The ESP Timeline (one of the site's most popular features) has been completely updated to allow the user to select (using the timeline controls above each column) different topics for the left and right sides of the display.
New Left Column
New Left Column
New Right Column
New Right Column
At a Cold Spring Harbor Symposium, Ernst Mayr argues that all hominid specimens so far found should be categorized in the genus Homo: H. transvaalensis, H. erectus, and H. sapiens.
E. Chargaff lays the foundations for nucleic acid structural studies by his analytical work. He demonstrates for DNA that the numbers of adenine and thymine groups are always equal and so are the numbers of guanine and cytosine groups. These findings later suggest to Watson and Crick that DNA consists of two polynucleotide strands joined by hydrogen bonding between A and T and between G and C.
E. M. Lederberg discovers lambda, the first viral episome of E. coli.
(no entry for this year)
Barbara McClintock publishes a paper describing "jumping" genes that can move around within an organism's genome.
Painting by Salvador Dalí: Christ of Saint John of the Cross depicts Jesus Christ on the cross in a darkened sky floating over a body of water complete with a boat and fishermen. Although it is a depiction of the crucifixion, it is devoid of nails, blood, and a crown of thorns, because, according to Dalí, he was convinced by a dream that these features would mar his depiction of Christ. Also in a dream, the importance of depicting Christ in the extreme angle evident in the painting was revealed to him.
A. D. Hershey and M. Chase demonstrate that the DNA of phage enters the host, whereas most of the protein remains behind.
F. Sanger and his colleagues work out the complete amino acid sequence for the protein hormone insulin, and show that it contains two polypeptide chains held together by disulfide bridges.
J. Lederberg and E. M. Lederberg invent the replica plating technique.
N. D. Zinder and J. Lederberg describe transduction in Salmonella.
Painting by Jackson Pollock: Number 11, 1952, also known as Blue Poles, is one of the most famous works by American artist Jackson Pollock. It was purchased amid controversy by the National Gallery of Australia in 1973 and today remains one of the gallery's major paintings. At the time of the painting's creation, Pollock preferred not to assign names to his works, but rather numbers; hence, the original title of the painting was simply "Number 11"' or "No. 11" for the year 1952. In 1954, the new title Blue Poles was first seen at an exhibition at the Sidney Janis Gallery and reportedly originated from Pollock himself. According to art historian Dennis Phillips, the specific rather than ambiguous title "limits our field of comprehension and does the painting a singular disservice. Because we look for the poles and miss much of the rest, the name is simply too distracting."
J. D. Watson and F. H. C. Crick propose a model for DNA comprised of two helically intertwined chains tied together by hydrogen bonds between the purines and pyrimidines.
W. Hayes discovers polarized behavior in bacterial recombinations. He isolates the Hfr H strain of E. coli and shows that certain genes are readily transferred from Hfr to F- bacteria, whereas others are not.
Piltdown Man is determined to be a hoax: the jaw of an ape and a human skull.
Painting by Francis Bacon: Study after Velázquez's Portrait of Pope Innocent X shows a distorted version of the Portrait of Innocent X painted by Spanish artist Diego Velázquez in 1650. The work is one of a series of over 45 variants of the Velázquez painting which Bacon executed throughout the 1950s and early 1960s. The picture was described by Gilles Deleuze as an example of creative re-interpretation of the classical. When asked why he was compelled to revisit the subject so often, Bacon replied that he had nothing against the Popes, that he merely sought "an excuse to use these colours, and you can't give ordinary clothes that purple colour without getting into a sort of false fauve manner".
Elso Barghoorn and Stanley Tyler report the discovery of bacterial cells in Canadian rock formations that are nearly 2 billion years old.
Philip Abelson and his team detect amino acids in fish that are over 300 million years old.
Painting by Jasper Johns: Flag is an encaustic painting created when Johns was 24 (1954-55), two years after he was discharged from the US Army. This painting was the first of many works that Johns has said were inspired by a dream of the U.S. flag in 1954. It is arguably the painting for which Johns is best known. The US flag was in the news repeatedly in 1954. The McCarthy hearings came to a close on 17 June 1954, only three days after Flag Day. On Flag Day, U.S. President Dwight D. Eisenhower signed an amendment to the pledge of allegiance to add the words "under God." The New York Times ran article on facts and myths associated with the flag on the day before Flag Day, and then an article on the "discipline" of the flag on Flag Day itself, saying, with reference to a national air-raid drill "we are all soldiers now". Francis Scott Key, composer of "The Star Spangled Banner", was born in 1779, 175 years before 1954. The Iwo Jima Marine Memorial at Arlington National Cemetery, with its large US flag, was dedicated on 11 November 1954. Johns and his father were both named after Sergeant William Jasper, who saved the fallen flag of the Americans at Fort Moultrie in the American Revolutionary War. The work measures 42.2 inches by 60.6 inches. It is made using encaustic, oil paint, and newsprint collage on three separate canvases, mounted on a plywood board. The painting reflects the three colors of the US flag: red, white and blue; the flag is depicted in the form it took between 1912 and 1959, with 48 white stars on a blue canton representing the then-US states (excluding Alaska and Hawaii), and with thirteen red and white stripes. Newsprint is visible under the stripes. Reading the texts, it is clear that the newsprint was not selected at random: Johns steered clear of headlines, or national or political news, and used inconsequential articles or adverts. The painting has a rough-textured surface, and the 48 stars are not identical. It is dated 1954 on its reverse.
S. Benzer works out the fine structure of the rII region of phage T4 of E. coli, and coins the terms CISTRON,RECON, and MUTON.
Professional pipefitter and amateur paleontologist Francis Tully finds an enigmatic fossil near Morris, Illinois. Dating from about 300 million years ago, the fossil will be formally named Tullimonstrum gregarium and nicknamed the Tully monster. Although it will defy classification for decades, it will nevertheless be named the state fossil of Illinois.
(no entry for this year)
F. Jacob and E. L. Wollman are able experimentally to interrupt the mating process in E. coli and show that a piece of DNA is inserted from the donor bacterium into the recipient.
Fifteen-year-old English schoolgirl Tina Negus finds a specimen of the fossil species that will later be named Charnia masoni, from the geologic period that will later be named the Ediacaran. Unfortunately, Negus can't convince her geography teacher that the fossil she has found is Precambrian and gives up, leaving the fossil to be extracted by local schoolboy Roger Mason the next year.
Keith Runcorn publishes a paper describing polar wandering based on paleomagnetic studies of Europe and North America. He suggests continental drift, but his paper attracts little attention.
Paleontologist M. W. de Laubenfels publishes a paper suggesting that the dinosaurs were driven to extinction by a meteorite impact. His paper will not be taken seriously, but this hypothesis will be presented again in 1980 with more compelling evidence.
Brian Logan and fellow geologists find living stromatolites in Shark Bay, Australia. The find is somewhat surprising as stromatolites have no defenses against mouth-bearing organisms and have probably been relatively rare since the Cambrian Period.
Collage by Richard Hamilton: Just what is it that makes today's homes so different, so appealing? measures 10.25 in (260 mm) × 9.75 in (248 mm). The work is now in the collection of the Kunsthalle Tübingen, Tübingen, Germany. It was the first work of pop art to achieve iconic status. Just what is it that makes today's homes so different, so appealing? was created in 1956 for the catalogue of the exhibition This Is Tomorrow in London, England in which it was reproduced in black and white. In addition, the piece was used in posters for the exhibit. Hamilton and his friends John McHale and John Voelcker had collaborated to create the room that became the best-known part of the exhibition.
Francis Crick proposes the "central dogma" of genetic information transfer: DNA specifies RNA and RNA specifies cell proteins.
V. M. Ingram reports that normal and sickle-cell hemoglobin differ by a single amino acid substitution.
(no entry for this year)
George W. Beadle, Edward L. Tatum, and Joshua Lederberg share a Nobel Prize in Medicine for Beadle and Tatum's discovery that genes act by regulating definite chemical events, and for Lederberg's discoveries concerning genetic recombination and the organization of the genetic material of bacteria.
F. H. C. Crick suggests that during protein formation the amino acid is carried to the template by an adaptor molecule containing nucleotides and that the adaptor is the part that actually fits on the RNA template. Crick thus predicts the discovery of transfer RNA.
F. Jacob and E. L. Wollman demonstrate that the single linkage group of E. coli is circular and suggest that the different linkage groups found in different Hfr strains result from the insertion at different points of a factor in the circular linkage group that determines the rupture of the circle.
M. Meselson and F. W. Stahl use the density gradient equilibrium centrifugation technique to demonstrate the semiconservative distribution of density label during DNA replication in E. coli.
(no entry for this year)
J. Lejeune, M. Gautier, and R. Turpin show that Down syndrome is a chromosomal aberration involving trisomy of a small telocentric chromosome.
R. L. Sinsheimer demonstrates that bacteriophage phiX174 of E. coli contains a single-stranded DNA molecule.
Mary Leakey finds hominid skull belonging to Paranthropus boisei.
(no entry for this year)
In the early 1990's, Robert Robbins was a faculty member at Johns Hopkins, where he directed the informatics core of GDB — the human gene-mapping database of the international human genome project. To share papers with colleagues around the world, he set up a small paper-sharing section on his personal web page. This small project evolved into The Electronic Scholarly Publishing Project.
In 1995, Robbins became the VP/IT of the Fred Hutchinson Cancer Research Center in Seattle, WA. Soon after arriving in Seattle, Robbins secured funding, through the ELSI component of the US Human Genome Project, to create the original ESP.ORG web site, with the formal goal of providing free, world-wide access to the literature of classical genetics.
Although the methods of molecular biology can seem almost magical to the uninitiated, the original techniques of classical genetics are readily appreciated by one and all: cross individuals that differ in some inherited trait, collect all of the progeny, score their attributes, and propose mechanisms to explain the patterns of inheritance observed.
In reading the early works of classical genetics, one is drawn, almost inexorably, into ever more complex models, until molecular explanations begin to seem both necessary and natural. At that point, the tools for understanding genome research are at hand. Assisting readers reach this point was the original goal of The Electronic Scholarly Publishing Project.
Usage of the site grew rapidly and has remained high. Faculty began to use the site for their assigned readings. Other on-line publishers, ranging from The New York Times to Nature referenced ESP materials in their own publications. Nobel laureates (e.g., Joshua Lederberg) regularly used the site and even wrote to suggest changes and improvements.
When the site began, no journals were making their early content available in digital format. As a result, ESP was obliged to digitize classic literature before it could be made available. For many important papers — such as Mendel's original paper or the first genetic map — ESP had to produce entirely new typeset versions of the works, if they were to be available in a high-quality format.
Early support from the DOE component of the Human Genome Project was critically important for getting the ESP project on a firm foundation. Since that funding ended (nearly 20 years ago), the project has been operated as a purely volunteer effort. Anyone wishing to assist in these efforts should send an email to Robbins.
With the development of methods for adding typeset side notes to PDF files, the ESP project now plans to add annotated versions of some classical papers to its holdings. We also plan to add new reference and pedagogical material. We have already started providing regularly updated, comprehensive bibliographies to the ESP.ORG site.
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