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ESP: PubMed Auto Bibliography 03 Jul 2022 at 01:43 Created:
Gregor Mendel
In 1865, Gregor Mendel reported the results of his experiments with peas and in so doing laid the foundations of what has become the modern science of genetics. There are few examples of entire fields having been so clearly founded upon the works of one man.
Created with PubMed® Query: mendel[title] AND (gregor OR brno OR versuche OR darwin OR "father of genetics") NOT "James Ross" NOT Antarctic NOT pmcbook NOT ispreviousversion
Citations The Papers (from PubMed®)
RevDate: 2022-05-04
Gregor Mendel and the concepts of dominance and recessiveness.
Nature reviews. Genetics [Epub ahead of print].
Additional Links: PMID-35508637
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@article {pmid35508637,
year = {2022},
author = {Zschocke, J and Byers, PH and Wilkie, AOM},
title = {Gregor Mendel and the concepts of dominance and recessiveness.},
journal = {Nature reviews. Genetics},
volume = {},
number = {},
pages = {},
pmid = {35508637},
issn = {1471-0064},
}
RevDate: 2022-04-20
Celebrating Mendel, McClintock, and Darlington: On end-to-end chromosome fusions and nested chromosome fusions.
The Plant cell pii:6571155 [Epub ahead of print].
The evolution of eukaryotic genomes is accompanied by fluctuations in chromosome number, reflecting cycles of chromosome number increase (polyploidy, centric fissions) and decrease (chromosome fusions). Although all chromosome fusions result from DNA recombination between two or more non-homologous chromosomes, several mechanisms of descending dysploidy are exploited by eukaryotes to reduce their chromosome number. Genome sequencing and comparative genomics have accelerated the identification of inter-genome chromosome collinearity and gross chromosomal rearrangements and have shown that end-to-end chromosome fusions (EEFs) and nested chromosome fusions (NCFs) may have played a more important role in the evolution of eukaryotic karyotypes than previously thought. The present review aims to summarize the limited knowledge on the origin, frequency, and evolutionary implications of EEF and NCF events in eukaryotes and especially in land plants. The interactions between non-homologous chromosomes in interphase nuclei and chromosome (mis)pairing during meiosis are examined for their potential importance in the origin of EEFs and NCFs. The remaining open questions that need to be addressed are discussed.
Additional Links: PMID-35441689
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@article {pmid35441689,
year = {2022},
author = {Lysak, MA},
title = {Celebrating Mendel, McClintock, and Darlington: On end-to-end chromosome fusions and nested chromosome fusions.},
journal = {The Plant cell},
volume = {},
number = {},
pages = {},
doi = {10.1093/plcell/koac116},
pmid = {35441689},
issn = {1532-298X},
abstract = {The evolution of eukaryotic genomes is accompanied by fluctuations in chromosome number, reflecting cycles of chromosome number increase (polyploidy, centric fissions) and decrease (chromosome fusions). Although all chromosome fusions result from DNA recombination between two or more non-homologous chromosomes, several mechanisms of descending dysploidy are exploited by eukaryotes to reduce their chromosome number. Genome sequencing and comparative genomics have accelerated the identification of inter-genome chromosome collinearity and gross chromosomal rearrangements and have shown that end-to-end chromosome fusions (EEFs) and nested chromosome fusions (NCFs) may have played a more important role in the evolution of eukaryotic karyotypes than previously thought. The present review aims to summarize the limited knowledge on the origin, frequency, and evolutionary implications of EEF and NCF events in eukaryotes and especially in land plants. The interactions between non-homologous chromosomes in interphase nuclei and chromosome (mis)pairing during meiosis are examined for their potential importance in the origin of EEFs and NCFs. The remaining open questions that need to be addressed are discussed.},
}
RevDate: 2022-04-13
Demystifying the mythical Mendel: a biographical review.
Heredity [Epub ahead of print].
Gregor Mendel is widely recognised as the founder of genetics. His experiments led him to devise an enduring theory, often distilled into what are now known as the principles of segregation and independent assortment. Although he clearly articulated these principles, his theory is considerably richer, encompassing the nature of fertilisation, the role of hybridisation in evolution, and aspects often considered as exceptions or extensions, such as pleiotropy, incomplete dominance, and epistasis. In an admirable attempt to formulate a more expansive theory, he researched hybridisation in at least twenty plant genera, intentionally choosing some species whose inheritance he knew would deviate from the patterns he observed in the garden pea (Pisum sativum). Regrettably, he published the results of only a few of these additional experiments; evidence of them is largely confined to letters he wrote to Carl von Nägeli. Because most original documentation is lost or destroyed, scholars have attempted to reconstruct his history and achievements from fragmentary evidence, a situation that has led to unfortunate omissions, errors, and speculations. These range from historical uncertainties, such as what motivated his experiments, to unfounded suppositions regarding his discoveries, including assertions that he never articulated the principles ascribed to him, staunchly opposed Darwinism, fictitiously recounted experiments, and falsified data to better accord with his theory. In this review, I have integrated historical and scientific evidence within a biographical framework to dispel misconceptions and provide a clearer and more complete view of who Mendel was and what he accomplished.
Additional Links: PMID-35414696
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Citation:
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@article {pmid35414696,
year = {2022},
author = {Fairbanks, DJ},
title = {Demystifying the mythical Mendel: a biographical review.},
journal = {Heredity},
volume = {},
number = {},
pages = {},
pmid = {35414696},
issn = {1365-2540},
abstract = {Gregor Mendel is widely recognised as the founder of genetics. His experiments led him to devise an enduring theory, often distilled into what are now known as the principles of segregation and independent assortment. Although he clearly articulated these principles, his theory is considerably richer, encompassing the nature of fertilisation, the role of hybridisation in evolution, and aspects often considered as exceptions or extensions, such as pleiotropy, incomplete dominance, and epistasis. In an admirable attempt to formulate a more expansive theory, he researched hybridisation in at least twenty plant genera, intentionally choosing some species whose inheritance he knew would deviate from the patterns he observed in the garden pea (Pisum sativum). Regrettably, he published the results of only a few of these additional experiments; evidence of them is largely confined to letters he wrote to Carl von Nägeli. Because most original documentation is lost or destroyed, scholars have attempted to reconstruct his history and achievements from fragmentary evidence, a situation that has led to unfortunate omissions, errors, and speculations. These range from historical uncertainties, such as what motivated his experiments, to unfounded suppositions regarding his discoveries, including assertions that he never articulated the principles ascribed to him, staunchly opposed Darwinism, fictitiously recounted experiments, and falsified data to better accord with his theory. In this review, I have integrated historical and scientific evidence within a biographical framework to dispel misconceptions and provide a clearer and more complete view of who Mendel was and what he accomplished.},
}
RevDate: 2022-03-21
Mendel the fraud? A social history of truth in genetics.
Studies in history and philosophy of science, 93:39-46 pii:S0039-3681(21)00212-0 [Epub ahead of print].
Two things about Gregor Mendel are common knowledge: first, that he was the "monk in the garden" whose experiments with peas in mid-nineteenth-century Moravia became the starting point for genetics; second, that, despite that exalted status, there is something fishy, maybe even fraudulent, about the data that Mendel reported. Although the notion that Mendel's numbers were, in statistical terms, too good to be true was well understood almost immediately after the famous "rediscovery" of his work in 1900, the problem became widely discussed and agonized over only from the 1960s, for reasons having as much to do with Cold War geopolitics as with traditional concerns about the objectivity of science. Appreciating the historical origins of the problem as we have inherited it can be a helpful step in shifting the discussion in more productive directions, scientific as well as historiographic.
Additional Links: PMID-35313209
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@article {pmid35313209,
year = {2022},
author = {Radick, G},
title = {Mendel the fraud? A social history of truth in genetics.},
journal = {Studies in history and philosophy of science},
volume = {93},
number = {},
pages = {39-46},
doi = {10.1016/j.shpsa.2021.12.012},
pmid = {35313209},
issn = {0039-3681},
abstract = {Two things about Gregor Mendel are common knowledge: first, that he was the "monk in the garden" whose experiments with peas in mid-nineteenth-century Moravia became the starting point for genetics; second, that, despite that exalted status, there is something fishy, maybe even fraudulent, about the data that Mendel reported. Although the notion that Mendel's numbers were, in statistical terms, too good to be true was well understood almost immediately after the famous "rediscovery" of his work in 1900, the problem became widely discussed and agonized over only from the 1960s, for reasons having as much to do with Cold War geopolitics as with traditional concerns about the objectivity of science. Appreciating the historical origins of the problem as we have inherited it can be a helpful step in shifting the discussion in more productive directions, scientific as well as historiographic.},
}
RevDate: 2022-03-03
Which field of research would Gregor Mendel choose in the 21st century?.
The Plant cell pii:6539763 [Epub ahead of print].
Gregor Mendel's work on segregation of traits in plants established the basic methodology and rules of genetics. The interruption of Mendel's research activities in 1870 impeded the immediate recognition of the value of his work until the dawn of the 20th century. Only then were his founding laws of genetics validated, propelling the development of biological research towards the birth of molecular biology in the second half of the 20th century. While molecular plant genetics can be viewed as the spiritual heir of Mendel's research, one might wonder whether in the 21st century Gregor Mendel would prefer to practice scientific approaches other than molecular genetics such as population genetics, comparative genomics, or the emerging field of evo-chromo. In this perspective I review aspects of these fields that might have attracted or perplexed a 21st century Mendel.
Additional Links: PMID-35238371
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@article {pmid35238371,
year = {2022},
author = {Berger, F},
title = {Which field of research would Gregor Mendel choose in the 21st century?.},
journal = {The Plant cell},
volume = {},
number = {},
pages = {},
doi = {10.1093/plcell/koac072},
pmid = {35238371},
issn = {1532-298X},
abstract = {Gregor Mendel's work on segregation of traits in plants established the basic methodology and rules of genetics. The interruption of Mendel's research activities in 1870 impeded the immediate recognition of the value of his work until the dawn of the 20th century. Only then were his founding laws of genetics validated, propelling the development of biological research towards the birth of molecular biology in the second half of the 20th century. While molecular plant genetics can be viewed as the spiritual heir of Mendel's research, one might wonder whether in the 21st century Gregor Mendel would prefer to practice scientific approaches other than molecular genetics such as population genetics, comparative genomics, or the emerging field of evo-chromo. In this perspective I review aspects of these fields that might have attracted or perplexed a 21st century Mendel.},
}
RevDate: 2021-10-22
Principles and biological concepts of heredity before Mendel.
Biology direct, 16(1):19.
The knowledge of the history of a subject stimulates understanding. As we study how other people have made scientific breakthroughs, we develop the breadth of imagination that would inspire us to make new discoveries of our own. This perspective certainly applies to the teaching of genetics as hallmarked by the pea experiments of Mendel. Common questions students have in reading Mendel's paper for the first time is how it compares to other botanical, agricultural, and biological texts from the early and mid-nineteenth centuries; and, more precisely, how Mendel's approach to, and terminology for debating, topics of heredity compare to those of his contemporaries? Unfortunately, textbooks are often unavailing in answering such questions. It is very common to find an introduction about heredity in genetic textbooks covering Mendel without mentions of preceding breeding experiments carried out in his alma mater. This does not help students to understand how Mendel came to ask the questions he did, why he did, or why he planned his pea studies the way he did. Furthermore, the standard textbook "sketch" of genetics does not allow students to consider how discoveries could have been framed and inspired so differently in various parts of the world within a single historical time. In our review we provide an extended overview bridging this gap by showing how different streams of ideas lead to the eventual foundation of particulate inheritance as a scientific discipline. We close our narrative with investigations on the origins of animal and plant breeding in Central Europe prior to Mendel in Kőszeg and Brno, where vigorous debates touched on basic issues of heredity from the early eighteenth-century eventually reaching a pinnacle coining the basic questions: What is inherited and how is it passed on from one generation to another?
Additional Links: PMID-34674746
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Citation:
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@article {pmid34674746,
year = {2021},
author = {Poczai, P and Santiago-Blay, JA},
title = {Principles and biological concepts of heredity before Mendel.},
journal = {Biology direct},
volume = {16},
number = {1},
pages = {19},
pmid = {34674746},
issn = {1745-6150},
abstract = {The knowledge of the history of a subject stimulates understanding. As we study how other people have made scientific breakthroughs, we develop the breadth of imagination that would inspire us to make new discoveries of our own. This perspective certainly applies to the teaching of genetics as hallmarked by the pea experiments of Mendel. Common questions students have in reading Mendel's paper for the first time is how it compares to other botanical, agricultural, and biological texts from the early and mid-nineteenth centuries; and, more precisely, how Mendel's approach to, and terminology for debating, topics of heredity compare to those of his contemporaries? Unfortunately, textbooks are often unavailing in answering such questions. It is very common to find an introduction about heredity in genetic textbooks covering Mendel without mentions of preceding breeding experiments carried out in his alma mater. This does not help students to understand how Mendel came to ask the questions he did, why he did, or why he planned his pea studies the way he did. Furthermore, the standard textbook "sketch" of genetics does not allow students to consider how discoveries could have been framed and inspired so differently in various parts of the world within a single historical time. In our review we provide an extended overview bridging this gap by showing how different streams of ideas lead to the eventual foundation of particulate inheritance as a scientific discipline. We close our narrative with investigations on the origins of animal and plant breeding in Central Europe prior to Mendel in Kőszeg and Brno, where vigorous debates touched on basic issues of heredity from the early eighteenth-century eventually reaching a pinnacle coining the basic questions: What is inherited and how is it passed on from one generation to another?},
}
RevDate: 2021-09-08
Victor Almon McKusick: In the footsteps of Mendel and Osler.
American journal of medical genetics. Part A [Epub ahead of print].
Victor Almon McKusick (VAM) is widely recognized as the father of the field of medical genetics. He established one of the first medical genetics clinics in the United States at Johns Hopkins in 1957 and developed a robust training program with the tripartite mission of education, research, and clinical care. Thousands of clinicians and scientists were educated over the years through the Short Course in Medical and Molecular Genetics, which VAM founded with Dr. Thomas Roderick in 1960. His Online Mendelian Inheritance in Man (OMIM), a catalog of human genes and genetic disorders, serves as the authoritative reference for geneticists around the globe. Throughout his career he was an advocate for mapping the human genome. He collaborated with Dr. Frank Ruddle in founding the International Human Gene Mapping Workshops in the early 70's and was an avid proponent of the Human Genome Project. He was the founding President of the Human Genome Organization and a founding editor of the journal Genomics. His prodigious contributions to the field of medical genetics were recognized by multiple honors, culminating with the Japan Prize in 2008.
Additional Links: PMID-34463023
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@article {pmid34463023,
year = {2021},
author = {Francomano, CA},
title = {Victor Almon McKusick: In the footsteps of Mendel and Osler.},
journal = {American journal of medical genetics. Part A},
volume = {},
number = {},
pages = {},
doi = {10.1002/ajmg.a.62451},
pmid = {34463023},
issn = {1552-4833},
abstract = {Victor Almon McKusick (VAM) is widely recognized as the father of the field of medical genetics. He established one of the first medical genetics clinics in the United States at Johns Hopkins in 1957 and developed a robust training program with the tripartite mission of education, research, and clinical care. Thousands of clinicians and scientists were educated over the years through the Short Course in Medical and Molecular Genetics, which VAM founded with Dr. Thomas Roderick in 1960. His Online Mendelian Inheritance in Man (OMIM), a catalog of human genes and genetic disorders, serves as the authoritative reference for geneticists around the globe. Throughout his career he was an advocate for mapping the human genome. He collaborated with Dr. Frank Ruddle in founding the International Human Gene Mapping Workshops in the early 70's and was an avid proponent of the Human Genome Project. He was the founding President of the Human Genome Organization and a founding editor of the journal Genomics. His prodigious contributions to the field of medical genetics were recognized by multiple honors, culminating with the Japan Prize in 2008.},
}
RevDate: 2021-08-02
CmpDate: 2021-08-02
Darwin meets Mendel in the reproductive medicine field: Homo sapiens 2.0 is inevitable.
Fertility and sterility, 115(4):850-851.
Additional Links: PMID-33642062
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@article {pmid33642062,
year = {2021},
author = {O'Brien, JE and Adashi, EY and Simon, C},
title = {Darwin meets Mendel in the reproductive medicine field: Homo sapiens 2.0 is inevitable.},
journal = {Fertility and sterility},
volume = {115},
number = {4},
pages = {850-851},
doi = {10.1016/j.fertnstert.2021.01.047},
pmid = {33642062},
issn = {1556-5653},
mesh = {*Biological Evolution ; Genetic Code/genetics ; Humans ; Infertility/diagnosis/genetics ; Preimplantation Diagnosis/methods/*trends ; Reproduction/*genetics ; Reproductive Medicine/methods/*trends ; Selection, Genetic/*genetics ; },
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
*Biological Evolution
Genetic Code/genetics
Humans
Infertility/diagnosis/genetics
Preimplantation Diagnosis/methods/*trends
Reproduction/*genetics
Reproductive Medicine/methods/*trends
Selection, Genetic/*genetics
RevDate: 2020-08-24
CmpDate: 2020-08-24
[Was Gregor Mendel subjected to chores before becoming a monk in 1843?].
Medecine sciences : M/S, 36(1):63-68.
Our knowledge of the young Mendel's life prior to his admission to the monastery comes essentially from the curriculum vitae submitted in 1850. His first biographer Hugo Iltis used this document as a sort of autobiography, although the document contained various voluntary omissions and inaccuracies. We have sought the reasons for these and in so doing have discovered why Mendel's entry into religion had become ineluctable.
Additional Links: PMID-32014100
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@article {pmid32014100,
year = {2020},
author = {Nivet, C},
title = {[Was Gregor Mendel subjected to chores before becoming a monk in 1843?].},
journal = {Medecine sciences : M/S},
volume = {36},
number = {1},
pages = {63-68},
doi = {10.1051/medsci/2019265},
pmid = {32014100},
issn = {1958-5381},
mesh = {Czech Republic ; Faculty/education/*history ; History, 19th Century ; Humans ; Monks/*history ; Philosophy/history ; Social Class/*history ; Taxes ; Teacher Training/history ; *Theology/education/history ; *Work/economics/history ; },
abstract = {Our knowledge of the young Mendel's life prior to his admission to the monastery comes essentially from the curriculum vitae submitted in 1850. His first biographer Hugo Iltis used this document as a sort of autobiography, although the document contained various voluntary omissions and inaccuracies. We have sought the reasons for these and in so doing have discovered why Mendel's entry into religion had become ineluctable.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Czech Republic
Faculty/education/*history
History, 19th Century
Humans
Monks/*history
Philosophy/history
Social Class/*history
Taxes
Teacher Training/history
*Theology/education/history
*Work/economics/history
RevDate: 2021-07-31
CmpDate: 2021-05-19
Mendel and Darwin: untangling a persistent enigma.
Heredity, 124(2):263-273.
Mendel and Darwin were contemporaries, with much overlap in their scientifically productive years. Available evidence shows that Mendel knew much about Darwin, whereas Darwin knew nothing of Mendel. Because of the fragmentary nature of this evidence, published inferences regarding Mendel's views on Darwinian evolution are contradictory and enigmatic, with claims ranging from enthusiastic acceptance to outright rejection. The objective of this review is to examine evidence from Mendel's published and private writings on evolution and Darwin, and the influence of the scientific environment in which he was immersed. Much of this evidence lies in Mendel's handwritten annotations in his copies of Darwin's books, which this review scrutinises in detail. Darwin's writings directly influenced Mendel's classic 1866 paper, and his letters to Nägeli. He commended and criticised Darwin on specific issues pertinent to his research, including the provisional hypothesis of pangenesis, the role of pollen in fertilisation, and the influence of "conditions of life" on heritable variation. In his final letter to Nägeli, Mendel proposed a Darwinian scenario for natural selection using the same German term for "struggle for existence" as in his copies of Darwin's books. His published and private scientific writings are entirely objective, devoid of polemics or religious allusions, and address evolutionary questions in a manner consistent with that of his scientific contemporaries. The image that emerges of Mendel is of a meticulous scientist who accepted the tenets of Darwinian evolution, while privately pinpointing aspects of Darwin's views of inheritance that were not supported by Mendel's own experiments.
Additional Links: PMID-31848463
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Citation:
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@article {pmid31848463,
year = {2020},
author = {Fairbanks, DJ},
title = {Mendel and Darwin: untangling a persistent enigma.},
journal = {Heredity},
volume = {124},
number = {2},
pages = {263-273},
pmid = {31848463},
issn = {1365-2540},
mesh = {*Biological Evolution ; Genetic Research/*history ; History, 19th Century ; Humans ; *Selection, Genetic ; },
abstract = {Mendel and Darwin were contemporaries, with much overlap in their scientifically productive years. Available evidence shows that Mendel knew much about Darwin, whereas Darwin knew nothing of Mendel. Because of the fragmentary nature of this evidence, published inferences regarding Mendel's views on Darwinian evolution are contradictory and enigmatic, with claims ranging from enthusiastic acceptance to outright rejection. The objective of this review is to examine evidence from Mendel's published and private writings on evolution and Darwin, and the influence of the scientific environment in which he was immersed. Much of this evidence lies in Mendel's handwritten annotations in his copies of Darwin's books, which this review scrutinises in detail. Darwin's writings directly influenced Mendel's classic 1866 paper, and his letters to Nägeli. He commended and criticised Darwin on specific issues pertinent to his research, including the provisional hypothesis of pangenesis, the role of pollen in fertilisation, and the influence of "conditions of life" on heritable variation. In his final letter to Nägeli, Mendel proposed a Darwinian scenario for natural selection using the same German term for "struggle for existence" as in his copies of Darwin's books. His published and private scientific writings are entirely objective, devoid of polemics or religious allusions, and address evolutionary questions in a manner consistent with that of his scientific contemporaries. The image that emerges of Mendel is of a meticulous scientist who accepted the tenets of Darwinian evolution, while privately pinpointing aspects of Darwin's views of inheritance that were not supported by Mendel's own experiments.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
*Biological Evolution
Genetic Research/*history
History, 19th Century
Humans
*Selection, Genetic
RevDate: 2020-07-10
CmpDate: 2020-07-10
From Gregor Mendel to Eric Davidson: Mathematical Models and Basic Principles in Biology.
Journal of computational biology : a journal of computational molecular cell biology, 26(7):637-652.
Mathematical models have been widespread in biology since its emergence as a modern experimental science in the 19th century. Focusing on models in developmental biology and heredity, this article (1) presents the properties and epistemological basis of pertinent mathematical models in biology from Mendel's model of heredity in the 19th century to Eric Davidson's model of developmental gene regulatory networks in the 21st; (2) shows that the models differ not only in their epistemologies but also in regard to explicitly or implicitly taking into account basic biological principles, in particular those of biological specificity (that became, in part, replaced by genetic information) and genetic causality. The article claims that models disregarding these principles did not impact the direction of biological research in a lasting way, although some of them, such as D'Arcy Thompson's models of biological form, were widely read and admired and others, such as Turing's models of development, stimulated research in other fields. Moreover, it suggests that successful models were not purely mathematical descriptions or simulations of biological phenomena but were based on inductive, as well as hypothetico-deductive, methodology. The recent availability of large amounts of sequencing data and new computational methodology tremendously facilitates system approaches and pattern recognition in many fields of research. Although these new technologies have given rise to claims that correlation is replacing experimentation and causal analysis, the article argues that the inductive and hypothetico-deductive experimental methodologies have remained fundamentally important as long as causal-mechanistic explanations of complex systems are pursued.
Additional Links: PMID-31120326
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Citation:
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@article {pmid31120326,
year = {2019},
author = {Deichmann, U},
title = {From Gregor Mendel to Eric Davidson: Mathematical Models and Basic Principles in Biology.},
journal = {Journal of computational biology : a journal of computational molecular cell biology},
volume = {26},
number = {7},
pages = {637-652},
pmid = {31120326},
issn = {1557-8666},
mesh = {Computer Simulation ; Gene Regulatory Networks ; Genetic Code ; History, 20th Century ; *Models, Biological ; *Models, Theoretical ; },
abstract = {Mathematical models have been widespread in biology since its emergence as a modern experimental science in the 19th century. Focusing on models in developmental biology and heredity, this article (1) presents the properties and epistemological basis of pertinent mathematical models in biology from Mendel's model of heredity in the 19th century to Eric Davidson's model of developmental gene regulatory networks in the 21st; (2) shows that the models differ not only in their epistemologies but also in regard to explicitly or implicitly taking into account basic biological principles, in particular those of biological specificity (that became, in part, replaced by genetic information) and genetic causality. The article claims that models disregarding these principles did not impact the direction of biological research in a lasting way, although some of them, such as D'Arcy Thompson's models of biological form, were widely read and admired and others, such as Turing's models of development, stimulated research in other fields. Moreover, it suggests that successful models were not purely mathematical descriptions or simulations of biological phenomena but were based on inductive, as well as hypothetico-deductive, methodology. The recent availability of large amounts of sequencing data and new computational methodology tremendously facilitates system approaches and pattern recognition in many fields of research. Although these new technologies have given rise to claims that correlation is replacing experimentation and causal analysis, the article argues that the inductive and hypothetico-deductive experimental methodologies have remained fundamentally important as long as causal-mechanistic explanations of complex systems are pursued.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Computer Simulation
Gene Regulatory Networks
Genetic Code
History, 20th Century
*Models, Biological
*Models, Theoretical
RevDate: 2019-09-12
CmpDate: 2019-09-12
Darwin and Mendel: The Historical Connection.
Advances in genetics, 102:1-25.
Darwin carried out a host of carefully controlled cross- and self-pollination experiments in a wide variety of plants, and made a significant and imperishable contribution to the knowledge of hybridization. He not only clearly described the phenomenon of what he called prepotency and what we now call dominance or Mendelian inheritance, but also explained it by his Pangenesis. Recent discovery of small RNAs acting as dominance modifiers supports his Pangenesis regarding the control of prepotency by gemmules. Historical studies show that there is striking evidence that Mendel read Darwin's The Origin of Species, which had influenced his paper presented in 1865 and published in 1866. Although Mendel's paper has been considered a classic in the history of genetics, it generated much controversy since its rediscovery. Mendel's position as the father of genetics is being seriously challenged. Darwin's main contribution to genetics was the collection of a tremendous amount of genetic data, and the formulation of a comprehensive genetical theory for their explanation. Over the past 150 years, however, Darwin's legacy to genetics, particularly his Pangenesis, has not been considered seriously by most geneticists. It is proposed that Darwin should have been regarded as one of the most important pioneers in genetics.
Additional Links: PMID-30122232
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PubMed:
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@article {pmid30122232,
year = {2018},
author = {Liu, Y},
title = {Darwin and Mendel: The Historical Connection.},
journal = {Advances in genetics},
volume = {102},
number = {},
pages = {1-25},
doi = {10.1016/bs.adgen.2018.05.006},
pmid = {30122232},
issn = {0065-2660},
mesh = {Animals ; *Biological Evolution ; Plants/genetics ; Selection, Genetic ; },
abstract = {Darwin carried out a host of carefully controlled cross- and self-pollination experiments in a wide variety of plants, and made a significant and imperishable contribution to the knowledge of hybridization. He not only clearly described the phenomenon of what he called prepotency and what we now call dominance or Mendelian inheritance, but also explained it by his Pangenesis. Recent discovery of small RNAs acting as dominance modifiers supports his Pangenesis regarding the control of prepotency by gemmules. Historical studies show that there is striking evidence that Mendel read Darwin's The Origin of Species, which had influenced his paper presented in 1865 and published in 1866. Although Mendel's paper has been considered a classic in the history of genetics, it generated much controversy since its rediscovery. Mendel's position as the father of genetics is being seriously challenged. Darwin's main contribution to genetics was the collection of a tremendous amount of genetic data, and the formulation of a comprehensive genetical theory for their explanation. Over the past 150 years, however, Darwin's legacy to genetics, particularly his Pangenesis, has not been considered seriously by most geneticists. It is proposed that Darwin should have been regarded as one of the most important pioneers in genetics.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
*Biological Evolution
Plants/genetics
Selection, Genetic
RevDate: 2018-01-11
CmpDate: 2018-01-11
Experiments on Plant Hybrids by Gregor Mendel.
Genetics, 204(2):407-422.
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@article {pmid27729492,
year = {2016},
author = {Abbott, S and Fairbanks, DJ},
title = {Experiments on Plant Hybrids by Gregor Mendel.},
journal = {Genetics},
volume = {204},
number = {2},
pages = {407-422},
doi = {10.1534/genetics.116.195198},
pmid = {27729492},
issn = {1943-2631},
mesh = {Genetics ; History, 19th Century ; Inheritance Patterns/*genetics ; Peas/*genetics ; Plants ; },
}
MeSH Terms:
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Genetics
History, 19th Century
Inheritance Patterns/*genetics
Peas/*genetics
Plants
RevDate: 2019-01-12
CmpDate: 2017-05-23
Darwin's Influence on Mendel: Evidence from a New Translation of Mendel's Paper.
Genetics, 204(2):401-405.
Gregor Mendel's classic paper, Versuche über Pflanzen-Hybriden (Experiments on Plant Hybrids), was published in 1866, hence 2016 is its sesquicentennial. Mendel completed his experiments in 1863 and shortly thereafter began compiling the results and writing his paper, which he presented in meetings of the Natural Science Society in Brünn in February and March of 1865. Mendel owned a personal copy of Darwin's Origin of Species, a German translation published in 1863, and it contains his marginalia. Its publication date indicates that Mendel's study of Darwin's book could have had no influence while he was conducting his experiments but its publication date coincided with the period of time when he was preparing his paper, making it possible that Darwin's writings influenced Mendel's interpretations and theory. Based on this premise, we prepared a Darwinized English translation of Mendel's paper by comparing German terms Mendel employed with the same terms in the German translation of Origin of Species in his possession, then using Darwin's counterpart English words and phrases as much as possible in our translation. We found a substantially higher use of these terms in the final two (10th and 11th) sections of Mendel's paper, particularly in one key paragraph, where Mendel reflects on evolutionary issues, providing strong evidence of Darwin's influence on Mendel.
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@article {pmid27729491,
year = {2016},
author = {Fairbanks, DJ and Abbott, S},
title = {Darwin's Influence on Mendel: Evidence from a New Translation of Mendel's Paper.},
journal = {Genetics},
volume = {204},
number = {2},
pages = {401-405},
pmid = {27729491},
issn = {1943-2631},
mesh = {Biological Evolution ; Genetics/*history ; History, 19th Century ; *Selection, Genetic ; },
abstract = {Gregor Mendel's classic paper, Versuche über Pflanzen-Hybriden (Experiments on Plant Hybrids), was published in 1866, hence 2016 is its sesquicentennial. Mendel completed his experiments in 1863 and shortly thereafter began compiling the results and writing his paper, which he presented in meetings of the Natural Science Society in Brünn in February and March of 1865. Mendel owned a personal copy of Darwin's Origin of Species, a German translation published in 1863, and it contains his marginalia. Its publication date indicates that Mendel's study of Darwin's book could have had no influence while he was conducting his experiments but its publication date coincided with the period of time when he was preparing his paper, making it possible that Darwin's writings influenced Mendel's interpretations and theory. Based on this premise, we prepared a Darwinized English translation of Mendel's paper by comparing German terms Mendel employed with the same terms in the German translation of Origin of Species in his possession, then using Darwin's counterpart English words and phrases as much as possible in our translation. We found a substantially higher use of these terms in the final two (10th and 11th) sections of Mendel's paper, particularly in one key paragraph, where Mendel reflects on evolutionary issues, providing strong evidence of Darwin's influence on Mendel.},
}
MeSH Terms:
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Biological Evolution
Genetics/*history
History, 19th Century
*Selection, Genetic
RevDate: 2017-02-23
CmpDate: 2017-02-23
From Mendel to epigenetics: History of genetics.
Comptes rendus biologies, 339(7-8):225-230.
The origins of genetics are to be found in Gregor Mendel's memoir on plant hybridization (1865). However, the word 'genetics' was only coined in 1906, to designate the new science of heredity. Founded upon the Mendelian method for analyzing the products of crosses, this science is distinguished by its explicit purpose of being a general 'science of heredity', and by the introduction of totally new biological concepts (in particular those of gene, genotype, and phenotype). In the 1910s, Mendelian genetics fused with the chromosomal theory of inheritance, giving rise to what is still called 'classical genetics'. Within this framework, the gene is simultaneously a unit of function and transmission, a unit of recombination, and of mutation. Until the early 1950s, these concepts of the gene coincided. But when DNA was found to be the material basis of inheritance, this congruence dissolved. Then began the venture of molecular biology, which has never stopped revealing the complexity of the way in which hereditary material functions.
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@article {pmid27263362,
year = {2016},
author = {Gayon, J},
title = {From Mendel to epigenetics: History of genetics.},
journal = {Comptes rendus biologies},
volume = {339},
number = {7-8},
pages = {225-230},
doi = {10.1016/j.crvi.2016.05.009},
pmid = {27263362},
issn = {1768-3238},
mesh = {Animals ; Epigenomics/*history/trends ; Genes ; Genetics/*history/trends ; History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Molecular Biology/history/trends ; Plants/genetics ; },
abstract = {The origins of genetics are to be found in Gregor Mendel's memoir on plant hybridization (1865). However, the word 'genetics' was only coined in 1906, to designate the new science of heredity. Founded upon the Mendelian method for analyzing the products of crosses, this science is distinguished by its explicit purpose of being a general 'science of heredity', and by the introduction of totally new biological concepts (in particular those of gene, genotype, and phenotype). In the 1910s, Mendelian genetics fused with the chromosomal theory of inheritance, giving rise to what is still called 'classical genetics'. Within this framework, the gene is simultaneously a unit of function and transmission, a unit of recombination, and of mutation. Until the early 1950s, these concepts of the gene coincided. But when DNA was found to be the material basis of inheritance, this congruence dissolved. Then began the venture of molecular biology, which has never stopped revealing the complexity of the way in which hereditary material functions.},
}
MeSH Terms:
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Animals
Epigenomics/*history/trends
Genes
Genetics/*history/trends
History, 19th Century
History, 20th Century
History, 21st Century
Humans
Molecular Biology/history/trends
Plants/genetics
RevDate: 2018-11-13
CmpDate: 2016-01-20
Johann Gregor Mendel: paragon of experimental science.
Molecular genetics & genomic medicine, 4(1):3-8.
This is a foreword on the life and work of one of the greatest minds of the 20th century, the father of modern genetics, Johann Gregor Mendel.
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@article {pmid26788542,
year = {2016},
author = {De Castro, M},
title = {Johann Gregor Mendel: paragon of experimental science.},
journal = {Molecular genetics & genomic medicine},
volume = {4},
number = {1},
pages = {3-8},
pmid = {26788542},
issn = {2324-9269},
abstract = {This is a foreword on the life and work of one of the greatest minds of the 20th century, the father of modern genetics, Johann Gregor Mendel.},
}
RevDate: 2016-01-10
CmpDate: 2016-01-07
Remembering Johann Gregor Mendel: a human, a Catholic priest, an Augustinian monk, and abbot.
Molecular genetics & genomic medicine, 3(6):483-485 pii:MGG3186.
Johann Mendel (Gregor was the name given to him only later by his Augustinian order, Fig. 1) was born on July 20, 1822 to an ethnic German family, Anton and Rosina Mendel (Fig. 2), in Heinzendorf in the Austrian Empire at the Moravian-Silesian border (now Hynčice, Czech Republic).
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@article {pmid26740939,
year = {2015},
author = {Richter, FC},
title = {Remembering Johann Gregor Mendel: a human, a Catholic priest, an Augustinian monk, and abbot.},
journal = {Molecular genetics & genomic medicine},
volume = {3},
number = {6},
pages = {483-485},
doi = {10.1002/mgg3.186},
pmid = {26740939},
issn = {2324-9269},
abstract = {Johann Mendel (Gregor was the name given to him only later by his Augustinian order, Fig. 1) was born on July 20, 1822 to an ethnic German family, Anton and Rosina Mendel (Fig. 2), in Heinzendorf in the Austrian Empire at the Moravian-Silesian border (now Hynčice, Czech Republic).},
}
RevDate: 2018-12-02
CmpDate: 2016-07-28
Darwin and Mendel today: a comment on "Limits of imagination: the 150th Anniversary of Mendel's Laws, and why Mendel failed to see the importance of his discovery for Darwin's theory of evolution".
Genome, 59(1):75-77.
We comment on a recent paper by Rama Singh, who concludes that Mendel deserved to be called the father of genetics, and Darwin would not have understood the significance of Mendel's paper had he read it. We argue that Darwin should have been regarded as the father of genetics not only because he was the first to formulate a unifying theory of heredity, variation, and development -- Pangenesis, but also because he clearly described almost all genetical phenomena of fundamental importance, including what he called "prepotency" and what we now call "dominance" or "Mendelian inheritance". The word "gene" evolved from Darwin's imagined "gemmules", instead of Mendel's so-called "factors".
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@article {pmid26651239,
year = {2016},
author = {Liu, Y and Li, X},
title = {Darwin and Mendel today: a comment on "Limits of imagination: the 150th Anniversary of Mendel's Laws, and why Mendel failed to see the importance of his discovery for Darwin's theory of evolution".},
journal = {Genome},
volume = {59},
number = {1},
pages = {75-77},
doi = {10.1139/gen-2015-0155},
pmid = {26651239},
issn = {1480-3321},
mesh = {*Biological Evolution ; Genetic Research/*history ; *Imagination ; *Selection, Genetic ; },
abstract = {We comment on a recent paper by Rama Singh, who concludes that Mendel deserved to be called the father of genetics, and Darwin would not have understood the significance of Mendel's paper had he read it. We argue that Darwin should have been regarded as the father of genetics not only because he was the first to formulate a unifying theory of heredity, variation, and development -- Pangenesis, but also because he clearly described almost all genetical phenomena of fundamental importance, including what he called "prepotency" and what we now call "dominance" or "Mendelian inheritance". The word "gene" evolved from Darwin's imagined "gemmules", instead of Mendel's so-called "factors".},
}
MeSH Terms:
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*Biological Evolution
Genetic Research/*history
*Imagination
*Selection, Genetic
RevDate: 2018-12-02
CmpDate: 2016-01-05
John Gregor Mendel (1822-1884).
The Journal of the Association of Physicians of India, 63(3):60-61.
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@article {pmid26540846,
year = {2015},
author = {Pai-Dhungat, JV},
title = {John Gregor Mendel (1822-1884).},
journal = {The Journal of the Association of Physicians of India},
volume = {63},
number = {3},
pages = {60-61},
pmid = {26540846},
issn = {0004-5772},
mesh = {Czech Republic ; Genetics/*history ; History, 19th Century ; *Philately ; },
}
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Czech Republic
Genetics/*history
History, 19th Century
*Philately
RevDate: 2015-09-26
CmpDate: 2015-12-22
Mendel, mechanism, models, marketing, and more.
Cell, 163(1):9-11.
This year marks the 150(th) anniversary of the presentation by Gregor Mendel of his studies of plant hybridization to the Brunn Natural History Society. Their nature and meaning have been discussed many times. However, on this occasion, we reflect on the scientific enterprise and the perception of new discoveries.
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@article {pmid26406361,
year = {2015},
author = {Birchler, JA},
title = {Mendel, mechanism, models, marketing, and more.},
journal = {Cell},
volume = {163},
number = {1},
pages = {9-11},
doi = {10.1016/j.cell.2015.09.008},
pmid = {26406361},
issn = {1097-4172},
mesh = {Animals ; Chickens/genetics ; Crosses, Genetic ; Genetics/*history ; History, 18th Century ; *Models, Genetic ; Peas/genetics ; Zea mays/genetics ; },
abstract = {This year marks the 150(th) anniversary of the presentation by Gregor Mendel of his studies of plant hybridization to the Brunn Natural History Society. Their nature and meaning have been discussed many times. However, on this occasion, we reflect on the scientific enterprise and the perception of new discoveries.},
}
MeSH Terms:
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Animals
Chickens/genetics
Crosses, Genetic
Genetics/*history
History, 18th Century
*Models, Genetic
Peas/genetics
Zea mays/genetics
RevDate: 2016-10-20
CmpDate: 2016-07-27
Limits of imagination: the 150th Anniversary of Mendel's Laws, and why Mendel failed to see the importance of his discovery for Darwin's theory of evolution.
Genome, 58(9):415-421.
Mendel is credited for discovering Laws of Heredity, but his work has come under criticism on three grounds: for possible falsification of data to fit his expectations, for getting undue credit for the laws of heredity without having ideas of segregation and independent assortment, and for being interested in the development of hybrids rather than in the laws of heredity. I present a brief review of these criticisms and conclude that Mendel deserved to be called the father of genetics even if he may not, and most likely did not, have clear ideas of segregation and particulate determiners as we know them now. I argue that neither Mendel understood the evolutionary significance of his findings for the problem of genetic variation, nor would Darwin have understood their significance had he read Mendel's paper. I argue that the limits to imagination, in both cases, came from their mental framework being shaped by existing paradigms-blending inheritance in the case of Darwin, hybrid development in the case of Mendel. Like Einstein, Darwin's natural selection was deterministic; like Niels Bohr, Mendel's Laws were probabilistic-based on random segregation of trait-determining "factors". Unlike Einstein who understood quantum mechanics, Darwin would have been at a loss with Mendel's paper with no guide to turn to. Geniuses in their imaginations are like heat-seeking missiles locked-in with their targets of deep interests and they generally see things in one dimension only. Imagination has limits; unaided imagination is like a bird without wings--it goes nowhere.
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@article {pmid26372894,
year = {2015},
author = {Singh, RS},
title = {Limits of imagination: the 150th Anniversary of Mendel's Laws, and why Mendel failed to see the importance of his discovery for Darwin's theory of evolution.},
journal = {Genome},
volume = {58},
number = {9},
pages = {415-421},
doi = {10.1139/gen-2015-0107},
pmid = {26372894},
issn = {1480-3321},
mesh = {Anniversaries and Special Events ; *Biological Evolution ; Genetic Research/*history ; Genetic Variation ; History, 19th Century ; History, 20th Century ; *Imagination ; *Selection, Genetic ; },
abstract = {Mendel is credited for discovering Laws of Heredity, but his work has come under criticism on three grounds: for possible falsification of data to fit his expectations, for getting undue credit for the laws of heredity without having ideas of segregation and independent assortment, and for being interested in the development of hybrids rather than in the laws of heredity. I present a brief review of these criticisms and conclude that Mendel deserved to be called the father of genetics even if he may not, and most likely did not, have clear ideas of segregation and particulate determiners as we know them now. I argue that neither Mendel understood the evolutionary significance of his findings for the problem of genetic variation, nor would Darwin have understood their significance had he read Mendel's paper. I argue that the limits to imagination, in both cases, came from their mental framework being shaped by existing paradigms-blending inheritance in the case of Darwin, hybrid development in the case of Mendel. Like Einstein, Darwin's natural selection was deterministic; like Niels Bohr, Mendel's Laws were probabilistic-based on random segregation of trait-determining "factors". Unlike Einstein who understood quantum mechanics, Darwin would have been at a loss with Mendel's paper with no guide to turn to. Geniuses in their imaginations are like heat-seeking missiles locked-in with their targets of deep interests and they generally see things in one dimension only. Imagination has limits; unaided imagination is like a bird without wings--it goes nowhere.},
}
MeSH Terms:
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Anniversaries and Special Events
*Biological Evolution
Genetic Research/*history
Genetic Variation
History, 19th Century
History, 20th Century
*Imagination
*Selection, Genetic
RevDate: 2018-12-03
CmpDate: 2017-03-07
Mendel at the sesquicentennial of 'Versuche über Pflanzen-Hybriden' (1865): The root of the biggest legend in the history of science.
Endeavour, 39(2):106-115.
In 1965, Mendel was still celebrated as the undisputed founder of genetics. In the ensuing 50 years, scholars questioned and undermined this traditional interpretation of his experiments with hybrid plants, without, however, managing to replace it: at the sesquicentennial of the presentation of his 'Versuche' (1865), the Moravian friar remains, to a vast majority, the heroic Father of genetics or at least some kind of geneticist. This exceptionally inert myth is nourished by ontological intuitions but can only continue to flourish, thanks to a long-standing conceptual void in the historiography of biology. It is merely a symptom of this more fundamental problem.
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@article {pmid26094058,
year = {2015},
author = {Tanghe, KB},
title = {Mendel at the sesquicentennial of 'Versuche über Pflanzen-Hybriden' (1865): The root of the biggest legend in the history of science.},
journal = {Endeavour},
volume = {39},
number = {2},
pages = {106-115},
doi = {10.1016/j.endeavour.2015.05.004},
pmid = {26094058},
issn = {1873-1929},
mesh = {Genetics/*history ; History, 19th Century ; Humans ; Male ; Mythology/*psychology ; },
abstract = {In 1965, Mendel was still celebrated as the undisputed founder of genetics. In the ensuing 50 years, scholars questioned and undermined this traditional interpretation of his experiments with hybrid plants, without, however, managing to replace it: at the sesquicentennial of the presentation of his 'Versuche' (1865), the Moravian friar remains, to a vast majority, the heroic Father of genetics or at least some kind of geneticist. This exceptionally inert myth is nourished by ontological intuitions but can only continue to flourish, thanks to a long-standing conceptual void in the historiography of biology. It is merely a symptom of this more fundamental problem.},
}
MeSH Terms:
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Genetics/*history
History, 19th Century
Humans
Male
Mythology/*psychology
RevDate: 2015-02-19
CmpDate: 2015-03-04
Plant genetics: Czech centre marks Mendel anniversary.
Nature, 518(7539):303.
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@article {pmid25693553,
year = {2015},
author = {Matalová, A and Matalová, E},
title = {Plant genetics: Czech centre marks Mendel anniversary.},
journal = {Nature},
volume = {518},
number = {7539},
pages = {303},
doi = {10.1038/518303e},
pmid = {25693553},
issn = {1476-4687},
mesh = {Anniversaries and Special Events ; Czech Republic ; Genetics/*history ; History, 19th Century ; History, 21st Century ; *Museums ; Plants/*genetics ; },
}
MeSH Terms:
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Anniversaries and Special Events
Czech Republic
Genetics/*history
History, 19th Century
History, 21st Century
*Museums
Plants/*genetics
RevDate: 2018-11-13
CmpDate: 2015-01-28
MENDEL: Morphologist and Mathematician Founder of Genetics - To Begin a Celebration of the 2015 Sesquicentennial of Mendel's Presentation in 1865 of his Versuche über Pflanzenhybriden.
Molecular genetics & genomic medicine, 3(1):1-7.
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@article {pmid25629074,
year = {2015},
author = {Opitz, JM and Bianchi, DW},
title = {MENDEL: Morphologist and Mathematician Founder of Genetics - To Begin a Celebration of the 2015 Sesquicentennial of Mendel's Presentation in 1865 of his Versuche über Pflanzenhybriden.},
journal = {Molecular genetics & genomic medicine},
volume = {3},
number = {1},
pages = {1-7},
pmid = {25629074},
issn = {2324-9269},
}
RevDate: 2018-11-13
CmpDate: 2012-09-06
Mendel: a simple excel workbook to compare the observed and expected distributions of genotypes/phenotypes in transgenic and knockout mouse crosses involving up to three unlinked loci by means of a χ2 test.
Transgenic research, 21(3):677-681.
The analysis of transgenic and knockout mice always involves the establishment of matings with individuals carrying different loci, segregating independently, whose presence is expected among the progeny, according to a Mendelian distribution. The appearance of distorted inheritance ratios suggests the existence of unexpected lethal or sub-lethal phenotypes associated with some genotypes. These situations are common in a number of cases, including: testing transgenic founder mice for germ-line transmission of their transgenes; setting up heterozygous crosses to obtain homozygous individuals, both for transgenic and knockout mice; establishing matings between floxed mouse lines and suitable cre transgenic mouse lines, etc. The Pearson's χ(2) test can be used to assess the significance of the observed frequencies of genotypes/phenotypes in relation to the expected values, in order to determine whether the observed cases fit the expected distribution. Here, I describe a simple Excel workbook to compare the observed and expected distributions of genotypes/phenotypes in transgenic and knockout mouse crosses involving up to three unlinked loci by means of a χ(2) test. The file is freely available for download from my laboratory's web page at: http://www.cnb.csic.es/~montoliu/Mendel.xls .
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@article {pmid21853295,
year = {2012},
author = {Montoliu, L},
title = {Mendel: a simple excel workbook to compare the observed and expected distributions of genotypes/phenotypes in transgenic and knockout mouse crosses involving up to three unlinked loci by means of a χ2 test.},
journal = {Transgenic research},
volume = {21},
number = {3},
pages = {677-681},
pmid = {21853295},
issn = {1573-9368},
mesh = {Alleles ; Animals ; Breeding ; Chi-Square Distribution ; Computational Biology/*methods ; *Crosses, Genetic ; Gene Frequency ; Genetic Loci ; *Genotype ; Inheritance Patterns ; Internet ; Mice ; Mice, Knockout ; Mice, Transgenic ; *Phenotype ; *Software ; },
abstract = {The analysis of transgenic and knockout mice always involves the establishment of matings with individuals carrying different loci, segregating independently, whose presence is expected among the progeny, according to a Mendelian distribution. The appearance of distorted inheritance ratios suggests the existence of unexpected lethal or sub-lethal phenotypes associated with some genotypes. These situations are common in a number of cases, including: testing transgenic founder mice for germ-line transmission of their transgenes; setting up heterozygous crosses to obtain homozygous individuals, both for transgenic and knockout mice; establishing matings between floxed mouse lines and suitable cre transgenic mouse lines, etc. The Pearson's χ(2) test can be used to assess the significance of the observed frequencies of genotypes/phenotypes in relation to the expected values, in order to determine whether the observed cases fit the expected distribution. Here, I describe a simple Excel workbook to compare the observed and expected distributions of genotypes/phenotypes in transgenic and knockout mouse crosses involving up to three unlinked loci by means of a χ(2) test. The file is freely available for download from my laboratory's web page at: http://www.cnb.csic.es/~montoliu/Mendel.xls .},
}
MeSH Terms:
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Alleles
Animals
Breeding
Chi-Square Distribution
Computational Biology/*methods
*Crosses, Genetic
Gene Frequency
Genetic Loci
*Genotype
Inheritance Patterns
Internet
Mice
Mice, Knockout
Mice, Transgenic
*Phenotype
*Software
RevDate: 2011-07-27
CmpDate: 2011-08-18
What would have happened if Darwin had known Mendel (or Mendel's work)?.
History and philosophy of the life sciences, 33(1):3-49.
The question posed by the title is usually answered by saying that the "synthesis" between the theory of evolution by natural selection and classical genetics, which took place in 1930s-40s, would have taken place much earlier if Darwin had been aware of Mendel and his work. What is more, it nearly happened: it would have been enough if Darwin had cut the pages of the offprint of Mendel's work that was in his library and read them! Or, if Mendel had come across Darwin in London or paid him a visit at his house in the outskirts! (on occasion of Mendel's trip in 1862 to that city). The aim of the present paper is to provide elements for quite a different answer, based on further historical evidence, especially on Mendel's works, some of which mention Darwins's studies.
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@article {pmid21789954,
year = {2011},
author = {Lorenzano, P},
title = {What would have happened if Darwin had known Mendel (or Mendel's work)?.},
journal = {History and philosophy of the life sciences},
volume = {33},
number = {1},
pages = {3-49},
pmid = {21789954},
issn = {0391-9714},
mesh = {Austria ; Biological Evolution ; England ; Genetic Research/*history ; History, 19th Century ; *Selection, Genetic ; },
abstract = {The question posed by the title is usually answered by saying that the "synthesis" between the theory of evolution by natural selection and classical genetics, which took place in 1930s-40s, would have taken place much earlier if Darwin had been aware of Mendel and his work. What is more, it nearly happened: it would have been enough if Darwin had cut the pages of the offprint of Mendel's work that was in his library and read them! Or, if Mendel had come across Darwin in London or paid him a visit at his house in the outskirts! (on occasion of Mendel's trip in 1862 to that city). The aim of the present paper is to provide elements for quite a different answer, based on further historical evidence, especially on Mendel's works, some of which mention Darwins's studies.},
}
MeSH Terms:
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Austria
Biological Evolution
England
Genetic Research/*history
History, 19th Century
*Selection, Genetic
RevDate: 2011-11-07
CmpDate: 2012-04-17
Mendel, 150 years on.
Trends in plant science, 16(11):590-596.
Mendel's paper 'Versuche über Pflanzen-Hybriden' is the best known in a series of studies published in the late 18th and 19th centuries that built our understanding of the mechanism of inheritance. Mendel investigated the segregation of seven gene characters of pea (Pisum sativum), of which four have been identified. Here, we review what is known about the molecular nature of these genes, which encode enzymes (R and Le), a biochemical regulator (I) and a transcription factor (A). The mutations are: a transposon insertion (r), an amino acid insertion (i), a splice variant (a) and a missense mutation (le-1). The nature of the three remaining uncharacterized characters (green versus yellow pods, inflated versus constricted pods, and axial versus terminal flowers) is discussed.
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@article {pmid21775188,
year = {2011},
author = {Ellis, TH and Hofer, JM and Timmerman-Vaughan, GM and Coyne, CJ and Hellens, RP},
title = {Mendel, 150 years on.},
journal = {Trends in plant science},
volume = {16},
number = {11},
pages = {590-596},
doi = {10.1016/j.tplants.2011.06.006},
pmid = {21775188},
issn = {1878-4372},
mesh = {Flowers/genetics ; Genes ; Genetic Linkage ; Genetics/*history ; History, 18th Century ; History, 19th Century ; Pigmentation/genetics ; Quantitative Trait, Heritable ; },
abstract = {Mendel's paper 'Versuche über Pflanzen-Hybriden' is the best known in a series of studies published in the late 18th and 19th centuries that built our understanding of the mechanism of inheritance. Mendel investigated the segregation of seven gene characters of pea (Pisum sativum), of which four have been identified. Here, we review what is known about the molecular nature of these genes, which encode enzymes (R and Le), a biochemical regulator (I) and a transcription factor (A). The mutations are: a transposon insertion (r), an amino acid insertion (i), a splice variant (a) and a missense mutation (le-1). The nature of the three remaining uncharacterized characters (green versus yellow pods, inflated versus constricted pods, and axial versus terminal flowers) is discussed.},
}
MeSH Terms:
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Flowers/genetics
Genes
Genetic Linkage
Genetics/*history
History, 18th Century
History, 19th Century
Pigmentation/genetics
Quantitative Trait, Heritable
RevDate: 2018-11-13
CmpDate: 2014-06-07
The cold war context of the golden jubilee, or, why we think of mendel as the father of genetics.
Journal of the history of biology, 45(3):389-414.
In September 1950, the Genetics Society of America (GSA) dedicated its annual meeting to a "Golden Jubilee of Genetics" that celebrated the 50th anniversary of the rediscovery of Mendel's work. This program, originally intended as a small ceremony attached to the coattails of the American Institute of Biological Sciences (AIBS) meeting, turned into a publicity juggernaut that generated coverage on Mendel and the accomplishments of Western genetics in countless newspapers and radio broadcasts. The Golden Jubilee merits historical attention as both an intriguing instance of scientific commemoration and as an early example of Cold War political theatre. Instead of condemning either Lysenko or Soviet genetics, the Golden Jubilee would celebrate Mendel - and, not coincidentally, the practical achievements in plant and animal breeding his work had made possible. The American geneticists' focus on the achievements of Western genetics as both practical and theoretical, international, and, above all, non-ideological and non-controversial, was fully intended to demonstrate the success of the Western model of science to both the American public and scientists abroad at a key transition point in the Cold War. An implicit part of this article's argument, therefore, is the pervasive impact of the Cold War in unanticipated corners of postwar scientific culture.
Additional Links: PMID-21656286
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Citation:
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@article {pmid21656286,
year = {2012},
author = {Wolfe, AJ},
title = {The cold war context of the golden jubilee, or, why we think of mendel as the father of genetics.},
journal = {Journal of the history of biology},
volume = {45},
number = {3},
pages = {389-414},
pmid = {21656286},
issn = {0022-5010},
abstract = {In September 1950, the Genetics Society of America (GSA) dedicated its annual meeting to a "Golden Jubilee of Genetics" that celebrated the 50th anniversary of the rediscovery of Mendel's work. This program, originally intended as a small ceremony attached to the coattails of the American Institute of Biological Sciences (AIBS) meeting, turned into a publicity juggernaut that generated coverage on Mendel and the accomplishments of Western genetics in countless newspapers and radio broadcasts. The Golden Jubilee merits historical attention as both an intriguing instance of scientific commemoration and as an early example of Cold War political theatre. Instead of condemning either Lysenko or Soviet genetics, the Golden Jubilee would celebrate Mendel - and, not coincidentally, the practical achievements in plant and animal breeding his work had made possible. The American geneticists' focus on the achievements of Western genetics as both practical and theoretical, international, and, above all, non-ideological and non-controversial, was fully intended to demonstrate the success of the Western model of science to both the American public and scientists abroad at a key transition point in the Cold War. An implicit part of this article's argument, therefore, is the pervasive impact of the Cold War in unanticipated corners of postwar scientific culture.},
}
RevDate: 2009-06-15
CmpDate: 2009-09-30
The "useful questions of heredity" before Mendel.
The Journal of heredity, 100(4):421-423.
Now Emeritus Head of the Mendelianum (Mendel Museum) in Brno, Czech Republic, Vítezslav Orel began his academic career as a student at the Brno Agriculture University. His work was interrupted first by the Nazi invasion and then by the communist revolution, when the science of genetics was denounced and replaced by Lysenko pseudogenetics. V. O. was dismissed from his position at the Poultry Research Institute and assigned to work at a small duck farm outside Brno. When the "Lysenkoist madness" subsided, Professor Jaroslav Krizenecky (1896-1964), teacher of V. O., was allowed to develop the museum in recognition of Mendel's contributions. V. O. assisted him by conducting research on the history of Mendel and of genetics. On Jaroslav Krizenecky's death, V. O. became head of the Mendelianum. V. O. has become an internationally recognized figure in the study of the history of science, having published nearly 200 papers in Czech and 10 other languages. Orel's most recent books, published by Oxford University Press, make use of the rich archives of the Mendelianum that he helped create. Gregor Mendel-The First Geneticist (Orel 1996) is the definitive biography of Mendel, and in 2001, V. O. and co-author R. J. Wood published Genetic Prehistory in Selective Breeding: A Prelude to Mendel. (Biography from Margaret H. Peaslee).
Additional Links: PMID-19494029
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PubMed:
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@article {pmid19494029,
year = {2009},
author = {Orel, V},
title = {The "useful questions of heredity" before Mendel.},
journal = {The Journal of heredity},
volume = {100},
number = {4},
pages = {421-423},
doi = {10.1093/jhered/esp022},
pmid = {19494029},
issn = {1465-7333},
mesh = {Animals ; Breeding/history ; Europe ; Genetics/*history ; *Heredity ; History, 18th Century ; History, 19th Century ; Inbreeding ; Sheep ; },
abstract = {Now Emeritus Head of the Mendelianum (Mendel Museum) in Brno, Czech Republic, Vítezslav Orel began his academic career as a student at the Brno Agriculture University. His work was interrupted first by the Nazi invasion and then by the communist revolution, when the science of genetics was denounced and replaced by Lysenko pseudogenetics. V. O. was dismissed from his position at the Poultry Research Institute and assigned to work at a small duck farm outside Brno. When the "Lysenkoist madness" subsided, Professor Jaroslav Krizenecky (1896-1964), teacher of V. O., was allowed to develop the museum in recognition of Mendel's contributions. V. O. assisted him by conducting research on the history of Mendel and of genetics. On Jaroslav Krizenecky's death, V. O. became head of the Mendelianum. V. O. has become an internationally recognized figure in the study of the history of science, having published nearly 200 papers in Czech and 10 other languages. Orel's most recent books, published by Oxford University Press, make use of the rich archives of the Mendelianum that he helped create. Gregor Mendel-The First Geneticist (Orel 1996) is the definitive biography of Mendel, and in 2001, V. O. and co-author R. J. Wood published Genetic Prehistory in Selective Breeding: A Prelude to Mendel. (Biography from Margaret H. Peaslee).},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
Breeding/history
Europe
Genetics/*history
*Heredity
History, 18th Century
History, 19th Century
Inbreeding
Sheep
RevDate: 2010-11-18
CmpDate: 2010-01-11
Did Darwin read Mendel?.
QJM : monthly journal of the Association of Physicians, 102(8):587-589.
Additional Links: PMID-19286889
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@article {pmid19286889,
year = {2009},
author = {Galton, D},
title = {Did Darwin read Mendel?.},
journal = {QJM : monthly journal of the Association of Physicians},
volume = {102},
number = {8},
pages = {587-589},
doi = {10.1093/qjmed/hcp024},
pmid = {19286889},
issn = {1460-2393},
mesh = {*Biological Evolution ; Correspondence as Topic/history ; Genetic Research/*history ; History, 19th Century ; Humans ; *Hybridization, Genetic ; Interdisciplinary Communication ; Plants/*genetics ; },
}
MeSH Terms:
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*Biological Evolution
Correspondence as Topic/history
Genetic Research/*history
History, 19th Century
Humans
*Hybridization, Genetic
Interdisciplinary Communication
Plants/*genetics
RevDate: 2019-11-10
CmpDate: 2008-04-03
The evolutionary ideas of F. M. (Ladimir) Klacel, teacher of Gregor Mendel.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 151(1):151-155.
Abstract: A philosopher and teacher, F. M. (Ladimir) Klacel (1808-1882), educated in what is now the Czech Republic, developed his own explanation for the origin and interaction of living organisms. Klácel, a member of the Augustinian Monastery in Brno, influenced his younger colleague, Friar Gregor Mendel, who went on to formulate concepts in heredity that are still recognized for their profound insight. A mutual interest in the natural sciences of these two friends provided a basis for their discussions of the relationship between religion, evolution, and society. Klacel's outspoken defense of his proposals caused him to lose favor with both the Church and the authorities, and he immigrated to America in 1869. His failing health and inability to communicate with the English-speaking populace, unfortunately, limited his influence in his new environs. In this paper we trace the roots of Klacel's philosophy and elucidate his incorporation of ideas from Hegel, Darwin, and others. An investigation of Klacel's recipe for a successful society reveals his belief in the universality of life and his optimistic hope for human achievement.
Additional Links: PMID-17690761
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PubMed:
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@article {pmid17690761,
year = {2007},
author = {Peaslee, MH and Orel, V},
title = {The evolutionary ideas of F. M. (Ladimir) Klacel, teacher of Gregor Mendel.},
journal = {Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia},
volume = {151},
number = {1},
pages = {151-155},
doi = {10.5507/bp.2007.030},
pmid = {17690761},
issn = {1213-8118},
mesh = {Animals ; *Biological Evolution ; Czech Republic ; Genetics/*history ; History, 19th Century ; Humans ; United States ; },
abstract = {Abstract: A philosopher and teacher, F. M. (Ladimir) Klacel (1808-1882), educated in what is now the Czech Republic, developed his own explanation for the origin and interaction of living organisms. Klácel, a member of the Augustinian Monastery in Brno, influenced his younger colleague, Friar Gregor Mendel, who went on to formulate concepts in heredity that are still recognized for their profound insight. A mutual interest in the natural sciences of these two friends provided a basis for their discussions of the relationship between religion, evolution, and society. Klacel's outspoken defense of his proposals caused him to lose favor with both the Church and the authorities, and he immigrated to America in 1869. His failing health and inability to communicate with the English-speaking populace, unfortunately, limited his influence in his new environs. In this paper we trace the roots of Klacel's philosophy and elucidate his incorporation of ideas from Hegel, Darwin, and others. An investigation of Klacel's recipe for a successful society reveals his belief in the universality of life and his optimistic hope for human achievement.},
}
MeSH Terms:
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hide MeSH Terms
Animals
*Biological Evolution
Czech Republic
Genetics/*history
History, 19th Century
Humans
United States
RevDate: 2006-12-22
CmpDate: 2007-01-31
Genes and genius: the inheritance of Gregor Mendel.
DNA and cell biology, 25(12):655-658.
Additional Links: PMID-17184166
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PubMed:
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@article {pmid17184166,
year = {2006},
author = {Hackett, S and Feldheim, K and Alvey, M},
title = {Genes and genius: the inheritance of Gregor Mendel.},
journal = {DNA and cell biology},
volume = {25},
number = {12},
pages = {655-658},
doi = {10.1089/dna.2006.25.655},
pmid = {17184166},
issn = {1044-5498},
mesh = {Czech Republic ; Genetics/*history ; History, 19th Century ; },
}
MeSH Terms:
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Czech Republic
Genetics/*history
History, 19th Century
RevDate: 2006-10-31
CmpDate: 2007-01-05
Gregor Mendel (1822-1884): man of God and science.
Singapore medical journal, 47(11):922-923.
Additional Links: PMID-17075656
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@article {pmid17075656,
year = {2006},
author = {Tan, SY and Brown, J},
title = {Gregor Mendel (1822-1884): man of God and science.},
journal = {Singapore medical journal},
volume = {47},
number = {11},
pages = {922-923},
pmid = {17075656},
issn = {0037-5675},
mesh = {Famous Persons ; Genetics/*history ; History, 19th Century ; Humans ; Philately ; },
}
MeSH Terms:
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Famous Persons
Genetics/*history
History, 19th Century
Humans
Philately
RevDate: 2019-11-10
CmpDate: 2007-02-20
The 1909 Darwin celebration. Reexamining evolution in the light of Mendel, mutation, and meiosis.
Isis; an international review devoted to the history of science and its cultural influences, 97(3):447-484.
In June 1909, scientists and dignitaries from 167 different countries gathered in Cambridge to celebrate the hundredth anniversary of Charles Darwin's birth and the fiftieth anniversary of the publication of Origin of Species. The event was one of the most magnificent commemorations in the annals of science. Delegates gathered within the cloisters of Cambridge University not only to honor the "hero" of evolution but also to reassess the underpinnings of Darwinism at a critical juncture. With the mechanism of natural selection increasingly under attack, evolutionary theory was in disarray. Against this backdrop, biologists weighed the impact of several new developments--the rediscovery of Mendel's laws of heredity, de Vriesian mutation theory, and the linkage of sex-cell division (recently named "meiosis") to the mechanism of heredity. The 1909 Darwin celebration thus represents a significant watershed in the history of modem biology that allows historians to assess the status of evolution prior to the advent of the chromosome theory of genetics.
Additional Links: PMID-17059108
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PubMed:
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@article {pmid17059108,
year = {2006},
author = {Richmond, ML},
title = {The 1909 Darwin celebration. Reexamining evolution in the light of Mendel, mutation, and meiosis.},
journal = {Isis; an international review devoted to the history of science and its cultural influences},
volume = {97},
number = {3},
pages = {447-484},
doi = {10.1086/508076},
pmid = {17059108},
issn = {0021-1753},
mesh = {Anniversaries and Special Events ; *Famous Persons ; Genetic Research/*history ; Genetics/*history ; History, 19th Century ; History, 20th Century ; Humans ; Hybridization, Genetic ; Inheritance Patterns ; Interprofessional Relations ; Natural History/*history ; Societies, Scientific/history ; United States ; },
abstract = {In June 1909, scientists and dignitaries from 167 different countries gathered in Cambridge to celebrate the hundredth anniversary of Charles Darwin's birth and the fiftieth anniversary of the publication of Origin of Species. The event was one of the most magnificent commemorations in the annals of science. Delegates gathered within the cloisters of Cambridge University not only to honor the "hero" of evolution but also to reassess the underpinnings of Darwinism at a critical juncture. With the mechanism of natural selection increasingly under attack, evolutionary theory was in disarray. Against this backdrop, biologists weighed the impact of several new developments--the rediscovery of Mendel's laws of heredity, de Vriesian mutation theory, and the linkage of sex-cell division (recently named "meiosis") to the mechanism of heredity. The 1909 Darwin celebration thus represents a significant watershed in the history of modem biology that allows historians to assess the status of evolution prior to the advent of the chromosome theory of genetics.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Anniversaries and Special Events
*Famous Persons
Genetic Research/*history
Genetics/*history
History, 19th Century
History, 20th Century
Humans
Hybridization, Genetic
Inheritance Patterns
Interprofessional Relations
Natural History/*history
Societies, Scientific/history
United States
RevDate: 2018-12-01
CmpDate: 2006-07-25
[1848: Gregor Mendel, the monk who wanted to be a citizen].
Medecine sciences : M/S, 22(4):430-433.
This article proposes a previously unpublished French translation of a petition, in German, addressed by six Augustinian friars to the Constitutional Parliament of Vienna in the revolutionary year 1848. The petition states that members of religious orders are deprived of civil rights and demands that they be given citizenship ; it also contains a bitter attack on the monastic institution. We suggest that Mendel was the author of this text, which he signed and actually hand-wrote.
Additional Links: PMID-16597414
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@article {pmid16597414,
year = {2006},
author = {Nivet, C},
title = {[1848: Gregor Mendel, the monk who wanted to be a citizen].},
journal = {Medecine sciences : M/S},
volume = {22},
number = {4},
pages = {430-433},
doi = {10.1051/medsci/2006224430},
pmid = {16597414},
issn = {0767-0974},
mesh = {Austria ; Authorship ; Catholicism/history ; Dissent and Disputes/*history ; Genetics/*history ; History, 19th Century ; Human Rights/*history/legislation & jurisprudence ; Humans ; Politics ; },
abstract = {This article proposes a previously unpublished French translation of a petition, in German, addressed by six Augustinian friars to the Constitutional Parliament of Vienna in the revolutionary year 1848. The petition states that members of religious orders are deprived of civil rights and demands that they be given citizenship ; it also contains a bitter attack on the monastic institution. We suggest that Mendel was the author of this text, which he signed and actually hand-wrote.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Austria
Authorship
Catholicism/history
Dissent and Disputes/*history
Genetics/*history
History, 19th Century
Human Rights/*history/legislation & jurisprudence
Humans
Politics
RevDate: 2016-11-24
CmpDate: 2005-12-09
Darwin and Mendel: who was the pioneer of genetics?.
Rivista di biologia, 98(2):305-322.
Although Mendel is now widely recognized as the founder of genetics, historical studies have shown that he did not in fact propose the modern concept of paired characters linked to genes, nor did he formulate the two "Mendelian laws" in the form now given. Furthermore, Mendel was accused of falsifying his data, and Mendelism has been met with scepticism because of its failure to provide scientific explanation for evolution, to furnish a basis for the process of genetic assimilation and to explain the inheritance of acquired characters, graft hybridization and many other facts. Darwin was the first to clearly describe almost all genetical phenomena of fundamental importance, and was the first to present a developmental theory of heredity--Pangenesis, which not only greatly influenced many subsequent theories of inheritance, particularly those of de Vries, Galton, Brooks and Weismann, but also tied all aspects of variation, heredity and development together, provided a mechanism for most of the observable facts, and is supported by increasing evidence. It has also been indicated that Darwin's influence on Mendel, primarily from The Origin, is evident. The word "gene" was derived from "pangen", itself a derivative of "Pangenesis" which Darwin had coined. It seems that Darwin should have been regarded as the pioneer, if not of transmissional genetics, of developmental genetics and molecular genetics.
Additional Links: PMID-16180199
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@article {pmid16180199,
year = {2005},
author = {Liu, Y},
title = {Darwin and Mendel: who was the pioneer of genetics?.},
journal = {Rivista di biologia},
volume = {98},
number = {2},
pages = {305-322},
pmid = {16180199},
issn = {0035-6050},
mesh = {Animals ; Austria ; Biological Evolution ; Genetic Research/*history ; Genetics/*history ; History, 19th Century ; Humans ; *Hybridization, Genetic/genetics ; *Inheritance Patterns/genetics ; Plants ; Selection, Genetic ; United Kingdom ; },
abstract = {Although Mendel is now widely recognized as the founder of genetics, historical studies have shown that he did not in fact propose the modern concept of paired characters linked to genes, nor did he formulate the two "Mendelian laws" in the form now given. Furthermore, Mendel was accused of falsifying his data, and Mendelism has been met with scepticism because of its failure to provide scientific explanation for evolution, to furnish a basis for the process of genetic assimilation and to explain the inheritance of acquired characters, graft hybridization and many other facts. Darwin was the first to clearly describe almost all genetical phenomena of fundamental importance, and was the first to present a developmental theory of heredity--Pangenesis, which not only greatly influenced many subsequent theories of inheritance, particularly those of de Vries, Galton, Brooks and Weismann, but also tied all aspects of variation, heredity and development together, provided a mechanism for most of the observable facts, and is supported by increasing evidence. It has also been indicated that Darwin's influence on Mendel, primarily from The Origin, is evident. The word "gene" was derived from "pangen", itself a derivative of "Pangenesis" which Darwin had coined. It seems that Darwin should have been regarded as the pioneer, if not of transmissional genetics, of developmental genetics and molecular genetics.},
}
MeSH Terms:
show MeSH Terms
hide MeSH Terms
Animals
Austria
Biological Evolution
Genetic Research/*history
Genetics/*history
History, 19th Century
Humans
*Hybridization, Genetic/genetics
*Inheritance Patterns/genetics
Plants
Selection, Genetic
United Kingdom
RevDate: 2019-05-03
CmpDate: 2003-12-10
Gregor Mendel, OSA (1822-1884), founder of scientific genetics.
Archives of disease in childhood. Fetal and neonatal edition, 88(6):F537-9.
Gregor Mendel, an Augustinian monk and part-time school teacher, undertook a series of brilliant hybridisation experiments with garden peas between 1857 and 1864 in the monastery gardens and, using statistical methods for the first time in biology, established the laws of heredity, thereby establishing the discipline of genetics.
Additional Links: PMID-14602707
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@article {pmid14602707,
year = {2003},
author = {Dunn, PM},
title = {Gregor Mendel, OSA (1822-1884), founder of scientific genetics.},
journal = {Archives of disease in childhood. Fetal and neonatal edition},
volume = {88},
number = {6},
pages = {F537-9},
doi = {10.1136/fn.88.6.f537},
pmid = {14602707},
issn = {1359-2998},
mesh = {Austria ; Chimera ; Genetics/*history ; History, 19th Century ; Hybridization, Genetic ; Peas/genetics/history ; },
abstract = {Gregor Mendel, an Augustinian monk and part-time school teacher, undertook a series of brilliant hybridisation experiments with garden peas between 1857 and 1864 in the monastery gardens and, using statistical methods for the first time in biology, established the laws of heredity, thereby establishing the discipline of genetics.},
}
MeSH Terms:
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hide MeSH Terms
Austria
Chimera
Genetics/*history
History, 19th Century
Hybridization, Genetic
Peas/genetics/history
RevDate: 2004-11-17
CmpDate: 2002-09-03
Postal stamps released on John Gregor Mendel (1822-1884).
The Journal of the Association of Physicians of India, 50:929.
Additional Links: PMID-12126349
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@article {pmid12126349,
year = {2002},
author = {Pai Dhungat, JV},
title = {Postal stamps released on John Gregor Mendel (1822-1884).},
journal = {The Journal of the Association of Physicians of India},
volume = {50},
number = {},
pages = {929},
pmid = {12126349},
issn = {0004-5772},
mesh = {Austria ; Czechoslovakia ; Genetics/history ; Germany, West ; History, 19th Century ; *Philately ; },
}
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Austria
Czechoslovakia
Genetics/history
Germany, West
History, 19th Century
*Philately
RevDate: 2010-11-18
CmpDate: 2002-06-27
Science in culture: peas without pictures--Gregor Mendel and the mathematical birth of modern genetics.
Nature, 417(6888):490.
Additional Links: PMID-12037544
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@article {pmid12037544,
year = {2002},
author = {Kemp, M},
title = {Science in culture: peas without pictures--Gregor Mendel and the mathematical birth of modern genetics.},
journal = {Nature},
volume = {417},
number = {6888},
pages = {490},
doi = {10.1038/417490a},
pmid = {12037544},
issn = {0028-0836},
mesh = {Austria ; Biological Evolution ; Books, Illustrated/history ; Culture ; Genetics/*history ; History, 19th Century ; Mathematics/*history ; Peas/genetics ; Science/history ; },
}
MeSH Terms:
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Austria
Biological Evolution
Books, Illustrated/history
Culture
Genetics/*history
History, 19th Century
Mathematics/*history
Peas/genetics
Science/history
RevDate: 2018-11-30
CmpDate: 2002-03-19
[Gregor Johann Mendel (1822-1884)].
Medicina, 61(6):903-904.
Additional Links: PMID-11808437
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@article {pmid11808437,
year = {2001},
author = {Zuckerberg, C},
title = {[Gregor Johann Mendel (1822-1884)].},
journal = {Medicina},
volume = {61},
number = {6},
pages = {903-904},
pmid = {11808437},
issn = {0025-7680},
mesh = {Austria ; Botany/*history ; Genetics/*history ; History, 19th Century ; Humans ; *Philately ; Vatican City ; },
}
MeSH Terms:
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Austria
Botany/*history
Genetics/*history
History, 19th Century
Humans
*Philately
Vatican City
RevDate: 2021-05-27
CmpDate: 2001-04-05
Gregor Johann Mendel.
Archives of pathology & laboratory medicine, 125(3):320-321.
Additional Links: PMID-11231475
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@article {pmid11231475,
year = {2001},
author = {Jay, V},
title = {Gregor Johann Mendel.},
journal = {Archives of pathology & laboratory medicine},
volume = {125},
number = {3},
pages = {320-321},
doi = {10.5858/2001-125-0320-GJM},
pmid = {11231475},
issn = {0003-9985},
mesh = {Austria ; Genetics/*history ; History, 19th Century ; },
}
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Austria
Genetics/*history
History, 19th Century
RevDate: 2019-11-04
CmpDate: 2001-02-15
Hugo De Vries: from the theory of intracellular pangenesis to the rediscovery of Mendel.
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 323(12):1053-1060.
On the basis of the article by the Dutch botanist Hugo De Vries 'On the law of separation of hybrids' published in the Reports of the Académie des Sciences in 1900, and the beginning of the controversy about priority with Carl Correns and Erich von Tschermak, I consider the question of the posthumous influence of the Mendel paper. I examine the construction of the new theoretical framework which enabled its reading in 1900 as a clear and acceptable presentation of the rules of the transmission of hereditary characters. In particular, I analyse the introduction of the idea of determinants of organic characters, understood as separable material elements which can be distributed randomly in descendants. Starting from the question of heredity, such as it was defined by Darwin in 1868, and after its critical developments by August Weismann, Hugo De Vries was able to suggest such an idea in his Intracellular Pangenesis. He then laid out a programme of research which helps us to understand the 'rediscovery' published in 1900.
Additional Links: PMID-11147091
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@article {pmid11147091,
year = {2000},
author = {Lenay, C},
title = {Hugo De Vries: from the theory of intracellular pangenesis to the rediscovery of Mendel.},
journal = {Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie},
volume = {323},
number = {12},
pages = {1053-1060},
doi = {10.1016/s0764-4469(00)01250-6},
pmid = {11147091},
issn = {0764-4469},
mesh = {Books ; Genetics/*history ; History, 19th Century ; History, 20th Century ; Plants/*genetics ; },
abstract = {On the basis of the article by the Dutch botanist Hugo De Vries 'On the law of separation of hybrids' published in the Reports of the Académie des Sciences in 1900, and the beginning of the controversy about priority with Carl Correns and Erich von Tschermak, I consider the question of the posthumous influence of the Mendel paper. I examine the construction of the new theoretical framework which enabled its reading in 1900 as a clear and acceptable presentation of the rules of the transmission of hereditary characters. In particular, I analyse the introduction of the idea of determinants of organic characters, understood as separable material elements which can be distributed randomly in descendants. Starting from the question of heredity, such as it was defined by Darwin in 1868, and after its critical developments by August Weismann, Hugo De Vries was able to suggest such an idea in his Intracellular Pangenesis. He then laid out a programme of research which helps us to understand the 'rediscovery' published in 1900.},
}
MeSH Terms:
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Books
Genetics/*history
History, 19th Century
History, 20th Century
Plants/*genetics
RevDate: 2018-11-30
CmpDate: 2000-12-28
MENDEL-BRNO 2000. Conference on DNA structure and interactions. Brno, Czech Republic, July 19-23, 2000. Abstracts.
Journal of biomolecular structure & dynamics, 17(6):1117-1183.
Additional Links: PMID-11126194
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@article {pmid11126194,
year = {2000},
author = {},
title = {MENDEL-BRNO 2000. Conference on DNA structure and interactions. Brno, Czech Republic, July 19-23, 2000. Abstracts.},
journal = {Journal of biomolecular structure & dynamics},
volume = {17},
number = {6},
pages = {1117-1183},
pmid = {11126194},
issn = {0739-1102},
mesh = {Animals ; *DNA/chemistry/drug effects ; Humans ; *Nucleic Acid Conformation ; Structure-Activity Relationship ; },
}
MeSH Terms:
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Animals
*DNA/chemistry/drug effects
Humans
*Nucleic Acid Conformation
Structure-Activity Relationship
RevDate: 2019-08-16
CmpDate: 1999-06-07
Genetic landmarks through philately--Gregor Johann Mendel (1822-1884).
Clinical genetics, 54(2):121-123.
Additional Links: PMID-9761389
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PubMed:
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@article {pmid9761389,
year = {1998},
author = {Chudley, AE},
title = {Genetic landmarks through philately--Gregor Johann Mendel (1822-1884).},
journal = {Clinical genetics},
volume = {54},
number = {2},
pages = {121-123},
doi = {10.1111/j.1399-0004.1998.tb03713.x},
pmid = {9761389},
issn = {0009-9163},
mesh = {Czech Republic ; Genetics/*history ; History, 19th Century ; Humans ; Male ; *Philately ; },
}
MeSH Terms:
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Czech Republic
Genetics/*history
History, 19th Century
Humans
Male
*Philately
RevDate: 2019-05-01
CmpDate: 1998-05-28
Gregor Johann Mendel (1822-84).
Journal of neurology, neurosurgery, and psychiatry, 64(5):587.
Additional Links: PMID-9598671
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@article {pmid9598671,
year = {1998},
author = {Haas, LF},
title = {Gregor Johann Mendel (1822-84).},
journal = {Journal of neurology, neurosurgery, and psychiatry},
volume = {64},
number = {5},
pages = {587},
doi = {10.1136/jnnp.64.5.587},
pmid = {9598671},
issn = {0022-3050},
mesh = {Austria ; Genetics/history ; History, 19th Century ; *Philately ; },
}
MeSH Terms:
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Austria
Genetics/history
History, 19th Century
*Philately
RevDate: 2019-05-16
CmpDate: 1998-02-27
Darwin and Mendel versus Watson and Crick.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 12(2):149-150.
Additional Links: PMID-9472979
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PubMed:
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@article {pmid9472979,
year = {1998},
author = {Pollack, R},
title = {Darwin and Mendel versus Watson and Crick.},
journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
volume = {12},
number = {2},
pages = {149-150},
doi = {10.1096/fasebj.12.2.149},
pmid = {9472979},
issn = {0892-6638},
mesh = {*Authorship ; *Biological Evolution ; DNA/chemistry/genetics ; *Genetic Code ; *Genetics ; *Periodicals as Topic ; },
}
MeSH Terms:
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*Authorship
*Biological Evolution
DNA/chemistry/genetics
*Genetic Code
*Genetics
*Periodicals as Topic
RevDate: 2007-11-15
CmpDate: 1997-11-19
Point of view: from Gregor Mendel to coronary atherosclerosis.
Medicine and health, Rhode Island, 80(10):348-350.
Additional Links: PMID-9350124
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@article {pmid9350124,
year = {1997},
author = {Corwin, RD},
title = {Point of view: from Gregor Mendel to coronary atherosclerosis.},
journal = {Medicine and health, Rhode Island},
volume = {80},
number = {10},
pages = {348-350},
pmid = {9350124},
issn = {1086-5462},
mesh = {Coronary Artery Disease/*genetics/*history ; History, 19th Century ; Humans ; },
}
MeSH Terms:
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Coronary Artery Disease/*genetics/*history
History, 19th Century
Humans
RevDate: 2018-11-13
CmpDate: 1995-03-20
Genetic mosaicism: what Gregor Mendel didn't know.
The Journal of clinical investigation, 95(2):443-444.
Additional Links: PMID-7860724
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@article {pmid7860724,
year = {1995},
author = {Hirschhorn, R},
title = {Genetic mosaicism: what Gregor Mendel didn't know.},
journal = {The Journal of clinical investigation},
volume = {95},
number = {2},
pages = {443-444},
pmid = {7860724},
issn = {0021-9738},
mesh = {DNA/genetics ; Female ; Humans ; Male ; Pedigree ; Severe Combined Immunodeficiency/*genetics ; *X Chromosome ; },
}
MeSH Terms:
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DNA/genetics
Female
Humans
Male
Pedigree
Severe Combined Immunodeficiency/*genetics
*X Chromosome
RevDate: 2018-11-30
CmpDate: 1995-03-06
International Congress on the Occasion of the 40th Anniversary of the Foundation of the Gregor Mendel Institute: Twin Study Today. Rome, Italy, 24-25 February 1994. Proceedings and abstracts.
Acta geneticae medicae et gemellologiae, 43(1-2):3-161.
Additional Links: PMID-7847020
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@article {pmid7847020,
year = {1994},
author = {},
title = {International Congress on the Occasion of the 40th Anniversary of the Foundation of the Gregor Mendel Institute: Twin Study Today. Rome, Italy, 24-25 February 1994. Proceedings and abstracts.},
journal = {Acta geneticae medicae et gemellologiae},
volume = {43},
number = {1-2},
pages = {3-161},
pmid = {7847020},
issn = {0001-5660},
mesh = {Humans ; *Twin Studies as Topic ; *Twins ; },
}
MeSH Terms:
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Humans
*Twin Studies as Topic
*Twins
RevDate: 2004-11-17
CmpDate: 1992-12-11
[Johann Gregor Mendel].
Deutsche medizinische Wochenschrift (1946), 117(45):1737-1738.
Additional Links: PMID-1425288
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@article {pmid1425288,
year = {1992},
author = {Riedel, M},
title = {[Johann Gregor Mendel].},
journal = {Deutsche medizinische Wochenschrift (1946)},
volume = {117},
number = {45},
pages = {1737-1738},
pmid = {1425288},
issn = {0012-0472},
mesh = {Austria ; Genetics/history ; History, 19th Century ; },
}
MeSH Terms:
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Austria
Genetics/history
History, 19th Century
RevDate: 2004-11-17
CmpDate: 1992-09-09
[Of flowering plants and garden peas. The first description of the laws of inheritance by Johann Gregor Mendel].
Deutsche medizinische Wochenschrift (1946), 117(31-32):1212-1216.
Additional Links: PMID-1644018
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@article {pmid1644018,
year = {1992},
author = {Kohl, F},
title = {[Of flowering plants and garden peas. The first description of the laws of inheritance by Johann Gregor Mendel].},
journal = {Deutsche medizinische Wochenschrift (1946)},
volume = {117},
number = {31-32},
pages = {1212-1216},
doi = {10.1055/s-0029-1235371},
pmid = {1644018},
issn = {0012-0472},
mesh = {Genetics/*history ; Germany ; History, 19th Century ; Plants/*genetics ; },
}
MeSH Terms:
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Genetics/*history
Germany
History, 19th Century
Plants/*genetics
RevDate: 2021-09-15
CmpDate: 1992-09-08
What did Gregor Mendel think he discovered?.
Genetics, 131(2):245-253.
Additional Links: PMID-1644269
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@article {pmid1644269,
year = {1992},
author = {Hartl, DL and Orel, V},
title = {What did Gregor Mendel think he discovered?.},
journal = {Genetics},
volume = {131},
number = {2},
pages = {245-253},
doi = {10.1093/genetics/131.2.245},
pmid = {1644269},
issn = {0016-6731},
mesh = {Crosses, Genetic ; Genetics/*history ; Germany ; History, 19th Century ; Hybridization, Genetic ; Plants/genetics ; Scientific Misconduct ; Statistics as Topic ; },
}
MeSH Terms:
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Crosses, Genetic
Genetics/*history
Germany
History, 19th Century
Hybridization, Genetic
Plants/genetics
Scientific Misconduct
Statistics as Topic
RevDate: 2009-05-27
CmpDate: 1993-02-11
[Mysteries surrounding Gregor Mendel and his research].
Nordisk medicinhistorisk arsbok.
Additional Links: PMID-11612933
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@article {pmid11612933,
year = {1992},
author = {Krook, H},
title = {[Mysteries surrounding Gregor Mendel and his research].},
journal = {Nordisk medicinhistorisk arsbok},
volume = {},
number = {},
pages = {69-82},
pmid = {11612933},
issn = {0303-6480},
mesh = {Austria ; Genetics/*history ; History, Modern 1601- ; },
}
MeSH Terms:
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Austria
Genetics/*history
History, Modern 1601-
RevDate: 2018-11-30
CmpDate: 1991-10-10
Historical study: Johann Gregor Mendel 1822-1884.
American journal of medical genetics, 40(1):1-25; discussion 26.
The life and personality of Johann Gregor Mendel (1822-1884), the founder of scientific genetics, are reviewed against the contemporary background of his times. At the end are weighed the benefits for Mendel (as charged by Sir Ronald Fisher) to have documented his results on hand of falsified data. Mendel was born into a humble farm family in the "Kuhländchen", then a predominantly German area of Northern Moravia. On the basis of great gifts Mendel was able to begin higher studies; however, he found himself in serious financial difficulties because of his father's accident and incapacitation. His hardships engendered illness which threatened continuation and completion of his studies until he was afforded the chance of absolving successfully theological studies as an Augustinian monk in the famous chapter of St. Thomas in Altbrünn (Staré Brno). Psychosomatic indisposition made Mendel unfit for practical pastoral duties. Thus, he was directed to teach but without appropriate state certification; an attempt to pass such an examination failed. At that point he was sent to the University of Vienna for a 2-year course of studies, with emphasis on physics and botany, to prepare him for the exam. His scientific and methodologic training enabled him to plan studies of the laws of inheritance, which had begun to interest him already during his theology training, and to choose the appropriate experimental plant. In 1865, after 12 years of systematic investigations on peas, he presented his results in the famous paper "Versuche über Pflanzenhybriden." Three years after his return from Vienna he failed to attain his teaching certification a second time. Only by virtue of his exceptional qualifications did he continue to function as a Supplementary Professor of Physics and Natural History in the two lowest classes of a secondary school. In 1868 he was elected Abbot of his chapter, and freed from teaching duties, was able to pursue his many scientific interests with greater efficiency. This included meteorology, the measurement of ground water levels, further hybridization in plants (a.o. involving the hawk week Hieracium up to about 1873), vegetable and fruit tree horticulture, apiculture, and agriculture in general. This involved Mendel's active participation in many organizations interested in advancing these fields at a time when appropriate research institutes did not exist in Brünn. Some of the positions he took in his capacity of Abbot had severe repercussions and further taxed Mendel's already over-stressed system. The worst of these was a 10-year confrontation with the government about the taxation of the monastery.(ABSTRACT TRUNCATED AT 400 WORDS)
Additional Links: PMID-1887835
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@article {pmid1887835,
year = {1991},
author = {Weiling, F},
title = {Historical study: Johann Gregor Mendel 1822-1884.},
journal = {American journal of medical genetics},
volume = {40},
number = {1},
pages = {1-25; discussion 26},
doi = {10.1002/ajmg.1320400103},
pmid = {1887835},
issn = {0148-7299},
mesh = {Austria ; Genetics/*history ; Germany ; History, 19th Century ; Mathematics/history ; },
abstract = {The life and personality of Johann Gregor Mendel (1822-1884), the founder of scientific genetics, are reviewed against the contemporary background of his times. At the end are weighed the benefits for Mendel (as charged by Sir Ronald Fisher) to have documented his results on hand of falsified data. Mendel was born into a humble farm family in the "Kuhländchen", then a predominantly German area of Northern Moravia. On the basis of great gifts Mendel was able to begin higher studies; however, he found himself in serious financial difficulties because of his father's accident and incapacitation. His hardships engendered illness which threatened continuation and completion of his studies until he was afforded the chance of absolving successfully theological studies as an Augustinian monk in the famous chapter of St. Thomas in Altbrünn (Staré Brno). Psychosomatic indisposition made Mendel unfit for practical pastoral duties. Thus, he was directed to teach but without appropriate state certification; an attempt to pass such an examination failed. At that point he was sent to the University of Vienna for a 2-year course of studies, with emphasis on physics and botany, to prepare him for the exam. His scientific and methodologic training enabled him to plan studies of the laws of inheritance, which had begun to interest him already during his theology training, and to choose the appropriate experimental plant. In 1865, after 12 years of systematic investigations on peas, he presented his results in the famous paper "Versuche über Pflanzenhybriden." Three years after his return from Vienna he failed to attain his teaching certification a second time. Only by virtue of his exceptional qualifications did he continue to function as a Supplementary Professor of Physics and Natural History in the two lowest classes of a secondary school. In 1868 he was elected Abbot of his chapter, and freed from teaching duties, was able to pursue his many scientific interests with greater efficiency. This included meteorology, the measurement of ground water levels, further hybridization in plants (a.o. involving the hawk week Hieracium up to about 1873), vegetable and fruit tree horticulture, apiculture, and agriculture in general. This involved Mendel's active participation in many organizations interested in advancing these fields at a time when appropriate research institutes did not exist in Brünn. Some of the positions he took in his capacity of Abbot had severe repercussions and further taxed Mendel's already over-stressed system. The worst of these was a 10-year confrontation with the government about the taxation of the monastery.(ABSTRACT TRUNCATED AT 400 WORDS)},
}
MeSH Terms:
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Austria
Genetics/*history
Germany
History, 19th Century
Mathematics/history
RevDate: 2007-11-15
CmpDate: 1995-06-09
Further medals with the portrait of Gregor Mendel.
Folia mendeliana, 26-27:103-106.
Four new medals with Mendel's portrait were issued after 1985. Two of them were issued by the Mendelianum in Brno, one comes from the Federal Republic of Germany, and one from Spain.
Additional Links: PMID-11640033
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@article {pmid11640033,
year = {1991},
author = {Obermajer, J},
title = {Further medals with the portrait of Gregor Mendel.},
journal = {Folia mendeliana},
volume = {26-27},
number = {},
pages = {103-106},
pmid = {11640033},
issn = {0085-0748},
mesh = {Genetics/*history ; History, 20th Century ; Humans ; Numismatics/*history ; Portraits as Topic/*history ; },
abstract = {Four new medals with Mendel's portrait were issued after 1985. Two of them were issued by the Mendelianum in Brno, one comes from the Federal Republic of Germany, and one from Spain.},
}
MeSH Terms:
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Genetics/*history
History, 20th Century
Humans
Numismatics/*history
Portraits as Topic/*history
RevDate: 2005-11-16
CmpDate: 1991-05-20
Fisher's contributions to genetics and heredity, with special emphasis on the Gregor Mendel controversy.
Biometrics, 46(4):915-924.
R. A. Fisher is widely respected for his contributions to both statistics and genetics. For instance, his 1930 text on The Genetical Theory of Natural Selection remains a watershed contribution in that area. Fisher's subsequent research led him to study the work of (Johann) Gregor Mendel, the 19th century monk who first developed the basic principles of heredity with experiments on garden peas. In examining Mendel's original 1865 article, Fisher noted that the conformity between Mendel's reported and proposed (theoretical) ratios of segregating individuals was unusually good, "too good" perhaps. The resulting controversy as to whether Mendel "cooked" his data for presentation has continued to the current day. This review highlights Fisher's most salient points as regards Mendel's "too good" fit, within the context of Fisher's extensive contributions to the development of genetical and evolutionary theory.
Additional Links: PMID-2085640
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@article {pmid2085640,
year = {1990},
author = {Piegorsch, WW},
title = {Fisher's contributions to genetics and heredity, with special emphasis on the Gregor Mendel controversy.},
journal = {Biometrics},
volume = {46},
number = {4},
pages = {915-924},
pmid = {2085640},
issn = {0006-341X},
mesh = {Animals ; Genes, Dominant ; Genes, Recessive ; *Genetics/history ; History, 19th Century ; History, 20th Century ; *Models, Genetic ; Plants/genetics ; },
abstract = {R. A. Fisher is widely respected for his contributions to both statistics and genetics. For instance, his 1930 text on The Genetical Theory of Natural Selection remains a watershed contribution in that area. Fisher's subsequent research led him to study the work of (Johann) Gregor Mendel, the 19th century monk who first developed the basic principles of heredity with experiments on garden peas. In examining Mendel's original 1865 article, Fisher noted that the conformity between Mendel's reported and proposed (theoretical) ratios of segregating individuals was unusually good, "too good" perhaps. The resulting controversy as to whether Mendel "cooked" his data for presentation has continued to the current day. This review highlights Fisher's most salient points as regards Mendel's "too good" fit, within the context of Fisher's extensive contributions to the development of genetical and evolutionary theory.},
}
MeSH Terms:
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Animals
Genes, Dominant
Genes, Recessive
*Genetics/history
History, 19th Century
History, 20th Century
*Models, Genetic
Plants/genetics
RevDate: 2006-11-15
CmpDate: 1989-06-13
[Gregor Mendel and dysplastic nevi].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 40(2):70-76.
In contrast to what has so far generally been believed, dysplastic nevi do not appear to be mendelizing, but rather due to polygenic inheritance. In order to explain this contrasting idea, the following six theses are presented: (1) All dysplastic nevi are inherited in the same manner. (2) Dysplastic nevi constitute a continuous trait. (3) A "dysplastic nevus syndrome" in the form of a monogenic autosomal dominant trait probably does not exist. (4) A nonhereditary dysplastic nevus syndrome does not exist. (5) The number of the underlying genes that, considered separately, do of course follow the rules of mendelian inheritance is so far unknown. (6) A search for a single underlying gene defect is probably hopeless.
Additional Links: PMID-2654075
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@article {pmid2654075,
year = {1989},
author = {Happle, R},
title = {[Gregor Mendel and dysplastic nevi].},
journal = {Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete},
volume = {40},
number = {2},
pages = {70-76},
pmid = {2654075},
issn = {0017-8470},
mesh = {Chromosome Mapping ; Dysplastic Nevus Syndrome/*genetics ; *Genetic Markers ; Humans ; Melanoma/genetics ; Skin Neoplasms/genetics ; },
abstract = {In contrast to what has so far generally been believed, dysplastic nevi do not appear to be mendelizing, but rather due to polygenic inheritance. In order to explain this contrasting idea, the following six theses are presented: (1) All dysplastic nevi are inherited in the same manner. (2) Dysplastic nevi constitute a continuous trait. (3) A "dysplastic nevus syndrome" in the form of a monogenic autosomal dominant trait probably does not exist. (4) A nonhereditary dysplastic nevus syndrome does not exist. (5) The number of the underlying genes that, considered separately, do of course follow the rules of mendelian inheritance is so far unknown. (6) A search for a single underlying gene defect is probably hopeless.},
}
MeSH Terms:
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Chromosome Mapping
Dysplastic Nevus Syndrome/*genetics
*Genetic Markers
Humans
Melanoma/genetics
Skin Neoplasms/genetics
RevDate: 2017-02-14
CmpDate: 1986-08-27
The Gregor Mendel controversy: early issues of goodness-of-fit and recent issues of genetic linkage.
History of science, 24(64 pt 2):173-182.
Additional Links: PMID-11611987
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@article {pmid11611987,
year = {1986},
author = {Piegorsch, WW},
title = {The Gregor Mendel controversy: early issues of goodness-of-fit and recent issues of genetic linkage.},
journal = {History of science},
volume = {24},
number = {64 pt 2},
pages = {173-182},
doi = {10.1177/007327538602400204},
pmid = {11611987},
issn = {0073-2753},
mesh = {Austria ; Genetics/*history ; History, Modern 1601- ; },
}
MeSH Terms:
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Austria
Genetics/*history
History, Modern 1601-
RevDate: 2019-05-10
CmpDate: 1986-09-16
A solution to the too-good-to-be-true paradox and Gregor Mendel.
The Journal of heredity, 77(3):218-220.
Additional Links: PMID-3734409
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@article {pmid3734409,
year = {1986},
author = {Pilgrim, I},
title = {A solution to the too-good-to-be-true paradox and Gregor Mendel.},
journal = {The Journal of heredity},
volume = {77},
number = {3},
pages = {218-220},
doi = {10.1093/oxfordjournals.jhered.a110224},
pmid = {3734409},
issn = {0022-1503},
mesh = {Female ; Genetics, Medical ; Humans ; Male ; *Models, Genetic ; Probability ; Sex Ratio ; },
}
MeSH Terms:
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Female
Genetics, Medical
Humans
Male
*Models, Genetic
Probability
Sex Ratio
RevDate: 2018-11-30
CmpDate: 1985-06-25
[Centenary of the death of Gregor Mendel].
Gaceta medica de Mexico, 121(3-4):107-134.
Additional Links: PMID-3888763
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@article {pmid3888763,
year = {1985},
author = {Márquez-Montez, H and Salamanca Gómez, F and Urzúa, R and Velázquez, A and Cantú, },
title = {[Centenary of the death of Gregor Mendel].},
journal = {Gaceta medica de Mexico},
volume = {121},
number = {3-4},
pages = {107-134},
pmid = {3888763},
issn = {0016-3813},
mesh = {Austria ; Genetics/history ; History, 19th Century ; },
}
MeSH Terms:
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Austria
Genetics/history
History, 19th Century
RevDate: 2019-09-19
CmpDate: 1986-05-21
Gregor Mendel and twins.
Acta geneticae medicae et gemellologiae, 34(3-4):121-124.
Additional Links: PMID-3914164
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PubMed:
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@article {pmid3914164,
year = {1985},
author = {Gedda, L and Parisi, P},
title = {Gregor Mendel and twins.},
journal = {Acta geneticae medicae et gemellologiae},
volume = {34},
number = {3-4},
pages = {121-124},
doi = {10.1017/s0001566000004645},
pmid = {3914164},
issn = {0001-5660},
mesh = {Austria ; History, 18th Century ; History, 19th Century ; History, 20th Century ; Humans ; Pedigree ; *Twins ; },
}
MeSH Terms:
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Austria
History, 18th Century
History, 19th Century
History, 20th Century
Humans
Pedigree
*Twins
RevDate: 2018-11-30
CmpDate: 1985-10-23
[Johann Gregor Mendel and medical genetics. A medical history sketch on the occasion of the 100th anniversary of his death 6 January 1984].
Zeitschrift fur arztliche Fortbildung, 79(12):543-546.
Additional Links: PMID-3898613
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@article {pmid3898613,
year = {1985},
author = {Pelz, L},
title = {[Johann Gregor Mendel and medical genetics. A medical history sketch on the occasion of the 100th anniversary of his death 6 January 1984].},
journal = {Zeitschrift fur arztliche Fortbildung},
volume = {79},
number = {12},
pages = {543-546},
pmid = {3898613},
issn = {0044-2178},
mesh = {Austria ; Genetics, Medical/history ; History, 19th Century ; },
}
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Austria
Genetics, Medical/history
History, 19th Century
RevDate: 2019-05-11
CmpDate: 1985-05-08
Mendel, the empiricist.
The Journal of heredity, 76(1):49-54.
In contemporary texts in biology and genetics, Mendel is frequently portrayed as a theorist who was the father of classical genetics. According to some authors, he created his theory of inheritance to explain the results of his experimental hybridizations of peas. Others have proposed that he designed and carried out his experiments to demonstrate the correctness of a theory of inheritance he had already developed. We disagree strongly with these views of Mendel. Instead, we have come to regard him as an empirical investigator trying to discover the empirical natural laws describing the formation of hybrid peas and the development of their offspring over several generations. We have supported our view with an analysis of portions of Mendel's paper and his letters to Carl N ageli.
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@article {pmid3884699,
year = {1985},
author = {Monaghan, FV and Corcos, AF},
title = {Mendel, the empiricist.},
journal = {The Journal of heredity},
volume = {76},
number = {1},
pages = {49-54},
doi = {10.1093/oxfordjournals.jhered.a110017},
pmid = {3884699},
issn = {0022-1503},
mesh = {Genetics/*history ; History, 19th Century ; },
abstract = {In contemporary texts in biology and genetics, Mendel is frequently portrayed as a theorist who was the father of classical genetics. According to some authors, he created his theory of inheritance to explain the results of his experimental hybridizations of peas. Others have proposed that he designed and carried out his experiments to demonstrate the correctness of a theory of inheritance he had already developed. We disagree strongly with these views of Mendel. Instead, we have come to regard him as an empirical investigator trying to discover the empirical natural laws describing the formation of hybrid peas and the development of their offspring over several generations. We have supported our view with an analysis of portions of Mendel's paper and his letters to Carl N ageli.},
}
MeSH Terms:
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Genetics/*history
History, 19th Century
RevDate: 2019-05-11
CmpDate: 1985-02-04
The too-good-to-be-true paradox and Gregor Mendel.
The Journal of heredity, 75(6):501-502.
Additional Links: PMID-6392413
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@article {pmid6392413,
year = {1984},
author = {Pilgrim, I},
title = {The too-good-to-be-true paradox and Gregor Mendel.},
journal = {The Journal of heredity},
volume = {75},
number = {6},
pages = {501-502},
doi = {10.1093/oxfordjournals.jhered.a109998},
pmid = {6392413},
issn = {0022-1503},
mesh = {Austria ; Fraud ; Genetics/*history ; History, 19th Century ; Probability ; Research Design ; },
}
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Austria
Fraud
Genetics/*history
History, 19th Century
Probability
Research Design
RevDate: 2019-05-11
CmpDate: 1985-02-04
L. H. Bailey's citations to Gregor Mendel.
The Journal of heredity, 75(6):500-501.
L. H. Bailey cited Mendel's 1865 and 1869 papers in the bibliography that accompanied his 1892 paper, Cross-Breeding and Hybridizing, and Mendel is mentioned once in the 1895 edition of Bailey's "Plant-Breeding." Bailey claimed to have copied his 1892 references to Mendel from Focke. It seems, however, that while he may have first encountered references to Mendel's work in Focke, he actually copied them from the Royal Society "Catalogue of Scientific Papers." Bailey also saw a reference to Mendel's 1865 paper in Jackson's "Guide to the Literature of Botany." Bailey's 1895 mention of Mendel occurs in a passage he translated from Focke's "Die Pflanzen-Mischlinge."
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@article {pmid6392412,
year = {1984},
author = {MacRoberts, MH},
title = {L. H. Bailey's citations to Gregor Mendel.},
journal = {The Journal of heredity},
volume = {75},
number = {6},
pages = {500-501},
doi = {10.1093/oxfordjournals.jhered.a109997},
pmid = {6392412},
issn = {0022-1503},
mesh = {Austria ; Genetics/*history ; History, 19th Century ; United States ; },
abstract = {L. H. Bailey cited Mendel's 1865 and 1869 papers in the bibliography that accompanied his 1892 paper, Cross-Breeding and Hybridizing, and Mendel is mentioned once in the 1895 edition of Bailey's "Plant-Breeding." Bailey claimed to have copied his 1892 references to Mendel from Focke. It seems, however, that while he may have first encountered references to Mendel's work in Focke, he actually copied them from the Royal Society "Catalogue of Scientific Papers." Bailey also saw a reference to Mendel's 1865 paper in Jackson's "Guide to the Literature of Botany." Bailey's 1895 mention of Mendel occurs in a passage he translated from Focke's "Die Pflanzen-Mischlinge."},
}
MeSH Terms:
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Austria
Genetics/*history
History, 19th Century
United States
RevDate: 2020-08-24
CmpDate: 1984-07-19
Gregor Mendel and the people around him (commemorative of the centennial of Mendel's death).
American journal of human genetics, 36(3):495-498.
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@article {pmid6375354,
year = {1984},
author = {Soudek, D},
title = {Gregor Mendel and the people around him (commemorative of the centennial of Mendel's death).},
journal = {American journal of human genetics},
volume = {36},
number = {3},
pages = {495-498},
pmid = {6375354},
issn = {0002-9297},
mesh = {Austria ; Genetics/history ; History, 19th Century ; },
}
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Austria
Genetics/history
History, 19th Century
RevDate: 2015-03-05
CmpDate: 1984-06-12
[Gregor Mendel (1822-1884)].
Rivista di biologia, 77(1):105-113.
Additional Links: PMID-6372053
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@article {pmid6372053,
year = {1984},
author = {Sermonti, G},
title = {[Gregor Mendel (1822-1884)].},
journal = {Rivista di biologia},
volume = {77},
number = {1},
pages = {105-113},
pmid = {6372053},
issn = {0035-6050},
mesh = {Austria ; Genetics/*history ; History, 19th Century ; Plants/genetics ; },
}
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Austria
Genetics/*history
History, 19th Century
Plants/genetics
RevDate: 2019-10-31
CmpDate: 1984-06-13
Gregor Mendel: founding-father of modern genetics?.
Endeavour, 8(1):29-31.
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@article {pmid6201345,
year = {1984},
author = {Oldroyd, D},
title = {Gregor Mendel: founding-father of modern genetics?.},
journal = {Endeavour},
volume = {8},
number = {1},
pages = {29-31},
doi = {10.1016/0160-9327(84)90126-1},
pmid = {6201345},
issn = {0160-9327},
mesh = {Austria ; Genetics/*history ; History, 19th Century ; Plants/genetics ; },
}
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Austria
Genetics/*history
History, 19th Century
Plants/genetics
RevDate: 2018-11-30
CmpDate: 1984-06-27
Gregor Johann Mendel 1822-1884. In centenary commemoration.
Hereditas, 100(1):II-XIII.
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@article {pmid6144644,
year = {1984},
author = {},
title = {Gregor Johann Mendel 1822-1884. In centenary commemoration.},
journal = {Hereditas},
volume = {100},
number = {1},
pages = {II-XIII},
pmid = {6144644},
issn = {0018-0661},
mesh = {Austria ; Congresses as Topic/history ; Genetics/history ; History, 19th Century ; Manuscripts as Topic ; Plants/genetics ; },
}
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Austria
Congresses as Topic/history
Genetics/history
History, 19th Century
Manuscripts as Topic
Plants/genetics
RevDate: 2013-12-13
CmpDate: 1977-09-17
Gregor Johann Mendel and the beginning of genetics.
Mayo Clinic proceedings, 52(8):513-518.
Additional Links: PMID-329015
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@article {pmid329015,
year = {1977},
author = {Dewald, GW},
title = {Gregor Johann Mendel and the beginning of genetics.},
journal = {Mayo Clinic proceedings},
volume = {52},
number = {8},
pages = {513-518},
pmid = {329015},
issn = {0025-6196},
mesh = {Austria ; Genetics/*history ; History, 19th Century ; },
}
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Austria
Genetics/*history
History, 19th Century
RevDate: 2019-06-17
CmpDate: 1975-10-21
Why didn't Gregor Mendel find linkage?.
Nature, 256(5514):206.
Additional Links: PMID-1097939
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@article {pmid1097939,
year = {1975},
author = {Blixt, S},
title = {Why didn't Gregor Mendel find linkage?.},
journal = {Nature},
volume = {256},
number = {5514},
pages = {206},
doi = {10.1038/256206a0},
pmid = {1097939},
issn = {0028-0836},
mesh = {Alleles ; Chromosome Mapping ; *Genetic Linkage ; Genetics/history ; History, 19th Century ; },
}
MeSH Terms:
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Alleles
Chromosome Mapping
*Genetic Linkage
Genetics/history
History, 19th Century
RevDate: 2019-05-11
CmpDate: 1973-06-21
Interest in hybridization in Moravia before Mendel came to Brno.
The Journal of heredity, 64(1):51-52.
Additional Links: PMID-4572928
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@article {pmid4572928,
year = {1973},
author = {Orel, V},
title = {Interest in hybridization in Moravia before Mendel came to Brno.},
journal = {The Journal of heredity},
volume = {64},
number = {1},
pages = {51-52},
doi = {10.1093/oxfordjournals.jhered.a108342},
pmid = {4572928},
issn = {0022-1503},
mesh = {Czechoslovakia ; *Famous Persons ; Genetics/*history ; History, 19th Century ; *Hybridization, Genetic ; },
}
MeSH Terms:
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Czechoslovakia
*Famous Persons
Genetics/*history
History, 19th Century
*Hybridization, Genetic
RevDate: 2009-10-21
CmpDate: 1972-11-18
[Johann Gregor Mendel, founder of modern genetics (1822-1884)].
Orvosi hetilap, 113(42):2539-2541.
Additional Links: PMID-4561361
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@article {pmid4561361,
year = {1972},
author = {Kenéz, J},
title = {[Johann Gregor Mendel, founder of modern genetics (1822-1884)].},
journal = {Orvosi hetilap},
volume = {113},
number = {42},
pages = {2539-2541},
pmid = {4561361},
issn = {0030-6002},
mesh = {Austria ; Czechoslovakia ; Genetics/*history ; History, 19th Century ; },
}
MeSH Terms:
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Austria
Czechoslovakia
Genetics/*history
History, 19th Century
RevDate: 2004-11-17
CmpDate: 1971-05-05
[Gregor Mendel and the animal breeding in Moravia].
Schweizer Archiv fur Tierheilkunde, 113(2):82-83.
Additional Links: PMID-4927109
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@article {pmid4927109,
year = {1971},
author = {Orel, V},
title = {[Gregor Mendel and the animal breeding in Moravia].},
journal = {Schweizer Archiv fur Tierheilkunde},
volume = {113},
number = {2},
pages = {82-83},
pmid = {4927109},
issn = {0036-7281},
mesh = {Animal Population Groups/classification ; Animals ; Breeding/*history ; Czechoslovakia ; Genetics/*history ; History, 19th Century ; },
}
MeSH Terms:
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Animal Population Groups/classification
Animals
Breeding/*history
Czechoslovakia
Genetics/*history
History, 19th Century
RevDate: 2010-06-28
CmpDate: 2010-06-28
Gregor Johann mendel.
Canadian Medical Association journal, 102(9):987.
Additional Links: PMID-20311624
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@article {pmid20311624,
year = {1970},
author = {Perl, AF},
title = {Gregor Johann mendel.},
journal = {Canadian Medical Association journal},
volume = {102},
number = {9},
pages = {987},
pmid = {20311624},
issn = {0008-4409},
}
RevDate: 2019-06-06
CmpDate: 1971-02-04
The life of Gregor Johann Mendel--tragic or not?.
Hereditas, 62(1):239-258.
Additional Links: PMID-4922561
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@article {pmid4922561,
year = {1969},
author = {Gustafsson, A},
title = {The life of Gregor Johann Mendel--tragic or not?.},
journal = {Hereditas},
volume = {62},
number = {1},
pages = {239-258},
doi = {10.1111/j.1601-5223.1969.tb02232.x},
pmid = {4922561},
issn = {0018-0661},
mesh = {Austria ; *Famous Persons ; Genetics/*history ; History, 19th Century ; },
}
MeSH Terms:
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Austria
*Famous Persons
Genetics/*history
History, 19th Century
RevDate: 2019-07-04
CmpDate: 1966-10-15
Gregor Johann Mendel on Pisum sativum. A centennial.
Archives of ophthalmology (Chicago, Ill. : 1960), 76(2):287-289.
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@article {pmid5329496,
year = {1966},
author = {Mark, HH},
title = {Gregor Johann Mendel on Pisum sativum. A centennial.},
journal = {Archives of ophthalmology (Chicago, Ill. : 1960)},
volume = {76},
number = {2},
pages = {287-289},
doi = {10.1001/archopht.1966.03850010289022},
pmid = {5329496},
issn = {0003-9950},
mesh = {Czechoslovakia ; Genetics/*history ; History, 19th Century ; },
}
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Czechoslovakia
Genetics/*history
History, 19th Century
RevDate: 2008-02-13
CmpDate: 1967-08-05
[Gregor Mendel--the founder of genetics].
Izvestiia Akademii nauk SSSR. Seriia biologicheskaia, 6:809-824.
Additional Links: PMID-5338340
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@article {pmid5338340,
year = {1965},
author = {Dubinin, NP},
title = {[Gregor Mendel--the founder of genetics].},
journal = {Izvestiia Akademii nauk SSSR. Seriia biologicheskaia},
volume = {6},
number = {},
pages = {809-824},
pmid = {5338340},
issn = {0002-3329},
mesh = {Austria ; Genetics/*history ; *History, 19th Century ; },
}
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Austria
Genetics/*history
*History, 19th Century
RevDate: 2004-11-17
CmpDate: 1967-07-22
[Johann Gregor Mendel].
Tsitologiia, 7(6):701-703.
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@article {pmid5337880,
year = {1965},
author = {Vakhtin, IuB},
title = {[Johann Gregor Mendel].},
journal = {Tsitologiia},
volume = {7},
number = {6},
pages = {701-703},
pmid = {5337880},
issn = {0041-3771},
mesh = {Austria ; Biology/*history ; History, 19th Century ; },
}
MeSH Terms:
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Austria
Biology/*history
History, 19th Century
RevDate: 2014-09-12
CmpDate: 1966-03-18
[Gregor Johnann Mendel (1822-1884) the founder of the science of genetics].
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 39(36):827-828.
Additional Links: PMID-5322527
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@article {pmid5322527,
year = {1965},
author = {Steytler, JG},
title = {[Gregor Johnann Mendel (1822-1884) the founder of the science of genetics].},
journal = {South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde},
volume = {39},
number = {36},
pages = {827-828},
pmid = {5322527},
issn = {0256-9574},
mesh = {Genetics/*history ; History, 19th Century ; },
}
MeSH Terms:
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Genetics/*history
History, 19th Century
RevDate: 2006-04-12
CmpDate: 1966-12-31
[On the scientific heritage of Gregor Mendel].
Zhurnal obshchei biologii, 26(5):521-527.
Additional Links: PMID-5331606
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@article {pmid5331606,
year = {1965},
author = {Astaurov, BL},
title = {[On the scientific heritage of Gregor Mendel].},
journal = {Zhurnal obshchei biologii},
volume = {26},
number = {5},
pages = {521-527},
pmid = {5331606},
issn = {0044-4596},
mesh = {Austria ; Genetics/*history ; History, 19th Century ; },
}
MeSH Terms:
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Austria
Genetics/*history
History, 19th Century
RevDate: 2004-11-17
CmpDate: 1966-03-12
[The fatal disease of Gregor Mendel].
Vnitrni lekarstvi, 11(9):909-916.
Additional Links: PMID-5322351
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@article {pmid5322351,
year = {1965},
author = {Sajner, J},
title = {[The fatal disease of Gregor Mendel].},
journal = {Vnitrni lekarstvi},
volume = {11},
number = {9},
pages = {909-916},
pmid = {5322351},
issn = {0042-773X},
mesh = {Genetics/*history ; History, 19th Century ; },
}
MeSH Terms:
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Genetics/*history
History, 19th Century
RevDate: 2010-11-18
CmpDate: 1968-11-20
[Centenary of the publication of the works of Gregor Mendel on genetics. V. Mendelism and biological evolution].
Gaceta medica de Mexico, 95(9):815-825.
Additional Links: PMID-4878292
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@article {pmid4878292,
year = {1965},
author = {Ondarza, RN},
title = {[Centenary of the publication of the works of Gregor Mendel on genetics. V. Mendelism and biological evolution].},
journal = {Gaceta medica de Mexico},
volume = {95},
number = {9},
pages = {815-825},
pmid = {4878292},
issn = {0016-3813},
mesh = {Biological Evolution/*history ; *Famous Persons ; Genetics/*history ; History of Medicine ; History, 19th Century ; History, 20th Century ; },
}
MeSH Terms:
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Biological Evolution/*history
*Famous Persons
Genetics/*history
History of Medicine
History, 19th Century
History, 20th Century
RevDate: 2009-11-11
CmpDate: 1968-11-20
[Centenary of the publication of the works of Gregor Mendel on genetics. 3. The laws of heredity and human pathology].
Gaceta medica de Mexico, 95(9):795-806.
Additional Links: PMID-4878290
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@article {pmid4878290,
year = {1965},
author = {Salazar Mallén, M},
title = {[Centenary of the publication of the works of Gregor Mendel on genetics. 3. The laws of heredity and human pathology].},
journal = {Gaceta medica de Mexico},
volume = {95},
number = {9},
pages = {795-806},
pmid = {4878290},
issn = {0016-3813},
mesh = {*Famous Persons ; Genetic Diseases, Inborn/*history ; Genetics/*history ; History of Medicine ; History, 19th Century ; History, 20th Century ; },
}
MeSH Terms:
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*Famous Persons
Genetic Diseases, Inborn/*history
Genetics/*history
History of Medicine
History, 19th Century
History, 20th Century
RevDate: 2009-11-11
CmpDate: 1968-11-20
[Centenary of the publication of the works of Gregor Mendel on genetics. II. The abbot Gregor Mendel and his era].
Gaceta medica de Mexico, 95(9):781-794.
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@article {pmid4878289,
year = {1965},
author = {Somolinos D'Ardois, G},
title = {[Centenary of the publication of the works of Gregor Mendel on genetics. II. The abbot Gregor Mendel and his era].},
journal = {Gaceta medica de Mexico},
volume = {95},
number = {9},
pages = {781-794},
pmid = {4878289},
issn = {0016-3813},
mesh = {*Famous Persons ; Genetics/*history ; History of Medicine ; History, 19th Century ; },
}
MeSH Terms:
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*Famous Persons
Genetics/*history
History of Medicine
History, 19th Century
RevDate: 2009-11-11
CmpDate: 1968-11-20
[Centenary of the publication of the works of Gregor Mendel on genetics. I. Introduction].
Gaceta medica de Mexico, 95(9):777-779.
Additional Links: PMID-4878288
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@article {pmid4878288,
year = {1965},
author = {Salazar Mallén, M},
title = {[Centenary of the publication of the works of Gregor Mendel on genetics. I. Introduction].},
journal = {Gaceta medica de Mexico},
volume = {95},
number = {9},
pages = {777-779},
pmid = {4878288},
issn = {0016-3813},
mesh = {*Famous Persons ; Genetics/*history ; History of Medicine ; History, 19th Century ; },
}
MeSH Terms:
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*Famous Persons
Genetics/*history
History of Medicine
History, 19th Century
RevDate: 2004-11-17
CmpDate: 1967-01-23
[Gregor Johann Mendel].
Mikrobiologiia, 34(4):733-739.
Additional Links: PMID-5332142
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@article {pmid5332142,
year = {1965},
author = {Alikhanian, SI},
title = {[Gregor Johann Mendel].},
journal = {Mikrobiologiia},
volume = {34},
number = {4},
pages = {733-739},
pmid = {5332142},
issn = {0026-3656},
mesh = {Austria ; Botany/*history ; Genetics/*history ; History, 19th Century ; },
}
MeSH Terms:
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Austria
Botany/*history
Genetics/*history
History, 19th Century
RevDate: 2014-04-06
CmpDate: 1966-10-08
[Gregor Mendel--founder of the science of heredity. (On the centenary of the foundation of experimental genetics)].
Veterinariia, 42(7):112-113.
Additional Links: PMID-5328933
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@article {pmid5328933,
year = {1965},
author = {Tiniakov, GG},
title = {[Gregor Mendel--founder of the science of heredity. (On the centenary of the foundation of experimental genetics)].},
journal = {Veterinariia},
volume = {42},
number = {7},
pages = {112-113},
pmid = {5328933},
issn = {0042-4846},
mesh = {Genetics/*history ; History, 19th Century ; USSR ; },
}
MeSH Terms:
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Genetics/*history
History, 19th Century
USSR
RevDate: 2004-11-17
CmpDate: 1966-02-05
[The abbot Gregor Johann Mendel].
Medicina, 45(964):73-74.
Additional Links: PMID-5321014
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@article {pmid5321014,
year = {1965},
author = {Saavedra, AM},
title = {[The abbot Gregor Johann Mendel].},
journal = {Medicina},
volume = {45},
number = {964},
pages = {73-74},
pmid = {5321014},
issn = {0025-7702},
mesh = {Genetics/history ; History, 19th Century ; },
}
MeSH Terms:
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Genetics/history
History, 19th Century
RevDate: 2019-05-01
CmpDate: 1996-12-01
GREGOR MENDEL.
British medical journal, 1(5431):333-338.
Additional Links: PMID-14237897
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@article {pmid14237897,
year = {1965},
author = {SORSBY, A},
title = {GREGOR MENDEL.},
journal = {British medical journal},
volume = {1},
number = {5431},
pages = {333-338},
doi = {10.1136/bmj.1.5431.333},
pmid = {14237897},
issn = {0007-1447},
mesh = {Austria ; Czechoslovakia ; *Genetics ; *Genetics, Medical ; History, 19th Century ; *Medicine ; },
}
MeSH Terms:
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Austria
Czechoslovakia
*Genetics
*Genetics, Medical
History, 19th Century
*Medicine
RevDate: 2004-11-17
CmpDate: 1968-05-23
[Gregor Mendel, the classic Mendelism and its influence on human genetics].
Archiv der Julius Klaus-Stiftung fur Vererbungsforschung, Sozialanthropologie und Rassenhygiene, 40(1-4):9-18.
Additional Links: PMID-4868655
PubMed:
Citation:
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@article {pmid4868655,
year = {1965},
author = {Klein, D},
title = {[Gregor Mendel, the classic Mendelism and its influence on human genetics].},
journal = {Archiv der Julius Klaus-Stiftung fur Vererbungsforschung, Sozialanthropologie und Rassenhygiene},
volume = {40},
number = {1-4},
pages = {9-18},
pmid = {4868655},
issn = {0003-8881},
mesh = {Austria ; Genetics, Medical/*history ; History, 19th Century ; },
}
MeSH Terms:
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Austria
Genetics, Medical/*history
History, 19th Century
RevDate: 2018-12-01
CmpDate: 1996-12-01
GREGOR JOHANN MENDEL--GENETICIST.
The New physician, 13:A88-A89.
Additional Links: PMID-14122816
PubMed:
Citation:
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@article {pmid14122816,
year = {1964},
author = {BARNETT, CF},
title = {GREGOR JOHANN MENDEL--GENETICIST.},
journal = {The New physician},
volume = {13},
number = {},
pages = {A88-A89},
pmid = {14122816},
issn = {0028-6451},
mesh = {*Genetics ; *History, 19th Century ; *Physicians ; },
}
MeSH Terms:
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*Genetics
*History, 19th Century
*Physicians
RevDate: 2018-12-01
CmpDate: 1998-11-01
[Founding of the Gregor Mendel Department of Genetics in the Moravian Museum in Brno and its museum and research program].
Biologia, 17:907-911.
Additional Links: PMID-14035880
PubMed:
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@article {pmid14035880,
year = {1962},
author = {KRIZENECKY, J},
title = {[Founding of the Gregor Mendel Department of Genetics in the Moravian Museum in Brno and its museum and research program].},
journal = {Biologia},
volume = {17},
number = {},
pages = {907-911},
pmid = {14035880},
issn = {0006-3088},
mesh = {*Genetics ; Humans ; *Museums ; },
}
MeSH Terms:
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*Genetics
Humans
*Museums
RevDate: 2018-12-01
CmpDate: 1998-11-01
[The discovery and rediscovery of the laws of heredity. (The work of Johann Gregor Mendel)].
Revista. Asociacion Medica Mexicana, 40:401-410.
Additional Links: PMID-13769416
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@article {pmid13769416,
year = {1960},
author = {MENESES HOYOS, J},
title = {[The discovery and rediscovery of the laws of heredity. (The work of Johann Gregor Mendel)].},
journal = {Revista. Asociacion Medica Mexicana},
volume = {40},
number = {},
pages = {401-410},
pmid = {13769416},
mesh = {Genetics/*history ; *Heredity ; Humans ; *Work ; },
}
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Genetics/*history
*Heredity
Humans
*Work
RevDate: 2019-06-05
CmpDate: 1998-11-01
A note on the bibliography of Gregor Mendel.
Medical history, 3:331-333.
Additional Links: PMID-13841025
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@article {pmid13841025,
year = {1959},
author = {VAN DER PAS, PW},
title = {A note on the bibliography of Gregor Mendel.},
journal = {Medical history},
volume = {3},
number = {},
pages = {331-333},
doi = {10.1017/s002572730002487x},
pmid = {13841025},
issn = {0025-7273},
mesh = {*Genetics ; Humans ; },
}
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*Genetics
Humans
RevDate: 2019-06-05
CmpDate: 2000-07-01
Darwin, Mendel, and Galton.
Medical history, 3(2):87-99.
Additional Links: PMID-13643143
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@article {pmid13643143,
year = {1959},
author = {PLATT, R},
title = {Darwin, Mendel, and Galton.},
journal = {Medical history},
volume = {3},
number = {2},
pages = {87-99},
doi = {10.1017/s0025727300024376},
pmid = {13643143},
issn = {0025-7273},
mesh = {*Heredity ; *History, 19th Century ; *History, 20th Century ; },
}
MeSH Terms:
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*Heredity
*History, 19th Century
*History, 20th Century
RevDate: 2019-11-08
CmpDate: 2004-02-15
Gregor Mendel & his precursors.
Isis; an international review devoted to the history of science and its cultural influences, 42(128):97-104.
Additional Links: PMID-14840950
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@article {pmid14840950,
year = {1951},
author = {ZIRKLE, C},
title = {Gregor Mendel & his precursors.},
journal = {Isis; an international review devoted to the history of science and its cultural influences},
volume = {42},
number = {128},
pages = {97-104},
doi = {10.1086/349277},
pmid = {14840950},
issn = {0021-1753},
mesh = {*Botany ; History, 19th Century ; },
}
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*Botany
History, 19th Century
RevDate: 2020-10-05
CmpDate: 2010-03-18
A note about the fundamental work of Gregor Mendel.
Comptes rendus des seances de la Societe de biologie et de ses filiales, 141(3-4):182.
Additional Links: PMID-20268996
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@article {pmid20268996,
year = {1947},
author = {LIENHART, R},
title = {A note about the fundamental work of Gregor Mendel.},
journal = {Comptes rendus des seances de la Societe de biologie et de ses filiales},
volume = {141},
number = {3-4},
pages = {182},
pmid = {20268996},
issn = {0037-9026},
mesh = {Humans ; },
}
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Humans
RevDate: 2010-06-10
CmpDate: 2010-07-02
GREGOR MENDEL.
Science (New York, N.Y.), 70(1801):16.
Additional Links: PMID-17802048
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@article {pmid17802048,
year = {1929},
author = {Davenport, CB},
title = {GREGOR MENDEL.},
journal = {Science (New York, N.Y.)},
volume = {70},
number = {1801},
pages = {16},
doi = {10.1126/science.70.1801.16},
pmid = {17802048},
issn = {0036-8075},
}
RevDate: 2010-06-10
CmpDate: 2010-07-02
GREGOR MENDEL AND THE SUPPORT OF SCIENTIFIC WORK AT BRUNN.
Science (New York, N.Y.), 54(1395):275-276.
Additional Links: PMID-17787123
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@article {pmid17787123,
year = {1921},
author = {Babcock, EB},
title = {GREGOR MENDEL AND THE SUPPORT OF SCIENTIFIC WORK AT BRUNN.},
journal = {Science (New York, N.Y.)},
volume = {54},
number = {1395},
pages = {275-276},
doi = {10.1126/science.54.1395.275-a},
pmid = {17787123},
issn = {0036-8075},
}
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ESP Quick Facts
ESP Origins
In the early 1990's, Robert Robbins was a faculty member at Johns Hopkins, where he directed the informatics core of GDB — the human gene-mapping database of the international human genome project. To share papers with colleagues around the world, he set up a small paper-sharing section on his personal web page. This small project evolved into The Electronic Scholarly Publishing Project.
ESP Support
In 1995, Robbins became the VP/IT of the Fred Hutchinson Cancer Research Center in Seattle, WA. Soon after arriving in Seattle, Robbins secured funding, through the ELSI component of the US Human Genome Project, to create the original ESP.ORG web site, with the formal goal of providing free, world-wide access to the literature of classical genetics.
ESP Rationale
Although the methods of molecular biology can seem almost magical to the uninitiated, the original techniques of classical genetics are readily appreciated by one and all: cross individuals that differ in some inherited trait, collect all of the progeny, score their attributes, and propose mechanisms to explain the patterns of inheritance observed.
ESP Goal
In reading the early works of classical genetics, one is drawn, almost inexorably, into ever more complex models, until molecular explanations begin to seem both necessary and natural. At that point, the tools for understanding genome research are at hand. Assisting readers reach this point was the original goal of The Electronic Scholarly Publishing Project.
ESP Usage
Usage of the site grew rapidly and has remained high. Faculty began to use the site for their assigned readings. Other on-line publishers, ranging from The New York Times to Nature referenced ESP materials in their own publications. Nobel laureates (e.g., Joshua Lederberg) regularly used the site and even wrote to suggest changes and improvements.
ESP Content
When the site began, no journals were making their early content available in digital format. As a result, ESP was obliged to digitize classic literature before it could be made available. For many important papers — such as Mendel's original paper or the first genetic map — ESP had to produce entirely new typeset versions of the works, if they were to be available in a high-quality format.
ESP Help
Early support from the DOE component of the Human Genome Project was critically important for getting the ESP project on a firm foundation. Since that funding ended (nearly 20 years ago), the project has been operated as a purely volunteer effort. Anyone wishing to assist in these efforts should send an email to Robbins.
ESP Plans
With the development of methods for adding typeset side notes to PDF files, the ESP project now plans to add annotated versions of some classical papers to its holdings. We also plan to add new reference and pedagogical material. We have already started providing regularly updated, comprehensive bibliographies to the ESP.ORG site.
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Dinosaur tail, complete with feathers, found preserved in amber.
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Mysterious fast radio burst (FRB) detected in the distant universe.
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Big Data: Buzzword or Big Deal?
Hacking the genome: Identifying anonymized human subjects using publicly available data.
