/metabolism/pathology ; *Immunohistochemistry ; *Biomarkers, Tumor/genetics/metabolism/analysis ; Neoplasms, Mesothelial/diagnosis/genetics/metabolism/pathology ; Mesothelioma, Malignant/diagnosis/genetics/pathology/metabolism ; Mutation ; *Tumor Suppressor Proteins ; *Ubiquitin Thiolesterase ; },
abstract = {CONTEXT.&#x2014;: Molecular testing has increasingly been utilized in the evaluation of mesothelioma. Diffuse mesothelioma comprises multiple distinct genetic subgroups. While most diffuse mesotheliomas lack oncogenic kinase mutations and instead harbor alterations involving tumor suppressors and chromatin regulators, a minor subset of tumors is characterized by uncommon alterations such as germline mutations, genomic near-haploidization, ALK rearrangement, ATF1 rearrangement, or EWSR1::YY1 fusion.<br><br>OBJECTIVE.&#x2014;: To provide updates on the salient molecular features of diffuse mesothelioma, mesothelioma in situ, and other mesothelial lesions: well-differentiated papillary mesothelial tumor, adenomatoid tumor, peritoneal inclusion cyst, and others. We consider the diagnostic, prognostic, and predictive utility of molecular testing in mesothelial lesions.<br><br>DATA SOURCES.&#x2014;: We performed a literature review of recently described genetic features, molecular approaches, and immunohistochemical tools, including BAP1, MTAP, and merlin in mesothelioma and other mesothelial lesions.<br><br>CONCLUSIONS.&#x2014;: Our evolving understanding of the molecular diversity of diffuse mesothelioma and other mesothelial lesions has led to considerable changes in pathology diagnostic practice, including the application of immunohistochemical markers such as BAP1, MTAP, and merlin (NF2), which are surrogates of mutation status. In young patients and/or those without significant asbestos exposure, unusual mesothelioma genetics such as germline mutations, ALK rearrangement, and ATF1 rearrangement should be considered.},
}
@article {pmid38182448,
year = {2024},
author = {Carney, JM and Roggli, VL and Glass, CH and Piña-Oviedo, S and Pavlisko, EN},
title = {The over diagnosis of diffuse mesothelioma: An analysis of 311 cases with recommendations for the avoidance of pitfalls.},
journal = {Annals of diagnostic pathology},
volume = {68},
number = {},
pages = {152248},
doi = {10.1016/j.anndiagpath.2023.152248},
pmid = {38182448},
issn = {1532-8198},
mesh = {Humans ; Overdiagnosis ; *Pleural Neoplasms/diagnosis/metabolism/pathology ; Biomarkers, Tumor/analysis ; *Mesothelioma/diagnosis/pathology ; *Mesothelioma, Malignant/diagnosis ; *Carcinoma/pathology ; *Lung Neoplasms/diagnosis/pathology ; Diagnosis, Differential ; },
abstract = {BACKGROUND: The diagnosis of mesothelioma may be challenging. We investigated a large database of cases in order to determine the frequency with which a diagnosis of mesothelioma was made incorrectly and the most frequent causes of error.<br><br>DESIGN: A database including more than 4000 consultation cases of histologically confirmed mesothelioma was examined to identify cases in which mesothelioma was diagnosed by at least one pathologist when the available information pointed towards a different diagnosis.<br><br>RESULTS: There were 311 cases misdiagnosed as mesothelioma. The most common category was metastatic carcinoma to the pleura or peritoneum (129 cases: 73 lung carcinomas, 15 renal cell carcinomas). The next most common category was primary lung cancer (111 cases: 55 sarcomatoid carcinoma, 56 pseudomesotheliomatous carcinoma). The third most common category was primary malignancies arising from or near the serosal membranes (33 cases). The fourth most common category was fibrous pleurisy (38 cases). The most common errors were failure to consider important radiographic information regarding the gross distribution of tumor, lack of awareness or consideration of another malignancy, overreliance on certain immunohistochemical results, and failure to perform certain diagnostic histochemical, immunohistochemical, or ultrastructural studies.<br><br>CONCLUSIONS: There are a number of diagnostic pitfalls that can lead to the over diagnosis of mesothelioma. Careful attention to clinical and radiographic information as well as performance of appropriate ancillary tests can help to prevent such misdiagnoses. Detailed examples will be presented to assist in the avoidance of these pitfalls with emphasis on the most commonly observed errors.},
}
@article {pmid38176439,
year = {2024},
author = {van der Linde, LIS and Hantzsch-Kuhn, B and Ellebrecht, D and Stellmacher, F and Welker, L},
title = {[Interdisciplinary diagnostics and therapy of malignant mesothelioma].},
journal = {Pneumologie (Stuttgart, Germany)},
volume = {78},
number = {4},
pages = {262-268},
doi = {10.1055/a-2202-5445},
pmid = {38176439},
issn = {1438-8790},
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/therapy/drug therapy ; *Pleural Neoplasms/diagnosis/therapy/pathology ; Prognosis ; Combined Modality Therapy ; },
abstract = {The asbestos-related malignant mesothelioma (MM) is one of the common occupational cancers in Germany with approximately 1000 new cases per year. Provided that the appropriate diagnostic criteria are fulfilled, MM can be diagnosed with high specificity from both histological and cytological specimens. However, many MM are detected cyto-/histologically only at advanced stages. Clinical/radiological aspects complement each other and enable interdisciplinary assessment of tumor stage and individualized decisions on the best possible therapeutic options. Diagnostically, video-assisted thoracoscopy (VATS) has the highest priority. Therapy planning is based on the MM subtype, tumor spread and stage, and the patient's clinical condition. MM has generally a very unfavorable prognosis. Accordingly, the standard therapy aims at a macroscopic radical tumor resection in terms of cytoreduction within the framework of a suitable multimodal therapy concept (chemotherapy, radiotherapy, psychooncology). The aim of palliative measures should be primarily symptom control. Overall, interdisciplinary diagnosis and therapy of MM is crucial for the best possible care of MM patients.},
}
@article {pmid38166430,
year = {2024},
author = {Shaker, N and Blankenship, H and Shaker, N and Ben Musa, R and Niu, S and Alrohaibani, A and Mansoor, I and Abu Shakra, R and Sangueza, OP},
title = {Malignant Para-Testicular Mesothelioma: A Rare Presentation in the Tunica Vaginalis of an Elderly Male With No Prior Asbestos Exposure.},
journal = {International journal of surgical pathology},
volume = {32},
number = {6},
pages = {1117-1122},
doi = {10.1177/10668969231215426},
pmid = {38166430},
issn = {1940-2465},
mesh = {Humans ; Male ; Aged ; *Testicular Neoplasms/pathology/diagnosis ; *Mesothelioma, Malignant/pathology/diagnosis ; *Biomarkers, Tumor/analysis/metabolism ; Diagnosis, Differential ; Mesothelioma/diagnosis/pathology ; Testis/pathology ; Lung Neoplasms/diagnosis/pathology ; },
abstract = {Malignant mesothelioma of the tunica vaginalis is an extremely rare and aggressive tumor that is frequently encountered in elderly patients. The diagnosis of malignant mesothelioma of the tunica vaginalis poses a diagnostic challenge due to its infrequency and nonspecific clinical presentation. Histopathological examination and immunohistochemical staining are essential in differentiating this tumor from other para-testicular masses and establishing a definitive diagnosis. Early detection and comprehensive treatment planning are crucial for improving the prognosis and overall outcomes for patients with this rare malignancy. We present a report of malignant mesothelioma of the tunica vaginalis in a 78-year-old male patient with no history of asbestos exposure who presented with a large infiltrative left para-testicular mass. Histopathological examination revealed a biphasic proliferation composed of epithelioid and spindle cells with infiltrative features, foci of necrosis, and increased mitotic figures. Immunohistochemical staining exhibited positive staining for WT1, D2-40, and calretinin, supporting the mesothelial origin of the tumor. Notably, BerEP4 staining was negative, arguing against carcinoma. Immunostaining for keratin 5 was positive, supporting the mesothelial differentiation. The Ki67 proliferation index was high. The differential diagnosis included adenomatoid tumors, germ cell tumors, and pleomorphic sarcoma. We aim to discuss the clinical presentation, diagnostic approach, and therapeutic approaches of this rare entity.},
}
@article {pmid38153786,
year = {2024},
author = {Brims, F and Kumarasamy, C and Menon, L and Olsen, N and de Klerk, N and Franklin, P},
title = {The Western Australian Mesothelioma Registry: Analysis of 60 years of cases.},
journal = {Respirology (Carlton, Vic.)},
volume = {29},
number = {4},
pages = {288-294},
doi = {10.1111/resp.14648},
pmid = {38153786},
issn = {1440-1843},
support = {1197652//National Health and Medical Research Council/ ; //Western Australia Department of Health/ ; },
mesh = {Male ; Female ; Humans ; Western Australia/epidemiology ; Australia/epidemiology ; *Mesothelioma/epidemiology ; *Mesothelioma, Malignant ; *Asbestos/adverse effects ; *Pleural Neoplasms/etiology/complications ; Registries ; Incidence ; },
abstract = {BACKGROUND AND OBJECTIVE: Australia introduced a partial ban on asbestos consumption in 1984. There is continuing concern about exposure to asbestos in the built environment and non-occupational exposures. The aim of this study was to describe epidemiological trends of mesothelioma in Western Australia (WA) over the 60 years since the first case was recorded.<br><br>METHODS: Every case of mesothelioma notified to the WA Cancer Registry is reviewed by an expert panel. Data include demographic and clinical variables including principal mode of asbestos exposure and age at first exposure. Trends over time for survival, latency and pathological subtype of mesothelioma where analysed. Incidence rates for cases exposed during home renovation where calculated.<br><br>RESULTS: Two thousand seven hundred ninety-six cases of mesothelioma were identified with males comprising the majority (n&#x2009;=&#x2009;2368, 84.7%). The median (IQR) age at diagnosis was 70 (62-78) years, and median latency of 47 (38-55) years. Pleural mesothelioma was recorded in 2620 (93.7%) cases with the epithelioid subtype most prevalent (n&#x2009;=&#x2009;1730, 61.9%). Overall, median survival was 298 (128-585) days and latency 46 (37-54) years, both effectively doubling over the study period. Non-occupational exposures were proportionally higher in females (52.6%), compared with males (9.5%). Home renovation was the primary exposure in 227 (8.1%) cases, with number of cases and incidence rate ratio peaking in 2005/09 but subsequently decreasing.<br><br>CONCLUSION: The annual number of cases of mesothelioma in WA may have hit a plateau. The majority of females have non-occupational exposures and incidence rates from home renovation exposure may have peaked, suggesting the ban on asbestos has been effective.},
}
@article {pmid38136442,
year = {2023},
author = {Weber, DG and Casjens, S and Wichert, K and Lehnert, M and Taeger, D and Rihs, HP and Brüning, T and Johnen, G and The MoMar Study Group, },
title = {Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies.},
journal = {Cancers},
volume = {15},
number = {24},
pages = {},
pmid = {38136442},
issn = {2072-6694},
abstract = {Mesothelioma is an aggressive cancer, strongly associated with prior exposure to asbestos. Commonly, tumors are detected at late stages of the disease. Detection at early stages might be meaningful, because therapies might be more effective when the tumor burden is relatively low and the tumor has not spread to distant sites. Circulating biomarkers in blood might be a promising tool to improve the early detection of mesothelioma, but for screening in asymptomatic subjects, candidate biomarkers need to be validated in appropriate studies. This study was conducted to assess the performance of biomarkers in liquid biopsies to detect mesothelioma at early stages. Over a period of 10 years, 2769 volunteers formerly exposed to asbestos were annually examined and liquid biopsies were collected. A follow-up was completed 17 months after the last blood collection. The article provides a detailed overview of our lessons learned and experiences of conducting a prospective, longitudinal, multicenter study. The existing cohort of individuals at risk is highly suitable for the validation of blood-based biomarkers for the early detection of mesothelioma as well as lung cancer.},
}
@article {pmid38136353,
year = {2023},
author = {Bertin, B and Zugman, M and Schvartsman, G},
title = {The Current Treatment Landscape of Malignant Pleural Mesothelioma and Future Directions.},
journal = {Cancers},
volume = {15},
number = {24},
pages = {},
pmid = {38136353},
issn = {2072-6694},
abstract = {The incidence of malignant pleural mesothelioma is expected to increase globally. New treatment options for this malignancy are eagerly awaited to improve the survival and quality of life of patients. The present article highlights the results of recent advances in this field, analyzing data from several relevant trials. The heterogeneous tumor microenvironment and biology, together with the low mutational burden, pose a challenge for treating such tumors. So far, no single biomarker has been soundly correlated with targeted therapy development; thus, combination strategies are often required to improve outcomes. Locally applied vaccines, the expansion of genetically engineered immune cell populations such as T cells, the blockage of immune checkpoints that inhibit anti-tumorigenic responses and chemoimmunotherapy are among the most promising options expected to change the mesothelioma treatment landscape.},
}
@article {pmid38136333,
year = {2023},
author = {Cedres, S and Valdivia, A and Iranzo, P and Callejo, A and Pardo, N and Navarro, A and Martinez-Marti, A and Assaf-Pastrana, JD and Felip, E and Garrido, P},
title = {Current State-of-the-Art Therapy for Malignant Pleural Mesothelioma and Future Options Centered on Immunotherapy.},
journal = {Cancers},
volume = {15},
number = {24},
pages = {},
pmid = {38136333},
issn = {2072-6694},
abstract = {Malignant pleural mesothelioma (MPM) is a locally aggressive disease related to asbestos exposure with a median survival for untreated patients of 4-8 months. The combination of chemotherapy based on platinum and antifolate is the standard treatment, and the addition of bevacizumab adds two months to median survival. Recently, in first-line treatment, immunotherapy combining nivolumab with ipilimumab has been shown to be superior to chemotherapy in the CheckMate-743 study in terms of overall survival (18.1 months), leading to its approval by the FDA and EMA. The positive results of this study represent a new standard of treatment for patients with MPM; however, not all patients will benefit from immunotherapy treatment. In an effort to improve the selection of patient candidates for immunotherapy for different tumors, biomarkers that have been associated with a greater possibility of response to treatment have been described. MPM is a type of tumor with low mutational load and neo-antigens, making it a relatively non-immunogenic tumor for T cells and possibly less susceptible to responding to immunotherapy. Different retrospective studies have shown that PD-L1 expression occurs in 20-40% of patients and is associated with a poor prognosis; however, the predictive value of PD-L1 in response to immunotherapy has not been confirmed. The purpose of this work is to review the state of the art of MPM treatment in the year 2023, focusing on the efficacy results of first-line or subsequent immunotherapy studies on patients with MPM and possible chemo-immunotherapy combination strategies. Additionally, potential biomarkers of response to immunotherapy will be reviewed, such as histology, PD-L1, lymphocyte populations, and TMB.},
}
@article {pmid38136262,
year = {2023},
author = {Cerbone, L and Orecchia, S and Bertino, P and Delfanti, S and de Angelis, AM and Grosso, F},
title = {Clinical Next Generation Sequencing Application in Mesothelioma: Finding a Golden Needle in the Haystack.},
journal = {Cancers},
volume = {15},
number = {24},
pages = {},
pmid = {38136262},
issn = {2072-6694},
abstract = {Mesothelioma comprises a group of rare cancers arising from the mesothelium of the pleura, peritoneum, tunica vaginalis testis and pericardium. Mesothelioma is generally associated with asbestos exposure and has a dismal prognosis, with few therapeutic options. Several next generation sequencing (NGS) experiments have been performed on mesothelioma arising at different sites. These studies highlight a genomic landscape mainly characterized by a high prevalence (>20%) of genomic aberrations leading to functional losses in oncosuppressor genes such as BAP1, CDKN2A, NF2, SETD2 and TP53. Nevertheless, to date, evidence of the effect of targeting these alterations with specific drugs is lacking. Conversely, 1-2% of mesothelioma might harbor activating mutations in oncogenes with specifically approved drugs. The goal of this review is to summarize NGS applications in mesothelioma and to provide insights into target therapy of mesothelioma guided by NGS.},
}
@article {pmid38134842,
year = {2024},
author = {Ledda, C and Loreto, C and Lombardo, C and Cardile, V and Rapisarda, V},
title = {Mesothelin methylation, soluble mesothelin related protein levels and inflammation profiling in workers chronically exposed to naturally occurring asbestos fibers.},
journal = {Translational oncology},
volume = {40},
number = {},
pages = {101872},
pmid = {38134842},
issn = {1936-5233},
abstract = {Exposure to asbestiform fibers, including chrysotile and amphibole, is carcinogenic, causing malignant pleural mesothelioma (MPM) when inhaled. Some populations globally face Naturally Occurring Asbestos (NOA) exposure, leading to MPM cases like in Biancavilla, Italy, from Fluoro-edenite (FE) contamination. Studies show NOA exposure causes epigenetic changes, focusing on mesothelin methylation, an MPM marker, and altered inflammation, emphasizing the health risks of FE and asbestos. This research, conducted from February 2022 to October 2022, studied 125 construction workers from Biancavilla and 125 controls from 40 km away without Biancavilla work history. With at least ten years in construction and no respiratory conditions, participants underwent medical assessments and gave blood samples for analysis, including inflammation markers, mesothelin methylation, and soluble mesothelin-related protein levels. The results showed similar demographics but differing inflammation and methylation levels in exposed workers, suggesting long-term cellular changes. Pearson correlation showed intricate biomarker relationships. Significant inflammatory differences were found between FE exposed and non-exposed workers, indicating potential health impacts from FE. This raises concerns for communities like Biancavilla, emphasizing the importance of extensive epigenetic research for public health.},
}
@article {pmid38126124,
year = {2023},
author = {Beckett, EM and Abelmann, A and Roberts, B and Lewis, RC and Cheatham, D and Miller, EW and Hall, E and Pierce, JS},
title = {An updated evaluation of reported no-observed adverse effect levels for chrysotile, amosite, and crocidolite asbestos for lung cancer and mesothelioma.},
journal = {Critical reviews in toxicology},
volume = {53},
number = {10},
pages = {611-657},
doi = {10.1080/10408444.2023.2283169},
pmid = {38126124},
issn = {1547-6898},
mesh = {Humans ; Asbestos, Crocidolite/toxicity/analysis ; Asbestos, Serpentine/toxicity ; Asbestos, Amosite/analysis ; *Lung Neoplasms/chemically induced/epidemiology ; No-Observed-Adverse-Effect Level ; *Mesothelioma/chemically induced/epidemiology ; *Mesothelioma, Malignant/chemically induced/complications ; Asbestos, Amphibole/toxicity/analysis ; *Asbestos/toxicity/analysis ; },
abstract = {This analysis updates two previous analyses that evaluated the exposure-response relationships for lung cancer and mesothelioma in chrysotile-exposed cohorts. We reviewed recently published studies, as well as updated information from previous studies. Based on the 16 studies considered for chrysotile (<10% amphibole), we identified the "no-observed adverse effect level" (NOAEL) for lung cancer and/or mesothelioma; it should be noted that smoking or previous or concurrent occupational exposure to amphiboles (if it existed) was not controlled for. NOAEL values ranged from 2.3-<11.5 f/cc-years to 1600-3200 f/cc-years for lung cancer and from 100-<400 f/cc-years to 800-1599 f/cc-years for mesothelioma. The range of best-estimate NOAELs was estimated to be 97-175 f/cc-years for lung cancer and 250-379 f/cc-years for mesothelioma. None of the six cohorts of cement or friction product manufacturing workers exhibited an increased risk at any exposure level, while all but one of the six studies of textile workers reported an increased risk at one or more exposure levels. This is likely because friction and cement workers were exposed to much shorter chrysotile fibers. Only eight cases of peritoneal mesothelioma were reported in all studies on predominantly chrysotile-exposed cohorts combined. This analysis also proposed best-estimate amosite and crocidolite NOAELs for mesothelioma derived by the application of relative potency estimates to the best-estimate chrysotile NOAELs for mesothelioma and validated by epidemiology studies with exposure-response information. The best-estimate amosite and crocidolite NOAELs for mesothelioma were 2-5 f/cc-years and 0.6-1 f/cc-years, respectively. The rate of peritoneal mesothelioma in amosite- and crocidolite-exposed cohorts was between approximately 70- to 100-fold and several-hundred-fold higher than in chrysotile-exposed cohorts, respectively. These findings will help characterize potential worker and consumer health risks associated with historical and current chrysotile, amosite, and crocidolite exposures.},
}
@article {pmid38090310,
year = {2023},
author = {Liu, B and Niu, L and Lee, FF},
title = {Utilizing residential histories to assess environmental exposure and socioeconomic status over the life course among mesothelioma patients.},
journal = {Journal of thoracic disease},
volume = {15},
number = {11},
pages = {6126-6139},
pmid = {38090310},
issn = {2072-1439},
support = {R21 CA235153/CA/NCI NIH HHS/United States ; },
abstract = {BACKGROUND: Exposure misclassification based solely on the address at cancer diagnosis has been widely recognized though not commonly assessed.<br><br>METHODS: We linked 1,015 mesothelioma cases diagnosed during 2011-2015 from the New York State Cancer Registry to inpatient claims and LexisNexis administrative data and constructed residential histories. Percentile ranking of exposure to ambient air toxics and socioeconomic status (SES) were based on the National Air Toxic Assessment and United States Census data, respectively. To facilitate comparisons over time, relative exposures (REs) were calculated by dividing the percentile ranking at individual census tract by the state-level average and subtracting one. We used generalized linear regression models to compare the RE in the past with that at cancer diagnosis, adjusting for patient-level characteristics.<br><br>RESULTS: Approximately 43.7% of patients had residential information available for up to 30 years, and 96.0% up to 5 years. The median number of unique places lived was 4 [interquartile range (IQR), 2-6]. The time-weighted-average RE from all addresses available had a median of -0.11 (IQR, -0.50 to 0.30) for air toxics and -0.28 (IQR, -0.65 to 0.25) for SES. RE associated with air toxics (but not SES) was significantly higher for earlier addresses than addresses at cancer diagnosis for the 5-year [annual increase =1.24%; 95% confidence interval (CI): 0.71-1.77%; n=974] and 30-year (annual increase =0.36%; 95% CI: 0.25-0.48%; n=444) look-back windows, respectively.<br><br>CONCLUSIONS: Environmental exposure to non-asbestos air toxics among mesothelioma patients may be underestimated if based solely on the address at diagnosis. With geospatial data becoming more readily available, incorporating cancer patients' residential history would lead to reduced exposure misclassification and accurate health risk estimates.},
}
@article {pmid38089107,
year = {2023},
author = {Tibaduiza Torres, AL and Betancur Romero, JE and Silva Aparicio, A and Rico Mendoza, MA},
title = {[Malignant mesothelioma in Colombia: burden of disease, overview, and subnational sociodemographic index, 2015-2020Mesotelioma maligno na Colômbia: carga de morbidade, visão geral e índice sociodemográfico subnacional, entre 2015 e 2020].},
journal = {Revista panamericana de salud publica = Pan American journal of public health},
volume = {47},
number = {},
pages = {e95},
pmid = {38089107},
issn = {1680-5348},
abstract = {OBJECTIVE: Establish the disease burden of malignant mesothelioma (MM) in Colombia between 2015 and 2020, and its association with the subnational sociodemographic development index (SDI) and with asbestos sites.<br><br>METHODS: Mixed ecological study of the Colombian population diagnosed with MM (according to ICD-10) from 2015 to 2020. The global burden of disease (GBD) was estimated using the methodology proposed by Murray and Lopez, based on prevalence and mortality data obtained from official sources. The subnational (departmental level) SDI was estimated as a measure of socioeconomic development. Linear regressions were established with the GBD, SDI, and documented asbestos sites.<br><br>RESULTS: The estimated GBD of MM in Colombia during 2015-2020 was 51.71 disability-adjusted life years (DALYs) per 1 000 000 inhabitants (15 375.79 total DALYs), with predominance in people over 50 years of age (91.1%) and males (66.4%).Bogot&#xe1; and Valle del Cauca were the departments with the highest number of adjusted DALYs. Bogot&#xe1; had the highest SDI and Guain&#xed;a and Cesar had the lowest. There was evidence of an association between DALYs and SDI, explaining 22.8% of DALYs.<br><br>CONCLUSION: Malignant mesothelioma is the cause of a large number of DALYs, predominantly in the departments with greater socioeconomic development and with companies that used to use asbestos. However, possible underdiagnosis of MM limits analysis of the information.},
}
@article {pmid38076518,
year = {2023},
author = {Shenouda, M and Gudmundsson, E and Li, F and Straus, CM and Kindler, HL and Dudek, AZ and Stinchcombe, T and Wang, X and Starkey, A and Armato, SG},
title = {Convolutional Neural Networks for Segmentation of Malignant Pleural Mesothelioma: Analysis of Probability Map Thresholds (CALGB 30901, Alliance).},
journal = {ArXiv},
volume = {},
number = {},
pages = {},
pmid = {38076518},
issn = {2331-8422},
support = {U10 CA180821/CA/NCI NIH HHS/United States ; U10 CA180882/CA/NCI NIH HHS/United States ; UG1 CA189863/CA/NCI NIH HHS/United States ; UG1 CA233253/CA/NCI NIH HHS/United States ; },
abstract = {Malignant pleural mesothelioma (MPM) is the most common form of malignant mesothelioma, with exposure to asbestos being the primary cause of the disease. To assess response to treatment, tumor measurements are acquired and evaluated based on a patient's longitudinal computed tomography (CT) scans. Tumor volume, however, is the more accurate metric for assessing tumor burden and response. Automated segmentation methods using deep learning can be employed to acquire volume, which otherwise is a tedious task performed manually. The deep learning-based tumor volume and contours can then be compared with a standard reference to assess the robustness of the automated segmentations. The purpose of this study was to evaluate the impact of probability map threshold on MPM tumor delineations generated using a convolutional neural network (CNN). Eighty-eight CT scans from 21 MPM patients were segmented by a VGG16/U-Net CNN. A radiologist modified the contours generated at a 0.5 probability threshold. Percent difference of tumor volume and overlap using the Dice Similarity Coefficient (DSC) were compared between the standard reference provided by the radiologist and CNN outputs for thresholds ranging from 0.001 to 0.9. CNN annotations consistently yielded smaller tumor volumes than radiologist contours. Reducing the probability threshold from 0.5 to 0.1 decreased the absolute percent volume difference, on average, from 43.96% to 24.18%. Median and mean DSC ranged from 0.58 to 0.60, with a peak at a threshold of 0.5; no distinct threshold was found for percent volume difference. The CNN exhibited deficiencies with specific disease presentations, such as severe pleural effusion or disease in the pleural fissure. No single output threshold in the CNN probability maps was optimal for both tumor volume and DSC. This study emphasized the importance of considering both figures of merit when evaluating deep learning-based tumor segmentations across probability thresholds. This work underscores the need to simultaneously assess tumor volume and spatial overlap when evaluating CNN performance. While automated segmentations may yield comparable tumor volumes to that of the reference standard, the spatial region delineated by the CNN at a specific threshold is equally important.},
}
@article {pmid38072464,
year = {2023},
author = {Turati, F and Rossi, M and Spinazzè, A and Pira, E and Cavallo, DM and Patel, L and Mensi, C and La Vecchia, C and Negri, E},
title = {Occupational asbestos exposure and ovarian cancer: updated systematic review.},
journal = {Occupational medicine (Oxford, England)},
volume = {73},
number = {9},
pages = {532-540},
doi = {10.1093/occmed/kqad122},
pmid = {38072464},
issn = {1471-8405},
support = {ARL_2/2018//'Fondazione Regionale per la Ricerca Biomedica'-'Bando Progetto Speciale 2017 su Patologie Amianto-Correlate'/ ; },
mesh = {Humans ; Female ; *Asbestos/adverse effects ; *Ovarian Neoplasms/etiology ; Risk ; *Occupational Exposure/adverse effects ; Time Factors ; *Mesothelioma/etiology ; *Occupational Diseases/diagnosis/etiology ; *Lung Neoplasms ; },
abstract = {BACKGROUND: The association between asbestos exposure and ovarian cancer has been questioned given the possible misdiagnosis of peritoneal mesothelioma as ovarian cancer.<br><br>AIMS: To update a systematic review on ovarian cancer risk in women occupationally exposed to asbestos, exploring the association with the time since first exposure and the duration of exposure.<br><br>METHODS: We searched PubMed from 2008 onwards, screened previous systematic reviews, combined standardized mortality ratios (SMR) using random effect models and quantified heterogeneity using the I2 statistic. To assess tumour misclassification, we compared the distribution of observed excess ovarian cancers (OEOC) to that expected (EEOC) from the distribution of peritoneal cancers in strata of latency and exposure duration.<br><br>RESULTS: Eighteen publications (20 populations), including a pooled analysis of 21 cohorts, were included. The pooled SMR was 1.79 (95% confidence interval 1.38-2.31), with moderate heterogeneity between studies (I2&#x2005;=&#x2005;42%), based on 144 ovarian cancer deaths/cases. The risk was increased for women with indirect indicators of higher exposure, longer duration and latency, and lower for chrysotile than for crocidolite exposure. The effect of duration and latency could not be completely disentangled, since no multivariate analysis was available for time-related variables. The dissimilarity index between OEOC and EEOC for the time since first exposure was small suggesting a similar pattern of risk.<br><br>CONCLUSIONS: While some misclassification between ovarian and peritoneal cancers cannot be excluded, the observed excess risk of ovarian cancer should be added to the overall disease burden of asbestos.},
}
@article {pmid38069464,
year = {2024},
author = {Visonà, SD and Bertoglio, B and Capella, S and Belluso, E and Austoni, B and Colosio, C and Kurzhunbaeva, Z and Ivic-Pavlicic, T and Taioli, E},
title = {Asbestos burden in lungs of mesothelioma patients with pleural plaques, lung fibrosis and/or ferruginous bodies at histology: a postmortem SEM-EDS study.},
journal = {Carcinogenesis},
volume = {45},
number = {3},
pages = {131-139},
doi = {10.1093/carcin/bgad090},
pmid = {38069464},
issn = {1460-2180},
mesh = {Humans ; *Pulmonary Fibrosis/complications/pathology ; *Mesothelioma, Malignant/complications/pathology ; *Asbestos/toxicity/analysis ; *Mesothelioma/chemically induced ; Lung/pathology ; *Lung Neoplasms/etiology/pathology ; *Occupational Exposure ; },
abstract = {The causal attribution of asbestos-related diseases to past asbestos exposures is of crucial importance in clinical and legal contexts. Often this evaluation is made based on the history of exposure, but this method presents important limitations. To assess past asbestos exposure, pleural plaques (PP), lung fibrosis and histological evidence of ferruginous bodies (FB) can be used in combination with anamnestic data. However, such markers have never been associated with a threshold value of inhaled asbestos. With this study we attempted to shed light on the dose-response relationship of PP, lung fibrosis and FBs, investigating if their prevalence in exposed individuals who died from malignant mesothelioma (MM) is related to the concentration of asbestos in lungs assessed using scanning electron microscopy equipped with energy dispersive spectroscopy. Moreover, we estimated the values of asbestos concentration in lungs associated with PP, lung fibrosis and FB. Lung fibrosis showed a significant positive relationship with asbestos lung content, whereas PP and FB did not. We identified, for the first time, critical lung concentrations of asbestos related to the presence of PP, lung fibrosis and FB at histology (respectively, 19 800, 26 400 and 27 400 fibers per gram of dry weight), that were all well-below the background levels of asbestos identified in our laboratory. Such data suggest that PP, lung fibrosis and FB at histology should be used with caution in the causal attribution of MM to past asbestos exposures, while evaluation of amphibole lung content using analytical electron microscopy should be preferred.},
}
@article {pmid38064629,
year = {2024},
author = {Yang, D and Zhou, Y and Lv, K},
title = {Analysis of Ki67 Protein Expression and Clinicopathological Features in Patients with Peritoneal Mesothelioma.},
journal = {Alternative therapies in health and medicine},
volume = {30},
number = {9},
pages = {202-209},
pmid = {38064629},
issn = {1078-6791},
mesh = {Humans ; *Ki-67 Antigen/metabolism ; *Peritoneal Neoplasms/metabolism/genetics ; *Mesothelioma/pathology/metabolism/mortality ; Male ; Female ; Prognosis ; Middle Aged ; *Biomarkers, Tumor/metabolism/genetics ; Aged ; Adult ; },
abstract = {BACKGROUND: At present, there are many treatments for peritoneal mesothelioma, but the treatment of peritoneal mesothelioma is still facing great challenges. Distant metastasis is the main cause of poor prognosis and death of patients with peritoneal mesothelioma. Ki67 is a cell proliferation marker. In recent years, it has been found to be used as a molecular marker for the diagnosis, treatment and prognosis of different tumor cells. Ki67 has been shown to play a crucial role in the occurrence and development of a variety of cancers. However, the clinical significance and biological function of Ki67 in peritoneal mesothelioma remain poorly understood.<br><br>PURPOSE: To clarify the expression of Ki67 in peritoneal mesothelioma (PC), and to explore the relationship between the expression level of Ki67 and the clinicopathological parameters and prognosis of patients with PC, and to explore the potential of Ki67 as a therapeutic target and prognostic biomarker for PC.<br><br>METHODS: TIMER database was used to compare the expression levels of Ki67 mRNA and protein in mesothelioma tissues and adjacent tissues. The relationship between the expression level of Ki67 in mesothelioma and clinicopathological characteristics, and the relationship between the expression level of Ki67 and the level of immune infiltration in mesothelioma were analyzed. The prognostic value of Ki67 in mesothelioma patients was predicted, and the overall survival curve was drawn according to the follow-up data. LinkedOmics database and GSEA were used to perform co-expression analysis and enrichment analysis of Ki67, respectively.<br><br>RESULTS: Bioinformatics analysis showed that Ki67 was highly expressed in peritoneal mesothelioma (P < .01). Immunohistochemistry showed that the positive rate of Ki67 in peritoneal mesothelioma was high, and the number of Ki67 positive cases was 62.0% (31/50 cases). Univariate analysis showed that TNM stage (P = .007), asbestos (P < .001), chemotherapy (P < .001), and Ki67 expression level (P = .029) were associated with prognosis. Multivariate analysis showed that Ki67 expression level (P = .039) and TNM stage (P = .029) were independent risk factors for the prognosis of peritoneal mesothelioma. Peritoneal mesothelioma patients with high Ki67 expression have poor OS. In addition, Ki67 is also associated with the immune infiltration of mesothelioma.<br><br>CONCLUSION: Ki67 is highly expressed in peritoneal mesothelioma. Ki67 protein plays an important role in the development of peritoneal mesothelioma and is one of the important factors to evaluate the prognosis of patients with peritoneal mesothelioma.},
}
@article {pmid38063957,
year = {2024},
author = {Martella, S and Aiello, MM and Bertaglia, V and Cau, R and Denaro, N and Cadoni, A and Novello, S and Scartozzi, M and Novello, G and Soto Parra, HJ and Saba, L and Solinas, C and Porcu, M},
title = {Malignant Pleural Mesothelioma: Staging and Radiological Response Criteria in Patients Treated with Immune Checkpoint Inhibitors.},
journal = {Targeted oncology},
volume = {19},
number = {1},
pages = {13-28},
pmid = {38063957},
issn = {1776-260X},
mesh = {Humans ; *Mesothelioma, Malignant/drug therapy ; Immune Checkpoint Inhibitors/therapeutic use ; Artificial Intelligence ; *Pleural Neoplasms/diagnostic imaging/drug therapy ; *Lung Neoplasms/diagnostic imaging/drug therapy ; Combined Modality Therapy ; },
abstract = {Malignant pleural mesothelioma (MPM) is a rare and challenging cancer associated with asbestos fiber exposure, which offers limited treatment options. Historically, platinum-based chemotherapy has been the primary approach, but recent developments have introduced immunotherapy as a promising alternative for the treatment of this disease. Nevertheless, the unique growth patterns and occasionally ambiguous progressive characteristics of MPM make the interpretation of radiological assessments complex. Immunotherapy further complicates matters by introducing unconventional treatment response patterns such as hyperprogression and pseudoprogression. Consequently, there is a growing imperative to integrate the standard RECIST criteria with the mesothelioma-specific mRECIST criteria (version 1.1), as outlined in iRECIST. This comprehensive review is driven by the intent to provide a valuable resource for radiologists and clinicians engaged in the diagnosis, treatment, and monitoring of MPM in the era of immunotherapy. Specifically, the current imaging methods employed for staging and follow-up will be exposed and discussed, with a focus on the technical specificities and the mRECIST 1.1 methodology. Furthermore, we will provide a discussion about major clinical trials related to the use of immunotherapy in MPM patients. Finally, the latest advancements in radiomics, the applications of artificial intelligence in MPM, and their potential impact on clinical practice for prognosis and therapy, are discussed.},
}
@article {pmid38054089,
year = {2023},
author = {Wang, D and Wang, YH and Chu, SC},
title = {Case Report: Early diagnosis and bevacizumab-based chemotherapy for primary pericardial mesothelioma: a case with occupational asbestos exposure history.},
journal = {Frontiers in cardiovascular medicine},
volume = {10},
number = {},
pages = {1257373},
pmid = {38054089},
issn = {2297-055X},
abstract = {BACKGROUND: Primary pericardial mesothelioma (PPM) is an exceedingly rare malignant cancer and has a poor prognosis, which has been partly attributed to its frequently delayed diagnosis due to its nonspecific syndromes, its similar presentation to benign pericardial diseases, and its non-definitive etiology. In many PPM cases, the time from presentation to definite diagnosis may last for several months or even over one year. Unlike pleural mesothelioma, the relationship between PPM and asbestos exposure remains unsettled. To date, there is no consensus on the treatment of PPM.<br><br>CASE REPORT: The patient is a 57-year-old male who had nonspecific syndromes and inconclusive image findings. The occupational long-term asbestos exposure history of this patient raised our concerns regarding potential malignancy when confronted with unexplained pericardial effusion accompanied by cardiac tamponade. The heightened suspicion prompted us to perform pericardiocentesis and biopsy on the third day after admission to our department. An early diagnosis of PPM was established by the pathological and immunohistochemical evaluation of the biopsy specimen two weeks after admission. Positron emission tomography-computed tomography revealed that the lesion was localized at the anterior part of the mediastinum without distant metastasis. This patient refused to receive cardiac surgery. He subsequently underwent six cycles of chemotherapy (cisplatin plus pemetrexed) in combination with bevacizumab (a humanized anti-VEGF antibody) as the first-line treatment, resulting in complete relief of symptoms and satisfactory outcomes with no complications. Four months after the first course, the patient initiated a second course of chemotherapy with a similar regimen, but he opted to discontinue the medical treatment after the initiation of the second course. The patient was transferred to the hospice care unit and unfortunately expired one year after the initial presentation.<br><br>CONCLUSION: We present a case of an early multidisciplinary clinical approach to diagnose and manage PPM with consideration of occupational asbestos exposure history and clinical symptoms. Bevacizumab-based chemotherapy remains an option for the treatment of PPM.},
}
@article {pmid38044849,
year = {2024},
author = {Klebe, S and Judge, M and Brcic, L and Dacic, S and Galateau-Salle, F and Nicholson, AG and Roggli, V and Nowak, AK and Cooper, WA},
title = {Mesothelioma in the pleura, pericardium and peritoneum: Recommendations from the International Collaboration on Cancer Reporting (ICCR).},
journal = {Histopathology},
volume = {84},
number = {4},
pages = {633-645},
doi = {10.1111/his.15106},
pmid = {38044849},
issn = {1365-2559},
mesh = {Humans ; Peritoneum ; Pleura ; Retrospective Studies ; *Mesothelioma/diagnosis ; *Mesothelioma, Malignant ; Pericardium ; *Pathology, Clinical/methods ; },
abstract = {AIMS: Mesothelioma is a rare malignancy of the serosal membranes that is commonly related to exposure to asbestos. Despite extensive research and clinical trials, prognosis to date remains poor. Consistent, comprehensive and reproducible pathology reporting form the basis of all future interventions for an individual patient, but also ensures that meaningful data are collected to identify predictive and prognostic markers.<br><br>METHODS AND RESULTS: This article details the International Collaboration on Cancer Reporting (ICCR) process and the development of the international consensus mesothelioma reporting data set. It describes the 'core' and 'non-core' elements to be included in pathology reports for mesothelioma of all sites, inclusive of clinical, macroscopic, microscopic and ancillary testing considerations. An international expert panel consisting of pathologists and a medical oncologist produced a set of data items for biopsy and resection specimens based on a critical review and discussion of current evidence, and in light of the changes in the 2021 WHO Classification of Tumours. The commentary focuses particularly upon new entities such as mesothelioma in situ and provides background on relevant and essential ancillary testing as well as implementation of the new requirement for tumour grading.<br><br>CONCLUSION: We recommend widespread and consistent implementation of this data set, which will facilitate accurate reporting and enhance the consistency of data collection, improve the comparison of epidemiological data, support retrospective research and ultimately help to improve clinical outcomes. To this end, all data sets are freely available worldwide on the ICCR website (www.iccr-cancer.org/data-sets).},
}
@article {pmid38041166,
year = {2023},
author = {Visonà, SD and Bertoglio, B and Favaron, C and Capella, S and Belluso, E and Colosio, C and Villani, S and Ivic-Pavlicic, T and Taioli, E},
title = {A postmortem case control study of asbestos burden in lungs of malignant mesothelioma cases.},
journal = {Journal of translational medicine},
volume = {21},
number = {1},
pages = {875},
pmid = {38041166},
issn = {1479-5876},
mesh = {Humans ; Female ; Male ; *Mesothelioma, Malignant/complications ; Asbestos, Serpentine ; Case-Control Studies ; *Mesothelioma/pathology ; *Lung Neoplasms/etiology/pathology ; *Asbestos ; Lung/pathology ; Tumor Microenvironment ; },
abstract = {BACKGROUND: Asbestos lung content is regarded as the most reliable tool for causal attribution of malignant mesothelioma (MM) to previous asbestos exposures. However, there is a lack of studies on asbestos burden in lungs of MM patients in comparison with healthy individuals. This study aims to provide such a comparison, investigating, as well, differences in asbestos lung burden with sex and time trends.<br><br>METHODS: Asbestos lung content has been assessed on formalin-fixed lung fragments using scanning electron microscopy coupled with energy dispersion spectroscopy (SEM-EDS) on individuals deceased from MM (cases) and healthy subjects without any lung disease who died from violent causes (controls) between 2005 and 2023.<br><br>RESULTS: Asbestos and asbestos bodies (ABs) were found, respectively, in 73.7% and 43.2% of cases and in 28 and 22% of controls; in MM cases the most represented asbestos types were crocidolite and amosite, whereas in controls it was tremolite-actinolite asbestos. The concentration of both asbestos fibers and ABs was statistically significantly higher in MM cases compared to controls. The mean asbestos fibers width was also significantly higher in cases than controls. Males and females with MM showed similar asbestos and ABs concentrations, but females had higher concentrations of chrysotile, and significantly lower fibers width compared to males. Time trends show that MM lung asbestos concentrations decreased starting in 2011.<br><br>DISCUSSION: The results suggest a correlation between asbestos burden in lungs and MM risk. The different concentration of chrysotile, as well as the different width of asbestos fibers in MM males and females might reflect a sex difference in response of the lung microenvironment to inhaled asbestos. Finally, this study provides the first pathological evidence of the effect of the ban of asbestos use, demonstrating a significant decrease of asbestos lung content after 2011.},
}
@article {pmid38038422,
year = {2023},
author = {Zupanc, C and Franko, A and Strbac, D and Kovac, V and Dolzan, V and Goricar, K},
title = {The association of genetic factors with serum calretinin levels in asbestos-related diseases.},
journal = {Radiology and oncology},
volume = {57},
number = {4},
pages = {473-486},
pmid = {38038422},
issn = {1581-3207},
mesh = {Humans ; *Asbestos/adverse effects ; *Asbestosis/genetics ; *Calbindin 2/blood ; *Mesothelioma, Malignant/genetics ; },
abstract = {BACKGROUND: Asbestos exposure is associated with different asbestos-related diseases, including malignant mesothelioma (MM). MM diagnosis is confirmed with immunohistochemical analysis of several markers, including calretinin. Increased circulating calretinin was also observed in MM. The aim of the study was to determine if CALB2 polymorphisms or polymorphisms in genes that can regulate calretinin expression are associated with serum calretinin levels or MM susceptibility.<br><br>SUBJECTS AND METHODS: The study included 288 MM patients and 616 occupationally asbestos-exposed subjects without MM (153 with asbestosis, 380 with pleural plaques and 83 without asbestos-related disease). Subjects were genotyped for seven polymorphisms in CALB2, E2F2, MIR335, NRF1 and SEPTIN7 genes using competitive allele-specific polymerase chain reaction (PCR). Serum calretinin was determined with ELISA in 545 subjects. Nonparametric tests, logistic regression and receiver operating characteristic (ROC) curve analysis were used for statistical analysis.<br><br>RESULTS: Carriers of at least one polymorphic CALB2 rs889704 allele had lower calretinin levels (P = 0.036). Carriers of two polymorphic MIR335 rs3807348 alleles had higher calretinin (P = 0.027), while carriers of at least one polymorphic NRF1 rs13241028 allele had lower calretinin levels (P = 0.034) in subjects without MM. Carriers of two polymorphic E2F2 rs2075995 alleles were less likely to develop MM (odds ratio [OR] = 0.64, 95% confidence interval [CI] = 0.43-0.96, P = 0.032), but the association was no longer significant after adjustment for age (P = 0.093). Optimal serum calretinin cut-off values differentiating MM patients from other subjects differed according to CALB2, NRF1, E2F2, and MIR335 genotypes.<br><br>CONCLUSIONS: The results of presented study suggest that genetic variability could influence serum calretinin levels. These findings could contribute to a better understanding of calretinin regulation and potentially to earlier MM diagnosis.},
}
@article {pmid38036250,
year = {2024},
author = {McNamee, N and Harvey, C and Gray, L and Khoo, T and Lingam, L and Zhang, B and Nindra, U and Yip, PY and Pal, A and Clay, T and Arulananda, S and Itchins, M and Pavlakis, N and Kao, S and Bowyer, S and Chin, V and Warburton, L and Pires da Silva, I and John, T and Solomon, B and Alexander, M and Nagrial, A},
title = {Brief Report: Real-World Toxicity and Survival of Combination Immunotherapy in Pleural Mesothelioma-RIOMeso.},
journal = {Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
volume = {19},
number = {4},
pages = {636-642},
doi = {10.1016/j.jtho.2023.11.014},
pmid = {38036250},
issn = {1556-1380},
mesh = {Humans ; Male ; Aged ; Female ; Nivolumab/adverse effects ; Ipilimumab/adverse effects ; Retrospective Studies ; *Lung Neoplasms/drug therapy/etiology ; Australia ; *Mesothelioma, Malignant ; *Mesothelioma/drug therapy/etiology ; *Pleural Neoplasms/drug therapy/etiology ; Immunotherapy/adverse effects ; *Asbestos ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; },
abstract = {BACKGROUND: Australia has one of the highest rates of asbestos-associated diseases. Mesothelioma remains an area of unmet need with a 5-year overall survival of 10%. First-line immunotherapy with ipilimumab and nivolumab is now a standard of care for unresectable pleural mesothelioma following the CheckMate 743 trial, with supportive data from the later line single-arm MAPS2 trial. RIOMeso evaluates survival and toxicity of this regimen in real-world practice.<br><br>METHODS: Demographic and clinicopathologic data of Australian patients treated with ipilimumab and nivolumab in first- and subsequent-line settings for pleural mesothelioma were collected retrospectively. Survival was reported using the Kaplan-Meier method and compared between subgroups with the log-rank test. Toxicity was investigator assessed using Common Terminology Criteria for Adverse Events version 5.0.<br><br>RESULTS: A total of 119 patients were identified from 11 centers. The median age was 72 years, 83% were male, 92% had Eastern Cooperative Oncology Group less than or equal to 1, 50% were past or current smokers, and 78% had known asbestos exposure. In addition, 50% were epithelioid, 19% sarcomatoid, 14% biphasic, and 17% unavailable. Ipilimumab and nivolumab were used first line in 75% of patients. Median overall survival (mOS) was 14.5 months (95% confidence interval [CI]: 13.0-not reached [NR]) for the entire cohort. For patients treated first line, mOS was 14.5 months (95% CI: 12.5-NR) and in second- or later-line patients was 15.4 months (95% CI: 11.2-NR). There was no statistically significant difference in mOS for epithelioid patients compared with nonepithelioid (19.1 mo [95% CI: 15.4-NR] versus 13.0 mo [95% CI: 9.7-NR], respectively, p&#xa0;= 0.064). Furthermore, 24% of the patients had a Common Terminology Criteria for Adverse Events grade greater than or equal to 3 adverse events, including three treatment-related deaths. Colitis was the most frequent adverse event.<br><br>CONCLUSIONS: Combination immunotherapy in real-world practice has poorer survival outcomes and seems more toxic compared with clinical trial data. This is the first detailed report of real-world survival and toxicity outcomes using ipilimumab and nivolumab treatment of pleural mesothelioma.},
}
@article {pmid38032359,
year = {2024},
author = {Geyer, SJ},
title = {A cluster of mesotheliomas reported in a case series does not implicate chrysotile asbestos-containing friction products as the cause of mesotheliomas.},
journal = {American journal of industrial medicine},
volume = {67},
number = {1},
pages = {81-82},
doi = {10.1002/ajim.23554},
pmid = {38032359},
issn = {1097-0274},
mesh = {Humans ; Asbestos, Serpentine/toxicity ; Friction ; *Mesothelioma/chemically induced/epidemiology ; *Asbestos/toxicity ; *Lung Neoplasms/etiology ; },
}
@article {pmid38030592,
year = {2024},
author = {Miller, A},
title = {Recognizing the pleura in asbestos-related pleuropulmonary disease: Known and new manifestations of pleural fibrosis.},
journal = {American journal of industrial medicine},
volume = {67},
number = {1},
pages = {73-80},
doi = {10.1002/ajim.23553},
pmid = {38030592},
issn = {1097-0274},
mesh = {Humans ; *Asbestos/toxicity ; Asbestos, Amphibole/toxicity ; *Asbestosis/diagnostic imaging/pathology ; Fibrosis ; Pain ; Pleura/diagnostic imaging/pathology ; *Pleural Diseases/diagnostic imaging/etiology ; *Pleurisy/pathology ; },
abstract = {Pleural thickening (PT) is a major consequence of exposure to all fiber types of asbestos. In recent decades, it is more prevalent than parenchymal asbestosis. Its manifestations occupy a full clinical and radiographic spectrum. Six major manifestations can be identified: (a) acute pleuritis generally with effusion; (b) diffuse PT or fibrous pleuritis; (c) rounded atelectasis; (d) circumscribed PT or plaques; (e) chronic pleuritic pain; and (f) mesothelioma. Review of the experience of workers and community members in Libby, MT to asbestiform fibers in vermiculite has confirmed the appearance of these previously known benign and malignant asbestos-related diseases as well as a unique pleuropulmonary disease characterized as lamellar PT and associated with progressive decline in pulmonary function and pleuritic pain. Despite previous literature asserting that PT represents a marker for asbestos exposure without significant effect on pulmonary function and physiology, the experience of Libby amphibole (LA) disease, along with other studies, indicates that PT plays a role in declining vital capacity in those with prolonged or unusual exposures such as those arising from LA.},
}
@article {pmid38017544,
year = {2023},
author = {Yoshida, M and Jimbo, N and Tsukamoto, R and Itoh, T and Kawahara, K and Mitsui, S and Tanaka, Y and Maniwa, Y},
title = {Sarcomatoid mesothelioma diagnosed in a patient with mesothelioma in situ: a case report on morphologic differences after 9-month interval with details analysis of cytology in early-stage mesothelioma.},
journal = {Diagnostic pathology},
volume = {18},
number = {1},
pages = {126},
pmid = {38017544},
issn = {1746-1596},
support = {23K08317//JSPS KAKENHI/ ; 23K08317//JSPS KAKENHI/ ; },
mesh = {Male ; Humans ; Aged ; In Situ Hybridization, Fluorescence ; Homozygote ; *Lung Neoplasms/diagnosis/genetics/pathology ; Sequence Deletion ; *Mesothelioma, Malignant ; *Mesothelioma/diagnosis/genetics/pathology ; *Pleural Neoplasms/diagnosis/genetics/pathology ; *Pleural Effusion/genetics ; *Sarcoma/genetics ; Biomarkers, Tumor/genetics/analysis ; Ubiquitin Thiolesterase/analysis/genetics ; },
abstract = {BACKGROUND: Overlapping morphological features of mesothelial cells have been rendered it difficult to distinguish between reactive and malignant conditions. The development of methods based on detecting genomic abnormalities using immunohistochemistry and fluorescence in situ hybridization have contributed markedly to solving this problem. It is important to identify bland mesothelioma cells on cytological screening, perform efficient genomic-based testing, and diagnose mesothelioma, because the first clinical manifestation of pleural mesothelioma is pleural effusion, which is the first sample available for pathological diagnosis. However, certain diagnostic aspects remain challenging even for experts.<br><br>CASE PRESENTATION: This report describes a case of a 72-year-old man with a history of asbestos exposure who presented with pleural effusion as the first symptom and was eventually diagnosed as mesothelioma. Mesothelioma was suspected owing to prominent cell-in-cell engulfment in mesothelial cells on the first cytological sample, and the diagnosis of mesothelioma in situ was confirmed by histology. Unexpectedly, sarcomatoid morphology of mesothelioma was found in the second pathology samples 9&#xa0;months after the first pathological examination. Both the mesothelioma in situ and invasive lesion showed immunohistochemical loss of methylthioadenosine phosphorylase (MTAP) and homozygous deletion of cyclin dependent kinase inhibitor 2A (CDKN2A) on fluorescence in situ hybridization. The patient received medication therapy but died of disease progression 12&#xa0;months after the diagnosis of the sarcomatoid morphology of mesothelioma.<br><br>CONCLUSION: Our case suggests that cell-in-cell engulfment can be conspicuous in early-stage mesothelioma with inconspicuous nuclear atypia and few multinucleated cells. In addition, the presence of MTAP loss and CDKN2A homozygous deletion are suspected to be involved in early formation to invasive lesions and/or sarcomatoid morphology. We believe that it is important to consider genetic abnormalities when deciding on individual patient management. Furthermore, cases of mesothelioma, even those of an in situ lesion, with MTAP loss and/or CDKN2A deletion should be carefully followed up or subjected to early treatment.},
}
@article {pmid38015374,
year = {2023},
author = {Nash, A and Creaney, J},
title = {Genomic Landscape of Pleural Mesothelioma and Therapeutic Aftermaths.},
journal = {Current oncology reports},
volume = {25},
number = {12},
pages = {1515-1522},
pmid = {38015374},
issn = {1534-6269},
support = {1197652//National Health and Medical Research Council/ ; CA190450//U.S. Department of Defense/ ; },
mesh = {Humans ; *Lung Neoplasms/genetics/therapy/pathology ; *Mesothelioma, Malignant ; *Mesothelioma/genetics/therapy/pathology ; *Pleural Neoplasms/genetics/therapy/pathology ; Genomics ; Tumor Microenvironment ; },
abstract = {PURPOSE OF REVIEW: In this article, we provide a comprehensive analysis of recent progress in the genetic characterisation of pleural mesothelioma, and the translation of these findings to clinical practice.<br><br>RECENT FINDINGS: Advancements in sequencing technology have allowed the identification of driver mutations and improved our understanding of how these mutations may shape the mesothelioma tumour microenvironment. However, the identification of frequently mutated regions including CDKN2A, BAP1 and NF2 have, to date, not yet yielded targeted therapy options that outperform standard chemo- and immunotherapies. Similarly, the association between mutational profile and the immune microenvironment or immunotherapy response is not well characterised. Further research into the link between tumour mutational profile and response to therapy is critical for identifying targetable vulnerabilities and stratifying patients for therapy.},
}
@article {pmid38002620,
year = {2023},
author = {Sorino, C and Mondoni, M and Marchetti, G and Agati, S and Inchingolo, R and Mei, F and Flamini, S and Lococo, F and Feller-Kopman, D},
title = {Pleural Mesothelioma: Advances in Blood and Pleural Biomarkers.},
journal = {Journal of clinical medicine},
volume = {12},
number = {22},
pages = {},
pmid = {38002620},
issn = {2077-0383},
abstract = {Pleural mesothelioma (PM) is a type of cancer that is highly related to exposure to asbestos fibers. It shows aggressive behavior, and the current therapeutic approaches are usually insufficient to change the poor prognosis. Moreover, apart from staging and histological classification, there are no validated predictors of its response to treatment or its long-term outcomes. Numerous studies have investigated minimally invasive biomarkers in pleural fluid or blood to aid in earlier diagnosis and prognostic assessment of PM. The most studied marker in pleural effusion is mesothelin, which exhibits good specificity but low sensitivity, especially for non-epithelioid PM. Other biomarkers found in pleural fluid include fibulin-3, hyaluronan, microRNAs, and CYFRA-21.1, which have lower diagnostic capabilities but provide prognostic information and have potential roles as therapeutic targets. Serum is the most investigated matrix for biomarkers of PM. Several serum biomarkers in PM have been studied, with mesothelin, osteopontin, and fibulin-3 being the most often tested. A soluble mesothelin-related peptide (SMRP) is the only FDA-approved biomarker in patients with suspected mesothelioma. With different serum and pleural fluid cut-offs, it provides useful information on the diagnosis, prognosis, follow-up, and response to therapy in epithelioid PM. Panels combining different markers and proteomics technologies show promise in terms of improving clinical performance in the diagnosis and monitoring of mesothelioma patients. However, there is still no evidence that early detection can improve the treatment outcomes of PM patients.},
}
@article {pmid38000500,
year = {2024},
author = {Nel, AE and Pavlisko, EN and Roggli, VL},
title = {The Interplay Between the Immune System, Tumor Suppressor Genes, and Immune Senescence in Mesothelioma Development and Response to Immunotherapy.},
journal = {Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
volume = {19},
number = {4},
pages = {551-564},
doi = {10.1016/j.jtho.2023.11.017},
pmid = {38000500},
issn = {1556-1380},
mesh = {Humans ; United States ; Aged ; Phylogeny ; *Lung Neoplasms/genetics/therapy ; *Mesothelioma/genetics/therapy ; *Mesothelioma, Malignant/genetics ; Genes, Tumor Suppressor ; *Asbestos ; Tumor Microenvironment ; },
abstract = {Despite efforts to ban asbestos mining and manufacturing, mesothelioma deaths in the United States have remained stable at approximately 2500 cases annually. This trend is not unique to the United States but is also a global phenomenon, associated with increased aging of populations worldwide. Although geoeconomic factors such as lack of regulations and continued asbestos manufacturing in resource-poor countries play a role, it is essential to consider biological factors such as immune senescence and increased genetic instability associated with aging. Recognizing that mesothelioma shares genetic instability and immune system effects with other age-related cancers is crucial because the impact of aging on mesothelioma is frequently assessed in the context of disease latency after asbestos exposure. Nevertheless, the long latency period, often cited as a reason for mesothelioma's elderly predominance, should not overshadow the shared mechanisms. This communication focuses on the role of immune surveillance in mesothelioma, particularly exploring the impact of immune escape resulting from altered TSG function during aging, contributing to the phylogenetic development of gene mutations and mesothelioma oncogenesis. The interplay between the immune system, TSGs, and aging not only shapes the immune landscape in mesothelioma but also contributes to the development of heterogeneous tumor microenvironments, significantly influencing responses to immunotherapy approaches and survival rates. By understanding the complex interplay between aging, TSG decline, and immune senescence, health care professionals can pave the way for more effective and personalized immunotherapies, ultimately offering hope for better outcomes in the fight against mesothelioma.},
}
@article {pmid37995092,
year = {2023},
author = {Somigliana, AB and Barbieri, PG and Cavallo, A and Colombo, R and Consonni, D and Mirabelli, D},
title = {Lung asbestos fiber burden analysis: effects of the counting rules for legal medicine evaluations.},
journal = {Inhalation toxicology},
volume = {35},
number = {11-12},
pages = {300-307},
doi = {10.1080/08958378.2023.2285789},
pmid = {37995092},
issn = {1091-7691},
mesh = {Humans ; *Asbestos/toxicity/analysis ; Lung/chemistry ; Asbestos, Amphibole/toxicity/analysis ; Asbestos, Serpentine/toxicity ; *Lung Neoplasms ; Forensic Medicine ; },
abstract = {OBJECTIVES: The work shows the effect of counting rules, such as analysis magnification and asbestos fiber dimension to be count (with length ≥5 µm or also asbestos fibers with length <5 µm) in the lung asbestos fiber burden analysis for legal medicine evaluations.<br><br>METHODS: On the same lung tissue samples, two different analyses were carried out to count any asbestos fibers with length &#x2265;1&#x2009;&#xb5;m and with length &#x2265;5&#x2009;&#xb5;m. Results of the amphibole burden of the two analyses were compared by linear regression analysis on log10-transformed values.<br><br>RESULTS: The analysis should be carried out at an appropriate magnification and on samples prepared in such a way as they allow the counting of very fine fibers. If the analysis is limited to the asbestos fibers with length &#x2265;5&#x2009;&#xb5;m, there is a high risk of not detecting possible residual chrysotile fiber burden and thinner crocidolite asbestos fibers.<br><br>CONCLUSIONS: On average we estimated that 1 amphibole fiber with length &#x2265;5&#x2009;&#xb5;m corresponds to &#x223c;8 amphibole fibers with length &#x2265;1&#x2009;&#xb5;m in the lung. The values of the Helsinki criteria should be updated taking this into account.},
}
@article {pmid37977032,
year = {2023},
author = {Salman, A and Abdel Mageed, SS and Fathi, D and Elrebehy, MA and Abulsoud, AI and Elshaer, SS and Khidr, EG and Al-Noshokaty, TM and Khaled, R and Rizk, NI and Elballal, MS and Sayed, GA and Abd-Elmawla, MA and El Tabaa, MM and Mohammed, OA and Ashraf, A and El-Husseiny, AA and Midan, HM and El-Dakroury, WA and Abdel-Reheim, MA and Doghish, AS},
title = {Deciphering signaling pathway interplay via miRNAs in malignant pleural mesothelioma.},
journal = {Pathology, research and practice},
volume = {252},
number = {},
pages = {154947},
doi = {10.1016/j.prp.2023.154947},
pmid = {37977032},
issn = {1618-0631},
mesh = {Humans ; *Mesothelioma, Malignant ; *MicroRNAs/genetics ; *Mesothelioma/diagnosis ; *Pleural Neoplasms/pathology ; Hedgehog Proteins ; *Lung Neoplasms/pathology ; Signal Transduction/genetics ; },
abstract = {Malignant pleural mesothelioma (MPM) is a highly invasive form of lung cancer that adversely affects the pleural and other linings of the lungs. MPM is a very aggressive tumor that often has an advanced stage at diagnosis and a bad prognosis (between 7 and 12 months). When people who have been exposed to asbestos experience pleural effusion and pain that is not explained, MPM should be suspected. After being diagnosed, most MPM patients have a one- to four-year life expectancy. The life expectancy is approximately six months without treatment. Despite the plethora of current molecular investigations, a definitive universal molecular signature has yet to be discovered as the causative factor for the pathogenesis of MPM. MicroRNAs (miRNAs) are known to play a crucial role in the regulation of gene expression at the posttranscriptional level. The association between the expression of these short, non-coding RNAs and several neoplasms, including MPM, has been observed. Although the incidence of MPM is very low, there has been a significant increase in research focused on miRNAs in the past few years. In addition, miRNAs have been found to have a role in various regulatory signaling pathways associated with MPM, such as the Notch signaling network, Wnt/β-catenin, mutation of KRAS, JAK/STAT signaling circuit, protein kinase B (AKT), and Hedgehog signaling pathway. This study provides a comprehensive overview of the existing understanding of the roles of miRNAs in the underlying mechanisms of pathogenic symptoms in MPM, highlighting their potential as viable targets for therapeutic interventions.},
}
@article {pmid37975977,
year = {2023},
author = {John, A and O'Sullivan, H and Popat, S},
title = {Updates in Management of Malignant Pleural Mesothelioma.},
journal = {Current treatment options in oncology},
volume = {24},
number = {12},
pages = {1758-1789},
pmid = {37975977},
issn = {1534-6277},
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/diagnosis/etiology/therapy ; Pemetrexed/therapeutic use ; *Lung Neoplasms/pathology ; *Pleural Neoplasms/diagnosis/etiology/therapy ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; },
abstract = {Malignant pleural mesothelioma (MPM) is an aggressive asbestos-associated thoracic malignancy that is usually incurable. As demonstrated in the landmark MARS2 trial, surgical resection does not improve survival outcomes and its role in managing MPM is limited. Whilst platinum-pemetrexed chemotherapy in combination with bevacizumab was the standard first-line approach for unresectable disease, landmark phase 3 trials have now established the role of immune checkpoint inhibitors (CPIs) in the upfront management of unresectable disease: either nivolumab-ipilimumab or carboplatin-pemetrexed-pembrolizumab. Patient selection for optimal strategy remains an ongoing question. For relapsed disease novel genomic-based therapies targeting a range of aberrations including losses of the tumour suppressor genes BAP1, CDKN2A and NF2, are being evaluated. Nonetheless, the future of MPM therapeutics holds promise. Here we overview current treatment strategies in the management of MPM.},
}
@article {pmid37963950,
year = {2023},
author = {Gun, RT and Kendall, GM},
title = {Asbestos-related cancer in naval personnel: findings from participants in the British nuclear tests 1952-1967.},
journal = {Scientific reports},
volume = {13},
number = {1},
pages = {18842},
pmid = {37963950},
issn = {2045-2322},
mesh = {Humans ; Australia/epidemiology ; *Asbestos/toxicity ; *Mesothelioma/epidemiology/etiology ; *Asbestosis/complications ; *Lung Neoplasms/epidemiology/etiology ; *Occupational Exposure/adverse effects ; *Occupational Diseases/epidemiology ; },
abstract = {Asbestos-containing materials (ACM) were present in British and Australian naval vessels throughout the twentieth century. The aim of this study was to identify and quantify the incidence of cancer in naval personnel from onboard asbestos exposure. Subjects were four cohorts of subjects who had served in the armed forces of the United Kingdom and Australia in the 1950s and 1960s. All cohorts had previously been studied, three of them in relation to radiation exposures from British nuclear testing. Comparisons of SIRs between services were made to identify cancers attributable to asbestos exposure. Excess mesotheliomas were found in naval personnel in all cohorts. In all but one cohort the lung cancer incidence was highest in navy personnel. Comparison of other smoking-related conditions indicated that the excess in navy personnel was not smoking-related. The relatively high SIRs for mesothelioma and the occurrence of deaths from asbestosis were indicative of high levels of asbestos exposure, with an expectation of cases of asbestos-related lung cancer. The findings are consistent with the occurrence of significant excesses of mesotheliomas. In addition, notwithstanding some inconsistencies in the results between the cohorts, we estimated that approximately 27% of lung cancers in Australian seamen and 12% in British seamen were related to onboard asbestos exposure.},
}
@article {pmid37942251,
year = {2023},
author = {Grignani, P and Visonà, SD and Fronda, MV and Borrelli, P and Monti, MC and Bertoglio, B and Conti, A and Fattorini, P and Previderè, C},
title = {The role of single nucleotide polymorphisms related to iron homeostasis in mesothelioma susceptibility after asbestos exposure: a genetic study on autoptic samples.},
journal = {Frontiers in public health},
volume = {11},
number = {},
pages = {1236558},
pmid = {37942251},
issn = {2296-2565},
mesh = {Male ; Humans ; *Mesothelioma, Malignant ; Polymorphism, Single Nucleotide ; *Occupational Exposure ; *Mesothelioma/genetics ; *Asbestos/adverse effects ; Iron/metabolism ; Homeostasis ; Tumor Microenvironment ; },
abstract = {Asbestos-related diseases still represent a major public health problem all over the world. Among them, malignant mesothelioma (MM) is a poor-prognosis cancer, arising from the serosal lining of the pleura, pericardium and peritoneum, triggered by asbestos exposure. Literature data suggest the key role of iron metabolism in the coating process leading to the formation of asbestos bodies, considered to be both protective and harmful. Two sample sets of individuals were taken into consideration, both residing in Broni or neighboring cities (Northwestern Italy) where an asbestos cement factory was active between 1932 and 1993. The present study aims to compare the frequency of six SNPs involved in iron trafficking, previously found to be related to protection/predisposition to MM after asbestos exposure, between 48 male subjects with documented asbestos exposure who died of MM and 48 male subjects who were exposed to asbestos but did not develop MM or other neoplastic respiratory diseases (Non-Mesothelioma Asbestos Exposed - NMAE). The same analysis was performed on 76 healthy male controls. The allelic and genotypic frequencies of a sub-group of 107 healthy Italian individuals contained in the 1000 genomes database were considered for comparison. PCR-multiplex amplification followed by SNaPshot mini-sequencing reaction was used. The findings presented in this study show that the allelic and genotypic frequencies for six SNP markers involved in iron metabolism/homeostasis and the modulation of tumor microenvironment are not significantly different between the two sample sets of MM and NMAE. Therefore, the SNPs here considered do not seem to be useful markers for individual susceptibility to mesothelioma. This finding is not in agreement with previous literature.},
}
@article {pmid37921373,
year = {2023},
author = {Esteban Porcar, A and García Gómez, M and Santana Yllobre, L and Gómez Pajares, F and Esteban Buedo, V and Usó Talamantes, R},
title = {[Reconocimiento del mesotelioma de pleura como enfermedad profesional en la Comunidad Valenciana de 2012 a 2018.].},
journal = {Revista espanola de salud publica},
volume = {97},
number = {},
pages = {},
pmid = {37921373},
issn = {2173-9110},
mesh = {Humans ; Pleura ; Retrospective Studies ; Spain/epidemiology ; *Mesothelioma/epidemiology/etiology ; *Pleural Neoplasms/etiology/complications ; *Occupational Exposure/adverse effects ; *Occupational Diseases/epidemiology/etiology ; },
abstract = {OBJECTIVE: Pleural mesothelioma is a neoplasm almost exclusively attributed to occupational exposure to asbestos and is legally considered an occupational disease. Nevertheless, only a few cases achieve that official recognition. The objective of this work was to describe and analyse this issue, and to identify the major obstacles to its recognition.<br><br>METHODS: A descriptive and retrospective epidemiological study of data was carried out, including figures and some characteristics, of all patients with pleural mesothelioma registered in the official health and labor registries of the Valencian Community from 2012 to 2018, using frequencies, proportions, and incidence rates.<br><br>RESULTS: There were large differences between the two sets of data collected in the different registries, especially regarding the number of cases. During the seven years of data examined, 590 pleural mesotheliomas were diagnosed in the Valencian public health system. Of these, the number of cases that were related to occupational exposure was at least 437. Despite the legal duty of doctors to report such cases, only 31 were reported as suspected occupational disease (7.09%), of which only 13 were ultimately officially recognized as such. It was estimated that the annual economic overcost to the public system of unrecognised patients with this occupational disease by was 2,2270,520 euros.<br><br>CONCLUSIONS: Only a small proportion of occupational mesotheliomas are officially recognized as such. This has important health care and economic repercussions for the individuals involved as well as for the public health system.},
}
@article {pmid37916370,
year = {2023},
author = {Aydogdu, G and Özekinci, S},
title = {Contribution of BAP1 loss and p16 (CDKN2A) deletion analysis to the definitive diagnosis of mesothelioma in effusion cytology.},
journal = {European review for medical and pharmacological sciences},
volume = {27},
number = {20},
pages = {10001-10007},
doi = {10.26355/eurrev_202310_34180},
pmid = {37916370},
issn = {2284-0729},
mesh = {Female ; Humans ; Male ; Middle Aged ; Biomarkers, Tumor/analysis ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor Proteins ; Homozygote ; In Situ Hybridization, Fluorescence ; *Lung Neoplasms/genetics ; *Mesothelioma/diagnosis/genetics/metabolism ; *Mesothelioma, Malignant ; *Pleural Neoplasms ; Sequence Deletion ; Tumor Suppressor Proteins/genetics/analysis ; Ubiquitin Thiolesterase/genetics ; Adult ; Aged ; Aged, 80 and over ; },
abstract = {OBJECTIVE: The cytological diagnosis of mesothelioma is a controversial issue, and definitive diagnosis often requires ancillary tests. The aim of this study was to investigate the contribution of BRCA1-associated protein (1) (BAP1) loss and p16 (CDKN2A) homozygous deletion (HD) on the early diagnosis of mesothelioma in effusion fluids.<br><br>MATERIALS AND METHODS: Between 2019-2022, 21 pleural and peritoneal fluid samples diagnosed with atypical mesothelial proliferation in our institution were included in the study. The slides of the cases that underwent BAP1 immunohistochemistry (IHC) were retrieved from the archive and re-examined. Homozygous deletion (HD) of p16 (CDKN2A) was investigated by the fluorescence in situ hybridization (FISH) method in cell blocks of cytology samples. At least 100 atypical mesothelial cells were counted in each case, and the HD threshold value was >10%.<br><br>RESULTS: The mean age of the cases was 63.47 years (34-90 years), female/male ratio was 3/1. Of the pleural mesothelioma cases, 16 were epithelioid, 2 were biphasic, and 1 were sarcomatoid. Two cases were diagnosed with peritoneal well-differentiated papillary mesothelioma (WDPM). BAP1 loss was observed in 11 (69%) of 16 cases. HD deletion of p16 (CDKN2A) was seen in 11 (58%) patients with FISH. The HD threshold value was 10-20% in 6 of the cases, 30-50% in 3 cases, and above 90% in 2 cases. While HD deletion was observed in p16 (CDKN2A) in all biphasic and sarcomatoid cases (n=3), no deletion was observed in peritoneal WDPM (n=2). Positivity was observed with at least one method in 12 (86%) of 14 pleural mesotheliomas who underwent both BAP1 IHC and p16 (CDKN2A) FISH. Due to technical reasons, the FISH signal could not be obtained in two cell blocks, so no results could be obtained.<br><br>CONCLUSIONS: Asbestos exposure in areas where mesothelioma is endemic and/or the presence of proliferating mesothelial cells in cytological examination are important clues for diagnosis. In controversial cases, BAP1 IHC should be the first step in an ancillary test. Although the FISH method applied to cell blocks has cytology-specific limitations and difficulties, investigating the p16 (CDKN2A) deletion with FISH in selected cases will contribute to the diagnosis.},
}
@article {pmid37901248,
year = {2023},
author = {Qualiotto, AN and Baldavira, CM and Balancin, M and Ab'Saber, A and Takagaki, T and Capelozzi, VL},
title = {Mesothelin expression remodeled the immune-matrix tumor microenvironment predicting the risk of death in patients with malignant pleural mesothelioma.},
journal = {Frontiers in immunology},
volume = {14},
number = {},
pages = {1268927},
pmid = {37901248},
issn = {1664-3224},
mesh = {Humans ; Male ; Female ; *Mesothelioma, Malignant ; B7-H1 Antigen/metabolism ; *Mesothelioma/drug therapy ; Mesothelin ; Tumor Microenvironment ; Collagen Type I ; *Pleural Neoplasms/drug therapy ; *Lung Neoplasms/pathology ; Neoplasm Recurrence, Local ; Risk Factors ; },
abstract = {BACKGROUND: The combination of immunobiological agents with immune checkpoint proteins is a promising treatment for malignant pleural mesothelioma (MPM). Mesothelin and anti-PD-L1 antibody-drug conjugates specifically target malignant neoplastic cells, inhibit the migration and invasion of neoplastic cells, and restore the immune landscape. In this study, we confirmed the importance of mesothelin and examined the relationship between mesothelin and the immune landscape of the tumor microenvironment (TME) in two MPM cohorts.<br><br>METHODS: The discovery cohort included 82 MPM cases. Tissue microarray slides were generated, and samples were processed for hematoxylin &amp; eosin staining, immunohistochemistry, and immunofluorescence assays. The relationship between mesothelin, biomarkers of histogenesis, histological aggressiveness, PD-L1, immune cells (CD4, CD8, CD20, CD68), and collagen type I and type V fibers was evaluated by quantitative digital analyses. The outcome was the survival time until death from disease recurrence. The exploratory cohort included 87 malignant mesothelioma (MESO) patients from The Cancer Genome Atlas database.<br><br>RESULTS: Most patients were male (70.7%) with a history of asbestos exposure (53.7%) and with the epithelioid subtype (89%). Surgical resection was performed in 85.4% of patients, and 14.6% received chemotherapy; 59.8% of patients died from disease extension to the mediastinum. Low tumor mesothelin expression was associated with tumor necrosis and nuclear grade 1, whereas high mesothelin expression was significantly associated with the epithelioid histotype and high density of T cells CD8+, macrophages CD68+, and collagen type I fibers. Cox multivariate analysis showed a high risk of death for non-operated patients [hazard ratio (HR), 3.42 (1.15-10.16)] with low tumor mesothelin levels [HR, 2.58 (1.09-6.10)] and high PD-L1 and low infiltration of T cells CD4+ [HR, 3.81 (1.58-9.18)]. In the exploratory cohort, low mesothelin and high COL1A1 and COL5A1 expression were associated with poor overall survival.<br><br>CONCLUSION: Tumor mesothelin expression associated with the TME immune landscape predicts the risk of death for patients with MPM and could be a new target for immunotherapy in MPM.},
}
@article {pmid37899647,
year = {2023},
author = {Yu, M and Yang, D and Chen, C and Xia, H},
title = {Effects of SETD2 on telomere length and malignant transformation property of Met-5A after one-month crocidolite exposure.},
journal = {Journal of environmental science and health. Part C, Toxicology and carcinogenesis},
volume = {41},
number = {3-4},
pages = {121-134},
doi = {10.1080/26896583.2023.2271822},
pmid = {37899647},
issn = {2689-6591},
mesh = {Humans ; *Aminobenzoates/metabolism/pharmacology ; *Asbestos, Crocidolite/toxicity/metabolism ; Cell Transformation, Neoplastic/chemically induced/metabolism/pathology ; Epithelium/metabolism/pathology ; Naphthalenes/metabolism/pharmacology ; *Histone-Lysine N-Methyltransferase/metabolism ; *Telomere Homeostasis ; },
abstract = {Crocidolite is a carcinogen contributing to the pathogenesis of malignant mesothelioma. This study aimed to characterize the possible telomere-related events mediating the malignant transformation of mesothelial cells with and without SETD2 under crocidolite exposure. The crocidolite concentration resulting in 90% viable SETD2 knockout Met-5A (Met-5A[SETD2-KO]) and Met-5A were estimated to be 0.71 μg/cm[2] and 1.8 μg/cm[2], respectively, during 72 h of exposure, which was further employed in chronical crocidolite exposure during a 72 h exposure interval per time up to 1 month. Chronical crocidolite-exposed Met-5A[SETD2-KO] (chronical Cro-Met-5A[SETD2-KO]) had higher colony formation and increased telomerase reverse transcriptase (TERT) protein levels than chronical crocidolite-exposed Met-5A (chronical Cro-Met-5A) and Met-5A[SETD2-KO]. Chronical Cro-Met-5A[SETD2-KO] had longer telomere length (TL) than chronical Cro-Met-5A, although there were no changes in TL for either chronical Cro-Met-5A or chronical Cro-Met-5A[SETD2-KO] compared with their corresponding cells without crocidolite exposure. BIBR 1532, an inhibitor targeting TERT, partially reduced colony formation and TL for chronical Cro-Met-5A[SETD2-KO], while BIBR 1532 reduced TL but had no effect on colony formation for chronical Cro-Met-5A. Therefore, SETD2 deficient mesothelial cells are susceptible to malignant transformation during chronical crocidolite exposure, and TERT-dependent TL modification likely partially drives SETD2 loss-mediated early onset of mesothelial malignant transformation.},
}
@article {pmid37898984,
year = {2024},
author = {May, IJ and Nowak, AK and Francis, RJ and Ebert, MA and Dhaliwal, SS},
title = {The prognostic value of F18 Fluorothymidine positron emission tomography for assessing the response of malignant pleural mesothelioma to chemotherapy - A prospective cohort study.},
journal = {Journal of medical imaging and radiation oncology},
volume = {68},
number = {1},
pages = {57-66},
doi = {10.1111/1754-9485.13592},
pmid = {37898984},
issn = {1754-9485},
support = {//National Health and Medical Research Council (NHMRC)/ ; },
mesh = {Humans ; *Mesothelioma, Malignant/diagnostic imaging ; Prognosis ; Prospective Studies ; Fluorodeoxyglucose F18 ; Talc ; Radiopharmaceuticals ; Positron-Emission Tomography/methods ; *Mesothelioma/diagnostic imaging/drug therapy ; Positron Emission Tomography Computed Tomography/methods ; },
abstract = {INTRODUCTION: Malignant pleural mesothelioma is difficult to prognosticate. F18-Fluorodeoxyglucose positron emission tomography (FDG PET) shows promise for response assessment but is confounded by talc pleurodesis. F18-Fluorothymidine (FLT) PET is an alternative tracer specific for proliferation. We compared the prognostic value of FDG and FLT PET and determined the influence of talc pleurodesis on these parameters.<br><br>METHODS: Overall, 29 prospectively recruited patients had FLT PET, FDG PET and CT-scans performed prior to and post one chemotherapy cycle; 10 had prior talc pleurodesis. Patients were followed for overall survival. CT response was assessed using mRECIST. Radiomic features were extracted using the MiM software platform. Changes in maximum SUV (SUVmax), mean SUV (SUVmean), FDG total lesion glycolysis (TLG), FLT total lesion proliferation (TLP) and metabolic tumour volume (MTV) after one chemotherapy cycle.<br><br>RESULTS: Cox univariate analysis demonstrated FDG PET radiomics were confounded by talc pleurodesis, and that percentage change in FLT MTV was predictive of overall survival. Cox multivariate analysis showed a 10% increase in FLT tumour volume corresponded with 9.5% worsened odds for overall survival (P&#x2009;=&#x2009;0.028, HR&#x2009;=&#x2009;1.095, 95% CI [1.010, 1.187]). No other variables were significant on multivariate analysis.<br><br>CONCLUSION: This is the first prospective study showing the statistical significance of FLT PET tumour volumes for measuring mesothelioma treatment response. FLT may be better than FDG for monitoring mesothelioma treatment response, which could help optimise mesothelioma treatment regimes.},
}
@article {pmid37894824,
year = {2023},
author = {Leinardi, R and Petriglieri, JR and Pochet, A and Yakoub, Y and Lelong, M and Lescoat, A and Turci, F and Lecureur, V and Huaux, F},
title = {Distinct Pro-Inflammatory Mechanisms Elicited by Short and Long Amosite Asbestos Fibers in Macrophages.},
journal = {International journal of molecular sciences},
volume = {24},
number = {20},
pages = {},
pmid = {37894824},
issn = {1422-0067},
mesh = {Mice ; Animals ; *Asbestos, Amosite/toxicity ; Toll-Like Receptor 4 ; Macrophages ; *Asbestos/toxicity ; Apoptosis ; },
abstract = {While exposure to long amphibolic asbestos fibers (L > 10 µm) results in the development of severe diseases including inflammation, fibrosis, and mesothelioma, the pathogenic activity associated with short fibers (L < 5 µm) is less clear. By exposing murine macrophages to short (SFA) or long (LFA) fibers of amosite asbestos different in size and surface chemistry, we observed that SFA internalization resulted in pyroptotic-related immunogenic cell death (ICD) characterized by the release of the pro-inflammatory damage signal (DAMP) IL-1α after inflammasome activation and gasdermin D (GSDMD)-pore formation. In contrast, macrophage responses to non-internalizable LFA were associated with tumor necrosis factor alpha (TNF-α) release, caspase-3 and -7 activation, and apoptosis. SFA effects exclusively resulted from Toll-like receptor 4 (TLR4), a pattern-recognition receptor (PRR) recognized for its ability to sense particles, while the response to LFA was elicited by a multifactorial ignition system involving the macrophage receptor with collagenous structure (SR-A6 or MARCO), reactive oxygen species (ROS) cascade, and TLR4. Our findings indicate that asbestos fiber size and surface features play major roles in modulating ICD and inflammatory pathways. They also suggest that SFA are biologically reactive in vitro and, therefore, their inflammatory and toxic effects in vivo should not be underestimated.},
}
@article {pmid37889448,
year = {2023},
author = {Lee, FW and Chen, YH and Tran, ND and Lin, CK and Pham, LA},
title = {Association between Asbestos Exposure and the Incidence of Kidney Cancer: a Weight-of-Evidence Evaluation and Meta-analysis.},
journal = {Current environmental health reports},
volume = {10},
number = {4},
pages = {394-409},
pmid = {37889448},
issn = {2196-5412},
mesh = {Humans ; *Mesothelioma/chemically induced/epidemiology ; Incidence ; *Asbestos/toxicity ; Asbestos, Amphibole ; *Occupational Exposure/adverse effects ; *Kidney Neoplasms/chemically induced/epidemiology/complications ; },
abstract = {PURPOSE OF REVIEW: Occupational asbestos exposure has been extensively linked to various cancers, with ongoing debates regarding its association with kidney cancer. This study aims to investigate the correlation between occupational asbestos exposure and kidney cancer incidence. Additionally, potential influencing factors are analyzed to enhance the comprehension of the relationship between asbestos exposure and kidney cancer.<br><br>RECENT FINDING: While asbestos has established strong associations with malignant mesothelioma and lung cancer, its connection to other malignancies such as gastric, colorectal, and kidney cancers remains under scrutiny. The current study presents mixed opinions on the relationship between asbestos exposure and kidney cancer. Our analysis revealed a potential association between asbestos exposure and the incidence of kidney cancer. Notably, among different types of asbestos, exposure to amphibole appeared to be particularly linked to a higher incident risk of kidney cancer.},
}
@article {pmid37880686,
year = {2023},
author = {Carbone, M and Minaai, M and Takinishi, Y and Pagano, I and Yang, H},
title = {Preventive and therapeutic opportunities: targeting BAP1 and/or HMGB1 pathways to diminish the burden of mesothelioma.},
journal = {Journal of translational medicine},
volume = {21},
number = {1},
pages = {749},
pmid = {37880686},
issn = {1479-5876},
support = {R01 CA198138/CA/NCI NIH HHS/United States ; 1R01ES030948-01/ES/NIEHS NIH HHS/United States ; 1R01CA237235-01A1/CA/NCI NIH HHS/United States ; 1R01CA198138/CA/NCI NIH HHS/United States ; R01 ES030948/ES/NIEHS NIH HHS/United States ; },
mesh = {Humans ; *Asbestos/toxicity ; Carcinogenesis ; *HMGB1 Protein ; *Lung Neoplasms/genetics ; *Mesothelioma/epidemiology/therapy ; *Mesothelioma, Malignant/complications ; Tumor Suppressor Proteins/genetics/metabolism ; Ubiquitin Thiolesterase/genetics ; },
abstract = {Mesothelioma is a cancer typically caused by asbestos. Mechanistically, asbestos carcinogenesis has been linked to the asbestos-induced release of HMGB1 from the nucleus to the cytoplasm, where HMGB1 promotes autophagy and cell survival, and to the extracellular space where HMGB1 promotes chronic inflammation and mesothelioma growth. Targeting HMGB1 inhibited asbestos carcinogenesis and the growth of mesothelioma. It is hoped that targeting HMGB1 will be a novel therapeutic strategy that benefits mesothelioma patients. Severe restrictions and/or a complete ban on the use of asbestos were introduced in the 80 and early 90s in the Western world. These measures have proven effective as the incidence of mesothelioma/per 100,000 persons is decreasing in these countries. However, the overall number of mesotheliomas in the Western world has not significantly decreased. There are several reasons for that which are discussed here: (1) the presence of asbestos in old constructions; (2) the development of rural areas containing asbestos or other carcinogenic mineral fibers in the terrain; (3) the discovery of an increasing fraction of mesotheliomas caused by germline genetic mutations of BAP1 and other tumor suppressor genes; (4) mesotheliomas caused by radiation therapy; (5) the overall increase in the population and of the fraction of older people who are much more susceptible to develop all types of cancers, including mesothelioma. In summary, the epidemiology of mesothelioma is changing, the ban on asbestos worked, there are opportunities to help mesothelioma patients especially those who develop in a background of germline mutations and there is the opportunity to prevent a mesothelioma epidemic in the developing world, where the use of asbestos is increasing exponentially. We hope that restrictive measures similar to those introduced in the Western world will soon be introduced in developing countries to prevent a mesothelioma epidemic.},
}
@article {pmid37878258,
year = {2023},
author = {Vimercati, L and Cavone, D and Negrisolo, O and Pentimone, F and De Maria, L and Caputi, A and Sponselli, S and Delvecchio, G and Cafaro, F and Chellini, E and Binazzi, A and Di Marzio, D and Mensi, C and Consonni, D and Migliore, E and Brentisci, C and Martini, A and Negro, C and D'Agostin, F and Grappasonni, I and Pascucci, C and Benfatto, L and Malacarne, D and Casotto, V and Comiati, V and Storchi, C and Mangone, L and Murano, S and Rossin, L and Tallarigo, F and Vitale, F and Verardo, M and Eccher, S and Madeo, G and Staniscia, T and Carrozza, F and Cozzi, I and Romeo, E and Pelullo, P and Labianca, M and Melis, M and Cascone, G and Ferri, GM and Serio, G},
title = {Mesothelioma Risk Among Maritime Workers According to Job Title: Data From the Italian Mesothelioma Register (ReNaM).},
journal = {La Medicina del lavoro},
volume = {114},
number = {5},
pages = {e2023038},
pmid = {37878258},
issn = {0025-7818},
mesh = {Male ; Humans ; *Mesothelioma, Malignant ; *Mesothelioma/epidemiology/etiology ; *Military Personnel ; Italy/epidemiology ; *Asbestos/adverse effects ; },
abstract = {The study describes the 466 cases of malignant mesotheliomas (MM) collected by the National Mesothelioma Register (ReNaM) in Italy in the period 1993-2018 relating to subjects with exclusive asbestos exposure in merchant or military navy. The cases among maritime workers represent 1.8% of the total cases with defined exposure registred in the ReNaM, of which 212 cases (45.4%) among merchant maritime workers and 254 cases (54.5%) among navy. The distribution by site of mesothelioma showed 453 (97.2%) MM cases of the pleura, 11 (2.3%) of the peritoneum and 2 (0.4%) of the tunica vaginalis of the testis. With regard to occupational exposure, it was classified as certain in 318 (68.2%) cases, probable in 69 (14.8%) cases and possible in 79 (16.9%) cases. Among the 23 classified jobs, the highest percentages of certain exposures are among naval engineers, motor mechanics, machine captains and sailors. Machine crew accounted for 49.3% of the cases, deck crew for 27.6%. All cases began exposure on board between 1926 and 1988. Seamen were exposed to asbestos while at sea by virtue of living onboard ships and from continual release of asbestos fibers due to the motion of a vessel. Epidemiological surveillance through the ReNaM has allowed us to verify among cases in the maritime, navy and merchant marine sectors, that in the past, subjects were exposed regardless of the ship's department where have provided service therefore all these cases must be considered as occupational diseases.},
}
@article {pmid37873988,
year = {2023},
author = {Bolgeo, T and Di Matteo, R and Crivellari, S and Gatti, D and Cassinari, A and Riccio, C and De Angelis, A and Delfanti, S and Ferrero, E and Gnani, C and Riili, G and Maconi, A},
title = {Quality of life in patients with PICC diagnosed with mesothelioma: Results of a multicenter epidemiological survey (LifePICC).},
journal = {The journal of vascular access},
volume = {},
number = {},
pages = {11297298231202046},
doi = {10.1177/11297298231202046},
pmid = {37873988},
issn = {1724-6032},
abstract = {BACKGROUND: Pleural mesothelioma (PM) is a rare and aggressive cancer. PICC devices are widely used in cancer patients. The aim of the study is to evaluate the quality of life of patients with PICC diagnosed with PM treated at the Hospital of Casale Monferrato and Alessandria (Italy), an area with a high incidence of asbestos-related diseases.<br><br>STUDY DESIGN AND METHODS: Longitudinal prospective observational study with data collection at PICC insertion (T0), after 3&#x2009;months (T1), 6&#x2009;months (T2), and 9&#x2009;months (T3). Participants were aged >18&#x2009;years, diagnosed with PM, eligible for PICC insertion. Questionnaires used: EORTC QLQ-C30, EORTC QLQ-LC13, and HADS rating scale.<br><br>RESULTS: Twenty-eight patients were enrolled. The mean age was 68.93&#x2009;years (SD 9.13), mostly male (57.1%). The most frequent cancer stage at diagnosis was III (39.3%), then I (32.1%), and IV (21.4%). 85.7% were treated with chemotherapy, 14.3% also with immunotherapy. 96.4% of patients reported no complications during PICC implantation. The perception of health status and quality of life, measured on a scale of 1-7, was in line with an average score of 5 during the evaluation period. The total anxiety and depression score remained normal for most patients (0-7).<br><br>CONCLUSIONS: The PICC management involved a multidisciplinary team with different skills: study findings revealed the key role that dedicated nurses play in PICC placement and ensuring patient problems are promptly addressed. From our study results, PICC placement does not seem to negatively impact the patient's quality of life.},
}
@article {pmid37855384,
year = {2024},
author = {Ferrante, D and Angelini, A and Barbiero, F and Barbone, F and Bauleo, L and Binazzi, A and Bovenzi, M and Bruno, C and Casotto, V and Cernigliaro, A and Ceppi, M and Cervino, D and Chellini, E and Curti, S and De Santis, M and Fazzo, L and Fedeli, U and Fiorillo, G and Franchi, A and Gangemi, M and Giangreco, M and Rossi, PG and Girardi, P and Luberto, F and Massari, S and Mattioli, S and Menegozzo, S and Merlo, DF and Michelozzi, P and Migliore, E and Miligi, L and Oddone, E and Pernetti, R and Perticaroli, P and Piro, S and Addario, SP and Romeo, E and Roncaglia, F and Silvestri, S and Storchi, C and Zona, A and Magnani, C and Marinaccio, A},
title = {Cause specific mortality in an Italian pool of asbestos workers cohorts.},
journal = {American journal of industrial medicine},
volume = {67},
number = {1},
pages = {31-43},
doi = {10.1002/ajim.23546},
pmid = {37855384},
issn = {1097-0274},
support = {//This work was supported by the 'INAIL BRIC project 2019-2021"; INAIL (Piano Ricerca 2016-2018, "Programma Speciale Amianto, BRIC id 55 and BRIC id 59) and 'Asbestos Project' organized by the Italian National Institute of Health (ISS) (Ricerca corrente 2012: Progetto amianto)./ ; },
mesh = {Male ; Humans ; Female ; Cause of Death ; *Mesothelioma/etiology ; Cohort Studies ; *Occupational Exposure/adverse effects ; *Occupational Diseases/etiology ; Construction Materials ; *Asbestos/adverse effects ; *Pleural Neoplasms ; *Peritoneal Neoplasms ; *Ovarian Neoplasms ; Italy/epidemiology ; *Lung Neoplasms/etiology ; },
abstract = {BACKGROUND: Asbestos is a known human carcinogen and is causally associated with malignant mesothelioma, lung, larynx and ovarian cancers.<br><br>METHODS: Cancer risk was studied among a pool of formerly asbestos-exposed workers in Italy. Fifty-two Italian asbestos cohorts (asbestos-cement, rolling-stock, shipbuilding, and other) were pooled and their mortality follow-up was updated to 2018. Standardized mortality ratios (SMRs) were computed for major causes of death considering duration of exposure and time since first exposure (TSFE), using reference rates by region, age and calendar period.<br><br>RESULTS: The study included 63,502 subjects (57,156 men and 6346 women): 40% who were alive, 58% who died (cause known for 92%), and 2% lost to follow-up. Mortality was increased for all causes (SMR: men&#x2009;=&#x2009;1.04, 95% confidence interval [CI] 1.03-1.05; women&#x2009;=&#x2009;1.15, 95% CI 1.11-1.18), all malignancies (SMR: men&#x2009;=&#x2009;1.21, 95% CI 1.18-1.23; women&#x2009;=&#x2009;1.29, 95% CI 1.22-1.37), pleural and peritoneal malignancies (men: SMR&#x2009;=&#x2009;10.46, 95% CI 9.86-11.09 and 4.29, 95% CI 3.66-5.00; women: SMR&#x2009;=&#x2009;27.13, 95% CI 23.29-31.42 and 7.51, 95% CI 5.52-9.98), lung (SMR: men&#x2009;=&#x2009;1.28, 95% CI 1.24-1.32; women&#x2009;=&#x2009;1.26, 95% CI 1.02-1.53), and ovarian cancer (SMR&#x2009;=&#x2009;1.42, 95% CI 1.08-1.84). Pleural cancer mortality increased during the first 40 years of TSFE (latency), reaching a plateau thereafter.<br><br>CONCLUSIONS: Analyses by time-dependent variables showed that the risk for pleural neoplasms increased with latency and no longer increases at long TSFE, consistent with with asbestos clearance from the lungs. Peritoneal neoplasm risk increased over all observation time.},
}
@article {pmid37850051,
year = {2023},
author = {Nishida, S and Toriyama, K and Yomota, M and Hosomi, Y},
title = {Malignant pleural mesothelioma with resolution of pleural effusion.},
journal = {Respirology case reports},
volume = {11},
number = {11},
pages = {e01234},
pmid = {37850051},
issn = {2051-3380},
abstract = {In malignant pleural mesothelioma patients, pleural effusion may improve during the course of the disease. Pleural effusion with nodular shadows bordering the pleura should be followed up even if the pleural effusion improves.},
}
@article {pmid37846453,
year = {2023},
author = {Silvestri, S and Carnevale, F and Cavariani, F and Deidda, B},
title = {[The assessment of asbestos exposure of mesothelioma cases registered in Italy: which problems more than thirty years after the birth of the first regional archives].},
journal = {Epidemiologia e prevenzione},
volume = {47},
number = {4-5},
pages = {298-305},
doi = {10.19191/EP23.4-5.A617.070},
pmid = {37846453},
issn = {1120-9763},
mesh = {Humans ; *Occupational Exposure/adverse effects ; Population Surveillance ; Italy/epidemiology ; Registries ; *Mesothelioma/epidemiology/etiology ; *Mesothelioma, Malignant ; *Asbestos/toxicity ; *Pleural Neoplasms/diagnosis/epidemiology/etiology ; },
abstract = {More than 30 years have passed since the beginning of the epidemiological surveillance of mesothelioma (MM). The Italian National Mesothelioma Register (ReNaM), part of the research department of the National Institute for insurance against industrial injuries (INAIL), has published 7 reports with the description of the cas-es concerning the assessment of diagnoses and exposures to asbestos suffered mainly during working activities but also environmental, in the family premises and during personal activities.Today we are witnessing a reduction in the commitment by some regions which negatively affects those who develop the pathology. Reading the ReNaM reports it emerges, among others, the problem of the delay in reporting new cases which limits the collection of information directly from patients. This contribution, discussing various topics, invites to develop a debate that should allow to update and resolve the critical aspects that arise after decades of activity regarding, in particular, the asbestos exposure assessment. It is the primary interest of the authors to give continuity and improve the ReNaM which remains the most prestigious MM register among those active in other countries.},
}
@article {pmid37846448,
year = {2023},
author = {Angelini, A and Martini, A and Begliomini, B and Silvestri, S},
title = {[Malignant mesothelioma in two married couples exposed to asbestos].},
journal = {Epidemiologia e prevenzione},
volume = {47},
number = {4-5},
pages = {257-262},
doi = {10.19191/EP23.4-5.A623.065},
pmid = {37846448},
issn = {1120-9763},
mesh = {Humans ; Female ; *Mesothelioma, Malignant ; *Mesothelioma/chemically induced/diagnosis/epidemiology ; Spouses ; *Occupational Exposure/adverse effects ; *Pleural Neoplasms/epidemiology ; Italy/epidemiology ; *Asbestos/toxicity ; *Lung Neoplasms/chemically induced/diagnosis/epidemiology ; *Occupational Diseases/epidemiology ; },
abstract = {BACKGROUND: the relationship between past asbestos exposure and the onset of malignant mesothelioma (MM) is well established. However, defining the exposure is not always easy, as it occurs decades before the onset of the disease.<br><br>OBJECTIVES: this report describes four cases of MM diagnosed in two different married couples, both exposed to asbestos fibers: husbands at work and wives for cohabiting and washing their work overalls.<br><br>DESIGN: case report.<br><br>METHODS: the information was collected through interviews using a semi-structured questionnaire and analyzed by occupational hygienists during the activity of epidemiological surveillance of this disease. The results of the mineral content of asbestos fibers performed on lung parenchymal from one of the female cases are available.<br><br>RESULTS: these two cases show a longer latency in the lesser exposed confirming what an occupational epidemiological study has recently highlighted.<br><br>CONCLUSIONS: whenever good quality information collected during interviews are available, skilled occupational hygienists are able to reconstruct past exposures in quali-quantitative terms.},
}
@article {pmid37845104,
year = {2023},
author = {Kaplan, MA and Şendur, MAN and Cangır, AK and Fırat, P and Göker, E and Kılıçkap, S and Oyan, B and Büge Öz, A and Özdemir, F and Özyiğit, G},
title = {Established and new treatment roadmaps for pleural mesothelioma: opinions of the Turkish Collaborative Group.},
journal = {Current problems in cancer},
volume = {47},
number = {6},
pages = {101017},
doi = {10.1016/j.currproblcancer.2023.101017},
pmid = {37845104},
issn = {1535-6345},
mesh = {Humans ; Immunotherapy ; *Mesothelioma/therapy/drug therapy ; Pleura/pathology ; *Pleural Neoplasms/therapy/drug therapy ; Turkey/epidemiology ; },
abstract = {Pleural mesothelioma (PM) is a cancer of the pleural surface, which is aggressive and may be rapidly fatal. PM is a rare cancer worldwide, but is a relatively common disease in Turkey. Asbestos exposure is the main risk factor and the most common underlying cause of the disease. There have been significant improvements in diagnoses and treatments of many malignancies; however, there are still therapeutic challenges in PM. In this review, we aimed to increase the awareness of health care professionals, oncologists, and pulmonologists by underlining the unmet needs of patients with PM and by emphasizing the need for a multidisciplinary treatment and management of PM. After reviewing the general information about PM, we further discuss the treatment options for patients with PM using immunotherapy and offer evidence for improvements in the clinical outcomes of these patients because of these newer treatment modalities.},
}
@article {pmid37813485,
year = {2023},
author = {Marinaccio, A and Di Marzio, D and Mensi, C and Consonni, D and Gioscia, C and Migliore, E and Genova, C and Rossetto Giaccherino, R and Eccher, S and Murano, S and Comiati, V and Casotto, V and Negro, C and Mangone, L and Miligi, L and Piro, S and Angelini, A and Grappasonni, I and Madeo, G and Cozzi, I and Ancona, L and Staniscia, T and Carrozza, F and Cavone, D and Vimercati, L and Labianca, M and Tallarigo, F and Cascone, G and Melis, M and Bonafede, M and Scarselli, A and Binazzi, A},
title = {Incidence of mesothelioma in young people and causal exposure to asbestos in the Italian national mesothelioma registry (ReNaM).},
journal = {Occupational and environmental medicine},
volume = {80},
number = {11},
pages = {603-609},
doi = {10.1136/oemed-2023-108983},
pmid = {37813485},
issn = {1470-7926},
mesh = {Humans ; Adolescent ; Middle Aged ; *Mesothelioma, Malignant/complications ; Incidence ; *Mesothelioma/epidemiology/etiology ; *Asbestos/adverse effects ; *Occupational Exposure/adverse effects ; Italy/epidemiology ; Registries ; *Pleural Neoplasms/epidemiology/etiology ; },
abstract = {INTRODUCTION: The epidemiological surveillance of mesothelioma incidence is a crucial key for investigating the occupational and environmental sources of asbestos exposure. The median age at diagnosis is generally high, according to the long latency of the disease. The purposes of this study are to analyse the incidence of mesothelioma in young people and to evaluate the modalities of asbestos exposure.<br><br>METHODS: Incident malignant mesothelioma (MM) cases in the period 1993-2018 were retrieved from Italian national mesothelioma registry and analysed for gender, incidence period, morphology and exposure. Age-standardised rates have been calculated and the multiple correspondence analysis has been performed. The association between age and asbestos exposure has been tested by &#x3c7;[2] test.<br><br>RESULTS: From 1993 to 2018, 30&#x2009;828 incident MM cases have been collected and 1278 (4.1%) presented diagnosis at early age (&#x2264;50 years). There is a substantial association between age at diagnosis and the type of asbestos exposure and a significantly lower frequency of cases with occupational exposure to asbestos (497 cases vs 701 expected) in young people has been documented. Paraoccupational and environmental exposure to asbestos have been found more frequent in young MM cases (85 and 93 observed cases vs 52 and 44 expected cases, respectively).<br><br>CONCLUSIONS: Mesothelioma incidence surveillance at population level and the anamnestic individual research of asbestos exposure is a fundamental tool for monitoring asbestos exposure health effects, supporting the exposure risks prevention policies. Clusters of mesothelioma incident cases in young people are a significant signal of a potential non-occupational exposure to asbestos.},
}
@article {pmid37824368,
year = {2024},
author = {Tuncel, T and Metintas, M and Güntülü, AK and Güneş, HV},
title = {Whole-Genome Comparative Copy Number Alteration Profiling between Malignant Pleural Mesothelioma and Asbestos-Induced Chronic Pleuritis.},
journal = {Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer},
volume = {43},
number = {1},
pages = {31-44},
doi = {10.1615/JEnvironPatholToxicolOncol.2023047755},
pmid = {37824368},
issn = {2162-6537},
mesh = {Humans ; *Mesothelioma, Malignant ; DNA Copy Number Variations ; *Asbestos/toxicity ; *Pleurisy/genetics ; },
abstract = {Malignant pleural mesothelioma (MPM) is rare and aggressive cancer. The most important risk factor for MPM is exposure to asbestos. In this study, we scanned the genomes of individuals MPM and asbestos-induced chronic pleuritis (AICP) to compare and determine copy number alterations (CNAs) between two asbestos-related diseases. We used high-resolution SNP arrays to compare CNA profiles between MPM (n = 55) and AICP (n = 18). DNAs extracted from pleural tissues in both groups. SNP array analysis revealed common losses at 1p, 3p, 6q, 9p, 13q, 14q, 15q, 16q, 22q and frequent gains at chromosomes 1, 3, 5, 7, 8, and 6p, 12q, 15q, 17p, 20q in MPMs (frequencies max 67%-min 30%; these alterations were not detected in AICPs. Besides detecting well-known MPM-associated CNAs, our high -resolution copy number profiling also detected comparatively rare CNAs for MPMs including losses like 9q33.3, 16q and gains of 1p, 1q, 3p, 3q, 6p, 7q, 15q, 12q, 17p, 20q at significant frequencies in the MPM cohort. We also observed Copy Number gains clustered on the NF2 locus in AICPs, whereas this region was commonly deleted in MPMs. According to this distinct genomic profiles between the two groups, AICPs genomes can be clearly distinguished from highly altered MPM genomes. Hence, we can suggest that SNP arrays can be used as a supporting diagnostic tool in terms of discriminating asbestos-related malignant disease such as MPM and benign pleural lesions, which can be challenging in most instances.},
}
@article {pmid37811036,
year = {2023},
author = {Mehta, K and Mehta, S and Joshi, M and Bharadwaj, HR and Ardeshana, G and Tenkorang, PO},
title = {Challenging diagnosis of sarcomatoid hepatic mesothelioma: a case report with review of literature.},
journal = {Annals of medicine and surgery (2012)},
volume = {85},
number = {10},
pages = {5123-5126},
pmid = {37811036},
issn = {2049-0801},
abstract = {INTRODUCTION: Mesothelioma is a rare and aggressive cancer that is primarily caused by asbestos exposure. However, cases of mesothelioma without asbestos exposure suggest the involvement of other risk factors. Sarcomatoid mesothelioma, which is characterized by spindle-shaped cells, is a particularly aggressive subtype with limited treatment options.<br><br>CASE PRESENTATION: The authors present a case of a 72-year-old man with no history of asbestos exposure who presented with abdominal pain, fatigue, and weight loss. Imaging revealed a large cystic mass in the liver. A Liver biopsy confirmed the diagnosis of sarcomatoid mesothelioma. Immunohistochemistry results further supported this diagnosis. Due to the advanced stage and tumor size, surgical resection was not feasible. Palliative chemotherapy was initiated, but the patient's condition deteriorated rapidly, leading to his demise.<br><br>CONCLUSION: This case highlights the complexity of mesothelioma and the need for further research to identify the nonasbestos-related risk factors. Understanding alternative causative agents and mechanisms is crucial for the early detection, the development of targeted therapies, and improving patient outcomes. The presented case contributes to the existing literature and aligns with the Surgical CAse REport (SCARE) Criteria.},
}
@article {pmid37810608,
year = {2023},
author = {Ramos-Bonilla, JP and Giraldo, M and Marsili, D and Pasetto, R and Terracini, B and Mazzeo, A and Magnani, C and Comba, P and Lysaniuk, B and Cely-García, MF and Ascoli, V},
title = {An Approach to Overcome the Limitations of Surveillance of Asbestos Related Diseases in Low- and Middle-Income Countries: What We Learned from the Sibaté Study in Colombia.},
journal = {Annals of global health},
volume = {89},
number = {1},
pages = {64},
pmid = {37810608},
issn = {2214-9996},
mesh = {Humans ; Colombia/epidemiology ; Developing Countries ; *Occupational Exposure/adverse effects ; *Asbestos ; *Mesothelioma/epidemiology ; *Mesothelioma, Malignant ; *Respiratory Distress Syndrome ; },
abstract = {INTRODUCTION: The asbestos industry began its operations in Colombia in 1942 with the establishment of an asbestos-cement facility in Sibaté, located in the Department of Cundinamarca. Despite extensive asbestos use and production in Colombia, the country lacks a reliable epidemiological surveillance system to monitor the health effects of asbestos exposure. The Colombian health information system, known as SISPRO, did not report mesothelioma cases diagnosed in the municipality, posing a significant challenge in understanding the health impacts of asbestos exposure on the population of Sibaté.<br><br>METHODS: To address this issue, an active surveillance strategy was implemented in Sibat&#xe9;. This strategy involved conducting door-to-door health and socioeconomic structured interviews to identify Asbestos-Related Diseases (ARDs). Validation strategies included a thorough review of medical records by a panel of physicians, and the findings were communicated to local, regional, and national authorities, as well as the general population.<br><br>RESULTS: The active surveillance strategy successfully identified a mesothelioma cluster in Sibat&#xe9;, revealing the inadequacy of the existing health information system in monitoring asbestos-related diseases. The discovery of this cluster underscores the critical importance of implementing active surveillance strategies in Colombia, where governmental institutions and resources are often limited.<br><br>CONCLUSION: The findings of this study emphasize the urgent need for Colombia to establish a reliable epidemiological surveillance system for asbestos-related diseases (ARDs). Active surveillance strategies can play a crucial role in identifying mesothelioma clusters and enhancing our understanding of the health effects of asbestos exposure in low- and middle-income countries.},
}
@article {pmid37802348,
year = {2024},
author = {Takefuji, Y},
title = {An urgent call to action: The absolute necessity to ban asbestos production and sales.},
journal = {The Science of the total environment},
volume = {906},
number = {},
pages = {167557},
doi = {10.1016/j.scitotenv.2023.167557},
pmid = {37802348},
issn = {1879-1026},
mesh = {Humans ; *Occupational Exposure ; *Asbestos ; *Mesothelioma/epidemiology ; Health Policy ; Dust ; },
abstract = {The issue with asbestos highlights the shortcomings in the global management of health policies for dangerous substances. The perils of asbestos dust were identified about a century ago. A significant number of individuals succumb to asbestos-related diseases worldwide annually. A considerable portion of occupational cancer fatalities are believed to be due to asbestos. A large population across the globe is exposed to asbestos in their workplaces. To address issues like asbestos, it is crucial for policymakers to prioritize public interest, and third parties should actively participate in scrutinizing the actions of these policymakers.},
}
@article {pmid37800384,
year = {2023},
author = {Sahin, ER and Koksal, D},
title = {Asbestos: Mineralogical features and fiber analysis in biological materials.},
journal = {Archives of environmental &amp; occupational health},
volume = {78},
number = {6},
pages = {369-378},
doi = {10.1080/19338244.2023.2264764},
pmid = {37800384},
issn = {2154-4700},
mesh = {Humans ; *Asbestos ; *Mesothelioma/chemically induced ; *Asbestosis/etiology ; *Lung Neoplasms/chemically induced ; *Mesothelioma, Malignant/complications ; },
abstract = {Asbestos is a mineral with unique physical and chemical properties that make it highly resistant to heat, fire, and corrosion. Nevertheless, exposure to asbestos fibers has been linked to serious health problems, including lung cancer, mesothelioma, and asbestosis. Despite the ban on asbestos usage, asbestos-related diseases are still a major cause of morbidity and mortality worldwide. Analyzing the mineralogical features and fiber analysis of asbestos in biological materials is critical for scenarios where an asbestos exposure history cannot be obtained, a clinical diagnosis cannot be made, or legal aspects necessitate further investigation. This review outlines the mineralogical features and fiber analysis techniques of asbestos in biological materials.},
}
@article {pmid37793939,
year = {2023},
author = {Ibnian, AM and Khan, OU and Chan, R and Bangalore Lakshminarayana, U and Kiran, F and Abed, S and Abbas, R and Amir, A and Al-Kofahi, NK},
title = {Gelatinous Pleural Effusion: A Diagnostic Challenge for Pleural Mesothelioma in an 80-Year-Old Man.},
journal = {The American journal of case reports},
volume = {24},
number = {},
pages = {e941263},
pmid = {37793939},
issn = {1941-5923},
mesh = {Male ; Humans ; Aged, 80 and over ; *Mesothelioma/diagnosis/pathology ; *Pleural Neoplasms/diagnosis ; *Pleural Effusion/diagnostic imaging/etiology ; Pleura/pathology ; *Asbestos ; *Pleural Diseases ; },
abstract = {BACKGROUND Gelatinous pleural effusion, due to raised hyaluronic acid, can be associated with pleural infection and malignancies, such as tuberculosis, metastatic pleural disease, and mesothelioma. This report is of an 80-year-old man presenting with a gelatinous pleural effusion and diagnosis of pleural mesothelioma. CASE REPORT An 80-year-old man with diabetes mellitus, ischemic heart disease, metastatic prostate cancer, 30-pack-year smoking history, and 5-year history of asbestos exposure (during his 30s), presented with a 4-week history of breathlessness and was found to have right-sided pleural effusion. Thoracic computed tomography (CT) showed mild right-sided pleural thickening. Pleural tap revealed exudative fluid, with a pH of 7.4, and unremarkable cytology and microbiology analyses. The patient was treated for pneumonia and para-pneumonic effusion and discharged home. He came back 5 weeks later with worsening of symptoms and re-accumulation of pleural fluid. Repeated thorax CT showed extensive right-sided pleural lobular thickening. Pleural tap again yielded an exudative fluid, with a pH of 7.37. Cytology and microbiology did not reveal any positive signs for malignancy or infection. This time the pleural fluid appeared gelatinous in consistency. Pleural biopsy showed atypical epithelioid mesothelial cells arranged in trabeculae, with a tubulo-papillary configuration. Also, immunohistochemistry panel showed tumor cells expressed calretinin, EMA, WT1, and D2-40, with negative TTF1, CEA, and BerEp4. Final diagnosis was epithelioid mesothelioma. CONCLUSIONS This report has shown that a gelatinous pleural effusion can be associated with malignant and inflammatory pleural diseases. In this case, imaging and pleural biopsy with histopathology confirmed a diagnosis of pleural mesothelioma.},
}
@article {pmid37730104,
year = {2023},
author = {Schelch, K and Emminger, D and Zitta, B and Johnson, TG and Kopatz, V and Eder, S and Ries, A and Stefanelli, A and Heffeter, P and Hoda, MA and Hoetzenecker, K and Dome, B and Berger, W and Reid, G and Grusch, M},
title = {Targeting YB-1 via entinostat enhances cisplatin sensitivity of pleural mesothelioma in vitro and in vivo.},
journal = {Cancer letters},
volume = {574},
number = {},
pages = {216395},
doi = {10.1016/j.canlet.2023.216395},
pmid = {37730104},
issn = {1872-7980},
support = {DOC 59/FWF_/Austrian Science Fund FWF/Austria ; },
mesh = {*Cisplatin/pharmacology ; Animals ; Humans ; *Pyridines/pharmacology ; *Benzamides/pharmacology ; Cell Line, Tumor ; *Y-Box-Binding Protein 1/metabolism/genetics ; *Pleural Neoplasms/drug therapy/pathology/genetics/metabolism ; *Xenograft Model Antitumor Assays ; *Drug Synergism ; *Mesothelioma/drug therapy/pathology/metabolism/genetics ; Mice ; Cell Proliferation/drug effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacology/therapeutic use ; Mice, Nude ; Antineoplastic Agents/pharmacology ; Acetylation ; Female ; Tumor Suppressor Proteins ; Ubiquitin Thiolesterase ; },
abstract = {Pleural mesothelioma (PM) is characterized by poor prognosis and limited therapeutic options. Y-box-binding protein 1 (YB-1) was shown to drive growth and migration of PM cells. Here, we evaluated the effect of genetic and pharmacological targeting of YB-1 on PM growth and response to cisplatin and radiation treatment. YB-1 knockdown via siRNA resulted in reduced PM cell growth, which significantly correlated with wt BAP1 and mutant NF2 and P53 status. Entinostat inhibited YB-1 deacetylation and its efficacy correlated with YB-1 knockdown-induced growth inhibition in 20 PM cell lines. Tumor growth inhibition by siRNA as well as entinostat was confirmed in mouse xenotransplant models. Furthermore, both YBX1-targeting siRNA and entinostat enhanced sensitivity to cisplatin and radiation. In particular, entinostat showed strong synergistic interactions with cisplatin which was linked to significantly increased cellular platinum uptake in all investigated cell models. Importantly, in a mouse model, the combination of cisplatin and entinostat also resulted in stronger growth inhibition than each treatment alone. Our study highlights YB-1 as an attractive target in PM and demonstrates that targeting YB-1 via entinostat is a promising approach to enhance cisplatin and radiation sensitivity.},
}
@article {pmid37729199,
year = {2023},
author = {Suarez, JS and Novelli, F and Goto, K and Ehara, M and Steele, M and Kim, JH and Zolondick, AA and Xue, J and Xu, R and Saito, M and Pastorino, S and Minaai, M and Takanishi, Y and Emi, M and Pagano, I and Wakeham, A and Berger, T and Pass, HI and Gaudino, G and Mak, TW and Carbone, M and Yang, H},
title = {HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma.},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
volume = {120},
number = {39},
pages = {e2307999120},
pmid = {37729199},
issn = {1091-6490},
support = {R01 CA198138/CA/NCI NIH HHS/United States ; S10 OD028515/OD/NIH HHS/United States ; R01 CA237235/CA/NCI NIH HHS/United States ; U01 CA214195/CA/NCI NIH HHS/United States ; R01 ES030948/ES/NIEHS NIH HHS/United States ; },
mesh = {Animals ; Mice ; *Mesothelioma, Malignant ; Tumor Necrosis Factor-alpha/genetics ; *HMGB1 Protein/genetics ; *Mesothelioma/chemically induced/genetics ; *Asbestos/toxicity ; Inflammation ; Tumor Microenvironment ; },
abstract = {Asbestos is the main cause of malignant mesothelioma. Previous studies have linked asbestos-induced mesothelioma to the release of HMGB1 from the nucleus to the cytoplasm, and from the cytoplasm to the extracellular space. In the cytoplasm, HMGB1 induces autophagy impairing asbestos-induced cell death. Extracellularly, HMGB1 stimulates the secretion of TNFα. Jointly, these two cytokines kick-start a chronic inflammatory process that over time promotes mesothelioma development. Whether the main source of extracellular HMGB1 were the mesothelial cells, the inflammatory cells, or both was unsolved. This information is critical to identify the targets and design preventive/therapeutic strategies to interfere with asbestos-induced mesothelioma. To address this issue, we developed the conditional mesothelial HMGB1-knockout (Hmgb1[ΔpMeso]) and the conditional myelomonocytic-lineage HMGB1-knockout (Hmgb1[ΔMylc]) mouse models. We establish here that HMGB1 is mainly produced and released by the mesothelial cells during the early phases of inflammation following asbestos exposure. The release of HMGB1 from mesothelial cells leads to atypical mesothelial hyperplasia, and in some animals, this evolves over the years into mesothelioma. We found that Hmgb1[ΔpMeso], whose mesothelial cells cannot produce HMGB1, show a greatly reduced inflammatory response to asbestos, and their mesothelial cells express and secrete significantly reduced levels of TNFα. Moreover, the tissue microenvironment in areas of asbestos deposits displays an increased fraction of M1-polarized macrophages compared to M2 macrophages. Supporting the biological significance of these findings, Hmgb1[ΔpMeso] mice showed a delayed and reduced incidence of mesothelioma and an increased mesothelioma-specific survival. Altogether, our study provides a biological explanation for HMGB1 as a driver of asbestos-induced mesothelioma.},
}
@article {pmid37722697,
year = {2024},
author = {Febres-Aldana, CA and Fanaroff, R and Offin, M and Zauderer, MG and Sauter, JL and Yang, SR and Ladanyi, M},
title = {Diffuse Pleural Mesothelioma: Advances in Molecular Pathogenesis, Diagnosis, and Treatment.},
journal = {Annual review of pathology},
volume = {19},
number = {},
pages = {11-42},
doi = {10.1146/annurev-pathol-042420-092719},
pmid = {37722697},
issn = {1553-4014},
mesh = {Humans ; *Mesothelioma ; Risk Factors ; },
abstract = {Diffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our understanding of molecular pathogenesis and transformed our clinical practice. This comprehensive review explores the current concepts and emerging trends in DPM, including risk factors, pathobiology, histologic subtyping, and therapeutic management, with an emphasis on a multidisciplinary approach to this complex disease.},
}
@article {pmid37712235,
year = {2023},
author = {Bruno, C and Di Stefano, R and Ricceri, V and La Rosa, M and Cernigliaro, A and Ciranni, P and Di Maria, G and Mandrioli, D and Zona, A and Comba, P and Scondotto, S},
title = {Fluoro-edenite non-neoplastic diseases in Biancavilla (Sicily, Italy): pleural plaques and/or pneumoconiosis?.},
journal = {Annali dell'Istituto superiore di sanita},
volume = {59},
number = {3},
pages = {187-193},
doi = {10.4415/ANN_23_03_03},
pmid = {37712235},
issn = {2384-8553},
mesh = {Humans ; Sicily/epidemiology ; *Asbestosis/diagnostic imaging/epidemiology ; Asbestos, Amphibole/toxicity ; Italy/epidemiology ; *Pneumoconiosis/diagnostic imaging/epidemiology ; *Mesothelioma/diagnostic imaging/epidemiology ; },
abstract = {BACKGROUND: A mesothelioma cluster in Biancavilla (Sicily, Italy), drew attention to fluoro-edenite, a fibre classified by International Agency for Research on Cancer as carcinogenic to humans. Significant excesses in mortality and morbidity were observed for respiratory diseases and a significant excess of pneumoconiosis hospitalizations was reported.<br><br>OBJECTIVE: Aim of this study is to assess the characters of the lung damage in Biancavilla residents hospitalized with pneumoconiosis or asbestosis diagnoses.<br><br>METHODOLOGY: Medical records, available radiographs and computed tomography scans were collected. The obtained imaging was reviewed by a panel of three specialists and focused on pleural and parenchymal abnormalities. Cases with an ILO-BIT or ICOERD score equal or greater than 2 were considered positive for a pneumoconiosis-like damage, cases with a score lower than 2 or insufficient quality of imaging were considered inconclusive. If no pneumoconiotic aspects were present the cases were classified as negative.<br><br>RESULTS: Out of 38 cases, diagnostic imaging for 25 cases were found. Ten cases out of 25 showed asbestosis-like features, nine subjects were considered negative. In six patients' results were inconclusive.<br><br>CONCLUSIONS: Asbestosis-like features were substantiated in Biancavilla residents without known occupational exposure to asbestos. Further studies to estimate population respiratory health are required. Experimental studies on the fibrogenic potential of fluoro-edenite are needed.},
}
@article {pmid37692737,
year = {2023},
author = {Alsalihi, Y and Kandaswamy, C},
title = {A Worsening Cough: An Unusual Presentation of Malignant Mesothelioma.},
journal = {Cureus},
volume = {15},
number = {8},
pages = {e43205},
pmid = {37692737},
issn = {2168-8184},
abstract = {Localized malignant pleural mesothelioma (LMPM) is a rare cancer with poor survival rates. Often affecting males with asbestos exposure, we report a case of a 56-year-old female with no history of occupational exposure presenting with a worsening cough. A radiological examination revealed left pleural effusion and pleural thickening. Cytological and pathological reports of pleural samples were consistent with malignant mesothelioma of epithelioid type, with the histological examination via video-assisted thoracoscopic surgery (VATS) consistent with a clear cell epithelioid mesothelioma. We discuss the rapid presentation of the disease with emphasis on considering the disease in young patients with no prior asbestos exposure.},
}
@article {pmid37683624,
year = {2023},
author = {Zwijsen, K and Schillebeeckx, E and Janssens, E and Cleemput, JV and Richart, T and Surmont, VF and Nackaerts, K and Marcq, E and van Meerbeeck, JP and Lamote, K},
title = {Determining the clinical utility of a breath test for screening an asbestos-exposed population for pleural mesothelioma: baseline results.},
journal = {Journal of breath research},
volume = {17},
number = {4},
pages = {},
doi = {10.1088/1752-7163/acf7e3},
pmid = {37683624},
issn = {1752-7163},
mesh = {Humans ; Breath Tests ; *Mesothelioma/diagnostic imaging ; *Pleural Neoplasms/diagnostic imaging ; *Asbestos/adverse effects ; *Body Fluids ; },
abstract = {Pleural mesothelioma (PM) is an aggressive cancer of the serosal lining of the thoracic cavity, predominantly caused by asbestos exposure. Due to nonspecific symptoms, PM is characterized by an advanced-stage diagnosis, resulting in a dismal prognosis. However, early diagnosis improves patient outcome. Currently, no diagnostic biomarkers or screening tools are available. Therefore, exhaled breath was explored as this can easily be obtained and contains volatile organic compounds, which are considered biomarkers for multiple (patho)physiological processes. A breath test, which differentiates asbestos-exposed (AEx) individuals from PM patients with 87% accuracy, was developed. However, before being implemented as a screening tool, the clinical utility of the test must be determined. Occupational AEx individuals underwent annual breath tests using multicapillary column/ion mobility spectrometry. A baseline breath test was taken and their individual risk of PM was estimated. PM patients were included as controls. In total, 112 AEx individuals and six PM patients were included in the first of four screening rounds. All six PM patients were correctly classified as having mesothelioma (100% sensitivity) and out of 112 AEx individuals 78 were classified by the breath-based model as PM patients (30% specificity). Given the large false positive outcome, the breath test will be repeated annually for three more consecutive years to adhere to the 'test, re-test' principle and improve the false positivity rate. A low-dose computed tomography scan in those with two consecutive positive tests will correlate test positives with radiological findings and the possible growth of a pleural tumor. Finally, the evaluation of the clinical value of a breath-based prediction model may lead to the initiation of a screening program for early detection of PM in Aex individuals, which is currently lacking. This clinical study received approval from the Antwerp University Hospital Ethics Committee (B300201837007).},
}
@article {pmid37676382,
year = {2024},
author = {Gabelloni, M and Faggioni, L and Brunese, MC and Picone, C and Fusco, R and Aquaro, GD and Cioni, D and Neri, E and Gandolfo, N and Giovagnoni, A and Granata, V},
title = {An overview on multimodal imaging for the diagnostic workup of pleural mesothelioma.},
journal = {Japanese journal of radiology},
volume = {42},
number = {1},
pages = {16-27},
pmid = {37676382},
issn = {1867-108X},
mesh = {Humans ; Neoplasm Staging ; *Mesothelioma/diagnostic imaging/etiology ; *Pleural Neoplasms/diagnostic imaging/pathology ; Risk Factors ; Multimodal Imaging ; },
abstract = {Pleural mesothelioma (PM) is an aggressive disease that has a strong causal relationship with asbestos exposure and represents a major challenge from both a diagnostic and therapeutic viewpoint. Despite recent improvements in patient care, PM typically carries a poor outcome, especially in advanced stages. Therefore, a timely and effective diagnosis taking advantage of currently available imaging techniques is essential to perform an accurate staging and dictate the most appropriate treatment strategy. Our aim is to provide a brief, but exhaustive and up-to-date overview of the role of multimodal medical imaging in the management of PM.},
}
@article {pmid37673586,
year = {2023},
author = {Eastwood, M and Marc, ST and Gao, X and Sailem, H and Offman, J and Karteris, E and Fernandez, AM and Jonigk, D and Cookson, W and Moffatt, M and Popat, S and Minhas, F and Robertus, JL},
title = {Malignant Mesothelioma subtyping via sampling driven multiple instance prediction on tissue image and cell morphology data.},
journal = {Artificial intelligence in medicine},
volume = {143},
number = {},
pages = {102628},
doi = {10.1016/j.artmed.2023.102628},
pmid = {37673586},
issn = {1873-2860},
support = {30731/CRUK_/Cancer Research UK/United Kingdom ; },
mesh = {Humans ; *Mesothelioma, Malignant ; Neural Networks, Computer ; Recognition, Psychology ; },
abstract = {Malignant Mesothelioma is a difficult to diagnose and highly lethal cancer usually associated with asbestos exposure. It can be broadly classified into three subtypes: Epithelioid, Sarcomatoid, and a hybrid Biphasic subtype in which significant components of both of the previous subtypes are present. Early diagnosis and identification of the subtype informs treatment and can help improve patient outcome. However, the subtyping of malignant mesothelioma, and specifically the recognition of transitional features from routine histology slides has a high level of inter-observer variability. In this work, we propose an end-to-end multiple instance learning (MIL) approach for malignant mesothelioma subtyping. This uses an adaptive instance-based sampling scheme for training deep convolutional neural networks on bags of image patches that allows learning on a wider range of relevant instances compared to max or top-N based MIL approaches. We also investigate augmenting the instance representation to include aggregate cellular morphology features from cell segmentation. The proposed MIL approach enables identification of malignant mesothelial subtypes of specific tissue regions. From this a continuous characterisation of a sample according to predominance of sarcomatoid vs epithelioid regions is possible, thus avoiding the arbitrary and highly subjective categorisation by currently used subtypes. Instance scoring also enables studying tumor heterogeneity and identifying patterns associated with different subtypes. We have evaluated the proposed method on a dataset of 234 tissue micro-array cores with an AUROC of 0.89±0.05 for this task. The dataset and developed methodology is available for the community at: https://github.com/measty/PINS.},
}
@article {pmid37667155,
year = {2023},
author = {Yang, YX and Zhang, DK and Lu, HY and Zhao, XL and Yu, H},
title = {[Change trends and related risk factors of disease burden on mesothelioma in Jiangsu Province from 1990 to 2019].},
journal = {Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases},
volume = {41},
number = {8},
pages = {594-600},
doi = {10.3760/cma.j.cn121094-20220815-00400},
pmid = {37667155},
issn = {1001-9391},
support = {H2017018//Medical Research Topic of Jiangsu Commission of Health/ ; },
mesh = {Female ; Male ; Humans ; *Mesothelioma/epidemiology ; *Mesothelioma, Malignant ; Risk Factors ; Cost of Illness ; *Occupational Exposure ; },
abstract = {Objective: To analyze the change trends and risk factors of mesothelioma disease burden in Jiangsu Province from 1990 to 2019. Methods: In January 2022, using the 2019 Global Burden of Disease Study Data, the Joinpoint regression model was used to analyze the change trends of incidence, mortality, disable-adjusted life years (DALY) and premature mortality of mesothelioma residents in Jiangsu Province from 1990 to 2019, and the attribution level of mesothelioma risk factors was estimated by population attributing fraction. Results: The standardized incidence rates of mesothelioma in Jiangsu Province from 1990 to 2019 ranged from 0.07/10(5) to 0.09/10(5), with an average annual percentage change (AAPC) of -1.1% (t=-13.56, P<0.001). AAPCs in males and females were -0.3% (t=-2.18, P=0.029) and -1.6% (t=-11.39, P<0.001), respectively. The standardized mortality rates of mesothelioma ranged from 0.07/10(5) to 0.09/10(5), the AAPC was -1.1% (t=-12.23, P<0.001), AAPC was -1.6% (t=-14.09, P<0.001) for females, and there was no significant change in males (t=-1.83, P=0.068). The premature mortality was 0.004%-0.006%, the AAPC was -1.0% (t=-4.40, P<0.001), AAPC was -1.7% (t=-13.72, P<0.001) for females, and there was no significant change in males (t=-0.68, P=0.495). The standardized DALY rates ranged from 1.86/10(5) to 2.32/10(5), the AAPC was -0.9% (t=-11.08, P<0.001), AAPC was -1.6% (t=-11.05, P<0.001) for females, and there was no significant change in males (t=-0.95, P=0.343). Both the standardized years of life lost (YLL) rate and the standardized years lived with disability (YLD) rate showed a decreasing trend, and the AAPCs were -0.9% (t=-7.66, P<0.001) and -1.0% (t=-12.88, P<0.001), respectively. The proportion of YLL in DALY was more than 98.5%. Among the risk factors for mesothelioma burden attribution, the AAPC attributed to occupational asbestos exposure of DALY was 1.4% (t=3.43, P=0.001). The AAPC of DALY rate of standardized attribution was -1.7% (t=-12.11, P<0.001) . Conclusion: The overall burden of mesothelioma in Jiangsu Province is decreasing, occupational asbestos exposure is still the main risk factor of mesothelioma in Jiangsu Province, and early diagnosis and treatment should be strengthened.},
}
@article {pmid37664365,
year = {2023},
author = {Sousa, B and Silva, J and Monteiro, N and Romano, M and Araújo, E},
title = {Malignant Peritoneal Mesothelioma: A Case Report.},
journal = {Cureus},
volume = {15},
number = {8},
pages = {e42902},
pmid = {37664365},
issn = {2168-8184},
abstract = {Malignant peritoneal mesothelioma (MPM) is a rare tumor of the serous membranes of the peritoneum and has been linked to exposure to asbestos and other risk factors. The clinical manifestations are vague, with a wide clinical spectrum, predominantly related to the abdominal involvement of the disease. Localized mesothelioma is an uncommon manifestation of the disease. Common symptoms include abdominal pain or abdominal distention, nausea, anorexia, and weight loss. Rarely, patients present with paraneoplastic syndrome. Due to the nonspecific symptoms, many patients already have advanced disease at the time of diagnosis. The authors report a case of a 75-year-old female patient who presented with symptoms of asthenia, anorexia, progressive paleness, and weight loss lasting five months. She reports later new-onset symptoms of diffuse abdominal pain and diarrhea associated with nausea. Laboratory tests showed anemia, mild leukocytosis, thrombocytosis, elevated C-reactive protein (CRP), and elevated liver enzymes. An abdominal and pelvic computed tomography (CT) scan revealed marked tissue thickening of an irregular and striated configuration of the leaflets and peritoneal reflections in an omental cake pattern, and a chest CT scan showed multiple bilateral pulmonary nodules, suggesting diffuse malignant disease. A CT-guided biopsy of a peritoneal implant was performed, establishing the diagnosis of malignant peritoneal mesothelioma. Due to rapid clinical deterioration, the patient did not receive any systemic treatment, surgery, or radiotherapy and was transitioned to comfort care. As in the presented case, most cases of MPM have diffuse peritoneal involvement at the time of diagnosis, although extra-abdominal involvement is very rare. This disease presentation is associated with high morbidity and mortality compared to cases of localized disease. There is no specific imaging diagnostic modality or valuable tumor markers for MPM. Although a CT scan remains important in the diagnostic approach, the changes found are not specific. Radiographically, MPM may present as mesenteric or parietal peritoneal nodules, visceral peritoneal thickening, ascites, or omental masses. Although these features may raise suspicion of MPM, a biopsy is necessary to confirm the diagnosis. Therefore, due to the rarity of this disease and its nonspecific signs or symptoms, MPM is difficult to diagnose, and the prognosis remains poor.},
}
@article {pmid37658846,
year = {2023},
author = {Qin, C and Xia, Q and Chen, ZJ and Zhou, Q and Zheng, X},
title = {En bloc resection of the recurrent pleural mesothelioma and reconstruction of the chest wall after immunotherapy: A case report.},
journal = {Thoracic cancer},
volume = {14},
number = {30},
pages = {3063-3066},
pmid = {37658846},
issn = {1759-7714},
mesh = {Female ; Humans ; Adult ; *Mesothelioma, Malignant/pathology ; *Thoracic Wall/surgery/pathology ; Nivolumab ; Ipilimumab ; *Mesothelioma/surgery/pathology ; *Pleural Neoplasms/surgery/pathology ; Immunotherapy ; },
abstract = {Malignant pleural mesothelioma (MPM) is associated with previous asbestos exposure, while more clinical insights into this disease have come from other case studies. Maximal cytoreduction is critical in disease control and might help to improve the prognosis. Here, a 41-year-old female presented with a 6-month history of a mass detected in the chest wall following resection of a right pleural mesothelioma 2 years previously. A fluorodeoxyglucose positron emission tomography/computed tomography scan showed a right chest wall mass with a blurred boundary 8.9 cm × 3.7 cm in size. The patient had received one cycle of bevacizumab, carboplatin, and pemetrexed, and two cycles of nivolumab, ipilimumab, and gemcitabine 5 months before admission. We subsequently resected the tumor, the involved diaphragm, and the fifth and sixth ribs, and titanium mesh and continuous suture were used to close the thoracic cage. The fixed paraffin-embedded tissues showed epithelioid pleural mesothelioma. The patient received nivolumab and ipilimumab postoperatively, and no recurrence was detected 16 months after surgery. En bloc resection with reconstructive surgery effectively removed the locally advanced malignancy and restored the biological function of the thorax with a favorable prognosis. Neoadjuvant immunotherapy might therefore be conducive to radical resection and perioperative immunotherapy might improve the prognosis.},
}
@article {pmid37648326,
year = {2023},
author = {Endo, I and Amatya, VJ and Kushitani, K and Kambara, T and Nakagiri, T and Aoe, K and Takeshima, Y},
title = {FOXM1 Promotes Mesothelioma Cell Migration and Invasion via Activation of SMAD Signaling.},
journal = {Anticancer research},
volume = {43},
number = {9},
pages = {3961-3968},
doi = {10.21873/anticanres.16583},
pmid = {37648326},
issn = {1791-7530},
mesh = {Humans ; *Mesothelioma/genetics ; *Mesothelioma, Malignant ; Carcinogenesis ; Cell Transformation, Neoplastic ; Cell Movement ; Forkhead Box Protein M1/genetics ; },
abstract = {BACKGROUND/AIM: Forkhead box M1 (FOXM1) is a transcription factor closely associated with various human malignancies and is considered an attractive target for cancer therapy. Mesothelioma is a malignancy primarily due to asbestos exposure and certain genetic factors, requiring a better understanding of tumorigenesis for improved treatment. Asbestos-exposed human mesothelial cells have been reported to up-regulate FOXM1 expression in a dose-dependent manner.<br><br>MATERIALS AND METHODS: FOXM1 expression was evaluated in mesothelioma tissues and cell lines. FOXM1 small interfering RNA was transfected into mesothelioma cell lines to analyze its biological functions and regulatory mechanisms.<br><br>RESULTS: FOXM1 was over-expressed in mesothelioma tissues and cell lines. Knock-down of FOXM1 in mesothelioma cell lines inhibited cell proliferation, migration, and invasion. These results suggest that up-regulation of FOXM1 expression promotes mesothelioma tumorigenesis and progression. We previously reported that insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes the proliferation, migration, and invasion of mesothelioma cell lines. In this study, IGF2BP3 knock-down suppressed FOXM1 expression in mesothelioma cell lines. Our results suggest that IGF2BP3, an upstream regulator, contributes to increased FOXM1 expression. Furthermore, IGF2BP3 and FOXM1 knock-down suppressed SMAD signaling by inhibiting SMAD2/3 phosphorylation in mesothelioma cell lines.<br><br>CONCLUSION: IGF2BP3/FOXM1 promotes mesothelioma cell migration and invasion via SMAD signaling, highlighting IGF2BP3/FOXM1 as a potential target for mesothelioma treatment.},
}
@article {pmid37642305,
year = {2023},
author = {Zhang, C and Sun, Q and Zhao, J and Jiang, N and Hao, Y and Luo, J and Karim, S and Wu, L and de Perrot, M and Peng, C and Zhao, X},
title = {JSI-124 inhibits cell proliferation and tumor growth by inducing autophagy and apoptosis in murine malignant mesothelioma.},
journal = {Molecular carcinogenesis},
volume = {62},
number = {12},
pages = {1888-1901},
doi = {10.1002/mc.23623},
pmid = {37642305},
issn = {1098-2744},
support = {//Taishan Mountain Scholars of Shandong Province/ ; //Second hospital of Shandong University/ ; 2022YP104//Youth Talent Innovation Foundation of the Second Hospital of Shandong University/ ; //Special Construction Project Fund for Taishan Mountain Scholars of Shandong Province/ ; },
mesh = {Humans ; Animals ; Mice ; *Mesothelioma, Malignant ; Cell Line, Tumor ; Cell Proliferation ; Apoptosis ; Autophagy ; },
abstract = {Malignant pleural mesothelioma (MPM), mainly caused by asbestos exposure, has a poor prognosis and lacks effective treatment compared with other cancer types. The intracellular transcription factor signal transducer and activator of transcription 3 (STAT3) is overexpressed and hyperactivated in most human cancers. In this study, the role of STAT3 in murine MPM was examined. Inhibition of the Janus kinase 2 (JAK2)/STAT3 pathway with the selective inhibitor JSI-124 has an antitumor effect in murine MPM. Specifically, we demonstrated that JSI-124 inhibits murine MPM cell growth and induces apoptotic and autophagic cell death. Exposure of RN5 and AB12 cells to JSI-124 resulted in apoptosis via the Bcl-2 family of proteins. JSI-124 triggered autophagosome formation, accumulation, and conversion of LC3I to LC3II. Autophagy inhibitors, Chloroquine (CQ) and Bafilomycin A1 (Baf-A1), inhibited autophagy and sensitized RN5 and AB12 cells to JSI-124-induced apoptosis. Our data indicate that JSI-124 is a promising therapeutic agent for MPM treatment.},
}
@article {pmid37637041,
year = {2023},
author = {Deboever, N and Zhou, N and McGrail, DJ and Tomczak, K and Oliva, JL and Feldman, HA and Parra, E and Zhang, J and Lee, PP and Antonoff, MB and Hofstetter, WL and Mehran, RJ and Rajaram, R and Rice, DC and Roth, JA and Swisher, SS and Vaporciyan, AA and Altan, M and Weissferdt, A and Tsao, AS and Haymaker, CL and Sepesi, B},
title = {Radiographic response to neoadjuvant therapy in pleural mesothelioma should serve as a guide for patient selection for cytoreductive operations.},
journal = {Frontiers in oncology},
volume = {13},
number = {},
pages = {1216999},
pmid = {37637041},
issn = {2234-943X},
support = {P30 CA016672/CA/NCI NIH HHS/United States ; },
abstract = {BACKGROUND: Malignant pleural mesothelioma (MPM) is associated with poor prognosis despite advances in multimodal therapeutic strategies. While patients with resectable disease may benefit from added survival with oncologic resection, patient selection for mesothelioma operations often relies on both objective and subjective evaluation metrics. We sought to evaluate factors associated with improved overall survival (OS) in patients with mesothelioma who underwent macroscopic complete resection (MCR).<br><br>METHODS: Patients with MPM who received neoadjuvant therapy and underwent MCR were identified in a prospectively maintained departmental database. Clinicopathologic, blood-based, and radiographic variables were collected and included in a Cox regression analysis (CRA). Response to neoadjuvant therapy was characterized by a change in tumor thickness from pretherapy to preoperative scans using the modified RECIST criteria.<br><br>RESULTS: In this study, 99 patients met the inclusion criteria. The median age of the included patients was 64.7 years, who were predominantly men, had smoking and asbestos exposure, and who received neoadjuvant therapy. The median change in tumor thickness following neoadjuvant therapy was -16.5% (interquartile range of -49.7% to +14.2%). CRA demonstrated reduced OS associated with non-epithelioid histology [hazard ratio (HR): 3.06, 95% confidence interval (CI): 1.62-5.78, p < 0.001] and a response to neoadjuvant therapy inferior to the median (HR: 2.70, CI: 1.55-4.72, p < 0.001). Patients who responded poorly (below median) to neoadjuvant therapy had lower median survival (15.8 months compared to 38.2 months, p < 0.001).<br><br>CONCLUSION: Poor response to neoadjuvant therapy in patients with MPM is associated with poor outcomes even following maximum surgical cytoreduction and should warrant a patient-centered discussion regarding goals of care and may therefore help guide further therapeutic decisions.},
}
@article {pmid37628748,
year = {2023},
author = {Ramundo, V and Zanirato, G and Palazzo, ML and Riganti, C and Aldieri, E},
title = {APE-1/Ref-1 Inhibition Blocks Malignant Pleural Mesothelioma Cell Proliferation and Migration: Crosstalk between Oxidative Stress and Epithelial Mesenchymal Transition (EMT) in Driving Carcinogenesis and Metastasis.},
journal = {International journal of molecular sciences},
volume = {24},
number = {16},
pages = {},
pmid = {37628748},
issn = {1422-0067},
support = {ALDE_RILO_19_01//University of Turin/ ; },
mesh = {Animals ; *Mesothelioma, Malignant ; Epithelial-Mesenchymal Transition ; Oxidative Stress ; Cell Proliferation ; Carcinogenesis ; Hyperplasia ; Endonucleases ; *Hominidae ; },
abstract = {Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with asbestos exposure. MPM pathogenesis has been related both to oxidative stress, evoked by and in response to asbestos fibers exposure, and epithelial mesenchymal transition (EMT), an event induced by oxidative stress itself and related to cancer proliferation and metastasis. Asbestos-related primary oxidative damage is counteracted in the lungs by various redox-sensitive factors, often hyperactivated in some cancers. Among these redox-sensitive factors, Apurinic-apyrimidinic endonuclease 1 (APE-1)/Redox effector factor 1 (Ref-1) has been demonstrated to be overexpressed in MPM and lung cancer, but the molecular mechanism has not yet been fully understood. Moreover, asbestos exposure has been associated with induced EMT events, via some EMT transcription factors, such as Twist, Zeb-1 and Snail-1, in possible crosstalk with oxidative stress and inflammation events. To demonstrate this hypothesis, we inhibited/silenced Ref-1 in MPM cells; as a consequence, both EMT (Twist, Zeb-1 and Snail-1) markers and cellular migration/proliferation were significantly inhibited. Taken as a whole, these results show, for the first time, crosstalk between oxidative stress and EMT in MPM carcinogenesis and invasiveness, thus improving the knowledge to better address a preventive and therapeutic approach against this aggressive cancer.},
}
@article {pmid37626858,
year = {2023},
author = {Fiorilla, I and Martinotti, S and Todesco, AM and Bonsignore, G and Cavaletto, M and Patrone, M and Ranzato, E and Audrito, V},
title = {Chronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma.},
journal = {Cells},
volume = {12},
number = {16},
pages = {},
pmid = {37626858},
issn = {2073-4409},
mesh = {Humans ; *Mesothelioma, Malignant ; Reactive Oxygen Species ; Oxidative Stress ; Carcinogenesis ; Inflammation ; Tumor Microenvironment ; },
abstract = {Malignant pleural mesothelioma (MPM) is a lethal and rare cancer, even if its incidence has continuously increased all over the world. Asbestos exposure leads to the development of mesothelioma through multiple mechanisms, including chronic inflammation, oxidative stress with reactive oxygen species (ROS) generation, and persistent aberrant signaling. Together, these processes, over the years, force normal mesothelial cells' transformation. Chronic inflammation supported by "frustrated" macrophages exposed to asbestos fibers is also boosted by the release of pro-inflammatory cytokines, chemokines, growth factors, damage-associated molecular proteins (DAMPs), and the generation of ROS. In addition, the hypoxic microenvironment influences MPM and immune cells' features, leading to a significant rewiring of metabolism and phenotypic plasticity, thereby supporting tumor aggressiveness and modulating infiltrating immune cell responses. This review provides an overview of the complex tumor-host interactions within the MPM tumor microenvironment at different levels, i.e., soluble factors, metabolic crosstalk, and oxidative stress, and explains how these players supporting tumor transformation and progression may become potential and novel therapeutic targets in MPM.},
}
@article {pmid37608979,
year = {2023},
author = {Moitra, S and Tabrizi, AF and Khadour, F and Henderson, L and Melenka, L and Lacy, P},
title = {Exposure to insulating materials and risk of coronary artery diseases: a cross-sectional study.},
journal = {Frontiers in public health},
volume = {11},
number = {},
pages = {1235189},
pmid = {37608979},
issn = {2296-2565},
mesh = {Adult ; Male ; Humans ; Middle Aged ; Female ; *Coronary Artery Disease/epidemiology/etiology ; Cross-Sectional Studies ; *Heart Diseases ; Heart ; *Mesothelioma, Malignant ; },
abstract = {BACKGROUND: Although previous reports link exposure to insulating materials with an increased risk of mesothelioma and chronic respiratory diseases, studies evaluating their associations with the risk of coronary artery diseases (CAD) are lacking.<br><br>AIMS: We aimed at evaluating the associations between exposure to insulating materials and the 10-year risk of CAD among insulators.<br><br>METHODS: In this cross-sectional study, we recruited 643 adults (&#x2265;18 years), full-time insulators from the Local 110 Heat and Frost Insulators and Allied Workers Union in Edmonton, Alberta. We obtained demographic information, personal and family history, and job-exposure history, including experience (years) and types of exposure to insulating materials. Clinical profiling including Framingham risk scores (FRS) was assessed.<br><br>RESULTS: Of all insulators, 89% were men (mean &#xb1; SD age: 47 &#xb1; 12 years), 27% had a parental history of cardiac diseases, and 22% had a comorbid chronic respiratory disease. In total, 53% reported exposure to asbestos, while 61, 82, and 94% reported exposure to ceramic fibers, fiberglass, and mineral fibers, respectively. In single-exposure multivariable regression models adjusted for experience, marital status, and body mass index (BMI), asbestos was found to be associated with higher FRS (&#x3b2;: 1.004; 95%CI: 0.003-2.00). The association remained consistent in multi-exposure models and a higher association was found between asbestos exposure and FRS among insulators with comorbid chronic respiratory disease.<br><br>CONCLUSION: Our study demonstrates that apart from cancer and chronic respiratory diseases, asbestos exposure may also have a cardiac effect, thus warranting the need for systematic surveillance to protect workers from the adverse effects of these materials.},
}
@article {pmid37605147,
year = {2023},
author = {Welch, H and Harris, J and Pufulete, M and Dimagli, A and Benedetto, U and Maskell, N},
title = {Does previous asbestos exposure increase the risk of a post coronary artery bypass graft (CABG) pleural effusion - a routine data study?.},
journal = {BMC pulmonary medicine},
volume = {23},
number = {1},
pages = {307},
pmid = {37605147},
issn = {1471-2466},
mesh = {Humans ; *Asbestosis/epidemiology ; Prospective Studies ; *Pleural Effusion/epidemiology/etiology ; *Asbestos/adverse effects ; *Pleural Diseases/epidemiology/etiology ; Coronary Artery Bypass/adverse effects ; },
abstract = {BACKGROUND: Development of pleural effusion (PE) following CABG is common. Post-CABG PE are divided into early- (within 30 days of surgery) and delayed-onset (30 days-1 year) which are likely due to distinct pathological processes. Some experts suggest asbestos exposure may confer an independent risk for late-onset post-CABG PE, however no large studies have explored this potential association.<br><br>RESEARCH QUESTION: To explore possible association between asbestos exposure and post-CABG PE using routine data.<br><br>METHODS: All patients who underwent CABG 01/04/2013-31/03/2018 were identified from the Hospital Episode Statistics (HES) Database. This England-wide population was evaluated for evidence of asbestos exposure, pleural plaques or asbestosis and a diagnosis of PE or PE-related procedure from 30 days to 1 year post-CABG. Patients with evidence of PE three months prior to CABG were excluded, as were patients with a new mesothelioma diagnosis.<br><br>RESULTS: 68,150 patients were identified, of whom 1,003 (1%) were asbestos exposed and 2,377 (3%) developed late-onset PE. After adjusting for demographic data, Index of Multiple Deprivation and Charlson Co-morbidity Index, asbestos exposed patients had increased odds of PE diagnosis or related procedure such as thoracentesis or drainage (OR 1.35, 95% CI 1.03-1.76, p&#x2009;=&#x2009;0.04). In those with evidence of PE requiring procedure alone, the adjusted OR was 1.66 (95% CI 1.14-2.40, p&#x2009;=&#x2009;0.01). Additional subgroup analysis of the 518 patients coded for pleural plaques and asbestosis alone revealed an adjusted OR of post-CABG PE requiring a procedure of 2.16 (95% CI 1.38-3.37, p&#x2009;=&#x2009;0.002).<br><br>INTERPRETATION: This large-scale study demonstrates prior asbestos exposure is associated with modestly increased risk of post-CABG PE development. The risk association appears higher in patients with assigned clinical codes indicative of radiological evidence of asbestos exposure (pleural plaques or asbestosis). This association may fit with a possible inflammatory co-pathogenesis, with asbestos exposure 'priming' the pleura resulting in greater propensity for PE evolution following the physiological insult of CABG surgery. Further work, including prospective studies and clinicopathological correlation are suggested to explore this further.},
}
@article {pmid37571934,
year = {2022},
author = {Nasirzadeh, N and Soltanpour, Z and Mohammadian, Y and Pourhasan, B},
title = {Lung Cancer and Pleural Mesothelioma Risk Assessment for the General Population Exposed to Asbestos in Different Regions of Tehran, Iran.},
journal = {Journal of research in health sciences},
volume = {22},
number = {4},
pages = {e00563},
pmid = {37571934},
issn = {2228-7809},
mesh = {Humans ; Iran/epidemiology ; Cross-Sectional Studies ; *Mesothelioma/epidemiology/etiology ; *Asbestos/toxicity ; *Lung Neoplasms/epidemiology/etiology ; *Pleural Neoplasms/epidemiology/etiology ; Risk Assessment ; *Occupational Exposure/adverse effects/analysis ; },
abstract = {BACKGROUND: Asbestos is a natural fiber leading to health risks like chronic lung diseases. The current study aimed to estimate pleural mesothelioma and lung cancer risk for population exposure to asbestos in Tehran, Iran.<br><br>STUDY DESIGN: A cross-sectional study.<br><br>METHODS: According to the annual report of Air Quality Control Company (AQCC), from 2011-2020, carcinogenic risk and mesothelioma were assessed based on the Environmental Protection Agency (EPA) method using the Monte Carlo simulation (MCS). The relative risk (RR) of mortality cancer was calculated based on Camus and colleagues' model. Moreover, mesothelioma risk was estimated by Bourgault and colleagues' model.<br><br>RESULTS: The mean concentration and health risk of asbestos in ambient air generally reduced from 2011 to 2020. The highest mortality risk for lung cancer was 8.4 per 100000 persons in 2011 and reduced to 1.8 in 2017. For mesothelioma, the corresponding values were 8.96 per 100000 persons in 2011 and reduced to 1.92 in 2017.<br><br>CONCLUSION: The findings of this study could be helpful to health policymakers in the management of asbestos risk.},
}
@article {pmid37567753,
year = {2023},
author = {Stella, S and Consonni, D and Migliore, E and Stura, A and Cavone, D and Vimercati, L and Miligi, L and Piro, S and Landi, MT and Caporaso, NE and Curti, S and Mattioli, S and Brandi, G and Gioscia, C and Eccher, S and Murano, S and Casotto, V and Comiati, V and Negro, C and D'Agostin, F and Genova, C and Benfatto, L and Romanelli, A and Grappasonni, I and Madeo, G and Cozzi, I and Romeo, E and Tommaso, S and Carrozza, F and Labianca, M and Tallarigo, F and Cascone, G and Melis, M and Marinaccio, A and Binazzi, A and Mensi, C and , },
title = {Pleural mesothelioma risk in the construction industry: a case-control study in Italy, 2000-2018.},
journal = {BMJ open},
volume = {13},
number = {8},
pages = {e073480},
pmid = {37567753},
issn = {2044-6055},
mesh = {Humans ; Male ; *Construction Industry ; Case-Control Studies ; *Occupational Exposure/adverse effects ; *Occupational Diseases/epidemiology ; *Mesothelioma/epidemiology/etiology ; *Mesothelioma, Malignant ; *Asbestos/adverse effects ; *Pleural Neoplasms/epidemiology/etiology ; Logistic Models ; Italy/epidemiology ; },
abstract = {OBJECTIVES: Workers in the construction industry have been exposed to asbestos in various occupations. In Italy, a National Mesothelioma Registry has been implemented more than 20 years ago. Using cases selected from this registry and exploiting existing control data sets, we estimated relative risks for pleural mesothelioma (PM) among construction workers.<br><br>DESIGN: Case-control study.<br><br>SETTING: Cases from the National Mesothelioma Registry (2000-2018), controls from three previous case-control studies.<br><br>METHODS: We selected male PM incident cases diagnosed in 2000-2018. Population controls were taken from three studies performed in six Italian regions within two periods (2002-2004 and 2012-2016). Age-adjusted and period-adjusted unconditional logistic regression models were fitted to estimate odds ratios (OR) for occupations in the construction industry. We followed two approaches, one (primary) excluding and the other (secondary) including subjects employed in other non-construction blue collar occupations for >5 years. For both approaches, we performed an overall analysis including all cases and, given the incomplete temporal and geographic overlap of cases and controls, three time or/and space restricted sensitivity analyses.<br><br>RESULTS: The whole data set included 15 592 cases and 2210 controls. With the primary approach (4797 cases and 1085 controls), OR was 3.64 (2181 cases) for subjects ever employed in construction. We found elevated risks for blue-collar occupations (1993 cases, OR 4.52), including bricklayers (988 cases, OR 7.05), general construction workers (320 cases, OR 4.66), plumbers and pipe fitters (305 cases, OR 9.13), painters (104 cases, OR 2.17) and several others. Sensitivity analyses yielded very similar findings. Using the secondary approach, we observed similar patterns, but ORs were remarkably lower.<br><br>CONCLUSIONS: We found markedly increased PM risks for most occupations in the construction industry. These findings are relevant for compensation of subjects affected with mesothelioma in the construction industry.},
}
@article {pmid37553196,
year = {2023},
author = {Ferguson, K and Neilson, M and Mercer, R and King, J and Marshall, K and Welch, H and Tsim, S and Maskell, NA and Rahman, NM and Evison, M and Blyth, KG},
title = {Results of the Meso-ORIGINS feasibility study regarding collection of matched benign-mesothelioma tissue pairs by longitudinal surveillance.},
journal = {BMJ open},
volume = {13},
number = {8},
pages = {e067780},
pmid = {37553196},
issn = {2044-6055},
support = {29372/CRUK_/Cancer Research UK/United Kingdom ; },
mesh = {Humans ; Feasibility Studies ; Prospective Studies ; Retrospective Studies ; *Mesothelioma, Malignant ; *Mesothelioma/pathology ; *Pleural Neoplasms/epidemiology ; *Asbestos ; *Lung Neoplasms/pathology ; },
abstract = {OBJECTIVES: To assess key elements of the design for Meso-ORIGINS (Mesothelioma Observational study of RIsk prediction and Generation of paired benign-meso tissue samples, Including a Nested MRI Substudy), an ambitious, UK-wide, prospective study that will collect ≥63 matched benign-mesothelioma tissue pairs through longitudinal surveillance and repeat biopsy of patients with asbestos-associated pleural inflammation (AAPI).<br><br>DESIGN: A multicentre, mixed-methods feasibility study, comprising a prospective observational element, evaluating recruitment feasibility, technical feasibility of repeat local anaesthetic thoracoscopy (LAT) and patient acceptability, and a retrospective cohort study focused on AAPI-mesothelioma evolution rate, informing sample size.<br><br>SETTING: 4 UK pleural disease centres (February 2019-January 2020).<br><br>PARTICIPANTS: Patients with AAPI (history or typical imaging plus appropriate pleural histology) were eligible for both elements. In August 2019, eligibility for the prospective element was broadened, including addition of radiological AAPI for technical feasibility and patient acceptability endpoints only. Retrospective cases required &#x2265;2&#x2009;years follow-up.<br><br>OUTCOME MEASURES: A prospective recruitment target was set a priori at 27 histological AAPI cases (or 14 in any 6&#x2009;months). Technical feasibility and patient acceptability were determined at 6-month follow-up by thoracic ultrasound surrogates and questionnaires, respectively. Retrospective malignant pleural mesothelioma evolution rate was defined by proportion (95%&#x2009;CI). Baseline predictors of evolution were identified using logistic regression.<br><br>RESULTS: 296 patients with AAPI (39 prospective, 257 retrospective) were recruited/selected. 21/39 prospective recruits were histologically diagnosed (target n=27). Repeat LAT was technically feasible and acceptable in 13/28 (46%) and 24/36 (67%) cases with complete follow-up data. Mesothelioma evolution was confirmed histologically in 36/257 retrospective cases (14% (95% CI 10.3% to 18.8%)) and associated with malignant CT features (OR 4.78 (95% CI 2.36 to 9.86)) and age (OR 1.06 (95% CI 1.02 to 1.12)).<br><br>CONCLUSIONS: Our initial eligibility criteria were too narrow. Meso-ORIGINS will recruit a broader cohort, including prevalent cases, any biopsy type and patients with malignant CT features. A range of rebiopsy techniques will be allowed, accounting for technical and patient factors. The sample size has been reduced to 500.<br><br>TRIAL REGISTRATION NUMBER: ISRCTN12840870.},
}
@article {pmid37547483,
year = {2023},
author = {Damiran, N and Frank, AL},
title = {Mongolia: Failure of Total Banning of Asbestos.},
journal = {Annals of global health},
volume = {89},
number = {1},
pages = {50},
pmid = {37547483},
issn = {2214-9996},
mesh = {Humans ; Mongolia ; *Occupational Exposure/adverse effects/prevention &amp; control/analysis ; *Asbestos/toxicity ; *Mesothelioma/epidemiology/prevention &amp; control ; *Mesothelioma, Malignant ; *Lung Neoplasms ; },
abstract = {The primary uses of asbestos in Mongolia are in thermal power plants, construction and at railway companies. There is, however, limited data on both asbestos consumption and asbestos related disease (ARD) in Mongolia. The purpose of this paper is to report on the failure to completely ban asbestos in Mongolia. To write this paper, available asbestos related literature, published nationally and internationally, and legal regulations, national standards and guidelines on asbestos control were reviewed. Mongolia consumed a total of 44,421.9 metric tons of asbestos containing materials (AMCs) between 1996 and 2014. As a key indicator of ARD, 54 cases of mesothelioma were diagnosed at the National Cancer Center by pathological testing of tissue samples between 1994 and 2013. In 2010, The government made the decision to stop all types of asbestos use under the Law on Toxic and Hazardous Substances. However, there was no nationwide action plan to gradually reduce asbestos use, promote substitutes and raise awareness of health hazards and economic burdens in the future from asbestos use. There was also no planning for safe removal of asbestos currently in place. After the banning of asbestos, thermal power plants told the government that they could not produce electricity without insulation of AMCs and substitution materials were economically not feasible. Due to pressure from the energy sector and inadequate awareness of asbestos hazards, the government changed the legal status on asbestos in 2011 as a restricted chemical. Asbestos is still allowed to be used, and workers and the general community are still unnecessarily exposed to this carcinogen.},
}
@article {pmid37529811,
year = {2023},
author = {Kuramochi, M and Muraoka, T and Shinonaga, M and Ohtani, H and Kuraoka, S},
title = {Malignant Pleural Mesothelioma (MPM) Presenting as Hydropneumothorax.},
journal = {Cureus},
volume = {15},
number = {7},
pages = {e41243},
pmid = {37529811},
issn = {2168-8184},
abstract = {An 86-year-old man presented with bilateral lower limb edema and was found to have hydropneumothorax on chest radiography. CT revealed a substantial pleural effusion and plaques. The patient had a history of working in a stone workshop, but the extent of asbestos exposure remained unknown. Thoracic drainage and subsequent thoracoscopic surgery confirmed the presence of biphasic malignant mesothelioma through pathological examination. Hydropneumothorax as a presentation of malignant pleural mesothelioma (MPM) is rare, with only a few similar cases reported. Remarkably, despite the coexistence of plural effusion and pneumothorax, the patient did not experience dyspnea. The examination also revealed tumor rupture and disruption of the pleura. Considering the possibility of MPM in patients with asymptomatic hydropneumothorax is essential for early diagnosis and appropriate management.},
}
@article {pmid37528762,
year = {2023},
author = {Frank, AL},
title = {Four mesothelioma cases from a single automotive dealership: A case series.},
journal = {American journal of industrial medicine},
volume = {66},
number = {10},
pages = {904-906},
doi = {10.1002/ajim.23521},
pmid = {37528762},
issn = {1097-0274},
mesh = {Humans ; Asbestos, Serpentine ; *Lung Neoplasms/etiology ; *Mesothelioma/etiology ; *Asbestos ; *Mesothelioma, Malignant ; *Occupational Exposure/adverse effects ; },
abstract = {BACKGROUND: Four cases of mesothelioma were noted in a workplace of some 110 persons at a tractor dealership between 2006 and 2023. Each worker had a different job title.<br><br>METHODS: Medical-legal case material was reviewed and abstracted from four cases from the same dealership, all supplied via one law firm.<br><br>RESULTS: Four mesotheliomas are reported from this single facility that used chrysotile asbestos automotive products. Two of the four cases had no other known exposures to asbestos.<br><br>DISCUSSION: Automotive products containing chrysotile do appear capable of causing mesothelioma. Job category is not a good surrogate for exposure.},
}
@article {pmid37524680,
year = {2023},
author = {Zhang, GZ and Zheng, GQ and Wei, F and Liu, YY and Song, H and Liang, YF},
title = {[Pathological classification of malignant peritoneal mesothelioma and comparative analysis with peritoneal carcinomatosis].},
journal = {Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases},
volume = {41},
number = {7},
pages = {541-546},
doi = {10.3760/cma.j.cn121094-20211203-00597},
pmid = {37524680},
issn = {1001-9391},
abstract = {Objective: To analyze the pathological classification of malignant peritoneal mesothelioma (MPeM) and screen the immunohistochemical markers that can distinguish MPeM from peritoneal metastatic carcinoma (PC) . Methods: In June 2020, the pathological results of peritoneal biopsy of 158 MPeM and 138 PC patients from Cangzhou Central Hospital, Cangzhou People's Hospital, and Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from May 2011 to July 2019 were retrospectively analyzed, and the pathological classifications of MPeM in Cangzhou were summarized. Immunohistochemical markers of MPeM and PC patients were analyzed, and receiver operating characteristic curve (ROC curve) was drawn for differential diagnosis of MPeM and PC. Results: There were 55 male and 103 female MPeM patients in Cangzhou, with an average age of 57.1 years old. The asbestos exposure rate was 91.14% (144/158). The most common pathological classifications were cutaneous type, accounting for 90.51% (143/158). There were significant differences in the expression of calreticulum protein, CK5/6, vimentin, D2-40, carcinoembryonic antigen (CEA) and tail type homologous nuclear gene transcription factor 2 (CDX-2) between MPeM and PC (P<0.05). Among the 6 positive markers, the sensitivity of calreticulum protein was the highest (0.905) and CEA was the lowest (0.428) . Conclusion: Calreticulum protein, CK5/6, vimentin, D2-40, CEA and CDX-2 may be used as specific markers to distinguish the diagnosis of MPeM from PC.},
}
@article {pmid37517251,
year = {2023},
author = {Rouabeh, W and Cherif, T and Mgarrech, I and Ajmi, N and Kortas, C and Jerbi, S},
title = {Case report and analysis of the literature on sarcomatous mesothelioma of the left atrium.},
journal = {International journal of surgery case reports},
volume = {109},
number = {},
pages = {108537},
pmid = {37517251},
issn = {2210-2612},
abstract = {INTRODUCTION AND IMPORTANCE: Primary intracardiac malignant mesothelioma is an extremely uncommon condition with a terrible prognosis. Because of its rarity, there have been extremely few examples described in the literature.<br><br>CASE PRESENTATION: We are reporting the instance of a 44-year-old lady who was referred to the department of cardiology for worsening dyspnea, palpitations, and a recent syncopal episode. On examination, the patient had signs of global heart failure. Cardiac imaging showed a tissue mass infiltrating the atrioventricular sulcus at the mitral valve level, responsible for severe mitral stenosis. Pleural effusion without an intrapleural mass was also noted. Urgent surgery was performed, including excision of the tumor mass, mechanical replacement of the mitral valve, and tricuspid plasty. The anatomo-pathological study concluded in cardiac mesothelioma. The patient was transferred back to the cardiology department 9&#xa0;months after surgery due to severe left heart failure. TTE and TOE were performed and revealed tumor recurrence responsible for severe mitral stenosis. The course was marked by the onset of cardiogenic shock refractory to treatment, followed by the death of the patient. The case we are reporting seems to be the initial instance documented as exclusively primary intracardiac mesothelioma especially its lack of association with any other pleural sarcomatoid mesothelioma or asbestos exposure.<br><br>CLINICAL DISCUSSION: In cases where a large atrial tumor is present, prompt surgical intervention is recommended to mitigate the risk of catastrophic embolization or valve orifice obstruction. The objective of surgical intervention is to excise the entire neoplasm with sufficient surrounding tissue, a feat that is infrequently achievable. Palliative debulking may be a beneficial intervention for patients who do not necessitate complete resection, particularly those experiencing relevant or rapidly escalating symptoms. Cardiac transplantation remains a viable option in the event of an unresectable malignant tumor.<br><br>CONCLUSION: The short-term prognosis is poor. Surgical treatment remains the best treatment for this type of tumor. Total excision should be considered, but may not be feasible in all cases. Adjuvant chemotherapy may be considered.},
}
@article {pmid37483507,
year = {2023},
author = {Wang, J and Huang, X and Ma, R and Zhang, Q and Wu, N and Du, X and Ye, Q},
title = {The incidence of malignancies in asbestosis with chrysotile exposure: a large Chinese prospective cohort study.},
journal = {Frontiers in oncology},
volume = {13},
number = {},
pages = {1172496},
pmid = {37483507},
issn = {2234-943X},
abstract = {BACKGROUND: Asbestos exposure is closely related to the occurrence and development of various malignancies. This prospective cohort study aimed to evaluate the incidence rate and potential risk factors in a cohort of asbestosis patients in China.<br><br>METHODS: The incidence of malignancies was determined in patients who had been exposed to chrysotile asbestos and diagnosed with asbestosis sequentially at Beijing Chaoyang Hospital from 1 January 2007 to 31 December 2019. Cox regression analyses were used to analyze the correlations between clinical variables and asbestosis combined with malignancies.<br><br>RESULTS: A total of 618 patients with asbestosis were identified, of whom 544 were eligible for analysis. Among them, 89 (16.36%) were diagnosed with various malignancies. The standardized incidence ratios (SIRs) of patients with asbestosis combined with malignancies were 16.61, 175, 5.23, and 8.77 for lung cancer, mesothelioma, breast cancer, and endometrial carcinoma, respectively. The risks of all malignancies and lung cancer increased with initial exposure before 17 years old, longer asbestos exposure, and smoking.<br><br>CONCLUSIONS: The SIRs of patients with asbestosis-related malignancies were significantly increased in lung cancer, mesothelioma, breast cancer, and endometrial carcinoma in a hospital-based Chinese cohort. Smoking and the duration of asbestos exposure increased the risk of lung cancer.},
}
@article {pmid37476375,
year = {2023},
author = {Shi, H and Zhang, L and Yu, TK and Zhuang, L and Ke, H and Johnson, B and Rath, E and Lee, K and Klebe, S and Kao, S and Qin, KL and Pham, HNT and Vuong, Q and Cheng, YY},
title = {Leptospermum extract (QV0) suppresses pleural mesothelioma tumor growth in vitro and in vivo by mitochondrial dysfunction associated apoptosis.},
journal = {Frontiers in oncology},
volume = {13},
number = {},
pages = {1162027},
pmid = {37476375},
issn = {2234-943X},
abstract = {Pleural mesothelioma (PM) is a highly aggressive, fast-growing asbestos-induced cancer with limited effective treatments. There has been interest in using naturally occurring anticancer agents derived from plant materials for the treatment of PM. However, it is unclear if an aqueous extract from Leptospermum polygalifolium (QV0) has activity against PM. Here we investigated the anti-cancer properties of QV0 and Defender[®] (QV0 dietary formula) in vitro and in vivo, respectively. QV0 suppressed the growth of eight PM cell lines in a dose-dependent manner, effective at concentrations as low as 0.02% w/v (equivalent to 0.2 mg/ml). This response was found to be associated with inhibited cell migration, proliferation, and colony formation but without evident cell cycle alteration. We observed mitochondrial dysfunction post-QV0 treatment, as evidenced by significantly decreased basal and maximal oxygen consumption rates. Ten SCID mice were treated with 0.25 mg/g Defender[®] daily and exhibited reduced tumor size over 30 days, which was associated with an average extension of seven days of mouse life. There was no evidence of liver toxicity or increased blood glucose post-treatment in animals treated with Defender[®]. Significantly enhanced tumor apoptosis was observed in the Defender[®]-treated animals, correlating to mitochondrial dysfunction. Lastly, the high levels of polyphenols and antioxidant properties of QV0 and Defender[®] were detected in HPLC analysis. To the best of our knowledge, this study constitutes the first demonstration of an improved host survival (without adverse effects) response in a QV0-treated PM mouse model, associated with evident inhibition of PM cell growth and mitochondrial dysfunction-related enhancement of tumor apoptosis.},
}
@article {pmid37469419,
year = {2023},
author = {Sahu, RK and Ruhi, S and Jeppu, AK and Al-Goshae, HA and Syed, A and Nagdev, S and Widyowati, R and Ekasari, W and Khan, J and Bhattacharjee, B and Goyal, M and Bhattacharya, S and Jangde, RK},
title = {Malignant mesothelioma tumours: molecular pathogenesis, diagnosis, and therapies accompanying clinical studies.},
journal = {Frontiers in oncology},
volume = {13},
number = {},
pages = {1204722},
pmid = {37469419},
issn = {2234-943X},
abstract = {The pathetic malignant mesothelioma (MM) is a extremely uncommon and confrontational tumor that evolves in the mesothelium layer of the pleural cavities (inner lining- visceral pleura and outer lining- parietal pleura), peritoneum, pericardium, and tunica vaginalis and is highly resistant to standard treatments. In mesothelioma, the predominant pattern of lesions is a loss of genes that limit tumour growth. Despite the worldwide ban on the manufacture and supply of asbestos, the prevalence of mesothelioma continues to increase. Mesothelioma presents and behaves in a variety of ways, making diagnosis challenging. Most treatments available today for MM are ineffective, and the median life expectancy is between 10 and 12 months. However, in recent years, considerable progress has already been made in understanding the genetics and molecular pathophysiology of mesothelioma by addressing hippo signaling pathway. The development and progression of MM are related to many important genetic alterations. This is related to NF2 and/or LATS2 mutations that activate the transcriptional coactivator YAP. The X-rays, CT scans, MRIs, and PET scans are used to diagnose the MM. The MM are treated with surgery, chemotherapy, first-line combination chemotherapy, second-line treatment, radiation therapy, adoptive T-cell treatment, targeted therapy, and cancer vaccines. Recent clinical trials investigating the function of surgery have led to the development of innovative approaches to the treatment of associated pleural effusions as well as the introduction of targeted medications. An interdisciplinary collaborative approach is needed for the effective care of persons who have mesothelioma because of the rising intricacy of mesothelioma treatment. This article highlights the key findings in the molecular pathogenesis of mesothelioma, diagnosis with special emphasis on the management of mesothelioma.},
}
@article {pmid37466108,
year = {2023},
author = {Lombardo, C and Broggi, G and Vitale, E and Ledda, C and Loreto, C and Matera, S and Hagnas, M and Caltabiano, R and Filetti, V},
title = {Expression of stathmin in asbestos-like fibers-induced mesothelioma: A preliminary report.},
journal = {Histology and histopathology},
volume = {38},
number = {11},
pages = {1249-1256},
pmid = {37466108},
issn = {1699-5848},
support = {2020/2022//Interdepartment "PIA.CE.RI" Research Plan of University of Catania/ ; },
mesh = {Humans ; *Asbestos/toxicity/analysis ; Biomarkers/analysis ; *Lung Neoplasms/pathology ; *Mesothelioma/diagnosis/metabolism ; *Mesothelioma, Malignant ; Sicily ; Stathmin ; },
abstract = {BACKGROUND: Mesothelioma is strongly associated with exposure to asbestos fibers, however, recent studies have also linked exposure to "naturally occurring asbestos" fibers with this disease. Fluoro-edenite, a silicate mineral found in the southeast of Biancavilla (Sicily, Italy), has been identified as a potential risk factor for mesothelioma. Unfortunately, this cancer often has a poor prognosis, and current diagnostic and prognostic biomarkers are inadequate. Histological subtype, gender, and age at diagnosis are the most significant parameters for mesothelioma. Stathmin, a cytosolic protein that regulates cell growth and migration and is overexpressed in many human malignancies, has not yet been linked to mesothelioma survival or clinical-pathological variables.<br><br>AIM: The aim of this study was to investigate the immunohistochemical expression of stathmin in ten mesothelioma tissue samples with available clinical and follow-up data.<br><br>MATERIAL AND METHODS: Paraffin-embedded tissue samples from ten mesothelioma patients were processed for immunohistochemical analyses to evaluate stathmin expression.<br><br>RESULTS: Our findings suggest that stathmin overexpression is associated with shorter overall survival in patients with mesothelioma. Furthermore, stathmin expression was significantly correlated with the survival time of mesothelioma patients.<br><br>CONCLUSION: Our results suggest that stathmin expression may serve as a potential prognostic biomarker for mesothelioma. This biomarker could be used to promptly identify patients with poor prognosis and to guide clinicians in the selection of treatment options.},
}
@article {pmid37460925,
year = {2023},
author = {Torricelli, F and Donati, B and Reggiani, F and Manicardi, V and Piana, S and Valli, R and Lococo, F and Ciarrocchi, A},
title = {Spatially resolved, high-dimensional transcriptomics sorts out the evolution of biphasic malignant pleural mesothelioma: new paradigms for immunotherapy.},
journal = {Molecular cancer},
volume = {22},
number = {1},
pages = {114},
pmid = {37460925},
issn = {1476-4598},
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/genetics/therapy ; Transcriptome ; Ecosystem ; *Pleural Neoplasms/genetics/therapy ; *Lung Neoplasms/genetics ; Prognosis ; Biomarkers, Tumor/genetics ; Immunotherapy ; },
abstract = {BACKGROUND: Malignant Pleural Mesothelioma (MPM) is a dreadful disease escaping the classical genetic model of cancer evolution and characterized by wide heterogeneity and transcriptional plasticity. Clinical evolution of MPM is marked by a progressive transdifferentiation that converts well differentiated epithelioid (E) cells into undifferentiated and pleomorphic sarcomatoid (S) phenotypes. Catching the way this transition takes place is necessary to understand how MPM develops and progresses and it is mandatory to improve patients' management and life expectancy. Bulk transcriptomic approaches, while providing a significant overview, failed to resolve the timing of this evolution and to identify the hierarchy of molecular events through which this transition takes place.<br><br>METHODS: We applied a spatially resolved, high-dimensional transcriptomic approach to study MPM morphological evolution. 139 regions across 8 biphasic MPMs (B-MPMs) were profiled using the GeoMx&#x2122;Digital Spatial Profiler to reconstruct the positional context of transcriptional activities and the spatial topology of MPM cells interactions. Validation was conducted on an independent large cohort of 84 MPMs by targeted digital barcoding analysis.<br><br>RESULTS: Our results demonstrated the existence of a complex circular ecosystem in which, within a strong asbestos-driven inflammatory environment, MPM and immune cells affect each other to support S-transdifferentiation. We also showed that TGFB1 polarized M2-Tumor Associated Macrophages foster immune evasion and that TGFB1 expression correlates with reduced survival probability.<br><br>CONCLUSIONS: Besides providing crucial insights into the multidimensional interactions governing MPM clinical evolution, these results open new perspectives to improve the use of immunotherapy in this disease.},
}
@article {pmid37441092,
year = {2023},
author = {Farahmand, P and Gyuraszova, K and Rooney, C and Raffo-Iraolagoitia, XL and Jayasekera, G and Hedley, A and Johnson, E and Chernova, T and Malviya, G and Hall, H and Monteverde, T and Blyth, K and Duffin, R and Carlin, LM and Lewis, D and Le Quesne, J and MacFarlane, M and Murphy, DJ},
title = {Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma.},
journal = {Frontiers in toxicology},
volume = {5},
number = {},
pages = {1200650},
pmid = {37441092},
issn = {2673-3080},
support = {23983/CRUK_/Cancer Research UK/United Kingdom ; 25006/CRUK_/Cancer Research UK/United Kingdom ; MC_UU_00025/5/MRC_/Medical Research Council/United Kingdom ; },
abstract = {Hypothesis: Asbestos-driven inflammation contributes to malignant pleural mesothelioma beyond the acquisition of rate-limiting mutations. Methods: Genetically modified conditional allelic mice that were previously shown to develop mesothelioma in the absence of exposure to asbestos were induced with lentiviral vector expressing Cre recombinase with and without intrapleural injection of amosite asbestos and monitored until symptoms required euthanasia. Resulting tumours were examined histologically and by immunohistochemistry for expression of lineage markers and immune cell infiltration. Results: Injection of asbestos dramatically accelerated disease onset and end-stage tumour burden. Tumours developed in the presence of asbestos showed increased macrophage infiltration. Pharmacological suppression of macrophages in mice with established tumours failed to extend survival or to enhance response to chemotherapy. Conclusion: Asbestos-driven inflammation contributes to the severity of mesothelioma beyond the acquisition of rate-limiting mutations, however, targeted suppression of macrophages in established epithelioid mesothelioma showed no therapeutic benefit.},
}
@article {pmid37421230,
year = {2024},
author = {Jama, M and Zhang, M and Poile, C and Nakas, A and Sharkey, A and Dzialo, J and Dawson, A and Kutywayo, K and Fennell, DA and Hollox, EJ},
title = {Gene fusions during the early evolution of mesothelioma correlate with impaired DNA repair and Hippo pathways.},
journal = {Genes, chromosomes &amp; cancer},
volume = {63},
number = {1},
pages = {e23189},
doi = {10.1002/gcc.23189},
pmid = {37421230},
issn = {1098-2264},
support = {//British Lung Foundation/ ; //Mesothelioma UK/ ; },
mesh = {Humans ; *Mesothelioma, Malignant/genetics ; Hippo Signaling Pathway ; *Lung Neoplasms/genetics/pathology ; *Mesothelioma/genetics ; *Asbestos ; DNA Repair/genetics ; Gene Fusion ; },
abstract = {Malignant pleural mesothelioma (MPM), a rare cancer a long latency period (up to 40 years) between asbestos exposure and disease presentation. The mechanisms coupling asbestos to recurrent somatic alterations are poorly defined. Gene fusions arising through genomic instability may create novel drivers during early MPM evolution. We explored the gene fusions that occurred early in the evolutionary history of the tumor. We conducted multiregional whole exome sequencing (WES) of 106 samples from 20 patients undergoing pleurectomy decortication and identified 24 clonal nonrecurrent gene fusions, three of which were novel (FMO9P-OR2W5, GBA3, and SP9). The number of early gene fusion events detected varied from zero to eight per tumor, and presence of gene fusions was associated with clonal losses involving the Hippo pathway genes and homologous recombination DNA repair genes. Fusions involved known tumor suppressors BAP1, MTAP, and LRP1B, and a clonal oncogenic fusion involving CACNA1D-ERC2, PARD3B-NT5DC2, and STAB2-NT5DC2 fusions were also identified as clonal fusions. Gene fusions events occur early during MPM evolution. Individual fusions are rare as no recurrent truncal fusions event were found. This suggests the importance of early disruption of these pathways in generating genomic rearrangements resulting in potentially oncogenic gene fusions.},
}
@article {pmid37399948,
year = {2023},
author = {Coccè, V and Bonelli, M and La Monica, S and Alfieri, R and Doneda, L and Martegani, E and Alessandri, G and Lagrasta, CA and Giannì, A and Sordi, V and Petrella, F and Roncoroni, L and Paino, F and Pessina, A},
title = {Mesenchymal stromal cells loaded with Paclitaxel (PacliMES) a potential new therapeutic approach on mesothelioma.},
journal = {Biochemical pharmacology},
volume = {214},
number = {},
pages = {115678},
doi = {10.1016/j.bcp.2023.115678},
pmid = {37399948},
issn = {1873-2968},
mesh = {Humans ; Paclitaxel ; *Mesothelioma, Malignant ; Cell Line, Tumor ; *Mesothelioma/drug therapy ; *Mesenchymal Stem Cells ; },
abstract = {Malignant pleural mesothelioma is an asbestos-related tumor originating in mesothelial cells of the pleura that poorly responds to chemotherapeutic approaches. Adult mesenchymal stromal cells derived either from bone marrow or from adipose tissue may be considered a good model for cell-based therapy, a treatment which has experienced significant interest in recent years. The present study confirms that Paclitaxel is effective on mesothelioma cell proliferation in 2D and 3D in vitro cultures, and that 80,000 mesenchymal stromal cells loaded with Paclitaxel inhibit tumor growth at a higher extent than Paclitaxel alone. An in vivo approach to treat in situ mesothelioma xenografts using a minimal amount of 10[6] mesenchymal stromal cells loaded with Paclitaxel showed the same efficacy of a systemic administration of 10 mg/kg of Paclitaxel. These data strongly support drug delivery system by mesenchymal stromal cells as a useful approach against many solid tumors. We look with interest at the favourable opinion recently expressed by the Italian Drug Agency on the procedure for the preparation of mesenchymal stromal cells loaded with Paclitaxel in large-scale bioreactor systems and their storage until clinical use. This new Advanced Medicinal Therapy Product, already approved for a Phase I clinical trial on mesothelioma patients, could pave the way for mesenchymal stromal cells use as drug delivery system on other solid tumors for adjuvant therapy associated with surgery and radiotherapy.},
}
@article {pmid37398648,
year = {2023},
author = {Digifico, E and Erreni, M and Mannarino, L and Marchini, S and Ummarino, A and Anfray, C and Bertola, L and Recordati, C and Pistillo, D and Roncalli, M and Bossi, P and Zucali, PA and D'Incalci, M and Belgiovine, C and Allavena, P},
title = {Important functional role of the protein osteopontin in the progression of malignant pleural mesothelioma.},
journal = {Frontiers in immunology},
volume = {14},
number = {},
pages = {1116430},
pmid = {37398648},
issn = {1664-3224},
mesh = {Animals ; Humans ; Mice ; Cytokines/therapeutic use ; *Mesothelioma/drug therapy ; *Mesothelioma, Malignant ; *Osteopontin/genetics/metabolism ; *Pleural Neoplasms/drug therapy ; },
abstract = {BACKGROUND: Malignant Pleural Mesothelioma (MPM) is an aggressive cancer of the mesothelial lining associated with exposure to airborne non-degradable asbestos fibers. Its poor response to currently available treatments prompted us to explore the biological mechanisms involved in its progression. MPM is characterized by chronic non-resolving inflammation; in this study we investigated which inflammatory mediators are mostly expressed in biological tumor samples from MPM patients, with a focus on inflammatory cytokines, chemokines and matrix components.<br><br>METHODS: Expression and quantification of Osteopontin (OPN) was detected in tumor and plasma samples of MPM patients by mRNA, immunohistochemistry and ELISA. The functional role of OPN was investigated in mouse MPM cell lines in vivo using an orthotopic syngeneic mouse model.<br><br>RESULTS: In patients with MPM, the protein OPN was significantly more expressed in tumors than in normal pleural tissues and predominantly produced by mesothelioma cells; plasma levels were elevated in patients and associated with poor prognosis. However, modulation of OPN levels was not significantly different in a series of 18 MPM patients receiving immunotherapy with durvalumab alone or with pembrolizumab in combination with chemotherapy, some of whom achieved a partial clinical response. Two established murine mesothelioma cell lines: AB1 and AB22 of sarcomatoid and epithelioid histology, respectively, spontaneously produced high levels of OPN. Silencing of the OPN gene (Spp1) dramatically inhibited tumor growth in vivo in an orthotopic model, indicating that OPN has an important promoting role in the proliferation of MPM cells. Treatment of mice with anti-CD44 mAb, blocking a major OPN receptor, significantly reduced tumor growth in vivo.<br><br>CONCLUSION: These results demonstrate that OPN is an endogenous growth factor for mesothelial cells and inhibition of its signaling may be helpful to restrain tumor progression in vivo. These findings have translational potential to improve the therapeutic response of human MPM.},
}
@article {pmid37361656,
year = {2023},
author = {Mishra, K and Siddiquee, S and Mislang, AR},
title = {A rare presentation of malignant mesothelioma of the tunica vaginalis managed with immunotherapy and review of the literature.},
journal = {Clinical case reports},
volume = {11},
number = {6},
pages = {e7610},
pmid = {37361656},
issn = {2050-0904},
abstract = {KEY CLINICAL MESSAGE: We describe the first case in literature of malignant mesothelioma of the tunica vaginalis that has shown partial response to systemic immunotherapy (ipilimumab-nivolumab) post orchiectomy, warranting further investigation in a trial setting.<br><br>ABSTRACT: We present a case report of an 80-year-old ex-smoker with a rare diagnosis of metastatic mesothelioma of the tunica vaginalis, managed with immunotherapy. The patient, with no known history of asbestos exposure, presented with a left scrotal mass and pain. Scrotal ultrasound confirmed a large paratesticular mass, and computed tomography (CT) of the chest, abdomen, and pelvis revealed a bilobed mass in the left scrotal compartment without associated inguinal or abdominopelvic lymphadenopathy, and an indeterminate, subcentimeter, bi-basal subpleural nodules. He underwent a left orchiectomy, and histopathology confirmed the diagnosis of a paratesticular mesothelioma. Postoperatively, the patient had a positron emission tomography (PET) scan showing a new right pleural effusion as well as increasing size of the lobar and pleural nodules bilaterally, all metabolically active and suggestive of progressive metastatic disease. The patient was commenced on ipilimumab and nivolumab immunotherapy, a regimen indicated for malignant pleural mesothelioma; however, the efficacy on paratesticular mesothelioma is not known. After 6&#x2009;months of treatment, the patient demonstrated a partial response to immunotherapy, with a reduction in the size of known pleural nodules and effusion.Literature review suggests that diagnosis requires a high index of suspicion and patients commonly have metastatic disease at the time of diagnosis. Orchiectomy is a common management modality. However, the role, regimen, and benefits of systemic therapy are unclear, warranting further studies investigating management strategies.},
}
@article {pmid37359917,
year = {2023},
author = {Charlaix Hidalgo, AL and Roux, A and Charissoux, A and Mathonnet, M and Descazeaud, A and Durand Fontanier, S and Taibi, A},
title = {First Case of Abdominal and Tunica Vaginalis Multicystic Benign Mesothelioma: Management and Review of Literature.},
journal = {Indian journal of surgical oncology},
volume = {14},
number = {Suppl 1},
pages = {92-96},
pmid = {37359917},
issn = {0975-7651},
abstract = {Multicystic benign mesothelioma is a rare tumor that affects the serosa. Most cases present with peritoneal lesions exclusively. Some identified risk factors are chronic abdominal inflammation, woman of childbearing age, and asbestos exposure. The symptomatology is not specific and can delay the diagnosis. There are no guidelines for the treatment of this pathology. We describe one male patient with abdominal and tunica vaginalis localizations of multicystic benign mesothelioma. The diagnosis was suspected on imaging and confirmed with histological examination. The treatment on an expert center was complete cytoreduction surgery and HIPEC, but the patient had two recurrences during the 2-year of follow-up. This is the first case of simultaneous rare localizations of multicystic benign mesothelioma. No new risk factors were identified. The case underlines the importance of regular examination of all serosa localizations.},
}
@article {pmid37359063,
year = {2023},
author = {Singh, R and Frank, AL},
title = {Analysis of the Indian Government's position on the use of asbestos and its health effects.},
journal = {Public health action},
volume = {13},
number = {2},
pages = {50-52},
pmid = {37359063},
issn = {2220-8372},
abstract = {Based on WHO guidance, all forms of asbestos are a health risk. In India, the mining of asbestos has been stopped, but chrysotile (a type of asbestos) is still imported and processed in large quantities. Chrysotile is mainly used for asbestos-cement roofing, and the manufacturers claim its use to be safe. We sought to understand the Indian Government's position on the use of asbestos. To do so, we have analysed the replies of the executive wing of the Indian Government to questions on asbestos in the Indian Parliament. This revealed that, despite a mining ban, the government has defended the import, processing and continued use of asbestos.},
}
@article {pmid37347449,
year = {2024},
author = {Mejia-Garcia, A and Bonilla, DA and Ramirez, CM and Escobar-Díaz, FA and Combita, AL and Forero, DA and Orozco, C},
title = {Genes and Pathways Involved in the Progression of Malignant Pleural Mesothelioma: A Meta-analysis of Genome-Wide Expression Studies.},
journal = {Biochemical genetics},
volume = {62},
number = {1},
pages = {352-370},
pmid = {37347449},
issn = {1573-4927},
support = {CV2022-CSD-B-12516//Fundaci&#xf3;n Universitaria del Area Andina/ ; },
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/genetics/metabolism ; Phosphatidylinositol 3-Kinases ; *Pleural Neoplasms/genetics/metabolism ; *Lung Neoplasms/pathology ; },
abstract = {Malignant pleural mesothelioma (MPM) is a rare and aggressive neoplasm of the pleural tissue that lines the lungs and is mainly associated with long latency from asbestos exposure. This tumor has no effective therapeutic opportunities nowadays and has a very low five-year survival rate. In this sense, identifying molecular events that trigger the development and progression of this tumor is highly important to establish new and potentially effective treatments. We conducted a meta-analysis of genome-wide expression studies publicly available at the Gene Expression Omnibus (GEO) and ArrayExpress databases. The differentially expressed genes (DEGs) were identified, and we performed functional enrichment analysis and protein-protein interaction networks (PPINs) to gain insight into the biological mechanisms underlying these genes. Additionally, we constructed survival prediction models for selected DEGs and predicted the minimum drug inhibition concentration of anticancer drugs for MPM. In total, 115 MPM tumor transcriptomes and 26 pleural tissue controls were analyzed. We identified 1046 upregulated DEGs in the MPM samples. Cellular signaling categories in tumor samples were associated with the TNF, PI3K-Akt, and AMPK pathways. The inflammatory response, regulation of cell migration, and regulation of angiogenesis were overrepresented biological processes. Expression of SOX17 and TACC1 were associated with reduced survival rates. This meta-analysis identified a list of DEGs in MPM tumors, cancer-related signaling pathways, and biological processes that were overrepresented in MPM samples. Some therapeutic targets to treat MPM are suggested, and the prognostic potential of key genes is shown.},
}
@article {pmid37309879,
year = {2023},
author = {Vimercati, L and Cavone, D and De Maria, L and Caputi, A and Pentimone, F and Sponselli, S and Delvecchio, G and Chellini, E and Binazzi, A and Di Marzio, D and Mensi, C and Consonni, D and Migliore, E and Mirabelli, D and Angelini, A and Martini, A and Negro, C and D'Agostin, F and Grappasonni, I and Pascucci, C and Benfatto, L and Malacarne, D and Casotto, V and Comiati, V and Storchi, C and Mangone, L and Murano, S and Rossin, L and Tallarigo, F and Vitale, F and Verardo, M and Eccher, S and Madeo, G and Staniscia, T and Carrozza, F and Cozzi, I and Romeo, E and Pelullo, P and Labianca, M and Melis, M and Cascone, G and Marinaccio, A and Ferri, GM and Serio, G},
title = {Mesothelioma Risk among Construction Workers According to Job Title: Data from the Italian Mesothelioma Register.},
journal = {La Medicina del lavoro},
volume = {114},
number = {3},
pages = {e2023025},
pmid = {37309879},
issn = {0025-7818},
mesh = {Humans ; *Construction Industry ; *Mesothelioma ; *Mesothelioma, Malignant ; *Occupational Health ; Registries ; },
abstract = {BACKGROUND: An increased risk of mesothelioma has been reported in various countries for construction workers. The Italian National Mesothelioma Registry, from 1993 to 2018, reported exposure exclusively in the construction sector in 2310 cases. We describe the characteristics of these cases according to job title.<br><br>METHODS: We converted into 18 groups the original jobs (N=338) as reported by ISTAT codes ('ATECO 91'). The exposure level was attributed at certain, probable and possible in accordance with the qualitative classification of exposure as reported in the Registry guidelines. Descriptive analysis by jobs highlights the total number of subjects for each single job and certain exposure, in descending order, insulator, plumbing, carpenter, mechanic, bricklayer, electrician, machine operator, plasterer, building contractor, painter and labourer.<br><br>RESULTS: The cases grow for plumbing in the incidence periods 1993-2018, while, as expected, it decreases for insulator. Within each period considered the most numerous cases are always among bricklayers and labourers, these data confirm the prevalence of non-specialised "interchangeable" jobs in Italian construction sector in the past.<br><br>CONCLUSIONS: Despite the 1992 ban, the construction sector still presents an occupational health prevention challenge, circumstances of exposure to asbestos may still occur due to incomplete compliance with prevention and protection measures.},
}
@article {pmid37306905,
year = {2023},
author = {Tamanna, MT and Egbune, C},
title = {Traditional Treatment Approaches and Role of Immunotherapy in Lung Malignancy and Mesothelioma.},
journal = {Cancer treatment and research},
volume = {185},
number = {},
pages = {79-89},
pmid = {37306905},
issn = {0927-3042},
mesh = {Humans ; B7-H1 Antigen ; *Carcinoma, Non-Small-Cell Lung ; Immunotherapy ; *Lung Neoplasms ; *Mesothelioma ; *Mesothelioma, Malignant ; Nivolumab ; Programmed Cell Death 1 Receptor ; Receptors, Death Domain ; },
abstract = {There is no denying that many revolutions took place in the fight against cancer during the last decades. However, cancers have always managed to find new ways to challenge humankinds. Variable genomic epidemiology, socio-economic differences and limitations of widespread screening are the major concerns in cancer diagnosis and early treatment. A multidisciplinary approach is essentially to manage a cancer patient efficiently. Thoracic malignancies including lung cancers and pleural mesothelioma are accountable for little more than 11.6% of the global cancer burden [4]. Mesothelioma is one of the rare cancers, but concern is the incidences are increasing globally. However, the good news is first-line chemotherapy with the combination of immune checkpoints inhibitors (ICIs) in non-small cell lung cancer (NSCLC) and mesothelioma has showed promising respond and improved overall survival (OS) in pivotal clinical trials [10]. ICIs are commonly referred as immunotherapy are antigens on the cancer cells, and inhibitors are the antibodies produce by the T cell defence system. By inhibiting immune checkpoints, the cancer cells become visible to be identified as abnormal cells and attack by the body's defence system [17]. The programmed death receptor-1 (PD-1) and programmed death receptor ligand-1 (PD-L1) inhibitors are commonly used immune checkpoint blockers for anti-cancer treatment. PD-1/PD-L1 are proteins produced by immune cells and mimic by cancer cells that are implicated in inhibiting T cell response to regulate our immune system, which results tumour cells escaping the defence mechanism to achieve immune surveillance. Therefore, inhibiting immune checkpoints as well as monoclonal antibodies can lead to effective apoptosis of tumour cells [17]. Mesothelioma is an industrial disease caused by significant asbestos exposure. It is the cancer of the mesothelial tissue which presents in the lining of the mediastinum of pleura, pericardium and peritoneum, most commonly affected sites are pleura of the lung or chest wall lining [9] as route of asbestos exposure is inhalation. Calretinin is a calcium binding protein, typically over exposed in malignant mesotheliomas and the most useful marker even while initial changes take place [5]. On the other hand, Wilm's tumour 1 (WT-1) gene expression on the tumour cells can be related to prognosis as it can elicit immune response, thereby inhibit cell apoptosis. A systematic review and meta-analysis study conducted by Qi et al. has suggested that expression of WT-1 in a solid tumour is fatal however, it gives the tumour cell a feature of immune sensitivity which then acts positively towards the treatment with immunotherapy. Clinical significance of WT-1 oncogene in treatment is still hugely debatable and needs further attention [21]. Recently, Japan has reinstated Nivolumab in patients with chemo-refractory mesothelioma. According to NCCN guidelines, the salvage therapies include Pembrolizumab in PD-L1 positive patients and Nivolumab alone or with Ipilimumab in cancers irrespective of PD-L1 expression [9]. The checkpoint blockers have taken over the biomarker-based research and demonstrated impressive treatment options in immune sensitive and asbestos-related cancers. It can be expected that in near future the immune checkpoint inhibitors will be considered as approved first-line cancer treatment universally.},
}
@article {pmid37305461,
year = {2023},
author = {Peña-Castro, M and Montero-Acosta, M and Saba, M},
title = {A critical review of asbestos concentrations in water and air, according to exposure sources.},
journal = {Heliyon},
volume = {9},
number = {5},
pages = {e15730},
pmid = {37305461},
issn = {2405-8440},
abstract = {Asbestos, a group of minerals with unique physical and chemical properties, has been widely used in various industries. However, extensive exposure to asbestos fibers, present in the environment, has been linked to several types of cancer, mesothelioma, and asbestosis. Despite worldwide regulations prohibiting or regulating the use of this material, the uncertainty surrounding the concentrations of asbestos fibers in the environment (air and water) from different sources of exposure persists. The objective of this review paper is to identify the levels of asbestos in air and water reported in the literature based on the source of exposure in diverse contexts to assess conformity with the reference limits for this mineral. Initially, the review delineates various forms of exposure and the origin of fiber generation in the environment, whether direct or indirect. Regarding the presence of asbestos in the environment, high concentrations were identified in natural water bodies known as Naturally Occurring Asbestos (NOA), and there is a risk in the process of distributing drinking water due to the presence of asbestos-cement pipes. In the air, studies to determine asbestos concentrations vary based on the sources of exposure in each region or city studied. The presence of asbestos mines around the city and the intensity of vehicular traffic are some of the most relevant sources found to be related to high concentrations of asbestos fibers in the air. The present review paper features a critical review section in each chapter to highlight critical points found in the literature and suggest new methodologies/ideas to standardize future research. It emphasizes the necessity to standardize methods for measuring asbestos concentrations in air and water arising from diverse sources of exposure to enable comparisons between different regions and countries.},
}
@article {pmid37302119,
year = {2023},
author = {Torén, K and Neitzel, RL and Eriksson, HP and Andersson, E},
title = {Cancer incidence among workers in soft paper mills: A cohort study.},
journal = {American journal of industrial medicine},
volume = {66},
number = {9},
pages = {728-735},
doi = {10.1002/ajim.23508},
pmid = {37302119},
issn = {1097-0274},
mesh = {Male ; Humans ; Female ; Cohort Studies ; Incidence ; *Occupational Diseases/epidemiology/etiology ; *Neoplasms/chemically induced/epidemiology ; *Mesothelioma/epidemiology ; *Mesothelioma, Malignant ; *Pleural Neoplasms ; *Occupational Exposure/adverse effects ; *Sarcoma/complications ; Dust ; },
abstract = {OBJECTIVES: To elucidate whether occupational exposure to soft paper dust increases the incidence of cancer.<br><br>METHODS: We studied 7988 workers in Swedish soft paper mills from 1960 to 2008, of whom 3233 (2 187 men and 1046 women) had more than 10 years of employment. They were divided into high exposure (>5&#x2009;mg/m[3] for >1 year) or lower exposure to soft paper dust based on a validated job-exposure matrix. They were followed from 1960 to 2019, and person-years at risk were stratified according to gender, age, and calendar-year. The expected numbers of incident tumors were calculated using the Swedish population as the reference, and standardized incidence ratios (SIR) with 95% confidence intervals (95% CI) were assessed.<br><br>RESULTS: Among high-exposure workers with more than 10 years of employment, there was an increased incidence of colon cancer (SIR 1.66, 95% CI 1.20-2.31), small intestine cancer (SIR 3.27, 95% CI 1.36-7.86), and thyroid gland cancer (SIR 2.68, 95% CI 1.11-6.43), as well as lung cancer (SIR 1.56, 95% CI 1.12-2.19). Among the lower-exposed workers there was an increased incidence of connective tissue tumors (sarcomas) (SIR 2.26, 95% CI 1.13-4.51) and pleural mesothelioma (SIR 3.29, 95% CI 1.37-7.91).<br><br>CONCLUSION: Workers in soft paper mills with high exposure to soft paper dust have an increased incidence of large and small intestine tumors. Whether the increased risk is caused by paper dust exposure or some unknown associated factors is unclear. The increased incidence of pleural mesothelioma is probably linked to asbestos exposure. The reason for increased incidence of sarcomas is unknown.},
}
@article {pmid37297561,
year = {2023},
author = {Fazzo, L and Minelli, G and De Santis, M and Ceccarelli, E and Iavarone, I and Zona, A},
title = {The Epidemiological Surveillance of Mesothelioma Mortality in Italy as a Tool for the Prevention of Asbestos Exposure.},
journal = {International journal of environmental research and public health},
volume = {20},
number = {11},
pages = {},
pmid = {37297561},
issn = {1660-4601},
mesh = {Male ; Female ; Humans ; *Mesothelioma, Malignant ; *Mesothelioma/epidemiology ; *Asbestos ; Italy/epidemiology ; Asbestos, Amphibole ; *Occupational Exposure ; },
abstract = {As part of a surveillance plan active since the early 1990s, this study evaluates malignant mesothelioma (MM) mortality for the time-window 2010-2019 in Italy, a country that banned asbestos in 1992. National and regional mortality rates for MM, and municipal standardized mortality ratios (all mesotheliomas, pleural (MPM) and peritoneal (MPeM)), by gender and age group were calculated. A municipal clustering analysis was also performed. There were 15,446 deaths from MM (11,161 males, 3.8 × 100,000; 4285 females, 1.1 × 100,000), of which 12,496 were MPM and 661 were MPeM. In the study period, 266 people ≤50 years died from MM. A slightly decreasing rate among males since 2014 was observed. The areas at major risk hosted asbestos-cement plants, asbestos mines (chrysotile in Balangero), shipyards, petrochemical and chemical plants, and refineries. Female mortality excesses particularly were found in municipalities with a fluoro-edenite-contaminated mine (Biancavilla) and textile facilities. Excesses were also found in a region with the presence of natural asbestos fibres and in males living in two small islands. The Italian National Prevention Plan stated recommendations to eliminate asbestos exposures and to implement health surveillance and healthcare for people exposed to asbestos.},
}
@article {pmid37296902,
year = {2023},
author = {Rondon, L and Fu, R and Patel, MR},
title = {Success of Checkpoint Blockade Paves the Way for Novel Immune Therapy in Malignant Pleural Mesothelioma.},
journal = {Cancers},
volume = {15},
number = {11},
pages = {},
pmid = {37296902},
issn = {2072-6694},
abstract = {Malignant pleural mesothelioma (MPM) is a malignancy associated with asbestos exposure and is typically categorized as an orphan disease. Recent developments in immunotherapy with anti-PD-1 and anti-CTLA-4 antibodies, specifically with agents nivolumab and ipilimumab, have demonstrated an improvement in overall survival over the previous standard chemotherapy leading to their FDA-approval as first-line therapy for unresectable disease. For quite some time, it has been known that these proteins are not the only ones that function as immune checkpoints in human biology, and the hypothesis that MPM is an immunogenic disease has led to an expanding number of studies investigating alternative checkpoint inhibitors and novel immunotherapy for this malignancy. Early trials are also supporting the notion that therapies that target biological molecules on T cells, cancer cells, or that trigger the antitumor activity of other immune cells may represent the future of MPM treatment. Moreover, mesothelin-targeted therapies are thriving in the field, with forthcoming results from multiple trials signaling an improvement in overall survival when combined with other immunotherapy agents. The following manuscript will review the current state of immune therapy for MPM, explore the knowledge gaps in the field, and discuss ongoing novel immunotherapeutic research in early clinical trials.},
}
@article {pmid37295554,
year = {2023},
author = {Schaefer, IM and Mariño-Enríquez, A and Hammer, MM and Padera, RF and Sholl, LM},
title = {Recurrent Tumor Suppressor Alterations in Primary Pericardial Mesothelioma.},
journal = {Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
volume = {36},
number = {9},
pages = {100237},
pmid = {37295554},
issn = {1530-0285},
support = {K08 CA241085/CA/NCI NIH HHS/United States ; },
mesh = {Humans ; Male ; Female ; Aged ; *Lung Neoplasms/pathology ; Neoplasm Recurrence, Local ; *Mesothelioma, Malignant ; *Mesothelioma/diagnosis ; *Pleural Neoplasms/pathology ; *Heart Neoplasms/genetics ; *Thymus Neoplasms ; Ubiquitin Thiolesterase/genetics/metabolism ; Biomarkers, Tumor/genetics/metabolism ; },
abstract = {Primary pericardial mesotheliomas are extremely rare, accounting for <1% of all mesotheliomas, and their molecular genetic features and predisposing factors remain to be determined. Here, we report the clinicopathologic, immunohistochemical, and molecular genetic findings of 3 pericardial mesotheliomas without pleural involvement. Three cases diagnosed between 2004 and 2022 were included in the study and analyzed by immunohistochemistry and targeted next-generation sequencing (NGS); corresponding nonneoplastic tissue was sequenced in all cases. Two patients were female and 1 was male, aged between 66 and 75 years. Two patients each had prior asbestos exposure and were smokers. Histologic subtypes were epithelioid in 2 cases and biphasic in 1 case. Immunohistochemical staining identified expression of cytokeratin AE1/AE3 and calretinin in all cases, D2-40 in 2 cases, and WT1 in 1 case. Staining for tumor suppressors revealed loss of p16, MTAP, and Merlin (NF2) expression in 2 cases and loss of BAP1 and p53 in 1 case. Abnormal cytoplasmic BAP1 expression was observed in an additional case. Protein expression abnormalities correlated with NGS results, which showed concurrent complete genomic inactivation of CDKN2A/p16, CDKN2B, MTAP, and NF2 in 2 mesotheliomas and of BAP1 and TP53 in 1 mesothelioma each, respectively. In addition, 1 patient harbored a pathogenic BRCA1 germline mutation, which resulted in biallelic inactivation in the mesothelioma. All mesotheliomas were mismatch repair proficient and showed several chromosomal gains and losses. All patients died from disease. Our study demonstrates that pericardial mesotheliomas share common morphologic, immunohistochemical, and molecular genetic features with pleural mesothelioma, including recurrent genomic inactivation of canonical tumor suppressors. Our study adds new insights into the genetic landscape of primary pericardial mesothelioma and highlights BRCA1 loss as a potential contributing factor in a subset of cases, thereby contributing to refined precision diagnostics for this rare cancer.},
}
@article {pmid37293522,
year = {2023},
author = {Tagliaferri, AR and Melki, G and Rezkalla, A and Baddoura, W},
title = {Diffuse malignant peritoneal mesothelioma presenting as small bowel obstruction.},
journal = {Radiology case reports},
volume = {18},
number = {8},
pages = {2681-2684},
pmid = {37293522},
issn = {1930-0433},
abstract = {Mesotheliomas are aggressive malignant tumors which can occur most commonly in the pleural space, however can occur in the peritoneum in those with an extensive history of asbestos exposure. Primary peritoneal mesothelioma is relatively rare and is a fatal diagnosis. The prognosis of primary peritoneal mesothelioma is very poor and individuals are at high risk of developing mesothelioma in another cavity within the first year after initial diagnosis. Herein, we present a case of primary peritoneal mesothelioma, presenting as small bowel obstruction.},
}
@article {pmid37292347,
year = {2023},
author = {Migliore, M and Fiore, M and Filippini, T and Tumino, R and Sabbioni, M and Spatola, C and Polosa, R and Vigneri, P and Nardini, M and Castorina, S and Basile, F and Ferrante, M and , },
title = {Comparison of video-assisted pleurectomy/decortication surgery plus hyperthermic intrathoracic chemotherapy with VATS talc pleurodesis for the treatment of malignant pleural mesothelioma: A pilot study.},
journal = {Heliyon},
volume = {9},
number = {6},
pages = {e16685},
pmid = {37292347},
issn = {2405-8440},
abstract = {Hyperthermic intrathoracic chemotherapy (HITHOC) adjunct to surgery for Malignant Pleural Mesothelioma (MPM) has no definite role. The primary objective of this pilot-trial was to evaluate the feasibility for future large studies. The study design was a prospective randomized three-centric pilot trial. We recruited patients diagnosed with MPM and prospectively assigned them to two groups: Group A: Video Assisted Thoracic Surgery (VATS) talc pleurodesis or Group B: Video-assisted P/D plus HITHOC. From November-2011 to July-2017 24 males and 3 females, with a median age of 68-years were enrolled (recruitment rate 5 patients/year). Preoperative stage was I-II, and 18 had epithelioid type. 14 patients were in the Group A. Operative mortality was 0. Follow-up ranged 6-80 months. The median overall survival time started to diverge at 20 months, being 19 months (95% CI 12-25) in Group A and 28 months (95% CI 0-56) in Group B. Survival rate for the epithelioid type was 15 months (95% CI 0-34) in Group A and 45 months (95% CI 0-107) in the Group B. These findings suggest that video-assisted P/D plus HITHOC may improve survival time in MPM patients undergoing surgical treatment and support the need for a larger multicenter randomized clinical trial.},
}
@article {pmid37254056,
year = {2023},
author = {Ito, F and Kato, K and Yanatori, I and Maeda, Y and Murohara, T and Toyokuni, S},
title = {Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1.},
journal = {BMC cancer},
volume = {23},
number = {1},
pages = {487},
pmid = {37254056},
issn = {1471-2407},
support = {JP18J13646, JP20K22805 and JP21K15484//Japan Society for the Promotion of Science/ ; JP20K17145, JP22K08123//Japan Society for the Promotion of Science/ ; JP19H05462 and JP20H05502//Japan Society for the Promotion of Science/ ; JPMJCR19H4//Core Research for Evolutional Science and Technology/ ; 19-25126//Princess Takamatsu Cancer Research Fund/ ; },
mesh = {Animals ; Humans ; Mice ; *Cisplatin/pharmacology ; Collagen/metabolism ; *Mesothelioma, Malignant/metabolism ; Organoids/pathology ; *Copper Transporter 1/metabolism ; },
abstract = {Organoids are a three-dimensional (3D) culture system that simulate actual organs. Therefore, tumor organoids are expected to predict precise response to chemotherapy in patients. However, to date, few studies have studied the drug responses in organoids of malignant mesothelioma (MM). The poor prognosis of MM emphasizes the importance of establishing a protocol for generating MM-organoid for research and clinical use. Here, we established murine MM organoids from p53[+/-] or wild-type C57BL/6 strain by intraperitoneal injection either with crocidolite or carbon nanotube. Established MM-organoids proliferated in Matrigel as spheroids. Subcutaneous injection assays revealed that the MM-organoids mimicked actual tissue architecture and maintained the original histological features of the primary MM. RNA sequencing and pathway analyses revealed that the significant expressional differences between the 2D- and 3D-culture systems were observed in receptor tyrosine kinases, including IGF1R and EGFR, glycosylation and cholesterol/steroid metabolism. MM-organoids exhibited a more sensitive response to cisplatin through stable plasma membrane localization of a major cisplatin transporter, copper transporter 1/Slc31A1 (Ctr1) in comparison to 2D-cultures, presumably through glycosylation and lipidation. The Matrigel culture system facilitated the localization of CTR1 on the plasma membrane, which simulated the original MMs and the subcutaneous xenografts. These results suggest that the newly developed protocol for MM-organoids is useful to study strategies to overcome chemotherapy resistance to cisplatin.},
}
@article {pmid37253383,
year = {2023},
author = {Nash, A and Firth Née Phan, T and Creaney, J},
title = {New Markers for Management of Mesothelioma.},
journal = {Seminars in respiratory and critical care medicine},
volume = {44},
number = {4},
pages = {491-501},
doi = {10.1055/s-0043-1769097},
pmid = {37253383},
issn = {1098-9048},
mesh = {Humans ; *Mesothelioma, Malignant ; *Lung Neoplasms/diagnosis/drug therapy/genetics ; *Mesothelioma/diagnosis/therapy ; *Pleural Neoplasms/diagnosis/drug therapy ; Biomarkers, Tumor/genetics ; },
abstract = {In this review, we provide an update on the status of cancer biomarkers for the clinical management of pleural mesothelioma, an aggressive cancer associated with asbestos exposure. Mesothelioma can be difficult to diagnose, and response to treatment is transient, even with recently adopted immune checkpoint inhibitor (ICI) combinations. Identification of mesothelioma-specific biomarkers could facilitate early diagnosis and tailor treatment strategies. Mesothelioma is characterized by frequent loss or alteration of the tumor suppressor genes cyclin-dependent kinase inhibitor 2A (CDKN2A) and BRCA1-associated protein-1 (BAP1). Accumulating data show these genes and/or their related protein products will be valuable tissue-based biomarkers for mesothelioma. Loss of BAP1, CDKN2A, p16, or methylthioadenosine phosphorylase provide pathologists with a reliable means of differentiating between mesothelioma and reactive mesothelial cell proliferations. This can aid diagnosis in difficult cases and is requisite for the identification of the new pathological entity malignant mesothelioma in situ. However, limited progress in identifying clinically useful soluble biomarkers in this cancer type has been made, with mesothelin remaining the benchmark. To date, results from studies to identify predictive biomarkers for ICI response have been disappointing. A recent retrospective study demonstrated BAP1 loss was predictive of improved survival following combination pemetrexed- and platinum-based chemotherapy. Validation of this result could have important clinical implications. Clinical trials aimed at targeting therapy based on biomarker expression are generally in the early phase setting, with overall results being moderate. The identification of biomarkers for mesothelioma remains a key research question due to their potential to improve patient outcomes in this deadly cancer.},
}
@article {pmid37248188,
year = {2023},
author = {Zhao, F and Zhang, YL and Liu, X and Chen, TH and Li, J},
title = {[A case of malignant peritoneal mesothelioma].},
journal = {Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases},
volume = {41},
number = {4},
pages = {307-309},
doi = {10.3760/cma.j.cn121094-20220328-00158},
pmid = {37248188},
issn = {1001-9391},
mesh = {Humans ; *Mesothelioma, Malignant/drug therapy ; *Mesothelioma/diagnosis ; Pemetrexed/therapeutic use ; Cisplatin/therapeutic use ; *Peritoneal Neoplasms/diagnosis ; *Pleural Neoplasms ; *Lung Neoplasms/drug therapy ; },
abstract = {Malignant mesothelioma is a highly malignant disease that most often occurs in the pleural cavity, followed by the peritoneum and pericardium. Malignant peritoneal mesothelioma (MPM) accounts for 10%-15% of all mesothelioma. The most important risk factor for MPM is exposure to asbestos. MPM has no specific clinical symptoms, imaging and histopathology are critical for the diagnosis. There are currently no generally accepted guidelines for curative treatment of MPM. The patient mainly presented with abdominal pain, abdominal distension and discomfort. Due to extensive omentum metastasis, no further surgical treatment was performed. Pemetrexed combined with cisplatin chemotherapy was given for 2 cycles, and the patient is still alive.},
}
@article {pmid37247334,
year = {2023},
author = {Ntlailane, L and Sebola, L and Singo, D and Nthoke, T and Mizan, G},
title = {Managing the risks of an asbestos bulk storage facility at a research institute.},
journal = {Annals of work exposures and health},
volume = {67},
number = {7},
pages = {907-911},
doi = {10.1093/annweh/wxad028},
pmid = {37247334},
issn = {2398-7316},
mesh = {Humans ; *Mesothelioma ; *Occupational Exposure ; *Asbestos ; Asbestos, Crocidolite ; Academies and Institutes ; },
abstract = {The South African National Institute for Occupational Health (NIOH), formerly the Pneumoconiosis Research Unit, has previously milled about 544 kg of anthophyllite, crocidolite, amosite and chrysotile asbestos fibre materials. This endeavour came about in an attempt to address a recommendation, made by the International Union Against Cancer (UICC), to make asbestos standard reference samples available for research. Some of these reference samples, as well as the bulk, unprocessed materials are still within the care of the NIOH and can be obtained for the purpose of Public Health research under strict terms and conditions. Considering the hazardous nature of asbestos and regulated prohibitions imposed on this mineral, the NIOH asbestos storage facility is being subjected to various occupational and environmental control measures to ensure that any potential fibre release, and subsequent risk of exposure, are prevented.},
}
@article {pmid37232345,
year = {2023},
author = {Broggi, G and Filetti, V and Magro, G and Morante, B and Garro, R and Ledda, C and Rapisarda, V and Lombardo, C and Loreto, C and Caltabiano, R},
title = {Immunohistochemical expression of cAMP in fluoroedenite‑induced malignant pleural mesothelioma: Preliminary results.},
journal = {Molecular medicine reports},
volume = {28},
number = {1},
pages = {},
doi = {10.3892/mmr.2023.13019},
pmid = {37232345},
issn = {1791-3004},
mesh = {Male ; Female ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; *Mesothelioma, Malignant ; *Mesothelioma/chemically induced/metabolism ; *Lung Neoplasms/pathology ; *Asbestos ; },
abstract = {Despite advances in understanding of the biology of malignant pleural mesothelioma (MPM), the prognosis of this malignancy remains poor. Although asbestos still remains the main pathogenic agent of MPM, other asbestos‑like fibers such as fluoro‑edenite (FE) fibers, induce MPM. Notable incidence and mortality rates of MPM have been found in Biancavilla, Italy, where FE fibers have been extracted from building materials for >50 years. Cyclic adenosine monophosphate (cAMP) is a secondary messenger that plays a key role in several physiological and pathological mechanisms regulating protein kinase A (PKA) and the CREB pathway. Hyperactivation of the cAMP/PKA/CREB pathway is involved in many neoplastic processes, including tumor cell proliferation, invasion and metastatic spread. The present study investigated immunohistochemical expression of cAMP in patients with FE‑induced MPM, which included six males and four females with an age range of 50‑93 years. There was high immunoexpression of cAMP in 5 out of 10 tumors while the remaining 5 cases showed low immunoexpression. In addition, there was a correlation between cAMP overexpression and decreased survival times (mean overall survival times, 7.5 months in high expression group vs. 18 months in low expression group).},
}
@article {pmid37220527,
year = {2023},
author = {Wang, D and Zhu, J and Li, N and Lu, H and Gao, Y and Zhuang, L and Chen, Z and Mao, W},
title = {GC-MS-based untargeted metabolic profiling of malignant mesothelioma plasma.},
journal = {PeerJ},
volume = {11},
number = {},
pages = {e15302},
pmid = {37220527},
issn = {2167-8359},
mesh = {Humans ; *Mesothelioma, Malignant ; Gas Chromatography-Mass Spectrometry ; Metabolomics ; Alanine ; },
abstract = {BACKGROUND: Malignant mesothelioma (MM) is a cancer caused mainly by asbestos exposure, and is aggressive and incurable. This study aimed to identify differential metabolites and metabolic pathways involved in the pathogenesis and diagnosis of malignant mesothelioma.<br><br>METHODS: By using gas chromatography-mass spectrometry (GC-MS), this study examined the plasma metabolic profile of human malignant mesothelioma. We performed univariate and multivariate analyses and pathway analyses to identify differential metabolites, enriched metabolism pathways, and potential metabolic targets. The area under the receiver-operating curve (AUC) criterion was used to identify possible plasma biomarkers.<br><br>RESULTS: Using samples from MM (n = 19) and healthy control (n = 22) participants, 20 metabolites were annotated. Seven metabolic pathways were disrupted, involving alanine, aspartate, and glutamate metabolism; glyoxylate and dicarboxylate metabolism; arginine and proline metabolism; butanoate and histidine metabolism; beta-alanine metabolism; and pentose phosphate metabolic pathway. The AUC was used to identify potential plasma biomarkers. Using a threshold of AUC = 0.9, five metabolites were identified, including xanthurenic acid, (s)-3,4-hydroxybutyric acid, D-arabinose, gluconic acid, and beta-d-glucopyranuronic acid.<br><br>CONCLUSIONS: To the best of our knowledge, this is the first report of a plasma metabolomics analysis using GC-MS analyses of Asian MM patients. Our identification of these metabolic abnormalities is critical for identifying plasma biomarkers in patients with MM. However, additional research using a larger population is needed to validate our findings.},
}
@article {pmid37220304,
year = {2023},
author = {Korchevskiy, AA and Wylie, AG},
title = {Toxicological and epidemiological approaches to carcinogenic potency modeling for mixed mineral fiber exposure: the case of fibrous balangeroite and chrysotile.},
journal = {Inhalation toxicology},
volume = {35},
number = {7-8},
pages = {185-200},
doi = {10.1080/08958378.2023.2213720},
pmid = {37220304},
issn = {1091-7691},
mesh = {Humans ; Asbestos, Serpentine/toxicity ; Mineral Fibers/toxicity ; Carcinogens/toxicity ; Asbestos, Amphibole/toxicity ; *Mesothelioma/chemically induced/epidemiology ; *Mesothelioma, Malignant ; *Lung Neoplasms/chemically induced/epidemiology ; *Asbestos/analysis ; },
abstract = {CONTEXT: Excess mesothelioma risk was observed among chrysotile miners and millers in Balangero, Italy. The mineral balangeroite has been identified in an asbestiform habit from the Balangero chrysotile mine (Italy). Previous studies did not contain a detailed description of the fiber dimensions, thus limiting possible approaches to estimating their carcinogenic potential.<br><br>OBJECTIVES: To reconstruct excess mesothelioma risk based on characteristics of mixed fiber exposure.<br><br>METHODS: The lengths and widths of particles from a sample of balangeroite were measured by transmission electron microscopy (TEM). Statistical analysis and modeling were applied to assess the toxicological potential of balangeroite.<br><br>RESULTS: Balangeroite fibers are characterized as asbestiform, with geometric mean length of 10 &#x3bc;m, width of 0.54 &#x3bc;m, aspect ratio of 19, and specific surface area of 13.8 (1/&#x3bc;m). Proximity analysis shows dimensional characteristics of balangeroite close to asbestiform anthophyllite. Modeling estimates the average potency of balangeroite as 0.04% (95% CI 0.0058, 0.16) based on dimensional characteristics and 0.05% (95% CI-0.04, 0.24) based on epidemiological data. The available estimate of the fraction of balangeroite in the Balangero mine is very approximate. There were no data for airborne balangeroite fibers from the Balangero mine and no lung burden data are available. All estimates were performed using weight fractions of balangeroite and chrysotile. However, based on reasonable assumptions, of the seven cases of mesothelioma in the cohort, about three cases (43%) can be attributed to fibrous balangeroite.<br><br>CONCLUSION: The presence of different types of mineral fibers in aerosolized materials even in small proportions can explain observed cancer risks.},
}
@article {pmid37217834,
year = {2023},
author = {Zambrano, E and Matoso, A and Reyes-Múgica, M},
title = {Mesotheliomas in Children.},
journal = {Advances in anatomic pathology},
volume = {30},
number = {4},
pages = {275-279},
doi = {10.1097/PAP.0000000000000403},
pmid = {37217834},
issn = {1533-4031},
mesh = {Adult ; Humans ; Child ; *Mesothelioma/genetics/pathology ; *Asbestos ; },
abstract = {Mesotheliomas are rare and aggressive tumors that originate from mesothelial cells. Although exceedingly rare, these tumors may occur in children. Different from adult mesotheliomas, however, environmental exposures particularly to asbestos do not appear to play a major role in mesotheliomas in children, in whom specific genetic rearrangements driving these tumors have been identified in recent years. These molecular alterations may increasingly offer opportunities for targeted therapies in the future, which may provide better outcomes for these highly aggressive malignant neoplasms.},
}
@article {pmid37210180,
year = {2023},
author = {Carbone, M and Yang, H and Pass, HI and Taioli, E},
title = {Did the Ban on Asbestos Reduce the Incidence of Mesothelioma?.},
journal = {Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
volume = {18},
number = {6},
pages = {694-697},
doi = {10.1016/j.jtho.2023.03.013},
pmid = {37210180},
issn = {1556-1380},
support = {R01 ES030948/ES/NIEHS NIH HHS/United States ; R01 CA237235/CA/NCI NIH HHS/United States ; R01 CA198138/CA/NCI NIH HHS/United States ; U01 CA214195/CA/NCI NIH HHS/United States ; },
mesh = {Humans ; Incidence ; *Lung Neoplasms/epidemiology/prevention &amp; control/complications ; *Mesothelioma/epidemiology/prevention &amp; control/etiology ; *Mesothelioma, Malignant ; *Asbestos/adverse effects ; *Occupational Exposure/adverse effects/prevention &amp; control ; },
}
@article {pmid37199503,
year = {2023},
author = {Giacobbe, C and Moliterni, A and Di Giuseppe, D and Malferrari, D and Wright, JP and Mattioli, M and Raneri, S and Giannini, C and Fornasini, L and Mugnaioli, E and Ballirano, P and Gualtieri, AF},
title = {The crystal structure of the killer fibre erionite from Tuzköy (Cappadocia, Turkey).},
journal = {IUCrJ},
volume = {10},
number = {Pt 4},
pages = {397-410},
pmid = {37199503},
issn = {2052-2525},
support = {20173X8WA4//PRIN: Progetti di Ricerca di Rilevante Interesse Nazionale-Bando 2017-Prot/ ; },
abstract = {Erionite is a non-asbestos fibrous zeolite classified by the International Agency for Research on Cancer (IARC) as a Group 1 carcinogen and is considered today similar to or even more carcinogenic than the six regulated asbestos minerals. Exposure to fibrous erionite has been unequivocally linked to cases of malignant mesothelioma (MM) and this killer fibre is assumed to be directly responsible for more than 50% of all deaths in the population of the villages of Karain and Tuzköy in central Anatolia (Turkey). Erionite usually occurs in bundles of thin fibres and very rarely as single acicular or needle-like fibres. For this reason, a crystal structure of this fibre has not been attempted to date although an accurate characterization of its crystal structure is of paramount importance for our understanding of the toxicity and carcinogenicity. In this work, we report on a combined approach of microscopic (SEM, TEM, electron diffraction), spectroscopic (micro-Raman) and chemical techniques with synchrotron nano-single-crystal diffraction that allowed us to obtain the first reliable ab initio crystal structure of this killer zeolite. The refined structure showed regular T-O distances (in the range 1.61-1.65 Å) and extra-framework content in line with the chemical formula (K2.63Ca1.57Mg0.76Na0.13Ba0.01)[Si28.62Al7.35]O72·28.3H2O. The synchrotron nano-diffraction data combined with three-dimensional electron diffraction (3DED) allowed us to unequivocally rule out the presence of offretite. These results are of paramount importance for understanding the mechanisms by which erionite induces toxic damage and for confirming the physical similarities with asbestos fibres.},
}
@article {pmid37194050,
year = {2023},
author = {RanYue, W and ChunYan, W and Likun, H and LiPing, Z and JieLu, L and ZhengWei, D},
title = {Diffuse intrapulmonary mesothelioma mimicking pulmonary lepidic adenocarcinoma: a rare case report and review of the literature.},
journal = {Diagnostic pathology},
volume = {18},
number = {1},
pages = {64},
pmid = {37194050},
issn = {1746-1596},
mesh = {Humans ; In Situ Hybridization, Fluorescence ; *Mesothelioma/diagnosis/pathology ; *Mesothelioma, Malignant/diagnosis ; *Lung Neoplasms/diagnosis/pathology ; *Pleural Neoplasms/pathology ; *Adenocarcinoma of Lung/diagnosis ; *Lung Diseases, Interstitial/diagnosis ; Biomarkers, Tumor/metabolism ; Diagnosis, Differential ; },
abstract = {Mesothelioma, with various clinical manifestations, radiological features, and histomorphological types, can be divided into epithelioid, sarcomatoid, and biphasic types, according to their histomorphological characteristics. There is a rare growth pattern of pleural mesothelioma: diffuse intrapulmonary mesothelioma (DIM), with a distinctive pattern of predominantly intrapulmonary growth, has no or minimal pleural involvement, and simulates interstitial lung disease(ILD) clinically and radiologically. A 59-year-old man presented to the hospital with recurrent pleural effusions for 4 years and a history of asbestos exposure. Computed tomography (CT) showed bilateral pure ground-glass opacity lesions, and the tumor cells showed a lepidic growth pattern pathologically. Immunohistochemical staining was positive for CK, WT-1, calretinin, D2-40, CK5/6, and Claudin4, while TTF-1, CEA, EMA, CK7, CK20, and other epithelial markers were negative. BAP1 loss its expression, and MTAP was positive in cytoplasm. CDKN2A was negative tested by Fluorescence in situ hybridization (FISH). The final diagnosis was DIM. In conclusion, we should recognize this rare disease to avoid misdiagnosis and delayed treatment.},
}
@article {pmid37190292,
year = {2023},
author = {Ahmadzada, T and Vijayan, A and Vafaee, F and Azimi, A and Reid, G and Clarke, S and Kao, S and Grau, GE and Hosseini-Beheshti, E},
title = {Small and Large Extracellular Vesicles Derived from Pleural Mesothelioma Cell Lines Offer Biomarker Potential.},
journal = {Cancers},
volume = {15},
number = {8},
pages = {},
pmid = {37190292},
issn = {2072-6694},
support = {Corporate/private financial support//Turner Freeman Lawyers/ ; TBC//Dust Diseases Board/ ; },
abstract = {Pleural mesothelioma, previously known as malignant pleural mesothelioma, is an aggressive and fatal cancer of the pleura, with one of the poorest survival rates. Pleural mesothelioma is in urgent clinical need for biomarkers to aid early diagnosis, improve prognostication, and stratify patients for treatment. Extracellular vesicles (EVs) have great potential as biomarkers; however, there are limited studies to date on their role in pleural mesothelioma. We conducted a comprehensive proteomic analysis on different EV populations derived from five pleural mesothelioma cell lines and an immortalized control cell line. We characterized three subtypes of EVs (10 K, 18 K, and 100 K), and identified a total of 4054 unique proteins. Major differences were found in the cargo between the three EV subtypes. We show that 10 K EVs were enriched in mitochondrial components and metabolic processes, while 18 K and 100 K EVs were enriched in endoplasmic reticulum stress. We found 46 new cancer-associated proteins for pleural mesothelioma, and the presence of mesothelin and PD-L1/PD-L2 enriched in 100 K and 10 K EV, respectively. We demonstrate that different EV populations derived from pleural mesothelioma cells have unique cancer-specific proteomes and carry oncogenic cargo, which could offer a novel means to extract biomarkers of interest for pleural mesothelioma from liquid biopsies.},
}
@article {pmid37190163,
year = {2023},
author = {Collatuzzo, G and Turati, F and Malvezzi, M and Negri, E and La Vecchia, C and Boffetta, P},
title = {Attributable Fraction of Cancer Related to Occupational Exposure in Italy.},
journal = {Cancers},
volume = {15},
number = {8},
pages = {},
pmid = {37190163},
issn = {2072-6694},
support = {22987//Italian Association for Cancer Research/ ; },
abstract = {BACKGROUND: Exposure to occupational carcinogens is an important and avoidable cause of cancer. We aimed to provide an evidence-based estimate of the burden of occupation-related cancers in Italy.<br><br>METHODS: The attributable fraction (AF) was calculated based on the counterfactual scenario of no occupational exposure to carcinogens. We included exposures classified as IARC group 1 and with reliable evidence of exposure in Italy. Relative risk estimates for selected cancers and prevalences of exposure were derived from large-scale studies. Except for mesothelioma, a 15-20-year latency period between exposure and cancer was considered. The data on cancer incidence in 2020 and mortality in 2017 in Italy were obtained from the Italian Association of Cancer Registries.<br><br>RESULTS: The most prevalent exposures were UV radiation (5.8%), diesel exhaust (4.3%), wood dust (2.3%) and silica dust (2.1%). Mesothelioma had the largest AF to occupational carcinogens (86.6%), followed by sinonasal cancer (11.8%) and lung cancer (3.8%). We estimated that 0.9% of cancer cases (N~3500) and 1.6% of cancer deaths (N~2800) were attributable to occupational carcinogens in Italy. Of these, about 60% were attributable to asbestos, 17.5% to diesel exhaust, followed by chromium and silica dust (7% and 5%).<br><br>CONCLUSIONS: Our estimates provide up-to-date quantification of the low, but persistent, burden of occupational cancers in Italy.},
}
@article {pmid37189132,
year = {2023},
author = {Kauschke, V and Philipp-Gehlhaar, M and Schneider, J},
title = {Expression of microRNAs in leukocytes and serum of asbestosis patients.},
journal = {European journal of medical research},
volume = {28},
number = {1},
pages = {175},
pmid = {37189132},
issn = {2047-783X},
mesh = {Humans ; *MicroRNAs ; *Asbestosis/genetics ; Biomarkers ; *Asbestos ; Leukocytes/metabolism ; },
abstract = {BACKGROUND: Although asbestos use is banned in many countries, long latency of asbestos-related diseases like pleural plaques or asbestosis mean it is still a public health issue. People suffering from these diseases have a higher risk of developing mesothelioma or lung cancer, which can progress quickly and aggressively. MicroRNAs were suggested as potential biomarkers in several diseases. However, in asbestosis, blood microRNAs are less explored. Since miR-32-5p, miR-143-3p, miR-145-5p, miR-146b-5p, miR-204-5p and miR-451a are involved in fibrotic processes and in cancer, expression of these microRNAs was analyzed in leukocytes and serum of asbestosis patients.<br><br>METHODS: MicroRNA expression was analyzed in leukocytes and serum of 36 patients (26 affected by pleural plaques and 10 by asbestosis) and 15 healthy controls by real-time RT-PCR. Additionally, data analyses were performed regarding disease severity based on ILO classification.<br><br>RESULTS: MicroRNA miR-146b-5p was significantly down-regulated in leukocytes of patients suffering from pleural plaques with a large effect indicated by &#x3b7;[2]p&#x2009;=&#x2009;0.150 and Cohen's f&#x2009;=&#x2009;0.42, a value of difference of 0.725 and a 95% confidence interval of 0.070-1.381. In patients suffering from asbestosis miR-146b-5p was not significantly regulated. However, data analyses considering disease severity only, revealed that miR-146b-5p was significantly down-regulated in leukocytes of mildly diseased patients compared to controls with a large effect indicated by &#x3b7;[2]p&#x2009;=&#x2009;0.178 and Cohen's f&#x2009;=&#x2009;0.465, a value of difference of 0.848 and a 95% confidence interval of 0.097-1.599. Receiver operating characteristic (ROC) curve and an area under the ROC curve value of 0.757 for miR-146b-5p indicated acceptable discrimination ability between patients suffering from pleural plaques and healthy controls. Less microRNAs were detectable in serum than in leukocytes, showing no significant expression differences in all participants of this study. Moreover, miR-145-5p was regulated significantly differently in leukocytes and serum. An R[2] value of 0.004 for miR-145-5p indicated no correlation in microRNA expression between leukocytes and serum.<br><br>CONCLUSION: Leukocytes seem more suitable than serum for microRNA analyses regarding disease and potentially cancer risk assessment of patients suffering from asbestos-related pleural plaques or asbestosis. Long-term studies may reveal whether down-regulation of miR-146b-5p in leukocytes might be an early indicator for an increased cancer risk.},
}
@article {pmid37180489,
year = {2023},
author = {Sekido, Y and Sato, T},
title = {NF2 alteration in mesothelioma.},
journal = {Frontiers in toxicology},
volume = {5},
number = {},
pages = {1161995},
pmid = {37180489},
issn = {2673-3080},
abstract = {The NF2 tumor suppressor gene is a frequent somatically mutated gene in mesothelioma, with 30%-40% mesotheliomas showing NF2 inactivation. NF2 encodes merlin, a member of the ezrin, radixin, and moesin (ERM) family of proteins that regulate cytoskeleton and cell signaling. Recent genome analysis revealed that NF2 alteration may be a late event in mesothelioma development, suggesting that NF2 mutation confers a more aggressive phenotype to mesothelioma cells and may not be directly caused by asbestos exposure. The Hippo tumor-suppressive and mTOR prooncogenic signaling pathways are crucial cell-signaling cascades regulated by merlin. Although the exact role and timing of NF2 inactivation in mesothelioma cells remain to be elucidated, targeting the NF2/merlin-Hippo pathway may be a new therapeutic strategy for patients with mesothelioma.},
}
@article {pmid37178944,
year = {2023},
author = {Brown, JS},
title = {Comparison of Oncogenes, Tumor Suppressors, and MicroRNAs Between Schizophrenia and Glioma: The Balance of Power.},
journal = {Neuroscience and biobehavioral reviews},
volume = {151},
number = {},
pages = {105206},
doi = {10.1016/j.neubiorev.2023.105206},
pmid = {37178944},
issn = {1873-7528},
mesh = {Humans ; *MicroRNAs/genetics/metabolism ; *Schizophrenia/genetics ; Oncogenes ; *Glioma/genetics ; },
abstract = {The risk of cancer in schizophrenia has been controversial. Confounders of the issue are cigarette smoking in schizophrenia, and antiproliferative effects of antipsychotic medications. The author has previously suggested comparison of a specific cancer like glioma to schizophrenia might help determine a more accurate relationship between cancer and schizophrenia. To accomplish this goal, the author performed three comparisons of data; the first a comparison of conventional tumor suppressors and oncogenes between schizophrenia and cancer including glioma. This comparison determined schizophrenia has both tumor-suppressive and tumor-promoting characteristics. A second, larger comparison between brain-expressed microRNAs in schizophrenia with their expression in glioma was then performed. This identified a core carcinogenic group of miRNAs in schizophrenia offset by a larger group of tumor-suppressive miRNAs. This proposed "balance of power" between oncogenes and tumor suppressors could cause neuroinflammation. This was assessed by a third comparison between schizophrenia, glioma and inflammation in asbestos-related lung cancer and mesothelioma (ALRCM). This revealed that schizophrenia shares more oncogenic similarity to ALRCM than glioma.},
}
@article {pmid37175892,
year = {2023},
author = {Cugliari, G},
title = {FKBP5, a Modulator of Stress Responses Involved in Malignant Mesothelioma: The Link between Stress and Cancer.},
journal = {International journal of molecular sciences},
volume = {24},
number = {9},
pages = {},
pmid = {37175892},
issn = {1422-0067},
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/pathology ; *Pleural Neoplasms/pathology ; *Asbestos/toxicity ; *Lung Neoplasms/pathology ; },
abstract = {Malignant pleural mesothelioma (MPM) is a rare tumour characterized by a long latency period after asbestos exposure and poor survival [...].},
}
@article {pmid37172528,
year = {2023},
author = {Du, X and Li, X and Zhang, B and Hao, Z and Gao, Y and Jiang, X and Yang, Z and Chen, Y},
title = {The clinicopathological significance of TOP2A expression in malignant peritoneal mesothelioma.},
journal = {Annals of diagnostic pathology},
volume = {65},
number = {},
pages = {152155},
doi = {10.1016/j.anndiagpath.2023.152155},
pmid = {37172528},
issn = {1532-8198},
mesh = {Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; *Asbestos ; Ki-67 Antigen/metabolism ; *Lung Neoplasms/pathology ; *Mesothelioma/diagnosis ; *Mesothelioma, Malignant ; *Peritoneal Neoplasms ; *Pleural Neoplasms/metabolism/pathology ; Prognosis ; },
abstract = {BACKGROUND: Malignant peritoneal mesothelioma (MPM) is a rare malignant tumor with a high mortality rate and extremely poor prognosis. TOP2A expression is associated with cell proliferation and cell cycle progression. We aimed to demonstrate the expression profile of TOP2A in MPM and its correlation with clinicopathological features.<br><br>METHODS: Clinicopathological information from 100 MPM cases was collected at Beijing Shijitan Hospital, Capital Medical University. Immunohistochemistry (IHC) was performed to evaluate TOP2A levels. The associations between TOP2A levels and clinicopathological features or prognosis were analyzed. Clinical follow-up data were reviewed to determine correlations among the pathological prognostic factors using the Kaplan-Meier estimator and univariate/multivariate Cox proportional hazards regression models.<br><br>RESULTS: Among the 100 MPM patients, there were 48 males and 52 females, with a median age of 54&#xa0;years (range: 24-72&#xa0;years). The cutoff curve was used to find the boundary value of the TOP2A-positive rate. TOP2A positive rate&#xa0;&#x2265;&#xa0;11.97&#xa0;% accounted for 48&#xa0;% in tumor tissue. The TOP2A-positive rate was not associated with sex, age, asbestos exposure, peritoneal carcinomatosis index (PCI) score, or completeness of cytoreduction (CC) score in MPM. Univariate analysis revealed survival-related pathological parameters, including asbestos exposure, CA125, histological type, PCI score, CC score, Ki-67 index, and TOP2A positive rate. Multivariate analysis identified that asbestos exposure history, PCI score, Ki-67 proliferation index and TOP2A positive rate in tissue are independent prognostic factors.<br><br>CONCLUSIONS: High expression of TOP2A is linked to better prognosis of MPM.},
}
@article {pmid37168168,
year = {2023},
author = {Singh, R and Frank, AL},
title = {Does the Presence of Asbestos-Containing Materials in Buildings Post-construction and Before Demolition Have an Impact on the Exposure to Occupants in Non-occupational Settings?.},
journal = {Cureus},
volume = {15},
number = {4},
pages = {e37305},
pmid = {37168168},
issn = {2168-8184},
abstract = {This narrative review aims to determine if asbestos-containing materials in buildings pose a hazard to building occupants in non-occupational settings. This paper is limited to the post-construction and pre-demolition stages of a building. The researchers selected 19 studies from the 126 studies screened, concerning exposure to asbestos fibers in non-occupational building settings, with a focus on post-construction and pre-demolition phases. The literature review found that certain conditions, such as the measurement techniques, standards, and previous data availability, prevent a conclusive answer to the research question. Some studies have pointed towards an effect of asbestos-containing materials on health of occupants in non-occupational settings. But, there are some that do not suggest a positive relationship between non-occupational exposure and the presence of asbestos-containing materials, and therefore these provide scope for further research, as these studies also do not rule out the relationship completely. The present study highlights the gaps in current knowledge and indicates areas for further research. Until conclusive evidence based on revised threshold standards and accurate measurement techniques is available, asbestos-containing materials may be considered unsafe for use in non-occupational settings, especially ones that young people and children occupy.},
}
@article {pmid37167572,
year = {2023},
author = {Hathaway, F and Martins, R and Sorscher, S and Bzura, A and Dudbridge, F and Fennell, DA},
title = {Family Matters: Germline Testing in Thoracic Cancers.},
journal = {American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting},
volume = {43},
number = {},
pages = {e389956},
doi = {10.1200/EDBK_389956},
pmid = {37167572},
issn = {1548-8756},
mesh = {Humans ; *Lung Neoplasms/diagnosis/epidemiology/etiology ; ErbB Receptors/genetics ; *Carcinoma, Non-Small-Cell Lung ; Mutation ; Tumor Suppressor Proteins/genetics/metabolism ; Protein Kinase Inhibitors ; *Mesothelioma ; *Mesothelioma, Malignant ; *Asbestos ; Germ-Line Mutation ; Germ Cells/metabolism ; Genetic Predisposition to Disease ; },
abstract = {Most thoracic cancers arise via a series of stepwise somatic alterations driven by a well-defined carcinogen (ie, tobacco or asbestos for lung cancer and mesothelioma, respectively). A small proportion can emerge on a background of pathogenic germline variants (PGVs), which have the property of heritability. In general, PGVs may be initially suspected on the basis of the presence of specific clinical features. Such gene × environment interactions significantly increase the risk of developing lung cancer (1.5- to 3.2-fold). PGVs have been discovered involving the actionable driver oncogene, epidermal growth factor receptor (EGFR), with an EGFR T790M PGV rate of 0.3%-0.9% in the nonsquamous non-small-cell lung cancer subtype. Its appearance during routine somatic DNA sequencing in those patients who have not had a previous tyrosine kinase inhibitor should raise suspicion. In patients with sporadic mesothelioma, BAP1 is the most frequently mutated tumor driver, with a PGV rate between 2.8% and 8%, associated with a favorable prognosis. BAP1 PGVs accelerate mesothelioma tumorigenesis after asbestos exposure in preclinical models and may be partly predicted by clinical criteria. At present, routine germline genetic testing for thoracic cancers is not a standard practice. Expert genetic counseling is, therefore, required for patients who carry a PGV. Ongoing studies aim to better understand the natural history of patients harboring PGVs to underpin future cancer prevention, precise counseling, and cancer management with the goal of improving the quality and length of life.},
}
@article {pmid37165917,
year = {2023},
author = {Sato, T and Akao, K and Sato, A and Tsujimura, T and Mukai, S and Sekido, Y},
title = {Aberrant expression of NPPB through YAP1 and TAZ activation in mesothelioma with Hippo pathway gene alterations.},
journal = {Cancer medicine},
volume = {12},
number = {12},
pages = {13586-13598},
pmid = {37165917},
issn = {2045-7634},
mesh = {Humans ; Hippo Signaling Pathway ; *Mesothelioma, Malignant ; *Mesothelioma/genetics ; *Pleural Effusion ; Protein Serine-Threonine Kinases/genetics/metabolism ; Tumor Suppressor Proteins/metabolism ; },
abstract = {BACKGROUND: Mesothelioma is a neoplastic disease associated with asbestos exposure. It is highly malignant and has a poor prognosis; thus, early detection is desirable. Recent whole-genome analysis has revealed that mesothelioma is characterized by a high frequency of mutations in a set of genes involved in the Hippo pathway, such as NF2 and LATS2. However, a rapid, simple, and precise method for finding mesothelioma with these mutations has not yet been established.<br><br>METHODS: Clustering of Hippo pathway gene alteration groups and the differential expression of each gene in mesothelioma patients were analyzed using The Cancer Genome Atlas database. Gene expression levels in various tumors and normal tissues were analyzed using public databases. Knockdown or transient expression of YAP1 or TAZ was performed to evaluate the regulation of gene expression by these genes. NT-proBNP was measured in the pleural effusions of 18 patients and was compared with NF2 expression in five cases where cell lines had been successfully established.<br><br>RESULTS: NPPB mRNA expression was markedly higher in the group of mesothelioma patients with Hippo pathway gene mutations than in the group without them. NPPB expression was low in all normal tissues except heart, and was highest in mesothelioma. Mesothelioma patients in the high NPPB expression group had a significantly worse prognosis than those in the low NPPB expression group. NPPB expression was suppressed by knockdown of YAP1 or TAZ. NT-proBNP was abundant in the effusions of mesothelioma patients and was particularly high in those with impaired NF2 expression.<br><br>CONCLUSIONS: NPPB, whose levels can be measured in pleural effusions of mesothelioma patients, has the potential to act as a biomarker to detect NF2-Hippo pathway gene alterations and/or predict patient prognosis. Additionally, it may provide useful molecular insights for a better understanding of mesothelioma pathogenesis and for the development of novel therapies.},
}
@article {pmid37158685,
year = {2023},
author = {Moline, J},
title = {Response to the Letter to the Editor From Jeffrey Brent, MD, PhD. Re: Mesothelioma Associated With the Use of Cosmetic Talc.},
journal = {Journal of occupational and environmental medicine},
volume = {65},
number = {5},
pages = {e361},
doi = {10.1097/JOM.0000000000002840},
pmid = {37158685},
issn = {1536-5948},
mesh = {Humans ; Talc/adverse effects ; *Mesothelioma/chemically induced ; *Mesothelioma, Malignant ; },
}
@article {pmid37150820,
year = {2023},
author = {Avramescu, ML and Potiszil, C and Kunihiro, T and Okabe, K and Nakamura, E},
title = {An investigation of the internal morphology of asbestos ferruginous bodies: constraining their role in the onset of malignant mesothelioma.},
journal = {Particle and fibre toxicology},
volume = {20},
number = {1},
pages = {19},
pmid = {37150820},
issn = {1743-8977},
mesh = {Animals ; Mice ; *Mesothelioma, Malignant/pathology ; Smoking/adverse effects ; *Asbestos/toxicity/analysis ; Lung ; *Lung Neoplasms/chemically induced/pathology ; *Mesothelioma/chemically induced/pathology ; },
abstract = {BACKGROUND: Asbestos is a fibrous mineral that was widely used in the past. However, asbestos inhalation is associated with an aggressive type of cancer known as malignant mesothelioma (MM). After inhalation, an iron-rich coat forms around the asbestos fibres, together the coat and fibre are termed an "asbestos ferruginous body" (AFB). AFBs are the main features associated with asbestos-induced MM. Whilst several studies have investigated the external morphology of AFBs, none have characterised the internal morphology. Here, cross-sections of multiple AFBs from two smokers and two non-smokers are compared to investigate the effects of smoking on the onset and growth of AFBs. Morphological and chemical observations of AFBs were undertaken by transmission electron microscopy, energy dispersive x-ray spectroscopy and selected area diffraction.<br><br>RESULTS: The AFBs of all patients were composed of concentric layers of 2-line or 6-line ferrihydrite, with small spherical features being observed on the outside of the AFBs and within the cross-sections. The spherical components are of a similar size to Fe-rich inclusions found within macrophages from mice injected with asbestos fibres in a previous study. As such, the spherical components composing the AFBs may result from the deposition of Fe-rich inclusions during frustrated phagocytosis. The AFBs were also variable in terms of their Fe, P and Ca abundances, with some layers recording higher Fe concentrations (dense layers), whilst others lower Fe concentrations (porous layers). Furthermore, smokers were found to have smaller and overall denser AFBs than non-smokers.<br><br>CONCLUSIONS: The AFBs of smokers and non-smokers show differences in their morphology, indicating they grew in lung environments that experienced disparate conditions. Both the asbestos fibres of smokers and non-smokers were likely subjected to frustrated phagocytosis and accreted mucopolysaccharides, resulting in Fe accumulation and AFB formation. However, smokers' AFBs experienced a more uniform Fe-supply within the lung environment compared to non-smokers, likely due to Fe complexation from cigarette smoke, yielding denser, smaller and more Fe-rich AFBs. Moreover, the lack of any non-ferrihydrite Fe phases in the AFBs may indicate that the ferritin shell was intact, and that ROS may not be the main driver for the onset of MM.},
}
@article {pmid37147569,
year = {2023},
author = {Liang, Y and Li, C and Liu, Y and Tian, L and Yang, D},
title = {Prognostic role of CD74, CD10 and Ki-67 immunohistochemical expression in patients with diffuse malignant peritoneal mesothelioma: a retrospective study.},
journal = {BMC cancer},
volume = {23},
number = {1},
pages = {406},
pmid = {37147569},
issn = {1471-2407},
support = {2016-304//Cangzhou Finance Bureau/ ; },
mesh = {Humans ; Male ; Female ; Middle Aged ; Prognosis ; Retrospective Studies ; Ki-67 Antigen/metabolism ; *Mesothelioma/pathology ; *Percutaneous Coronary Intervention ; Biomarkers, Tumor/metabolism ; *Mesothelioma, Malignant ; *Peritoneal Neoplasms/drug therapy ; },
abstract = {BACKGROUND: Diagnosis and treatment of diffuse malignant peritoneal mesothelioma (DMPM) are still challenging. The aim of the present study was to explore the correlation between CD74, CD10, Ki-67 and clinicopathological parameters, and identify independent prognostic factors of DMPM.<br><br>METHODS: Seventy patients with pathologically proven DMPM were retrospectively reviewed. The expression of CD74, CD10 and Ki-67 in peritoneal tissues was detected by immunohistochemical analysis using standard avidin biotin complex (ABC) immunostaining technique. Kaplan-Meier survival analysis and multivariate Cox regression analyses were performed to assess prognostic factors. The nomogram based on the Cox hazards regression model was established. C-index and calibration curve were performed to evaluate the accuracy of nomogram models.<br><br>RESULTS: The median age of DMPM was 62.34&#xa0;years, and the male-to-female ratio was 1: 1.80. CD74 expression was identified in 52 (74.29%) of 70 specimens, CD10 in 34 (48.57%) specimens, and higher Ki-67 in 33(47.14%) specimens. CD74 was negatively associated with asbestos exposure(r&#x2009;=&#x2009;-0.278), Ki-67(r&#x2009;=&#x2009;-0.251) and TNM stage(r&#x2009;=&#x2009;-0.313). All patients were effectively&#xa0;followed&#xa0;up in the survival analysis. Univariate analysis revealed that PCI, TNM stage, treatment, Ki-67, CD74 and ECOG PS were associated with DMPM prognosis. CD74 (HR&#x2009;=&#x2009;0.65, 95%Cl:0.46-0.91, P&#x2009;=&#x2009;0.014), Ki-67(HR&#x2009;=&#x2009;2.09, 95%Cl:1.18-3.73, P&#x2009;=&#x2009;0.012),TNM stage (HR&#x2009;=&#x2009;1.89, 95%Cl:1.16-3.09, P&#x2009;=&#x2009;0.011), ECOG PS(HR&#x2009;=&#x2009;2.12, 95%Cl:1.06-4.25, P&#x2009;=&#x2009;0.034), systemic chemotherapy (HR&#x2009;=&#x2009;0.41, 95%Cl:0.21-0.82, P&#x2009;=&#x2009;0.011) and intraperitoneal chemotherapy (HR&#x2009;=&#x2009;0.34, 95%Cl:0.16-0.71, P&#x2009;=&#x2009;0.004) were independent predictors by multivariate Cox analysis. The C&#x2011;index of the nomogram for predicting overall survival (OS) was 0.81. The OS calibration curve showed good agreement between nomogram-predicted and observed survival.<br><br>CONCLUSIONS: CD74, Ki-67, TNM stage, ECOG PS and treatment were independent factors affecting prognosis of DMPM. Reasonable chemotherapy treatment might improve the prognosis of patients. The proposed nomogram was a visual tool to effectively predict the OS of DMPM patients.},
}
@article {pmid37147272,
year = {2023},
author = {Yang, D and Chen, C and Xia, H and Chen, J and Yu, M},
title = {Characteristics of transcription profile, adhesion and migration of SETD2-loss Met-5A mesothelial cells exposed with crocidolite.},
journal = {Journal of applied toxicology : JAT},
volume = {43},
number = {10},
pages = {1511-1521},
doi = {10.1002/jat.4493},
pmid = {37147272},
issn = {1099-1263},
mesh = {Humans ; Asbestos, Crocidolite/toxicity/metabolism ; Epithelium ; *Asbestos/toxicity ; *Mesothelioma ; Silicates ; Cell Adhesion Molecule-1/metabolism ; },
abstract = {Asbestos is a fibrous silicate mineral exhibiting biopersistence and carcinogenic properties and contributes to mesothelioma. Despite the concept of gene-environmental interaction in pathogenesis of mesothelioma, the possible pathophysiological changes of mesothelial cells simultaneously with SET domain containing 2 (SETD2) loss and asbestos exposure remains obscure. Herein, CRISPR/Cas9-mediated SETD2 knockout Met-5A mesothelial cells (Met-5A[SETD2-KO]) were established and exposed with crocidolite, an amphibole asbestos. Cell viability of Met-5A[SETD2-KO] appeared to dramatically decrease with ≥2.5 μg/cm[2] crocidolite exposure as compared with Met-5A, although no cytotoxicity and apoptosis changes of Met-5A[SETD2-KO] and Met-5A was evident with 1.25 μg/cm[2] crocidolite exposure for 48 h. RNA sequencing uncovered top 50 differentially expressed genes (DEGs) between 1.25 μg/cm[2] crocidolite exposed Met-5A[SETD2-KO] (Cro-Met-5A[SETD2-KO]) and 1.25 μg/cm[2] crocidolite exposed Met-5A (Cro-Met-5A), and ITGA4, THBS2, MYL7, RAC2, CADM1, and CLDN11 appeared to be the primary DEGs involved with adhesion in gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Cro-Met-5A[SETD2-KO] had strong migration but mild adhesion behavior as compared with Cro-Met-5A. Additionally, crocidolite tended to increase migration of Met-5A[SETD2-KO] but inhibited migration of Met-5A when compared with their corresponding cells without crocidolite exposure, although no further adhesion property changes was evident for both cells in response to crocidolite. Therefore, crocidolite may affect adhesion-related gene expression and modify adhesion and migration behavior for SETD2-depleted Met-5A, which could provide preliminary insight regarding the potential role of SETD2 in the cell behavior of asbestos-related malignant mesothelial cell.},
}
@article {pmid37146474,
year = {2023},
author = {Tada, A and Minami, T and Kitai, H and Higashiguchi, Y and Tokuda, M and Higashiyama, T and Negi, Y and Horio, D and Nakajima, Y and Otsuki, T and Mikami, K and Takahashi, R and Nakamura, A and Kitajima, K and Ohmuraya, M and Kuribayashi, K and Kijima, T},
title = {Combination therapy with anti-programmed cell death 1 antibody plus angiokinase inhibitor exerts synergistic antitumor effect against malignant mesothelioma via tumor microenvironment modulation.},
journal = {Lung cancer (Amsterdam, Netherlands)},
volume = {180},
number = {},
pages = {107219},
doi = {10.1016/j.lungcan.2023.107219},
pmid = {37146474},
issn = {1872-8332},
mesh = {Humans ; Female ; Animals ; Mice ; Cell Line, Tumor ; Mice, Inbred C57BL ; *Mesothelioma, Malignant/drug therapy ; *Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; *Indoles/therapeutic use ; *Programmed Cell Death 1 Receptor/antagonists &amp; inhibitors ; *Protein Kinase Inhibitors/therapeutic use ; *Angiogenesis Inhibitors/therapeutic use ; *Antibodies, Monoclonal/therapeutic use ; Allografts ; },
abstract = {Malignant pleural mesothelioma (MPM) is an asbestos-related fatal malignant neoplasm. Although there has been no reliable chemotherapeutic regimen other than combination therapy of cisplatin and pemetrexed for two decades, combination of ipilimumab plus nivolumab brought about a better outcome in patients with MPM. Thus, cancer immunotherapy using immune checkpoint inhibitor (ICI) is expected to play a central role in the treatment of MPM. To maximize the antitumor effect of ICI, we evaluated whether nintedanib, an antiangiogenic agent, could augment the antitumor effect of anti-programmed cell death 1 (PD-1) antibody (Ab). Although nintedanib could not inhibit the proliferation of mesothelioma cells in vitro, it significantly suppressed the growth of mesothelioma allografts in mice. Moreover, combination therapy with anti-PD-1 Ab plus nintedanib reduced tumor burden more dramatically compared with nintedanib monotherapy via inducing remarkable necrosis in MPM allografts. Nintedanib did not promote the infiltration of CD8[+] T cells within the tumor when used alone or in combination with anti-PD-1 Ab but it independently decreased the infiltration of tumor-associated macrophages (TAMs). Moreover, immunohistochemical analysis and ex vivo study using bone marrow-derived macrophages (BMDMs) showed that nintedanib could polarize TAMs from M2 to M1 phenotype. These results indicated that nintedanib had a potential to suppress protumor activity of TAMs both numerically and functionally. On the other hand, ex vivo study revealed that nintedanib upregulated the expression of PD-1 and PD-ligand 1 (PD-L1) in BMDMs and mesothelioma cells, respectively, and exhibited the impairment of phagocytic activity of BMDMs against mesothelioma cells. Co-administration of anti-PD-1 Ab may reactivate phagocytic activity of BMDMs by disrupting nintedanib-induced immunosuppressive signal via binding between PD-1 on BMDMs and PD-L1 on mesothelioma cells. Collectively, combination therapy of anti-PD-1 Ab plus nintedanib enhances the antitumor activity compared with respective monotherapy and can become a novel therapeutic option for patients with MPM.},
}
@article {pmid37146029,
year = {2023},
author = {Orozco Morales, ML and Rinaldi, CA and de Jong, E and Lansley, SM and Lee, YCG and Zemek, RM and Bosco, A and Lake, RA and Lesterhuis, WJ},
title = {Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma.},
journal = {PloS one},
volume = {18},
number = {5},
pages = {e0274364},
pmid = {37146029},
issn = {1932-6203},
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/drug therapy/genetics ; *Pleural Neoplasms/pathology ; Cell Proliferation ; *Lung Neoplasms/drug therapy/genetics/pathology ; },
abstract = {Mesothelioma is characterised by its aggressive invasive behaviour, affecting the surrounding tissues of the pleura or peritoneum. We compared an invasive pleural model with a non-invasive subcutaneous model of mesothelioma and performed transcriptomic analyses on the tumour samples. Invasive pleural tumours were characterised by a transcriptomic signature enriched for genes associated with MEF2C and MYOCD signaling, muscle differentiation and myogenesis. Further analysis using the CMap and LINCS databases identified geldanamycin as a potential antagonist of this signature, so we evaluated its potential in vitro and in vivo. Nanomolar concentrations of geldanamycin significantly reduced cell growth, invasion, and migration in vitro. However, administration of geldanamycin in vivo did not result in significant anti-cancer activity. Our findings show that myogenesis and muscle differentiation pathways are upregulated in pleural mesothelioma which may be related to the invasive behaviour. However, geldanamycin as a single agent does not appear to be a viable treatment for mesothelioma.},
}
@article {pmid37139482,
year = {2023},
author = {Ma, GY and Shi, S and Sang, YZ and Wang, P and Zhang, ZG},
title = {High Expression of SMO and GLI1 Genes with Poor Prognosis in Malignant Mesothelioma.},
journal = {BioMed research international},
volume = {2023},
number = {},
pages = {6575194},
pmid = {37139482},
issn = {2314-6141},
mesh = {Humans ; *Mesothelioma, Malignant/genetics ; Zinc Finger Protein GLI1/genetics/metabolism ; Lymphatic Metastasis ; Signal Transduction ; Hedgehog Proteins/genetics ; *Mesothelioma/genetics/pathology ; Prognosis ; RNA, Messenger/genetics ; Biomarkers, Tumor/genetics/metabolism ; Smoothened Receptor/genetics ; },
abstract = {BACKGROUND: To investigate the value of SMO and GLI1 genes in the hedgehog pathway in malignant mesothelioma specimens. Further study on the expression and prognosis of SMO and GLI1 in malignant mesothelioma tissues and the relationship between the two and the molecular mechanisms of mesothelioma immunity and to further investigate the prognostic value of mesothelioma expression.<br><br>MATERIALS AND METHODS: Immunohistochemistry and RT-qPCR were applied to detect the expression of SMO and GLI1 proteins and mRNA in biopsy specimens and plasma cavity effusion specimens from malignant mesothelioma (n = 130) and benign mesothelial tissues (n = 50) and to analyze the clinicopathological significance and survival risk factors of SMO and GLI1 protein expression in mesothelioma. The mechanisms of mesothelioma cell expression and immune cell infiltration were investigated using bioinformatics methods.<br><br>RESULTS: SMO and GLI1 in mesothelioma tissues detected high concordance between the diagnostic results of mesothelioma biopsy specimens and plasma cavity effusion specimens. The expression levels of SMO and GLI1 protein and mRNA in mesothelioma tissues were higher than those in benign mesothelioma tissues. The expression levels of SMO and GLI1 protein were correlated with the age, site, and asbestos exposure history of patients with mesothelioma. The expression levels of SMO and GLI1 protein were correlated with the expressions of ki67 and p53 (P < 0.05). SMO and GLI1 gene expression levels were negatively correlated with good prognosis in mesothelioma patients (P < 0.05). Cox proportional risk model indicated that protein expressions of invasion, lymph node metastasis, distant metastasis, staging, and genes were independent prognostic factors of mesothelioma. The GEPIA database showed the overall survival rate and the disease-free survival rate of mesothelioma patients in the high SMO and GLI1 expression groups; the UALCAN database analysis showed lower SMO expression levels in mesothelioma patients with more pronounced TP53 mutations (P = 0.001); GLI1 gene expression levels were strongly correlated with lymph node metastasis in mesothelioma patients (P = 0.009). Timer database analysis showed that the mechanism of immune cell infiltration was closely related to SMO and GLI1 expression. The degree of immune cell infiltration was strongly correlated with the prognosis of mesothelioma patients (P < 0.05).<br><br>CONCLUSION: The expression levels of both SMO and GLI1 proteins were higher than those of normal mesothelial tissues, and the mRNA expression levels also changed in the same direction. SMO and GLI1 gene expressions in mesothelioma were negatively correlated with age, site of occurrence, and history of asbestos exposure. Positive expression of SMO and GLI1 was negatively correlated with patient survival. The Cox proportional risk model showed that gender, history of asbestos exposure, site of occurrence, SMO, and GLI1 were independent prognostic factors for mesothelioma. The mechanism of immune cell infiltration in mesothelioma is closely related to the gene expression of both and the survival prognosis of mesothelioma patients.},
}
@article {pmid37131285,
year = {2023},
author = {Abdelghafar, M and Anand, K and Paiva-Correia, A and Smith, EP and Salle, FG and Joshi, V},
title = {Well-Differentiated Papillary Mesothelial Tumor: An Unusual Radiologic Presentation: A Case Report.},
journal = {Journal of chest surgery},
volume = {56},
number = {3},
pages = {220-223},
pmid = {37131285},
issn = {2765-1606},
abstract = {Well-differentiated papillary mesothelial tumor (WDPMT) is an uncommon tumor, formerly named well-differentiated papillary mesothelioma in the 2015 World Health Organization classification. It has a characteristic papillary architecture, bland cytologic features, a tendency toward superficial spread without invasion, and a good prognosis due to its clinically indolent behavior with prolonged survival. Rare cases with superficial invasion are termed WDPMT with invasive foci. WDPMT occurs primarily in the peritoneum of reproductive-age women, but also rarely in the pleura. We report a case of a 60-year-old woman who developed WDPMT with minimal invasion in the pleura with atypical radiological features and a family history of mesothelioma and indirect asbestos exposure.},
}
@article {pmid37128670,
year = {2024},
author = {Marshall, T and Lane, J and Lahorra, J},
title = {A Rare Presentation of Minimally Invasive Mesothelioma as a Large Tension Pneumothorax.},
journal = {International journal of surgical pathology},
volume = {32},
number = {1},
pages = {109-114},
doi = {10.1177/10668969231167492},
pmid = {37128670},
issn = {1940-2465},
mesh = {Male ; Humans ; Aged, 80 and over ; *Pneumothorax/diagnosis/etiology/surgery ; *Mesothelioma/complications/diagnosis/surgery ; *Mesothelioma, Malignant/complications ; Pleura/surgery ; *Pleural Effusion/complications ; *Pleural Neoplasms/complications/diagnosis/surgery ; },
abstract = {Development of mesothelioma is associated with asbestos exposure. Common presentations are with pleural-based plaques invading the chest wall and/or pleural effusion on chest imaging. The intent of this case report is to describe a rare presentation of mesothelioma, which presented atypically as a large tension pneumothorax. A 93-year-old male presented with a history of dyspnea that started after a coughing episode. On physical examination he was hemodynamically stable, but was hypoxic requiring 2L of supplemental oxygen. Computed tomography of the chest revealed a large right tension pneumothorax. A chest tube was placed and connected to suction (-20cmH20), but he continued to have an unresolving air leak over the following 2-week period. Upon video-assisted thoracotomy there were no blebs or adhesions seen. Right apical wedge resection and talc pleurodesis were performed. Pathologic examination revealed an atypical mesothelial cell proliferation with minimal, focal invasion into the pulmonary parenchyma. Tumor spread along the visceral pleura was thought to be the underlying cause of the pneumothorax. The surgical margins were uninvolved by the tumor, and the patient was later discharged home in stable condition. This was a rare presentation of what could best be described as minimally invasive mesothelioma arising in a background of probable mesothelioma in situ, which presented atypically as a large tension pneumothorax. This case highlighted the importance of establishing a pathologic diagnosis from pleural effusion cytology and/or pleural biopsy in persons presenting with spontaneous pneumothorax, and the difficulty in confirming a pathologic diagnosis of early mesothelial neoplasia.},
}
@article {pmid37104724,
year = {2023},
author = {Arrossi, AV},
title = {Pericardial Mesotheliomas.},
journal = {Advances in anatomic pathology},
volume = {30},
number = {4},
pages = {253-258},
doi = {10.1097/PAP.0000000000000399},
pmid = {37104724},
issn = {1533-4031},
mesh = {Humans ; Prospective Studies ; *Mesothelioma, Malignant/complications ; *Mesothelioma/diagnosis/pathology ; *Pleural Neoplasms/diagnosis/etiology/pathology ; *Sarcoma/pathology ; *Heart Neoplasms/diagnosis ; },
abstract = {Primary pericardial mesothelioma (PM) is a rare tumor arising from the mesothelial cells of the pericardium. It has an incidence of <0.05% and comprises <2% of all mesotheliomas; however, it is the most common primary malignancy of the pericardium. PM should be distinguished from secondary involvement by the spread of pleural mesothelioma or metastases, which are more common. Although data are controversial, the association between asbestos exposure and PM is less documented than that with other mesotheliomas. Late clinical presentation is common. Symptoms may be nonspecific but are usually related to pericardial constriction or cardiac tamponade, and diagnosis can be challenging usually requiring multiple imaging modalities. Echocardiography, computed tomography, and cardiac magnetic resonance demonstrate heterogeneously enhancing thickened pericardium, usually encasing the heart, with findings of constrictive physiology. Tissue sampling is essential for diagnosis. Histologically, similar to mesotheliomas elsewhere in the body, PM is classified as epithelioid, sarcomatoid, or biphasic, with the biphasic type being the most common. Combined with morphologic assessment, the use of immunohistochemistry and other ancillary studies is helpful for distinguishing mesotheliomas from benign proliferative processes and other neoplastic processes. The prognosis of PM is poor with about 22% 1-year survival. Unfortunately, the rarity of PM poses limitations for comprehensive and prospective studies to gain further insight into the pathobiology, diagnosis, and treatment of PM.},
}
@article {pmid37101434,
year = {2022},
author = {Vicari, K and Ribeiro, IM and Aguiar, BF and Brey, C and Boller, S and Miranda, FMD},
title = {Occupational characterization of workers exposed to asbestos: an integrative review.},
journal = {Revista brasileira de medicina do trabalho : publicacao oficial da Associacao Nacional de Medicina do Trabalho-ANAMT},
volume = {20},
number = {4},
pages = {650-658},
pmid = {37101434},
issn = {1679-4435},
abstract = {Asbestos is a mineral fiber abundant in nature and classified as a carcinogen since 1987. The present study aimed to identify, in the scientific literature, what are the occupation and activities developed by sick workers and which categories would be affected with asbestos-related diseases. Through a literature review performed in the following databases: PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Web of Science, and Regional Portal of the Virtual Health Library, 23 studies published from 2015 to 2020 were selected and evaluated. The occupations that showed greater illness due to exposure to asbestos were general asbestos workers (40%), miners (22%), and textile workers (9%), followed by naval, automotive, carpentry, doll-making, construction, and upholstery workers, as well as workers involved in the rescue, recovery, cleaning, and restoration of the World Trade Center (4%). Of the disease associated with exposure to asbestos, the most described is malignant mesothelioma (43%). Evidence found corroborate pre-existing information in the literature showing that exposure to asbestos may be harmful to health. Moreover, the importance of using personal protective equipment was emphasized, in order to prevent the development of asbestos-related diseases.},
}
@article {pmid37095543,
year = {2023},
author = {Tomasetti, M and Monaco, F and Strogovets, O and Volpini, L and Valentino, M and Amati, M and Neuzil, J and Santarelli, L},
title = {ATG5 as biomarker for early detection of malignant mesothelioma.},
journal = {BMC research notes},
volume = {16},
number = {1},
pages = {61},
pmid = {37095543},
issn = {1756-0500},
mesh = {Humans ; *Mesothelioma, Malignant ; Mesothelin ; *Mesothelioma/diagnosis ; GPI-Linked Proteins/adverse effects ; *Pleural Neoplasms/diagnosis ; Biomarkers, Tumor/metabolism ; *Asbestos/adverse effects ; *MicroRNAs ; Early Diagnosis ; *Lung Neoplasms/diagnosis ; Autophagy-Related Protein 5 ; },
abstract = {OBJECTIVES: Malignant pleural mesothelioma (MPM) is an aggressive disease with grim prognosis due to lack of effective treatment options. Disease prediction in association with early diagnosis may both contribute to improved MPM survival. Inflammation and autophagy are two processes associated with asbestos-induced transformation. We evaluated the level of two autophagic factors ATG5 and HMGB1, microRNAs (miRNAs) such as miR-126 and miR-222, and the specific biomarker of MPM, soluble mesothelin related proteins (Mesothelin) in asbestos-exposed individuals, MPM patients, and healthy subjects. The performance of these markers in detecting MPM was investigated in pre-diagnostic samples of asbestos-subjects who developed MPM during the follow-up and compared for the three groups.<br><br>RESULTS: The ATG5 best distinguished the asbestos-exposed subjects with and without MPM, while miR-126 and Mesothelin were found as a significant prognostic biomarker for MPM. ATG5 has been identified as an asbestos-related biomarker that can help to detect MPM with high sensitivity and specificity in pre-diagnostic samples for up to two years before diagnosis. To utilize this approach practically, higher number of cases has to be tested in order to give the combination of the two markers sufficient statistical power. Performance of the biomarkers should be confirmed by testing their combination in an independent cohort with pre-diagnostic samples.},
}
@article {pmid37090283,
year = {2023},
author = {Razzak, AN and Syed, A and Procknow, ER and Bequest, A and Jha, P},
title = {Modern Malignant Mesothelioma Manifestation.},
journal = {Cureus},
volume = {15},
number = {3},
pages = {e36479},
pmid = {37090283},
issn = {2168-8184},
abstract = {Malignant pleural mesothelioma (MPM) involves the uncontrolled growth of mesothelial cells that form the lining of pleural serous layers. MPM has been linked with asbestos exposure in mining and manufacturing occupations with an unforgiving prognosis of 4-18 months. In this case report, we present a 56-year-old male with a significant past medical history of hypertension, hyperlipidemia, hepatic steatosis, and ulcerative colitis who presented to the emergency department for worsening cough, eight-pound weight loss over the previous year, night sweats, and fatigue. The patient was admitted due to right pleural effusion with lower lobe collapse seen on imaging; upon diagnostic workup including pleural biopsy, results were consistent with malignant mesothelioma of the epithelioid type. Over the course of six months post-diagnosis, the patient underwent multiple hospital admissions due to acute hypoxic respiratory failure from the segmental left upper lobe and subsegmental right upper lobe pulmonary emboli, recurrent pleural effusion, and anemia. Given the aggressive nature of MPM, the patient was determined not to be a surgical candidate and underwent palliative chemotherapy sessions until his passing. As the patient worked in heating/ventilation/air conditioning with asbestos exposure, taking a full occupational history was crucial. MPM is relatively rare; however, the incidence has increased over the last decade due to tumor development lag time post-asbestos exposure and an increase in do-it-yourself projects. There is no cure for MPM. Multimodal treatment approaches with surgery, chemotherapy, radiotherapy, and immunotherapy have been noted in the literature.},
}
@article {pmid37089484,
year = {2023},
author = {Marsh, GM and Kruchten, A},
title = {A reevaluation of selected mortality risks in the updated NCI/NIOSH acrylonitrile cohort study.},
journal = {Frontiers in public health},
volume = {11},
number = {},
pages = {1122346},
pmid = {37089484},
issn = {2296-2565},
mesh = {United States/epidemiology ; Humans ; Cohort Studies ; *Acrylonitrile ; National Institute for Occupational Safety and Health, U.S. ; *Occupational Exposure/adverse effects ; *Lung Neoplasms ; *Asbestos ; *Urinary Bladder Neoplasms ; },
abstract = {OBJECTIVES: The study aimed to determine whether the National Cancer Institute's (NCI) recent suggestion of associations between acrylonitrile (AN) exposure and mortality in lung and bladder cancer and pneumonitis is robust to alternative methods of data analysis.<br><br>MATERIALS AND METHODS: We used the Richardson method to indirectly adjust risk ratios (RRs) in relation to AN exposure for potential confounding by smoking and asbestos. We repeated key analyses omitting workers from Plant 4 to account for possible local, historical shipyard-related asbestos exposures.<br><br>RESULTS: The adjustment of lung cancer RRs for confounding by both smoking and asbestos and omitting Plant 4 workers yielded mostly decreased RRs and much less evidence of a positive association with cumulative AN exposure.<br><br>CONCLUSION: Overall, our reanalysis provided little evidence to support NCI's suggestion of associations between AN exposure and mortality in lung and bladder cancer and pneumonitis.},
}
@article {pmid37087784,
year = {2023},
author = {Barbieri, PG and Consonni, D and Magnani, C and Mensi, C and Mirabell, D and Ricci, P and Terracini, B},
title = {Is mesothelioma related to "initial dose" rather than to "cumulative dose"? Critical remarks on Maghin et al. Assessment protocol of mesothelioma and relevance of SEM-EDS analysis through a case studies of legal medicine of Brescia (Italy). Legal Medicine 2022;57:102076.},
journal = {Legal medicine (Tokyo, Japan)},
volume = {63},
number = {},
pages = {102262},
doi = {10.1016/j.legalmed.2023.102262},
pmid = {37087784},
issn = {1873-4162},
mesh = {Humans ; *Mesothelioma/diagnosis ; *Occupational Exposure ; Forensic Medicine ; Italy ; },
}
@article {pmid37081052,
year = {2023},
author = {Di Mauro, G and Frontini, F and Torreggiani, E and Iaquinta, MR and Caselli, A and Mazziotta, C and Esposito, V and Mazzoni, E and Libener, R and Grosso, F and Maconi, A and Martini, F and Bononi, I and Tognon, M},
title = {Epigenetic investigation into circulating microRNA 197-3p in sera from patients affected by malignant pleural mesothelioma and workers ex-exposed to asbestos.},
journal = {Scientific reports},
volume = {13},
number = {1},
pages = {6501},
pmid = {37081052},
issn = {2045-2322},
mesh = {Humans ; *Mesothelioma, Malignant/genetics ; *Circulating MicroRNA ; *Mesothelioma/pathology ; *Lung Neoplasms/pathology ; *Pleural Neoplasms/pathology ; *Asbestos/adverse effects ; *MicroRNAs/genetics ; Epigenesis, Genetic ; },
abstract = {The epigenetic role of microRNAs is established at both physiological and pathological levels. Dysregulated miRNAs and their targets appear to be a promising approach for innovative anticancer therapies. In our previous study, circulating miR-197-3p tested dysregulated in workers ex-exposed to asbestos (WEA). Herein, an epigenetic investigation on this circulating miRNA was carried out in sera from malignant pleural mesothelioma (MPM) patients. MiR-197-3p was quantified in MPM (n = 75) sera and comparatively analyzed to WEA (n = 75) and healthy subject (n = 75) sera, using ddPCR and RT-qPCR techniques. Clinicopathological characteristics, occupational, non-occupational information and overall survival (OS) were evaluated in correlation studies. MiR-197-3p levels, analyzed by ddPCR, were significantly higher in MPM than in WEA cohort, with a mean copies/µl of 981.7 and 525.01, respectively. Consistently, RT-qPCR showed higher miR-197-3p levels in sera from MPM with a mean copies/µl of 603.7, compared to WEA with 336.1 copies/µl. OS data were significantly associated with histologic subtype and pleurectomy. Circulating miR-197-3p is proposed as a new potential biomarker for an early diagnosis of the MPM onset. Indeed, miR-197-3p epigenetic investigations along with chest X-ray, computed tomography scan and spirometry could provide relevant information useful to reach an early and effective diagnosis for MPM.},
}
@article {pmid37077094,
year = {2023},
author = {Bulutay, P and Vatansever, D and Taskiran, C and Mericoz, CA and Tokat, F and Kapucuoglu, N and Kulac, I},
title = {STRN-ALK rearranged malignant peritoneal mesothelioma-Presenting with bilateral extensive pelvic masses in a young woman: Mimicking low-grade serous ovarian carcinoma.},
journal = {Indian journal of pathology &amp; microbiology},
volume = {66},
number = {2},
pages = {392-395},
doi = {10.4103/ijpm.ijpm_360_21},
pmid = {37077094},
issn = {0974-5130},
mesh = {Adolescent ; Female ; Humans ; Calmodulin-Binding Proteins/genetics ; *Cystadenocarcinoma, Serous/diagnosis/genetics ; Membrane Proteins/genetics ; *Mesothelioma/diagnosis/pathology ; *Mesothelioma, Malignant ; Nerve Tissue Proteins/genetics/metabolism ; *Ovarian Neoplasms/diagnosis/pathology ; Receptor Protein-Tyrosine Kinases/genetics ; *Anaplastic Lymphoma Kinase/genetics ; },
abstract = {Malignant peritoneal mesothelioma (MPM) is an exceptionally rare tumor type. Although some somatic/germline genetic alterations including BAP1 loss have been identified in some cases, the molecular properties of MPMs are remained poorly understood. In recent years, anaplastic lymphoma kinase (ALK) gene rearrangement was revealed in a subset of (3.4%) MPMs. Low-grade serous carcinomas (LGSCs) are a rare subtype of ovarian carcinoma and have some morphologic and immunophenotypic overlapping features with MPMs and this may cause misdiagnosis in daily practice. Here, we report a case of 18-year-old women with STRN-ALK-rearranged MPM and no previous exposure to asbestos. This case was presented with bilateral pelvic masses and histologically was displaying pure papillary morphology with mild-to-moderate nuclear atypia, psammoma bodies, and diffuse PAX8 expression as LGSCs. With the detection of ALK alteration in some of the MPMs, a targeted treatment option has emerged for these unusual tumor types.},
}
@article {pmid37062308,
year = {2023},
author = {Bolan, S and Kempton, L and McCarthy, T and Wijesekara, H and Piyathilake, U and Jasemizad, T and Padhye, LP and Zhang, T and Rinklebe, J and Wang, H and Kirkham, MB and Siddique, KHM and Bolan, N},
title = {Sustainable management of hazardous asbestos-containing materials: Containment, stabilization and inertization.},
journal = {The Science of the total environment},
volume = {881},
number = {},
pages = {163456},
doi = {10.1016/j.scitotenv.2023.163456},
pmid = {37062308},
issn = {1879-1026},
abstract = {Asbestos is a group of six major silicate minerals that belong to the serpentine and amphibole families, and include chrysotile, amosite, crocidolite, anthophyllite, tremolite and actinolite. Weathering and human disturbance of asbestos-containing materials (ACMs) can lead to the emission of asbestos dust, and the inhalation of respirable asbestos fibrous dust can lead to 'mesothelioma' cancer and other diseases, including the progressive lung disease called 'asbestosis'. There is a considerable legacy of in-situ ACMs in the built environment, and it is not practically or economically possible to safely remove ACMs from the built environment. The aim of the review is to examine the three approaches used for the sustainable management of hazardous ACMs in the built environment: containment, stabilization, and inertization or destruction. Most of the asbestos remaining in the built environment can be contained in a physically secured form so that it does not present a significant health risk of emitting toxic airborne fibres. In settings where safe removal is not practically feasible, stabilization and encapsulation can provide a promising solution, especially in areas where ACMs are exposed to weathering or disturbance. Complete destruction and inertization of asbestos can be achieved by thermal decomposition using plasma and microwave radiation. Bioremediation and chemical treatment (e.g., ultrasound with oxalic acid) have been found to be effective in the inertization of ACMs. Technologies that achieve complete destruction of ACMs are found to be attractive because the treated products can be recycled or safely disposed of in landfills.},
}
@article {pmid37058192,
year = {2023},
author = {Bardelli, F and Giacobbe, C and Ballirano, P and Borelli, V and Di Benedetto, F and Montegrossi, G and Bellis, D and Pacella, A},
title = {Closing the knowledge gap on the composition of the asbestos bodies.},
journal = {Environmental geochemistry and health},
volume = {45},
number = {7},
pages = {5039-5051},
pmid = {37058192},
issn = {1573-2983},
support = {BRIC2019, ID57//Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro/ ; },
mesh = {Humans ; *Asbestosis/etiology/pathology ; *Asbestos/toxicity/analysis ; Lung/chemistry ; },
abstract = {Asbestos bodies (AB) form in the lungs as a result of a biomineralization process initiated by the alveolar macrophages in the attempt to remove asbestos. During this process, organic and inorganic material deposit on the foreign fibers forming a Fe-rich coating. The AB start to form in months, thus quickly becoming the actual interface between asbestos and the lung tissue. Therefore, revealing their composition, and, in particular, the chemical form of Fe, which is the major component of the AB, is essential to assess their possible role in the pathogenesis of asbestos-related diseases. In this work we report the result of the first x-ray diffraction measurements performed on single AB embedded in the lung tissue samples of former asbestos plant workers. The combination with x-ray absorption spectroscopy data allowed to unambiguously reveal that Fe is present in the AB in the form of two Fe-oxy(hydroxides): ferrihydrite and goethite. The presence of goethite, which can be explained in terms of the transformation of ferrihydrite (a metastable phase) due to the acidic conditions induced by the alveolar macrophages in their attempt to phagocytose the fibers, has toxicological implications that are discussed in the paper.},
}
@article {pmid37057081,
year = {2023},
author = {Sundaralingam, A and Aujayeb, A and Jackson, KA and Pellas, EI and Khan, II and Chohan, MT and Joosten, R and Boersma, A and Kerkhoff, J and Bielsa, S and Porcel, JM and Rozman, A and Marc-Malovrh, M and Welch, H and Symonds, J and Anevlavis, S and Froudrakis, M and Mei, F and Zuccatosta, L and Gasparini, S and Gonnelli, F and Dhaliwal, I and Mitchell, MA and Fjaellegaard, K and Petersen, JK and Ellayeh, M and Rahman, NM and Burden, T and Bodtger, U and Koegelenberg, CFN and Maskell, NA and Janssen, J and Bhatnagar, R},
title = {Investigation and outcomes in patients with nonspecific pleuritis: results from the International Collaborative Effusion database.},
journal = {ERJ open research},
volume = {9},
number = {2},
pages = {},
pmid = {37057081},
issn = {2312-0541},
abstract = {INTRODUCTION: We present findings from the International Collaborative Effusion database, a European Respiratory Society clinical research collaboration. Nonspecific pleuritis (NSP) is a broad term that describes chronic pleural inflammation. Various aetiologies lead to NSP, which poses a diagnostic challenge for clinicians. A significant proportion of patients with this finding eventually develop a malignant diagnosis.<br><br>METHODS: 12 sites across nine countries contributed anonymised data on 187 patients. 175 records were suitable for analysis.<br><br>RESULTS: The commonest aetiology for NSP was recorded as idiopathic (80 out of 175, 44%). This was followed by pleural infection (15%), benign asbestos disease (12%), malignancy (6%) and cardiac failure (6%). The malignant diagnoses were predominantly mesothelioma (six out of 175, 3.4%) and lung adenocarcinoma (four out of 175, 2.3%). The median time to malignant diagnosis was 12.2&#x2005;months (range 0.8-32 months). There was a signal towards greater asbestos exposure in the malignant NSP group compared to the benign group (0.63 versus 0.27, p=0.07). Neither recurrence of effusion requiring further therapeutic intervention nor initial biopsy approach were associated with a false-negative biopsy. A computed tomography finding of a mass lesion was the only imaging feature to demonstrate a significant association (0.18 versus 0.01, p=0.02), although sonographic pleural thickening also suggested an association (0.27 versus 0.09, p=0.09).<br><br>DISCUSSION: This is the first multicentre study of NSP and its associated outcomes. While some of our findings are reflected by the established body of literature, other findings have highlighted important areas for future research, not previously studied in NSP.},
}
@article {pmid37047661,
year = {2023},
author = {Boumya, S and Fallarini, S and Siragusa, S and Petrarolo, G and Aprile, S and Audrito, V and La Motta, C and Garavaglia, S and Moro, L and Pinton, G},
title = {A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment.},
journal = {International journal of molecular sciences},
volume = {24},
number = {7},
pages = {},
pmid = {37047661},
issn = {1422-0067},
support = {FAR#2019//University of Eastern Piedmont Amadeo Avogadro/ ; MFAG-2021 #26004 to V.A.//Associazione Italiana di Ricerca sul Cancro/ ; },
mesh = {Humans ; Aldehyde Dehydrogenase ; Cell Line, Tumor ; Enzyme Inhibitors/therapeutic use ; *Lung Neoplasms/genetics ; *Mesothelioma/drug therapy/genetics/metabolism ; *Mesothelioma, Malignant ; Neutrophil Infiltration ; *Pleural Neoplasms/pathology ; Spheroids, Cellular/metabolism ; Tumor Microenvironment ; Retinal Dehydrogenase/metabolism ; },
abstract = {Aldehyde dehydrogenase 1A3 (ALDH1A3), one of the three members of the aldehyde dehydrogenase 1A subfamily, has been associated with increased progression and drug resistance in various types of solid tumours. Recently, it has been reported that high ALDH1A3 expression is prognostic of poor survival in patients with malignant pleural mesothelioma (MPM), an asbestos-associated chemoresistant cancer. We treated MPM cells, cultured as multicellular spheroids, with NR6, a potent and highly selective ALDH1A3 inhibitor. Here we report that NR6 treatment caused the accumulation of toxic aldehydes, induced DNA damage, CDKN2A expression and cell growth arrest. We observed that, in CDKN2A proficient cells, NR6 treatment induced IL6 expression, but abolished CXCL8 expression and IL-8 release, preventing both neutrophil recruitment and generation of neutrophil extracellular traps (NETs). Furthermore, we demonstrate that in response to ALDH1A3 inhibition, CDKN2A loss skewed cell fate from senescence to apoptosis. Dissecting the role of ALDH1A3 isoform in MPM cells and tumour microenvironment can open new fronts in the treatment of this cancer.},
}
@article {pmid37047331,
year = {2023},
author = {Hager, T and Borchert, S and Wessolly, M and Mathilakathu, A and Mairinger, E and Kollmeier, J and Mairinger, T and Hegedus, B and Greimelmaier, K and Wohlschlaeger, J and Herrmann, K and Mairinger, FD},
title = {One Third of Malignant Pleural Mesothelioma Shows High Immunohistochemical Expression of MSLN or CXCR4 Which Indicates Potent Candidates for Endo-Radiotherapy.},
journal = {International journal of molecular sciences},
volume = {24},
number = {7},
pages = {},
pmid = {37047331},
issn = {1422-0067},
mesh = {Humans ; *Mesothelioma, Malignant ; Mesothelin ; *Mesothelioma/drug therapy/radiotherapy/diagnosis ; Positron Emission Tomography Computed Tomography ; GPI-Linked Proteins/genetics/metabolism ; *Pleural Neoplasms/metabolism ; *Lung Neoplasms/metabolism ; Receptors, CXCR4/genetics ; },
abstract = {Malignant pleural mesothelioma (MPM) is a mainly asbestos-related tumour associated with a very poor prognosis. Therapeutic approaches include multimodal therapy and chemotherapeutics, with cisplatin being the drug of choice, but response rates of only up to 14% indicate very poor outcomes. Effective treatment options are lacking. Besides the diagnostic usage of radioligands in positron emission tomography (PET)/computed tomography (CT), the endo-radioligand therapy with Lu177 has been proven as a powerful tool in cancer therapy. Mesothelin (MSLN) and C-XC chemokine receptor 4 (CXCR4) are membrane-bound proteins, expressed in certain cancers, and thus are promising targets for endo-radiotherapy. A significant portion of high MSLN- or CXCR4-expressing tumors within the MPM may open the field for this sophisticated treatment approach in the near future. Formalin-fixed, paraffin-embedded (FFPE) tumour specimens from 105 patients suffering from MPM and treated at the Lung Cancer Centre of Essen and at the Helios Klinikum Emil von Behring Berlin were screened. The tumour samples were arranged in tissue microarrays. We immunohistochemically stained the tumour samples against MSLN and CXCR4. The protein expressions of the stainings were scored by a pathologist by using a semiquantitative method. The data obtained were correlated with the clinical outcome. Overall, 77.1% of the analysed tumours showed CXCR4 protein expression (25.7% of them at high expression level (Score 3)). 48.6% of all samples showed an overall strong staining (Score ≥ 2), 59% of the investigated tumours showed MSLN protein expression (10.5% of them at high expression (Score 3)), and 36.2% of all samples showed an overall strong staining (Score ≥ 2). Our results show significant tissue expression levels, for both CXCR4 and MSLN protein, in a major portion of clinical MPM samples. One-third of patients showed outstanding immunoexpression of at least one of these markers, making them interesting candidates for radioligand-based PET/CT diagnostics and follow-up and furthermore may profit from endo-radiotherapy.},
}
@article {pmid37040900,
year = {2023},
author = {Chu, GJ and Linton, A and Kao, S and Klebe, S and Adelstein, S and Yeo, D and Rasko, JEJ and Cooper, WA},
title = {High mesothelin expression by immunohistochemistry predicts improved survival in pleural mesothelioma.},
journal = {Histopathology},
volume = {83},
number = {2},
pages = {202-210},
pmid = {37040900},
issn = {1365-2559},
support = {//CSR Ltd/ ; //Li Ka Shing Foundation/ ; //Royal College of Pathologists of Australasia/ ; //Sydney Local Health District/ ; PW18-030//Cancer Council of NSW/ ; RG20-07//Cancer Council of NSW/ ; APP1169460//National Health and Medical Research Council/ ; 1177305//National Health and Medical Research Council/ ; },
mesh = {Humans ; GPI-Linked Proteins/metabolism ; Immunohistochemistry ; *Mesothelioma/pathology ; *Mesothelioma, Malignant ; *Pleural Neoplasms/pathology ; *Receptors, Chimeric Antigen ; },
abstract = {AIMS: Mesothelin (MSLN) is a cancer-associated antigen that is overexpressed in malignancies such as mesothelioma, pancreatic and ovarian cancer. It is also a target for novel personalised therapies, including antibodies, antibody-drug conjugates and chimeric antigen receptor T cells. Immunohistochemistry may predict those who would best respond to anti-mesothelin therapies and guide decisions in therapeutic strategy. This study aimed to assess the intensity and distribution of MSLN immunostaining in mesothelioma, and to determine the prognostic value of MSLN expression by histochemical-score (H-score).<br><br>METHODS AND RESULTS: The MN1 anti-MSLN antibody was used to stain a formalin-fixed paraffin-embedded tissue microarray of histologically confirmed mesothelioma from 75 consecutive patients who had undergone pleurectomy with or without decortication. MSLN positivity, the staining intensity, distribution of staining and H-score were evaluated. The correlation of H-score with prognosis was investigated. Sixty-six per cent of epithelioid tumours were MSLN-positive (with expression in >&#x2009;5% tumour cells). Of MSLN-expressing epithelioid tumours, 70.4% had moderate (2+) or strong (3+) intensity MSLN immunostaining, although only 37% of samples had staining in &#x2265;&#x2009;50% of tumour cells. In multivariate analysis, MSLN H-score as a continuous variable and an H-score&#x2009;&#x2265;&#x2009;33 were independent predictors of improved survival (P&#x2009;=&#x2009;0.04 and P&#x2009;<&#x2009;0.001, respectively).<br><br>CONCLUSIONS: MSLN expression was more heterogenous in epithelioid mesothelioma than reported previously. Therefore, it would be appropriate to perform an immunohistochemical assessment of MSLN expression to stratify and assess patient suitability for mesothelin-targeted personalised therapies, such as chimeric antigen receptor T cells.},
}
@article {pmid37027032,
year = {2023},
author = {Akarsu, M and Ak, G and Dündar, E and Metintaş, M},
title = {Genetic analysis of familial predisposition in the pathogenesis of malignant pleural mesothelioma.},
journal = {Journal of cancer research and clinical oncology},
volume = {149},
number = {10},
pages = {7767-7778},
pmid = {37027032},
issn = {1432-1335},
mesh = {Humans ; *Mesothelioma, Malignant ; Genetic Predisposition to Disease ; *Lung Neoplasms/pathology ; *Mesothelioma/genetics/pathology ; *Asbestos/toxicity ; *Pleural Neoplasms/genetics/pathology ; },
abstract = {PURPOSE: Mesothelioma is the primary tumor of the mesothelial cell membrane. The most important etiology is asbestos exposure. The development of malignant mesothelioma in very few of the population exposed to asbestos and its frequent occurrence in some families may be significant in terms of genetic predisposition. Again, the presence of relatives with mesothelioma who did not have asbestos contact strengthens this argument. This disease, which has limited treatment options and has a poor prognosis, revealing a genetic predisposition, if any, may prolong survival with early diagnosis and effective treatment.<br><br>METHODS: Based on the genetic predisposition idea, we diagnosed and followed a total of ten individuals of relatives with mesothelioma. DNA was isolated from peripheral blood and whole genome sequencing analysis was done. Common gene mutations in ten individuals were filtered using bioinformatics. After this filter, from the remaining variants, very rare in the population and damaging mutations are selected.<br><br>RESULTS: Eight thousand six hundred and twenty-two common variants have been identified in ten individuals with this analysis. In total, 120 variants were found on 37 genes in 15 chromosomes. These genes are PIK3R4, SLC25A5, ITGB6, PLK2, RAD17, HLA-B, HLA-DRB1, HLA-DQB1, GRM, IL20RA, MAP3K7, RIPK2, and MUC16.<br><br>CONCLUSION: Our finding, PIK3R4 gene, is directly associated with mesothelioma development. Twelve genes, which are associated with cancer, were detected in literature. Additional studies, which scan first-degree relatives of individual, are needed to find the specific gene region.},
}
@article {pmid37010194,
year = {2023},
author = {Kitamura, Y and Zha, L and Liu, R and Shima, M and Nakaya, T and Kurumatani, N and Kumagai, S and Goji, J and Sobue, T},
title = {Association of mesothelioma deaths with neighborhood asbestos exposure due to a large-scale asbestos-cement plant.},
journal = {Cancer science},
volume = {114},
number = {7},
pages = {2973-2985},
pmid = {37010194},
issn = {1349-7006},
support = {15H04774//Japan Society for the Promotion of Science/ ; },
mesh = {Male ; Female ; Humans ; Case-Control Studies ; Environmental Exposure/adverse effects ; *Mesothelioma/chemically induced/epidemiology ; *Asbestos/toxicity ; *Mesothelioma, Malignant/chemically induced ; *Pleural Neoplasms/epidemiology ; },
abstract = {A causal relationship between mesothelioma and occupational asbestos exposure is well known, while some studies have shown a relationship to non-occupational exposures. The aim of this study was to quantify the risk of mesothelioma death associated with neighborhood asbestos exposure due to a large-scale asbestos-cement (AC) plant in Amagasaki, Japan, adjusting properly risk factors including occupational exposures. We conducted a nested case-control study in which a fixed population of 143,929 residents who had been living in Amagasaki City between 1975 and 2002 were followed from 2002 to 2015. All 133 cases and 403 matched controls were interviewed about their occupational, domestic, household, and neighborhood asbestos exposures. Odds ratios (ORs) for mesothelioma death associated with the neighborhood exposure were estimated by a conditional logistic-regression model. For quantitative assessments for neighborhood exposure, we adopted cumulative indices for individuals' residential histories at each residence-specific asbestos concentration multiplied by the duration during the potential exposure period of 1957-1975 (crocidolite). We observed an increasing, dose-dependent risk of mesothelioma death associated with neighborhood exposure, demonstrating that ORs in the highest quintile category were 21.4 (95% confidence interval [CI] 5.8-79.2) for all, 23.7 (95% CI 3.8-147.2) for males, and 26.0 (95% CI 2.8-237.5) for females compared to the lowest quintile, respectively. A quantitative assessment for risk of mesothelioma deaths, adjusting for occupational and non-occupational exposures separately, showed a dose-dependent association with neighborhood exposure and no substantial gender differences in magnitude.},
}
@article {pmid36981857,
year = {2023},
author = {Gaitens, JM and Culligan, M and Friedberg, JS and Glass, E and Reback, M and Scilla, KA and Sachdeva, A and Atalla, A and McDiarmid, MA},
title = {Laying the Foundation for a Mesothelioma Patient Registry: Development of Data Collection Tools.},
journal = {International journal of environmental research and public health},
volume = {20},
number = {6},
pages = {},
pmid = {36981857},
issn = {1660-4601},
support = {U24 OH009077/OH/NIOSH CDC HHS/United States ; 75D30119P05558/CC/CDC HHS/United States ; },
mesh = {United States/epidemiology ; Humans ; *Mesothelioma/chemically induced ; *Mesothelioma, Malignant ; *Asbestos/toxicity ; *Occupational Exposure/adverse effects ; Registries ; Surveys and Questionnaires ; Incidence ; },
abstract = {Mesothelioma, a cancer of mesothelial cells that line the chest, lungs, heart, and abdomen, is a relatively rare disease. In the United States, approximately 3000 individuals are diagnosed with mesothelioma annually. The primary risk factor for mesothelioma is occupational asbestos exposure which can occur decades prior to disease development, though in approximately 20% of cases, known asbestos exposure is lacking. While several other countries have developed mesothelioma registries to collect key clinical and exposure data elements to allow better estimation of incidence, prevalence, and risk factors associated with disease development, no national mesothelioma registry exists in the U.S. Therefore, as part of a larger feasibility study, a patient exposure questionnaire and a clinical data collection tool were created using a series of key informant interviews. Findings suggest that risk factor and clinical data collection via an on-line questionnaire is feasible, but specific concerns related to confidentiality, in the context of employer responsibility for exposure in the unique U.S. legal environment, and timing of enrollment must be addressed. Lessons learned from piloting these tools will inform the design and implementation of a mesothelioma registry of national scope.},
}
@article {pmid36981000,
year = {2023},
author = {Doyle, E and Blanchon, D and Wells, S and de Lange, P and Lockhart, P and Waipara, N and Manefield, M and Wallis, S and Berry, TA},
title = {Internal Transcribed Spacer and 16S Amplicon Sequencing Identifies Microbial Species Associated with Asbestos in New Zealand.},
journal = {Genes},
volume = {14},
number = {3},
pages = {},
pmid = {36981000},
issn = {2073-4425},
mesh = {*Siderophores ; New Zealand ; *Asbestos ; Iron/metabolism ; Bacteria/genetics/metabolism ; Soil ; },
abstract = {Inhalation of asbestos fibres can cause lung inflammation and the later development of asbestosis, lung cancer, and mesothelioma, and the use of asbestos is banned in many countries. In most countries, large amounts of asbestos exists within building stock, buried in landfills, and in contaminated soil. Mechanical, thermal, and chemical treatment options do exist, but these are expensive, and they are not effective for contaminated soil, where only small numbers of asbestos fibres may be present in a large volume of soil. Research has been underway for the last 20 years into the potential use of microbial action to remove iron and other metal cations from the surface of asbestos fibres to reduce their toxicity. To access sufficient iron for metabolism, many bacteria and fungi produce organic acids, or iron-chelating siderophores, and in a growing number of experiments these have been found to degrade asbestos fibres in vitro. This paper uses the internal transcribed spacer (ITS) and 16S amplicon sequencing to investigate the fungal and bacterial diversity found on naturally-occurring asbestos minerals, asbestos-containing building materials, and asbestos-contaminated soils with a view to later selectively culturing promising species, screening them for siderophore production, and testing them with asbestos fibres in vitro. After filtering, 895 ITS and 1265 16S amplicon sequencing variants (ASVs) were detected across the 38 samples, corresponding to a range of fungal, bacteria, cyanobacterial, and lichenized fungal species. Samples from Auckland (North Island, New Zealand) asbestos cement, Auckland asbestos-contaminated soils, and raw asbestos rocks from Kahurangi National Park (South Island, New Zealand) were comprised of very different microbial communities. Five of the fungal species detected in this study are known to produce siderophores.},
}
@article {pmid36980631,
year = {2023},
author = {Mensi, C and Stella, S and Dallari, B and Rugarli, S and Pesatori, AC and Ceresoli, GL and Consonni, D},
title = {Second Primary Cancers in a Population-Based Mesothelioma Registry.},
journal = {Cancers},
volume = {15},
number = {6},
pages = {},
pmid = {36980631},
issn = {2072-6694},
support = {BRiC 55/2019//Istituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro/ ; },
abstract = {BACKGROUND: The presence of a second primary cancer (SPC) in patients with pleural mesothelioma (PM) may impact overall survival and suggest a common mechanism of carcinogenesis or an underlying germline genetic alteration.<br><br>METHODS: We evaluated the occurrence of SPCs within PM cases collected from 2000 to 2018 by the Lombardy Mesothelioma Registry and their prognostic implications. Kaplan-Meier analysis was performed to estimate median survival times, together with univariate and multivariate Cox regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) of death.<br><br>RESULTS: The median overall survival (OS) of the entire study population (N = 6646) was 10.9 months (95% CI: 10.4-11.2); patient age and histotype were the strongest prognostic factors. No substantial survival difference was observed by the presence of an SPC (10.5 months in 1000 patients with an SPC vs. 10.9 months in 5646 patients in the non-SPC group, HR 1.03, p = 0.40). Shorter OS in the SPC group was only observed in 150 patients with the non-epithelioid subtype (median OS of 5.4 vs. 7.1 months, HR 1.21, p = 0.03).<br><br>CONCLUSIONS: The diagnosis of an SPC did not influence the outcome of PM patients in the overall study population but was associated with shorter OS in non-epithelioid cases. Further studies are needed to clarify the role of SPCs as markers of genetic susceptibility in mesothelioma.},
}
@article {pmid36974955,
year = {2023},
author = {Dement, JM and Loomis, D},
title = {Manufactured doubt and the EPA 2020 chrysotile asbestos risk assessment.},
journal = {American journal of industrial medicine},
volume = {66},
number = {7},
pages = {543-553},
doi = {10.1002/ajim.23476},
pmid = {36974955},
issn = {1097-0274},
mesh = {United States ; Humans ; Asbestos, Serpentine/toxicity/analysis ; United States Environmental Protection Agency ; *Lung Neoplasms ; *Asbestos/toxicity/analysis ; Asbestos, Amphibole/toxicity/analysis ; Asbestos, Crocidolite/analysis/toxicity ; Risk Assessment ; *Mesothelioma/epidemiology ; },
abstract = {While all forms of asbestos have been determined to be carcinogenic to humans by the International Agency for Research on Cancer (IARC) as well as other authoritative bodies, the relative carcinogenic potency of chrysotile continues to be argued, largely in the context of toxic tort litigation. Relatively few epidemiologic studies have investigated only a single form of asbestos; however, one study that included an asbestos textile plant located in Marshville, North Carolina that processed chrysotile asbestos was used by the United States Environmental Protection Agency (EPA) in 2020 to help inform the agency's chrysotile asbestos risk assessment. During the EPA proceedings toxic tort defense consultants submitted comments to the EPA docket and made public presentations asserting that the Marshville plant had processed amphibole asbestos types and should not be used for the chrysotile risk assessment. A detailed evaluation of defense consultant assertions and supporting information and a full assessment of the available information concerning asbestos types used at the Marshville plant was undertaken. The preponderance of evidence continues to support the conclusion that neither amosite nor crocidolite were likely to have been processed in the Marshville textile plant. Defense consultants' assertions about chrysotile use are not supported by the preponderance of evidence and constitute an example of manipulation of information to cast uncertainty and doubt rather than to seek truth and contribute to the body of scientific evidence.},
}
@article {pmid36966347,
year = {2023},
author = {Marcu, A and McGregor, F and Egan, B and Hill, K and Cook, T and Arber, A},
title = {Developing sustainable patient and public involvement in mesothelioma research: multi-method exploration with researchers, patients, carers, and patient organisations.},
journal = {Research involvement and engagement},
volume = {9},
number = {1},
pages = {15},
pmid = {36966347},
issn = {2056-7529},
support = {JH-18-10//June Hancock Mesothelioma Research Fund/ ; JH-18-10//June Hancock Mesothelioma Research Fund/ ; JH-18-10//June Hancock Mesothelioma Research Fund/ ; JH-18-10//June Hancock Mesothelioma Research Fund/ ; },
abstract = {BACKGROUND: Rare diseases where prognosis is poor provide limited scope for patient and public involvement (PPI). One such disease is mesothelioma, a cancer of the lung pleura or of the peritoneum caused by exposure to asbestos, where PPI is poorly documented. We undertook to explore how PPI could be facilitated in mesothelioma research.<br><br>METHODS: An online survey with mesothelioma researchers (n&#x2009;=&#x2009;23) assessed the perceived benefits and challenges of PPI in mesothelioma. Six online workshops and thirteen in-depth interviews with patients and the public explored their views on how PPI could be increased in mesothelioma and their motivations to become PPI representatives in the future. The survey data were analysed using descriptive statistics and the interviews, using Thematic Analysis.<br><br>RESULTS: In the survey, 26% (n&#x2009;=&#x2009;6) of the researchers did not include PPI in their research, while 74% (n&#x2009;=&#x2009;17) did, finding it most beneficial at the stages of applying for funding and dissemination. The main perceived benefits of PPI were clarifying the research question and outcome measures, making research more credible and relevant to patients' needs, and increasing its impact. The main perceived challenges to PPI were the general poor prognosis in mesothelioma, and funding timescales which hindered timely recruitment of PPI representatives. The analysis of the interviews with the patients and public revealed three main themes: "Motivations to become a PPI representative in the future", "Understanding the nature of PPI during the project", and "Perceived challenges to PPI in mesothelioma". Altruism and the need for hope were the main reasons to wish to become involved in PPI in the future. For many participants, the project proved to be a journey of understanding the nature of PPI, a concept that was not easy to grasp from the start. The participants perceived certain barriers to PPI such as high symptom burden in mesothelioma, the abstract concept of PPI, and the use of scientific language.<br><br>CONCLUSIONS: The present research provides a detailed picture of the benefits and challenges of PPI in mesothelioma. We recommend long-term engagement with mesothelioma support groups so that researchers achieve meaningful and sustainable PPI in mesothelioma research.},
}
@article {pmid36965810,
year = {2023},
author = {Gao, Y and Mazurek, JM and Li, Y and Blackley, D and Weissman, DN and Burton, SV and Amin, W and Landsittel, D and Becich, MJ and Ye, Y},
title = {Industry, occupation, and exposure history of mesothelioma patients in the U.S. National Mesothelioma Virtual Bank, 2006-2022.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {115085},
pmid = {36965810},
issn = {1096-0953},
support = {CC999999/ImCDC/Intramural CDC HHS/United States ; U24 OH009077/OH/NIOSH CDC HHS/United States ; U24OH009077/ACL/ACL HHS/United States ; },
mesh = {Female ; Humans ; Male ; *Mesothelioma, Malignant/chemically induced ; *Mesothelioma/chemically induced/epidemiology ; *Asbestos/toxicity ; Industry ; Occupations ; *Occupational Exposure/adverse effects ; *Occupational Diseases/epidemiology ; },
abstract = {BACKGROUND: Malignant mesothelioma is associated with environmental and occupational exposure to certain mineral fibers, especially asbestos. This study aims to examine work histories of mesothelioma patients and their survival time.<br><br>METHOD: Using the NIOSH Industry and Occupation Computerized Coding System, we mapped occupations and industries recorded for 748 of 1444 patients in the U.S. National Mesothelioma Virtual Bank (NMVB) during the period 2006-2022. Descriptive and survival analyses were conducted.<br><br>RESULTS: Among the 1023 industries recorded for those having mesothelioma, the most frequent cases were found for those in manufacturing (n&#xa0;=&#xa0;225, 22.0%), construction (138, 13.5%), and education services (66, 6.5%); among the 924 occupation records, the most frequent cases were found for those in construction and extraction (174, 18.8%), production (145, 15.7%), and management (84, 9.1%). Males (583) or persons aged >40 years (658) at the time of diagnosis tended to have worked in industries traditionally associated with mesothelioma (e.g., construction), while females (163) or persons aged 20-40 years (27) tended to have worked in industries not traditionally associated with mesothelioma (e.g., health care). Asbestos, unknown substances, and chemical solvents were the most frequently reported exposure, with females most often reporting an unknown substance. A multi-variable Cox Hazard Regression analysis showed that significant prognostic factors associated with decreased survival in mesothelioma cases are sex (male) and work experience in utility-related industry, while factor associated with increased survival are epithelial or epithelioid histological type, prior history of surgery and immunotherapy, and industry experience in accommodation and food services.<br><br>CONCLUSION: The NMVB has the potential of serving as a sentinel surveillance mechanism for identifying industries and occupations not traditionally associated with mesothelioma. Results indicate the importance of considering all potential sources of asbestos exposures including occupational, environmental, and extra-occupational exposures when evaluating mesothelioma patients and advising family members.},
}
@article {pmid36965809,
year = {2023},
author = {Lieberman-Cribbin, W and Taioli, E},
title = {Epidemiologic roadblocks in studying elongated mineral particles and mesothelioma risk.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {115086},
doi = {10.1016/j.envres.2022.115086},
pmid = {36965809},
issn = {1096-0953},
mesh = {Humans ; Silicates ; Iron ; *Occupational Exposure/adverse effects/analysis ; *Air Pollutants, Occupational/analysis ; *Lung Neoplasms/chemically induced/epidemiology ; Minerals/analysis ; *Mesothelioma/chemically induced/epidemiology ; *Asbestos/toxicity ; },
abstract = {Elongated mineral particles (EMPs) are a type of both occupational and environmental exposures that have generated interest in the scientific community due to their potential health effects. Their possible association with mesothelioma represents an area of concern. We provide an overview of the current challenges around epidemiological assessments of EMP exposure and mesothelioma risk, including methodological aspects that need to be addressed when designing and analyzing a study on EMP exposure and mesothelioma. Future work is needed to investigate the relationship between EMPs and mesothelioma, focused on an improved definition of EMP exposure and accounting for other concomitant sources of carcinogen exposure.},
}
@article {pmid36965808,
year = {2023},
author = {Bogen, KT},
title = {Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {115047},
doi = {10.1016/j.envres.2022.115047},
pmid = {36965808},
issn = {1096-0953},
mesh = {Animals ; Humans ; *Asbestos/toxicity ; *Mesothelioma/chemically induced/genetics ; Inflammation/chemically induced/metabolism ; *Lung Neoplasms/chemically induced/genetics ; *Carcinogens, Environmental/toxicity ; Mutation ; },
abstract = {Alterations in complex cellular phenotype each typically involve multistep activation of an ultrasensitive molecular switch (e.g., to adaptively initiate an apoptosis, inflammasome, Nrf2-ARE anti-oxidant, or heat-shock activation pathway) that triggers expression of a suite of target genes while efficiently limiting false-positive switching from a baseline state. Such switches exhibit nonlinear signal-activation relationships. In contrast, a linear no-threshold (LNT) dose-response relationship is expected for damage that accumulates in proportion to dose, as hypothesized for increased risk of cancer in relation to genotoxic dose according to the multistage somatic mutation/clonal-expansion theory of cancer, e.g., as represented in the Moolgavkar-Venzon-Knudsen (MVK) cancer model by a doubly stochastic nonhomogeneous Poisson process. Mesothelioma and lung cancer induced by exposure to carcinogenic (e.g., certain asbestos) fibers in humans and experimental animals are thought to involve modes of action driven by mutations, cytotoxicity-associated inflammation, or both, rendering ambiguous expectations concerning the nature of model-implied shape of the low-dose response for above-background increase in risk of incurring these endpoints. A recent Inflammation Somatic Mutation (ISM) theory of cancer posits instead that tissue-damage-associated inflammation that epigenetically recruits, activates and orchestrates stem cells to engage in tissue repair does not merely promote cancer, but rather is a requisite co-initiator (acting together with as few as two somatic mutations) of the most efficient pathway to any type of cancer in any reparable tissue (Dose-Response 2019; 17(2):1-12). This theory is reviewed, implications of this theory are discussed in relation to mesothelioma and lung cancer associated with chronic asbestos inhalation, one of the two types of ISM-required mutations is here hypothesized to block or impede inflammation resolution (e.g., by doing so for GPCR-mediated signal transduction by one or more endogenous autacoid specialized pro-resolving mediators or SPMs), and supporting evidence for this hypothesis is discussed.},
}
@article {pmid36965804,
year = {2023},
author = {Sanchez, MS and McGrath-Koerner, M and McNamee, BD},
title = {Characterization of elongate mineral particles including talc, amphiboles, and biopyriboles observed in mineral derived powders: Comparisons of analysis of the same talcum powder samples by two laboratories.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {114791},
doi = {10.1016/j.envres.2022.114791},
pmid = {36965804},
issn = {1096-0953},
mesh = {*Asbestos, Amphibole/toxicity ; Talc/toxicity ; Powders ; Laboratories ; Minerals/toxicity ; *Asbestos ; },
abstract = {Elongate mineral particles, including asbestos, have long been screened in talc and other mineral powders. In recent years, there has been a renewed scrutiny of talc containing asbestos due to allegations in civil litigation in the United States as well as reports, proposals, and white papers by international laboratories and government bodies related to this subject. This study demonstrates the importance of the fundamental understanding of both mineralogy and its application, using microscopy with empirical examples from conflicting analyses of the same talc powders by two independent laboratories in civil litigation in the United States. Methods include polarized light microscopy (PLM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) in the accurate measurement of morphological, optical, compositional, and structural data to characterize mineral-based samples. Discussions in this study include: 1) contrasting the interlaboratory findings of amphibole and amphibole asbestos by PLM and TEM using various preparation techniques, 2) the use of multiple analytical tools on a singular particle for identification, 3) the misidentification of anthophyllite asbestos by inexpert use of electron diffraction using TEM, and 4) the misidentification of chrysotile in talc by PLM. These examples emphasize the importance of not only maintaining the existing requirements, but of the need for even more rigorous analytical requirements in routine monitoring of elongate mineral particles that may occur in mineral-based powders.},
}
@article {pmid36965802,
year = {2023},
author = {Darnton, L},
title = {Quantitative assessment of mesothelioma and lung cancer risk based on Phase Contrast Microscopy (PCM) estimates of fibre exposure: an update of 2000 asbestos cohort data.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {114753},
doi = {10.1016/j.envres.2022.114753},
pmid = {36965802},
issn = {1096-0953},
mesh = {Humans ; Asbestos, Serpentine/toxicity ; Asbestos, Amosite ; Asbestos, Crocidolite/toxicity ; Microscopy, Phase-Contrast ; *Occupational Exposure ; *Asbestos/toxicity ; *Mesothelioma/chemically induced/epidemiology ; *Lung Neoplasms/chemically induced/epidemiology ; Asbestos, Amphibole/toxicity ; *Occupational Diseases ; },
abstract = {An earlier meta-analysis of mortality studies of asbestos-exposed worker populations, quantified excess mesothelioma and lung cancer risks in relation to cumulative exposure to the three main commercial asbestos types. The aim of this paper was to update these analyses incorporating new data based on increased follow-up of studies previously included, as well as studies of worker populations exposed predominantly to single fibre types published since the original analysis. Mesothelioma as a percentage of expected mortality due to all causes of death, percentage excess lung cancer and mean cumulative exposure were abstracted from available mortality studies of workers exposed predominantly to single asbestos types. Average excess mesothelioma and lung cancer per unit of cumulative exposure were summarised for groupings of studies by fibre type; models for pleural and peritoneal mesothelioma risk and lung cancer risk in terms of cumulative exposure for the different fibre types were fitted using Poisson regression. The average mesothelioma risks (per cent of total expected mortality) per unit cumulative exposure (f/cc.yr), RM, were 0.51 for crocidolite, 0.12 for amosite, and 0.03 for the Libby mixed amphiboles cohort. Significant heterogeneity was present for cohorts classed as chrysotile, with RM values of 0.01 for chrysotile textiles cohorts and 0.0011 for other chrysotile-exposed cohorts. Average percentage excess lung cancer risks per unit cumulative exposure, RL, were 4.3 for crocidolite and amosite combined, 0.82 for Libby. Very significant heterogeneity was present for chrysotile-exposed cohorts with RL values spanning two orders of magnitude from 0.053 for the Balangero mine to 4.8 for the South Carolina textiles cohort. Best fitting models suggest a non-linear exposure-response in which the peritoneal mesothelioma risk is proportional to approximately the square of cumulative exposure. Pleural mesothelioma and lung cancer risk were proportion to powers of cumulative exposure slightly less than one and slightly higher than one respectively.},
}
@article {pmid36965801,
year = {2023},
author = {Nel, A},
title = {Carbon nanotube pathogenicity conforms to a unified theory for mesothelioma causation by elongate materials and fibers.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {114580},
doi = {10.1016/j.envres.2022.114580},
pmid = {36965801},
issn = {1096-0953},
mesh = {Humans ; *Nanotubes, Carbon/toxicity ; Virulence ; *Mesothelioma/chemically induced ; *Asbestos/toxicity ; Inflammation/pathology ; },
abstract = {The purpose of this review is to elucidate how dimensional and durability characteristics of high aspect ratio nanomaterials (HARN), including carbon nanotubes (CNT) and metal nanowires (MeNW), contribute to understanding the fiber pathogenicity paradigm (FPP), including by explaining the structure-activity relationships (SAR) of a diverse range of natural and synthetic elongate materials that may or may not contribute to mesothelioma development in the lung. While the FPP was originally developed to explain the critical importance of asbestos and synthetic vitreous fiber length, width, aspect ratio and biopersistence in mesothelioma development, there are a vast number of additional inhalable materials that need to be considered in terms of pathogenic features that may contribute to mesothelioma or lack thereof. Not only does the ability to exert more exact control over the length and biopersistence of HARNs confirm the tenets of the FPP, but could be studied by implementating more appropriate toxicological tools for SAR analysis. This includes experimentation with carefully assembled libraries of CNTs and MeNWs, helping to establish more precise dimensional features for interfering in lymphatic drainage from the parietal pleura, triggering of lysosomal damage, frustrated phagocytosis and generation of chronic inflammation. The evidence includes data that long and rigid, but not short and flexible multi-wall CNTs are capable of generating mesotheliomas in rodents based on an adverse outcome pathway requiring access to pleural cavity, obstruction of pleural stomata, chronic inflammation and transformation of mesothelial cells. In addition to durability and dimensional characteristics, bending stiffness of CNTs is a critical factor in determining the shape and rigidity of pathogenic MWCNTs. While no evidence has been obtained in humans that CNT exposure leads to a mesothelioma outcome, it is important to monitor exposure levels and health effect impacts in workers to prevent adverse health outcomes in humans.},
}
@article {pmid36965800,
year = {2023},
author = {Roggl, VL and Green, CL and Liu, B and Carney, JM and Glass, CH and Pavlisko, EN},
title = {Chronological trends in the causation of malignant mesothelioma: Fiber burden analysis of 619 cases over four decades.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {114530},
pmid = {36965800},
issn = {1096-0953},
support = {UL1 TR002553/TR/NCATS NIH HHS/United States ; },
mesh = {Female ; Humans ; Male ; Asbestos/toxicity ; Asbestosis/etiology/complications ; Lung/pathology ; *Lung Neoplasms/chemically induced/epidemiology ; *Mesothelioma/chemically induced/epidemiology ; Mesothelioma, Malignant/complications/pathology ; *Occupational Exposure ; },
abstract = {Malignant mesothelioma is a relatively rare malignancy with a strong association with prior asbestos exposure. A percentage of cases is not related to asbestos, and fiber analysis of lung tissue is a useful methodology for identifying idiopathic or spontaneous cases. We have performed fiber analyses in more than 600 cases of mesothelioma over the past four decades and were interested in looking for trends in terms of fiber types and concentrations as well as percentages of cases not related to asbestos. Demographic information was also considered including patient age, gender, and tumor location (pleural vs. peritoneal). The histologic pattern of the tumor and the presence or absence of pleural plaques or asbestosis were noted. Fiber analysis was performed in 619 cases, using the sodium hypochlorite technique for digestion of lung tissue samples. Asbestos bodies were counted by light microscopy (LM) and coated and uncoated fibers by scanning electron microscopy (EM). The results were stratified over four decades. Trends that were observed included increasing patient age, increasing percentage of women, increasing percentage of peritoneal cases, and increasing percentage of epithelial histological type. There was a decreasing trend in the percentage of patients with concomitant asbestosis (p < 0.001). The percentage of cases with an elevated lung asbestos content decreased from 90.5% in the 1980s to 54.1% in the 2010s (p < 0.001). This trend also held when the analysis was limited to 490 cases of pleural mesothelioma in men (91.8% in the 1980s vs. 65.1% in the 2010s). There was a decrease in the median asbestos body count by LM from 1390 asbestos bodies per gram of wet lung in the 1980s to 38 AB/gm in the 2010s. Similar trends were observed for each of the asbestos fiber types as detected by EM. We conclude that there has been a progressive decrease in lung fiber content of mesothelioma patients during the past four decades, with an increasing percentage of cases not related to asbestos and an increase in median patient age.},
}
@article {pmid36965799,
year = {2023},
author = {Moolgavkar, S and Chang, ET and Luebeck, EG},
title = {Multistage carcinogenesis: Impact of age, genetic, and environmental factors on the incidence of malignant mesothelioma.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {114582},
doi = {10.1016/j.envres.2022.114582},
pmid = {36965799},
issn = {1096-0953},
mesh = {Humans ; *Mesothelioma, Malignant/complications ; Incidence ; *Carcinogens, Environmental/toxicity ; Syndrome ; *Lung Neoplasms/chemically induced/epidemiology ; Genetic Predisposition to Disease ; *Asbestos/toxicity ; Carcinogenesis/chemically induced/genetics ; },
abstract = {The current paradigm of carcinogenesis as a cellular evolutionary process driven by mutations of a few critical driver genes has immediate logical implications for the epidemiology of cancer. These include the impact of age on cancer risk, the role played by inherited tumor predisposition syndromes, and the interaction of genetics and environmental exposures on cancer risk. In this paper, we explore the following logical epidemiological consequences of carcinogenesis as a clonal process of mutation accumulation, with special emphasis on asbestos-related cancers, specifically malignant mesothelioma:1 All cancers, including mesothelioma, can and do occur spontaneously, i.e., in the absence of exposure to any environmental carcinogens. 2. Age is an important determinant of cancer risk, with or without exposure to environmental carcinogens. 3. Genetic tumor predisposition syndromes, such as the BAP1 syndrome, increase enormously the risk of cancer even in the absence of exposure to environmental carcinogens. We illustrate these concepts by applying a multistage clonal expansion model to U.S. Surveillance, Epidemiology, and End Results cancer registry data for pleural and peritoneal malignant mesotheliomas in 1975-2018.},
}
@article {pmid36965798,
year = {2023},
author = {Wylie, AG and Korchevskiy, AA},
title = {Dimensions of elongate mineral particles and cancer: A review.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {114688},
doi = {10.1016/j.envres.2022.114688},
pmid = {36965798},
issn = {1096-0953},
mesh = {Humans ; Mineral Fibers/toxicity ; Minerals/toxicity/analysis ; *Mesothelioma/chemically induced/epidemiology ; Asbestos, Amphibole ; *Lung Neoplasms/chemically induced/epidemiology ; Carcinogens/analysis ; Dust/analysis ; *Asbestos ; },
abstract = {CONTEXT: Based on a decade-long exploration, dimensions of elongate mineral particles are implicated as a pivotal component of their carcinogenic potency. This paper summarizes current understanding of the discovered relationships and their importance to the protection of public health.<br><br>OBJECTIVES: To demonstrate the relationships between cancer risk and dimensions (length, width, and other derivative characteristics) of mineral fibers by comparing the results and conclusions of previously published studies with newly published information.<br><br>METHODS: A database including 59 datasets comprising 341,949 records were utilized to characterize dimensions of elongate particles. The descriptive statistics, correlation and regression analysis, combined with Monte Carlo simulation, were used to select dimensional characteristics most relevant for mesothelioma and lung cancer risk prediction.<br><br>RESULTS: The highest correlation between mesothelioma potency factor and weight fraction of size categories is achieved for fibers with lengths >5.6&#xa0;&#x3bc;m and widths &#x2264;0.26&#xa0;&#x3bc;m (R&#xa0;=&#xa0;0.94, P&#xa0;<&#xa0;0.02); no statistically significant potency was found for lengths <5&#xa0;&#x3bc;m. These results are consistent with early published estimations, though are derived from a different approach. For combinations of amphiboles and chrysotile (with a consideration of a correction factor between mineral classes), the potency factors correlated most highly with a fraction of fibers longer than 5&#xa0;&#x3bc;m and thinner than 0.2&#xa0;&#x3bc;m for mesothelioma, and longer than 5&#xa0;&#x3bc;m and thinner than 0.3&#xa0;&#x3bc;m for lung cancer. Because the proportion of long, thin particles in asbestiform vs. non-asbestiform dusts is higher, the cancer potencies of the former are predicted at a significantly higher level. The analysis of particle dimensionality in human lung burden demonstrates positive selection for thinner fibers (especially for amosite and crocidolite) and prevailing fraction of asbestiform habit.<br><br>CONCLUSION: Dimensions of mineral fibers can be confirmed as one of the main drivers of their carcinogenicity. The width of fibers emerges as a primary potency predictor, and fibers of all widths with lengths shorter than 5&#xa0;&#x3bc;m seem to be non-impactful for cancer risk. The mineral dust with a fibrous component is primarily carcinogenic if it contains amphibole fibers longer than 5&#xa0;&#x3bc;m and thinner than 0.25&#xa0;&#x3bc;m.},
}
@article {pmid36965797,
year = {2023},
author = {Goodman, JE and Becich, MJ and Bernstein, DM and Case, BW and Mandel, JH and Nel, AE and Nolan, R and Odo, NU and Smith, SR and Taioli, E and Gibbs, G},
title = {Non-asbestiform elongate mineral particles and mesothelioma risk: Human and experimental evidence.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {114578},
pmid = {36965797},
issn = {1096-0953},
support = {P30 CA047904/CA/NCI NIH HHS/United States ; U24 OH009077/OH/NIOSH CDC HHS/United States ; U24OH009077/ACL/ACL HHS/United States ; },
mesh = {Humans ; Epigenesis, Genetic ; *Air Pollutants, Occupational ; *Occupational Exposure ; *Lung Neoplasms/chemically induced/epidemiology ; Minerals/analysis ; *Mesothelioma/chemically induced/epidemiology ; *Asbestos/toxicity ; Tumor Microenvironment ; },
abstract = {The presentations in this session of the Monticello II conference were aimed at summarizing what is known about asbestiform and non-asbestiform elongate mineral particles (EMPs) and mesothelioma risks based on evidence from experimental and epidemiology studies. Dr. Case discussed case reports of mesothelioma over the last several decades. Dr. Taioli indicated that the epidemiology evidence concerning non-asbestiform EMPs is weak or lacking, and that progress would be limited unless mesothelioma registries are established. One exception discussed is that of taconite miners, who are exposed to grunerite. Drs. Mandel and Odo noted that studies of taconite miners in Minnesota have revealed an excess rate of mesothelioma, but the role of non-asbestiform EMPs in this excess incidence of mesothelioma is unclear. Dr. Becich discussed the National Mesothelioma Virtual Bank (NMVB), a virtual mesothelioma patient registry that includes mesothelioma patients' lifetime work histories, exposure histories, biospecimens, proteogenomic information, and imaging data that can be used in epidemiology research on mesothelioma. Dr. Bernstein indicated that there is a strong consensus that long, highly durable respirable asbestiform EMPs have the potential to cause mesothelioma, but there is continued debate concerning the biodurability required, and the dimensions (both length and diameter), the shape, and the dose associated with mesothelioma risk. Finally, Dr. Nel discussed how experimental studies of High Aspect Ratio Engineered Nanomaterials have clarified dimensional and durability features that impact disease risk, the impact of inflammation and oxidative stress on the epigenetic regulation of tumor suppressor genes, and the generation of immune suppressive effects in the mesothelioma tumor microenvironment. The session ended with a discussion of future research needs.},
}
@article {pmid36965795,
year = {2023},
author = {Chatfield, EJ},
title = {Asbestiform fibers and cleavage Fragments: Conceptual approaches for differentiation in laboratory practice and data analysis.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {114529},
doi = {10.1016/j.envres.2022.114529},
pmid = {36965795},
issn = {1096-0953},
mesh = {Animals ; *Occupational Exposure/analysis ; *Air Pollutants, Occupational/analysis ; Particle Size ; Minerals/analysis ; *Asbestos ; Asbestos, Amphibole ; Dust/analysis ; Data Analysis ; },
abstract = {The respirable fractions from 46 different crushed amphibole samples were separated by water elutriation. The dimensions of approximately 200 elongate mineral particles (EMPs) longer than 5 μm in each of these fractions were measured by transmission electron microscopy (TEM). The data were used to address three questions: 1. Can amphiboles be classified on a scale that represents the level of inhalation hazard they present? 2. Can prismatic amphibole be discriminated from amphibole asbestos on the basis of EMP size distributions and concentration measurements? 3. How do different exposure indices (Phase Contrast Microscopy Equivalent (PCME), Berman &amp; Crump protocol fibers, Chatfield extra-criteria EMPs) compare when applied to these amphibole samples? For each sample, the number of respirable EMPs longer than 5 μm per gram of respirable dust and the number of extra-criteria EMPs per gram of respirable dust were calculated. The number of respirable EMPs longer than 5 μm per gram of respirable dust and the proportion of those with dimensions associated with mesothelioma in animal studies were considered to be contributors to the inhalation hazard presented by amphibole dust. In addition to these concentration measurements, the median EMP width, median aspect ratio and the aspect ratio geometric standard deviation (GSD) were considered to be relevant parameters in discriminating prismatic amphibole from asbestiform amphibole. A plot of the aspect ratio GSD against either the concentration of respirable EMPs per gram of respirable dust, the median aspect ratio or the median width allowed discrimination. The data showed a close correspondence between exposures in terms of Chatfield extra-criteria EMPs and Berman and Crump protocol structures for all of the amphibole samples. However, although for commercial asbestos varieties exposures in terms of PCME fibers were comparable to those of the other two metrics, they greatly exceeded those for non-asbestiform amphiboles.},
}
@article {pmid36965793,
year = {2023},
author = {Cox, LA and Bogen, KT and Conolly, R and Graham, U and Moolgavkar, S and Oberdörster, G and Roggli, VL and Turci, F and Mossman, B},
title = {Mechanisms and shapes of causal exposure-response functions for asbestos in mesotheliomas and lung cancers.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {115607},
doi = {10.1016/j.envres.2023.115607},
pmid = {36965793},
issn = {1096-0953},
mesh = {Humans ; *Asbestos/toxicity ; *Mesothelioma/chemically induced/epidemiology ; *Lung Neoplasms/chemically induced/epidemiology ; Lung/pathology ; Asbestos, Amphibole/toxicity ; Inflammation/metabolism ; },
abstract = {This paper summarizes recent insights into causal biological mechanisms underlying the carcinogenicity of asbestos. It addresses their implications for the shapes of exposure-response curves and considers recent epidemiologic trends in malignant mesotheliomas (MMs) and lung fiber burden studies. Since the commercial amphiboles crocidolite and amosite pose the highest risk of MMs and contain high levels of iron, endogenous and exogenous pathways of iron injury and repair are discussed. Some practical implications of recent developments are that: (1) Asbestos-cancer exposure-response relationships should be expected to have non-zero background rates; (2) Evidence from inflammation biology and other sources suggests that there are exposure concentration thresholds below which exposures do not increase inflammasome-mediated inflammation or resulting inflammation-mediated cancer risks above background risk rates; and (3) The size of the suggested exposure concentration threshold depends on both the detailed time patterns of exposure on a time scale of hours to days and also on the composition of asbestos fibers in terms of their physiochemical properties. These conclusions are supported by complementary strands of evidence including biomathematical modeling, cell biology and biochemistry of asbestos-cell interactions in vitro and in vivo, lung fiber burden analyses and epidemiology showing trends in human exposures and MM rates.},
}
@article {pmid36965792,
year = {2023},
author = {Smith, SR},
title = {An updated review of diffuse mesothelioma of the pleura - A sentinel health event of potential elongate mineral particle pathogenicity.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {115608},
doi = {10.1016/j.envres.2023.115608},
pmid = {36965792},
issn = {1096-0953},
mesh = {Humans ; Asbestos/toxicity ; Asbestos, Amphibole/toxicity ; *Lung Neoplasms/epidemiology ; *Mesothelioma/chemically induced/epidemiology ; Minerals/adverse effects ; *Occupational Exposure/adverse effects ; Particle Size ; Particulate Matter/adverse effects ; Pleura ; Sentinel Surveillance ; Virulence ; },
abstract = {There are approximately 400 inorganic minerals in the Earth's crust, some of which can be encountered as elongate mineral particles [EMPs] with dimensional characteristics similar to the six minerals known as asbestos and other asbestiform amphiboles with established human pathogenicity. In addition, the rapidly developing field of nanotechnology is producing an ever-increasing array of high aspect ratio engineered nanomaterials [HARNs] with physical dimensions and biodurability similar to the asbestos fiber types with recognized pathogenic potential. Many of these non-asbestos/non-asbestiform EMPs and HARNs with the potential for aerosolization into the breathing zones of workers and in individuals in non-occupational environments have not yet been thoroughly studied with respect to their potential human pathogenicity, a fact which obviously poses concerns for both occupational health and public health professionals. On the basis of dose-response considerations it seems reasonable to infer that if any of these non-regulated EMPs or HARNs actually are pathogenic, then those mineral fiber exposure-induced disorders associated with the lowest cumulative exposure doses of the commercial amphibole types of asbestos, that is, diffuse mesothelioma of the pleura, and its non-malignant correlate of benign parietal pleural plaques, are those which are most likely to occur following inhalational exposures to any of the non-regulated EMPs and HARNs. Because of that observation, this paper reviews certain aspects of diffuse mesothelioma, including a summary of recent changes in the nomenclature of diffuse mesothelioma of the pleura; of both the descriptive and the analytical epidemiology of the disease; of the etiologies of mesothelioma, both "exposure" related and endogenous in nature; and of the asbestos population attributable fraction for diffuse mesotheliomas in the USA, both historically and in the future.},
}
@article {pmid36944283,
year = {2023},
author = {Belcaid, L and Bertelsen, B and Wadt, K and Tuxen, I and Spanggaard, I and Højgaard, M and Benn Sørensen, J and Ravn, J and Lassen, U and Cilius Nielsen, F and Rohrberg, K and Westmose Yde, C},
title = {New pathogenic germline variants identified in mesothelioma.},
journal = {Lung cancer (Amsterdam, Netherlands)},
volume = {179},
number = {},
pages = {107172},
doi = {10.1016/j.lungcan.2023.03.008},
pmid = {36944283},
issn = {1872-8332},
mesh = {Humans ; Genetic Predisposition to Disease ; *Lung Neoplasms/genetics ; *Mesothelioma/genetics ; *Mesothelioma, Malignant ; Germ-Line Mutation ; Germ Cells ; DNA Helicases/genetics ; },
abstract = {BACKGROUND: Mesothelioma (MM) is associated with asbestos exposure, tumor heterogeneity and aggressive clinical behavior. Identification of germline pathogenic variants (PVs) in mesothelioma is relevant for identifying potential actionable targets and genetic counseling.<br><br>METHODS: 44 patients underwent whole exome sequencing (WES) or whole genome sequencing (WGS). Germline variants were selected according to association with inherited cancer using a 168-gene in silico panel, and variants classified according to ACMG/AMP classification as pathogenic (class 5) or likely pathogenic (class 4).<br><br>RESULTS: In total, 16 patients (36%) were found to carry pathogenic or likely pathogenic variants in 13 cancer associated genes (ATM, BAP1, BRCA2, CDKN2A, FANCA, FANCC, FANCD2, FANCM, MUTYH, NBN, RAD51B, SDHA and XPC). The germline PVs occurred in DNA repair pathways, including homologous recombination repair (HRR) (75%), nucleotide excision repair (6%), cell cycle regulatory (7%), base excision repair (6%), and hypoxic pathway (6%). Five (31%) patients with a germline PV had a first or second degree relative with mesothelioma compared to none for patients without a germline PV. Previously undiagnosed BRCA2 germline PVs were identified in two patients. Potential actionable targets based on the germline PVs were found in four patients (9%).<br><br>CONCLUSION: This study revealed a high frequency of germline PVs in patients with mesothelioma. Furthermore, we identified germline PVs in two genes (NBN &amp; RAD51B) not previously associated with mesothelioma. The data support germline testing in mesothelioma and provide a rationale for additional investigation of the HRR pathway as a potential actionable target.},
}
@article {pmid36932968,
year = {2023},
author = {Taioli, E and Wolf, A and Alpert, N and Rosenthal, D and Flores, R},
title = {Malignant pleural mesothelioma characteristics and outcomes: A SEER-Medicare analysis.},
journal = {Journal of surgical oncology},
volume = {128},
number = {1},
pages = {134-141},
doi = {10.1002/jso.27243},
pmid = {36932968},
issn = {1096-9098},
mesh = {Humans ; Female ; Male ; Aged ; United States/epidemiology ; *Mesothelioma, Malignant ; Medicare ; *Mesothelioma/epidemiology/therapy ; *Pleural Neoplasms/epidemiology/therapy ; Prognosis ; *Lung Neoplasms/epidemiology/therapy ; SEER Program ; },
abstract = {BACKGROUND: Pleural mesothelioma is rare cancer linked to asbestos exposure. Previous research has indicated that female individuals have better survival than male individuals, but this has never been examined in the Surveillance, Epidemiology, and End Results (SEER)-Medicare database.<br><br>MATERIALS AND METHODS: Malignant pleural mesothelioma cases diagnosed from 1992 to 2015 were queried from the linked SEER-Medicare database. Multivariable logistic regression was used to assess the clinical and demographic factors associated with sex. A multivariable Cox proportional hazards model and propensity matching methods were used to assess sex differences in overall survival (OS) while accounting for potential confounders.<br><br>RESULTS: Among 4201 patients included in the analysis, 3340 (79.5%) were males and 861 (20.5%) females. Females were significantly older, with more epithelial histology than males were, and had significantly better OS, adjusted for confounders (adjusted hazard ratio, 0.83, 95% confidence interval: 0.76-0.90). Other variables independently associated with improved survival included younger age at diagnosis, having a spouse/domestic partner, epithelial histology, lower comorbidity score, and receipt of surgery or chemotherapy.<br><br>CONCLUSIONS: The study describes sex differences in mesothelioma occurrence, treatment, and survival and is the first to examine SEER-Medicare. It provides directions for future research into potential therapeutic targets.},
}
@article {pmid36924064,
year = {2023},
author = {Spaziani, E and Di Filippo, AR and Valle, G and Spaziani, M and Francioni, P and Caruso, G and Tamagnini, GT and Mosciatti, E and Picchio, M and De Cesare, A},
title = {A rare case of primary gastric Burkitt's lymphoma associated with malignant pleural mesothelioma.},
journal = {Annali italiani di chirurgia},
volume = {12},
number = {},
pages = {},
pmid = {36924064},
issn = {2239-253X},
mesh = {Humans ; Male ; Aged ; *Mesothelioma, Malignant/complications ; *Burkitt Lymphoma/complications/diagnosis ; *Mesothelioma/complications/diagnosis/pathology ; *Pleural Neoplasms/complications/diagnosis/pathology ; *Pleural Effusion ; *Respiratory Insufficiency/complications ; Dyspnea/complications ; },
abstract = {BACKGROUND: Primary gastric Burkitt lymphoma (PG BL) and malignant pleural mesothelioma (MPM) are rare and aggressive tumors with poor prognosis. HIV and EBV infection have a link in the aetiology of PG BL, while MPM is usually associated with asbestos exposure. Endoluminal bleeding from massive solid tumor, and dyspnea usually due to pleural effusion, are the typical clinical manifestations respectively of PG BL and MPM. In most patients just palliative treatment is indicated.<br><br>CASE REPORT: A caucasian elderly male, negative for the proven risk factors, presenting respiratory failure due to massive left pleural effusion with severe mediastinal shift. Contrast enhanced - Computed Tomography (CE-CT) showed a large mass causing circumferential thickening of the gastric fundus, infiltrating the left diaphragmatic dome and the ipsilateral crus. Macroscopically, on endoscopy the gastric fundus appeared completely occupied by an ulcerated large mass protunding in the gastric lumen. Histopathological examination from biopsy specimens taken during esophagogastroduodenoscopy and thoracoscopy allowed to make diagnosis of PG BL and MPM. The patient first underwent a placement of a chest tube drainage for the pleural effusion and then a thoracoscopic talc insufflation (TTI) in the left hemithorax. A surgical treatment of the gastric lesion was planned, due to the rapid growth and the high risk of bleeding. The patient died because of fatal cardiac arrhythmia, before undergoig abdominal surgery.<br><br>CONCLUSIONS: This report presents an unique case of PG BL associated with MPM and highlights the real challenge for the physicians to identify them in early stage, especially in patients without the proved risk factors. The onset symptoms make it a very singular case, characterized by severe dyspnea up to respiratory failure, due to massive left pleural effusion and contralateral mediastinal fluttering, without an active bleeding from the gastric mass, while CE-CT findings were instead negative for pleural thickening and positive for circumferential thickening of the gastric fundus.<br><br>KEY WORDS: Burkitt Lymphoma, Case Report, Gastric, Pleural Mesothelioma, Pleural Effusion, Respiratory Failure.},
}
@article {pmid36902544,
year = {2023},
author = {Borgeaud, M and Kim, F and Friedlaender, A and Lococo, F and Addeo, A and Minervini, F},
title = {The Evolving Role of Immune-Checkpoint Inhibitors in Malignant Pleural Mesothelioma.},
journal = {Journal of clinical medicine},
volume = {12},
number = {5},
pages = {},
pmid = {36902544},
issn = {2077-0383},
abstract = {Malignant pleural mesothelioma (MPM) is a rare cancer usually caused by asbestos exposure and associated with a very poor prognosis. After more than a decade without new therapeutic options, immune checkpoint inhibitors (ICIs) demonstrated superiority over standard chemotherapy, with improved overall survival in the first and later-line settings. However, a significant proportion of patients still do not derive benefit from ICIs, highlighting the need for new treatment strategies and predictive biomarkers of response. Combinations with chemo-immunotherapy or ICIs and anti-VEGF are currently being evaluated in clinical trials and might change the standard of care in the near future. Alternatively, some non-ICI immunotherapeutic approaches, such as mesothelin targeted CAR-T cells or denditric-cells vaccines, have shown promising results in early phases of trials and are still in development. Finally, immunotherapy with ICIs is also being evaluated in the peri-operative setting, in the minority of patients presenting with resectable disease. The goal of this review is to discuss the current role of immunotherapy in the management of malignant pleural mesothelioma, as well as promising future therapeutic directions.},
}
@article {pmid36901302,
year = {2023},
author = {Buralli, RJ and Pinheiro, RDC and Susviela, LL and Duracenko, SRC and De Capitani, EM and Savaris, A and Algranti, E},
title = {The Brazilian System for Monitoring Workers and General Population Exposed to Asbestos: Development, Challenges, and Opportunities for Workers' Health Surveillance.},
journal = {International journal of environmental research and public health},
volume = {20},
number = {5},
pages = {},
pmid = {36901302},
issn = {1660-4601},
mesh = {Humans ; *Asbestosis/epidemiology ; Brazil ; Quality of Life ; *Occupational Exposure ; Population Surveillance ; *Asbestos ; *Mesothelioma/epidemiology ; *Lung Neoplasms/epidemiology ; },
abstract = {UNLABELLED: The lack of safe levels of asbestos exposure and the long latency of asbestos-related disease (ARD) makes workers' health surveillance challenging, especially in lower-income countries. This paper aims to present the recently developed Brazilian system for monitoring workers and general population exposed to asbestos (Datamianto), and to discuss the main challenges and opportunities for workers' health surveillance.<br><br>METHODS: a descriptive study of the Datamianto development process, examining all the stages of system planning, development, improvement, validation, availability, and training of health services for its use, in addition to presenting the main challenges and opportunities for its implementation.<br><br>RESULTS: The system was developed by a group of software developers, workers' health specialists, and practitioners, and it was recently incorporated by the Ministry of Health to be used for workers' health surveillance. It can facilitate the monitoring of exposed individuals, epidemiological data analysis, promote cooperation between health services, and ensure periodical medical screening guaranteed to workers by labor legislation. Moreover, the system has a Business Intelligence (BI) platform to analyze epidemiologic data and produce near real-time reports.<br><br>CONCLUSIONS: Datamianto can support and qualify the healthcare and surveillance of asbestos-exposed workers and ARD, promoting a better quality of life for workers and improving companies' compliance with legislation. Even so, the system's significance, applicability, and longevity will depend on the efforts aimed at its implementation and improvement.},
}
@article {pmid36900330,
year = {2023},
author = {Al Khatib, MO and Pinton, G and Moro, L and Porta, C},
title = {Benefits and Challenges of Inhibiting EZH2 in Malignant Pleural Mesothelioma.},
journal = {Cancers},
volume = {15},
number = {5},
pages = {},
pmid = {36900330},
issn = {2072-6694},
abstract = {Malignant pleural mesothelioma (MPM) is an aggressive thoracic cancer that is mainly associated with prior exposure to asbestos fibers. Despite being a rare cancer, its global rate is increasing and the prognosis remains extremely poor. Over the last two decades, despite the constant research of new therapeutic options, the combination chemotherapy with cisplatin and pemetrexed has remained the only first-line therapy for MPM. The recent approval of immune checkpoint blockade (ICB)-based immunotherapy has opened new promising avenues of research. However, MPM is still a fatal cancer with no effective treatments. Enhancer of zeste homolog 2 (EZH2) is a histone methyl transferase that exerts pro-oncogenic and immunomodulatory activities in a variety of tumors. Accordingly, a growing number of studies indicate that EZH2 is also an oncogenic driver in MPM, but its effects on tumor microenvironments are still largely unexplored. This review describes the state-of-the-art of EZH2 in MPM biology and discusses its potential use both as a diagnostic and therapeutic target. We highlight current gaps of knowledge, the filling of which will likely favor the entry of EZH2 inhibitors within the treatment options for MPM patients.},
}
@article {pmid36896837,
year = {2023},
author = {Scarselli, A and Corfiati, M and Marinaccio, A},
title = {Occupational exposure register-based cohort study on mortality among asbestos-related workers in Italy after the ban.},
journal = {European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)},
volume = {32},
number = {3},
pages = {281-285},
doi = {10.1097/CEJ.0000000000000786},
pmid = {36896837},
issn = {1473-5709},
mesh = {Male ; Humans ; Cohort Studies ; *Asbestos/toxicity ; *Mesothelioma ; *Occupational Exposure/adverse effects ; Carcinogens ; Italy/epidemiology ; *Lung Neoplasms/etiology ; },
abstract = {OBJECTIVE: Asbestos is a human carcinogen and can cause some types of cancer, including mesothelioma. A relevant number of workers are still engaged in asbestos removal and disposal activities, whose actual risk of asbestos-related diseases is still scarcely recognized. The main objective of this study is to assess the cause-specific mortality among workers involved in asbestos removal and disposal after the ban in Italy.<br><br>METHODS: Data from the Information System on Occupational Exposure to carcinogens (SIREP) in the period 1996-2018 were selected. Proportionate mortality ratios (PMRs) by cause of death were calculated by linking exposure occupational information to national mortality statistics (2005-2018), assuming a Poisson distribution of the data.<br><br>RESULTS: A total of 142 deaths (all men) were identified among 13&#x2009;715 asbestos removal and disposal workers. A significant excess (P &#x2009;<&#x2009;0.05) of mesothelioma deaths was found among male workers, about five-fold the expected. A significant increase in the mortality ratio was also found for malignant melanoma of skin.<br><br>CONCLUSIONS: A risk of mesothelioma has been found among workers involved in asbestos removal and disposal. Epidemiological surveillance and promotion of prevention action plans are highly recommended for workers engaged in asbestos removal and disposal activities, to ensure compliance with regulatory requirements and reduce the still relevant risk of contracting the related tumor pathology.},
}
@article {pmid36883200,
year = {2023},
author = {Janosikova, M and Nakladalova, M and Stepanek, L},
title = {Current causes of mesothelioma: how has the asbestos ban changed the perspective?.},
journal = {Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia},
volume = {167},
number = {2},
pages = {99-108},
pmid = {36883200},
issn = {1804-7521},
mesh = {Humans ; Female ; Adolescent ; *Nanotubes, Carbon ; *Lung Neoplasms/chemically induced ; *Mesothelioma/chemically induced/complications ; *Mesothelioma, Malignant/chemically induced/complications ; *Asbestos/adverse effects ; Environmental Exposure/adverse effects ; Minerals ; *Pleural Neoplasms/chemically induced/complications ; },
abstract = {The association of mesothelioma, a lethal lung disease, with asbestos has led to an absolute ban on asbestos in at least 55 countries worldwide. The purpose of this paper is to review residual exposure to asbestos as well as other emerging causes of mesothelioma outside asbestos. The review provides detailed description of asbestos minerals, their geographical locations, mesothelioma in these areas, as well as contemporary possible sources of asbestos exposure. Second, we examine other emerging causes of mesothelioma including: ionizing radiation as the second most important risk factor after asbestos, particularly relevant to patients undergoing radiotherapy, third, carbon nanotubes which are under investigation and fourth, Simian virus 40. In the case of asbestos per se, the greatest risk is from occupational exposure during mining and subsequent processing. Of the non-occupational exposures, environmental exposure is most serious, followed by exposure from indoor asbestos minerals and secondary familial exposure. Overall, asbestos is still a major risk factor, but alternative causes should not be neglected, especially in young people, in women and those with a history of radiotherapy or living in high-risk locations.},
}
@article {pmid36876393,
year = {2023},
author = {Walther, D and Hunziker, S and Boichat Burdy, S and Ruf, F and Rossi, I and Vernez, D},
title = {[Asbestos related cancers: burden and recognition as occupational diseases].},
journal = {Revue medicale suisse},
volume = {19},
number = {816},
pages = {422-425},
doi = {10.53738/REVMED.2023.19.816.422},
pmid = {36876393},
issn = {1660-9379},
mesh = {Humans ; *Asbestos ; Health Personnel ; *Lung Neoplasms ; *Occupational Diseases ; },
abstract = {Although asbestos has been banned in Switzerland since 1989, diseases caused by asbestos are still present and increasing today. In Switzerland, per year, occupational exposure to asbestos is responsible for approximately 135 deaths from mesothelioma and 930 deaths from lung cancer, though the latter is rarely recognized as an occupational disease. Taking an occupational history is essential for all such diagnosis, especially in smokers, whose risk of lung cancer increases due to the synergistic effect of asbestos and tobacco exposure. The medical practitioner can play an important role in occupational diseases being recognized as such, which is essential for the reimbursement of medical expenses by the accident insurance companies and the allocation of indemnities and pensions for the patient or their family.},
}
@article {pmid36857650,
year = {2023},
author = {Han, J and Park, S and Yon, DK and Lee, SW and Woo, W and Dragioti, E and Koyanagi, A and Jacob, L and Kostev, K and Radua, J and Lee, S and Shin, JI and Smith, L},
title = {Global, Regional, and National Burden of Mesothelioma 1990-2019: A Systematic Analysis of the Global Burden of Disease Study 2019.},
journal = {Annals of the American Thoracic Society},
volume = {20},
number = {7},
pages = {976-983},
doi = {10.1513/AnnalsATS.202209-802OC},
pmid = {36857650},
issn = {2325-6621},
mesh = {Male ; Humans ; Female ; *Global Burden of Disease ; Quality-Adjusted Life Years ; Risk Factors ; Morbidity ; Incidence ; *Mesothelioma/epidemiology ; Global Health ; },
abstract = {Rationale: Mesothelioma has become a major health burden since World War II because of the use of asbestos. Although many countries have imposed bans on asbestos, there remain significant mortality and morbidity from mesothelioma because of its long latent period and aggressiveness. Also, the use of asbestos is increasing in low-income countries, potentiating risk of mesothelioma in the coming decades. Assessment of the global burden of mesothelioma is required to take proper measures against the disease. Objectives: To assess the burden of mesothelioma from 1990 to 2019 at the global, regional, and national levels and to investigate patterns according to sex, age, sociodemographic index, and risk factors. Methods: The numbers, rates, and age-standardized rates of incidence, death, and disability-adjusted life years (DALYs) of mesothelioma in 204 countries and territories from 1990 to 2019 were estimated using vital registration and cancer registry data. The relationship between sociodemographic index and age-standardized DALY rate was determined, and DALYs attributable to occupational exposure to asbestos were calculated. Results: In 2019, there were 34,511 (95% uncertainty interval [UI], 31,199 to 37,771) incident cases of mesothelioma globally, with an age-standardized rate of 0.43 per 100,000 persons (95% UI, 0.38 to 0.47), which decreased between 1990 and 2019 by -12.6% (95% UI, -21.8% to -2.3%). Mesothelioma was responsible for 29,251 (95% UI, 26,668 to 31,006) deaths in 2019, with an age-standardized rate of 0.36 deaths per 100,000 persons (95% UI, 0.33 to 0.39), which decreased between 1990 and 2019 by -9.6% (95% UI, -17.8% to -1.1%). The age-standardized incidence rate increased in central Europe between 1990 and 2019 by 46.1% (95% UI, 16.6% to 72.4%). The Netherlands, Australia, and the United Kingdom had the highest age-standardized incidence rates. Incidence rates were higher in men than in women ages 45-49 to 90-94 years, peaking at 85-89 years. Occupational exposure to asbestos contributed to 85.2% (95% UI, 82.1% to 88.1%) of DALYs. Conclusions: The global burden of mesothelioma is decreasing in terms of age-standardized incidence and mortality rates. Mesothelioma remains a substantial public health challenge in many parts of the world.},
}
@article {pmid36833533,
year = {2023},
author = {Lai, H and Hu, C and Qu, M and Liu, X and Xue, Y and Xu, P and Hao, D},
title = {Mesothelioma Due to Workplace Exposure: A Comprehensive Bibliometric Analysis of Current Situation and Future Trends.},
journal = {International journal of environmental research and public health},
volume = {20},
number = {4},
pages = {},
pmid = {36833533},
issn = {1660-4601},
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma ; Workplace ; *Lung Neoplasms ; Bibliometrics ; },
abstract = {Background: This article provides an overview of the current status and research progress of mesothelioma. Methods: A total of 2638 documents published from 1 January 2004 to 30 November 2022 were retrieved from the Web of Science Core Collection and analyzed via Microsoft Office Excel 2019, VOSviewer 1.6.18, and Tableau 2022.2. Results: There was an obvious increase in the number of publications regarding mesothelioma in the last 18 years, with the United States dominating the research field with 715 publications and 23,882 citations, while the University of Turin contributed the most (118). Occupational &amp; Environmental Medicine was the most popular journal (80), with Corrado Magnani being the most prolific author (52) and Michele Carbone obtaining the most citations (4472). "Oncology" and "Health Science of Environment &amp; Occupation" were the two main subjects, while the keywords "asbestos", "lung cancer", "gene expression", "apoptosis", "survival", and "cisplatin" were the most popular. Conclusions: The containment of mesothelioma calls for more participation from low- and middle-income countries, and further attention needs to be paid to clinical research.},
}
@article {pmid36831074,
year = {2023},
author = {Filetti, V and Lombardo, C and Loreto, C and Dounias, G and Bracci, M and Matera, S and Rapisarda, L and Rapisarda, V and Ledda, C and Vitale, E},
title = {Small RNA-Seq Transcriptome Profiling of Mesothelial and Mesothelioma Cell Lines Revealed microRNA Dysregulation after Exposure to Asbestos-like Fibers.},
journal = {Biomedicines},
volume = {11},
number = {2},
pages = {},
pmid = {36831074},
issn = {2227-9059},
support = {20722142130//University of Catania/ ; },
abstract = {Environmental exposure to fibers of respirable size has been identified as a risk for public health. Experimental evidence has revealed that a variety of fibers, including fluoro-edenite, can develop chronic respiratory diseases and elicit carcinogenic effects in humans. Fluoro-edenite (FE) is a silicate mineral first found in Biancavilla (Sicily, Italy) in 1997. Environmental exposure to its fibers has been correlated with a cluster of malignant pleural mesotheliomas. This neoplasm represents a public health problem due to its long latency and to its aggression not alerted by specific symptoms. Having several biomarkers providing us with data on the health state of those exposed to FE fibers or allowing an early diagnosis on malignant pleural mesothelioma, still asymptomatic patients, would be a remarkable goal. To these purposes, we reported the miRNA transcriptome in human normal mesothelial cell line (MeT-5A) and in the human malignant mesothelioma cell line (JU77) exposed and not exposed to FE fibers. The results showed a difference in the number of deregulated miRNAs between tumor and nontumor samples both exposed and not exposed to FE fibers. As a matter of fact, the effect of exposure to FE fibers is more evident in the expression of miRNA in the tumor samples than in the nontumor samples. In the present paper, several pathways involved in the pathogenesis of malignant pleural mesothelioma have been analyzed. We especially noticed the involvement of pathways that have important functions in inflammatory processes, angiogenesis, apoptosis, and necrosis. Besides this amount of data, further studies will be designed for the selection of the most significant miRNAs to test and validate their diagnostic potential, alone or in combination with other protein biomarkers, in high-risk individuals' liquid biopsy to have a noninvasive tool of diagnosis for this neoplasm.},
}
@article {pmid36825373,
year = {2023},
author = {Zona, A and Fazzo, L and Benedetti, M and Bruno, C and Vecchi, S and Pasetto, R and Minichilli, F and De Santis, M and Nannavecchia, AM and Di Fonzo, D and Contiero, P and Ricci, P and Bisceglia, L and Manno, V and Minelli, G and Santoro, M and Gorini, F and Ancona, C and Scondotto, S and Soggiu, ME and Scaini, F and Beccaloni, E and Marsili, D and Villa, MF and Maifredi, G and Magoni, M and Iavarone, I and , },
title = {[SENTIERI - Epidemiological Study of Residents in National Priority Contaminated Sites. Sixth Report].},
journal = {Epidemiologia e prevenzione},
volume = {47},
number = {1-2 Suppl 1},
pages = {1-286},
doi = {10.19191/EP23.1-2-S1.003},
pmid = {36825373},
issn = {1120-9763},
mesh = {Pregnancy ; Adolescent ; Young Adult ; Humans ; Female ; Male ; Child ; Adult ; Middle Aged ; Aged ; Infant, Newborn ; Infant ; Child, Preschool ; *Stomach Neoplasms/complications ; Cross-Sectional Studies ; Italy/epidemiology ; *Mesothelioma/etiology ; *Asbestos ; *Breast Neoplasms ; *Lymphoma, Non-Hodgkin ; *Lung Neoplasms/epidemiology ; *Urinary Bladder Neoplasms/complications ; *Liver Neoplasms ; *Colorectal Neoplasms ; },
abstract = {INTRODUCTION ADN OBJECTIVES: The Sixth Report presents the results of the "SENTIERI Project: implementation of the permanent epidemiological surveillance system of populations residing in Italian Sites of Remediation Interest", promoted and financed by the Italian Ministry of Health (Centre for Disease Control and Prevention - CCM Project 2018). The aim of this study is to update the mortality and hospitalization analyses concerning the 6,227,531 inhabitants (10.4% of the Italian population) residing in 46 contaminated sites (39 of national interest and 7 of regional interest). The sites include 316 municipalities distributed as follows: 15 in the North-East (20.3% of the investigated population); 104 in the North-West (12% of the investigated population), 32 in the Centre (12.6% of the investigated population), 165 in the South and Islands (55.5% of the investigated population). Analyses were carried out on the paediatric-adolescent (1,128,396 residents) and youth (665,284 residents) population, and a study on congenital anomalies (CA) was carried out at sites covered by congenital malformation registers. Accompanying the epidemiological assessments, site-specific socioeconomic conditions were examined and an overall estimate of excess risk for populations residing at contaminated sites was drawn up. By means of a systematic review of the scientific literature, the epidemiological evidence on causal links between sources of environmental exposure and health effects was updated to identify pathologies of a priori interest.<br><br>METHODOLOGY: In the 46 sites included in the SENTIERI Project, mortality (time window: 2013-2017) and hospital admissions (time window: 2014-2018) of the general population of all ages, divided by gender, and of the paediatric-adolescent (0-1 year, 0-14 years, 0-19 years), youth (20-29 years), and overall (0-29 years) age groups, divided by gender, were analysed. In 21 sites, CA diagnosed within the first year of life were studied. Standardised mortality ratios (SMR) and hospitalization ratios (SHR) were calculated with reference to the rates in the regions to which the sites belong. The reference population was calculated net of residents in the sites. CA were studied by calculating the prevalence per 10,000 births and the ratio, multiplied by 100, between the cases observed at the site and those expected on the basis of the prevalences observed in the reference area (region or sub-regional area of belonging, according to the geographical coverage of the registry). The socioeconomic condition studied in the 46 sites is based on the convergence of three deprivation indicators with respect to the reference region: deprivation index at municipal level, deprivation index at census section level, premature mortality indicator (age range 30-69 years) for chronic non-communicable diseases. For the estimation of excess risk for the entire study population, meta-analysis of the mortality and hospitalization risk estimates for each site was carried out and the number of excess deaths estimated for the sites as a whole. The epidemiological evidence was updated through a systematic literature review (January 2009-May 2020), following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The search was carried out on the search engines MEDLINE, EMBASE and Web of Science; the quality of the studies included in the review was assessed using the AMSTAR 2 checklist for systematic reviews and the NewCastle-Ottawa Scale for observational studies in the case of cohort and case-control studies and a modified version thereof for ecological and cross-sectional studies. The update was based on the selection of 14 systematic reviews, 15 primary studies, 6 monographs/reports from international scientific organisations on health effects due to the presence of environmental exposure sources.<br><br>RESULTS: Mortality. The a priori causes of interest that occur most frequently in excess are, in descending order: malignant lung cancer, malignant mesothelioma of the pleura, malignant bladder cancer, respiratory diseases, non-Hodgkin lymphomas, malignant liver cancer, all malignant tumours, malignant colorectal cancer, malignant stomach cancer, total mesotheliomas, malignant breast cancer, and asbestosis. Hospitalization. The a priori causes of interest that occur most frequently in excess are represented in descending order by: respiratory diseases, malignant lung cancer, malignant tumours of the pleura, malignant bladder cancer, malignant breast cancer, malignant liver cancer, asthma, malignant colorectal cancer, all malignant tumours, malignant stomach cancer, non-Hodgkin's lymphomas, acute respiratory diseases, leukaemias. The differences observed between mortality and hospitalization can be attributed to the intrinsic characteristics of the diseases (higher or lower lethality, gender differences in incidence), lifestyles, and occupational phenomena. Age classes. Excesses of general mortality were observed in the first year of life at the Manfredonia, Basso Bacino Fiume Chienti, Litorale Domizio Flegreo and Agro Aversano sites; in the 0-1 year and 0-19 year age groups at Casale Monferrato; in the paediatric age group at Serravalle Scrivia and at the Trento Nord site; in the 0-19 year age group at Sassuolo Scandiano; in the young age group (0-29 years) at the two municipalities of Cerchiara and Cassano (Crotone-Cassano-Cerchiara site). With regard to hospitalization due to natural causes, risk excesses in both genders are found in the first year of life in 35% of the sites (Porto Torres industrial areas, Bari-Fibronit, Basso bacino fiume Chienti, Bolzano, Crotone-Cassano-Cerchiara, Cerro al Lambro, Bologna ETR large repair workshop, Gela, Manfredonia, Massa Carrara, Pioltello Rodano, Pitelli, Priolo, Sesto San Giovanni, Trento Nord, and Trieste). These same sites, with the addition of Casale Monferrato, Cengio e Saliceto, Serravalle Scrivia, and Sulcis-Iglesiente-Guspinese (total: 43% of sites), show excesses for all natural causes, in both genders, even in the paediatric-adolescent age group (0-19 years). Among young adults (20-29 years), the analyses show excesses of hospitalization for all natural causes in both genders in the Bolzano, Crotone-Cassano-Cerchiara, Gela, Manfredonia, Pitelli, Priolo, and Sulcis-Iglesiente-Guspinese sites. Among young women only, excesses for all natural causes are also found in Brescia Caffaro, Brindisi, Broni, Casale Monferrato, Crotone-Cassano-Cerchiara, Falconara Marittima, Fidenza, and Massa Carrara. Congenital anomalies. In the 21 sites investigated for CA, 10,126 cases of CA, validated by participating registers, were analysed out of 304,620 resident births. Genital CA is the subgroup for which the greatest number of excesses was observed (in 6 out of 21 sites). The available evidence does not allow a causal link to be established between the excesses observed for specific subgroups of ACs and exposure to industrial sources, but the results suggest further action. The interpretation of the results appears, in fact, particularly complex as the scientific literature on the association between exposure to industrial sources and AC is very limited. Socioeconomic status. The sites in which the indicators converge to show the presence of fragility are: Litorale Vesuviano area, Val Basento industrial areas, Basso Bacino fiume Chienti, Biancavilla, Crotone-Cassano-Cerchiara, Litorale Domizio Flegreo and Agro Aversano, Livorno, Massa Carrara, Trieste. Global impact. Over the period 2013-2017, an estimated 8,342 excess deaths (CI90% 1,875-14,809) or approximately 1,668 excess cases/year, 4,353 excess deaths among males (CI90% 334-8,372) and 3,989 among females (CI90% -1,122;9,101). The pooled excess risk of general mortality is 2% in both genders (pooled SMR 1.02; CI90% 1.00-1.04). The proportion of excess deaths to total observed deaths is almost constant over time, rising from 2.5% in 1995-2002 to 2.6% in 2013-2017. The number of deaths in absolute value is also very similar between the periods analysed. Deaths from all malignant tumours contribute the most by accounting for 56% of the observed excesses, the excess risk of mortality from malignant tumours across all sites, compared to the reference populations, is 4% in the male population (pooled SMR 1.04; CI90% 1.01-1.06) and 3% among the female population (pooled SMR 1.03; CI90% 1.01-1.05). Hospitalization (2014-2018) in the 46 sites as a whole was in excess of 3% for all causes, in both genders, for all major disease groups (males: SHR pooled 1.03; CI90% 1.01-1.04 - females: SHR pooled 1.03; CI90% 1.01-1.05). The results for the pooled estimates at the 46 sites on the general population, both with regard to mortality and hospitalization, are consistent in indicating excess risk in both genders for all the diseases considered and, in particular, for all malignancies. A total of 1,409 paediatric-adolescent deaths and 999 young adult deaths were observed, and the pooled analysis of mortality across the 46 sites showed no critical issues, with pooled estimates for all causes, perinatal morbid conditions and all malignancies falling short of expectations. The analysis of hospitalizations, on the other hand, showed an excess risk of 8% (males: SHR pooled 1.08; CI90% 1.03-1.13 - females: SHR pooled 1.08; CI90% 1.03-1.14) for all causes in the first year of life, and in paediatric-adolescent and juvenile age of 3-4% among males (age 0-19 years: SHR pooled 1.04; CI90% 1.02-1.06 - age 20-29 years: SHR pooled 1.03; CI90% 1.00-1.05) and 5% among females (in both age groups; SHR pooled 1.05; CI90% 1.02-1.08). The pooled analysis of mortality for the a priori identified diseases reported excesses for specific diseases in the group of sites with sources of exposure associated with them. Mortality from total mesotheliomas is three times higher at sites with asbestos present (males: pooled SMR 3.02; CI90% 2.18-3.87 - females: pooled SMR 3.61; CI90% 2.33-4.88) and that from pleural mesotheliomas more than two times higher at the group of sites with asbestos and port areas (males: pooled SMR 2.47; CI90% 1.94-3.00 - females: pooled SMR 2.43; CI90% 1.67-3.19). Lung cancer was in excess by 6% among males (pooled SMR 1.06; CI90% 1.03-1.10) and 7% among females (pooled SMR 1.07; CI90% 1.00-1.13). In addition, there are excess mortalities for colorectal cancer at sites with chemical plants, by 4 % among males (SMR pooled 1.04; CI90% 1.01-1.08) and 3 % among females (SMR pooled 1.03; CI90% 1.00-1.07) and for bladder cancer among the male population of sites with landfills (+6 %: SMR pooled 1.06; CI90% 1.02-1.11). Among the diseases of a priori interest, stomach and soft tissue cancers are at fault as a cause of death among all the sites considered.<br><br>LITERATURE REVIEW: The update of the epidemiological evidence underlying the Sixth SENTIERI Report has highlighted in the general population a possible association, previously undiscovered, between certain diseases and residence near petrochemical and steel plants, landfills, coal mines and asbestos sources.<br><br>CONCLUSIONS AND PERSPECTIVES: Despite the fact that this is an ecological study, and the excesses of pathologies with multifactorial aetiology can never be mechanically attributed solely to the environmental pressure factors that exist or existed in the areas studied, the ability to identify the excesses found in the contaminated sites investigated by the SENTIERI Project confirms the validity of this method of assessing the site-specific health profile, based on the use of epidemiological evidence to identify pathologies of interest a priori. In interpreting the data and lending robustness to what has been observed, comparison with the results obtained in previous Reports is essential. The global estimates give an overall picture that shows excess mortality and hospitalization in these populations compared to the rest of the population, and show how, for specific pathologies, comparable effects are produced at sites with similar contamination characteristics. The themes developed in the in-depth chapters broaden the vision and understanding of the complex interactions between environment and health, describe the possibilities offered by new ways of communicating the results, and confirm the modernity of a Project that began way back in 2006, and that could be grafted onto the objectives of the National Recovery and Resilience Plan within the framework of the Operational Programme Health, Environment, Biodiversity and Climate.},
}
@article {pmid36819965,
year = {2023},
author = {Gariazzo, C and Gasparrini, A and Marinaccio, A},
title = {Asbestos Consumption and Malignant Mesothelioma Mortality Trends in the Major User Countries.},
journal = {Annals of global health},
volume = {89},
number = {1},
pages = {11},
pmid = {36819965},
issn = {2214-9996},
mesh = {Male ; Humans ; *Mesothelioma, Malignant ; *Asbestos ; *Mesothelioma/epidemiology ; World Health Organization ; Linear Models ; *Lung Neoplasms ; *Pleural Neoplasms ; *Occupational Exposure ; },
abstract = {BACKGROUND: The causal association between mesothelioma and asbestos exposure is conclusive, and many studies have proved that the trend in asbestos use is a strong predictor of the pattern in mesothelioma cases with an adequate latency time (generally around 30-40 years or more). Recently, a novel approach for predicting malignant pleural mesothelioma, based on asbestos consumption trend and using distributed non-linear models, has been applied.<br><br>OBJECTIVES: The purpose of this study is to analyse trends in asbestos consumption and malignant mesothelioma mortality in the major asbestos-user countries. Furthermore, we applied distributed non-linear models to estimate and compare epidemiological relationships between asbestos consumption and mesothelioma mortality across these countries.<br><br>METHODS: The study involves major asbestos-user countries in which historical asbestos consumption and mesothelioma mortality data are available. Data on asbestos consumption were derived from worldwide asbestos supply and mesothelioma mortality data from World Health Organization (WHO) mortality archives. A quasi-Poisson generalized linear model was used to model past asbestos exposure and male mesothelioma mortality rates in each country. Exposure-response associations have been modelled using distributed lag non-linear models.<br><br>FINDINGS AND CONCLUSIONS: According to the criteria defined above, we selected 18 countries with raw asbestos cumulative consumptions higher than two million tons in the period 1933-2012. Overall, a clear linear relationship can be observed between total consumption and total deaths for mesothelioma. Country-specific exposure, lag and age-response relationships were identified and common functions extracted by a meta-analysis procedure. Non-linear models appear suitable and flexible tools for investigating the association between mesothelioma mortality and asbestos consumption. There is a need to improve the global epidemiological surveillance of asbestos-related diseases, particularly mesothelioma mortality, and the absence of reliable data for some major asbestos-user countries is a real concern. A reliable assessment of mesothelioma mortality is a fundamental step towards increasing the awareness of related risks and the need of an international ban on asbestos.},
}
@article {pmid36808895,
year = {2023},
author = {Sejben, A and Pancsa, T and Tiszlavicz, L and Furák, J and Paróczai, D and Zombori, T},
title = {Highlighting the immunohistochemical differences of malignant mesothelioma subtypes via case presentations.},
journal = {Thoracic cancer},
volume = {14},
number = {10},
pages = {857-863},
pmid = {36808895},
issn = {1759-7714},
mesh = {Humans ; *Mesothelioma, Malignant/diagnosis ; *Mesothelioma/pathology ; Mesothelin ; Calbindin 2 ; Biomarkers, Tumor/metabolism ; Immunohistochemistry ; Diagnosis, Differential ; *Lung Neoplasms/pathology ; },
abstract = {Malignant mesothelioma (MM) is a rare tumor of mesothelial cells, with an increasing incidence both in developed and developing countries. MM has three major histological subtypes, in order of frequency, according to the World Health Organization (WHO) Classification of 2021: epithelioid, biphasic, and sarcomatoid MM. Distinction may be a challenging task for the pathologist, due to the unspecific morphology. Here, we present two cases of diffuse MM subtypes to emphasize the immunohistochemical (IHC) differences, and to facilitate diagnostic difficulties. In our first case of epithelioid mesothelioma, the neoplastic cells showed cytokeratin 5/6 (CK5/6), calretinin, and Wilms-tumor-1 (WT1) expression, while remaining negative with thyroid transcription factor-1 (TTF-1). BRCA1 associated protein-1 (BAP1) negativity was seen in the neoplastic cells' nucleus, reflecting loss of the tumor suppressor gene. In the second case of biphasic mesothelioma, expression of epithelial membrane antigen (EMA), CKAE1/AE3, and mesothelin was observed, while WT1, BerEP4, CD141, TTF1, p63, CD31, calretinin, and BAP1 expressions were not detected. Due to the absence of specific histological features, the differentiation between MM subtypes could be a challenging task. In routine diagnostic work, IHC may be the proper method in distinction. According to our results and literature data, CK5/6, mesothelin, calretinin, and Ki-67 should be applied in subclassification.},
}
@article {pmid36800547,
year = {2023},
author = {Hocking, AJ and Thomas, EM and Prabhakaran, S and Jolley, A and Woods, SL and Soeberg, MJ and Klebe, S},
title = {Molecular Characterization of Testicular Mesothelioma and the Role of Asbestos as a Causative Factor.},
journal = {Archives of pathology &amp; laboratory medicine},
volume = {147},
number = {12},
pages = {1446-1450},
doi = {10.5858/arpa.2022-0283-OA},
pmid = {36800547},
issn = {1543-2165},
mesh = {Male ; Humans ; *Mesothelioma, Malignant ; *Asbestos/adverse effects ; *Mesothelioma/genetics ; *Testicular Neoplasms/genetics/pathology ; },
abstract = {CONTEXT.&#x2014;: Mesothelioma of the tunica vaginalis testis (TVT) is an extremely rare form of mesothelioma.<br><br>OBJECTIVE.&#x2014;: To compare the clinical and molecular characteristics of mesothelioma of the TVT with those of mesothelioma at other more common sites, including the relationship with exposure to asbestos.<br><br>DESIGN.&#x2014;: We present clinical and pathological data for 9 cases of primary TVT mesothelioma. We performed whole-genome sequencing on 3 cases for the first time.<br><br>RESULTS.&#x2014;: The majority (7 of 9 cases) of TVT mesotheliomas were epithelioid, with the remaining 2 cases showing biphasic morphology. Morphology and immunohistochemical profiles were indistinguishable from mesothelioma elsewhere. Asbestos exposure was documented for 7 of the 9 cases, with no information for 2 cases. The 3 TVT mesothelioma cases that underwent whole-genome sequencing displayed a mutational profile similar to that of mesothelioma at other sites, including NF2 and TP53 mutations.<br><br>CONCLUSIONS.&#x2014;: The clinical and molecular profile of TVT mesothelioma is similar to that of mesothelioma elsewhere.},
}
@article {pmid36785667,
year = {2023},
author = {Kapila, D and Panwar, S and Raja, MKMM and Mondal, T and Rafi, SM and Singh, SP and Kumar, B},
title = {Applications of Neural Network-Based Plan-Cancer Method for Primary Diagnosis of Mesothelioma Cancer.},
journal = {BioMed research international},
volume = {2023},
number = {},
pages = {3164166},
pmid = {36785667},
issn = {2314-6141},
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/diagnosis/pathology ; Artificial Intelligence ; *Asbestos/toxicity ; Neural Networks, Computer ; },
abstract = {"Malignant mesothelioma (MM)" is an uncommon although fatal form of cancer. The proper MM diagnosis is crucial for efficient therapy and has significant medicolegal implications. Asbestos is a carcinogenic material that poses a health risk to humans. One of the most severe types of cancer induced by asbestos is "malignant mesothelioma." Prolonged shortness of breath and continuous pain are the most typical symptoms of the condition. The importance of early treatment and diagnosis cannot be overstated. The combination "epithelial/mesenchymal appearance of MM," however, makes a definite diagnosis difficult. This study is aimed at developing a deep learning system for medical diagnosis MM automatically. Otherwise, the sickness might cause patients to succumb to death in a short amount of time. Various forms of artificial intelligence algorithms for successful "Malignant Mesothelioma illness" identification are explored in this research. In relation to the concept of traditional machine learning, the techniques support "Vector Machine, Neural Network, and Decision Tree" are chosen. SPSS has been used to analyze the result regarding the applications of Neural Network helps to diagnose MM.},
}
@article {pmid36781903,
year = {2023},
author = {Vasuri, F and Deserti, M and Corradini, AG and Tavolari, S and Relli, V and Palloni, A and Frega, G and Curti, S and Mattioli, S and Cescon, M and D'Errico, A and Brandi, G},
title = {Asbestos exposure as an additional risk factor for small duct intrahepatic cholangiocarcinoma: a pilot study.},
journal = {Scientific reports},
volume = {13},
number = {1},
pages = {2580},
pmid = {36781903},
issn = {2045-2322},
mesh = {Humans ; Pilot Projects ; *Asbestos/toxicity ; *Cholangiocarcinoma/etiology/chemically induced ; Risk Factors ; Bile Ducts, Intrahepatic/pathology ; *Bile Duct Neoplasms/etiology/chemically induced ; },
abstract = {Intrahepatic cholangiocarcinoma (iCCA) is a rare malignancy, recently classified in small duct and large duct morphological subtypes. Growing evidence suggests asbestos as a putative risk factor for iCCA, albeit no correlation between asbestos and iCCA morphology has been investigated so far. The aim of the present study was to assess the relationship between asbestos exposure and iCCA morphological subtype. Forty patients with surgically removed iCCA were prospectively enrolled: asbestos exposure was assessed according to the Italian National Mesothelioma Register questionnaire. From the surgical iCCA specimens the main histopathological variables were collected, including the small duct (sd-iCCA, 32 patients) and large duct subtypes (ld-iCCA, 8 patients). Five sd-iCCA cases had a definite/probable occupational exposure to asbestos, while no cases of ld-iCCA were classified as being occupationally exposed (definite/probable). Other kind of asbestos exposure (i.e. possible occupational, familial, environmental) were recorded in 16 sd-iCCA and 3 ld-iCCA. Cases with unlikely exposure to asbestos were 11 sd-iCCA (35.5%) and 5 ld-iCCA (62.5%). In conclusion, these findings seem to indicate that sd-iCCA might be more frequently associated to asbestos exposure rather than ld-iCCA, suggesting that asbestos fibres might represent a parenchymal, rather than a ductal risk factor for iCCA. This pilot study must be confirmed by further case-control studies or large independent cohorts.},
}
@article {pmid36781827,
year = {2023},
author = {Iwadare, T and Kimura, T and Nagata, Y and Suzuki, H and Kunimoto, H and Kitabatake, H and Seki, A and Ochi, Y and Hara, E and Umemura, T},
title = {A case of malignant peritoneal mesothelioma with a Fitz-Hugh-Curtis syndrome-like imaging finding.},
journal = {Clinical journal of gastroenterology},
volume = {16},
number = {3},
pages = {372-376},
pmid = {36781827},
issn = {1865-7265},
mesh = {Male ; Female ; Humans ; Middle Aged ; *Pelvic Inflammatory Disease/diagnosis ; *Hepatitis/diagnosis ; *Peritonitis/diagnosis ; *Peritoneal Neoplasms/diagnostic imaging/drug therapy ; *Mesothelioma, Malignant ; *Mesothelioma/diagnosis/diagnostic imaging ; },
abstract = {Malignant peritoneal mesothelioma (MPeM) is a rare disease with a poor prognosis that develops in the mesothelial cells of the peritoneum. We encountered a 48-year-old man with no prior asbestos exposure who visited our hospital with abdominal pain. Laboratory findings showed elevated C-reactive protein of 15.5 mg/dL. Contrast-enhanced computed tomography (CT) detected a Fitz-Hugh-Curtis syndrome-like contrast effect on the liver surface and thickening of the peritoneum. Blood culture, Mycobacterium tuberculosis-specific IFN-γ release assay, Chlamydia trachomatis and Neisseria gonorrhoeae DNA testing, and antinuclear antibody were all negative. CA125 was high at 124.8 U/mL. The laparoscopy for diagnostic purposes revealed adhesions between the liver surface and peritoneum in addition to numerous small and large white nodules on the peritoneum. Biopsy of the nodules confirmed the diagnosis of epithelial-type MPeM. Treatment was initiated with combined cisplatin and pemetrexed, and CT 6 months later showed a reduced contrast effect on the liver surface and improved peritoneal thickening. A Fitz-Hugh-Curtis syndrome-like contrast effect on the liver surface on contrast-enhanced CT may help identify MPeM.},
}
@article {pmid36775192,
year = {2023},
author = {Huang, J and Chan, SC and Pang, WS and Chow, SH and Lok, V and Zhang, L and Lin, X and Lucero-Prisno, DE and Xu, W and Zheng, ZJ and Elcarte, E and Withers, M and Wong, MCS and , },
title = {Global Incidence, Risk Factors, and Temporal Trends of Mesothelioma: A Population-Based Study.},
journal = {Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
volume = {18},
number = {6},
pages = {792-802},
doi = {10.1016/j.jtho.2023.01.095},
pmid = {36775192},
issn = {1556-1380},
mesh = {Female ; Humans ; Male ; Incidence ; *Lung Neoplasms/complications ; *Mesothelioma/epidemiology/etiology ; *Mesothelioma, Malignant ; *Asbestos/adverse effects ; Risk Factors ; },
abstract = {INTRODUCTION: Mesothelioma is an uncommon type of cancer which has received little attention. This study aims to evaluate the global disease burden; trends of mesothelioma by age, sex, and geographic locations; and its risk factors on the population level.<br><br>METHODS: The Global Cancer Observatory, Cancer Incidence in Five Continents Plus, and Global Burden of Disease were accessed for mesothelioma incidence and its risk factors worldwide. The associations between mesothelioma incidence and asbestos were evaluated for each country by multivariable linear regression analysis by sex and age. Average annual percentage change (AAPC) was calculated using Joinpoint regression to evaluate the epidemiologic trends of mesothelioma.<br><br>RESULTS: The age-standardized rate of mesothelioma was 0.30 per 100,000 persons with Northern Europe reporting the highest incidence rates. The incidence rate of the male population was much higher than that of the females. Countries with higher human development index (&#x3b2;&#xa0;= 0.119, confidence interval [CI]: 0.073-0.166, p < 0.001), gross domestic product per capita (&#x3b2;&#xa0;= 0.133, CI: 0.106-0.161, p < 0.001), and asbestos exposure (&#x3b2;&#xa0;= 0.087, CI: 0.073-0.102, p < 0.001) had higher mesothelioma. The overall trend of mesothelioma incidence was decreasing, although an increase was observed in Bulgaria (AAPC: 5.56, 95% CI: 2.94-8.24, p&#xa0;= 0.001) and Korea (AAPC: 3.24, 95% CI: 0.08-6.49, p&#xa0;= 0.045).<br><br>CONCLUSIONS: There was a substantial declining incidence trend of mesothelioma in the past decade possibly related to the restriction of the use of asbestos in some countries. Meanwhile, the increasing trend in mesothelioma incidence observed in females might be indicative of an increase in environmental exposure to mineral fibers.},
}
@article {pmid36765599,
year = {2023},
author = {Palstrøm, NB and Overgaard, M and Licht, P and Beck, HC},
title = {Identification of Highly Sensitive Pleural Effusion Protein Biomarkers for Malignant Pleural Mesothelioma by Affinity-Based Quantitative Proteomics.},
journal = {Cancers},
volume = {15},
number = {3},
pages = {},
pmid = {36765599},
issn = {2072-6694},
support = {NA//Odense University Hospital/ ; },
abstract = {Malignant pleural mesothelioma (MPM) is an asbestos-associated, highly aggressive cancer characterized by late-stage diagnosis and poor prognosis. Gold standards for diagnosis are pleural biopsy and cytology of pleural effusion (PE), both of which are limited by low sensitivity and markedly inter-observer variations. Therefore, the assessment of PE biomarkers is considered a viable and objective diagnostic tool for MPM diagnosis. We applied a novel affinity-enrichment mass spectrometry-based proteomics method for explorative analysis of pleural effusions from a prospective cohort of 84 patients referred for thoracoscopy due to clinical suspicion of MPM. Protein biomarkers with a high capability to discriminate MPM from non-MPM patients were identified, and a Random Forest algorithm was applied for building classification models. Immunohistology of pleural biopsies confirmed MPM in 40 patients and ruled out MPM in 44 patients. Proteomic analysis of pleural effusions identified panels of proteins with excellent diagnostic properties (90-100% sensitivities, 89-98% specificities, and AUC 0.97-0.99) depending on the specific protein combination. Diagnostic proteins associated with cancer growth included galactin-3 binding protein, testican-2, haptoglobin, Beta ig-h3, and protein AMBP. Moreover, we also confirmed previously reported diagnostic accuracies of the MPM markers fibulin-3 and mesothelin measured by two complementary mass spectrometry-based methods. In conclusion, a novel affinity-enrichment mass spectrometry-based proteomics identified panels of proteins in pleural effusion with extraordinary diagnostic accuracies, which are described here for the first time as biomarkers for MPM.},
}
@article {pmid36765038,
year = {2023},
author = {Yang, H and Gao, Y and Xu, D and Xu, K and Liang, SQ and Yang, Z and Scherz, A and Hall, SRR and Forster, S and Berezowska, S and Yao, F and Ochsenbein, AF and Marti, TM and Kocher, GJ and Schmid, RA and Dorn, P and Peng, RW},
title = {MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma.},
journal = {Cell death discovery},
volume = {9},
number = {1},
pages = {55},
pmid = {36765038},
issn = {2058-7716},
support = {KFS-4851-08-2019//Krebsliga Schweiz (Ligue Suisse Contre le Cancer)/ ; 310030_192648//Schweizerischer Nationalfonds zur F&#xf6;rderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)/ ; },
abstract = {Malignant pleural mesothelioma (MPM) is a lethal malignancy etiologically caused by asbestos exposure, for which there are few effective treatment options. Although asbestos carcinogenesis is associated with reactive oxygen species (ROS), the bona fide oncogenic signaling pathways that regulate ROS homeostasis and bypass ROS-evoked apoptosis in MPM are poorly understood. In this study, we demonstrate that the mitogen-activated protein kinase (MAPK) pathway RAS-RAF-MEK-ERK is hyperactive and a molecular driver of MPM, independent of histological subtypes and genetic heterogeneity. Suppression of MAPK signaling by clinically approved MEK inhibitors (MEKi) elicits PARP1 to protect MPM cells from the cytotoxic effects of MAPK pathway blockage. Mechanistically, MEKi induces impairment of homologous recombination (HR) repair proficiency and mitochondrial metabolic activity, which is counterbalanced by pleiotropic PARP1. Consequently, the combination of MEK with PARP inhibitors enhances apoptotic cell death in vitro and in vivo that occurs through coordinated upregulation of cytotoxic ROS in MPM cells, suggesting a mechanism-based, readily translatable strategy to treat this daunting disease. Collectively, our studies uncover a previously unrecognized scenario that hyperactivation of the MAPK pathway is an essential feature of MPM and provide unprecedented evidence that MAPK signaling cooperates with PARP1 to homeostatically maintain ROS levels and escape ROS-mediated apoptosis.},
}
@article {pmid36757881,
year = {2023},
author = {Bonde, A and Singh, R and Prasad, SR and Kamireddy, D and Aggarwal, A and Ramani, N and Saboo, S and Shanbhogue, K and Dasyam, AK and Katabathina, VS},
title = {Mesotheliomas and Benign Mesothelial Tumors: Update on Pathologic and Imaging Findings.},
journal = {Radiographics : a review publication of the Radiological Society of North America, Inc},
volume = {43},
number = {3},
pages = {e220128},
doi = {10.1148/rg.220128},
pmid = {36757881},
issn = {1527-1323},
mesh = {Humans ; *Adenomatoid Tumor ; Positron Emission Tomography Computed Tomography ; *Mesothelioma/diagnostic imaging/therapy ; *Mesothelioma, Malignant ; *Pleural Neoplasms/pathology ; *Neoplasms, Mesothelial ; Biomarkers, Tumor ; },
abstract = {A diverse spectrum of benign entities and malignant neoplasms originate from the monotonous mesothelium that lines the serosal membranes of the pleural, pericardial, and peritoneal cavities. The mesothelium of myriad sites shows a common origin from the lateral plate mesoderm; primary mesothelial tumors thus demonstrate similar pathogenesis, imaging findings, and treatment options. Significant changes have been made in the 2021 World Health Organization (WHO) classification schemata of the pleural and pericardial tumors on the basis of recent advances in pathology and genetics. While malignant mesotheliomas are biologically aggressive malignancies that occur primarily in patients exposed to asbestos with attendant poor survival rates, well-differentiated papillary mesothelial tumors and adenomatoid tumors charter a benign clinical course with an excellent prognosis. Mesothelioma in situ is a newly characterized entity represented by recurrent unexplained pleural effusions without any identifiable mass at imaging or thoracoscopy. Immunohistochemical markers based on BAP1, MTAP, CDKN2A, and TRAF7 gene mutations help differentiate diffuse mesotheliomas from benign mesothelial proliferations and localized mesotheliomas. Cross-sectional imaging modalities, including US, CT, MRI, and fluorine 18-fluorodeoxyglucose (FDG) PET/CT, permit diagnosis and play a major role in staging and assessing surgical resectability. Imaging studies are invaluable in providing noninvasive and quantitative assessment of tumor response in patients with unresectable disease. Owing to significant overlap in patient characteristics and pathomorphology, accurate diagnosis based on advanced histopathology techniques and genetic abnormalities is imperative for optimal management and prognostication. While patients with nonepithelioid pleural mesotheliomas benefit from immunotherapy, novel targeted therapies for CDKN2A-, NF2-, and BAP1-altered mesotheliomas are under consideration. [©] RSNA, 2023 Quiz questions for this article are available through the Online Learning Center.},
}
@article {pmid36754595,
year = {2023},
author = {Walker-Bone, K and Benke, G and MacFarlane, E and Klebe, S and Takahashi, K and Brims, F and Sim, MR and Driscoll, TR},
title = {Incidence and mortality from malignant mesothelioma 1982-2020 and relationship with asbestos exposure: the Australian Mesothelioma Registry.},
journal = {Occupational and environmental medicine},
volume = {80},
number = {4},
pages = {186-191},
doi = {10.1136/oemed-2022-108669},
pmid = {36754595},
issn = {1470-7926},
mesh = {Male ; Humans ; Female ; Aged, 80 and over ; *Mesothelioma, Malignant/chemically induced/complications ; Incidence ; Australia/epidemiology ; *Mesothelioma/etiology ; *Asbestos/adverse effects ; *Occupational Exposure/adverse effects ; Registries ; },
abstract = {OBJECTIVES: Malignant mesothelioma is an uncommon cancer associated with asbestos exposure, predominantly occupational. Asbestos has been banned in Australia since 2003 but mesothelioma has a long latency and incident cases continue to present. The Australian Mesothelioma Registry was incepted to collect systematic data about incidence and mortality alongside asbestos exposure.<br><br>METHODS: Benefiting from the Australian national system of cancer notification, all incident cases of mesothelioma in all states and territories are fast-tracked and notified regularly. Notified patients are contacted asking for consent to collect exposure information, initially by postal questionnaire and subsequently by telephone interview. Age-standardised annual incidence rates and mortality rates were calculated. Asbestos exposure was categorised as occupational, non-occupational, neither or, both; and as low, or high, probability of exposure.<br><br>RESULTS: Mesothelioma incidence appears to have peaked. The age-standardised incidence rates have declined steadily since the early 2000s (peaking in males at 5.9/100 000 and in all-persons at 3.2/100 000), driven by rates in males, who comprise the majority of diagnosed cases. Rates in women have remained fairly stable since that time. Age-standardised mortality rates have followed similar trends. Mesothelioma remains the most common in those aged over 80 years. Nearly all (94%) cases were linked with asbestos exposure (78% occupational in men; 6.8% in women).<br><br>CONCLUSIONS: With effective control of occupational asbestos use, the decline in age-standardised incidence and death rates has occurred. Incidence rates among women, in whom occupational asbestos exposure is rarely detectable, remain unchanged, pointing to the role of household and /or environmental asbestos exposure.},
}
@article {pmid36740402,
year = {2023},
author = {Cunningham, R and Jia, S and Purohit, K and Salem, O and Hui, NS and Lin, Y and Carragher, NO and Hansen, CG},
title = {YAP/TAZ activation predicts clinical outcomes in mesothelioma and is conserved in in vitro model of driver mutations.},
journal = {Clinical and translational medicine},
volume = {13},
number = {2},
pages = {e1190},
pmid = {36740402},
issn = {2001-1326},
support = {19-0238/AICR_/Worldwide Cancer Research/United Kingdom ; 204804/Z/16/Z/WT_/Wellcome Trust/United Kingdom ; /WT_/Wellcome Trust/United Kingdom ; },
mesh = {Humans ; Hippo Signaling Pathway ; *Mesothelioma/genetics/metabolism/pathology ; Mutation/genetics ; Protein Serine-Threonine Kinases/metabolism ; *Transcription Factors/genetics/metabolism ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; YAP-Signaling Proteins ; },
abstract = {The Hippo signalling pathway is dysregulated across a wide range of cancer types and, although driver mutations that directly affect the core Hippo components are rare, a handful is found within pleural mesothelioma (PM). PM is a deadly disease of the lining of the lung caused by asbestos exposure. By pooling the largest-scale clinical datasets publicly available, we here interrogate associations between the most prevalent driver mutations within PM and Hippo pathway disruption in patients, while assessing correlations with a variety of clinical markers. This analysis reveals a consistent worse outcome in patients exhibiting transcriptional markers of YAP/TAZ activation, pointing to the potential of leveraging Hippo pathway transcriptional activation status as a metric by which patients may be meaningfully stratified. Preclinical models recapitulating disease are transformative in order to develop new therapeutic strategies. We here establish an isogenic cell-line model of PM, which represents the most frequently mutated genes and which faithfully recapitulates the molecular features of clinical PM. This preclinical model is developed to probe the molecular basis by which the Hippo pathway and key driver mutations affect cancer initiation and progression. Implementing this approach, we reveal the role of NF2 as a mechanosensory component of the Hippo pathway in mesothelial cells. Cellular NF2 loss upon physiological stiffnesses analogous to the tumour niche drive YAP/TAZ-dependent anchorage-independent growth. Consequently, the development and characterisation of this cellular model provide a unique resource to obtain molecular insights into the disease and progress new drug discovery programs together with future stratification of PM patients.},
}
@article {pmid36729166,
year = {2023},
author = {Slavik, CE and Demers, PA and Tamburic, L and Warden, H and McLeod, C},
title = {Do patterns of past asbestos use and production reflect current geographic variations of cancer risk?: mesothelioma in Ontario and British Columbia, Canada.},
journal = {Cancer causes &amp; control : CCC},
volume = {34},
number = {4},
pages = {349-360},
pmid = {36729166},
issn = {1573-7225},
support = {RS2018-SP27//WorkSafeBC/ ; },
mesh = {Humans ; British Columbia/epidemiology ; Ontario/epidemiology ; *Mesothelioma/epidemiology/etiology ; *Asbestos/adverse effects ; Environmental Exposure ; Incidence ; *Occupational Exposure/adverse effects ; },
abstract = {PURPOSE: Canada was a major global asbestos producer and consumer. Geographic patterns of Canadian asbestos use and mesothelioma, a highly fatal cancer linked to asbestos exposure, have not been previously reported. This study summarized key trends in mesothelioma incidence by geography and time in two Canadian provinces, Ontario and British Columbia (BC), and explored how past workforce characteristics and geographic trends in asbestos production and use may shape variations in regional rates of mesothelioma.<br><br>METHODS: We report trends in mesothelioma incidence (1993-2016) for Ontario and British Columbia using population-based incidence data that were age-standardized to the 2011 Canadian population. Historical records of asbestos production and use were analyzed to geo-locate industrial point sources of asbestos in Ontario and BC. The prevalence of occupations in regions with the highest and lowest rates of mesothelioma in Ontario and BC were calculated using labor force statistics from the 1981 Canadian Census.<br><br>RESULTS: Regional mesothelioma rates varied in both provinces over time; more census divisions in both Ontario and BC registered mesothelioma rates in the highest quintile of incidences during the period 2009 to 2016 than in any prior period examined. Certain occupations such as construction trades workers were more likely to be overrepresented in regions with high mesothelioma rates.<br><br>CONCLUSION: This work explored how studying asbestos exposure and mesothelioma incidence at small-scale geographies could direct cancer surveillance and research to more targeted areas. Findings indicated that regional variations in mesothelioma could signal important differences in past occupational and potentially environmental exposures.},
}
@article {pmid36724751,
year = {2023},
author = {Endo, I and Amatya, VJ and Kushitani, K and Nakagiri, T and Aoe, K and Takeshima, Y},
title = {miR-142-3p Suppresses Invasion and Adhesion of Mesothelioma Cells by Downregulating ITGAV.},
journal = {Pathobiology : journal of immunopathology, molecular and cellular biology},
volume = {90},
number = {4},
pages = {270-280},
doi = {10.1159/000528670},
pmid = {36724751},
issn = {1423-0291},
mesh = {Humans ; *Mesothelioma, Malignant/genetics ; Cell Movement/genetics ; Cell Line, Tumor ; *Mesothelioma/genetics ; *MicroRNAs/genetics/metabolism ; RNA, Small Interfering/metabolism ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; },
abstract = {INTRODUCTION: Malignant mesothelioma is an aggressive cancer associated with asbestos exposure. Currently, the efficacy of therapeutics is limited in malignant mesothelioma, and developing more effective therapies is the need of the hour. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), have attracted attention as therapeutic targets. To explore potential therapeutic targets, we focused on miR-142-3p expression, which was found to be significantly downregulated in mesothelioma cell lines in our previous study.<br><br>METHODS: Mesothelioma cell lines and tissues were validated for expression of miR-142-3p or integrin subunit alpha-V (ITGAV). We transfected mesothelioma cell lines with miR-142-3p mimic and ITGAV siRNA and analyzed their biological functions.<br><br>RESULTS: We found that miR-142-3p was significantly downregulated in mesothelioma tissues. Transfection with miR-142-3p mimic significantly suppressed cell proliferation, migration, and invasion. Bioinformatics analysis of potential targets of miR-142-3p identified ITGAV. Membrane ITGAV expression in mesothelioma cell lines was confirmed using immunocytochemistry. ITGAV was significantly upregulated in mesothelioma tissues. Moreover, transfection of miR-142-3p mimics into mesothelioma cell lines significantly suppressed ITGAV expression, indicating that miR-142-3p targets ITGAV. Next, ITGAV siRNA transfection into mesothelioma cell lines inhibited cell proliferation, migration, and invasion. Further investigation of cell adhesion mechanisms showed that the miR-142-3p/ITGAV axis specifically affects mesothelioma cell adhesion via vitronectin in the extracellular matrix.<br><br>CONCLUSION: This study proposed that the miR-142-3p/ITGAV axis is involved in tumor progression in malignant mesothelioma.},
}
@article {pmid36720634,
year = {2023},
author = {Del Monaco, A and Dimitriadis, C and Xie, S and Benke, G and Sim, MR and Walker-Bone, K},
title = {Workers in Australian prebake aluminium smelters: update on risk of mortality and cancer incidence in the Healthwise cohort.},
journal = {Occupational and environmental medicine},
volume = {80},
number = {3},
pages = {160-169},
doi = {10.1136/oemed-2022-108605},
pmid = {36720634},
issn = {1470-7926},
mesh = {Humans ; Male ; Aluminum/adverse effects ; Incidence ; Cohort Studies ; *Occupational Diseases/etiology ; Australia/epidemiology ; *Neoplasms ; *Mesothelioma/etiology ; *Lung Neoplasms ; Cause of Death ; *Mesothelioma, Malignant/complications ; *Occupational Exposure/adverse effects ; },
abstract = {OBJECTIVES: To investigate mortality and the rates of incident cancer among a cohort of aluminium industry workers.<br><br>METHODS: Among 4507 male employees who worked in either of two Australian prebake smelters for at least 3 months, data linkage was undertaken with the Australian National Death Index and Australian Cancer Database. Standardised Mortality Ratios (SMRs) and Standardised Incidence Rates (SIRs) were estimated for the whole cohort and for: production; maintenance and office workers. SMRs and SIRs were calculated by time since first employment.<br><br>RESULTS: Among production workers, there was an excess risk of mortality from mesothelioma (SMR 2.8, 95%&#x2009;CI 1.3 to 5.2), lung (SMR 1.4, 95%&#x2009;CI 1.0 to 1.8), prostate (SMR 1.9, 95%&#x2009;CI 1.3 to 2.7) and liver cancer (SMR 2.0, 95%&#x2009;CI 1.1 to 3.4) and the SIR was also increased for overall respiratory cancers, specifically lung cancers. An excess risk of death from stomach cancer (SMR 2.9, 95%&#x2009;CI 1.2 to 6.1) and Alzheimer's disease (SMR 3.4, 95%&#x2009;CI 1.1 to 7.9) was seen among maintenance workers. The overall risk of death was similar to that of the Australian general population, as was mortality from cancers overall and non-malignant respiratory disease.<br><br>CONCLUSIONS: No excess risk of death from bladder cancer or non-malignant respiratory disease was found. Excess lung cancer mortality and incidence may be explained by smoking and excess mortality from mesothelioma may be explained by asbestos exposure. An excess risk of mortality from liver and prostate cancer has been shown in production workers and requires further investigation.},
}
@article {pmid36705549,
year = {2022},
author = {Di Genova, A and Mangiante, L and Sexton-Oates, A and Voegele, C and Fernandez-Cuesta, L and Alcala, N and Foll, M},
title = {A molecular phenotypic map of malignant pleural mesothelioma.},
journal = {GigaScience},
volume = {12},
number = {},
pages = {},
pmid = {36705549},
issn = {2047-217X},
support = {001/WHO_/World Health Organization/International ; },
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/genetics/pathology ; *Lung Neoplasms/genetics/pathology ; *Pleural Neoplasms/genetics/pathology ; Phenotype ; },
abstract = {BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare understudied cancer associated with exposure to asbestos. So far, MPM patients have benefited marginally from the genomics medicine revolution due to the limited size or breadth of existing molecular studies. In the context of the MESOMICS project, we have performed the most comprehensive molecular characterization of MPM to date, with the underlying dataset made of the largest whole-genome sequencing series yet reported, together with transcriptome sequencing and methylation arrays for 120 MPM patients.<br><br>RESULTS: We first provide comprehensive quality controls for all samples, of both raw and processed data. Due to the difficulty in collecting specimens from such rare tumors, a part of the cohort does not include matched normal material. We provide a detailed analysis of data processing of these tumor-only samples, showing that all somatic alteration calls match very stringent criteria of precision and recall. Finally, integrating our data with previously published multiomic MPM datasets (n = 374 in total), we provide an extensive molecular phenotype map of MPM based on the multitask theory. The generated map can be interactively explored and interrogated on the UCSC TumorMap portal (https://tumormap.ucsc.edu/?p=RCG_MESOMICS/MPM_Archetypes).<br><br>CONCLUSIONS: This new high-quality MPM multiomics dataset, together with the state-of-art bioinformatics and interactive visualization tools we provide, will support the development of precision medicine in MPM that is particularly challenging to implement in rare cancers due to limited molecular studies.},
}
@article {pmid36687288,
year = {2023},
author = {Romano, M and Pinto, P and Afonso, R and Fontes, J and Ferreira, M},
title = {Pleural Mesothelioma: A Rapid Evolution of an Indolent Disease.},
journal = {Cureus},
volume = {15},
number = {1},
pages = {e33965},
pmid = {36687288},
issn = {2168-8184},
abstract = {Mesothelioma is a rare and insidious neoplasm and is characterized by its highly malignant and aggressive nature. The most common etiology is asbestos exposure, but there are some reports without known asbestos exposure and other factors leading to malignant pleural mesothelioma (MPM). Here, we present the case of a 58-year-old woman with pleuritic chest pain, dyspnea, and fever on presentation to the emergency department (ED), which caused several admissions to the ED in 20 days. The patient was then admitted to the internal medicine department with a diagnosis of community-acquired pneumonia with parapneumonic effusion. During hospitalization, a positron emission tomography (PET) scan, thoracic computed tomography (CT), and pleural biopsy were performed and a final diagnosis of malignant epithelioid pleural mesothelioma was made. Six weeks after the onset of symptoms, the patient presented with an exponential disease progression, dying two months after the diagnosis, despite the initiation of chemotherapy. MPM remains a diagnostic and therapeutic challenge with a very poor prognosis. However, studies show that mesothelioma patients who undergo treatment live at least twice as long as patients who do not receive treatment. This case report is particularly significant because, although it was epithelioid mesothelioma, multiple solid masses were noted on CT and the patient exhibited rapid disease progression, dying a few weeks after starting treatment.},
}
@article {pmid36673690,
year = {2023},
author = {Magnani, C and Mensi, C and Binazzi, A and Marsili, D and Grosso, F and Ramos-Bonilla, JP and Ferrante, D and Migliore, E and Mirabelli, D and Terracini, B and Consonni, D and Degiovanni, D and Lia, M and Cely-García, MF and Giraldo, M and Lysaniuk, B and Comba, P and Marinaccio, A},
title = {The Italian Experience in the Development of Mesothelioma Registries: A Pathway for Other Countries to Address the Negative Legacy of Asbestos.},
journal = {International journal of environmental research and public health},
volume = {20},
number = {2},
pages = {},
pmid = {36673690},
issn = {1660-4601},
mesh = {Female ; Humans ; *Lung Neoplasms/epidemiology ; *Asbestos/toxicity ; *Mesothelioma/epidemiology/etiology ; *Mesothelioma, Malignant ; *Carcinogens, Environmental ; Registries ; Italy/epidemiology ; },
abstract = {Asbestos (all forms, including chrysotile, crocidolite, amosite, tremolite, actinolite, and anthophyllite) is carcinogenic to humans and causally associated with mesothelioma and cancer of the lung, larynx, and ovary. It is one of the carcinogens most diffuse in the world, in workplaces, but also in the environment and is responsible for a very high global cancer burden. A large number of countries, mostly with high-income economies, has banned the use of asbestos which, however, is still widespread in low- and middle-income countries. It remains, thus, one of the most common occupational and environmental carcinogens worldwide. Italy issued an asbestos ban in 1992, following the dramatic observation of a large increase in mortality from mesothelioma and other asbestos-related diseases in exposed workers and also in subjects with non-occupational exposure. A mesothelioma registry was also organized and still monitors the occurrence of mesothelioma cases, conducting a case-by-case evaluation of asbestos exposure. In this report, we describe two Italian communities, Casale Monferrato and Broni, that faced an epidemic of mesothelioma resulting from the production of asbestos cement and the diffuse environmental exposure; we present the activity and results of the Italian mesothelioma registry (ReNaM), describe the risk-communication activities at the local and national level with a focus on international cooperation and also describe the interaction between mesothelioma registration and medical services specialized in mesothelioma diagnosis and treatment in an area at high risk of mesothelioma. Finally, we assess the potential application of the solutions and methods already developed in Italy in a city in Colombia with high mesothelioma incidence associated with the production of asbestos-cement materials and the presence of diffuse environmental asbestos pollution.},
}
@article {pmid36653798,
year = {2023},
author = {Moline, J and Patel, K and Frank, AL},
title = {Exposure to cosmetic talc and mesothelioma.},
journal = {Journal of occupational medicine and toxicology (London, England)},
volume = {18},
number = {1},
pages = {1},
pmid = {36653798},
issn = {1745-6673},
abstract = {AIM: Mesothelioma is associated with asbestos exposure. In this case series, we present 166 cases of individuals who had substantial asbestos exposure to cosmetic talc products as well as some who had potential or documented additional exposures to other asbestos-containing products and who subsequently developed mesothelioma.<br><br>METHODS: Data were gathered for all subjects referred to an occupational and environmental medicine specialist as part of medicolegal review. Years of total cosmetic talcum powder usage was noted as well as the latency from the onset of talcum powder use to the mesothelioma diagnosis. Alternate asbestos exposure in addition to the exposure from cosmetic talc was categorized as none, possible, likely, and definite.<br><br>RESULTS: In 122 cases, the only known exposure to asbestos was from cosmetic talc. For 44 cases, potential or documented alternate exposures in addition to the cosmetic talc were described.<br><br>CONCLUSION: Cumulative exposure to asbestos leads to mesothelioma; for individuals with mixed exposures to asbestos, all exposures should be considered. Use of cosmetic talc is often overlooked as a source of asbestos exposure. All individuals with mesothelioma should have a comprehensive history of asbestos exposure, including cosmetic talc exposure.},
}
@article {pmid36646495,
year = {2022},
author = {Piao, ZH and Zhou, XC and Zhang, X},
title = {[Updates in the pathological diagnosis of Pleural Malignant Mesothelioma in the WHO classification of thoracic tumors (5(th) edition)].},
journal = {Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases},
volume = {40},
number = {12},
pages = {956-960},
doi = {10.3760/cma.j.cn121094-20211105-00546},
pmid = {36646495},
issn = {1001-9391},
support = {2022-F30//China-Japan Project for the Improvement of Diagnosis of Asbestos-related Cancer/ ; //Project of NiNGBO leading Medical &amp; Health Discipline/ ; },
mesh = {Humans ; *Mesothelioma, Malignant ; *Pleural Neoplasms/diagnosis ; *Mesothelioma/diagnosis ; Prognosis ; World Health Organization ; *Lung Neoplasms/diagnosis/pathology ; },
abstract = {The WHO Classification of Thoracic Tumors (5(th) edition) mainly has the following changes in the chapter of pleural malignant mesothelioma. (1) The concept of mesothelioma in situ and its diagnostic method have been established for the first time; (2) The tumour grading of pleural malignant mesothelioma was added, it was divided into low grade and high grade according to the cellular atypia, mitotic activity and presence of necrosis. (3) The morphological features of pleural malignant mesothelioma was classified into architectural pattern, cellular and stromal features, the correlation between histological features and prognosis was refined, and some of the controversial cellular types have been reclassified. In this review, we introduced the changes of related pathologic diagnosis, in the WHO Classification of Thoracic Tumors (5(th) edition) and discussed its clinical significance.},
}
@article {pmid36636687,
year = {2022},
author = {Neff, D and Padberg Sgier, BC and Dietze, H and Müller, J and Früh, M},
title = {Unusually Aggressive Presentation of Malignant Peritoneal Mesothelioma: Two Case Reports.},
journal = {Case reports in oncology},
volume = {15},
number = {3},
pages = {1001-1008},
pmid = {36636687},
issn = {1662-6575},
abstract = {Malignant peritoneal mesothelioma is a rare disease. Patients mainly present with abdominal distension, pain, nausea, and weight loss with or without an exposure history of asbestos. Diagnosis may be difficult from a clinical and histopathologic perspective. Treatment options are surgery in early stages, radiotherapy and/or intraperitoneal or systemic therapy. Prognosis depends on TNM stage and histologic subtype with epithelioid subtype being the most favorable one but in general remains poor. We present a 59-year-old male (patient 1) and a 79-year-old female (patient 2) with progressive dyspnea. PET-CT of patient 1 revealed metastatic spread in the pleura and extensive peritoneal carcinomatosis. PET-CT of patient 2 displayed FDG-avid lymph nodes on both sides of the diaphragm, polyserositis, and FDG uptake along the peritoneum. Both patients were eventually diagnosed with malignant peritoneal mesothelioma. Patient 1 was treated with carboplatin and gemcitabine, and patient 2 received no systemic therapy. Even though the epithelioid subtype was found, both patients succumbed due to rapid tumor progression in a matter of a few weeks only. Presentation with polyserositis even in the absence of relevant asbestos exposure may represent malignant peritoneal mesothelioma if ascites is present, and rapid invasive diagnostic (excision biopsy) should be performed. These two unusual cases emphasize that even in epithelioid subtype, clinicians ought to be aware of possible rapid clinical deterioration, and timely diagnosis with initiation of therapy is crucial. Further research is necessary to better understand tumor biology, establish predictive markers, and develop new treatment options.},
}
@article {pmid36636360,
year = {2022},
author = {Dusseault, SK and Okobi, OE and Thakral, N and Sankar, V and Gunawardene, I and Dawkins, B and Abu, Y and Davis, B},
title = {Primary Peritoneal Mesothelioma: Diagnostic Challenges of This Lethal Imposter.},
journal = {Case reports in gastroenterology},
volume = {16},
number = {3},
pages = {588-594},
pmid = {36636360},
issn = {1662-0631},
abstract = {Primary Peritoneal Mesothelioma is a rapidly aggressive and rare neoplasm that arises from the lining of mesothelial cells of the peritoneum and spreads extensively within the confines of the abdominal cavity. The pathogenesis of all forms of mesothelioma is strongly associated with industrial pollutants, of which asbestos is the principal carcinogen. Characteristically, asbestos exposure has a strong relationship with mesothelioma of the pleura, but the peritoneal cavity is the second most commonly affected site. Additionally, in contrast to pleural mesothelioma, which has a male predominance (male-female ratio of between four and five to one), women comprise approximately one-half of all cases of malignant peritoneal mesothelioma. A thorough history of occupational/paraoccupational exposure along with histopathology is the key to timely diagnosis and treatment.},
}
@article {pmid36635096,
year = {2023},
author = {Kurth, L and Mazurek, JM and Blackley, DJ},
title = {Malignant mesothelioma among US Medicare beneficiaries: incidence, prevalence and therapy, 2016-2019.},
journal = {Occupational and environmental medicine},
volume = {80},
number = {2},
pages = {86-92},
pmid = {36635096},
issn = {1470-7926},
support = {CC999999/ImCDC/Intramural CDC HHS/United States ; },
mesh = {Humans ; Aged ; United States/epidemiology ; *Medicare ; *Mesothelioma, Malignant ; Prevalence ; Incidence ; Fee-for-Service Plans ; },
abstract = {OBJECTIVES: Mesothelioma is a rare, aggressive cancer caused by exposure to asbestos fibres. Mesothelioma patients who receive trimodal therapy (chemotherapy, surgical resection and radiation) survive longer than those who receive two or fewer therapy modalities. This study analyses the 2016-2019 Medicare claims data to estimate the burden of malignant mesothelioma and describe therapy patterns (when available) among continuously enrolled fee-for-service (FFS; Medicare parts A and B) beneficiaries.<br><br>METHODS: We analysed claims and enrolment information from 42 529 117 FFS Medicare beneficiaries using three mesothelioma case definitions (broad, intermediate and narrow) with varying levels of diagnostic requirements. Results are presented as ranges of values for the three definitions.<br><br>RESULTS: Among FFS beneficiaries, 8213-19&#x2009;036 beneficiaries with mesothelioma were identified depending on the case definition. The annual prevalence per 100&#x2009;000 beneficiaries ranged from 8.8 in 2016 (narrow) to 31.3 in 2019 (broad) and annual incidence per 100&#x2009;000 beneficiaries ranged from 4.5 in 2019 (narrow) to 12.6 in 2017 (broad). Depending on the mesothelioma case definition, 41.8%-81.5% had available therapy claim information indicating that 7.6%-11.3% received chemotherapy alone, 1.3%-1.5% received radiation alone, and 14.3%-27.0% underwent surgery only, with 4.6%-10.5% receiving all three therapy modalities.<br><br>CONCLUSIONS: Mesothelioma was a prevalent disease among FFS Medicare beneficiaries during 2016-2019, and a limited proportion of beneficiaries received all three therapy modalities. Medicare data build on findings from cancer registry data to enhance our understanding of the mesothelioma burden and therapy patterns.},
}
@article {pmid36630203,
year = {2023},
author = {Caceres, JD and Venkata, AN},
title = {Asbestos-associated pulmonary disease.},
journal = {Current opinion in pulmonary medicine},
volume = {29},
number = {2},
pages = {76-82},
pmid = {36630203},
issn = {1531-6971},
mesh = {Humans ; *Mesothelioma/etiology/pathology ; *Asbestos/toxicity ; *Pleural Diseases/diagnostic imaging/etiology ; *Lung Diseases/complications ; *Asbestosis/complications/diagnostic imaging/pathology ; *Pleural Effusion/etiology ; *Lung Neoplasms/chemically induced ; *Mesothelioma, Malignant/complications ; },
abstract = {PURPOSE OF REVIEW: Exposure to asbestos can cause both benign and malignant, pulmonary and pleural diseases. In the current era of low asbestos exposure, it is critical to be aware of complications from asbestos exposure; as they often arise after decades of exposure, asbestos-related pulmonary complications include asbestosis, pleural plaques, diffuse pleural thickening, benign asbestos-related pleural effusions and malignant pleural mesothelioma.<br><br>RECENT FINDINGS: Multiple recent studies are featured in this review, including a study evaluating imaging characteristics of asbestos with other fibrotic lung diseases, a study that quantified pleural plaques on computed tomography imaging and its impact on pulmonary function, a study that examined the risk of lung cancer with pleural plaques among two large cohorts and a review of nonasbestos causes of malignant mesothelioma.<br><br>SUMMARY: Asbestos-related pulmonary and pleural diseases continue to cause significant morbidity and mortality. This review summarizes the current advances in this field and highlights areas that need additional research.},
}
@article {pmid36622824,
year = {2022},
author = {Moscadelli, A and Martini, A and Angelini, A and Baldassarre, A and Lorini, C and Bonaccorsi, G and Cacciarini, V and Rosselli, A and Chellini, E},
title = {[Mortality study in a cohort of entertainment workers].},
journal = {Giornale italiano di medicina del lavoro ed ergonomia},
volume = {44},
number = {3},
pages = {360-359},
pmid = {36622824},
issn = {1592-7830},
mesh = {Humans ; Male ; Female ; Cohort Studies ; *Mesothelioma ; *Occupational Diseases/etiology ; Cause of Death ; *Asbestos ; *Occupational Exposure/adverse effects ; },
abstract = {Introduction. Malignant mesotheliomas have been observed in entertainment workers in the last decades. They have been evaluated as occupationally exposed to asbestos contained in tools used for fireproof and sound-absorbing purposes. Aim of the study. To evaluate the mortality of workers engaged in a Florentine theatre where a large quantity of asbestos was found in the '80s, put in place 20 years earlier. Methods. It is a cohort study on entertainment workers with follow-up period ranged from 1-1-1970 till 31-12-2018. Standardized Mortality Ratios (SMRs) and their 95% Confidence Intervals (95% IC) were calculated by gender and job ("manual workers" and "all other jobs"), using age and sex specific mortality rates of Tuscan population. Results. The cohort includes 826 workers (389 manual workers and 437 engaged in other jobs) engaged by the Florentine theatre between 01/01/1937 and 31/12/1990. Excesses of mortality for all causes are observed in manual workers, either males (301 cases; SMR 304,0; 95% IC 271,5-340,3) or females (86 cases; SMR 429,8; 95% IC 348,0-531,0). The group of the other workers presents deficits of mortality by all causes, cancers and cardiovascular diseases in both genders. One death for pleural cancer is observed in a manual worker. Discussion. The results are in line with previous observations in similar occupations. In the examined Florentine theatre the asbestos exposures were important only for the manual workers who worked in the technical rooms characterized by the presence of friable asbestos sprinkled and in a bad state of maintenance.},
}
@article {pmid36612385,
year = {2022},
author = {Mutetwa, B and Moyo, D and Brouwer, D},
title = {Prediction of Asbestos-Related Diseases (ARDs) and Chrysotile Asbestos Exposure Concentrations in Asbestos-Cement (AC) Manufacturing Factories in Zimbabwe.},
journal = {International journal of environmental research and public health},
volume = {20},
number = {1},
pages = {},
pmid = {36612385},
issn = {1660-4601},
mesh = {Humans ; Asbestos, Serpentine/toxicity ; *Asbestosis/epidemiology ; Zimbabwe/epidemiology ; *Asbestos ; *Mesothelioma/epidemiology ; *Lung Neoplasms/epidemiology ; *Occupational Exposure ; *Mesothelioma, Malignant ; },
abstract = {The use of historical asbestos measurement data in occupational exposure assessment is essential as it allows more quantitative analysis of possible exposure response relationships in asbestos-related disease (ARD) occurrence. The aim of this study was to predict possible ARDs, namely lung cancer, mesothelioma, gastrointestinal cancer, and asbestosis, in two chrysotile asbestos cement (AC) manufacturing factories. Prediction of ARDs was done using a specific designed job-exposure matrix for airborne chrysotile asbestos fibre concentrations obtained from the Harare and Bulawayo AC factories and through application of OSHA's linear dose effect model in which ARDs were estimated through extrapolation at 1, 10, 20, and 25 years of exposure. The results show that more cancer and asbestosis cases are likely to be experienced among those exposed before 2008 as exposure levels and subsequently cumulative exposure were generally much higher than those experienced after 2008. After a possible exposure period of 25 years, overall cancer cases predicted in the Harare factory were 325 cases per 100,000 workers, while for the Bulawayo factory, 347 cancer cases per 100,000 workers exposed may be experienced. Possible high numbers of ARDs are likely to be associated with specific tasks/job titles, e.g., saw cutting, kollergang, fettling table, ground hard waste, and possibly pipe-making operations, as cumulative exposures, though lower than reported in other studies, may present higher risk of health impairment. The study gives insights into possible ARDs, namely lung cancer, mesothelioma, gastrointestinal cancer, and asbestosis, that may be anticipated at various cumulative exposures over 1, 10, 20, and 25 years of exposure in AC manufacturing factories in Zimbabwe. Additionally, results from the study can also form a basis for more in-depth assessment of asbestos cancer morbidity studies in the AC manufacturing industries.},
}
@article {pmid36612122,
year = {2022},
author = {Casalone, E and Birolo, G and Pardini, B and Allione, A and Russo, A and Catalano, C and Mencoboni, M and Ferrante, D and Magnani, C and Sculco, M and Dianzani, I and Grosso, F and Mirabelli, D and Filiberti, RA and Rena, O and Sacerdote, C and Rodriguez-Barranco, M and Smith-Byrne, K and Panico, S and Agnoli, C and Johnson, T and Kaaks, R and Tumino, R and Huerta, JM and Riboli, E and Heath, AK and Trobajo-Sanmartín, C and Schulze, MB and Saieva, C and Amiano, P and Agudo, A and Weiderpass, E and Vineis, P and Matullo, G},
title = {Serum Extracellular Vesicle-Derived microRNAs as Potential Biomarkers for Pleural Mesothelioma in a European Prospective Study.},
journal = {Cancers},
volume = {15},
number = {1},
pages = {},
pmid = {36612122},
issn = {2072-6694},
support = {001/WHO_/World Health Organization/International ; MR/S019669/1/MRC_/Medical Research Council/United Kingdom ; },
abstract = {Malignant pleural mesothelioma (MPM) is an aggressive cancer with a dismal prognosis. Early therapeutic interventions could improve patient outcomes. We aimed to identify a pattern of microRNAs (miRNAs) as potential early non-invasive markers of MPM. In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort, we screened the whole miRNome in serum extracellular vesicles (EVs) of preclinical MPM cases. In a subgroup of 20 preclinical samples collected five years prior MPM diagnosis, we observed an upregulation of miR-11400 (fold change (FC) = 2.6, adjusted p-value = 0.01), miR-148a-3p (FC = 1.5, p-value = 0.001), and miR-409-3p (FC = 1.5, p-value = 0.04) relative to matched controls. The 3-miRNA panel showed a good classification capacity with an area under the receiver operating characteristic curve (AUC) of 0.81 (specificity = 0.75, sensitivity = 0.70). The diagnostic ability of the model was also evaluated in an independent retrospective cohort, yielding a higher predictive power (AUC = 0.86). A signature of EV miRNA can be detected up to five years before MPM; moreover, the identified miRNAs could provide functional insights into the molecular changes related to the late carcinogenic process, preceding MPM development.},
}
@article {pmid36601180,
year = {2022},
author = {Mankidy, B and Sparkman, J and Boddu, S and Huang, Q and Sharma, M},
title = {Simultaneous Use of Endobronchial and Endoscopic Ultrasound Guidance as Primary Tools in the Diagnosis of Malignant Pleural Mesothelioma.},
journal = {Cureus},
volume = {14},
number = {12},
pages = {e32110},
pmid = {36601180},
issn = {2168-8184},
abstract = {Malignant pleural mesothelioma (MPM) is related to exposure to asbestos. It is insidious in nature and is generally diagnosed at an advanced stage. MPM is aggressive and portends a poor prognosis. Definitive diagnosis is usually established by obtaining pathological samples of the pleura by medical or surgical thoracoscopy. However, these procedures are invasive and carry a risk of seeding of biopsy sites with tumors. We herein report an infrequently encountered case of simultaneous use of endobronchial ultrasound and endoscopic ultrasound-guided biopsy of malignant pleural mesothelioma in a 48-year-old female patient.},
}
@article {pmid38299094,
year = {2023},
author = {Alratrout, H and Boumarah, DN and Alghusnah, ES and Alabbad, A and Alsaffar, AH and Alsafwani, NS and Foula, MS},
title = {Synchronous Malignant Peritoneal Mesothelioma and Sigmoid Adenocarcinoma: a Challenging Clinical Entity.},
journal = {Medical archives (Sarajevo, Bosnia and Herzegovina)},
volume = {77},
number = {5},
pages = {400-404},
pmid = {38299094},
issn = {1986-5961},
mesh = {Humans ; Female ; Aged ; *Mesothelioma/diagnosis/pathology/surgery ; *Mesothelioma, Malignant ; *Peritoneal Neoplasms/diagnosis ; *Colonic Neoplasms/diagnosis ; *Adenocarcinoma/diagnosis/surgery ; },
abstract = {BACKGROUND: Malignant peritoneal mesothelioma (MPM) represents a rare clinical entity. The synchronous existence of MPM with other malignancies as colonic adenocarcinoma have been rarely reported. Its diagnosis and management are challenging given its complexity and rarity.<br><br>OBJECTIVE: Herein, we report a case of epithelioid subtype of MPM occurring synchronously with sigmoid colonic adenocarcinoma, along with review of the literature.<br><br>CASE PRESENTATION: An elderly female patient was referred as case of rectosigmoid mass. She reported history of abdominal pain, per-rectal bleeding, anorexia, and significant weight loss. Her computed-tomography scan of the abdomen revealed a fistulizing sigmoid mass and multiple enlarged lymphnodes with omental nodulation. The colonoscopy revealed a large fungating mass and the endoscopic biopsies were reported as colonic adenocarcinoma. The patient was scheduled laparoscopic low anterior resection. However, the diagnostic laparoscopy revealed several nodules disseminated all over the peritoneum, suggestive of peritoneal mesothelioma. Therefore, the decision was changed to create transverse colostomy after examination obtaining multiple biopsies from the omental and peritoneal nodules. The histopathological revealed MPM and the final diagnosis was sigmoid adenocarcinoma with synchronous MPM. The patient was started on palliative chemotherapy (capecitabine) without active management of MPM because of her general condition. She was followed up with a good clinical course.<br><br>CONCLUSION: MPM is an overlooked entity with vague clinical presentation. Synchronous MPM with colorectal cancer is rare with only few published case reports. Its diagnosis is challenging, and its management should be tailored according to the patient. This case is the first reported case in Saudi Arabia and the Middle East.},
}
@article {pmid36556334,
year = {2022},
author = {Caraballo-Arias, Y and Zunarelli, C and Caffaro, P and Roccuzzo, F and Nocilla, MR and Imperiale, MC and Romano, C and Boffetta, P and Violante, FS},
title = {Quantitative Assessment of Asbestos Fibers in Normal and Pathological Peritoneal Tissue-A Scoping Review.},
journal = {Life (Basel, Switzerland)},
volume = {12},
number = {12},
pages = {},
pmid = {36556334},
issn = {2075-1729},
abstract = {Peritoneal tissue is the second most affected site by malignant mesothelioma linked to asbestos exposure. This scoping review aims to summarize the findings of the studies in which asbestos fibers in the peritoneum were quantified by electron microscopy, occasionally associated with spectroscopy, both in neoplastic and non-neoplastic tissue. The 9 studies selected comprised 62 cases, out of whom 100 samples were analyzed. Asbestos fibers were detected in 58 samples (58%). In addition, 28 cases had diagnosis of peritoneal mesothelioma. For 32 cases, a lung tumor sample was available: 28/32 samples analyzed presented asbestos fibers; 18/32 reported amphiboles with a range from not detected to 14.2 million fibers per gram of dry tissue (mfgdt); 18/32 reported chrysotile, with a range of 0 to 90 mfgdt. The studies were heterogeneous for type of samples, analytical technology, and circumstances of exposure to asbestos. To evaluate asbestos fibers in the peritoneum and to better understand the association between asbestos exposure and malignant peritoneal mesothelioma, it is desirable that the search for asbestos fibers becomes a routine process every time peritoneal tissue is accessible.},
}
@article {pmid36554530,
year = {2022},
author = {Gardner, M and Cross, M and Reed, S and Davidson, M and Hughes, R and Oosthuizen, J},
title = {Pathogenic Potential of Respirable Spodumene Cleavage Fragments following Application of Regulatory Counting Criteria for Asbestiform Fibres.},
journal = {International journal of environmental research and public health},
volume = {19},
number = {24},
pages = {},
pmid = {36554530},
issn = {1660-4601},
mesh = {Humans ; Minerals ; *Mesothelioma ; *Mesothelioma, Malignant ; *Lung Neoplasms ; *Occupational Exposure ; },
abstract = {Health risks from exposure to lithium-bearing spodumene cleavage fragments are unknown. While asbestiform fibres can lead to fibrosis, mesothelioma and lung cancer, controversy remains whether non-asbestiform cleavage fragments, having equivalent dimensions, elicit similar pathologic responses. The mineralogy of respirable particles from two alpha (α)-spodumene concentrate grades (chemical and technical) were characterised using semi-quantitative X-ray diffraction (XRD). Particles were measured using scanning electron microscopy (SEM) and the dimensions (length [L], diameter [D], aspect ratio [AR]) applied to regulatory counting criteria for asbestiform fibres. Application of the current World Health Organization (WHO) and National Occupational Health and Safety Commission (NOHSC) counting criteria, L ˃ 5 µm, D ˂ 3 µm, AR ˃ 3:1, to 10 SEM images of each grade identified 47 countable particles in the chemical and 37 in the technical concentrate test samples. Of these particles, 17 and 16 in the chemical and technical test samples, respectively, satisfied the more rigorous, previously used Mines Safety and Inspection Regulations 1995 (Western Australia [WA]) criteria, L ˃ 5 µm and D ≤ 1 µm. The majority of the countable particles were consistent with α-spodumene cleavage fragments. These results suggest elongated α-spodumene particles may pose a health risk. It is recommended the precautionary principle be applied to respirable α-spodumene particles and the identification and control of dust hazards in spodumene extraction, handling and processing industries be implemented.},
}
@article {pmid36553016,
year = {2022},
author = {Moro, J and Sobrero, S and Cartia, CF and Ceraolo, S and Rapanà, R and Vaisitti, F and Ganio, S and Mellone, F and Rudella, S and Scopis, F and La Paglia, D and Cacciatore, CC and Ruffini, E and Leo, F},
title = {Diagnostic and Therapeutic Challenges of Malignant Pleural Mesothelioma.},
journal = {Diagnostics (Basel, Switzerland)},
volume = {12},
number = {12},
pages = {},
pmid = {36553016},
issn = {2075-4418},
abstract = {Malignant pleural mesothelioma is a rare cancer characterized by a very poor prognosis. Exposure to asbestos is the leading cause of malignant pleural mesothelioma. The preinvasive lesions, the mesothelial hyperplasia and its possible evolution are the focus of the majority of the studies aiming to identify the treatable phase of the disease. The role of BAP-1 and MTAP in the diagnosis of mesothelioma in situ and in the prognosis of malignant pleural mesothelioma is the main topic of recent studies. The management of preinvasive lesions in mesothelioma is still unclear and many aspects are the subject of debate. The diagnosis, the disease staging and the accurate, comprehensive assessment of patients are three key instants for an appropriate management of patients/the disease.},
}
@article {pmid36552335,
year = {2022},
author = {Rihs, HP and Casjens, S and Raiko, I and Kollmeier, J and Lehnert, M and Nöfer, K and May-Taube, K and Kaiser, N and Taeger, D and Behrens, T and Brüning, T and Johnen, G and , },
title = {Mesothelin Gene Variants Affect Soluble Mesothelin-Related Protein Levels in the Plasma of Asbestos-Exposed Males and Mesothelioma Patients from Germany.},
journal = {Biology},
volume = {11},
number = {12},
pages = {},
pmid = {36552335},
issn = {2079-7737},
abstract = {Malignant mesothelioma (MM) is a severe disease mostly caused by asbestos exposure. Today, one of the best available biomarkers is the soluble mesothelin-related protein (SMRP), also known as mesothelin. Recent studies have shown that mesothelin levels are influenced by individual genetic variability. This study aimed to investigate the influence of three mesothelin (MSLN) gene variants (SNPs) in the 5′-untranslated promoter region (5′-UTR), MSLN rs2235503 C > A, rs3764246 A > G, rs3764247 A > C, and one (rs1057147 G > A) in the 3′-untranslated region (3′-UTR) of the MSLN gene on plasma concentrations of mesothelin in 410 asbestos-exposed males without cancer and 43 males with prediagnostic MM (i.e., with MM diagnosed later on) from the prospective MoMar study, as well as 59 males with manifest MM from Germany. The mesothelin concentration differed significantly between the different groups (p < 0.0001), but not between the prediagnostic and manifest MM groups (p = 0.502). Five to eight mutations of the four SNP variants studied were associated with increased mesothelin concentrations (p = 0.001). The highest mesothelin concentrations were observed for homozygous variants of the three promotor SNPs in the 5′-UTR (p < 0.001), and the highest odds ratio for an elevated mesothelin concentration was observed for MSLN rs2235503 C > A. The four studied SNPs had a clear influence on the mesothelin concentration in plasma. Hence, the analysis of these SNPs may help to elucidate the diagnostic background of patients displaying increased mesothelin levels and might help to reduce false-positive results when using mesothelin for MM screening in high-risk groups.},
}
@article {pmid36543384,
year = {2022},
author = {Chimed-Ochir, O and Rath, EM and Kubo, T and Yumiya, Y and Lin, RT and Furuya, S and Brislane, K and Klebe, S and Nowak, AK and Kang, SK and Takahashi, K},
title = {Must countries shoulder the burden of mesothelioma to ban asbestos? A global assessment.},
journal = {BMJ global health},
volume = {7},
number = {12},
pages = {},
pmid = {36543384},
issn = {2059-7908},
mesh = {Humans ; Shoulder ; *Mesothelioma/epidemiology/etiology ; *Asbestos/adverse effects ; Policy ; Global Burden of Disease ; },
abstract = {INTRODUCTION: Mesothelioma is a key asbestos-related disease (ARD) but can be difficult to diagnose. Countries presumably ban asbestos to reduce future ARD burdens, but it is unknown if countries ban asbestos as a consequence of ARD burdens. We assessed if and to what extent mesothelioma burden has an impact on a country banning asbestos and obtaining targets for preventative strategies.<br><br>METHODS: We analysed the status of asbestos ban and mesothelioma burden during 1990-2019 in 198 countries. We assessed mesothelioma burden by age-adjusted mortality rates (MRs) estimated by the Global Burden of Disease Study (GBD) and mesothelioma identification by the WHO mortality database. For GBD-estimated mesothelioma MR, the pre-ban period in the asbestos-banned countries was compared with the 1990-2019 period in the not-banned countries. For mesothelioma identification, the 1990-2019 period was applied to both banned and not-banned countries.<br><br>RESULTS: The association of mesothelioma MR with ban status increased as the ban year approached. Logistic regression analyses showed that the odds of a country banning asbestos increased 14.1-fold (95% CI 5.3 to 37.9) for mesothelioma identification combined with a 26% (12% to 42%) increase per unit increase of mesothelioma MR (one death per million per year) during the period 1-5&#x2009;year before ban (model p<0.0001).<br><br>CONCLUSION: Mesothelioma burden had an impact on, and together with its identification, explained the banning of asbestos in many countries. Asbestos-banned countries likely learnt lessons from their historical policies of using asbestos because mesothelioma burden and identification follow historical asbestos use. Prevention targets for ARD elimination should combine asbestos ban with mesothelioma identification.},
}
@article {pmid36541514,
year = {2023},
author = {Luo, Y and Akatsuka, S and Motooka, Y and Kong, Y and Zheng, H and Mashimo, T and Imaoka, T and Toyokuni, S},
title = {BRCA1 haploinsufficiency impairs iron metabolism to promote chrysotile-induced mesothelioma via ferroptosis resistance.},
journal = {Cancer science},
volume = {114},
number = {4},
pages = {1423-1436},
pmid = {36541514},
issn = {1349-7006},
support = {JP16H06276 [AdAMS]//Japan Society for the Promotion of Science/ ; JP21H03601//Japan Society for the Promotion of Science/ ; JP19H05462//Japan Society for the Promotion of Science/ ; JP20H05502//Japan Society for the Promotion of Science/ ; JP16H06276//Japan Society for the Promotion of Science/ ; JPMJCR19H4//Core Research for Evolutional Science and Technology/ ; SPRING JPMJSP2125//Japan Science and Technology Agency/ ; },
mesh = {Animals ; Female ; Male ; Rats ; *Asbestos/toxicity ; Asbestos, Crocidolite/toxicity ; Asbestos, Serpentine/toxicity ; BRCA1 Protein/genetics ; Carcinogenesis/genetics ; Comparative Genomic Hybridization ; DNA ; Ferric Compounds/metabolism ; *Ferroptosis/genetics ; Haploinsufficiency ; Iron/metabolism ; *Lung Neoplasms/chemically induced/genetics ; *Mesothelioma, Malignant/chemically induced/genetics ; },
abstract = {Malignant mesothelioma (MM) is still a social burden associated with asbestos exposure. Local iron accumulation thereby represents the major pathogenesis, followed by oxidative DNA strand breaks and genomic alterations in the mesothelium. BRCA1 is a critical component of homologous recombination repair directed to DNA double-stranded breaks, whereas BRCA1 germline mutation is an established risk for breast/ovarian cancer, its role in MM development remains to be elucidated. Murine Brca1 mutant models so far have not reproduced human phenotypes. However, a rat Brca1 mutant model (Mut; L63X/+) recently reproduced them at least partially. Here we describe the differential induction of MM in Brca1 mutant rats by intraperitoneal injection of chrysotile or crocidolite. Only Mut males injected with chrysotile revealed a promotional effect on mesothelial carcinogenesis in comparison with wild-type and/or females, with all the MMs Brca1 haploinsufficient. Array-based comparative genomic hybridization of MMs disclosed a greater extent of chromosomal deletions in Brca1 mutants, including Cdkn2a/2b accompanied by Tfr2 amplification, in comparison with wild-type tumors. Mutant MMs indicated iron metabolism dysregulation, such as an increase in catalytic Fe(II) and Ki67-index as well as a decrease in Fe(III) and ferritin expression. Simultaneously, mutant MMs revealed ferroptosis resistance by upregulation of Slc7A11 and Gpx4. At an early carcinogenic stage of 4 weeks, induced Brca1 expression in mesothelial cells was significantly suppressed in chrysotile/Mut in comparison with crocidolite/Mut, whereas significant preference to iron with a decrease in Fe(III) has been already established. In conclusion, chrysotile exposure can be a higher risk for MM in BRCA1 mutant males, considering the rat results.},
}
@article {pmid36525994,
year = {2023},
author = {Gazzano, E and Petriglieri, JR and Aldieri, E and Fubini, B and Laporte-Magoni, C and Pavan, C and Tomatis, M and Turci, F},
title = {Cytotoxicity of fibrous antigorite from New Caledonia.},
journal = {Environmental research},
volume = {230},
number = {},
pages = {115046},
doi = {10.1016/j.envres.2022.115046},
pmid = {36525994},
issn = {1096-0953},
mesh = {Humans ; Mice ; Animals ; *Asbestos, Serpentine/toxicity ; New Caledonia ; *Asbestos/toxicity ; Minerals/toxicity ; Silicates ; },
abstract = {Exposure to asbestos and asbestos-like minerals has been related to the development of severe lung diseases, including cancer and malignant mesothelioma (MM). A high incidence of non-occupational MM was observed in New Caledonia (France) in people living in proximity of serpentinite outcrops, containing chrysotile and fibrous antigorite. Antigorite is a magnesium silicate, which shares with chrysotile asbestos the chemical formula. To achieve information on antigorite toxicity, we investigated the physico-minero-chemical features relevant for toxicity and cellular effects elicited on murine macrophages (MH-S) and alveolar epithelial cells (A549) of three fibrous antigorites (f-Atg) collected in a Caledonian nickel lateritic ore and subjected to supergene alteration. Field Atg were milled to obtain samples suitable for toxicological studies with a similar particle size distribution. UICC chrysotile (Ctl) and a non-fibrous antigorite (nf-Atg) were used as reference minerals. A high variability in toxicity was observed depending on shape, chemical alteration, and surface reactivity. The antigorites shared with Ctl a similar surface area (16.3, 12.1, 20.3, 13.4, and 15.6 m[2]/g for f-Atg1, 2, 3, nf-Atg, and Ctl). f-Atg showed different level of pedogenetic weathering (Ni depletion f-Atg1 ≪ f-Atg2 and 3) and contained about 50% of elongated mineral particles, some of which exhibited high aspect ratios (AR > 10 μm, 20%, 26%, 31% for f-Atg1, 2, and 3, respectively). The minerals differed in bio-accessible iron at pH 4.5 (f-Atg1 ≪ f-Atg3, < f-Atg2, nf-Atg < Ctl), and surface reactivity (ROS release in solution, f-Atg1 ≪ f-Atg2, 3, nf-Atg, and Ctl). f-Atg2 and f-Atg3 induced oxidative stress and pro-inflammatory responses, while the less altered, poorly reactive sample (f-Atg1) induced negligible effects, as well nf-Atg. The slow dissolution kinetics observed in simulated body fluids may signal a high biopersistence. Overall, our work revealed a significative cellular toxicity of f-Atg that correlates with fibrous habit and surface reactivity.},
}
@article {pmid36519024,
year = {2022},
author = {Klotz, LV and Hoffmann, H and Shah, R and Eichhorn, F and Gruenewald, C and Bulut, EL and Griffo, R and Muley, T and Christopoulos, P and Baum, P and Huber, P and Safi, S and Kriegsmann, M and Thomas, M and Bischoff, H and Winter, H and Eichhorn, ME},
title = {Multimodal therapy of epithelioid pleural mesothelioma: improved survival by changing the surgical treatment approach.},
journal = {Translational lung cancer research},
volume = {11},
number = {11},
pages = {2230-2242},
pmid = {36519024},
issn = {2218-6751},
abstract = {BACKGROUND: The exact role and type of surgery for malignant pleural mesothelioma (MPM) remains controversial. This study aimed at analyzing a 20-year single center perioperative experience in MPM surgery at our high-volume thoracic surgery center and comparing the overall survival after trimodal extrapleural pneumonectomy (EPP) and extended pleurectomy and decortication combined with hyperthermic intrathoracic chemoperfusion (EPD/HITOC) and adjuvant chemotherapy with that after chemotherapy (CTx) alone.<br><br>METHODS: Patients with epithelioid MPM treated with neoadjuvant chemotherapy, EPP and adjuvant radiotherapy within a trimodal concept or EPD/HITOC in combination with adjuvant chemotherapy between 2001 and 2018 were included in this retrospective analysis. Surgical cohorts were compared to patients treated with standard chemotherapy.<br><br>RESULTS: Overall, 182 patients (69 EPP, 57 EPD/HITOC, 56 CTx) were analyzed. Due to occupational exposure to asbestos for most of the patients, 154 patients (84.6%) were male. The patients in the surgical cohorts were significantly younger than those in the CTx cohort. There was no significant difference between the proportion of patient age and side. The median overall survival of the EPD/HITOC cohort with 38.1 months was significantly longer than that of the EPP and CTx cohorts (24.0 and 15.8 months). Better survival was significantly associated with an ECOG 0 performance status, age below 70 years, and negative lymph node status. In the multivariate analysis, EPD/HITOC was significantly associated with improved overall survival. Perioperative morbidity was lower in the EPD/HITOC group than in the EPP cohort.<br><br>CONCLUSIONS: EPD/HITOC is feasible and safe for localized epithelioid pleural mesothelioma. Changing the surgical approach to a less radical lung-sparing technique may improve overall survival compared to trimodal EPP.},
}
@article {pmid36506969,
year = {2022},
author = {Guglielmucci, F and Bonafede, M and Azzolina, D and Marinaccio, A and Franzoi, IG and Migliore, E and Mensi, C and Chellini, E and Romeo, E and Grosso, F and Granieri, A},
title = {Preliminary validation of a brief PROM assessing psychological distress in patients with malignant mesothelioma: The mesothelioma psychological distress tool-Patients.},
journal = {Frontiers in psychology},
volume = {13},
number = {},
pages = {974982},
pmid = {36506969},
issn = {1664-1078},
abstract = {OBJECTIVE: Psychological suffering in malignant mesothelioma (MM) differs from that in other cancers because of its occupational etiology, and we aimed to develop specific patient-reported outcome measures to assess it.<br><br>METHODS: We used a multi-method prospective observational multicentric study (N&#x2009;=&#x2009;149), and a preliminary questionnaire validation was performed through a Bayesian approach.<br><br>RESULTS: Item analysis showed a good internal consistency and reliability (Cronbach alpha&#x2009;=&#x2009;0.79 [95% CI&#x2009;=&#x2009;0.74-0.93]. Twenty of the 41 initial items were selected as posterior 95% highest density interval factor loading standardized effect size fell outside of the region of practical equivalence. Bayesian exploratory factor analysis showed a two-factor structure: (1) Trauma-related reactions (TR, 13 items) and (2) Claim for justice (CJ, 7 items), confirmed by the Bayesian confirmatory factor analysis. Latent factors were poorly correlated (Posterior median: 0.13; 95% CI&#x2009;=&#x2009;-0.079 to 0.323). The 90% root mean square error of approximation posterior median was 0.04 [90% CI&#x2009;=&#x2009;0.03-0.58]; the 90% chi-square posterior median was 242 [90% CI&#x2009;=&#x2009;209-287].<br><br>CONCLUSION: Psychological suffering in MM patients implies negative cognitive, emotional, and somatic reactions related to the traumatic impact of the disease and the need to obtain justice through economic compensation. Our findings provide preliminary evidence that the Mesothelioma Psychological Distress Tool-Patients could be a promising and reliable instrument to assess MM patients' psychological distress.},
}
@article {pmid36499762,
year = {2022},
author = {Munson, P and Shukla, A},
title = {Potential Roles of Exosomes in the Development and Detection of Malignant Mesothelioma: An Update.},
journal = {International journal of molecular sciences},
volume = {23},
number = {23},
pages = {},
pmid = {36499762},
issn = {1422-0067},
support = {R01 ES021110/ES/NIEHS NIH HHS/United States ; W81XWH-13-PRCRP-IA//Department of Defence/ ; ES021110/NH/NIH HHS/United States ; },
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/pathology ; *Lung Neoplasms/pathology ; *Asbestos/toxicity ; *Exosomes/pathology ; },
abstract = {Malignant mesothelioma (MM) is a devastating cancer of mesothelial cells, caused by asbestos exposure. Limited knowledge regarding the detection of asbestos exposure and the early diagnosis of MM, as well as a lack of successful treatment options for this deadly cancer, project an immediate need to understand the mechanism(s) of MM development. With the recent discovery of nano-vesicles, namely exosomes, and their enormous potential to contain signature molecules representative of different diseases, as well as to communicate with distant targets, we were encouraged to explore their role(s) in MM biology. In this review, we summarize what we know so far about exosomes and MM based on our own studies and on published literature from other groups in the field. We expect that the information contained in this review will help advance the field of MM forward by revealing the mechanisms of MM development and survival. Based on this knowledge, future therapeutic strategies for MM can potentially be developed. We also hope that the outcome of our studies presented here may help in the detection of MM.},
}
@article {pmid36498008,
year = {2022},
author = {Huh, DA and Chae, WR and Choi, YH and Kang, MS and Lee, YJ and Moon, KW},
title = {Disease Latency according to Asbestos Exposure Characteristics among Malignant Mesothelioma and Asbestos-Related Lung Cancer Cases in South Korea.},
journal = {International journal of environmental research and public health},
volume = {19},
number = {23},
pages = {},
pmid = {36498008},
issn = {1660-4601},
mesh = {Humans ; *Mesothelioma, Malignant ; *Asbestos/toxicity ; *Mesothelioma/epidemiology/etiology ; *Lung Neoplasms/chemically induced/epidemiology ; Republic of Korea/epidemiology ; *Occupational Exposure ; },
abstract = {Korea was one of the major consumers of asbestos in the late 1900s, and asbestos-related disease patients have been reported continuously to date, owing to long disease latency. Several studies have been conducted to predict the future incidence of malignant mesothelioma and lung cancer in Korea, but little is understood about the latency time. Therefore, the aim of this study is to estimate the latency period of malignant mesothelioma and asbestos-related lung cancer in Korea and its determinants. We obtained information from the Environmental Health Centers for Asbestos in Korea on the history of asbestos exposure and demographic characteristics of 1933 patients with malignant mesothelioma and asbestos-related lung cancer. In our study, the latency periods for malignant mesothelioma and lung cancer were 33.7 and 40.1 years, respectively. Regardless of the disease type, those with a history of exposure related to the production of asbestos-containing products or asbestos factories had the shortest latency period. In addition, we observed that those who worked in or lived near asbestos mines tended to have a relatively long disease latency. Smoking was associated with shorter latency, but no linear relationship between the lifetime smoking amount (expressed in pack years) and latent time was observed. In addition, the age of initial exposure showed a negative linear association with the latency period for mesothelioma and lung cancer.},
}
@article {pmid36475505,
year = {2022},
author = {Ferrari, L and Iodice, S and Cantone, L and Dallari, B and Dioni, L and Bordini, L and Palleschi, A and Mensi, C and Pesatori, AC},
title = {Identification of a new potential plasmatic biomarker panel for the diagnosis of malignant pleural mesothelioma.},
journal = {La Medicina del lavoro},
volume = {113},
number = {6},
pages = {e2022052},
pmid = {36475505},
issn = {0025-7818},
mesh = {Humans ; *Mesothelioma, Malignant ; *HMGB1 Protein ; Reproducibility of Results ; *MicroRNAs ; },
abstract = {BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare highly aggressive tumor strongly associated with asbestos exposure and characterized by poor prognosis. Currently, diagnosis is based on invasive techniques, thus there is a need of identifying non-invasive biomarkers for early detection of the disease among asbestos-exposed subjects. In the present study, we measured the plasmatic concentrations of Mesothelin, Fibulin-3, and HMGB1 protein biomarkers, and of hsa-miR-30e-3p and hsa-miR-103a-3p Extracellular-Vesicles- embedded micro RNAs (EV-miRNAs). We tested the ability of these biomarkers to discriminate between MPM and PAE subjects alone and in combination.<br><br>METHODS: the study was conducted on a population of 26 patients with MPM and 54 healthy subjects with previous asbestos exposure (PAE). Mesothelin, Fibulin-3, and HMGB1 protein biomarkers were measured by the enzyme-linked immunosorbent assay (ELISA) technique; the levels of hsa-miR-30e-3p and hsa-miR-103a-3p EV-miRNAs was assessed by quantitative real-time PCR (qPCR).<br><br>RESULTS: the most discriminating single biomarker resulted to be Fibulin-3 (AUC 0.94 CI 95% 0.88-1.0; Sensitivity 88%; Specificity 87%). After investigating the different possible combinations, the best performance was obtained by the three protein biomarkers Mesothelin, Fibulin-3, and HMGB1 (AUC 0.99 CI 95% 0.97-1.0; Sensitivity 96%; Specificity 93%).<br><br>CONCLUSIONS: the results obtained contribute to identifying new potential non-invasive biomarkers for the early diagnosis of MPM in high-risk asbestos-exposed subjects. Further studies are needed to validate the evidence obtained, in order to assess the reliability of the proposed biomarker panel.},
}
@article {pmid36466911,
year = {2022},
author = {Graham, PT and Nowak, AK and Cornwall, SMJ and Larma, I and Nelson, DJ},
title = {The STING agonist, DMXAA, reduces tumor vessels and enhances mesothelioma tumor antigen presentation yet blunts cytotoxic T cell function in a murine model.},
journal = {Frontiers in immunology},
volume = {13},
number = {},
pages = {969678},
pmid = {36466911},
issn = {1664-3224},
mesh = {Mice ; Animals ; T-Lymphocytes, Cytotoxic ; Antigen Presentation ; Disease Models, Animal ; *Mesothelioma, Malignant ; *Mesothelioma/drug therapy ; Ovalbumin ; Antigens, Neoplasm ; },
abstract = {We assessed the murine Stimulator of Interferon Genes (STING) agonist, DMXAA, for anti-mesothelioma potential using the AE17-sOVA model that expresses ovalbumin (OVA) as a neo tumor antigen. Dose response experiments alongside testing different routes of administration identified a safe effective treatment regimen that induced 100% cures in mice with small or large tumors. Three doses of 25mg/kg DMXAA given intra-tumorally every 9 days induced tumor regression and long-term survival (>5 months). Re-challenge experiments showed that tumor-free mice developed protective memory. MTT and propidium-iodide assays showed that DMXAA exerted direct cytotoxic effects at doses >1mg/ml on the murine AE17 and AB1 mesothelioma cell lines. In-vivo studies using a CFSE-based in-vivo proliferation assay showed that DMXAA improved tumor-antigen presentation in tumor-draining lymph nodes, evidenced by OVA-specific OT-1 T cells undergoing more divisions. An in-vivo cytotoxic T lymphocyte (CTL) assay showed that DMXAA blunted the lytic quality of CTLs recognizing the dominant (SIINFEKL) and a subdominant (KVVRFDKL) OVA epitopes. DMXAA reduced tumor vessel size in-vivo and although the proportion of T cells infiltrating tumors reduced, the proportion of tumor-specific T cells increased. These data show careful dosing and treatment protocols reduce mesothelioma cell viability and modulate tumor vessels such that tumor-antigen specific CTLs access the tumor site. However, attempts to enhance DMXAA-induced anti-tumor responses by combination with an agonist anti-CD40 antibody or IL-2 reduced efficacy. These proof-of-concept data suggest that mesothelioma patients could benefit from treatment with a STING agonist, but combination with immunotherapy should be cautiously undertaken.},
}
@article {pmid36465873,
year = {2022},
author = {Patel, JP and Brook, MS and Kah, M and Hamilton, A},
title = {Global geological occurrence and character of the carcinogenic zeolite mineral, erionite: A review.},
journal = {Frontiers in chemistry},
volume = {10},
number = {},
pages = {1066565},
pmid = {36465873},
issn = {2296-2646},
abstract = {As with the six regulated asbestos minerals (chrysotile, amosite, crocidolite, anthophyllite, tremolite, and actinolite), the zeolite mineral, erionite, can exhibit a fibrous morphology. When fibrous erionite is aerosolized and inhaled, it has been linked to cases of lung cancers, such as malignant mesothelioma. Importantly, fibrous erionite appears to be more carcinogenic than the six regulated asbestos minerals. The first health issues regarding erionite exposure were reported in Cappadocia (Turkey), and more recently, occupational exposure issues have emerged in the United States. Erionite is now classified as a Group 1 carcinogen. Thus, identifying the geological occurrence of erionite is a prudent step in determining possible exposure pathways, but a global review of the geological occurrence of erionite is currently lacking. Here, we provide a review of the >100 global locations where erionite has been reported, including: 1) geological setting of host rocks; 2) paragenetic sequence of erionite formation, including associated zeolite minerals; 3) fiber morphological properties and erionite mineral series (i.e., Ca, K, Na); and 4) a brief overview of the techniques that have been used to identify and characterize erionite. Accordingly, erionite has been found to commonly occur within two major rock types: felsic and mafic. Within felsic rocks (in particular, tuffaceous layers within lacustrine paleoenvironments), erionite is disseminated through the layer as a cementing matrix. In contrast, within mafic (i.e., basaltic) rocks, erionite is typically found within vesicles. Nevertheless, aside from detailed studies in Italy and the United States, there is a paucity of specific information on erionite geological provenance or fiber morphology. The latter issue is a significant drawback given its impact on erionite toxicity. Future erionite studies should aim to provide more detailed information, including variables such as rock type and lithological properties, quantitative geochemistry, and fiber morphology.},
}
@article {pmid36429481,
year = {2022},
author = {Handra, CM and Chirila, M and Smarandescu, RA and Ghita, I},
title = {Near Missed Case of Occupational Pleural Malignant Mesothelioma, a Case Report and Latest Therapeutic Options.},
journal = {International journal of environmental research and public health},
volume = {19},
number = {22},
pages = {},
pmid = {36429481},
issn = {1660-4601},
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/chemically induced/diagnosis/therapy ; *Pleural Neoplasms/diagnosis/therapy/complications ; *Asbestos/adverse effects ; *Occupational Exposure/adverse effects ; },
abstract = {Asbestos use started to be gradually banned in Europe from 1991 onwards, and there are currently strict occupational exposure limits for asbestos. However, malignant mesothelioma has a long latency time (in some cases up to 50-60 years), so the risks related to asbestos exposure should not be forgotten. Considering the increased risk of lung cancer following the inhalation of asbestos fibers, lifetime health monitoring should be considered in people occupationally exposed to asbestos, with an emphasis on the respiratory system. An assessment of their occupational history should be performed rigorously, especially in the areas with a history of asbestos production/use, as this is a key element for an early diagnosis and appropriate treatment. This case report presents a near-missed case of occupational pleural malignant mesothelioma. The latency time between the first asbestos exposure and the diagnosis of occupational pleural malignant mesothelioma was 49 years. The accurate diagnosis was made two years after the first symptoms appeared.},
}
@article {pmid36420194,
year = {2022},
author = {Keam, S and MacKinnon, KM and D'Alonzo, RA and Gill, S and Ebert, MA and Nowak, AK and Cook, AM},
title = {Effects of Photon Radiation on DNA Damage, Cell Proliferation, Cell Survival, and Apoptosis of Murine and Human Mesothelioma Cell Lines.},
journal = {Advances in radiation oncology},
volume = {7},
number = {6},
pages = {101013},
pmid = {36420194},
issn = {2452-1094},
abstract = {PURPOSE: To characterize the cellular responses of murine and human mesothelioma cell lines to different doses of photon radiation with a long-term aim of optimizing a clinically relevant in vivo model in which to study the interaction of radiation therapy and immunotherapy combinations.<br><br>METHODS AND MATERIALS: Two murine mesothelioma cell lines (AB1 and AE17) and 3 human cell lines (BYE, MC, and JU) were used in the study. Cells were treated with increasing doses of photon radiation. DNA damage, DNA repair, cell proliferation, and apoptosis at different time points after irradiation were quantified by flow cytometry, and cell survival probability was examined using clonogenic survival assay.<br><br>RESULTS: DNA damage increased with escalating dose in all cell lines. Evident G2/M arrest and reduced cell proliferation were observed after irradiation with 8 Gy. DNA repair was uniformly less efficient at higher compared with lower radiation-fraction doses. The apoptosis dose response varied between cell lines, with greater apoptosis observed at 16 Gy with human BYE and murine AB1 cell lines but less for other studied cell lines, regardless of dose and time. The &#x3b1;/&#x3b2; ratio from the cell survival fraction of human mesothelioma cell lines was smaller than from murine ones, suggesting human cell lines in our study were more sensitive to a change of dose per fraction than were murine mesothelioma cell lines. However, in all studied cell lines, colony formation was completely inhibited at 8 Gy.<br><br>CONCLUSIONS: A threshold dose of 8 Gy appeared to be appropriate for hypofractionated radiation therapy. However, the radiation therapy doses between 4 and 8 Gy remain to be systematically analyzed. These observations provide an accurate picture of the in vitro response of mesothelioma cell lines to photon irradiation and characterize the heterogeneity between human and murine cell lines. This information may guide in vivo experiments and the strengths and limitations of extrapolation from murine experimentation to potential human translation.},
}
@article {pmid36420072,
year = {2022},
author = {Yabuuchi, Y and Hiroshima, K and Oshima, H and Kanazawa, J and Hayashihara, K and Nakagawa, T and Shimanouchi, M and Usui, S and Oh-Ishi, S and Saito, T and Hizawa, N and Minami, Y},
title = {Usefulness of malignant pleural effusion for early cytological diagnosis of mesothelioma in situ: A case report.},
journal = {Oncology letters},
volume = {24},
number = {6},
pages = {440},
pmid = {36420072},
issn = {1792-1082},
abstract = {Mesothelioma in situ (MIS) is defined as a preinvasive mesothelioma that forms a single layer of mild atypical mesothelial cells lining on the serosa surface of pleura. The atypical mesothelial cells present loss of BRCA-1 associated protein-1 (BAP-1) and/or methylthioadenosine phosphorylase as examined by immunohistochemistry (IHC) and/or homozygous deletion of cyclin-dependent kinase inhibitor 2A/p16 as examined by fluorescence in situ hybridization. It is difficult to diagnose because of the unremarkable clinical findings except for pleural effusion. The present report describes a case in which MIS was diagnosed at the time of sampling due to the presence of clearly malignant mesothelial cells in the pleural fluid. In 2016, a 74-year-old man with a history of past exposure to asbestos was admitted to Ibaraki Higashi National Hospital (Tokai-mura, Japan) with dyspnea. Chest CT indicated only right pleural effusion. Malignant mesothelial cells were suspected in a cell block made using pleural effusion; therefore, right pleural biopsy was performed. Pathologically, there was proliferation of mesothelial cells with mild atypia that formed a single-flat layer on the pleural surface; however, there was no invasion. Furthermore, IHC revealed loss of BAP-1 in cells from the biopsied pleura and pleural effusion. MIS was suspected at the time; however, the patient arbitrarily quit his medical check-ups. After 44 months, the patient was readmitted to our hospital complaining of dyspnea. CT indicated a large right pleural mass. A specimen of the mass obtained via CT-guided needle biopsy revealed malignant mesothelioma. The patient continued to deteriorate and eventually died. This case indicated that pleural effusion could be used to demonstrate overtly malignant mesothelial cells and diagnose MIS at the time of sampling. To the best of our knowledge, this is first report of MIS with overtly malignant mesothelial cells in pleural effusion. Pleural effusion may serve an important role in MIS diagnosis.},
}
@article {pmid36410050,
year = {2022},
author = {Walter, M and Schenkeveld, WDC and Tomatis, M and Schelch, K and Peter-Vörösmarty, B and Geroldinger, G and Gille, L and Bruzzoniti, MC and Turci, F and Kraemer, SM and Grusch, M},
title = {The Potential Contribution of Hexavalent Chromium to the Carcinogenicity of Chrysotile Asbestos.},
journal = {Chemical research in toxicology},
volume = {35},
number = {12},
pages = {2335-2347},
pmid = {36410050},
issn = {1520-5010},
mesh = {Humans ; Asbestos, Serpentine/toxicity/chemistry ; Hydrogen Peroxide ; *Asbestos ; Chromium/toxicity ; Carcinogens/analysis ; *Lung Neoplasms/chemically induced ; },
abstract = {Chrysotile asbestos is a carcinogenic mineral that has abundantly been used in industrial and consumer applications. The carcinogenicity of the fibers is partly governed by reactive Fe surface sites that catalyze the generation of highly toxic hydroxyl radicals (HO[•]) from extracellular hydrogen peroxide (H2O2). Chrysotile also contains Cr, typically in the low mass permille range. In this study, we examined the leaching of Cr from fibers at the physiological lung pH of 7.4 in the presence and absence of H2O2. Furthermore, we investigated the potential of cells from typical asbestos-burdened tissues and cancers to take up Cr leached from chrysotile in PCR expression, immunoblot, and cellular Cr uptake experiments. Finally, the contribution of Cr to fiber-mediated H2O2 decomposition and HO[•] generation was studied. Chromium readily dissolved from chrysotile fibers in its genotoxic and carcinogenic hexavalent redox state upon oxidation by H2O2. Lung epithelial, mesothelial, lung carcinoma, and mesothelioma cells expressed membrane-bound Cr(VI) transporters and accumulated Cr up to 10-fold relative to the Cr(VI) concentration in the spiked medium. Conversely, anion transporter inhibitors decreased cellular Cr(VI) uptake up to 45-fold. Finally, chromium associated with chrysotile neither decomposed H2O2 nor contributed to fiber-mediated HO[•] generation. Altogether, our results support the hypothesis that Cr may leach from inhaled chrysotile in its hexavalent state and subsequently accumulate in cells of typically asbestos-burdened tissues, which could contribute to the carcinogenicity of chrysotile fibers. However, unlike Fe, Cr did not significantly contribute to the adverse radical production of chrysotile.},
}
@article {pmid36387076,
year = {2022},
author = {Chang, F and Keam, S and Hoang, TS and Creaney, J and Gill, S and Nowak, AK and Ebert, M and Cook, AM},
title = {Immune marker expression of irradiated mesothelioma cell lines.},
journal = {Frontiers in oncology},
volume = {12},
number = {},
pages = {1020493},
pmid = {36387076},
issn = {2234-943X},
abstract = {BACKGROUND: Though immune checkpoint inhibition has recently shown encouraging clinical efficacy in mesothelioma, most patients do not respond. Combining immune checkpoint inhibition with radiotherapy presents an attractive option for improving treatment responses owing to the various immunomodulatory effects of radiation on tumors. However, the ideal dosing and scheduling of combined treatment remains elusive, as it is poorly studied in mesothelioma. The present study characterizes the dose- and time-dependent changes to expression of various immune markers and cytokines important to antitumor responses following irradiation of mesothelioma cell lines.<br><br>METHODS: Two murine (AB1, AE17) and two human (BYE, JU77) mesothelioma cell lines were treated with titrated gamma-radiation doses (1-8 Gy) and the expression of MHC class-I, MHC class-II and PD-L1 was measured over a series of post-irradiation timepoints (1-72 hours) by flow cytometry. Levels of cytokines IL-1&#x3b1;, IL-1&#x3b2;, IL-6, IL-10, IL-12p70, IL-17A, IL-23, IL-27, MCP-1, IFN-&#x3b2;, IFN-&#x3b3;, TNF-&#x3b1;, and GM-CSF were measured by multiplex immunoassay in murine cell lines following 8 Gy radiation.<br><br>RESULTS: Following irradiation, a dose-dependent upregulation of MHC-I and PD-L1 was observed on three of the four cell lines studied to varying extents. For all cell lines, the increase in marker expression was most pronounced 72 hours after radiation. At this timepoint, increases in levels of cytokines IFN-&#x3b2;, MCP-1 and IL-6 were observed following irradiation with 8 Gy in AB1 but not AE17, reflecting patterns in marker expression.<br><br>CONCLUSIONS: Overall, this study establishes the dose- and time-dependent changes in immune marker expression of commonly studied mesothelioma cell lines following radiation and will inform future study into optimal dosing and scheduling of combined radiotherapy and immune checkpoint inhibition for mesothelioma.},
}
@article {pmid36362413,
year = {2022},
author = {Crovella, S and Moura, RR and Brandão, L and Vita, F and Schneider, M and Zanconati, F and Finotto, L and Zacchi, P and Zabucchi, G and Borelli, V},
title = {Variant Enrichment Analysis to Explore Pathways Disruption in a Necropsy Series of Asbestos-Exposed Shipyard Workers.},
journal = {International journal of molecular sciences},
volume = {23},
number = {21},
pages = {},
pmid = {36362413},
issn = {1422-0067},
support = {(Bando di Ricerca sanitaria 2017-programma 5 per mille anno 2015) and Municipality of Monfalcone (Gorizia)//Italian League for the Fight Against Cancer (LILT), ASSOCIAZIONE ISONTINA LILT/ ; decree 1124/SPS, 09/20/2016, N&#xb0; 1299//Regione Autonoma Friuli-Venezia Giulia, Assessorato alla Salute e Protezione Sociale, LR 22/2001/ ; BioHub 03/20//Institute for Maternal and Child Health IRCCS "Burlo Garofolo/Italian Ministry of Health"/ ; 311415/2020-2//Interreg Italia-Slovenia, ISE-EMH 07/2019; and by CNPq/ ; },
mesh = {Humans ; Autopsy ; *Asbestos/toxicity ; *Mesothelioma/chemically induced/genetics ; *Mesothelioma, Malignant ; *Lung Neoplasms/chemically induced/genetics ; *Occupational Exposure/adverse effects ; },
abstract = {The variant enrichment analysis (VEA), a recently developed bioinformatic workflow, has been shown to be a valuable tool for whole-exome sequencing data analysis, allowing finding differences between the number of genetic variants in a given pathway compared to a reference dataset. In a previous study, using VEA, we identified different pathway signatures associated with the development of pulmonary toxicities in mesothelioma patients treated with radical hemithoracic radiation therapy. Here, we used VEA to discover novel pathways altered in individuals exposed to asbestos who developed or not asbestos-related diseases (lung cancer or mesothelioma). A population-based autopsy study was designed in which asbestos exposure was evaluated and quantitated by investigating objective signs of exposure. We selected patients with similar exposure to asbestos. Formalin-fixed paraffin-embedded (FFPE) tissues were used as a source of DNA and whole-exome sequencing analysis was performed, running VEA to identify potentially disrupted pathways in individuals who developed thoracic cancers induced by asbestos exposure. By using VEA analysis, we confirmed the involvement of pathways considered as the main culprits for asbestos-induced carcinogenesis: oxidative stress and chromosome instability. Furthermore, we identified protective genetic assets preserving genome stability and susceptibility assets predisposing to a worst outcome.},
}
@article {pmid36362209,
year = {2022},
author = {Paajanen, J and Bueno, R and De Rienzo, A},
title = {The Rocky Road from Preclinical Findings to Successful Targeted Therapy in Pleural Mesothelioma.},
journal = {International journal of molecular sciences},
volume = {23},
number = {21},
pages = {},
pmid = {36362209},
issn = {1422-0067},
mesh = {Humans ; *Lung Neoplasms/drug therapy/genetics/chemically induced ; *Mesothelioma/drug therapy/genetics/chemically induced ; *Mesothelioma, Malignant ; *Pleural Neoplasms/drug therapy/genetics ; *Asbestos/adverse effects ; Ubiquitin Thiolesterase/genetics ; },
abstract = {Pleural mesothelioma (PM) is a rare and aggressive disease that arises from the mesothelial cells lining the pleural cavity. Approximately 80% of PM patients have a history of asbestos exposure. The long latency period of 20-40 years from the time of asbestos exposure to diagnosis, suggests that multiple somatic genetic alterations are required for the tumorigenesis of PM. The genomic landscape of PM has been characterized by inter- and intratumor heterogeneity associated with the impairment of tumor suppressor genes such as CDKN2A, NF2, and BAP1. Current systemic therapies have shown only limited efficacy, and none is approved for patients with relapsed PM. Advances in understanding of the molecular landscape of PM has facilitated several biomarker-driven clinical trials but so far, no predictive biomarkers for targeted therapies are in clinical use. Recent advances in the PM genetics have provided optimism for successful molecular strategies in the future. Here, we summarize the molecular mechanism underlying PM pathogenesis and review potential therapeutic targets.},
}
@article {pmid36361401,
year = {2022},
author = {Vorster, T and Mthombeni, J and teWaterNaude, J and Phillips, JI},
title = {The Association between the Histological Subtypes of Mesothelioma and Asbestos Exposure Characteristics.},
journal = {International journal of environmental research and public health},
volume = {19},
number = {21},
pages = {},
pmid = {36361401},
issn = {1660-4601},
mesh = {Humans ; Female ; *Mesothelioma, Malignant ; *Asbestos ; *Mesothelioma/epidemiology ; Asbestos, Crocidolite/toxicity ; Mining ; *Occupational Exposure ; *Occupational Diseases/epidemiology ; *Lung Neoplasms/pathology ; },
abstract = {Asbestos mining operations have left South Africa with a legacy of asbestos contamination and asbestos-related diseases continue to be a problem. The large-scale mining of three types of asbestos presents a unique opportunity to study malignant mesothelioma of the pleura (mesothelioma) in South Africa. This study aimed to describe the demographics of deceased individuals diagnosed with mesothelioma and explore any associations between the histological morphology of mesothelioma and asbestos characteristics. We reviewed the records of all deceased miners and ex-miners from the Pathology Automation System (PATHAUT) database of the National Institute of Occupational Health (NIOH) that were histologically diagnosed with mesothelioma in the period from January 2006-December 2016 (11 years). The study population does not include all cases of mesothelioma in South Africa but rather those that reached the compensation system. Crocidolite asbestos fibres were identified in the majority of mesothelioma cases (n = 140; 53.4%). The epithelioid subtype was most commonly present in both occupational and environmental cases. Cases with the sarcomatous subtype were older at death and fewer female cases were diagnosed with this subtype. No relationship between mesothelioma subtype and asbestos type or asbestos burden or fibre size was established.},
}
@article {pmid36357176,
year = {2023},
author = {Azzolina, D and Consonni, D and Ferrante, D and Mirabelli, D and Silvestri, S and Luberto, F and Angelini, A and Cuccaro, F and Nannavecchia, AM and Oddone, E and Vicentini, M and Barone-Adesi, F and Cena, T and Mangone, L and Roncaglia, F and Sala, O and Menegozzo, S and Pirastu, R and Tunesi, S and Chellini, E and Miligi, L and Perticaroli, P and Pettinari, A and Bressan, V and Merler, E and Girardi, P and Bisceglia, L and Marinaccio, A and Massari, S and Magnani, C and , },
title = {Rate advancement measurement for lung cancer and pleural mesothelioma in asbestos-exposed workers.},
journal = {Thorax},
volume = {78},
number = {8},
pages = {808-815},
doi = {10.1136/thorax-2021-217862},
pmid = {36357176},
issn = {1468-3296},
mesh = {Humans ; *Asbestos/toxicity ; Cohort Studies ; Italy/epidemiology ; *Lung Neoplasms/epidemiology/mortality ; *Mesothelioma/epidemiology/mortality ; Mortality/trends ; *Occupational Diseases/epidemiology/mortality ; *Occupational Exposure/adverse effects ; *Pleural Neoplasms/epidemiology/mortality ; Risk Assessment ; Male ; Female ; Construction Industry ; Adult ; Middle Aged ; Aged ; },
abstract = {INTRODUCTION: Exposure to asbestos increases the risk of lung cancer and mesothelioma. Few studies quantified the premature occurrence of these diseases in asbestos-exposed workers. Focus on premature disease onset (rate advancement or acceleration) can be useful in risk communication and for the evaluation of exposure impact. We estimated rate advancement for total mortality, lung cancer and pleural mesothelioma deaths, by classes of cumulative asbestos exposure in a pooled cohort of asbestos cement (AC) workers in Italy.<br><br>METHOD: The cohort study included 12&#x2009;578 workers from 21 cohorts, with 6626 deaths in total, 858 deaths from lung cancer and 394 from pleural malignant neoplasm (MN). Rate advancement was estimated by fitting a competitive mortality Weibull model to the hazard of death over time since first exposure (TSFE).<br><br>RESULT: Acceleration time (AT) was estimated at different TSFE values. The highest level of cumulative exposure compared with the lowest, for pleural MN AT was 16.9 (95% CI 14.9 to 19.2) and 33.8 (95% CI 29.8 to 38.4) years at TSFE of 20 and 40 years, respectively. For lung cancer, it was 13.3 (95% CI 12.0 to 14.7) and 26.6 (95% CI 23.9 to 29.4) years, respectively. As for total mortality, AT was 3.35 (95% CI 2.98 to 3.71) years at 20 years TSFE, and 6.70 (95% CI 5.95 to 7.41) at 40 years TSFE.<br><br>CONCLUSION: The current study observed marked rate advancement after asbestos exposure for lung cancer and pleural mesothelioma, as well as for total mortality.},
}
@article {pmid36355620,
year = {2022},
author = {Kadariya, Y and Sementino, E and Shrestha, U and Gorman, G and White, JM and Ross, EA and Clapper, ML and Neamati, N and Miller, MS and Testa, JR},
title = {Inflammation as a chemoprevention target in asbestos-induced malignant mesothelioma.},
journal = {Carcinogenesis},
volume = {43},
number = {12},
pages = {1137-1148},
pmid = {36355620},
issn = {1460-2180},
support = {P30 CA006927/CA/NCI NIH HHS/United States ; HHSN261201500032I/NH/NIH HHS/United States ; },
mesh = {Mice ; Animals ; *Mesothelioma, Malignant ; Interleukin-6/genetics ; Sulindac ; Interleukin 1 Receptor Antagonist Protein/adverse effects ; Cytokine Receptor gp130/metabolism ; *Asbestos/toxicity ; Carcinogenesis ; Inflammation/drug therapy/pathology ; Chemoprevention ; *Mesothelioma/chemically induced/prevention &amp; control/genetics ; },
abstract = {Malignant mesothelioma (MM) is an incurable cancer of the serosal lining that is often caused by exposure to asbestos. Therefore, novel agents for the prevention and treatment of this disease are urgently needed. Asbestos induces the release of pro-inflammatory cytokines such as IL-1β and IL-6, which play a role in MM development. IL-6 is a component of the JAK-STAT3 pathway that contributes to inflammation-associated tumorigenesis. Glycoprotein 130 (gp130), the signal transducer of this signaling axis, is an attractive drug target because of its role in promoting neoplasia via the activation of downstream STAT3 signaling. The anticancer drug, SC144, inhibits the interaction of gp130 with the IL-6 receptor (IL6R), effectively blunting signaling from this inflammatory axis. To test whether the inflammation-related release of IL-6 plays a role in the formation of MM, we evaluated the ability of SC144 to inhibit asbestos-induced carcinogenesis in a mouse model. The ability of sulindac and anakinra, an IL6R antagonist/positive control, to inhibit MM formation in this model was tested in parallel. Asbestos-exposed Nf2+/-;Cdkn2a+/- mice treated with SC144, sulindac or anakinra showed significantly prolonged survival compared to asbestos-exposed vehicle-treated mice. STAT3 activity was markedly decreased in MM specimens from SC144-treated mice. Furthermore, SC144 inhibited STAT3 activation by IL-6 in cultured normal mesothelial cells, and in vitro treatment of MM cells with SC144 markedly decreased the expression of STAT3 target genes. The emerging availability of newer, more potent SC144 analogs showing improved pharmacokinetic properties holds promise for future trials, benefitting individuals at high risk of this disease.},
}
@article {pmid36346299,
year = {2022},
author = {Fassio, F and Bussa, M and Oddone, E and Ferraro, OE and Puci, MV and Morandi, A and Castaldo, F and Broi, M and Uberti, F and Villani, S and Montomoli, C and Monti, MC},
title = {Health status of petrochemical workers: a narrative review.},
journal = {Giornale italiano di medicina del lavoro ed ergonomia},
volume = {44},
number = {1},
pages = {51-58},
pmid = {36346299},
issn = {1592-7830},
mesh = {Male ; Humans ; *Petroleum/toxicity ; *Mesothelioma ; *Occupational Exposure/adverse effects ; Health Status ; *Leukemia/complications ; *Occupational Diseases/epidemiology/etiology ; },
abstract = {Professional exposure to benzene has been extensively investigated by occupational medicine, leading to strict regulation of exposure threshold values. However, the petrochemical industry utilizes many chemical substances, whose exposure, without effective control and mitigation actions, could influence the health status over time. The aim of this narrative review is to describe health status of petrochemical workers related to occupational exposures, inquiring literature from 1980 to present. We used the PubMed and Web of Science search engines. As regards non-neoplastic diseases, despite heterogeneous prevalence estimates, we could say that standardized mortality rate (SMR) for hypertension, hypercholesterolemia and diabetes does not increase overall, compared to reference populations; a possible explanation may be the "healthy worker effect". Attention should be paid to color disperception and respiratory symptoms, due to toxic or irritating substances exposure. Studies concerning neoplastic pathology have mainly investigated mortality outcomes, finding no increase in cancer, except for melanoma or other skin cancers and leukemia. As regards the former, however, it is not excluded that other risk factors may contribute (e.g. UV rays in offshore workers), while for leukemia, only the most recent studies have analyzed various subtypes of hematopoietic tumors, highlighting a possible risk for the development of myelodysplastic syndrome. The risk of pleural mesothelioma was also increased, likely due to asbestos exposures, while the risk of death from prostate cancer remains controversial.},
}
@article {pmid36325490,
year = {2022},
author = {Ge, T and Phung, AL and Jhala, G and Trivedi, P and Principe, N and De George, DJ and Pappas, EG and Litwak, S and Sanz-Villanueva, L and Catterall, T and Fynch, S and Boon, L and Kay, TW and Chee, J and Krishnamurthy, B and Thomas, HE},
title = {Diabetes induced by checkpoint inhibition in nonobese diabetic mice can be prevented or reversed by a JAK1/JAK2 inhibitor.},
journal = {Clinical &amp; translational immunology},
volume = {11},
number = {11},
pages = {e1425},
pmid = {36325490},
issn = {2050-0068},
abstract = {OBJECTIVES: Immune checkpoint inhibitors have achieved clinical success in cancer treatment, but this treatment causes immune-related adverse events, including type 1 diabetes (T1D). Our aim was to test whether a JAK1/JAK2 inhibitor, effective at treating spontaneous autoimmune diabetes in nonobese diabetic (NOD) mice, can prevent diabetes secondary to PD-L1 blockade.<br><br>METHODS: Anti-PD-L1 antibody was injected into NOD mice to induce diabetes, and JAK1/JAK2 inhibitor LN3103801 was administered by oral gavage to prevent diabetes. Flow cytometry was used to study T cells and beta cells. Mesothelioma cells were inoculated into BALB/c mice to induce a transplantable tumour model.<br><br>RESULTS: Anti-PD-L1-induced diabetes was associated with increased immune cell infiltration in the islets and upregulated MHC class I on islet cells. Anti-PD-L1 administration significantly increased islet T cell proliferation and islet-specific CD8[+] T cell numbers in peripheral lymphoid organs. JAK1/JAK2 inhibitor treatment blocked IFN&#x3b3;-mediated MHC class I upregulation on beta cells and T cell proliferation mediated by cytokines that use the common &#x3b3; chain receptor. As a result, anti-PD-L1-induced diabetes was prevented by JAK1/JAK2 inhibitor administered before or after checkpoint inhibitor therapy. Diabetes was also reversed when the&#xa0;JAK1/JAK2 inhibitor was administered after the onset of anti-PD-L1-induced hyperglycaemia. Furthermore, JAK1/JAK2 inhibitor intervention after checkpoint inhibitors did not reverse or abrogate the antitumour effects in a transplantable tumour model.<br><br>CONCLUSION: A JAK1/JAK2 inhibitor can prevent and reverse anti-PD-L1-induced diabetes by blocking IFN&#x3b3; and &#x3b3;c cytokine activities. Our study provides preclinical validation of JAK1/JAK2 inhibitor use in checkpoint inhibitor-induced diabetes.},
}
@article {pmid36318367,
year = {2022},
author = {Caporali, S and Butera, A and Amelio, I},
title = {BAP1 in cancer: epigenetic stability and genome integrity.},
journal = {Discover oncology},
volume = {13},
number = {1},
pages = {117},
pmid = {36318367},
issn = {2730-6011},
abstract = {Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1 monoallelic mutations display hypersusceptibility to exposure-associated cancers, such as asbestos-driven mesothelioma, thus BAP1 status has been postulated to participate in gene-environment interaction. Intriguingly, BAP1 functions display also a high degree of tissue dependency, associated to a peculiar cancer spectrum and cell types of specific functions. Mechanistically, BAP1 functions as an ubiquitin carboxy-terminal hydrolase (UCH) and controls regulatory ubiquitination of histones as well as degradative ubiquitination of a range of protein substrates. In this article we provide an overview of the most relevant findings on BAP1, underpinning its tissue specific tumour suppressor function. We also discuss the importance of its epigenetic role versus the control of protein stability in the regulation of genomic integrity.},
}
@article {pmid36305648,
year = {2023},
author = {Allione, A and Viberti, C and Cotellessa, I and Catalano, C and Casalone, E and Cugliari, G and Russo, A and Guarrera, S and Mirabelli, D and Sacerdote, C and Gentile, M and Eichelmann, F and Schulze, MB and Harlid, S and Eriksen, AK and Tjønneland, A and Andersson, M and Dollé, MET and Van Puyvelde, H and Weiderpass, E and Rodriguez-Barranco, M and Agudo, A and Heath, AK and Chirlaque, MD and Truong, T and Dragic, D and Severi, G and Sieri, S and Sandanger, TM and Ardanaz, E and Vineis, P and Matullo, G},
title = {Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma: The EPIC prospective cohort.},
journal = {International journal of cancer},
volume = {152},
number = {4},
pages = {725-737},
doi = {10.1002/ijc.34339},
pmid = {36305648},
issn = {1097-0215},
support = {1000143/MRC_/Medical Research Council/United Kingdom ; C8221/A29017/CRUK_/Cancer Research UK/United Kingdom ; MR/N003284/1/MRC_/Medical Research Council/United Kingdom ; MR/M012190/1/MRC_/Medical Research Council/United Kingdom ; G0401527/MRC_/Medical Research Council/United Kingdom ; G1000143/MRC_/Medical Research Council/United Kingdom ; 14136/CRUK_/Cancer Research UK/United Kingdom ; MR/S019669/1/MRC_/Medical Research Council/United Kingdom ; 001/WHO_/World Health Organization/International ; },
mesh = {Humans ; Child, Preschool ; *Mesothelioma, Malignant ; *Mesothelioma/diagnosis/genetics/pathology ; DNA Methylation ; Case-Control Studies ; Prospective Studies ; *Pleural Neoplasms/diagnosis/genetics/pathology ; Biomarkers, Tumor/metabolism ; *Asbestos/adverse effects ; Genetic Markers ; Blood Cells ; *Lung Neoplasms/diagnosis/genetics/pathology ; },
abstract = {Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer mainly caused by asbestos exposure. Specific and sensitive noninvasive biomarkers may facilitate and enhance screening programs for the early detection of cancer. We investigated DNA methylation (DNAm) profiles in MPM prediagnostic blood samples in a case-control study nested in the European Prospective Investigation into Cancer and nutrition (EPIC) cohort, aiming to characterise DNAm biomarkers associated with MPM. From the EPIC cohort, we included samples from 135 participants who developed MPM during 20 years of follow-up and from 135 matched, cancer-free, controls. For the discovery phase we selected EPIC participants who developed MPM within 5 years from enrolment (n = 36) with matched controls. We identified nine differentially methylated CpGs, selected by 10-fold cross-validation and correlation analyses: cg25755428 (MRI1), cg20389709 (KLF11), cg23870316, cg13862711 (LHX6), cg06417478 (HOOK2), cg00667948, cg01879420 (AMD1), cg25317025 (RPL17) and cg06205333 (RAP1A). Receiver operating characteristic (ROC) analysis showed that the model including baseline characteristics (age, sex and PC1wbc) along with the nine MPM-related CpGs has a better predictive value for MPM occurrence than the baseline model alone, maintaining some performance also at more than 5 years before diagnosis (area under the curve [AUC] < 5 years = 0.89; AUC 5-10 years = 0.80; AUC >10 years = 0.75; baseline AUC range = 0.63-0.67). DNAm changes as noninvasive biomarkers in prediagnostic blood samples of MPM cases were investigated for the first time. Their application can improve the identification of asbestos-exposed individuals at higher MPM risk to possibly adopt more intensive monitoring for early disease identification.},
}
@article {pmid36304150,
year = {2022},
author = {Lam, SK and Yan, S and Lam, JS and Feng, Y and Khan, M and Chen, C and Ko, FC and Ho, JC},
title = {Disturbance of the Warburg effect by dichloroacetate and niclosamide suppresses the growth of different sub-types of malignant pleural mesothelioma in vitro and in vivo.},
journal = {Frontiers in pharmacology},
volume = {13},
number = {},
pages = {1020343},
pmid = {36304150},
issn = {1663-9812},
abstract = {Background: Inhalation of asbestos fibers is the most common cause of malignant pleural mesothelioma (MPM). In 2004, the United States Food and Drug Administration approved a combination of cisplatin with pemetrexed to treat unresectable MPM. Nonetheless novel treatment is urgently needed. The objective of this study is to report the combination effect of dichloroacetate (DCA) or niclosamide (Nic) Nic in MPM. Materials and methods: The effect of a combination of DCA and Nic was studied using a panel of MPM cell lines (H28, MSTO-211H, H226, H2052, and H2452). Cell viability was monitored by MTT assay. Glycolysis, oxidative phosphorylation, glucose, glycogen, pyruvate, lactate, citrate, succinate and ATP levels were determined by corresponding ELISA. Apoptosis, mitochondrial transmembrane potential, cell cycle analysis, hydrogen peroxide and superoxide were investigated by flow cytometry. Cell migration and colony formation were investigated by transwell migration and colony formation assays respectively. The in vivo effect was confirmed using 211H and H226 nude mice xenograft models. Results and conclusion: Cell viability was reduced. Disturbance of glycolysis and/or oxidative phosphorylation resulted in downregulation of glycogen, citrate and succinate. DCA and/or Nic increased apoptosis, mitochondrial transmembrane depolarization, G2/M arrest and reactive oxygen species. Moreover, DCA and/or Nic suppressed cell migration and colony formation. Furthermore, a better initial tumor suppressive effect was induced by the DCA/Nic combination compared with either drug alone in both 211H and H226 xenograft models. In H226 xenografts, DCA/Nic increased median survival of mice compared with single treatment. Single drug and/or a combination disturbed the Warburg effect and activated apoptosis, and inhibition of migration and proliferation in vivo. In conclusion, dichloroacetate and/or niclosamide showed a tumor suppressive effect in MPM in vitro and in vivo, partially mediated by disturbance of glycolysis/oxidative phosphorylation, apoptosis, ROS production, G2/M arrest, and suppression of migration and proliferation.},
}
@article {pmid36293328,
year = {2022},
author = {Chernova, T and Grosso, S and Sun, XM and Tenor, AR and Cabeza, JZ and Craxton, A and Self, EL and Nakas, A and Cain, K and MacFarlane, M and Willis, AE},
title = {Extracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells.},
journal = {International journal of molecular sciences},
volume = {23},
number = {20},
pages = {},
pmid = {36293328},
issn = {1422-0067},
support = {29372/CRUK_/Cancer Research UK/United Kingdom ; MC_UU_00025/4/MRC_/Medical Research Council/United Kingdom ; MC_UU_00025/5/MRC_/Medical Research Council/United Kingdom ; MC_UU_00025/5 (RG94521)/MRC_/Medical Research Council/United Kingdom ; MC_UU_00025/7/MRC_/Medical Research Council/United Kingdom ; },
mesh = {Humans ; *Mesothelioma, Malignant ; *Cancer-Associated Fibroblasts/metabolism ; YAP-Signaling Proteins ; Cell Line, Tumor ; *Mesothelioma/pathology ; *Extracellular Vesicles/metabolism ; Carcinogenesis/metabolism ; Simvastatin ; Tumor Microenvironment ; },
abstract = {Malignant mesothelioma is an aggressive tumour of the pleura (MPM) or peritoneum with a clinical presentation at an advanced stage of the disease. Current therapies only marginally improve survival and there is an urgent need to identify new treatments. Carcinoma-associated fibroblasts (CAFs) represent the main component of a vast stroma within MPM and play an important role in the tumour microenvironment. The influence of CAFs on cancer progression, aggressiveness and metastasis is well understood; however, the role of CAF-derived extracellular vesicles (CAF-EVs) in the promotion of tumour development and invasiveness is underexplored. We purified CAF-EVs from MPM-associated cells and healthy dermal human fibroblasts and examined their effect on cell proliferation and motility. The data show that exposure of healthy mesothelial cells to EVs derived from CAFs, but not from normal dermal human fibroblasts (NDHF) resulted in activating pro-oncogenic signalling pathways and increased proliferation and motility. Consistent with its role in suppressing Yes-Associated Protein (YAP) activation (which in MPM is a result of Hippo pathway inactivation), treatment with Simvastatin ameliorated the pro-oncogenic effects instigated by CAF-EVs by mechanisms involving both a reduction in EV number and changes in EV cargo. Collectively, these data determine the significance of CAF-derived EVs in mesothelioma development and progression and suggest new targets in cancer therapy.},
}
@article {pmid36282034,
year = {2022},
author = {Mangone, L and Storchi, C and Pinto, C and Giorgi Rossi, P and Bisceglia, I and Romanelli, A},
title = {Incidence of malignant mesothelioma and asbestos exposure in the Emilia-Romagna region, Italy.},
journal = {La Medicina del lavoro},
volume = {113},
number = {5},
pages = {e2022047},
pmid = {36282034},
issn = {0025-7818},
mesh = {Female ; Humans ; Male ; Middle Aged ; *Asbestos/adverse effects ; Incidence ; Italy/epidemiology ; *Mesothelioma/epidemiology/etiology ; *Mesothelioma, Malignant ; *Occupational Exposure/adverse effects ; *Pleural Neoplasms/epidemiology/etiology ; },
abstract = {BACKGROUND: The aim of this study is to describe the incidence of malignant mesothelioma (MM) and asbestos exposure in an Italian region in the period 1996-June 2021.<br><br>METHODS: The study included cases with microscopic confirmation and those with instrumental confirmation. For each case, information on sex, age, tumour site, morphology and date of diagnosis was collected, along with details of exposure to asbestos.<br><br>RESULTS: 3,097 cases of MM (2,233 males and 864 females) were registered: 90.8% with microscopic confirmation. A total of 2,840 cases involved the pleura (92%), 230 cases the peritoneum (7%), and a small number of cases the pericardium and testis (9 and 18, respectively). Most cases (78.0%) occurred after 65 years of age, while only 1.5% concerned individuals with age < 45 years. The standardized incidence rate for the entire period (adjusted to the 2000 Italian standard population and calculated per 100,000 person-years) was equal to 3.9 in males and 1.4 in females, and the trend showed an increase with age in both sexes. Concerning asbestos exposure, 79.7% of cases were exposed (86.7% males and 60.1% females). In 70.3%, exposure was occupational (83.4% males and 33.2% females), while 20.7% of females and 0.8% of males had familial exposure. Building construction, rolling stock manufacture/repair and metalworking were the most prevalent economic activities associated with occupational exposure.<br><br>CONCLUSIONS: This study offers an overview of MM in an Italian region characterized by high incidence and high exposure due to its particular production activities.},
}
@article {pmid36275913,
year = {2022},
author = {Quigley, N and Lang-Lazdunski, L and Boily-Daoust, C and Couture, C and Fortin, M},
title = {An unusual isolated anterior mediastinal lesion.},
journal = {Respirology case reports},
volume = {10},
number = {11},
pages = {e01059},
pmid = {36275913},
issn = {2051-3380},
abstract = {Malignant pleural mesothelioma (MPM) is an infrequent tumour of poor prognosis with a strong association with asbestos exposure. Pleural effusion or thickening is the most common radiological finding. Thoracoscopic biopsy is the diagnostic modality of choice. In our report, we present the case of a career welder who consulted with vocal cord palsy and an atypical anterior mediastinal lesion. An EBUS-TBNA-guided biopsy and a thorough cytological assessment led to an unexpected diagnosis of epithelioid MPM. A localized anterior mediastinal lesion is an extremely infrequent presentation of MPM that deserves clinical recognition.},
}
@article {pmid36240245,
year = {2022},
author = {Jiménez-Ramírez, C and Gilbert Weber, D and Aguilar-Madrid, G and Brik, A and Juárez-Pérez, CA and Casjens, S and Raiko, I and Brüning, T and Johnen, G and Cabello-López, A},
title = {Assessment of miR-103a-3p in leukocytes-No diagnostic benefit in combination with the blood-based biomarkers mesothelin and calretinin for malignant pleural mesothelioma diagnosis.},
journal = {PloS one},
volume = {17},
number = {10},
pages = {e0275936},
pmid = {36240245},
issn = {1932-6203},
mesh = {*Asbestos/adverse effects ; Bilirubin ; Biomarkers, Tumor/genetics ; Calbindin 2/genetics ; Creatinine ; Female ; GPI-Linked Proteins/genetics ; Glucose ; Humans ; Leukocytes/pathology ; *Lung Neoplasms/pathology ; Male ; Mesothelin ; *Mesothelioma/diagnosis/genetics ; *Mesothelioma, Malignant ; *MicroRNAs/genetics ; Middle Aged ; *Pleural Neoplasms/pathology ; },
abstract = {Malignant pleural mesothelioma (MPM) is a cancer associated with asbestos exposure and its diagnosis is challenging due to the moderate sensitivities of the available methods. In this regard, miR-103a-3p was considered to increase the sensitivity of established biomarkers to detect MPM. Its behavior and diagnostic value in the Mexican population has not been previously evaluated. In 108 confirmed MPM cases and 218 controls, almost all formerly exposed to asbestos, we quantified miR-103-3a-3p levels in leukocytes using quantitative Real-Time PCR, together with mesothelin and calretinin measured in plasma by ELISA. Sensitivity and specificity of miR-103-3a-3p alone and in combination with mesothelin and calretinin were determined. Bivariate analysis was performed using Mann-Whitney U test and Spearman correlation. Non-conditional logistic regression models were used to calculate the area under curve (AUC), sensitivity, and specificity for the combination of biomarkers. Mesothelin and calretinin levels were higher among cases, remaining as well among males and participants ≤60 years old (only mesothelin). Significant differences for miR-103a-3p were observed between male cases and controls, whereas significant differences between cases and controls for mesothelin and calretinin were observed in men and women. At 95.5% specificity the individual sensitivity of miR-103a-3p was 4.4% in men, whereas the sensitivity of mesothelin and calretinin was 72.2% and 80.9%, respectively. Positive correlations for miR-103a-3p were observed with age, environmental asbestos exposure, years with diabetes mellitus, and glucose levels, while negative correlations were observed with years of occupational asbestos exposure, creatinine, erythrocytes, direct bilirubin, and leukocytes. The addition of miR-103a-3p to mesothelin and calretinin did not increase the diagnostic performance for MPM diagnosis. However, miR-103a-3p levels were correlated with several characteristics in the Mexican population.},
}
@article {pmid36232554,
year = {2022},
author = {Gesmundo, I and Pedrolli, F and Vitale, N and Bertoldo, A and Orlando, G and Banfi, D and Granato, G and Kasarla, R and Balzola, F and Deaglio, S and Cai, R and Sha, W and Papotti, M and Ghigo, E and Schally, AV and Granata, R},
title = {Antagonist of Growth Hormone-Releasing Hormone Potentiates the Antitumor Effect of Pemetrexed and Cisplatin in Pleural Mesothelioma.},
journal = {International journal of molecular sciences},
volume = {23},
number = {19},
pages = {},
pmid = {36232554},
issn = {1422-0067},
support = {2017HRTZYA//Italian Ministry of Instruction and Research PRIN 2017/ ; 2017S55RXB_002//Italian Ministry of Instruction and Research PRIN 2017/ ; 2019-2022//Fondazione Buzzi Unicem/ ; },
mesh = {Cell Line, Tumor ; Cisplatin/pharmacology/therapeutic use ; Cyclin D1 ; Cyclooxygenase 2 ; Growth Hormone-Releasing Hormone ; *HMGB1 Protein ; Humans ; Insulin-Like Growth Factor I/therapeutic use ; Matrix Metalloproteinase 2 ; Matrix Metalloproteinase 9/genetics ; *Mesothelioma/drug therapy/pathology ; *Mesothelioma, Malignant ; NF-kappa B/metabolism ; Pemetrexed/pharmacology/therapeutic use ; *Pleural Neoplasms/drug therapy/pathology ; Vascular Endothelial Growth Factor A/metabolism ; },
abstract = {Pleural mesothelioma (PM) is an aggressive cancer with poor prognosis and no effective therapies, mainly caused by exposure to asbestos. Antagonists of growth hormone-releasing hormone (GHRH) display strong antitumor effects in many experimental cancers, including lung cancer and mesothelioma. Here, we aimed to determine whether GHRH antagonist MIA-690 potentiates the antitumor effect of cisplatin and pemetrexed in PM. In vitro, MIA-690, in combination with cisplatin and pemetrexed, synergistically reduced cell viability, restrained cell proliferation and enhanced apoptosis, compared with drugs alone. In vivo, the same combination resulted in a strong growth inhibition of MSTO-211H xenografts, decreased tumor cell proliferation and increased apoptosis. Mechanistically, MIA-690, particularly with chemotherapeutic drugs, inhibited proliferative and oncogenic pathways, such as MAPK ERK1/2 and cMyc, and downregulated cyclin D1 and B1 mRNAs. Inflammatory pathways such as NF-kB and STAT3 were also reduced, as well as oxidative, angiogenic and tumorigenic markers (iNOS, COX-2, MMP2, MMP9 and HMGB1) and growth factors (VEGF and IGF-1). Overall, these findings strongly suggest that GHRH antagonists of MIA class, such as MIA-690, could increase the efficacy of standard therapy in PM.},
}
@article {pmid36230710,
year = {2022},
author = {Johnson, B and Zhuang, L and Rath, EM and Yuen, ML and Cheng, NC and Shi, H and Kao, S and Reid, G and Cheng, YY},
title = {Exploring MicroRNA and Exosome Involvement in Malignant Pleural Mesothelioma Drug Response.},
journal = {Cancers},
volume = {14},
number = {19},
pages = {},
pmid = {36230710},
issn = {2072-6694},
support = {RSP-080-19/20//Tour de Cure/ ; },
abstract = {Malignant pleural mesothelioma (MPM) is a deadly thoracic malignancy and existing treatment options are limited. Chemotherapy remains the most widely used first-line treatment regimen for patients with unresectable MPM, but is hampered by drug resistance issues. The current study demonstrated a modest enhancement of MPM cell sensitivity to chemotherapy drug treatment following microRNA (miRNA) transfection in MPM cell lines, albeit not for all tested miRNAs. This effect was more pronounced for FAK (PND-1186) small molecule inhibitor treatment; consistent with previously published data. We previously established that MPM response to survivin (YM155) small molecule inhibitor treatment is unrelated to basal survivin expression. Here, we showed that MPM response to YM155 treatment is enhanced following miRNA transfection of YM155-resistant MPM cells. We determined that YM155-resistant MPM cells secrete a higher level of exosomes in comparison to YM155-sensitive MPM cells. Despite this, an exosome inhibitor (GW4896) did not enhance MPM cell sensitivity to YM155. Additionally, our study showed no evidence of a correlation between the mRNA expression of inhibitor of apoptosis (IAP) gene family members and MPM cell sensitivity to YM155. However, two drug transporter genes, ABCA6 and ABCA10, were upregulated in the MPM cell lines and correlated with poor sensitivity to YM155.},
}
@article {pmid36221913,
year = {2022},
author = {Hariharan, A and Qi, W and Rehrauer, H and Wu, L and Ronner, M and Wipplinger, M and Kresoja-Rakic, J and Sun, S and Oton-Gonzalez, L and Sculco, M and Serre-Beinier, V and Meiller, C and Blanquart, C and Fonteneau, JF and Vrugt, B and Rüschoff, JH and Opitz, I and Jean, D and de Perrot, M and Felley-Bosco, E},
title = {Heterogeneous RNA editing and influence of ADAR2 on mesothelioma chemoresistance and the tumor microenvironment.},
journal = {Molecular oncology},
volume = {16},
number = {22},
pages = {3949-3974},
pmid = {36221913},
issn = {1878-0261},
mesh = {Animals ; Mice ; RNA Editing/genetics ; Tumor Microenvironment/genetics ; Drug Resistance, Neoplasm/genetics ; RNA-Binding Proteins/genetics/metabolism ; Adenosine Deaminase/genetics/metabolism ; *Mesothelioma, Malignant ; *Mesothelioma/genetics ; },
abstract = {We previously observed increased levels of adenosine-deaminase-acting-on-dsRNA (Adar)-dependent RNA editing during mesothelioma development in mice exposed to asbestos. The aim of this study was to characterize and assess the role of ADAR-dependent RNA editing in mesothelioma. We found that tumors and mesothelioma primary cultures have higher ADAR-mediated RNA editing compared to mesothelial cells. Unsupervised clustering of editing in different genomic regions revealed heterogeneity between tumor samples as well as mesothelioma primary cultures. ADAR2 expression levels are higher in BRCA1-associated protein 1 wild-type tumors, with corresponding changes in RNA editing in transcripts and 3'UTR. ADAR2 knockdown and rescue models indicated a role in cell proliferation, altered cell cycle, increased sensitivity to antifolate treatment, and type-1 interferon signaling upregulation, leading to changes in the microenvironment in vivo. Our data indicate that RNA editing contributes to mesothelioma heterogeneity and highlights an important role of ADAR2 not only in growth regulation in mesothelioma but also in chemotherapy response, in addition to regulating inflammatory response downstream of sensing nucleic acid structures.},
}
@article {pmid36209608,
year = {2023},
author = {Gualtieri, AF},
title = {Journey to the centre of the lung. The perspective of a mineralogist on the carcinogenic effects of mineral fibres in the lungs.},
journal = {Journal of hazardous materials},
volume = {442},
number = {},
pages = {130077},
doi = {10.1016/j.jhazmat.2022.130077},
pmid = {36209608},
issn = {1873-3336},
mesh = {Humans ; Mineral Fibers/toxicity ; Asbestos, Crocidolite ; Asbestos, Serpentine ; *Zeolites/chemistry ; Asbestos, Amphibole/toxicity ; Lung ; *Lung Neoplasms/chemically induced ; *Asbestos/toxicity ; },
abstract = {This work reviews the bio-chemical mechanisms leading to adverse effects produced when mineral fibres are inhaled and transported in the lungs from the perspective of a mineralogist. The behaviour of three known carcinogenic mineral fibres (crocidolite, chrysotile, and fibrous-asbestiform erionite) during their journey through the upper respiratory tract, the deep respiratory tract and the pleural cavity is discussed. These three fibres have been selected as they are the most socially and economically relevant mineral fibres representative of the classes of chain silicates (amphiboles), layer silicates (serpentine), and framework silicates (zeolites), respectively. Comparison of the behaviour of these fibres is made according to their specific crystal-chemical assemblages and properties. Known biological and subsequent pathologic effects which lead and contribute to carcinogenesis are critically reviewed under the mineralogical perspective and in relation to recent progress in this multidisciplinary field of research. Special attention is given to the understanding of the cause-effect relationships for lung cancer and malignant mesothelioma. Comparison with interstitial pulmonary fibrosis, or "asbestosis", will also be made here. This overview highlights open issues, data gaps, and conflicts in the literature for these topics, especially as regards relative potencies of the three mineral fibres under consideration for lung cancer and mesothelioma. Finally, an attempt is made to identify future research lines suitable for a general comprehensive model of the carcinogenicity of mineral fibres.},
}
@article {pmid36187519,
year = {2022},
author = {Kazi, M and Vispute, T and Shah, P and Ramadwar, M and Bhandare, MS and Shrikhande, SV and Chaudhari, VA},
title = {Localized gastric mesothelioma with nodal metastasis-an exceptionally rare entity.},
journal = {Indian journal of surgical oncology},
volume = {13},
number = {3},
pages = {612-615},
pmid = {36187519},
issn = {0975-7651},
abstract = {Localized mesothelioma is a rare disease with very few reports of presentation in visceral organs. We report a case of localized gastric mesothelioma with lymph node metastasis in a 32-year-old man without asbestos exposure. A failed attempt at resection was made before presentation at another center. He was given perioperative chemotherapy that was followed by a D2 radical subtotal gastrectomy and hyperthermic intraperitoneal chemotherapy. Histopathology showed epithelioid mesothelioma with nodal metastasis but without visceral peritoneal involvement. Cytoreductive surgery and regional chemotherapy are standard in diffuse mesothelioma. Management of localized mesothelioma is anecdotal; however aggressive surgery plays a central role with selective use of perioperative chemotherapy.},
}
@article {pmid36181042,
year = {2022},
author = {Cimen, F and Agackiran, Y and Düzgün, S and Aloglu, M and Senturk, A and Atikcan, S},
title = {Factors affecting the life expectancy in malignant pleural mesothelioma: Our 10 years of studies and experience.},
journal = {Medicine},
volume = {101},
number = {39},
pages = {e30711},
pmid = {36181042},
issn = {1536-5964},
mesh = {Female ; Fluorodeoxyglucose F18 ; Humans ; Life Expectancy ; *Lung Neoplasms/pathology ; Male ; *Mesothelioma/diagnosis ; *Mesothelioma, Malignant ; *Pleural Diseases ; *Pleural Neoplasms/pathology ; Positron Emission Tomography Computed Tomography/methods ; Prognosis ; Radiopharmaceuticals ; Retrospective Studies ; Tomography, X-Ray Computed ; },
abstract = {Malignant pleural mesothelioma (MPM) is an aggressive tumor with a poor prognosis. In our study, we aimed to investigate the specific clinical, laboratory, and radiological features of the tumor and the prognostic effect of SUVmax (maximum standardized uptake values) according to PET/CT (positron emission tomography). Demographic, therapeutic, clinical, and survival information of patients diagnosed with histologically-validated pleural mesothelioma in our hospital between January 2010 to December 2019 will be retrospectively scanned from the hospital records. A total of 116 patients, 61 men (52.6%), and 55 women (47.4%), were analyzed. Thirty five patients (30.2%) were over the age of 65. Percentage of patients over 65 years of age, neutrophil count, and PET SUV Max values, asbestos exposure and pleural thickening rate were significantly higher in the deceased patients' group than in the living patients' group (P = .042, P = .039, P = .002, P = .004, P = .037). T stage (tumor stage), N stage (lymph nodes stage), metastasis stage, and Grade distribution were significantly higher in the deceased patients' group than in the living patients' group (P < .000, P < .000, P = .003, P < .000). The rates of chemotherapy and surgical treatment, right lung location, and epithelioid pathology were significantly lower in the deceased patients' group compared to the living patients' group (P = .016, P = .030, P = .018, P = .008). The mean follow-up time was 13 months. Key determinants of survival in MPM include age, male gender, neutrophil increase, pleural thickening, high PET SUV max values, stage, histological type, asbestos exposure, and treatment regimen.},
}
@article {pmid36174024,
year = {2022},
author = {Wang, X and Katz, S and Miura, J and Karakousis, G and Roshkovan, L and Walker, S and McNulty, S and Ciunci, C and Cengel, K and Langer, CJ and Marmarelis, ME},
title = {A single-center retrospective cohort study of perioperative systemic chemotherapy in diffuse malignant peritoneal mesothelioma.},
journal = {PloS one},
volume = {17},
number = {9},
pages = {e0275187},
pmid = {36174024},
issn = {1932-6203},
mesh = {Adjuvants, Immunologic ; Adjuvants, Pharmaceutic ; Humans ; *Mesothelioma, Malignant ; Middle Aged ; *Peritoneal Neoplasms/drug therapy/surgery ; Peritoneum ; Platinum ; Retrospective Studies ; },
abstract = {BACKGROUND: Diffuse malignant peritoneal mesothelioma (DMPM) is a rare variant of malignant mesothelioma, representing 10-15% of malignant mesothelioma cases. The preferred therapeutic approach is cytoreductive surgery (CRS) accompanied by hyperthermic intraperitoneal chemotherapy (HIPEC); the role of systemic chemotherapy is not well established. While some limited retrospective studies report worse outcomes with neoadjuvant chemotherapy, our institution has favored the use of neoadjuvant chemotherapy for symptom relief and surgical optimization. The aim of our study was to assess the outcomes of patients receiving neoadjuvant chemotherapy, compared to those receiving adjuvant or no perioperative chemotherapy.<br><br>PATIENTS AND METHODS: We conducted a single-center retrospective cohort study of treatment-na&#xef;ve, non-papillary DMPM patients seen at our institution between 1/1/2009 and 9/1/2019. We explored the effect of type of systemic therapy on clinical outcomes and estimated median overall survival (mOS) using Kaplan-Meier curves. Hazard ratios (HR) calculated by Cox proportional hazard model were used to estimate effect of the exposures on overall survival.<br><br>RESULTS: 47 patients were identified with DMPM (median age at diagnosis 61.2 years, 76.6% epithelioid histology, 74.5% white race, 55.3% known asbestos exposure). CRS was performed in 53.2% of patients (25/47); 76.0% of surgical patients received HIPEC (19/25). The majority received systemic chemotherapy (37/47, 78.7%); among patients receiving both CRS and chemotherapy, neoadjuvant chemotherapy was more common than adjuvant chemotherapy (12 neoadjuvant, 8 adjuvant). Overall mOS was 84.1 months. Among neoadjuvant patients, 10/12 underwent surgery, and 2 were lost to follow-up; the majority (9/10) had clinically stable or improved disease during the pre-operative period. There were numerical more issues with chemotherapy with the adjuvant patients (4/8: 2 switches in platinum agent, 2 patients stopped therapy) than with the neoadjuvant patients (2/10: 1 switch in platinum agent, 1 delay due to peri-procedural symptoms). Neoadjuvant chemotherapy was not associated with worse mOS compared to adjuvant chemotherapy (mOS NR vs 95.1 mo, HR 0.89, 95% CI 0.18-4.5, p = 0.89).<br><br>CONCLUSIONS: When used preferentially, the use of neoadjuvant chemotherapy in DMPM patients was not associated with worse outcomes compared to adjuvant chemotherapy. It was well-tolerated and did not prevent surgical intervention.},
}
@article {pmid36165817,
year = {2022},
author = {Han, Y and Zhang, T and Chen, H and Yang, X},
title = {Global magnitude and temporal trend of mesothelioma burden along with the contribution of occupational asbestos exposure in 204 countries and territories from 1990 to 2019: Results from the Global Burden of Disease Study 2019.},
journal = {Critical reviews in oncology/hematology},
volume = {179},
number = {},
pages = {103821},
doi = {10.1016/j.critrevonc.2022.103821},
pmid = {36165817},
issn = {1879-0461},
mesh = {Adult ; Aged ; Aged, 80 and over ; *Asbestos/adverse effects ; Global Burden of Disease ; Global Health ; Humans ; *Mesothelioma/epidemiology/etiology ; *Mesothelioma, Malignant ; Quality-Adjusted Life Years ; Risk Factors ; },
abstract = {Understanding the burden of mesothelioma with the contribution of occupational asbestos exposure globally provides essential foundations for cancer control, policy decisions and resource allocation. Globally, 34,511 incident cases, 29,251 deaths and 668,104 disability-adjusted life years (DALYs) of mesothelioma were estimated in 2019. The age-standardized rates of incidence, mortality and DALYs all showed a slightly declining trend over the past 30 years, but the latest absolute number of mesothelioma burden almost doubled since 1990. The burden rate decreased among the population aged under 70 years, but increased among the population aged over 80 years, especially in the High socio-demographic index (SDI) region. The burden rate of mesothelioma attributable to asbestos exposure was positively associated with SDI at the national level. This study depicted a continuous increase in mesothelioma burden globally over the past 30 years. Controlling occupational asbestos exposure will reduce the mesothelioma burden, especially for higher SDI regions.},
}
@article {pmid36161345,
year = {2022},
author = {Golka, K and Böthig, R and Weistenhöfer, W and Jungmann, OP and Bergmann, S and Zellner, M and Schöps, W},
title = {[Occupation-related cancer in urology-Current knowledge including environmental medical aspects].},
journal = {Urologie (Heidelberg, Germany)},
volume = {61},
number = {11},
pages = {1198-1207},
pmid = {36161345},
issn = {2731-7072},
mesh = {Male ; Humans ; Female ; *Trichloroethylene ; *Urology ; *Mesothelioma/etiology ; Occupations ; *Kidney Neoplasms/chemically induced ; },
abstract = {Occupation-related cancers are of considerable importance, which is not yet adequately recognized in the field of urology. The three numerically most significant entities are tumors of the urinary tract caused by carcinogenic aromatic amines or polycyclic aromatic hydrocarbons, renal cell cancer after high exposure to the solvent trichloroethylene, and mesotheliomas of the tunica vaginalis of the testis after exposure to asbestos; however, these can only be recognized as occupation-related if an occupational history regarding the hazard relevant to the organ bearing the tumor is documented from the beginning of employment, e.g. by a questionnaire. This is because the relevant exposures generally date back several decades. With the exception of high exposure to trichloroethylene, the substances mentioned can also environmentally trigger the same tumors. In the context of environmental risk factors, it is of considerable importance that smoking is now considered to be a trigger for some 50% of all bladder cancers in men and women; however, smoking cessation results in a reduction in smoking-related cancer risk of over 30% after only 3-4 years. Work and commuting accidents, which are considered occupational risks, can lead to urological sequelae. For example, increased tumors of the bladder can occur after spinal cord injury lasting longer than 10 years.},
}
@article {pmid36156859,
year = {2022},
author = {Algranti, E and Santana, VS and Campos, F and Salvi, L and Saito, CA and Cavalcante, F and Correa-Filho, HR},
title = {Analysis of Mortality from Asbestos-Related Diseases in Brazil Using Multiple Health Information Systems, 1996-2017.},
journal = {Safety and health at work},
volume = {13},
number = {3},
pages = {302-307},
pmid = {36156859},
issn = {2093-7911},
abstract = {BACKGROUND: In Brazil, asbestos was intensively used from the 1960s until its ban in 2017. Mesothelioma, asbestosis, and pleural plaques are typical asbestos-related diseases (ARD-T). To create an ARD-T national database, death records from 1996-2017 were retrieved from several health information systems (HIS).<br><br>METHODS: All national HIS containing coded diagnoses (ICD-10) and death information were obtained. Linkage was performed to create a single database of ARD-T death records, either as underlying or contributory causes, in adults aged 30 years and older.<br><br>RESULTS: A total of 3,057 ARD-T death records were found, 2,405 (76.4%) of which being malignant mesotheliomas (MM). Pleural MM (n&#xa0;=&#xa0;1,006; 41.8%) and unspecified MM (n&#xa0;=&#xa0;792; 32.9%) prevailed. Male to female MM ratio (M:F) was 1.4:1, and higher ratios were found for non-malignant ARD-T: 3.5:1 for asbestosis and 2.4:1 for pleural plaques. Male crude annual mesothelioma mortality (CMmm x1,000,000) was 0.98 in 1996 and 2.26 in 2017, a 131.1% increment, while for females it was 1.04 and 1.25, a 20.2% increase, correspondingly. The small number of deaths with asbestosis and pleural plaques records precluded conclusive interpretations.<br><br>CONCLUSIONS: Even with the linkage of several HIS, ARD-T in death records remained in low numbers. MM mortality in men was higher and showed a rapid increase and, along with non-malignant ARD-T, higher M:F ratios suggested a predominant pattern of work-related exposure. The monitoring of workplace and environmental asbestos exposure needs to be improved, as well as the workers surveillance, following the recent Brazilian ban.},
}
@article {pmid36139575,
year = {2022},
author = {Tedesco, J and Jaradeh, M and Vigneswaran, WT},
title = {Malignant Pleural Mesothelioma: Current Understanding of the Immune Microenvironment and Treatments of a Rare Disease.},
journal = {Cancers},
volume = {14},
number = {18},
pages = {},
pmid = {36139575},
issn = {2072-6694},
abstract = {Malignant pleural mesothelioma is a rare disease with an annual incidence of around 3000 cases a year in the United States. Most cases are caused by asbestos exposure, with a latency period of up to 40 years. Pleural mesothelioma is an aggressive disease process with overall survival of roughly 6-12 months after the time of diagnosis. It is divided into three subtypes: epithelioid, mixed type, and sarcomatoid type, with the epithelioid subtype having the best overall survival. Often, the treatment is multimodality with surgery, chemotherapy, and radiation. The survival benefit is improved but remains marginal. New treatment options involving targeted immune therapies appear to offer some promise. The tumor microenvironment is the ecosystem within the tumor that interacts and influences the host immune system. Understanding this complex interaction and how the host immune system is involved in the progression of the disease process is important to define and guide potential treatment options for this devastating and rare disease.},
}
@article {pmid36109807,
year = {2022},
author = {Hoang, NTD and Hassan, G and Suehiro, T and Mine, Y and Matsuki, T and Fujii, M},
title = {BMP and activin membrane-bound inhibitor regulate connective tissue growth factor controlling mesothelioma cell proliferation.},
journal = {BMC cancer},
volume = {22},
number = {1},
pages = {984},
pmid = {36109807},
issn = {1471-2407},
support = {16K15922//Japan Society for the Promotion of Science/ ; },
mesh = {Activins ; Animals ; Cell Proliferation/genetics ; *Connective Tissue Growth Factor/genetics ; Cyclin D3 ; Cyclin-Dependent Kinases ; Humans ; *Membrane Proteins/genetics ; *Mesothelioma, Malignant ; Mice ; },
abstract = {BACKGROUND: Malignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid progression and resistance to standard therapeutic modalities such as surgery, chemotherapy, and radiotherapy. Our previous studies have suggested that tumor cell-derived connective tissue growth factor (CTGF) regulates the proliferation of MM cells as well as the tumor growth in mouse xenograft models.<br><br>METHODS: In this study, we knock downed the bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) and CTGF in MM cells and investigated the relationship between both and their impact on the cell cycle and cell proliferation.<br><br>RESULTS: The knockdown of CTGF or BAMBI reduced MM cell proliferation. In contrast to CTGF knockdown which decreased BAMBI, knockdown of BAMBI increased CTGF levels. Knockdown of either BAMBI or CTGF reduced expression of the cell cycle regulators; cyclin D3, cyclin-dependent kinase (CDK)2, and CDK4. Further, in silico analysis revealed that higher BAMBI expression was associated with shorter overall survival rates among MM patients.<br><br>CONCLUSIONS: Our findings suggest that BAMBI is regulated by CTGF promoting mesothelioma growth by driving cell cycle progression. Therefore, the crosstalk between BAMBI and CTGF may be an effective therapeutic target for MM treatment.},
}
@article {pmid36091141,
year = {2022},
author = {Shi, H and Rath, EM and Lin, RCY and Sarun, KH and Clarke, CJ and McCaughan, BC and Ke, H and Linton, A and Lee, K and Klebe, S and Maitz, J and Song, K and Wang, Y and Kao, S and Cheng, YY},
title = {3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumor microenvironment for drug response studies.},
journal = {Frontiers in oncology},
volume = {12},
number = {},
pages = {973576},
pmid = {36091141},
issn = {2234-943X},
abstract = {Traditional studies using cancer cell lines are often performed on a two-dimensional (2D) cell culture model with a low success rate of translating to Phase I or Phase II clinical studies. In comparison, with the advent of developments three-dimensional (3D) cell culture has been championed as the latest cellular model system that better mimics in vivo conditions and pathological conditions such as cancer. In comparison to biospecimens taken from in vivo tissue, the details of gene expression of 3D culture models are largely undefined, especially in mesothelioma - an aggressive cancer with very limited effective treatment options. In this study, we examined the veracity of the 3D mesothelioma cell culture model to study cell-to-cell interaction, gene expression and drug response from 3D cell culture, and compared them to 2D cell and tumor samples. We confirmed via SEM analysis that 3D cells grown using the spheroid methods expressed highly interconnected cell-to-cell junctions. The 3D spheroids were revealed to be an improved mini-tumor model as indicated by the TEM visualization of cell junctions and microvilli, features not seen in the 2D models. Growing 3D cell models using decellularized lung scaffold provided a platform for cell growth and infiltration for all cell types including primary cell lines. The most time-effective method was growing cells in spheroids using low-adhesive U-bottom plates. However, not every cell type grew into a 3D model using the the other methods of hanging drop or poly-HEMA. Cells grown in 3D showed more resistance to chemotherapeutic drugs, exhibiting reduced apoptosis. 3D cells stained with H&amp;E showed cell-to-cell interactions and internal architecture that better represent that of in vivo patient tumors when compared to 2D cells. IHC staining revealed increased protein expression in 3D spheroids compared to 2D culture. Lastly, cells grown in 3D showed very different microRNA expression when compared to that of 2D counterparts. In conclusion, 3D cell models, regardless of which method is used. Showed a more realistic tumor microenvironment for architecture, gene expression and drug response, when compared to 2D cell models, and thus are superior preclinical cancer models.},
}
@article {pmid36077838,
year = {2022},
author = {Trassl, L and Stathopoulos, GT},
title = {KRAS Pathway Alterations in Malignant Pleural Mesothelioma: An Underestimated Player.},
journal = {Cancers},
volume = {14},
number = {17},
pages = {},
pmid = {36077838},
issn = {2072-6694},
support = {Translational Research Project to GTS and LT//German Center for Lung Research/ ; },
abstract = {Malignant pleural mesothelioma (MPM) is a rare, incurable cancer of the mesothelial cells lining the lungs and the chest wall that is mainly caused by asbestos inhalation. The molecular mechanisms of mesothelial carcinogenesis are still unclear despite comprehensive studies of the mutational landscape of MPM, and the most frequently mutated genes BAP1, NF2, CDKN2A, TP53, and TSC1 cannot cause MPM in mice in a standalone fashion. Although KRAS pathway alterations were sporadically detected in older studies employing targeted sequencing, they have been largely undetected by next generation sequencing. We recently identified KRAS mutations and copy number alterations in a significant proportion of MPM patients. Here, we review and analyze multiple human datasets and the published literature to show that, in addition to KRAS, multiple other genes of the KRAS pathway are perturbed in a significant proportion of patients with MPM.},
}
@article {pmid36077664,
year = {2022},
author = {Ranzato, E and Bonsignore, G and Martinotti, S},
title = {ER Stress Response and Induction of Apoptosis in Malignant Pleural Mesothelioma: The Achilles Heel Targeted by the Anticancer Ruthenium Drug BOLD-100.},
journal = {Cancers},
volume = {14},
number = {17},
pages = {},
pmid = {36077664},
issn = {2072-6694},
abstract = {Malignant mesothelioma is a rare cancer arising from the serosal surfaces of the body, mainly from the pleural layer. This cancer is strongly related to asbestos exposure and shows a very inauspicious prognosis, because there are scarce therapeutic options for this rare disease. Thus, there is an urgent need to develop novel therapeutic approaches to treat this form of cancer. To explore the biology of malignant pleural mesothelioma (MPM), we previously observed that MPM cell lines show high expression of the GRP78 protein, which is a chaperone protein and the master regulator of the unfolded protein response (UPR) that resides in the endoplasmic reticulum (ER). Based on our previous studies showing the importance of GRP78 in MPM, we observed that BOLD-100, a specific modulator of GRP78 and the UPR, shows cytotoxicity against MPM cells. Our studies demonstrated that BOLD-100 increases ROS production and Ca[2+] release from the ER, leading to ER stress activation and, ultimately, to cell death. Our in vitro data strongly suggest that BOLD-100 inhibits the growth of MPM cell lines, proposing the application as a single agent, or in combination with other standard-of-care drugs, to treat MPM.},
}
@article {pmid36077483,
year = {2022},
author = {Pietrofesa, RA and Chatterjee, S and Kadariya, Y and Testa, JR and Albelda, SM and Christofidou-Solomidou, M},
title = {Synthetic Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells.},
journal = {International journal of molecular sciences},
volume = {23},
number = {17},
pages = {},
pmid = {36077483},
issn = {1422-0067},
support = {1P30 ES013508-02/NH/NIH HHS/United States ; Office of the Vice Provost for Research//University of Pennsylvania School of Medicine/ ; NIH-R03 CA180548/NH/NIH HHS/United States ; 3P42ES023720-04S2/NH/NIH HHS/United States ; P30 ES013508/ES/NIEHS NIH HHS/United States ; },
mesh = {*Asbestos/toxicity ; Butylene Glycols ; Cytokines ; DNA Damage ; Glucosides ; *HMGB1 Protein ; Humans ; Inflammasomes ; Inflammation/pathology/prevention &amp; control ; Interleukin-18 ; Interleukin-6 ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha ; },
abstract = {Although alveolar macrophages play a critical role in malignant transformation of mesothelial cells following asbestos exposure, inflammatory and oxidative processes continue to occur in the mesothelial cells lining the pleura that may contribute to the carcinogenic process. Malignant transformation of mesothelial cells following asbestos exposure occurs over several decades; however, amelioration of DNA damage, inflammation, and cell injury may impede the carcinogenic process. We have shown in an in vitro model of asbestos-induced macrophage activation that synthetic secoisolariciresinol diglucoside (LGM2605), given preventively, reduced inflammatory cascades and oxidative/nitrosative cell damage. Therefore, it was hypothesized that LGM2605 could also be effective in reducing asbestos-induced activation and the damage of pleural mesothelial cells. LGM2605 treatment (50 µM) of huma n pleural mesothelial cells was initiated 4 h prior to exposure to asbestos (crocidolite, 20 µg/cm2). Supernatant and cells were evaluated at 0, 2, 4, and 8 h post asbestos exposure for reactive oxygen species (ROS) generation, DNA damage (oxidized guanine), inflammasome activation (caspase-1 activity) and associated pro-inflammatory cytokine release (IL-1β, IL-18, IL-6, TNFα, and HMGB1), and markers of oxidative stress (malondialdehyde (MDA) and 8-iso-prostaglandin F2a (8-iso-PGF2α). Asbestos induced a time-dependent ROS increase that was significantly (p < 0.0001) reduced (29.4%) by LGM2605 treatment. LGM2605 pretreatment also reduced levels of asbestos-induced DNA damage by 73.6% ± 1.0%. Although levels of inflammasome-activated cytokines, IL-1β and IL-18, reached 29.2 pg/mL ± 0.7 pg/mL and 43.9 pg/mL ± 0.8 pg/mL, respectively, LGM2605 treatment significantly (p < 0.0001) reduced cytokine levels comparable to baseline (non-asbestos exposed) values (3.8 pg/mL ± 0.2 pg/mL and 5.4 pg/mL ± 0.2 pg/mL, respectively). Furthermore, levels of IL-6 and TNFα in asbestos-exposed mesothelial cells were high (289.1 pg/mL ± 2.9 pg/mL and 511.3 pg/mL ± 10.2 pg/mL, respectively), while remaining undetectable with LGM2605 pretreatment. HMGB1 (a key inflammatory mediator and initiator of malignant transformation) release was reduced 75.3% ± 0.4% by LGM2605. Levels of MDA and 8-iso-PGF2α, markers of oxidative cell injury, were significantly (p < 0.001) reduced by 80.5% ± 0.1% and 76.6% ± 0.3%, respectively. LGM2605, given preventively, reduced ROS generation, DNA damage, and inflammasome-activated cytokine release and key inflammatory mediators implicated in asbestos-induced malignant transformation of normal mesothelial cells.},
}
@article {pmid36054746,
year = {2022},
author = {Mai, HL and Deshayes, S and Nguyen, TV and Dehame, V and Chéné, AL and Brouard, S and Blanquart, C},
title = {IL-7 is expressed in malignant mesothelioma and has a prognostic value.},
journal = {Molecular oncology},
volume = {16},
number = {20},
pages = {3606-3619},
pmid = {36054746},
issn = {1878-0261},
mesh = {Humans ; *Mesothelioma, Malignant ; *Mesothelioma/genetics/diagnosis ; *Pleural Neoplasms/genetics ; Interleukin-7 ; Prognosis ; *Asbestos ; *Lung Neoplasms/pathology ; Receptors, Interleukin-7 ; Biomarkers ; },
abstract = {Malignant pleural mesothelioma (MPM) is an aggressive cancer mainly related to asbestos exposure. Despite recent therapeutic advances, notably immunotherapies, the benefit remains limited and restricted to a small percentage of patients. Thus, a better understanding of the disease is needed to identify new therapeutic strategies. Recently, interleukin 7 receptor (IL-7R) has been described as being expressed by MPM cells and associated with poorer patient survival. Thus, the aim of this work was to study the IL-7R/IL-7 pathway in MPM using patient samples. We found that, although more than 40% of MPM cells expressed IL-7R, IL-7 had no effect on their intracellular signaling. Accordingly, the addition of IL-7 to the culture medium did not affect MPM cell growth. Using The Cancer Genome Atlas (TCGA) database, we showed that high IL7 gene expression in MPM tumors was associated with a higher overall patient survival and an induction of genes involved in the immune response. In pleural effusions (PEs), we found that IL-7 concentration was not a good diagnostic biomarker. However, we observed that high IL-7 levels in PEs were associated with shorter survival of MPM patients, but not of lung cancer patients. The prognostic value of IL-7 was also conserved when only patients with epithelioid mesothelioma, the most common histological type of MPM, were analyzed. Taken together, our study suggests that, although the IL-7R/IL-7 signaling pathway is not functional in MPM cells, IL-7 expression in PEs may have prognostic value in MPM patients.},
}
@article {pmid36039621,
year = {2022},
author = {Kenchetty, PK and Balasundaram, S and Rao, K},
title = {An uncommon aetiology for a common clinical problem: Primary pericardial mesothelioma.},
journal = {The National medical journal of India},
volume = {35},
number = {1},
pages = {14-16},
doi = {10.25259/NMJI_273_20},
pmid = {36039621},
issn = {2583-150X},
mesh = {*Asbestos ; *Heart Neoplasms/complications/diagnostic imaging ; Humans ; Male ; *Mesothelioma/etiology/pathology/therapy ; Middle Aged ; Pericardium/diagnostic imaging/pathology ; *Peritoneal Neoplasms ; },
abstract = {Mesothelioma is a tumour arising from the mesothelial cells lining the pleura, pericardium, peritoneum, or the tunica vaginalis of testes. Primary pericardial mesothelioma is a rare tumour that can have varied manifestations and survival in patients with malignant pericardial tumours is generally dismal. The role of asbestos in pericardial mesotheliomas is less well established compared to that in pleural or peritoneal mesotheliomas. The prognosis is generally poor with the treatment options available. We present a middle-aged man with large pericardial effusion secondary to primary pericardial mesothelioma with no previous exposure to asbestos.},
}
@article {pmid36039211,
year = {2022},
author = {Kerosky, ZP and Powell, CR and Lindholm, PC},
title = {Malignant Peritoneal Mesothelioma Presenting with High Protein, High Serum-Ascites Albumin Gradient.},
journal = {Cureus},
volume = {14},
number = {7},
pages = {e27286},
pmid = {36039211},
issn = {2168-8184},
abstract = {Mesothelioma is a difficult-to-detect neoplasm that rarely develops in the peritoneum. In patients with unexplained ascites, pleural fluid analysis and ultrasonography is often the first step to achieving a diagnosis. This case report shares a unique presentation in which a patient who presented with unexplained ascites, was initially thought to have cirrhosis but was later found to have malignant peritoneal mesothelioma after cross-sectional imaging and tissue acquisition. This case illustrates the importance of a high clinical index of suspicion for mesothelioma given its variety of clinical presentations, as well as the utility of early cross-sectional imaging in such cases.},
}
@article {pmid36012262,
year = {2022},
author = {Setlai, BP and Mkhize-Kwitshana, ZL and Mehrotra, R and Mulaudzi, TV and Dlamini, Z},
title = {Microbiomes, Epigenomics, Immune Response, and Splicing Signatures Interplay: Potential Use of Combination of Regulatory Pathways as Targets for Malignant Mesothelioma.},
journal = {International journal of molecular sciences},
volume = {23},
number = {16},
pages = {},
pmid = {36012262},
issn = {1422-0067},
mesh = {*Asbestos/adverse effects ; Epigenomics ; Humans ; Immunity ; *Lung Neoplasms/genetics ; *Mesothelioma/etiology ; *Mesothelioma, Malignant ; *Microbiota ; },
abstract = {Malignant mesotheliomas (MM) are hard to treat malignancies with poor prognosis and high mortality rates. This cancer is highly misdiagnosed in Sub-Saharan African countries. According to literature, the incidence of MM is likely to increase particularly in low-middle-income countries (LMICs). The burden of asbestos-induced diseases was estimated to be about 231,000 per annum. Lack of awareness and implementation of regulatory frameworks to control exposure to asbestos fibers contributes to the expected increase. Exposure to asbestos fibers can lead to cancer initiation by several mechanisms. Asbestos-induced epigenetic modifications of gene expression machinery and non-coding RNAs promote cancer initiation and progression. Furthermore, microbiome-epigenetic interactions control the innate and adaptive immunity causing exacerbation of cancer progression and therapeutic resistance. This review discusses epigenetic mechanisms with more focus on miRNAs and their interaction with the microbiome. The potential use of epigenetic alterations and microbiota as specific biomarkers to aid in the early detection and/or development of therapeutic targets is explored. The advancement of combinatorial therapies to prolong overall patient survival or possible eradication of MM especially if it is detected early is discussed.},
}
@article {pmid36000688,
year = {2022},
author = {Gregório, PHP and Terra, RM and Lima, LP and Pêgo-Fernandes, PM},
title = {Mesothelioma in a developing country: a retrospective analysis of the diagnostic process.},
journal = {Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia},
volume = {48},
number = {5},
pages = {e20220064},
pmid = {36000688},
issn = {1806-3756},
mesh = {*Asbestos/toxicity ; Developing Countries ; Humans ; *Lung Neoplasms/chemically induced/diagnosis/therapy ; *Mesothelioma/diagnosis/etiology/therapy ; *Mesothelioma, Malignant ; Middle Aged ; *Pleural Neoplasms/diagnosis/therapy ; Retrospective Studies ; },
abstract = {OBJECTIVE: To evaluate the process of diagnosing patients with malignant pleural mesothelioma (MPM) at a tertiary care hospital.<br><br>METHODS: This was a retrospective study involving patients referred to a tertiary-care cancer center in Brazil between 2009 and 2020. The diagnostic process was divided into four steps: onset of symptoms, referral to a specialist visit, histopathological diagnosis, and beginning of treatment. The intervals between each phase and the factors for delays were evaluated. Data including clinical status, radiological examinations, staging, treatment modalities, and survival outcomes were collected.<br><br>RESULTS: During the study period, 66 patients (mean age = 64 years) were diagnosed with MPM and underwent treatment. Only 27 (41%) of the patients had knowledge of prior exposure to asbestos. The median number of months (IQR) between the onset of symptoms and the first specialist visit, between the specialist visit and histopathological characterization, and between definite diagnosis and beginning of treatment was, respectively, 6.5 (2.0-11.4), 1.5 (0.6-2.1), and 1.7 (1.2-3.4). The knowledge of prior asbestos exposure was associated with a shorter time to referral to a specialist (median: 214 vs. 120 days; p = 0.04). A substantial number of nondiagnostic procedures and false-negative biopsy results (the majority of which involved the use of Cope needle biopsy) were found to be decisive factors for the length of waiting time. The mean overall survival was 11.9 months.<br><br>CONCLUSIONS: The unfamiliarity of health professionals with MPM and the patient's lack of knowledge of prior asbestos exposure were the major factors to cause a long time interval between the onset of symptoms and beginning of treatment. An overall survival shorter than 1 year is likely to have been due to the aforementioned delays.},
}
@article {pmid35987988,
year = {2022},
author = {Muti, P and Sacconi, A and Pulito, C and Orlandi, G and Donzelli, S and Morrone, A and Jiulian, J and Cox, GP and Kolb, M and Pond, G and Kavsak, P and Levine, MN and Blandino, G and Strano, S},
title = {Artichoke phytocomplex modulates serum microRNAs in patients exposed to asbestos: a first step of a phase II clinical trial.},
journal = {Journal of experimental &amp; clinical cancer research : CR},
volume = {41},
number = {1},
pages = {255},
pmid = {35987988},
issn = {1756-9966},
mesh = {*Asbestos/toxicity ; Biomarkers, Tumor ; *Cynara scolymus ; GPI-Linked Proteins/genetics ; Humans ; *Lung Neoplasms/etiology ; Male ; Mesothelin ; *Mesothelioma/drug therapy/genetics ; *Mesothelioma, Malignant ; *MicroRNAs/genetics ; *Pleural Neoplasms/drug therapy/genetics ; },
abstract = {BACKGROUND: Malignant pleural mesothelioma is a highly aggressive tumor associated with asbestos exposure. There are few effective treatment options for mesothelioma, and patients have a very poor prognosis. Mesothelioma has the potential to represent an appropriate disease to prevent because of its strong association with asbestos exposure and the long latency from exposure to the disease on-set.<br><br>METHODS: In the present study, we tested biological activity and toxicity of an artichoke freeze-dried extract (AWPC) as potential complementary preventive/early stage treatment agent for mesothelioma. This phase II clinical study then was conducted in 18 male-patients with evidence of radiographic characteristics related to asbestos exposure such as asbestosis or benign pleural disease as surrogate disease for mesothelioma clinical model.<br><br>RESULTS: We investigate AWPC biological activity assessing its effect on mesothelin serum level, a glycoprotein with low expression in normal mesothelial cells and high expression in mesothelioma and asbestos related diseases. We also assess the AWPC effect on circulating miRNAs, as novel biomarkers of both cancer risk and response to therapeutic targets. While we found a small and not significant effect of AWPC on mesothelin serum levels, we observed that AWPC intake modulated 11 serum miRNAs related to gene-pathways connected to mesothelioma etiology and development. In terms of toxicity, we also did not observe any severe adverse effects associated to AWPC treatment, only gastro-intestinal symptoms were reported by five study participants.<br><br>CONCLUSIONS: We observed an interesting AWPC effect on miRNAs which targets modulate mesothelioma development. New and much larger clinical studies based on follow-up of workers exposed to asbestos are needed to corroborate the role of AWPC in prevention and early treatment of mesothelioma.<br><br>TRIAL REGISTRATION: ClinicalTrials.gov, NCT02076672 . Registered 03/03/2014.},
}
@article {pmid35978837,
year = {2022},
author = {Jiang, Z and Chen, J and Chen, J and Feng, L and Jin, M and Zhong, H and Ju, L and Zhu, L and Xiao, Y and Jia, Z and Xu, C and Yu, D and Zhang, X and Lou, J},
title = {Mortality due to respiratory system disease and lung cancer among female workers exposed to chrysotile in Eastern China: A cross-sectional study.},
journal = {Frontiers in oncology},
volume = {12},
number = {},
pages = {928839},
pmid = {35978837},
issn = {2234-943X},
abstract = {Female workers in the asbestos processing industry of Eastern China are at high risk of developing multiple types of cancer, and more data are urgently needed to better understand and address this issue. Death certificate data were selected from an asbestos processing city in China from 2005 to 2006. Information was investigated using the relatives of those individuals who had died as sources of information. Individuals were classified into one of three asbestos exposure levels. Standardized mortality ratio and 95% confidence interval were calculated. A total of 2,964 individual deaths were identified from 2005 to 2006; of these, 21.4% were occupationally exposed to asbestos. The main cause of death was circulatory system diseases (21.2%). The proportion of individuals with respiratory system diseases increased by age among each exposure subgroup (P trend < 0.01). Among females, a significant trend was observed between increased asbestos exposure and mortality due to respiratory system diseases and lung cancer. Our study indicated that asbestos exposure was associated with excess mortality from lung cancer and respiratory diseases, particularly among female workers in an asbestos processing area in Eastern China.},
}
@article {pmid35941734,
year = {2022},
author = {Silvestri, S and Ciapini, C and Innocenti, A},
title = {Past Asbestos Exposure in Rolling Stock Manufacturing in the Absence of Environmental Monitoring: An Original Method.},
journal = {Journal of occupational and environmental medicine},
volume = {64},
number = {10},
pages = {e635-e640},
doi = {10.1097/JOM.0000000000002656},
pmid = {35941734},
issn = {1536-5948},
mesh = {*Asbestos ; Cohort Studies ; Environmental Monitoring ; Humans ; *Mesothelioma ; *Occupational Diseases ; *Occupational Exposure/adverse effects/analysis ; },
abstract = {OBJECTIVE: The aim of this study is the reconstruction of asbestos exposure in absence of environmental monitoring data, to use the results in a cohort study of railway rolling stock workers.<br><br>METHODS: To reconstruct past exposures, the production data (number of rolling stock and asbestos content) and working methods were reconstructed with former employees and company documentation, literature data, and author expertise.<br><br>RESULTS: The result of the work is a job/exposure matrix from 1956 to 1979, when sprayed asbestos was used as insulator of the metal bodies. Annual exposure estimate varies from 0.08 to 4.9 fb/mL depending on the specific jobs. Thirty-one mesotheliomas with occupational exposure, one with environmental and one with family exposures, were identified.<br><br>CONCLUSIONS: The originality of the study consists on the use of company production data to establish frequency duration of asbestos exposure.},
}
@article {pmid35940275,
year = {2023},
author = {Chun, CP and Song, LX and Zhang, HP and Guo, DD and Xu, GX and Li, Y and Xin, X and Cao, J and Li, F},
title = {Malignant peritoneal mesothelioma.},
journal = {The American journal of the medical sciences},
volume = {365},
number = {1},
pages = {99-103},
doi = {10.1016/j.amjms.2022.07.008},
pmid = {35940275},
issn = {1538-2990},
mesh = {Male ; Humans ; Aged ; *Mesothelioma, Malignant/complications ; Ascites/diagnostic imaging/etiology ; *Mesothelioma/diagnosis/etiology/pathology ; *Asbestos/toxicity ; *Pleural Neoplasms/diagnosis ; *Peritoneal Neoplasms/diagnosis/etiology/pathology ; },
abstract = {Malignant peritoneal mesothelioma (MPM) is a rare, life-threatening malignant tumor. We present a report of a rare case of a 67-year-old male patient with MPM and severe abdominal pain, bloating, and bloody ascites as manifestations. The diagnosis was confirmed by cytology of ascites aspiration fluid and further verified by laparoscopic exploratory biopsy. The characteristics of signs and clinical manifestations in this case are less common. As everyone knows, asbestos exposure is usually associated with pleural mesothelioma, but only 6%-10% of malignant mesothelioma cases originate from the peritoneum, which is far less than pleural mesothelioma. Generally, its non-specificity provides a huge challenge to medical professionals in its diagnosis, and this is also the main reason for delayed diagnosis. Patients should be vigilant, even though no clear risk factor is observed.},
}
@article {pmid35937383,
year = {2022},
author = {Shobana, M and Balasraswathi, VR and Radhika, R and Oleiwi, AK and Chaudhury, S and Ladkat, AS and Naved, M and Rahmani, AW},
title = {Classification and Detection of Mesothelioma Cancer Using Feature Selection-Enabled Machine Learning Technique.},
journal = {BioMed research international},
volume = {2022},
number = {},
pages = {9900668},
pmid = {35937383},
issn = {2314-6141},
mesh = {Algorithms ; Bayes Theorem ; Humans ; *Machine Learning ; *Mesothelioma/classification/diagnosis ; Mesothelioma, Malignant/diagnosis ; Multiple Myeloma/diagnosis ; },
abstract = {Cancer of the mesothelium, sometimes referred to as malignant mesothelioma (MM), is an extremely uncommon form of the illness that almost always results in death. Chemotherapy, surgery, radiation therapy, and immunotherapy are all potential treatments for multiple myeloma; however, the majority of patients are identified with the disease at an advanced stage, at which time it is resistant to these therapies. After obtaining a diagnosis of advanced multiple myeloma, the average length of time that a person lives is one year after hearing this news. There is a substantial link between asbestos exposure and mesothelioma (MM). Using an approach that enables feature selection and machine learning, this article proposes a classification and detection method for mesothelioma cancer. The CFS correlation-based feature selection approach is first used in the feature selection process. It acts as a filter, selecting just the traits that are relevant to the categorization. The accuracy of the categorization model is improved as a direct consequence of this. After that, classification is carried out with the help of naive Bayes, fuzzy SVM, and the ID3 algorithm. Various metrics have been utilized during the process of measuring the effectiveness of machine learning strategies. It has been discovered that the choice of features has a substantial influence on the accuracy of the categorization.},
}
@article {pmid35931425,
year = {2022},
author = {Røe, OD and Creaney, J and , },
title = {Response to "Revisiting 'BAP1ness' in Malignant Pleural Mesothelioma".},
journal = {Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
volume = {17},
number = {8},
pages = {e69-e70},
doi = {10.1016/j.jtho.2022.05.013},
pmid = {35931425},
issn = {1556-1380},
mesh = {Humans ; *Lung Neoplasms/genetics/pathology ; *Mesothelioma/pathology ; *Mesothelioma, Malignant ; *Pleural Neoplasms/pathology ; },
}
@article {pmid35931423,
year = {2022},
author = {Yang, H and Gaudino, G and Bardelli, F and Carbone, M},
title = {Does the Amount of Asbestos Exposure Influence Prognosis?.},
journal = {Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
volume = {17},
number = {8},
pages = {949-952},
doi = {10.1016/j.jtho.2022.06.003},
pmid = {35931423},
issn = {1556-1380},
mesh = {*Asbestos/adverse effects ; Humans ; *Lung Neoplasms/etiology ; *Mesothelioma/etiology ; *Occupational Exposure/adverse effects ; Prognosis ; },
}
@article {pmid35911327,
year = {2022},
author = {Tachibana, M and Nozawa, M and Kamimura, K and Tsutsumi, Y},
title = {Synchronous Jejunal Sarcomatoid Carcinoma and Incidentally Associated Localized Peritoneal Malignant Mesothelioma.},
journal = {Cureus},
volume = {14},
number = {6},
pages = {e26270},
pmid = {35911327},
issn = {2168-8184},
abstract = {Sarcomatoid carcinoma (SCA) of the small bowel is a rare aggressive variant of small intestinal cancer accompanying a poor prognosis. The tumor primarily affects middle-aged and elderly patients. We report herein a 67-year-old Japanese male who manifested anemia. He had a history of asbestos exposure 30 years earlier. An abdominal computed tomography (CT) scan showed a 6.5-cm aneurysmal, dilated mass of the small intestine. Capsule endoscopy revealed a large circumferential hemorrhagic ulcerative lesion in the jejunum. Biopsy indicated sarcomatoid carcinoma, and partial resection of the small bowel and adjacent transverse colon and omentum was performed. In addition to the T3N0M0 jejunal giant sarcomatoid carcinoma (SCA), a 3-mm small localized peritoneal (omental) malignant mesothelioma (LMM) was also incidentally included. Synchronous presentation of small intestinal and mesothelial malignancies is extremely rare, and the avoidance of incorrect clinical staging is critically important. Surgical resection is still considered the best first-line therapy, because of a poor response to chemotherapy and radiotherapy. Dual-color fluorescent in situ hybridization (FISH) for p16/CDKN2A and chromosome 9 indicated homologous deletion of p16/CDKN2A in SCA and a normal pattern in LMM. Methylthioadenosine phosphorylase (MTAP) was negative in SCA but positive in LMM. Both tumors consistently expressed BRCA1-associated protein 1 (BAP1). Tumor necrosis factor receptor-associated factor 7 (TRAF7) was suppressed, and neural cell adhesion molecule L1 precursor (NCAML1/L1CAM) was agitated in both tumors. Diffuse and strong expression of programmed death-ligand 1 (PD-L1) and the association of tumor-infiltrating lymphocytes in SCA may indicate a potential for PD-L1-targeted immunotherapy for treating this type of aggressive cancer. PD-L1 was focally expressed in LMM. The postoperative course was uneventful for two years.},
}
@article {pmid35908620,
year = {2022},
author = {Parvathaneni, V and Chilamakuri, R and Kulkarni, NS and Wang, X and Agarwal, S and Gupta, V},
title = {Repurposing clofazimine for malignant pleural mesothelioma treatment - In-vitro assessment of efficacy and mechanism of action.},
journal = {Life sciences},
volume = {306},
number = {},
pages = {120843},
doi = {10.1016/j.lfs.2022.120843},
pmid = {35908620},
issn = {1879-0631},
mesh = {*Antineoplastic Agents/pharmacology/therapeutic use ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Clofazimine/pharmacology/therapeutic use ; Drug Repositioning ; Humans ; *Lung Neoplasms/pathology ; *Mesothelioma/drug therapy/metabolism ; *Mesothelioma, Malignant ; *Pleural Neoplasms/drug therapy/metabolism/pathology ; beta Catenin ; },
abstract = {AIMS: Malignant pleural mesothelioma (MPM) is a rare cancer of lungs' pleural cavity, with minimally effective therapies available. Thus, there exists a necessity for drug repurposing which is an attractive strategy for drug development in MPM. Repurposing of an old FDA-approved anti-leprotic drug, Clofazimine (CFZ), presents an outstanding opportunity to explore its efficacy in treating MPM.<br><br>MAIN METHODS: Cytotoxicity, scratch assay, and clonogenic assays were employed to determine CFZ's ability to inhibit cell viability, cell migration, and colony growth. 3D Spheroid cell culture studies were performed to identify tumor growth inhibition potential of CFZ in MSTO-211H cell line. Gene expression analysis was performed using RT-qPCR assays to determine the CFZ's effect of key genes. Western blot studies were performed to determine CFZ's ability to induce apoptosis its effect to induce autophagy marker.<br><br>KEY FINDINGS: CFZ showed significant cytotoxicity against both immortalized and primary patient-derived cell lines with IC50 values ranging from 3.4&#xa0;&#x3bc;M (MSTO-211H) to 7.1&#xa0;&#x3bc;M (HAY). CFZ significantly impaired MPM cell cloning efficiency, migration, and tumor spheroid formation. 3D Spheroid model showed that CFZ resulted in reduction in spheroid volume. RT-qPCR data showed downregulation of genes &#x3b2;-catenin, BCL-9, and PRDX1; and upregulation of apoptosis markers such as PARP, Cleaved caspase 3, and AXIN2. Additionally, immunoblot analysis showed that CFZ down-regulates the expression of &#x3b2;-catenin (apoptosis induction) and up-regulates p62, LC3B protein II (autophagy inhibition).<br><br>SIGNIFICANCE: It can be concluded that CFZ could be a promising molecule to repurpose for MPM treatment which needs numerous efforts from further studies.},
}
@article {pmid35906513,
year = {2022},
author = {Dubois, F and Bazille, C and Levallet, J and Maille, E and Brosseau, S and Madelaine, J and Bergot, E and Zalcman, G and Levallet, G},
title = {Molecular Alterations in Malignant Pleural Mesothelioma: A Hope for Effective Treatment by Targeting YAP.},
journal = {Targeted oncology},
volume = {17},
number = {4},
pages = {407-431},
pmid = {35906513},
issn = {1776-260X},
mesh = {Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; *Asbestos ; Bevacizumab/therapeutic use ; Humans ; *Lung Neoplasms/drug therapy ; *Mesothelioma/drug therapy/pathology ; *Mesothelioma, Malignant ; Pemetrexed/therapeutic use ; *Pleural Neoplasms/drug therapy/pathology ; },
abstract = {Malignant pleural mesothelioma is a rare and aggressive neoplasm, which has primarily been attributed to the exposure to asbestos fibers (83% of cases); yet, despite a ban of using asbestos in many countries, the incidence of malignant pleural mesothelioma failed to decline worldwide. While little progress has been made in malignant pleural mesothelioma diagnosis, bevacizumab at first, then followed by double immunotherapy (nivolumab plus ipilumumab), were all shown to improve survival in large phase III randomized trials. The morphological analysis of the histological subtyping remains the primary indicator for therapeutic decision making at an advanced disease stage, while a platinum-based chemotherapy regimen combined with pemetrexed, either with or without bevacizumab, is still the main treatment option. Consequently, malignant pleural mesothelioma still represents a significant health concern owing to poor median survival (12-18 months). Given this context, both diagnosis and therapy improvements require better knowledge of the molecular mechanisms underlying malignant pleural mesothelioma's carcinogenesis and progression. Hence, the Hippo pathway in malignant pleural mesothelioma initiation and progression has recently received increasing attention, as the aberrant expression of its core components may be closely related to patient prognosis. The purpose of this review was to provide a critical analysis of our current knowledge on these topics, the main focus being on the available evidence concerning the role of each Hippo pathway's member as a promising biomarker, enabling detection of the disease at earlier stages and thus improving prognosis.},
}
@article {pmid35885614,
year = {2022},
author = {Sculco, M and La Vecchia, M and Aspesi, A and Clavenna, MG and Salvo, M and Borgonovi, G and Pittaro, A and Witel, G and Napoli, F and Listì, A and Grosso, F and Libener, R and Maconi, A and Rena, O and Boldorini, R and Giachino, D and Bironzo, P and Maffè, A and Alì, G and Elefanti, L and Menin, C and Righi, L and Tampieri, C and Scagliotti, GV and Dianzani, C and Ferrante, D and Migliore, E and Magnani, C and Mirabelli, D and Matullo, G and Dianzani, I},
title = {Diagnostics of BAP1-Tumor Predisposition Syndrome by a Multitesting Approach: A Ten-Year-Long Experience.},
journal = {Diagnostics (Basel, Switzerland)},
volume = {12},
number = {7},
pages = {},
pmid = {35885614},
issn = {2075-4418},
support = {21390//Italian Association for Cancer Research/ ; 23760//Italian Association for Cancer Research/ ; //This research was funded by the offer of compensation to the inhabitants of Casale Monferrato deceased or affected by mesothelioma - HERMES (HEreditary Risk in MESothelioma)/ ; //The APC was funded by the Italian Ministry of Education, University and Research (MIUR) program &quot;Departments of Excellence 2018-2022&quot;, FOHN Project - Department of Health Sciences, Universit&#xe0; del Piemonte Orientale/ ; },
abstract = {Germline mutations in the tumor suppressor gene BRCA1-associated protein-1 (BAP1) lead to BAP1 tumor predisposition syndrome (BAP1-TPDS), characterized by high susceptibility to several tumor types, chiefly melanoma, mesothelioma, renal cell carcinoma, and basal cell carcinoma. Here, we present the results of our ten-year experience in the molecular diagnosis of BAP1-TPDS, along with a clinical update and cascade genetic testing of previously reported BAP1-TPDS patients and their relatives. Specifically, we sequenced germline DNA samples from 101 individuals with suspected BAP1-TPDS and validated pathogenic variants (PVs) by assessing BAP1 somatic loss in matching tumor specimens. Overall, we identified seven patients (7/101, 6.9%) carrying six different germline BAP1 PVs, including one novel variant. Consistently, cascade testing revealed a total of seven BAP1 PV carriers. In addition, we explored the mutational burden of BAP1-TPDS tumors by targeted next-generation sequencing. Lastly, we found that certain tumors present in PV carriers retain a wild-type BAP1 allele, suggesting a sporadic origin of these tumors or a functional role of heterozygous BAP1 in neoplastic development. Altogether, our findings have important clinical implications for therapeutic response of BAP1-TPDS patients.},
}
@article {pmid35883451,
year = {2022},
author = {Pandey, SK and Machlof-Cohen, R and Santhanam, M and Shteinfer-Kuzmine, A and Shoshan-Barmatz, V},
title = {Silencing VDAC1 to Treat Mesothelioma Cancer: Tumor Reprograming and Altering Tumor Hallmarks.},
journal = {Biomolecules},
volume = {12},
number = {7},
pages = {},
pmid = {35883451},
issn = {2218-273X},
mesh = {Animals ; Apoptosis ; Humans ; Inflammation ; *Mesothelioma/genetics/therapy ; Mice ; *Nanotubes, Carbon ; RNA, Small Interfering/metabolism ; Tumor Microenvironment ; Voltage-Dependent Anion Channel 1/genetics/metabolism ; },
abstract = {Mesothelioma, an aggressive cancer with a poor prognosis, is linked to asbestos exposure. However, carbon nanotubes found in materials we are exposed to daily can cause mesothelioma cancer. Cancer cells reprogram their metabolism to support increased biosynthetic and energy demands required for their growth and motility. Here, we examined the effects of silencing the expression of the voltage-dependent anion channel 1 (VDAC1), controlling the metabolic and energetic crosstalk between mitochondria and the rest of the cell. We demonstrate that VDAC1 is overexpressed in mesothelioma patients; its levels increase with disease stage and are associated with low survival rates. Silencing VDAC1 expression using a specific siRNA identifying both mouse and human VDAC1 (si-m/hVDAC1-B) inhibits cell proliferation of mesothelioma cancer cells. Treatment of xenografts of human-derived H226 cells or mouse-derived AB1 cells with si-m/hVDAC1-B inhibited tumor growth and caused metabolism reprogramming, as reflected in the decreased expression of metabolism-related proteins, including glycolytic and tricarboxylic acid (-)cycle enzymes and the ATP-synthesizing enzyme. In addition, tumors depleted of VDAC1 showed altered microenvironments and inflammation, both associated with cancer progression. Finally, tumor VDAC1 silencing also eliminated cancer stem cells and induced cell differentiation to normal-like cells. The results show that silencing VDAC1 expression leads to reprogrammed metabolism and to multiple effects from tumor growth inhibition to modulation of the tumor microenvironment and inflammation, inducing differentiation of malignant cells. Thus, silencing VDAC1 is a potential therapeutic approach to treating mesothelioma.},
}
@article {pmid35880098,
year = {2022},
author = {Di Marzio, N and Ananthanarayanan, P and Guex, AG and Alini, M and Riganti, C and Serra, T},
title = {Sound-based assembly of a microcapillary network in a saturn-like tumor model for drug testing.},
journal = {Materials today. Bio},
volume = {16},
number = {},
pages = {100357},
pmid = {35880098},
issn = {2590-0064},
abstract = {The tumor microenvironment (TME), consisting of extracellular matrix, proteins, stromal cells, and a vascular system, is reported to have a key role in cancer progression and prognosis. Thereby, the interaction between the vascular network and tumor mass is an important feature of the TME since the anticancer agents which are delivered to the TME can trigger the vascular response and influence the therapeutic outcome of the treatment. To identify and develop new therapeutic strategies, 3D in vitro models that recapitulate the complexity of the TME are urgently needed. Among them, vascularized tumor models are a promising approach, allowing to target tumor angiogenesis and reduce tumor growth. By using sound patterning, cells can be condensed locally into highly reproducible patterns through the action of mild hydrodynamic forces. Here, we use a soundwave-driven cell assembly approach to create a ring-shaped microcapillary network in fibrin hydrogel. Then, we generate a 3D vascularized tumor model by combining a tumor heterotypic spheroid, consisting of fibroblasts and Malignant Pleural Mesothelioma (MPM) cells, with the surrounding vascular ring. Based on its shape, we name it Saturn-like vascularized Tumor Model (STM). The growth of the microcapillary network is monitored over time by fluorescence imaging. The area covered by the microcapillary network, and its continuous increase in presence of the heterotypic tumor spheroid was monitored. Interestingly, this effect is enhanced when treating the STM with the anticancer agent Cisplatin. Overall, we show the use of sound patterning as a fast and cell-friendly approach to spatially organize and condense cells, to generate a 3D in vitro platform from which simple readouts of drug tests can be extracted by image analysis, with the potential to provide a model system for tailored tumor therapy.},
}
@article {pmid35876593,
year = {2022},
author = {Urban, M and Pelclová, D and Urban, P and Vít, M and Urban, P and Fenclová, Z},
title = {Asbestos danger in central Europe is not yet over - the situation in the Czech Republic.},
journal = {Central European journal of public health},
volume = {30},
number = {2},
pages = {67-73},
pmid = {35876593},
issn = {1210-7778},
mesh = {*Asbestos/toxicity ; Asbestosis/epidemiology ; Czech Republic/epidemiology ; Humans ; Lung Neoplasms/epidemiology ; Mesothelioma/epidemiology ; *Occupational Diseases/epidemiology ; *Occupational Exposure/adverse effects ; Retrospective Studies ; },
abstract = {OBJECTIVES: In the Czech Republic, asbestos has been classified as a known human carcinogen since 1984. The use of asbestos-containing products was limited to scenarios where the use of other materials was not possible. Since 1997, the manufacture of asbestos materials has been forbidden, and in 1999, the import, manufacture and distribution of all types of asbestos fibres was legally banned by Act No. 157/1998 Coll. Although the use of asbestos is forbidden, the risk of exposure still exists given the ongoing demolition and reconstruction of buildings in which asbestos has been used. In addition, a novel risk has arisen through the quarrying of asbestos-containing aggregates and their subsequent use. The aim of this paper was to describe and evaluate asbestos in terms of history, legislation, current risk of occupational exposure and its health consequences in the Czech Republic over the last three decades.<br><br>METHODS: This retrospective descriptive study used the collected data on occupational exposure and occupational diseases. The counts of workers occupationally exposed to asbestos were obtained from the Registry of Work Categorization; the numbers and structure of occupational diseases caused by asbestos were taken from the Czech National Registry of Occupational Diseases. Data on the total number of mesothelioma cases recorded in the Czech National Cancer Registry was provided by the Institute of Health Information and Statistics of the Czech Republic.<br><br>RESULTS: A total of 13,112 subjects were registered as occupationally exposed to asbestos during the period 2001-2020. A total of 687 cases of asbestos-related occupational diseases were reported in the period 1991-2020 in the Czech Republic, comprising 178 cases of asbestosis, 250 cases of pleural hyalinosis, 168 cases of pleural or peritoneal mesothelioma, 90 cases of lung cancer, and one case of laryngeal cancer. The data from the Czech National Cancer Registry, available for a shorter period (1991-2018), reveal 1,389 cases of mesothelioma, of which only ~11% were recognised as occupational, despite the fact that the occupational causality of mesotheliomas is estimated to be up to 90% of mesotheliomas. Moreover, the latency of mesotheliomas since the last occupational exposure reached up to 50 years and this trend is still slightly increasing, unlike asbestosis, where a high cumulative dose of inhaled asbestos is needed. The real proportion of occupational lung cancers may obviously be even higher, especially in smokers, where occupational causes including asbestos are not suspected by most physicians.<br><br>CONCLUSION: Czech data on asbestos-related occupational diseases, especially cancers, are grossly underestimated, which is most apparent through the low proportion of mesotheliomas diagnosed as occupational. Asbestos materials in older buildings remained in situ and may represent a danger during reconstruction works. The current source of exposure appears to be quarrying of asbestos-containing aggregate and its subsequent use. Awareness of the professional community is therefore crucial, not only for the possibility of compensating those affected, but also for the early detection of the diseases through the dispensary of exposed persons.},
}
@article {pmid35874636,
year = {2022},
author = {Mazzoni, E and Bononi, I and Rotondo, JC and Mazziotta, C and Libener, R and Guaschino, R and Gafà, R and Lanza, G and Martini, F and Tognon, M},
title = {Sera from Patients with Malignant Pleural Mesothelioma Tested Positive for IgG Antibodies against SV40 Large T Antigen: The Viral Oncoprotein.},
journal = {Journal of oncology},
volume = {2022},
number = {},
pages = {7249912},
pmid = {35874636},
issn = {1687-8450},
abstract = {Malignant pleural mesothelioma (MPM), a fatal tumor, is mainly linked to the asbestos exposure. It has been reported that together with the inhalation of asbestos fibers, other factors are involved in the MPM onset, including simian virus 40 (SV40). SV40, a polyomavirus with oncogenic potential, induces (i) in vitro the mesenchymal cell transformation, whereas (ii) in vivo the MPM onset in experimental animals. The association between MPM and SV40 in humans remains to be elucidated. Sera (n = 415) from MPM-affected patients (MPM cohort 1; n = 152) and healthy subjects (HSs, n = 263) were investigated for their immunoglobulin G (IgG) against simian virus 40 large tumor antigen (Tag), which is the transforming protein. Sera were investigated with an indirect enzyme-linked immunosorbent assay (ELISA) using two synthetic peptides from SV40 Tag protein. SV40 Tag protein was evaluated by immunohistochemical (IHC) staining on MPM samples (MPM cohort 2; n = 20). Formalin-fixed and paraffin-embedded (FFPE) samples were obtained from MPM patients unrelated to MPM serum donors. The proportion of sera, from MPM patients, showing antibodies against SV40 Tag (34%) was significantly higher compared to HSs (20%) (odds ratio 2.049, CI 95% 1.32-3.224; p=0.0026). Immunohistochemical staining (IHS) assays showed SV40 Tag expression in 8/20, 40% of MPM specimens. These results indicate that SV40 is linked to a large fraction of MPM. It is worth noting that the prevalence of SV40 Tag antibodies detected in sera from cohort 1 of MPM patients is similar to the prevalence of SV40 Tag found to be expressed in FFPE tissues from MPM cohort 2.},
}
@article {pmid35863303,
year = {2022},
author = {Thives, LP and Ghisi, E and Thives Júnior, JJ and Vieira, AS},
title = {Is asbestos still a problem in the world? A current review.},
journal = {Journal of environmental management},
volume = {319},
number = {},
pages = {115716},
doi = {10.1016/j.jenvman.2022.115716},
pmid = {35863303},
issn = {1095-8630},
mesh = {*Asbestos ; Commerce ; Humans ; International Cooperation ; *Mesothelioma/epidemiology/etiology ; *Occupational Exposure ; },
abstract = {Asbestos has been used by automobile, construction, manufacturing, power, and chemical industries for many years due to its particular properties, i.e. high tensile strength, non-flammable, thermal and electrical resistance and stability, and chemical resistance. However, such a mineral causes harmful effects to human health, including different types of cancer (e.g., mesothelioma). As a result, the use of asbestos has been banned since the 1980s in many countries. Nonetheless, asbestos is still part of the daily life of the population as asbestos-containing materials (ACMs) are still present in many buildings constructed and renovated before the 1990s. This work aims to present a current literature review about asbestos. The literature review was composed mainly of research articles published in international journals from the medical and engineering disciplines to provide an overview of asbestos use effects reported in interdisciplinary areas. The literature review comprised asbestos characteristics and its relationship to the risks of human exposure, countries where asbestos use is permitted or banned, reducing asbestos in the built environment, and environmental impact due to use and disposal of asbestos. The main findings were that ACMs are still responsible for severe human diseases, particularly in areas where there is a lack of coordinated asbestos management plans, reduced awareness about asbestos health risks, or even a delay in the implementation of asbestos-ban. Such issues may be more prevailing in developing countries. The current research in many countries contemplates several methodologies and techniques to process ACMs into inert and recyclable materials. The identification and coordinated management of ACM hazardous waste is a significant challenge to be faced by countries, and its inadequate disposal causes severe risk of exposure to asbestos fibres. Based on this work, it was concluded that banning asbestos is indicated in all countries in the world.},
}
@article {pmid35859704,
year = {2022},
author = {Kumar, N and Natrayan, L and Kasirajan, G and Kaliappan, S and Raj Kamal, MD and Patil, PP and Chewaka, MD},
title = {Development of Novel Bio-mulberry-Reinforced Polyacrylonitrile (PAN) Fibre Organic Brake Friction Composite Materials.},
journal = {Bioinorganic chemistry and applications},
volume = {2022},
number = {},
pages = {6426763},
pmid = {35859704},
issn = {1565-3633},
abstract = {Natural fibre reinforcement is used in important sectors such as medical, aerospace, automobile, and many other fields. Many articles have reported that natural fibre has the potential to replace synthetic fibres. Natural fibre reinforcement has given good results as a brake friction material. It has already been proven that asbestos causes lung cancer and mesothelioma in brakes. Many people died from the effects of asbestos. According to the World Health Organization's trending brake report, this material leads to serious health issues. This work is going on for the replacement of these materials. Mulberry fibre is a unique material, and PAN fibre is combined with mulberry fibre and used as a brake reinforcement material to replace Kevlar fibre. The brake pads were fabricated with the various wt% of mulberry fibres and PAN fibre [3-12%] with an equal ratio and aramid fibre [3-6%] in the hydraulic hind brake moulding machine. The mechanical, chemical, physical, tribological, and thermal properties were evaluated. MF-2 [6 wt%] mulberry-PAN-fibre-based brake pad composites have shown better results for ultimate shear strength and proof stress, tensile strength, compressive strength, and impact energy.},
}
@article {pmid35852497,
year = {2022},
author = {Price, B},
title = {Projection of future numbers of mesothelioma cases in the US and the increasing prevalence of background cases: an update based on SEER data for 1975 through 2018.},
journal = {Critical reviews in toxicology},
volume = {52},
number = {4},
pages = {317-324},
doi = {10.1080/10408444.2022.2082919},
pmid = {35852497},
issn = {1547-6898},
mesh = {*Asbestos/toxicity ; Humans ; Incidence ; *Mesothelioma/epidemiology ; *Mesothelioma, Malignant ; *Pleural Neoplasms/epidemiology/etiology/pathology ; Prevalence ; },
abstract = {Historically, mesothelioma, which is almost exclusively a cancer of the pleura or peritoneum, has been referred to as a sentinel disease for asbestos exposure meaning that the disease is an epidemiologic marker for asbestos. This description of mesothelioma often has been misinterpreted to mean that the only risk factor for mesothelioma is asbestos. In addition to a few risk factors other than asbestos, in the US, background mesotheliomas, i.e. mesothelioma cases that are a consequence of spontaneous tumor formation, are the most prevalent number of cases after asbestos-associated cases.[1] My analysis of SEER data for 1973 through 2005 published in 2009 projected that around 2040 virtually all mesothelioma cases in the US will be background cases. The update here, which is based on the most current SEER data, 1975 through 2018, and the same methods used in 2009 shows that the pattern of mesothelioma incidence is unchanged. Further, in general agreement with the analysis published in 2009, after 2040 virtually all mesothelioma cases, currently estimated to be approximately 1600 per year, will be background cases.},
}
@article {pmid35840292,
year = {2022},
author = {Henshall, C and Dawson, P and Rahman, N and Ball, H and Sundralingam, A and Shahidi, M and McKeown, E and Park, J and Walthall, H and Davey, Z},
title = {Understanding clinical decision-making in mesothelioma care: a mixed methods study.},
journal = {BMJ open respiratory research},
volume = {9},
number = {1},
pages = {},
pmid = {35840292},
issn = {2052-4439},
mesh = {*COVID-19 ; Clinical Decision-Making ; Humans ; *Mesothelioma/diagnosis ; *Mesothelioma, Malignant ; State Medicine ; },
abstract = {INTRODUCTION: Malignant pleural mesothelioma is a rare, incurable cancer arising from previous asbestos exposure; patients have a poor prognosis, with a median survival rate of 8-14 months. Variation in mesothelioma clinical decision-making remains common with a lack of multidisciplinary knowledge sharing, leading to inconsistencies in treatment decisions. The study aimed to explore which factors impacted on clinicians' decision-making in mesothelioma care, with a view to optimising the mesothelioma care pathway.<br><br>METHODS: This mixed methods study consisted of documentary analysis of local and national guidelines, policies or documents pertaining to mesothelioma care pathways, secondary analysis of mesothelioma patient data, and interviews with clinicians attending lung cancer and/or mesothelioma-specific multidisciplinary team meetings. The study took place at three National Health Service trusts in England. Documentations relating to patients' treatment pathways were collated and reviewed qualitatively. Records of patients with mesothelioma were extracted from hospital patient records and data collected on diagnosis date, treatment, mortality rates, survival postdiagnosis, age and clinical care team. Data were statistically analysed. Interviews with clinicians explored influences on clinical decision-making, including challenges or barriers involved. Data were thematically analysed. The Strengthening the Reporting of Observational Studies in Epidemiology reporting checklist was used.<br><br>RESULTS: There were differences in the structure and delivery of mesothelioma treatment and care between trusts. Four main themes were identified: 'collaboration and communication', 'evidence base and knowledge', 'role of the clinician' and 'role of the patient'. Two cross-cutting themes relating to the role of the mesothelioma nurse specialist and the impact of COVID-19 were identified.<br><br>DISCUSSION: There is a need to review the structure of mesothelioma multidisciplinary team meetings to ensure patients are reviewed by clinicians with appropriate knowledge, expertise and understanding of how, why and when decisions should be made. There is a need for expert clinicians in mesothelioma care to promote an up-to-date evidence and knowledge base within the wider multidisciplinary team.},
}
@article {pmid35815188,
year = {2022},
author = {Ma, GY and Shi, S and Wang, P and Wang, XG and Zhang, ZG},
title = {Clinical significance of 9P21 gene combined with BAP1 and MTAP protein expression in diagnosis and prognosis of mesothelioma serous effusion.},
journal = {Biomedical reports},
volume = {17},
number = {2},
pages = {66},
pmid = {35815188},
issn = {2049-9442},
abstract = {The diagnostic value of the 9P21 gene determined using fluorescence in situ hybridization (FISH) combined with BRCA1-associated protein 1 (BAP1) and methylthioadenosine phosphorylase (MTAP) expression detection by immunohistochemistry, was investigated in serous effusion samples of malignant mesothelioma. A total of 70 serous disease samples with serous effusion were collected from June 2017 to June 2020. Following biopsy specimen pathological diagnosis, samples were divided into malignant mesothelioma and benign mesothelioma. Differential expression of BAP1 and MTAP genes were identified in mesothelioma and mesenchymal hyperplasia. The 9P21 gene fragment was lost in mesothelioma. The positive rates of FISH, BAP1 and MTAP in biopsy specimens were 98.00, 94.00 and 90.00%. The specificity of the three were 96.00, 85.71 and 77.27%, the sensitivity were 90.00, 95.92 and 93.75%, and the positive rate of the combined detection of the three was 93.33%. The positive rate of serous fluid samples detected by the three methods (9P21 FISH probe combined with BAP1 and MTAP expression detected immunohistochemically) was 96.00, 92.00 and 88.00%, the specificity were 90.00, 77.27 and 71.43%, the sensitivity was 96.00, 93.75 and 89.80%, and the positive rate of the three combined detections was 91.33%. It was demonstrated that there was a high consistency between serous fluid samples and biopsy samples. According to clinicopathological analysis, sex, age, lesion site, Ki67 had little association with the occurrence and development of malignant mesothelioma, while asbestos exposure history was closely associated to the occurrence of mesothelioma. A high level of BAP1 gene was positively associated with the prognosis of mesothelioma, while a high level of MTAP gene was negatively associated with the prognosis of mesothelioma (P<0.05). Therefore, 9P21 FISH probe combined with BAP1 and MTAP can be used as a new method for the detection of malignant mesothelioma, and provide an important basis for the early diagnosis of mesothelioma.},
}
@article {pmid35804954,
year = {2022},
author = {Janssens, E and Schillebeeckx, E and Zwijsen, K and Raskin, J and Van Cleemput, J and Surmont, VF and Nackaerts, K and Marcq, E and van Meerbeeck, JP and Lamote, K},
title = {External Validation of a Breath-Based Prediction Model for Malignant Pleural Mesothelioma.},
journal = {Cancers},
volume = {14},
number = {13},
pages = {},
pmid = {35804954},
issn = {2072-6694},
support = {grants KOTK UA/2016/10710/1 and 'Emmanuel van der Schueren'//Kom op tegen Kanker (Stand up to Cancer), the Flemish cancer society/ ; },
abstract = {During the past decade, volatile organic compounds (VOCs) in exhaled breath have emerged as promising biomarkers for malignant pleural mesothelioma (MPM). However, as these biomarkers lack external validation, no breath test for MPM has been implemented in clinical practice. To address this issue, we performed the first external validation of a VOC-based prediction model for MPM. The external validation cohort was prospectively recruited, consisting of 47 MPM patients and 76 asbestos-exposed (AEx) controls. The predictive performance of the previously developed model was assessed by determining the degree of agreement between the predicted and actual outcome of the participants (patient/control). Additionally, to optimise the performance, the model was updated by refitting it to the validation cohort. External validation revealed a poor performance of the original model as the accuracy was estimated at only 41%, indicating poor generalisability. However, subsequent updating of the model improved the differentiation between MPM patients and AEx controls significantly (73% accuracy, 92% sensitivity, and 92% negative predictive value), substantiating the validity of the original predictors. This updated model will be more generalisable to the target population and exhibits key characteristics of a potential screening test for MPM, which could significantly impact MPM management.},
}
@article {pmid35804881,
year = {2022},
author = {Song, Y and Baxter, SS and Dai, L and Sanders, C and Burkett, S and Baugher, RN and Mellott, SD and Young, TB and Lawhorn, HE and Difilippantonio, S and Karim, B and Kadariya, Y and Pinto, LA and Testa, JR and Shoemaker, RH},
title = {Mesothelioma Mouse Models with Mixed Genomic States of Chromosome and Microsatellite Instability.},
journal = {Cancers},
volume = {14},
number = {13},
pages = {},
pmid = {35804881},
issn = {2072-6694},
support = {HHSN261201500003C/CA/NCI NIH HHS/United States ; R01 CA148805/CA/NCI NIH HHS/United States ; HHSN261201500003I/CA/NCI NIH HHS/United States ; CA06927/CA/NCI NIH HHS/United States ; P30 CA006927/CA/NCI NIH HHS/United States ; CA148805/CA/NCI NIH HHS/United States ; },
abstract = {Malignant mesothelioma (MMe) is a rare malignancy originating from the linings of the pleural, peritoneal and pericardial cavities. The best-defined risk factor is exposure to carcinogenic mineral fibers (e.g., asbestos). Genomic studies have revealed that the most frequent genetic lesions in human MMe are mutations in tumor suppressor genes. Several genetically engineered mouse models have been generated by introducing the same genetic lesions found in human MMe. However, most of these models require specialized breeding facilities and long-term exposure of mice to asbestos for MMe development. Thus, an alternative model with high tumor penetrance without asbestos is urgently needed. We characterized an orthotopic model using MMe cells derived from Cdkn2a[+/-];Nf2[+/-] mice chronically injected with asbestos. These MMe cells were tumorigenic upon intraperitoneal injection. Moreover, MMe cells showed mixed chromosome and microsatellite instability, supporting the notion that genomic instability is relevant in MMe pathogenesis. In addition, microsatellite markers were detectable in the plasma of tumor-bearing mice, indicating a potential use for early cancer detection and monitoring the effects of interventions. This orthotopic model with rapid development of MMe without asbestos exposure represents genomic instability and specific molecular targets for therapeutic or preventive interventions to enable preclinical proof of concept for the intervention in an immunocompetent setting.},
}
@article {pmid35795882,
year = {2022},
author = {Tanaka, T and Asakura, S and Hisamatsu, K and Fujimoto, N},
title = {Thrombocytopenia as an Immune-Related Adverse Event in Malignant Pleural Mesothelioma: A Case Report.},
journal = {JTO clinical and research reports},
volume = {3},
number = {7},
pages = {100351},
pmid = {35795882},
issn = {2666-3643},
abstract = {A 69-year-old man presented with a pulmonary opacity at a regular medical check-up. He had been exposed to asbestos in a chemical fiber manufacturing setting. Result of positron emission tomography with computed tomography (CT) revealed fluorodeoxyglucose accumulations along the right pleura in areas with multiple nodules and irregular pleural thickening. On the basis of analysis of a CT-guided needle biopsy result, he had been diagnosed with having epithelioid malignant pleural mesothelioma. He received neoadjuvant chemotherapy, and subsequently, a pleurectomy and decortication. After 6 months, malignant pleural mesothelioma recurred with multiple tumors in the pleural cavity. Nivolumab was administered as salvage immunotherapy. A CT scan result revealed marked tumor reduction; however, his platelet count was low (8000/μL), and he was diagnosed with having nivolumab-induced immune thrombocytopenia. Oral prednisone and thrombopoietin receptor agonist were delivered, and the platelet count improved; therefore, a sustained cycle of nivolumab was resumed. This case revealed that nivolumab could be readministered for continued antitumor effects, with careful management of immune-related adverse events.},
}
@article {pmid35785199,
year = {2022},
author = {Kuryk, L and Rodella, G and Staniszewska, M and Pancer, KW and Wieczorek, M and Salmaso, S and Caliceti, P and Garofalo, M},
title = {Novel Insights Into Mesothelioma Therapy: Emerging Avenues and Future Prospects.},
journal = {Frontiers in oncology},
volume = {12},
number = {},
pages = {916839},
pmid = {35785199},
issn = {2234-943X},
abstract = {Malignant mesothelioma is a rare and aggressive cancer that develops in the thin layer surrounding the mesothelium and is mainly caused by asbestos exposure. Despite improvements in patient prognosis with conventional cancer treatments, such as surgery, chemotherapy, and radiotherapy, there are still no curative treatment modalities for advanced disease. In recent years, new therapeutic avenues have been explored. Improved understanding of the mechanisms underlying the dynamic tumor interaction with the immune system has led to the development of immunotherapeutic approaches. Numerous recent clinical trials have shown a desire to develop more effective treatments that can be used to fight against the disease. Immune checkpoint inhibitors, oncolytic adenoviruses, and their combination represent a promising strategy that can be used to synergistically overcome immunosuppression in the mesothelioma tumor microenvironment. This review provides a synthesized overview of the current state of knowledge on new therapeutic options for mesothelioma with a focus on the results of clinical trials conducted in the field.},
}
@article {pmid35778611,
year = {2022},
author = {Fennell, DA and Dulloo, S and Harber, J},
title = {Immunotherapy approaches for malignant pleural mesothelioma.},
journal = {Nature reviews. Clinical oncology},
volume = {19},
number = {9},
pages = {573-584},
pmid = {35778611},
issn = {1759-4782},
support = {21400/CRUK_/Cancer Research UK/United Kingdom ; },
mesh = {Humans ; Immunotherapy/methods ; *Lung Neoplasms/drug therapy ; *Mesothelioma/therapy ; *Mesothelioma, Malignant ; *Pleural Neoplasms/drug therapy/pathology ; Tumor Microenvironment ; *Vaccines/therapeutic use ; },
abstract = {Over the past decade, immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer. In mesothelioma, a rare cancer with a dismal prognosis generally caused by exposure to asbestos, treatment with single or dual ICIs results in robust improvements in overall survival over previous standard-of-care therapies, both in the first-line and relapsed disease settings. Predictive biological features that underpin response to ICIs remain poorly understood; however, insights into the immune microenvironment and genomic landscape of mesothelioma as well as into their association with response or acquired resistance to ICIs are emerging. Several studies of rational combinations involving ICIs with either another ICI or a different agent are ongoing, with emerging evidence of synergistic antitumour activity. Non-ICI-based immunotherapies, such as peptide-based vaccines and mesothelin-targeted chimeric antigen receptor T cells, have demonstrated promising efficacy. Moreover, results from pivotal trials of dendritic cell vaccines and viral cytokine delivery, among others, are eagerly awaited. In this Review, we comprehensively summarize the key steps in the development of immunotherapies for mesothelioma, focusing on strategies that have led to randomized clinical evaluation and emerging predictors of response. We then forecast the future treatment opportunities that could arise from ongoing research.},
}
@article {pmid35748766,
year = {2022},
author = {Locher, BN and Barresi, F and Kuhn, BK and Vrugt, B and Bopp, M and Dressel, H},
title = {Occupations and geographical distribution of mesothelioma in Switzerland 1989-2018 - record linkage of an asbestos-exposed population with the Swiss National Cohort.},
journal = {Swiss medical weekly},
volume = {152},
number = {},
pages = {w30164},
doi = {10.4414/smw.2022.w30164},
pmid = {35748766},
issn = {1424-3997},
mesh = {*Asbestos/toxicity ; Humans ; *Mesothelioma/epidemiology/etiology/pathology ; *Mesothelioma, Malignant ; *Occupational Exposure/adverse effects ; Occupations ; *Pleural Neoplasms/epidemiology/etiology/pathology ; Switzerland/epidemiology ; },
abstract = {OBJECTIVE: We investigated the possibility of linking the data of the Swiss Laboratory for Particle Analysis (Silag), a valuable but incomplete data source in the field of asbestos-related diseases, to the Swiss National Cohort (SNC). With the resulting comprehensive dataset, we intended to provide a source for further research in the field. We also conducted preliminary analyses of data focusing on occupations and regional distribution of malignant pleural mesothelioma cases.<br><br>METHODS: Data of asbestos-exposed individuals available from the Silag were anonymously linked with the SNC by means of deterministic record linkage. From this linkage, data on occupation classified according to the international standard classification of occupations (ISCO) as well as the canton of residence in Switzerland could be retrieved.<br><br>RESULTS: Of 838 eligible individuals from the Silag data, 788 (94.0%) could be linked to the SNC database, including 476 mesothelioma cases. In 340 cases of the latter, data on occupation and industries were available. Although the majority of them were blue-collar workers, a significant proportion (n = 44, 12.9%) had executive professions. The Canton of residence in 1990 was established in 430 of subjects with mesothelioma. A cluster could be identified in eastern Switzerland, especially in the canton of Glarus.<br><br>CONCLUSIONS: It was possible to link the datasets to a large extent thereby creating a data source for further research. Of note, the linkage provided data on occupation of a selection of mesothelioma cases in Switzerland.},
}
@article {pmid35743451,
year = {2022},
author = {Nagamatsu, Y and Sakyo, Y and Barroga, E and Koni, R and Natori, Y and Miyashita, M},
title = {Depression and Complicated Grief, and Associated Factors, of Bereaved Family Members of Patients Who Died of Malignant Pleural Mesothelioma in Japan.},
journal = {Journal of clinical medicine},
volume = {11},
number = {12},
pages = {},
pmid = {35743451},
issn = {2077-0383},
support = {16H05579, and 21H03241//Japan Society for the Promotion of Science/ ; 210901-01//Grants-in-Aid from the Ministry of Health, Labor and Welfare, Japan,/ ; },
abstract = {OBJECTIVES: we investigated the prevalence and associated factors of depression and complicated grief (CG) among bereaved family members of malignant pleural mesothelioma (MPM) patients in Japan.<br><br>METHODS: Bereaved family members of MPM patients (n = 72) were surveyed. The Japanese version of the Patient Health Questionnaire-9 (PHQ-9) and the Japanese version of the Brief Grief Questionnaire (BGQ) were used to assess depression and complicated grief (CG), respectively. Socio-economic factors, anger toward asbestos, care satisfaction, achievement of good death, and quality of end-of-life care were assessed in relation to depression and CG.<br><br>RESULTS: In the family members of MPM patients, the frequencies of depression and CG were 19.4% and 15.3%, respectively. The bereaved family members who were not compensated by the asbestos-related health-damage relief system (p = 0.018) and who felt the financial impacts of the patient's MPM on the family (p = 0.006) had a higher likelihood of depression. The bereaved family members who were not satisfied with the care given when the patient became critical (p = 0.034), who were not compensated by the asbestos-related health-damage relief system (p = 0.020), who felt the financial impact of the patient's MPM on the family (p = 0.016), and whose deceased relative underwent surgery (p = 0.030) had a higher likelihood of CG.<br><br>CONCLUSIONS: For bereaved family members of MPM patients, routine screening for depression and CG and the provision of grief care are suggested. In addition, for family members of MPM patients, financial support, including the promotion of the asbestos-related health-damage relief system, and improved care for patients who undergo surgery and when patients become critical, are recommended.},
}
@article {pmid35743417,
year = {2022},
author = {Bellini, A and Mazzarra, S and Sterrantino, S and Argnani, D and Stella, F},
title = {Second Surgery for Recurrent Malignant Pleural Mesothelioma after Multimodality Treatment: A Systematic Review.},
journal = {Journal of clinical medicine},
volume = {11},
number = {12},
pages = {},
pmid = {35743417},
issn = {2077-0383},
abstract = {Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related tumour with poor prognosis. To date, a multimodality treatment, including chemotherapy and surgery, with or without radiotherapy, is the gold standard therapy for selected patients with epithelioid and early-stage MPM. In this setting, the goal of surgery is to achieve the macroscopic complete resection, obtained by either extrapleural pneumonectomy or pleurectomy/decortication. Failure, in local and/or distant sites, is one of the major concerns; in fact, there has been no established treatment for the recurrence of MPM after the multimodal approach, and the role of surgery in this context is still controversial. By using electronic databases, studies that included recurrent MPM patients who underwent a second surgery were identified. The endpoints included were: a pattern of recurrence, post-recurrence survival (PRS), and the type of second surgery. When available, factors predicting better PRS and perioperative mortality and morbidity were collected. This systematic review offers an overview of the results that are currently obtained in patients undergoing a second surgery for relapsed MPM, with the aim to provide a comprehensive view on this subject that explores if a second surgery leads to an improvement in survival.},
}
@article {pmid35741021,
year = {2022},
author = {Pellavio, G and Martinotti, S and Patrone, M and Ranzato, E and Laforenza, U},
title = {Aquaporin-6 May Increase the Resistance to Oxidative Stress of Malignant Pleural Mesothelioma Cells.},
journal = {Cells},
volume = {11},
number = {12},
pages = {},
pmid = {35741021},
issn = {2073-4409},
mesh = {Aquaporin 6/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; *Mesothelioma/diagnosis/drug therapy/genetics ; *Mesothelioma, Malignant ; Oxidative Stress ; },
abstract = {Malignant pleural mesothelioma (MPM) is an aggressive cancer of the pleural surface and is associated with previous asbestos exposure. The chemotherapy drug is one of the main treatments, but the median survival ranges from 8 to 14 months from diagnosis. The redox homeostasis of tumor cells should be carefully considered since elevated levels of ROS favor cancer cell progression (proliferation and migration), while a further elevation leads to ferroptosis. This study aims to analyze the functioning/role of aquaporins (AQPs) as a hydrogen peroxide (H2O2) channel in epithelial and biphasic MPM cell lines, as well as their possible involvement in chemotherapy drug resistance. Results show that AQP-3, -5, -6, -9, and -11 were expressed at mRNA and protein levels. AQP-6 was localized in the plasma membrane and intracellular structures. Compared to normal mesothelial cells, the water permeability of mesothelioma cells is not reduced by exogenous oxidative stress, but it is considerably increased by heat stress, making these cells resistant to ferroptosis. Functional experiments performed in mesothelioma cells silenced for aquaporin-6 revealed that it is responsible, at least in part, for the increase in H2O2 efflux caused by heat stress. Moreover, mesothelioma cells knocked down for AQP-6 showed a reduced proliferation compared to mock cells. Current findings suggest the major role of AQP-6 in providing mesothelioma cells with the ability to resist oxidative stress that underlies their resistance to chemotherapy drugs.},
}
@article {pmid35723508,
year = {2022},
author = {Lee, JT and Mittal, DL and Warby, A and Kao, S and Dhillon, HM and Vardy, JL},
title = {Dying of mesothelioma: A qualitative exploration of caregiver experiences.},
journal = {European journal of cancer care},
volume = {31},
number = {5},
pages = {e13627},
pmid = {35723508},
issn = {1365-2354},
support = {//Dust Diseases Board NSW/ ; },
mesh = {Adaptation, Psychological ; *Bereavement ; Caregivers ; Humans ; *Mesothelioma/therapy ; Palliative Care ; Qualitative Research ; },
abstract = {OBJECTIVE: To explore the experience of family caregivers of people with mesothelioma with focus on end-of-life issues.<br><br>METHODS: A qualitative sub-study using semi-structured interviews and thematic analysis.<br><br>RESULTS: Fourteen caregivers were interviewed; 11 were bereaved. The overarching theme was the impact of patients' diagnosis, treatment and death on caregivers and families. Three main themes were identified: (i) information provision and decision-making; (ii) grief and bereavement; and (iii) involvement and timing of palliative care. Caregivers initially had minimal knowledge of mesothelioma and wanted more information. Prognostic uncertainty caused distress. Grief and bereavement sub-themes were (i) coping and personal priorities; (ii) reflections on dying; and (iii) reflections on care. Caregivers highlighted the importance of creating meaningful events, having hope, 'doing something' and support from family and external sources. Reflections on dying contrasted regret after a 'bad', often unexpected death, with 'good' deaths. Care was made difficult by challenges navigating the health system and perceived gaps. Caregivers reported late referral to palliative care.<br><br>CONCLUSION: Lack of information caused challenges for caregivers. Grief and bereavement outcomes varied and may have been adversely impacted by lack of engagement with palliative care. Integrated care with lung cancer coordinators and improved palliative care access may reduce caregiver burden.},
}
@article {pmid35717324,
year = {2022},
author = {Migliore, E and Consonni, D and Peters, S and Vermeulen, RCH and Kromhout, H and Baldassarre, A and Cavone, D and Chellini, E and Magnani, C and Mensi, C and Merler, E and Musti, M and Marinaccio, A and Mirabelli, D},
title = {Pleural mesothelioma risk by industry and occupation: results from the Multicentre Italian Study on the Etiology of Mesothelioma (MISEM).},
journal = {Environmental health : a global access science source},
volume = {21},
number = {1},
pages = {60},
pmid = {35717324},
issn = {1476-069X},
mesh = {*Asbestos ; Case-Control Studies ; Female ; Humans ; Italy/epidemiology ; Male ; *Mesothelioma/epidemiology/etiology ; *Mesothelioma, Malignant ; *Occupational Diseases/epidemiology/etiology ; *Occupational Exposure/adverse effects ; Occupations ; *Pleural Neoplasms/epidemiology/etiology ; },
abstract = {BACKGROUND: The Italian mesothelioma registry (ReNaM) estimates mesothelioma incidence and addresses its etiology by assessing cases' exposures but cannot provide relative risk estimates.<br><br>OBJECTIVES: i) To estimate pleural mesothelioma relative risk by industry and occupation and by ReNaM categories of asbestos exposure; and ii) to provide quantitative estimates of the exposure-response relationship.<br><br>METHODS: A population-based mesothelioma case-control study was conducted in 2012-2014 in five Italian regions. Cases and age and gender frequency-matched controls were interviewed using a standard ReNaM questionnaire. Experts coded work histories according to international standard classifications of industries/occupations and assigned asbestos exposure according to ReNaM categories. Job codes were further linked to SYN-JEM, a quantitative job-exposure matrix. Cumulative exposure (CE, f/mL-years) was computed by summing individual exposures over lifetime work history. Unconditional logistic regression analyses adjusted by gender, centre and age were fitted to calculate odds ratios (OR) and 95% confidence intervals (CI).<br><br>RESULTS: Among men we observed increased risks of mesothelioma in many industries and associated occupations, including: asbestos-cement (OR&#x2009;=&#x2009;3.43), manufacture of railroad equipment (OR&#x2009;=&#x2009;8.07), shipbuilding and repairing (OR&#x2009;=&#x2009;2.34), iron and steel mills (OR&#x2009;=&#x2009;2.15), and construction (OR&#x2009;=&#x2009;1.94). ORs by ReNaM exposure categories were as follows: definite/probable occupational exposure (OR&#x2009;=&#x2009;15.8, men; OR&#x2009;=&#x2009;8.80, women), possible occupational (OR&#x2009;=&#x2009;2.82, men; OR&#x2009;=&#x2009;3.70, women), sharing home with an exposed worker (OR&#x2009;=&#x2009;2.55, men; OR&#x2009;=&#x2009;10.3, women), residential (OR&#x2009;=&#x2009;2.14, men; OR&#x2009;=&#x2009;3.24, women). Based on SYN-JEM, mesothelioma risk increased by almost 30% per f/mL-year (OR&#x2009;=&#x2009;1.28, CI 1.16-1.42).<br><br>CONCLUSIONS: Out study involved five regions with historically different types and levels of industrial development, encompassing one third of the Italian population and half of Italian mesothelioma cases. As expected, we found increased pleural mesothelioma risk in the asbestos industry and in trades with large consumption of asbestos materials. Clear associations were found using both qualitative (ReNaM classifications) and quantitative estimates (using SYN-JEM) of past asbestos exposure, with clear evidence of an exposure-response relationship.},
}
@article {pmid35713639,
year = {2022},
author = {Malpica, A and Euscher, ED and Marques-Piubelli, ML and Miranda, RN and Raghav, KP and Fournier, KF and Ramalingam, P},
title = {Localized Malignant Peritoneal Mesothelioma (LMPeM) in Women: A Clinicopathologic Study of 18 Cases.},
journal = {The American journal of surgical pathology},
volume = {46},
number = {10},
pages = {1352-1363},
doi = {10.1097/PAS.0000000000001924},
pmid = {35713639},
issn = {1532-0979},
mesh = {Adult ; Aged ; *Asbestos/adverse effects ; Female ; Homozygote ; Humans ; *Mesothelioma ; *Mesothelioma, Malignant ; Middle Aged ; MutS Homolog 2 Protein ; *Peritoneal Neoplasms/genetics ; Sequence Deletion ; },
abstract = {Localized malignant peritoneal mesothelioma is a rare tumor with limited information in the literature. In this study, we present our experience with 18 cases seen in our hospital over a period of 43 years (1978 to 2021). Patients' median age was 55 years (y) (range: 33 to 79 y) and most of them were Caucasians. Patients presented with abdominal pain (11), ascites and right leg swelling (1), abdominal mass (1), and as incidental finding (1). Thirty percent of patients reported asbestos exposure, and all patients with available information had family history of tumors; a third had personal history of tumors. Seventy-seven percent had some form of abdominopelvic surgery and/or inflammatory process. Most cases had microscopic features typically seen in malignant mesothelioma; however, some cases had confounding features such as signet-ring cells, spindle cells, clear cell changes, and adenomatoid tumor-like appearance. BAP-1 by immunohistochemistry was lost in 1/3 cases. Only 1 patient underwent genetic testing and had an MSH2 germline mutation. Homozygous deletion of CDKN2A by FISH was not found in 1 tested case, although next-generation sequencing identified a CDKN2A pathogenic mutation. 16/18 (88%) had surgical treatment, and some also received adjuvant chemotherapy. The mean overall survival (OS) of our patients was 80.4 months (95% confidence interval: 54.3-106.52); the 3-year OS was 79%, while the 5-year OS was 52.6%. Fifty-three percent of patients had recurrences and 20% had tumor progression. Although the limited sample precludes definitive conclusions, small tumor size, low-grade cytology, and low mitotic index appeared to be associated with an indolent behavior.},
}
@article {pmid35703172,
year = {2022},
author = {Bernstein, DM},
title = {The health effects of short fiber chrysotile and amphibole asbestos.},
journal = {Critical reviews in toxicology},
volume = {52},
number = {2},
pages = {89-112},
doi = {10.1080/10408444.2022.2056430},
pmid = {35703172},
issn = {1547-6898},
mesh = {*Asbestos ; Asbestos, Amphibole/toxicity ; Asbestos, Serpentine/toxicity ; Humans ; Lung ; *Lung Neoplasms/epidemiology ; *Mesothelioma/epidemiology ; },
abstract = {The potential toxic effects of short chrysotile and amphibole asbestos fibers with lengths <5 to ∼10 µm have been debated over the years. This stems from the large database of epidemiology, toxicology, and in-vitro studies, each of which often provides different information in understanding and differentiating the effects of short fibers. The epidemiology studies in which the cancer potency estimates were based upon relatively high exposure concentrations provide a conservative assessment that shorter fibers would have little if any effect, especially under controlled exposure or environmental conditions that may occur today. The QSAR models have shown that fiber aspect ratio and Mg content are excellent predictors of cancer potency and that short fibers/particles of amphibole would have no effect. The studies of motor vehicle mechanics and in particular workers who serviced chrysotile containing brakes with the majority of the fibers being short provides evidence that motor vehicle mechanics, including workers who were engaged in brake repair, are not at an increased risk of mesothelioma. Several inhalation toxicology studies clearly differentiated that short chrysotile and amphibole asbestos fibers did not produce a significant carcinogenic effect in the lung or pleural cavity. Because of dosing and lack of sensitivity to biosolubility, in vitro studies can be difficult to interpret; however, a number have differentiated short chrysotile and amphibole asbestos fibers from long fibers. Integral to understanding the importance of fiber length in determining possible health effects is an understanding of the biological and physiological function of the respiratory system. Short asbestos fibers, like innocuous dust, can be cleared through the tracheobronchial ciliated mucous transport, phagocytized by macrophages and cleared via the bronchial tree, and can also be removed through the lymphatic system. While the first two methods can remove them from the lung, with lymphatic transport through one-way valves, fibers are removed from the active area of the lung where the fiber-related disease has been shown to develop and can accumulate in lymphatic sumps and lymph nodes. While short asbestos fibers are present in most occupational or environmental exposures, the large body of studies strongly supports that they do not contribute to the health effects of asbestos exposure.},
}
@article {pmid35670855,
year = {2022},
author = {Napoli, F and Rapa, I and Izzo, S and Rigutto, A and Libener, R and Riganti, C and Bironzo, P and Taulli, R and Papotti, M and Volante, M and Scagliotti, G and Righi, L},
title = {Correction to: Micro-RNA-215 and -375 regulate thymidylate synthase protein expression in pleural mesothelioma and mediate epithelial to mesenchymal transition.},
journal = {Virchows Archiv : an international journal of pathology},
volume = {481},
number = {2},
pages = {331},
doi = {10.1007/s00428-022-03355-y},
pmid = {35670855},
issn = {1432-2307},
}
@article {pmid35665561,
year = {2022},
author = {Dermawan, JK and Torrence, D and Lee, CH and Villafania, L and Mullaney, KA and DiNapoli, S and Sukhadia, P and Benayed, R and Borsu, L and Agaram, NP and Nash, GM and Dickson, BC and Benhamida, J and Antonescu, CR},
title = {EWSR1::YY1 fusion positive peritoneal epithelioid mesothelioma harbors mesothelioma epigenetic signature: Report of 3 cases in support of an emerging entity.},
journal = {Genes, chromosomes &amp; cancer},
volume = {61},
number = {10},
pages = {592-602},
pmid = {35665561},
issn = {1098-2264},
support = {P30 CA008748/CA/NCI NIH HHS/United States ; P50 CA140146/CA/NCI NIH HHS/United States ; P50 CA217694/CA/NCI NIH HHS/United States ; },
mesh = {Biomarkers, Tumor/genetics ; Epigenesis, Genetic ; Epigenomics ; Female ; Humans ; Male ; *Mesothelioma/genetics ; *Mesothelioma, Malignant ; Middle Aged ; *Peritoneal Neoplasms/genetics/pathology ; RNA-Binding Protein EWS/genetics ; YY1 Transcription Factor/genetics/metabolism ; Young Adult ; },
abstract = {Mesothelioma is a rare, aggressive malignant neoplasm of mesothelial origin. A small subset of peritoneal mesothelioma is driven by recurrent gene fusions, mostly EWSR1/FUS::ATF1 fusions, with predilection for young adults. To date, only two cases of mesothelioma harboring EWSR1::YY1 fusions have been described. We present three additional cases of EWSR1::YY1-fused peritoneal mesotheliomas, two localized and one diffuse, all occurring in the peritoneum of middle-aged adults (2 females and 1 male), and discovered incidentally by imaging or during surgery performed for unrelated reasons. None presented with symptoms or had a known history of asbestos exposure. All three cases were cellular epithelioid neoplasms with heterogeneous architectural patterns comprising mostly solid nests and sheets with variably papillary and trabecular areas against collagenous stroma. Cytologically, the cells were monomorphic, polygonal, epithelioid cells with dense eosinophilic cytoplasm and centrally located nuclei. Overt mitotic activity or tumor necrosis was absent. All cases showed strong diffuse immunoreactivity for pancytokeratin, CK7, and nuclear WT1, patchy to negative calretinin, retained BAP1 expression, and were negative for Ber-EP4 and MOC31. RNA-sequencing confirmed in-frame gene fusion transcripts involving EWSR1 exon 7/8 and YY1 exon 2/3. By unsupervised clustering analysis, the methylation profiles of EWSR1::YY1-fused mesotheliomas clustered similarly with EWSR1/FUS::ATF1-fused mesotheliomas and conventional mesotheliomas, suggesting a mesothelioma epigenetic signature. All three patients underwent surgical resection or cytoreductive surgery of th